CRLF3 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	CRLF3
Entrez Gene ID	51379
Full Name	cytokine receptor like factor 3
Synonyms	CREME-9,CREME9,CRLM9,CYTOR4,FRWS,p48.2
General protein information	Preferred Names cytokine receptor like factor 3 Names cytokine receptor-like factor 3 cytokine receptor-like molecule 9 cytokine receptor-related protein 4 type I cytokine receptor-like factor p48
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 17 Map Location: 17q11.2
Summary	This gene encodes a cytokine receptor-like factor that may negatively regulate cell cycle progression at the G0/G1 phase. Studies of the related rat protein suggest that it may regulate neuronal morphology and synaptic vesicle biogenesis. This gene is one of several genes located in the neurofibromatosis type I tumor suppressor region on the q arm of chromosome 17, a region that is subject to microdeletions, duplications, chromosomal breaks and rearrangements. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 2 and 5. [provided by RefSeq, Aug 2012].
Disorder MIM:	614853

mRNA and Protein(s)

mRNA	Protein	Name
NM_015986.3	NP_057070.3	cytokine receptor-like factor 3
XM_011524879.1	XP_011523181.1	cytokine receptor-like factor 3 isoform X1
NM_015986.4	NP_057070.3	cytokine receptor-like factor 3

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Crlf3	NP_061246.1
Xenopus tropicalis (tropical clawed frog)	crlf3	XP_002943331.1
Gallus gallus (chicken)	CRLF3	NP_001073187.2
Pan troglodytes (chimpanzee)	CRLF3	XP_523594.2
Bos taurus (cattle)	CRLF3	NP_001179579.1
Rattus norvegicus (Norway rat)	Crlf3	NP_001162083.1
Homo sapiens (human)	CRLF3	NP_057070.3
	CRLF3	XP_001112406.1
Canis lupus familiaris (dog)	CRLF3	XP_548277.3
Danio rerio (zebrafish)	crlf3	NP_001017817.2

Gene Ontology
Bibliography

Related articles in PubMed

Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.
Yang X, Coulombe-Huntington J, Kang S, Sheynkman GM, Hao T, Richardson A, Sun S, Yang F, Shen YA, Murray RR, Spirohn K, Begg BE, Duran-Frigola M, MacWilliams A, Pevzner SJ, Zhong Q, Trigg SA, Tam S, Ghamsari L, Sahni N, Yi S, Rodriguez MD, Balcha D, Tan G, Costanzo M, Andrews B, Boone C, Zhou XJ, Salehi-Ashtiani K, Charloteaux B, Chen AA, Calderwood MA, Aloy P, Roth FP, Hill DE, Iakoucheva LM, Xia Y, Vidal M
Cell164(4)805-17(2016 Feb)

Uncovering genes required for neuronal morphology by morphology-based gene trap screening with a revertible retrovirus vector.
Hashimoto Y, Muramatsu K, Kunii M, Yoshimura S, Yamada M, Sato T, Ishida Y, Harada R, Harada A
FASEB journal : official publication of the Federation of American Societies for Experimental Biology26(11)4662-74(2012 Nov)

Cloning and characterization of a novel intracellular protein p48.2 that negatively regulates cell cycle progression.
Yang F, Xu YP, Li J, Duan SS, Fu YJ, Zhang Y, Zhao Y, Qiao WT, Chen QM, Geng YQ, Che CY, Cao YL, Wang Y, Zhang L, Long L, He J, Cui QC, Chen SC, Wang SH, Liu L
The international journal of biochemistry & cell biology41(11)2240-50(2009 Nov)

RNF135 mutations are not present in patients with Sotos syndrome-like features.
Visser R, Koelma N, Vijfhuizen L, van der Wielen MJ, Kant SG, Breuning MH, Wit JM, Losekoot M
American journal of medical genetics. Part A149A(4)806-8(2009 Feb)

Mutations in RNF135, a gene within the NF1 microdeletion region, cause phenotypic abnormalities including overgrowth.
Douglas J, Cilliers D, Coleman K, Tatton-Brown K, Barker K, Bernhard B, Burn J, Huson S, Josifova D, Lacombe D, Malik M, Mansour S, Reid E, Cormier-Daire V, Cole T, , Rahman N
Nature genetics39(8)963-5(2007 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Meta-analysis of gene-disease association. (HuGE Navigator)
Title: Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot".

