MBTPS2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	MBTPS2
Entrez Gene ID	51360
Full Name	membrane bound transcription factor peptidase, site 2
Synonyms	BRESEK,IFAP,KFSD,KFSDX,OLMSX,S2P
General protein information	Preferred Names membrane bound transcription factor peptidase, site 2 Names membrane-bound transcription factor site-2 protease SREBPs intramembrane protease endopeptidase S2P keratosis follicularis spinulosa decalvans membrane-bound transcription factor protease, site 2 site-2 protease sterol regulatory element-binding proteins intramembrane protease
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: X Map Location: Xp22.12
Summary	This gene encodes a intramembrane zinc metalloprotease, which is essential in development. This protease functions in the signal protein activation involved in sterol control of transcription and the ER stress response. Mutations in this gene have been associated with ichthyosis follicularis with atrichia and photophobia (IFAP syndrome); IFAP syndrome has been quantitatively linked to a reduction in cholesterol homeostasis and ER stress response.[provided by RefSeq, Aug 2009].
Disorder MIM:	300294
Disorder Html:	IFAP syndrome with or without BRESHECK syndrome, 308205 (3); Keratosis follicularis spinulosa decalvans, X-linked, 308800 (3); ?Olmsted syndrome, X-linked, 300918 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_015884.3	NP_056968.1	membrane-bound transcription factor site-2 protease
NM_015884.4	NP_056968.1	membrane-bound transcription factor site-2 protease

Pathways from BioSystems

Homologies

	MBTPS2	XP_001087019.2
Canis lupus familiaris (dog)	MBTPS2	XP_548891.3
Danio rerio (zebrafish)	mbtps2	NP_001020632.1
Drosophila melanogaster (fruit fly)	S2P	NP_610705.1
Arabidopsis thaliana (thale cress)	AT4G20310	NP_001154255.1
Caenorhabditis elegans (roundworm)	Y56A3A.2	NP_499537.2
Mus musculus (house mouse)	Mbtps2	NP_758511.1
Bos taurus (cattle)	MBTPS2	NP_001069449.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP011819	XP_320696.4
Xenopus tropicalis (tropical clawed frog)	mbtps2	NP_001017061.1
Homo sapiens (human)	MBTPS2	NP_056968.1
Pan troglodytes (chimpanzee)	MBTPS2	XP_003953992.1
Rattus norvegicus (Norway rat)	Mbtps2	NP_001030179.1
Gallus gallus (chicken)	MBTPS2	XP_425566.3

Gene Ontology
Bibliography

Related articles in PubMed

Understanding the phenotypic similarities between IFAP and Olmsted syndrome from a molecular perspective: the interaction of MBTPS2 and TRPV3.
Nemer G, Safi R, Kreidieh F, Usta J, Bergqvist C, Ballout F, Btadini W, Hamzeh N, Abbas O, Kibbi AG, Shimomura Y, Kurban M
Archives of dermatological research309(8)637-643(2017 Oct)

MBTPS2 mutations cause defective regulated intramembrane proteolysis in X-linked osteogenesis imperfecta.
Lindert U, Cabral WA, Ausavarat S, Tongkobpetch S, Ludin K, Barnes AM, Yeetong P, Weis M, Krabichler B, Srichomthong C, Makareeva EN, Janecke AR, Leikin S, R?thlisberger B, Rohrbach M, Kennerknecht I, Eyre DR, Suphapeetiporn K, Giunta C, Marini JC, Shotelersuk V
Nature communications711920(2016 Jul)

The site-2 protease.
Rawson RB
Biochimica et biophysica acta1828(12)2801-7(2013 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

S2P is essential owing to its activation of the sterol regulatory element binding proteins (SREBPs); in the absence of exogenous lipid, cells lacking S2P cannot survive. (Review)
Title: The site-2 protease.

In male patients, a genotype-phenotype correlation has begun to emerge, linking the site of the mutation in MBTPS2 with the clinical outcome described as IFAP syndrome.
Title: Genotype-phenotype correlations emerging from the identification of missense mutations in MBTPS2.

