POMP cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	POMP
Entrez Gene ID	51371
Full Name	proteasome maturation protein
Synonyms	C13orf12,HSPC014,PNAS-110,UMP1
General protein information	Preferred Names proteasome maturation protein Names proteasome maturation protein 2510048O06Rik hUMP1 proteassemblin protein UMP1 homolog voltage-gated K channel beta subunit 4.1 voltage-gated potassium channel beta subunit 4.1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 13 Map Location: 13q12.3
Summary	The protein encoded by this gene is a molecular chaperone that binds 20S preproteasome components and is essential for 20S proteasome formation. The 20S proteasome is the proteolytically active component of the 26S proteasome complex. The encoded protein is degraded before the maturation of the 20S proteasome is complete. A variant in the 5' UTR of this gene has been associated with KLICK syndrome, a rare skin disorder.[provided by RefSeq, Aug 2010].
Disorder MIM:	613386
Disorder Html:	Keratosis linearis with ichthyosis congenita and sclerosing keratoderma, 601952 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_015932.6	NP_057016.1	proteasome maturation protein
NM_015932.5	NP_057016.1	proteasome maturation protein

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	POMP	NP_001238925.1
	POMP	XP_002800745.1
Mus musculus (house mouse)	Pomp	NP_079900.1
Homo sapiens (human)	POMP	NP_057016.1
Canis lupus familiaris (dog)	POMP	XP_534518.1
Rattus norvegicus (Norway rat)	LOC100911238	XP_006248902.1
Gallus gallus (chicken)	POMP	XP_004938825.1
Danio rerio (zebrafish)	pomp	NP_001003424.1
Xenopus tropicalis (tropical clawed frog)	pomp	NP_001005093.1
Bos taurus (cattle)	POMP	NP_001029548.1
Rattus norvegicus (Norway rat)	Pomp	NP_001094412.1

Gene Ontology
Bibliography

Related articles in PubMed

The proteasome maturation protein POMP increases proteasome assembly and activity in psoriatic lesional skin.
Zieba BA, Henry L, Lacroix M, Jema? M, Lavabre-Bertrand T, Meunier L, Coux O, Stoebner PE
Journal of dermatological science88(1)10-19(2017 Oct)

Architecture of the human interactome defines protein communities and disease networks.
Huttlin EL, Bruckner RJ, Paulo JA, Cannon JR, Ting L, Baltier K, Colby G, Gebreab F, Gygi MP, Parzen H, Szpyt J, Tam S, Zarraga G, Pontano-Vaites L, Swarup S, White AE, Schweppe DK, Rad R, Erickson BK, Obar RA, Guruharsha KG, Li K, Artavanis-Tsakonas S, Gygi SP, Harper JW
Nature545(7655)505-509(2017 05)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

MCM3AP and POMP Mutations Cause a DNA-Repair and DNA-Damage-Signaling Defect in an Immunodeficient Child
Title: MCM3AP and POMP Mutations Cause a DNA-Repair and DNA-Damage-Signaling Defect in an Immunodeficient Child.

studies validate a role for the NRF2/POMP axis in bortezomib resistance and identify NRF2 and POMP as potentially attractive targets for chemosensitization to this proteasome inhibitor
Title: The Nuclear Factor (Erythroid-derived 2)-like 2 and Proteasome Maturation Protein Axis Mediate Bortezomib Resistance in Multiple Myeloma.

microRNA-101 (miR-101) targets the proteasome maturation protein POMP, leading to impaired proteasome assembly and activity, and resulting in accumulation of p53 and cyclin-dependent kinase inhibitors, cell cycle arrest, and apoptosis.
Title: MicroRNA-101 Suppresses Tumor Cell Proliferation by Acting as an Endogenous Proteasome Inhibitor via Targeting the Proteasome Assembly Factor POMP.

Single-nucleotide polymorphisms in POMP gene is associated with breast cancer risk after menopausal hormone replacement therapy.
Title: Genetic modifiers of menopausal hormone replacement therapy and breast cancer risk: a genome-wide interaction study.