Observational study of gene-disease association. (HuGE Navigator)
Title: The role of height-associated loci identified in genome wide association studies in the determination of pediatric stature.

p48.2 may represent a novel type of intracellular protein functioning as a negative regulator at the G0/G1 phase.
Title: Cloning and characterization of a novel intracellular protein p48.2 that negatively regulates cell cycle progression.

Observational study of gene-disease association. (HuGE Navigator)
Title: RNF135 mutations are not present in patients with Sotos syndrome-like features.

Suggests that the homologous rat protein is involved in neuronal morphology regulation.
Title: Serum-free culture of Japanese quail kidney cells. Regulation of vitamin D metabolism.

The following CRLF3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CRLF3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu19258	NM_015986.4 Latest version!	Homo sapiens cytokine receptor like factor 3 (CRLF3), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
OHu67898	XM_011524879.1 Latest version!	Homo sapiens cytokine receptor like factor 3 (CRLF3), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$139.30 $199.00
View Old Accession Versions >>
OHu19258	NM_015986.3	Homo sapiens cytokine receptor like factor 3 (CRLF3), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CRLF3 ( NM_015986.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_057070.3 Homo sapiens cytokine receptor like factor 3 (CRLF3), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu19258
Clone ID Related Accession (Same CDS sequence)	NM_015986.3 , NM_015986.4
Accession Version	NM_015986.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1329bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-11-26
Organism	Homo sapiens(human)
Product	cytokine receptor-like factor 3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BU902521.1, BC023567.2 and AA993312.1. This sequence is a reference standard in the RefSeqGene project. On Aug 21, 2007 this sequence version replaced NM_015986.2. Transcript Variant: This variant (1) represents the longer transcript and encodes the supported protein. ##Evidence-Data-START## Transcript exon combination :: AF046059.1, SRR1660809.33060.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAGGGGGG CGATGGAGCT GGAGCCTGAG CTGCTGTTGC AGGAGGCCCG CGAGAACGTG 
GAGGCAGCGC AGAGCTACCG GCGGGAGCTG GGTCACCGGC TTGAGGGGCT GCGTGAGGCG 
CGGAGGCAGA TCAAAGAAAG TGCATCACAG ACAAGGGATG TTCTCAAACA GCATTTTAAT 
GATTTAAAGG GAACCCTTGG AAAGCTCCTG GATGAGCGAT TGGTGACCCT TTTGCAAGAG 
GTGGACACCA TTGAACAGGA GACCATTAAA CCACTAGATG ACTGCCAGAA GCTCATAGAA 
CACGGAGTCA ACACTGCAGA GGACTTAGTC CGAGAAGGTG AAATCGCCAT GCTTGGTGGT 
GTGGGAGAAG AGAATGAGAA ACTGTGGAGC TTTACCAAAA AGGCCTCGCA CATTCAGTTG 
GACAGCTTAC CAGAAGTACC TTTACTGGTT GATGTGCCTT GTTTATCTGC TCAGTTGGAT 
GACTCAATTC TTAACATAGT GAAAGACCAC ATTTTTAAGC ATGGAACAGT AGCATCTCGC 
CCACCAGTAC AGATAGAAGA ACTAATAGAG AAACCTGGAG GCATCATTGT ACGATGGTGT 
AAGGTGGATG ATGACTTTAC AGCCCAAGAT TACAGGCTCC AGTTTCGTAA ATGTACTTCA 
AATCATTTTG AGGATGTATA TGTAGGTTCT GAAACTGAAT TCATAGTATT GCACATAGAC 
CCCAACGTTG ATTACCAGTT CAGAGTCTGC GCCCGAGGAG ATGGCCGACA GGAGTGGAGT 
CCTTGGAGTG TCCCCCAGAT AGGTCATTCC ACATTGGTGC CTCATGAGTG GACAGCTGGT 
TTTGAGGGGT ACAGTCTGAG CAGTCGAAGA AATATAGCAC TTCGGAACGA TTCTGAATCA 
TCGGGTGTTC TCTACTCCAG AGCTCCGACT TATTTCTGTG GGCAGACATT AACATTCAGA 
GTTGAAACTG TGGGACAGCC AGACAGAAGA GATAGCATAG GAGTGTGTGC AGAAAAACAG 
GATGGATATG ACTCTCTGCA GCGGGATCAA GCTGTGTGCA TTAGTACAAA TGGTGCAGTT 
TTTGTCAATG GAAAAGAAAT GACAAATCAG TTACCCGCAG TTACTTCTGG GTCCACTGTC 
ACGTTTGACA TTGAAGCCGT GACTCTAGGA ACCACCAGTA ATAATGAAGG TGGACACTTC 
AAGCTTCGAG TAACTATAAG TTCAAATAAT AGAGAAGTGG TTTTTGACTG GTTACTTGAT 
CAGTCTTGTG GTTCTCTTTA CTTTGGATGC TCATTTTTCT ATCCTGGATG GAAAGTGTTA 
GTGTTTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_057070.3
CDS	110..1438
Translation	MRGAMELEPELLLQEARENVEAAQSYRRELGHRLEGLREARRQIKESASQTRDVLKQHFNDLKGTLGKLLDERLVTLLQEVDTIEQETIKPLDDCQKLIEHGVNTAEDLVREGEIAMLGGVGEENEKLWSFTKKASHIQLDSLPEVPLLVDVPCLSAQLDDSILNIVKDHIFKHGTVASRPPVQIEELIEKPGGIIVRWCKVDDDFTAQDYRLQFRKCTSNHFEDVYVGSETEFIVLHIDPNVDYQFRVCARGDGRQEWSPWSVPQIGHSTLVPHEWTAGFEGYSLSSRRNIALRNDSESSGVLYSRAPTYFCGQTLTFRVETVGQPDRRDSIGVCAEKQDGYDSLQRDQAVCISTNGAVFVNGKEMTNQLPAVTSGSTVTFDIEAVTLGTTSNNEGGHFKLRVTISSNNREVVFDWLLDQSCGSLYFGCSFFYPGWKVLVF