We demonstrate a novel association between an MBTPS2 mutation and an X-linked form of Olmsted syndrome.
Title: A missense mutation in the MBTPS2 gene underlies the X-linked form of Olmsted syndrome.

We report a fourth pedigree affected with Keratosis Follicularis Spinulosa Decalvans resulting from a recurrent missense mutation in the MBTPS2 gene.
Title: MBTPS2 mutation in a British pedigree with keratosis follicularis spinulosa decalvans.

Both intronic MBTPS2 c.671-9T>G and c.225-6T>A point mutations are ichthyosis follicularis, alopecia and photophobia syndrome causing mutations.
Title: Intronic mutations affecting splicing of MBTPS2 cause ichthyosis follicularis, alopecia and photophobia (IFAP) syndrome.

The following MBTPS2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MBTPS2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu17756	NM_015884.4 Latest version!	Homo sapiens membrane bound transcription factor peptidase, site 2 (MBTPS2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$300.30 $429.00
View Old Accession Versions >>
OHu17756	NM_015884.3	Homo sapiens membrane bound transcription factor peptidase, site 2 (MBTPS2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$300.30 $429.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

MBTPS2 ( NM_015884.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_056968.1 Homo sapiens membrane bound transcription factor peptidase, site 2 (MBTPS2), mRNA.

Price & Availability↑

CloneID	OHu17756
Clone ID Related Accession (Same CDS sequence)	NM_015884.3 , NM_015884.4
Accession Version	NM_015884.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1560bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	membrane-bound transcription factor site-2 protease
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from U73479.1, BX489533.1, AF019612.1, AK307143.1, AK056736.1 and AW204540.1. This sequence is a reference standard in the RefSeqGene project. On Aug 18, 2009 this sequence version replaced NM_015884.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660809.202900.1, SRR1803613.274627.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END##

