MRPS17 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	MRPS17
Entrez Gene ID	51373
Full Name	mitochondrial ribosomal protein S17
Synonyms	HSPC011,MRP-S17,RPMS17,S17mt
General protein information	Preferred Names mitochondrial ribosomal protein S17 Names 28S ribosomal protein S17, mitochondrial mitochondrial small ribosomal subunit protein uS17m
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 7 Map Location: 7p11.2
Summary	Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S17P family. The encoded protein is moderately conserved between human mitochondrial and prokaryotic ribosomal proteins. Pseudogenes corresponding to this gene are found on chromosomes 1p, 3p, 6q, 14p, 18q, and Xq. [provided by RefSeq, Jul 2008].
Disorder MIM:	611980

mRNA and Protein(s)

mRNA	Protein	Name
NM_015969.2	NP_057053.1	28S ribosomal protein S17, mitochondrial
NM_015969.3	NP_057053.1	28S ribosomal protein S17, mitochondrial

Pathways from BioSystems

Homologies

Danio rerio (zebrafish)	zgc:110031	NP_001018395.1
Pan troglodytes (chimpanzee)	MRPS17	NP_001238901.1
Bos taurus (cattle)	MRPS17	NP_001019671.1
Rattus norvegicus (Norway rat)	Mrps17	NP_001099393.1
Gallus gallus (chicken)	MRPS17	NP_001185576.1
Homo sapiens (human)	MRPS17	NP_057053.1
Mus musculus (house mouse)	Mrps17	NP_079726.1
Xenopus tropicalis (tropical clawed frog)	mrps17	NP_001017055.1
	LOC712034	XP_001100912.2
Canis lupus familiaris (dog)	MRPS17	XP_005620966.1

Gene Ontology
Bibliography

Related articles in PubMed

Ribosome. The structure of the human mitochondrial ribosome.
Amunts A, Brown A, Toots J, Scheres SHW, Ramakrishnan V
Science (New York, N.Y.)348(6230)95-98(2015 Apr)

Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
Hendrickson SL, Lautenberger JA, Chinn LW, Malasky M, Sezgin E, Kingsley LA, Goedert JJ, Kirk GD, Gomperts ED, Buchbinder SP, Troyer JL, O'Brien SJ
PloS one5(9)e12862(2010 Sep)

Identification and characterization of over 100 mitochondrial ribosomal protein pseudogenes in the human genome.
Zhang Z, Gerstein M
Genomics81(5)468-80(2003 May)

The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders.
Kenmochi N, Suzuki T, Uechi T, Magoori M, Kuniba M, Higa S, Watanabe K, Tanaka T
Genomics77(1-2)65-70(2001 Sep)

Proteomic analysis of the mammalian mitochondrial ribosome. Identification of protein components in the 28 S small subunit.
Suzuki T, Terasaki M, Takemoto-Hori C, Hanada T, Ueda T, Wada A, Watanabe K
The Journal of biological chemistry276(35)33181-95(2001 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Observational study of gene-disease association. (HuGE Navigator)
Title: Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.

The following MRPS17 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MRPS17 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu29666	NM_015969.3 Latest version!	Homo sapiens mitochondrial ribosomal protein S17 (MRPS17), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu29666	NM_015969.2	Homo sapiens mitochondrial ribosomal protein S17 (MRPS17), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

MRPS17 ( NM_015969.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_057053.1 Homo sapiens mitochondrial ribosomal protein S17 (MRPS17), mRNA.

Price & Availability↑

CloneID	OHu29666
Clone ID Related Accession (Same CDS sequence)	NM_015969.2 , NM_015969.3
Accession Version	NM_015969.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 393bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-30
Organism	Homo sapiens(human)
Product	28S ribosomal protein S17, mitochondrial
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF077035.1. On Oct 31, 2001 this sequence version replaced NM_015969.1. ##Evidence-Data-START## Transcript exon combination :: AF077035.1, SRR1163658.488486.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGTCCGTAG TTCGCTCATC CGTCCATGCC AGATGGATTG TGGGGAAGGT GATTGGGACA 
AAAATGCAAA AGACTGCTAA AGTGAGAGTG ACCAGGCTTG TTCTGGATCC CTATTTATTA 
AAGTATTTTA ATAAGCGGAA AACCTACTTT GCTCACGATG CCCTTCAGCA GTGCACAGTT 
GGGGATATTG TGCTTCTCAG AGCTTTACCT GTTCCACGAG CAAAGCATGT GAAACATGAA 
CTGGCTGAGA TCGTTTTCAA AGTTGGAAAA GTCATAGATC CAGTGACAGG AAAGCCCTGT 
GCTGGAACTA CCTACCTGGA GAGTCCGTTG AGTTCGGAAA CCACCCAGCT AAGCAAAAAT 
CTGGAAGAAC TCAATATCTC TTCAGCACAG TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_057053.1
CDS	31..423
Translation	MSVVRSSVHARWIVGKVIGTKMQKTAKVRVTRLVLDPYLLKYFNKRKTYFAHDALQQCTVGDIVLLRALPVPRAKHVKHELAEIVFKVGKVIDPVTGKPCAGTTYLESPLSSETTQLSKNLEELNISSAQ

Target ORF information:

RefSeq Version	NM_015969.2
Organism	Homo sapiens(human)
Definition	Homo sapiens mitochondrial ribosomal protein S17 (MRPS17), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_015969.2