Target ORF information:

RefSeq Version	NM_015986.3
Organism	Homo sapiens(human)
Definition	Homo sapiens cytokine receptor like factor 3 (CRLF3), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_015986.3

ORF Insert Sequence:

ATGAGGGGGG CGATGGAGCT GGAGCCTGAG CTGCTGTTGC AGGAGGCCCG CGAGAACGTG 
GAGGCAGCGC AGAGCTACCG GCGGGAGCTG GGTCACCGGC TTGAGGGGCT GCGTGAGGCG 
CGGAGGCAGA TCAAAGAAAG TGCATCACAG ACAAGGGATG TTCTCAAACA GCATTTTAAT 
GATTTAAAGG GAACCCTTGG AAAGCTCCTG GATGAGCGAT TGGTGACCCT TTTGCAAGAG 
GTGGACACCA TTGAACAGGA GACCATTAAA CCACTAGATG ACTGCCAGAA GCTCATAGAA 
CACGGAGTCA ACACTGCAGA GGACTTAGTC CGAGAAGGTG AAATCGCCAT GCTTGGTGGT 
GTGGGAGAAG AGAATGAGAA ACTGTGGAGC TTTACCAAAA AGGCCTCGCA CATTCAGTTG 
GACAGCTTAC CAGAAGTACC TTTACTGGTT GATGTGCCTT GTTTATCTGC TCAGTTGGAT 
GACTCAATTC TTAACATAGT GAAAGACCAC ATTTTTAAGC ATGGAACAGT AGCATCTCGC 
CCACCAGTAC AGATAGAAGA ACTAATAGAG AAACCTGGAG GCATCATTGT ACGATGGTGT 
AAGGTGGATG ATGACTTTAC AGCCCAAGAT TACAGGCTCC AGTTTCGTAA ATGTACTTCA 
AATCATTTTG AGGATGTATA TGTAGGTTCT GAAACTGAAT TCATAGTATT GCACATAGAC 
CCCAACGTTG ATTACCAGTT CAGAGTCTGC GCCCGAGGAG ATGGCCGACA GGAGTGGAGT 
CCTTGGAGTG TCCCCCAGAT AGGTCATTCC ACATTGGTGC CTCATGAGTG GACAGCTGGT 
TTTGAGGGGT ACAGTCTGAG CAGTCGAAGA AATATAGCAC TTCGGAACGA TTCTGAATCA 
TCGGGTGTTC TCTACTCCAG AGCTCCGACT TATTTCTGTG GGCAGACATT AACATTCAGA 
GTTGAAACTG TGGGACAGCC AGACAGAAGA GATAGCATAG GAGTGTGTGC AGAAAAACAG 
GATGGATATG ACTCTCTGCA GCGGGATCAA GCTGTGTGCA TTAGTACAAA TGGTGCAGTT 
TTTGTCAATG GAAAAGAAAT GACAAATCAG TTACCCGCAG TTACTTCTGG GTCCACTGTC 
ACGTTTGACA TTGAAGCCGT GACTCTAGGA ACCACCAGTA ATAATGAAGG TGGACACTTC 
AAGCTTCGAG TAACTATAAG TTCAAATAAT AGAGAAGTGG TTTTTGACTG GTTACTTGAT 
CAGTCTTGTG GTTCTCTTTA CTTTGGATGC TCATTTTTCT ATCCTGGATG GAAAGTGTTA 
GTGTTTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CRLF3 ( NM_015986.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_057070.3 Homo sapiens cytokine receptor like factor 3 (CRLF3), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu19258
Clone ID Related Accession (Same CDS sequence)	NM_015986.3 , NM_015986.4
Accession Version	NM_015986.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1329bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-25
Organism	Homo sapiens(human)