ATGATTCCGG TGTCGCTGGT GGTGGTGGTG GTGGGTGGCT GGACTGTCGT CTACCTGACC 
GACTTGGTGC TGAAGTCATC TGTCTATTTT AAACATTCTT ATGAAGACTG GCTGGAAAAC 
AACGGACTGA GCATCTCCCC TTTCCACATA AGATGGCAAA CTGCTGTTTT CAATCGTGCC 
TTTTACAGTT GGGGACGGCG GAAAGCAAGG ATGCTTTACC AATGGTTCAA TTTTGGAATG 
GTGTTTGGCG TAATTGCCAT GTTTAGCTCA TTTTTTCTCC TTGGAAAAAC GCTGATGCAG 
ACTTTGGCAC AAATGATGGC TGACTCTCCC TCTTCTTATT CTTCCTCCTC TTCTTCCTCT 
TCCTCCTCTT CTTCCTCTTC CTCTTCTTCA TCTTCTTCCT CTTCCTCGCT TCACAATGAA 
CAGGTGTTAC AAGTTGTGGT TCCTGGTATA AATTTACCCG TCAATCAACT GACCTATTTC 
TTCACGGCAG TTCTCATTAG TGGTGTTGTA CATGAAATTG GACATGGGAT AGCAGCTATT 
AGGGAACAAG TTCGATTTAA TGGCTTTGGG ATTTTTCTCT TCATTATTTA TCCTGGAGCA 
TTTGTTGATC TGTTCACCAC TCATTTGCAA CTTATATCGC CAGTCCAGCA GCTAAGGATA 
TTTTGTGCAG GTATCTGGCA TAATTTTGTC CTTGCACTCT TGGGTATTTT AGCTCTTGTT 
CTCCTCCCAG TAATTCTCTT GCCATTTTAC TACACTGGAG TTGGGGTGCT CATCACTGAA 
GTTGCTGAGG ACTCTCCTGC CATTGGACCC AGAGGCCTTT TTGTGGGAGA CCTTGTCACC 
CATCTACAGG ATTGTCCTGT TACTAATGTG CAAGATTGGA ATGAATGTTT AGATACCATC 
GCCTATGAGC CCCAAATTGG TTACTGTATA AGTGCATCAA CTTTACAGCA GTTAAGTTTC 
CCAGTTAGAG CATACAAACG ACTAGATGGT TCAACTGAAT GCTGTAACAA TCACAGCCTC 
ACAGATGTGT GCTTTTCCTA CAGAAATAAT TTTAATAAGC GTTTGCATAC ATGTCTTCCT 
GCCCGGAAAG CAGTTGAAGC AACTCAAGTT TGCAGAACCA ATAAAGACTG TAAAAAAAGC 
TCAAGTTCAA GTTTCTGTAT AATACCTTCT TTGGAAACTC ACACTCGCTT AATAAAAGTA 
AAACACCCAC CTCAGATTGA TATGTTATAC GTAGGACATC CTCTGCATCT TCACTACACA 
GTGAGCATCA CCAGTTTTAT CCCACGTTTT AACTTTCTAA GCATAGATCT GCCAGTGGTT 
GTGGAGACAT TTGTCAAGTA CCTGATTTCC CTCTCAGGAG CTCTGGCTAT TGTTAATGCA 
GTACCCTGCT TTGCTTTGGA TGGACAATGG ATTCTAAACT CTTTCTTGGA TGCCACCCTT 
ACCTCAGTGA TTGGAGACAA TGATGTCAAA GATCTAATAG GGTTTTTCAT CTTGCTGGGT 
GGCAGTGTAC TTTTGGCTGC CAATGTGACC CTGGGACTCT GGATGGTTAC AGCACGGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_056968.1
CDS	198..1757
Translation	MIPVSLVVVVVGGWTVVYLTDLVLKSSVYFKHSYEDWLENNGLSISPFHIRWQTAVFNRAFYSWGRRKARMLYQWFNFGMVFGVIAMFSSFFLLGKTLMQTLAQMMADSPSSYSSSSSSSSSSSSSSSSSSSSSSSLHNEQVLQVVVPGINLPVNQLTYFFTAVLISGVVHEIGHGIAAIREQVRFNGFGIFLFIIYPGAFVDLFTTHLQLISPVQQLRIFCAGIWHNFVLALLGILALVLLPVILLPFYYTGVGVLITEVAEDSPAIGPRGLFVGDLVTHLQDCPVTNVQDWNECLDTIAYEPQIGYCISASTLQQLSFPVRAYKRLDGSTECCNNHSLTDVCFSYRNNFNKRLHTCLPARKAVEATQVCRTNKDCKKSSSSSFCIIPSLETHTRLIKVKHPPQIDMLYVGHPLHLHYTVSITSFIPRFNFLSIDLPVVVETFVKYLISLSGALAIVNAVPCFALDGQWILNSFLDATLTSVIGDNDVKDLIGFFILLGGSVLLAANVTLGLWMVTAR

Target ORF information:

RefSeq Version	NM_015884.3
Organism	Homo sapiens(human)
Definition	Homo sapiens membrane bound transcription factor peptidase, site 2 (MBTPS2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_015884.3

ORF Insert Sequence:

ATGATTCCGG TGTCGCTGGT GGTGGTGGTG GTGGGTGGCT GGACTGTCGT CTACCTGACC 
GACTTGGTGC TGAAGTCATC TGTCTATTTT AAACATTCTT ATGAAGACTG GCTGGAAAAC 
AACGGACTGA GCATCTCCCC TTTCCACATA AGATGGCAAA CTGCTGTTTT CAATCGTGCC 
TTTTACAGTT GGGGACGGCG GAAAGCAAGG ATGCTTTACC AATGGTTCAA TTTTGGAATG 
GTGTTTGGCG TAATTGCCAT GTTTAGCTCA TTTTTTCTCC TTGGAAAAAC GCTGATGCAG 
ACTTTGGCAC AAATGATGGC TGACTCTCCC TCTTCTTATT CTTCCTCCTC TTCTTCCTCT 
TCCTCCTCTT CTTCCTCTTC CTCTTCTTCA TCTTCTTCCT CTTCCTCGCT TCACAATGAA 
CAGGTGTTAC AAGTTGTGGT TCCTGGTATA AATTTACCCG TCAATCAACT GACCTATTTC 
TTCACGGCAG TTCTCATTAG TGGTGTTGTA CATGAAATTG GACATGGGAT AGCAGCTATT 
AGGGAACAAG TTCGATTTAA TGGCTTTGGG ATTTTTCTCT TCATTATTTA TCCTGGAGCA 
TTTGTTGATC TGTTCACCAC TCATTTGCAA CTTATATCGC CAGTCCAGCA GCTAAGGATA 
TTTTGTGCAG GTATCTGGCA TAATTTTGTC CTTGCACTCT TGGGTATTTT AGCTCTTGTT 
CTCCTCCCAG TAATTCTCTT GCCATTTTAC TACACTGGAG TTGGGGTGCT CATCACTGAA 
GTTGCTGAGG ACTCTCCTGC CATTGGACCC AGAGGCCTTT TTGTGGGAGA CCTTGTCACC 
CATCTACAGG ATTGTCCTGT TACTAATGTG CAAGATTGGA ATGAATGTTT AGATACCATC 
GCCTATGAGC CCCAAATTGG TTACTGTATA AGTGCATCAA CTTTACAGCA GTTAAGTTTC 
CCAGTTAGAG CATACAAACG ACTAGATGGT TCAACTGAAT GCTGTAACAA TCACAGCCTC 
ACAGATGTGT GCTTTTCCTA CAGAAATAAT TTTAATAAGC GTTTGCATAC ATGTCTTCCT 
GCCCGGAAAG CAGTTGAAGC AACTCAAGTT TGCAGAACCA ATAAAGACTG TAAAAAAAGC 
TCAAGTTCAA GTTTCTGTAT AATACCTTCT TTGGAAACTC ACACTCGCTT AATAAAAGTA 
AAACACCCAC CTCAGATTGA TATGTTATAC GTAGGACATC CTCTGCATCT TCACTACACA 
GTGAGCATCA CCAGTTTTAT CCCACGTTTT AACTTTCTAA GCATAGATCT GCCAGTGGTT 
GTGGAGACAT TTGTCAAGTA CCTGATTTCC CTCTCAGGAG CTCTGGCTAT TGTTAATGCA 
GTACCCTGCT TTGCTTTGGA TGGACAATGG ATTCTAAACT CTTTCTTGGA TGCCACCCTT 
ACCTCAGTGA TTGGAGACAA TGATGTCAAA GATCTAATAG GGTTTTTCAT CTTGCTGGGT 
GGCAGTGTAC TTTTGGCTGC CAATGTGACC CTGGGACTCT GGATGGTTAC AGCACGGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MBTPS2 ( NM_015884.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_056968.1 Homo sapiens membrane bound transcription factor peptidase, site 2 (MBTPS2), mRNA.