KLICK is caused by reduced levels of POMP, leading to proteasome insufficiency in differentiating keratinocytes
Title: siRNA silencing of proteasome maturation protein (POMP) activates the unfolded protein response and constitutes a model for KLICK genodermatosis.

The following POMP gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the POMP cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu18666	NM_015932.6 Latest version!	Homo sapiens proteasome maturation protein (POMP), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu18666	NM_015932.5	Homo sapiens proteasome maturation protein (POMP), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

POMP ( NM_015932.6 ) cDNA ORF clone, Homo sapiens(human) -> NP_057016.1 Homo sapiens proteasome maturation protein (POMP), mRNA.

Price & Availability↑

CloneID	OHu18666
Clone ID Related Accession (Same CDS sequence)	NM_015932.6 , NM_015932.5
Accession Version	NM_015932.6 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 426bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-25
Organism	Homo sapiens(human)
Product	proteasome maturation protein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from GU045555.1, BC014334.1, CD369437.1 and AL359454.7. This sequence is a reference standard in the RefSeqGene project. On Nov 22, 2018 this sequence version replaced NM_015932.5. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR3476690.185353.1, SRR1660803.110546.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000380842.5/ ENSP00000370222.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGAATGCCA GAGGACTTGG ATCTGAGCTA AAGGACAGTA TTCCAGTTAC TGAACTTTCA 
GCAAGTGGAC CTTTTGAAAG TCATGATCTT CTTCGGAAAG GTTTTTCTTG TGTGAAAAAT 
GAACTTTTGC CTAGTCATCC CCTTGAATTA TCAGAAAAAA ATTTCCAGCT CAACCAAGAT 
AAAATGAATT TTTCCACACT GAGAAACATT CAGGGTCTAT TTGCTCCGCT AAAATTACAG 
ATGGAATTCA AGGCAGTGCA GCAGGTTCAG CGTCTTCCAT TTCTTTCAAG CTCAAATCTT 
TCACTGGATG TTTTGAGGGG TAATGATGAG ACTATTGGAT TTGAGGATAT TCTTAATGAT 
CCATCACAAA GCGAAGTCAT GGGAGAGCCA CACTTGATGG TGGAATATAA ACTTGGTTTA 
CTGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_057016.1
CDS	56..481
Translation	MNARGLGSELKDSIPVTELSASGPFESHDLLRKGFSCVKNELLPSHPLELSEKNFQLNQDKMNFSTLRNIQGLFAPLKLQMEFKAVQQVQRLPFLSSSNLSLDVLRGNDETIGFEDILNDPSQSEVMGEPHLMVEYKLGLL

Target ORF information:

RefSeq Version	NM_015932.6
Organism	Homo sapiens(human)
Definition	Homo sapiens proteasome maturation protein (POMP), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_015932.6

ORF Insert Sequence:

ATGAATGCCA GAGGACTTGG ATCTGAGCTA AAGGACAGTA TTCCAGTTAC TGAACTTTCA 
GCAAGTGGAC CTTTTGAAAG TCATGATCTT CTTCGGAAAG GTTTTTCTTG TGTGAAAAAT 
GAACTTTTGC CTAGTCATCC CCTTGAATTA TCAGAAAAAA ATTTCCAGCT CAACCAAGAT 
AAAATGAATT TTTCCACACT GAGAAACATT CAGGGTCTAT TTGCTCCGCT AAAATTACAG 
ATGGAATTCA AGGCAGTGCA GCAGGTTCAG CGTCTTCCAT TTCTTTCAAG CTCAAATCTT 
TCACTGGATG TTTTGAGGGG TAATGATGAG ACTATTGGAT TTGAGGATAT TCTTAATGAT 
CCATCACAAA GCGAAGTCAT GGGAGAGCCA CACTTGATGG TGGAATATAA ACTTGGTTTA 
CTGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

POMP ( NM_015932.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_057016.1 Homo sapiens proteasome maturation protein (POMP), mRNA.