Product	cytokine receptor-like factor 3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BU902521.1, BC023567.2 and AA993312.1. This sequence is a reference standard in the RefSeqGene project. On Nov 22, 2018 this sequence version replaced NM_015986.3. Transcript Variant: This variant (1) represents the longer transcript and encodes the supported protein. ##Evidence-Data-START## Transcript exon combination :: AF046059.1, BC023567.2 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000324238.7/ ENSP00000318804.6 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGAGGGGGG CGATGGAGCT GGAGCCTGAG CTGCTGTTGC AGGAGGCCCG CGAGAACGTG 
GAGGCAGCGC AGAGCTACCG GCGGGAGCTG GGTCACCGGC TTGAGGGGCT GCGTGAGGCG 
CGGAGGCAGA TCAAAGAAAG TGCATCACAG ACAAGGGATG TTCTCAAACA GCATTTTAAT 
GATTTAAAGG GAACCCTTGG AAAGCTCCTG GATGAGCGAT TGGTGACCCT TTTGCAAGAG 
GTGGACACCA TTGAACAGGA GACCATTAAA CCACTAGATG ACTGCCAGAA GCTCATAGAA 
CACGGAGTCA ACACTGCAGA GGACTTAGTC CGAGAAGGTG AAATCGCCAT GCTTGGTGGT 
GTGGGAGAAG AGAATGAGAA ACTGTGGAGC TTTACCAAAA AGGCCTCGCA CATTCAGTTG 
GACAGCTTAC CAGAAGTACC TTTACTGGTT GATGTGCCTT GTTTATCTGC TCAGTTGGAT 
GACTCAATTC TTAACATAGT GAAAGACCAC ATTTTTAAGC ATGGAACAGT AGCATCTCGC 
CCACCAGTAC AGATAGAAGA ACTAATAGAG AAACCTGGAG GCATCATTGT ACGATGGTGT 
AAGGTGGATG ATGACTTTAC AGCCCAAGAT TACAGGCTCC AGTTTCGTAA ATGTACTTCA 
AATCATTTTG AGGATGTATA TGTAGGTTCT GAAACTGAAT TCATAGTATT GCACATAGAC 
CCCAACGTTG ATTACCAGTT CAGAGTCTGC GCCCGAGGAG ATGGCCGACA GGAGTGGAGT 
CCTTGGAGTG TCCCCCAGAT AGGTCATTCC ACATTGGTGC CTCATGAGTG GACAGCTGGT 
TTTGAGGGGT ACAGTCTGAG CAGTCGAAGA AATATAGCAC TTCGGAACGA TTCTGAATCA 
TCGGGTGTTC TCTACTCCAG AGCTCCGACT TATTTCTGTG GGCAGACATT AACATTCAGA 
GTTGAAACTG TGGGACAGCC AGACAGAAGA GATAGCATAG GAGTGTGTGC AGAAAAACAG 
GATGGATATG ACTCTCTGCA GCGGGATCAA GCTGTGTGCA TTAGTACAAA TGGTGCAGTT 
TTTGTCAATG GAAAAGAAAT GACAAATCAG TTACCCGCAG TTACTTCTGG GTCCACTGTC 
ACGTTTGACA TTGAAGCCGT GACTCTAGGA ACCACCAGTA ATAATGAAGG TGGACACTTC 
AAGCTTCGAG TAACTATAAG TTCAAATAAT AGAGAAGTGG TTTTTGACTG GTTACTTGAT 
CAGTCTTGTG GTTCTCTTTA CTTTGGATGC TCATTTTTCT ATCCTGGATG GAAAGTGTTA 
GTGTTTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_057070.3
CDS	42..1370
Translation	MRGAMELEPELLLQEARENVEAAQSYRRELGHRLEGLREARRQIKESASQTRDVLKQHFNDLKGTLGKLLDERLVTLLQEVDTIEQETIKPLDDCQKLIEHGVNTAEDLVREGEIAMLGGVGEENEKLWSFTKKASHIQLDSLPEVPLLVDVPCLSAQLDDSILNIVKDHIFKHGTVASRPPVQIEELIEKPGGIIVRWCKVDDDFTAQDYRLQFRKCTSNHFEDVYVGSETEFIVLHIDPNVDYQFRVCARGDGRQEWSPWSVPQIGHSTLVPHEWTAGFEGYSLSSRRNIALRNDSESSGVLYSRAPTYFCGQTLTFRVETVGQPDRRDSIGVCAEKQDGYDSLQRDQAVCISTNGAVFVNGKEMTNQLPAVTSGSTVTFDIEAVTLGTTSNNEGGHFKLRVTISSNNREVVFDWLLDQSCGSLYFGCSFFYPGWKVLVF