ORF Insert Sequence:

ATGTCCGTAG TTCGCTCATC CGTCCATGCC AGATGGATTG TGGGGAAGGT GATTGGGACA 
AAAATGCAAA AGACTGCTAA AGTGAGAGTG ACCAGGCTTG TTCTGGATCC CTATTTATTA 
AAGTATTTTA ATAAGCGGAA AACCTACTTT GCTCACGATG CCCTTCAGCA GTGCACAGTT 
GGGGATATTG TGCTTCTCAG AGCTTTACCT GTTCCACGAG CAAAGCATGT GAAACATGAA 
CTGGCTGAGA TCGTTTTCAA AGTTGGAAAA GTCATAGATC CAGTGACAGG AAAGCCCTGT 
GCTGGAACTA CCTACCTGGA GAGTCCGTTG AGTTCGGAAA CCACCCAGCT AAGCAAAAAT 
CTGGAAGAAC TCAATATCTC TTCAGCACAG TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MRPS17 ( NM_015969.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_057053.1 Homo sapiens mitochondrial ribosomal protein S17 (MRPS17), mRNA.

Price & Availability↑

CloneID	OHu29666
Clone ID Related Accession (Same CDS sequence)	NM_015969.2 , NM_015969.3
Accession Version	NM_015969.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 393bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-26
Organism	Homo sapiens(human)
Product	28S ribosomal protein S17, mitochondrial
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC092579.3. On Nov 25, 2018 this sequence version replaced NM_015969.2. ##Evidence-Data-START## Transcript exon combination :: SRR3476690.1051098.1, BC047445.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta MANE Ensembl match :: ENST00000285298.9/ ENSP00000285298.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGTCCGTAG TTCGCTCATC CGTCCATGCC AGATGGATTG TGGGGAAGGT GATTGGGACA 
AAAATGCAAA AGACTGCTAA AGTGAGAGTG ACCAGGCTTG TTCTGGATCC CTATTTATTA 
AAGTATTTTA ATAAGCGGAA AACCTACTTT GCTCACGATG CCCTTCAGCA GTGCACAGTT 
GGGGATATTG TGCTTCTCAG AGCTTTACCT GTTCCACGAG CAAAGCATGT GAAACATGAA 
CTGGCTGAGA TCGTTTTCAA AGTTGGAAAA GTCATAGATC CAGTGACAGG AAAGCCCTGT 
GCTGGAACTA CCTACCTGGA GAGTCCGTTG AGTTCGGAAA CCACCCAGCT AAGCAAAAAT 
CTGGAAGAAC TCAATATCTC TTCAGCACAG TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_057053.1
CDS	72..464
Translation	MSVVRSSVHARWIVGKVIGTKMQKTAKVRVTRLVLDPYLLKYFNKRKTYFAHDALQQCTVGDIVLLRALPVPRAKHVKHELAEIVFKVGKVIDPVTGKPCAGTTYLESPLSSETTQLSKNLEELNISSAQ

Target ORF information:

RefSeq Version	NM_015969.3
Organism	Homo sapiens(human)
Definition	Homo sapiens mitochondrial ribosomal protein S17 (MRPS17), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_015969.3

ORF Insert Sequence:

ATGTCCGTAG TTCGCTCATC CGTCCATGCC AGATGGATTG TGGGGAAGGT GATTGGGACA 
AAAATGCAAA AGACTGCTAA AGTGAGAGTG ACCAGGCTTG TTCTGGATCC CTATTTATTA 
AAGTATTTTA ATAAGCGGAA AACCTACTTT GCTCACGATG CCCTTCAGCA GTGCACAGTT 
GGGGATATTG TGCTTCTCAG AGCTTTACCT GTTCCACGAG CAAAGCATGT GAAACATGAA 
CTGGCTGAGA TCGTTTTCAA AGTTGGAAAA GTCATAGATC CAGTGACAGG AAAGCCCTGT 
GCTGGAACTA CCTACCTGGA GAGTCCGTTG AGTTCGGAAA CCACCCAGCT AAGCAAAAAT 
CTGGAAGAAC TCAATATCTC TTCAGCACAG TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Ribosome. The structure of the human mitochondrial ribosome.
Science (New York, N.Y.)348(6230)95-98(2015 Apr)
Amunts A,Brown A,Toots J,Scheres SHW,Ramakrishnan V

Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
PloS one5(9)e12862(2010 Sep)
Hendrickson SL,Lautenberger JA,Chinn LW,Malasky M,Sezgin E,Kingsley LA,Goedert JJ,Kirk GD,Gomperts ED,Buchbinder SP,Troyer JL,O'Brien SJ

Identification and characterization of over 100 mitochondrial ribosomal protein pseudogenes in the human genome.
Genomics81(5)468-80(2003 May)
Zhang Z,Gerstein M

The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders.
Genomics77(1-2)65-70(2001 Sep)
Kenmochi N,Suzuki T,Uechi T,Magoori M,Kuniba M,Higa S,Watanabe K,Tanaka T

Proteomic analysis of the mammalian mitochondrial ribosome. Identification of protein components in the 28 S small subunit.
The Journal of biological chemistry276(35)33181-95(2001 Aug)
Suzuki T,Terasaki M,Takemoto-Hori C,Hanada T,Ueda T,Wada A,Watanabe K

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MRPS17 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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