Price & Availability↑

CloneID	OHu18666
Clone ID Related Accession (Same CDS sequence)	NM_015932.6 , NM_015932.5
Accession Version	NM_015932.5	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 426bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-27
Organism	Homo sapiens(human)
Product	proteasome maturation protein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from GU045555.1, BC014334.1 and CD369437.1. This sequence is a reference standard in the RefSeqGene project. On Aug 28, 2010 this sequence version replaced NM_015932.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: GU045555.1, SRR1660807.6268.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

ATGAATGCCA GAGGACTTGG ATCTGAGCTA AAGGACAGTA TTCCAGTTAC TGAACTTTCA 
GCAAGTGGAC CTTTTGAAAG TCATGATCTT CTTCGGAAAG GTTTTTCTTG TGTGAAAAAT 
GAACTTTTGC CTAGTCATCC CCTTGAATTA TCAGAAAAAA ATTTCCAGCT CAACCAAGAT 
AAAATGAATT TTTCCACACT GAGAAACATT CAGGGTCTAT TTGCTCCGCT AAAATTACAG 
ATGGAATTCA AGGCAGTGCA GCAGGTTCAG CGTCTTCCAT TTCTTTCAAG CTCAAATCTT 
TCACTGGATG TTTTGAGGGG TAATGATGAG ACTATTGGAT TTGAGGATAT TCTTAATGAT 
CCATCACAAA GCGAAGTCAT GGGAGAGCCA CACTTGATGG TGGAATATAA ACTTGGTTTA 
CTGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_057016.1
CDS	182..607
Translation	MNARGLGSELKDSIPVTELSASGPFESHDLLRKGFSCVKNELLPSHPLELSEKNFQLNQDKMNFSTLRNIQGLFAPLKLQMEFKAVQQVQRLPFLSSSNLSLDVLRGNDETIGFEDILNDPSQSEVMGEPHLMVEYKLGLL

Target ORF information:

RefSeq Version	NM_015932.5
Organism	Homo sapiens(human)
Definition	Homo sapiens proteasome maturation protein (POMP), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_015932.5

ORF Insert Sequence:

ATGAATGCCA GAGGACTTGG ATCTGAGCTA AAGGACAGTA TTCCAGTTAC TGAACTTTCA 
GCAAGTGGAC CTTTTGAAAG TCATGATCTT CTTCGGAAAG GTTTTTCTTG TGTGAAAAAT 
GAACTTTTGC CTAGTCATCC CCTTGAATTA TCAGAAAAAA ATTTCCAGCT CAACCAAGAT 
AAAATGAATT TTTCCACACT GAGAAACATT CAGGGTCTAT TTGCTCCGCT AAAATTACAG 
ATGGAATTCA AGGCAGTGCA GCAGGTTCAG CGTCTTCCAT TTCTTTCAAG CTCAAATCTT 
TCACTGGATG TTTTGAGGGG TAATGATGAG ACTATTGGAT TTGAGGATAT TCTTAATGAT 
CCATCACAAA GCGAAGTCAT GGGAGAGCCA CACTTGATGG TGGAATATAA ACTTGGTTTA 
CTGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The proteasome maturation protein POMP increases proteasome assembly and activity in psoriatic lesional skin.
Journal of dermatological science88(1)10-19(2017 Oct)
Zieba BA,Henry L,Lacroix M,Jema? M,Lavabre-Bertrand T,Meunier L,Coux O,Stoebner PE

Architecture of the human interactome defines protein communities and disease networks.
Nature545(7655)505-509(2017 05)
Huttlin EL,Bruckner RJ,Paulo JA,Cannon JR,Ting L,Baltier K,Colby G,Gebreab F,Gygi MP,Parzen H,Szpyt J,Tam S,Zarraga G,Pontano-Vaites L,Swarup S,White AE,Schweppe DK,Rad R,Erickson BK,Obar RA,Guruharsha KG,Li K,Artavanis-Tsakonas S,Gygi SP,Harper JW

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POMP cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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