Target ORF information:

RefSeq Version	NM_015986.4
Organism	Homo sapiens(human)
Definition	Homo sapiens cytokine receptor like factor 3 (CRLF3), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_015986.4

ORF Insert Sequence:

ATGAGGGGGG CGATGGAGCT GGAGCCTGAG CTGCTGTTGC AGGAGGCCCG CGAGAACGTG 
GAGGCAGCGC AGAGCTACCG GCGGGAGCTG GGTCACCGGC TTGAGGGGCT GCGTGAGGCG 
CGGAGGCAGA TCAAAGAAAG TGCATCACAG ACAAGGGATG TTCTCAAACA GCATTTTAAT 
GATTTAAAGG GAACCCTTGG AAAGCTCCTG GATGAGCGAT TGGTGACCCT TTTGCAAGAG 
GTGGACACCA TTGAACAGGA GACCATTAAA CCACTAGATG ACTGCCAGAA GCTCATAGAA 
CACGGAGTCA ACACTGCAGA GGACTTAGTC CGAGAAGGTG AAATCGCCAT GCTTGGTGGT 
GTGGGAGAAG AGAATGAGAA ACTGTGGAGC TTTACCAAAA AGGCCTCGCA CATTCAGTTG 
GACAGCTTAC CAGAAGTACC TTTACTGGTT GATGTGCCTT GTTTATCTGC TCAGTTGGAT 
GACTCAATTC TTAACATAGT GAAAGACCAC ATTTTTAAGC ATGGAACAGT AGCATCTCGC 
CCACCAGTAC AGATAGAAGA ACTAATAGAG AAACCTGGAG GCATCATTGT ACGATGGTGT 
AAGGTGGATG ATGACTTTAC AGCCCAAGAT TACAGGCTCC AGTTTCGTAA ATGTACTTCA 
AATCATTTTG AGGATGTATA TGTAGGTTCT GAAACTGAAT TCATAGTATT GCACATAGAC 
CCCAACGTTG ATTACCAGTT CAGAGTCTGC GCCCGAGGAG ATGGCCGACA GGAGTGGAGT 
CCTTGGAGTG TCCCCCAGAT AGGTCATTCC ACATTGGTGC CTCATGAGTG GACAGCTGGT 
TTTGAGGGGT ACAGTCTGAG CAGTCGAAGA AATATAGCAC TTCGGAACGA TTCTGAATCA 
TCGGGTGTTC TCTACTCCAG AGCTCCGACT TATTTCTGTG GGCAGACATT AACATTCAGA 
GTTGAAACTG TGGGACAGCC AGACAGAAGA GATAGCATAG GAGTGTGTGC AGAAAAACAG 
GATGGATATG ACTCTCTGCA GCGGGATCAA GCTGTGTGCA TTAGTACAAA TGGTGCAGTT 
TTTGTCAATG GAAAAGAAAT GACAAATCAG TTACCCGCAG TTACTTCTGG GTCCACTGTC 
ACGTTTGACA TTGAAGCCGT GACTCTAGGA ACCACCAGTA ATAATGAAGG TGGACACTTC 
AAGCTTCGAG TAACTATAAG TTCAAATAAT AGAGAAGTGG TTTTTGACTG GTTACTTGAT 
CAGTCTTGTG GTTCTCTTTA CTTTGGATGC TCATTTTTCT ATCCTGGATG GAAAGTGTTA 
GTGTTTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CRLF3 ( XM_011524879.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_011523181.1 Homo sapiens cytokine receptor like factor 3 (CRLF3), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu67898
Clone ID Related Accession (Same CDS sequence)	XM_011524879.1
Accession Version	XM_011524879.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 981bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	cytokine receptor-like factor 3 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000017.11) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCTTGGTG GTGTGGGAGA AGAGAATGAG AAACTGTGGA GCTTTACCAA AAAGGCCTCG 
CACATTCAGT TGGACAGCTT ACCAGAAGTA CCTTTACTGG TTGATGTGCC TTGTTTATCT 
GCTCAGTTGG ATGACTCAAT TCTTAACATA GTGAAAGACC ACATTTTTAA GCATGGAACA 
GTAGCATCTC GCCCACCAGT ACAGATAGAA GAACTAATAG AGAAACCTGG AGGCATCATT 
GTACGATGGT GTAAGGTGGA TGATGACTTT ACAGCCCAAG ATTACAGGCT CCAGTTTCGT 
AAATGTACTT CAAATCATTT TGAGGATGTA TATGTAGGTT CTGAAACTGA ATTCATAGTA 
TTGCACATAG ACCCCAACGT TGATTACCAG TTCAGAGTCT GCGCCCGAGG AGATGGCCGA 
CAGGAGTGGA GTCCTTGGAG TGTCCCCCAG ATAGGTCATT CCACATTGGT GCCTCATGAG 
TGGACAGCTG GTTTTGAGGG GTACAGTCTG AGCAGTCGAA GAAATATAGC ACTTCGGAAC 
GATTCTGAAT CATCGGGTGT TCTCTACTCC AGAGCTCCGA CTTATTTCTG TGGGCAGACA 
TTAACATTCA GAGTTGAAAC TGTGGGACAG CCAGACAGAA GAGATAGCAT AGGAGTGTGT 
GCAGAAAAAC AGGATGGATA TGACTCTCTG CAGCGGGATC AAGCTGTGTG CATTAGTACA 
AATGGTGCAG TTTTTGTCAA TGGAAAAGAA ATGACAAATC AGTTACCCGC AGTTACTTCT 
GGGTCCACTG TCACGTTTGA CATTGAAGCC GTGACTCTAG GAACCACCAG TAATAATGAA 
GGTGGACACT TCAAGCTTCG AGTAACTATA AGTTCAAATA ATAGAGAAGT GGTTTTTGAC 
TGGTTACTTG ATCAGTCTTG TGGTTCTCTT TACTTTGGAT GCTCATTTTT CTATCCTGGA 
TGGAAAGTGT TAGTGTTTTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011523181.1
CDS	632..1612
Translation	MLGGVGEENEKLWSFTKKASHIQLDSLPEVPLLVDVPCLSAQLDDSILNIVKDHIFKHGTVASRPPVQIEELIEKPGGIIVRWCKVDDDFTAQDYRLQFRKCTSNHFEDVYVGSETEFIVLHIDPNVDYQFRVCARGDGRQEWSPWSVPQIGHSTLVPHEWTAGFEGYSLSSRRNIALRNDSESSGVLYSRAPTYFCGQTLTFRVETVGQPDRRDSIGVCAEKQDGYDSLQRDQAVCISTNGAVFVNGKEMTNQLPAVTSGSTVTFDIEAVTLGTTSNNEGGHFKLRVTISSNNREVVFDWLLDQSCGSLYFGCSFFYPGWKVLVF

Target ORF information:

RefSeq Version	XM_011524879.1
Organism	Homo sapiens(human)
Definition	Homo sapiens cytokine receptor like factor 3 (CRLF3), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011524879.1

ORF Insert Sequence:

ATGCTTGGTG GTGTGGGAGA AGAGAATGAG AAACTGTGGA GCTTTACCAA AAAGGCCTCG 
CACATTCAGT TGGACAGCTT ACCAGAAGTA CCTTTACTGG TTGATGTGCC TTGTTTATCT 
GCTCAGTTGG ATGACTCAAT TCTTAACATA GTGAAAGACC ACATTTTTAA GCATGGAACA 
GTAGCATCTC GCCCACCAGT ACAGATAGAA GAACTAATAG AGAAACCTGG AGGCATCATT 
GTACGATGGT GTAAGGTGGA TGATGACTTT ACAGCCCAAG ATTACAGGCT CCAGTTTCGT 
AAATGTACTT CAAATCATTT TGAGGATGTA TATGTAGGTT CTGAAACTGA ATTCATAGTA 
TTGCACATAG ACCCCAACGT TGATTACCAG TTCAGAGTCT GCGCCCGAGG AGATGGCCGA 
CAGGAGTGGA GTCCTTGGAG TGTCCCCCAG ATAGGTCATT CCACATTGGT GCCTCATGAG 
TGGACAGCTG GTTTTGAGGG GTACAGTCTG AGCAGTCGAA GAAATATAGC ACTTCGGAAC 
GATTCTGAAT CATCGGGTGT TCTCTACTCC AGAGCTCCGA CTTATTTCTG TGGGCAGACA 
TTAACATTCA GAGTTGAAAC TGTGGGACAG CCAGACAGAA GAGATAGCAT AGGAGTGTGT 
GCAGAAAAAC AGGATGGATA TGACTCTCTG CAGCGGGATC AAGCTGTGTG CATTAGTACA 
AATGGTGCAG TTTTTGTCAA TGGAAAAGAA ATGACAAATC AGTTACCCGC AGTTACTTCT 
GGGTCCACTG TCACGTTTGA CATTGAAGCC GTGACTCTAG GAACCACCAG TAATAATGAA 
GGTGGACACT TCAAGCTTCG AGTAACTATA AGTTCAAATA ATAGAGAAGT GGTTTTTGAC 
TGGTTACTTG ATCAGTCTTG TGGTTCTCTT TACTTTGGAT GCTCATTTTT CTATCCTGGA 
TGGAAAGTGT TAGTGTTTTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.
Cell164(4)805-17(2016 Feb)
Yang X,Coulombe-Huntington J,Kang S,Sheynkman GM,Hao T,Richardson A,Sun S,Yang F,Shen YA,Murray RR,Spirohn K,Begg BE,Duran-Frigola M,MacWilliams A,Pevzner SJ,Zhong Q,Trigg SA,Tam S,Ghamsari L,Sahni N,Yi S,Rodriguez MD,Balcha D,Tan G,Costanzo M,Andrews B,Boone C,Zhou XJ,Salehi-Ashtiani K,Charloteaux B,Chen AA,Calderwood MA,Aloy P,Roth FP,Hill DE,Iakoucheva LM,Xia Y,Vidal M

Uncovering genes required for neuronal morphology by morphology-based gene trap screening with a revertible retrovirus vector.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology26(11)4662-74(2012 Nov)
Hashimoto Y,Muramatsu K,Kunii M,Yoshimura S,Yamada M,Sato T,Ishida Y,Harada R,Harada A

Cloning and characterization of a novel intracellular protein p48.2 that negatively regulates cell cycle progression.
The international journal of biochemistry & cell biology41(11)2240-50(2009 Nov)
Yang F,Xu YP,Li J,Duan SS,Fu YJ,Zhang Y,Zhao Y,Qiao WT,Chen QM,Geng YQ,Che CY,Cao YL,Wang Y,Zhang L,Long L,He J,Cui QC,Chen SC,Wang SH,Liu L

RNF135 mutations are not present in patients with Sotos syndrome-like features.
American journal of medical genetics. Part A149A(4)806-8(2009 Feb)
Visser R,Koelma N,Vijfhuizen L,van der Wielen MJ,Kant SG,Breuning MH,Wit JM,Losekoot M

Mutations in RNF135, a gene within the NF1 microdeletion region, cause phenotypic abnormalities including overgrowth.
Nature genetics39(8)963-5(2007 Aug)
Douglas J,Cilliers D,Coleman K,Tatton-Brown K,Barker K,Bernhard B,Burn J,Huson S,Josifova D,Lacombe D,Malik M,Mansour S,Reid E,Cormier-Daire V,Cole T,,Rahman N

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CRLF3 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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