Price & Availability↑

CloneID	OHu17756
Clone ID Related Accession (Same CDS sequence)	NM_015884.3 , NM_015884.4
Accession Version	NM_015884.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1560bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-01
Organism	Homo sapiens(human)
Product	membrane-bound transcription factor site-2 protease
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BX489533.1, AF019612.1, AK307143.1, AK056736.1 and AW204540.1. This sequence is a reference standard in the RefSeqGene project. On Nov 23, 2018 this sequence version replaced NM_015884.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660809.202900.1, SRR1660809.65774.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000379484.10/ ENSP00000368798.5 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGATTCCGG TGTCGCTGGT GGTGGTGGTG GTGGGTGGCT GGACTGTCGT CTACCTGACC 
GACTTGGTGC TGAAGTCATC TGTCTATTTT AAACATTCTT ATGAAGACTG GCTGGAAAAC 
AACGGACTGA GCATCTCCCC TTTCCACATA AGATGGCAAA CTGCTGTTTT CAATCGTGCC 
TTTTACAGTT GGGGACGGCG GAAAGCAAGG ATGCTTTACC AATGGTTCAA TTTTGGAATG 
GTGTTTGGCG TAATTGCCAT GTTTAGCTCA TTTTTTCTCC TTGGAAAAAC GCTGATGCAG 
ACTTTGGCAC AAATGATGGC TGACTCTCCC TCTTCTTATT CTTCCTCCTC TTCTTCCTCT 
TCCTCCTCTT CTTCCTCTTC CTCTTCTTCA TCTTCTTCCT CTTCCTCGCT TCACAATGAA 
CAGGTGTTAC AAGTTGTGGT TCCTGGTATA AATTTACCCG TCAATCAACT GACCTATTTC 
TTCACGGCAG TTCTCATTAG TGGTGTTGTA CATGAAATTG GACATGGGAT AGCAGCTATT 
AGGGAACAAG TTCGATTTAA TGGCTTTGGG ATTTTTCTCT TCATTATTTA TCCTGGAGCA 
TTTGTTGATC TGTTCACCAC TCATTTGCAA CTTATATCGC CAGTCCAGCA GCTAAGGATA 
TTTTGTGCAG GTATCTGGCA TAATTTTGTC CTTGCACTCT TGGGTATTTT AGCTCTTGTT 
CTCCTCCCAG TAATTCTCTT GCCATTTTAC TACACTGGAG TTGGGGTGCT CATCACTGAA 
GTTGCTGAGG ACTCTCCTGC CATTGGACCC AGAGGCCTTT TTGTGGGAGA CCTTGTCACC 
CATCTACAGG ATTGTCCTGT TACTAATGTG CAAGATTGGA ATGAATGTTT AGATACCATC 
GCCTATGAGC CCCAAATTGG TTACTGTATA AGTGCATCAA CTTTACAGCA GTTAAGTTTC 
CCAGTTAGAG CATACAAACG ACTAGATGGT TCAACTGAAT GCTGTAACAA TCACAGCCTC 
ACAGATGTGT GCTTTTCCTA CAGAAATAAT TTTAATAAGC GTTTGCATAC ATGTCTTCCT 
GCCCGGAAAG CAGTTGAAGC AACTCAAGTT TGCAGAACCA ATAAAGACTG TAAAAAAAGC 
TCAAGTTCAA GTTTCTGTAT AATACCTTCT TTGGAAACTC ACACTCGCTT AATAAAAGTA 
AAACACCCAC CTCAGATTGA TATGTTATAC GTAGGACATC CTCTGCATCT TCACTACACA 
GTGAGCATCA CCAGTTTTAT CCCACGTTTT AACTTTCTAA GCATAGATCT GCCAGTGGTT 
GTGGAGACAT TTGTCAAGTA CCTGATTTCC CTCTCAGGAG CTCTGGCTAT TGTTAATGCA 
GTACCCTGCT TTGCTTTGGA TGGACAATGG ATTCTAAACT CTTTCTTGGA TGCCACCCTT 
ACCTCAGTGA TTGGAGACAA TGATGTCAAA GATCTAATAG GGTTTTTCAT CTTGCTGGGT 
GGCAGTGTAC TTTTGGCTGC CAATGTGACC CTGGGACTCT GGATGGTTAC AGCACGGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_056968.1
CDS	119..1678
Translation	MIPVSLVVVVVGGWTVVYLTDLVLKSSVYFKHSYEDWLENNGLSISPFHIRWQTAVFNRAFYSWGRRKARMLYQWFNFGMVFGVIAMFSSFFLLGKTLMQTLAQMMADSPSSYSSSSSSSSSSSSSSSSSSSSSSSLHNEQVLQVVVPGINLPVNQLTYFFTAVLISGVVHEIGHGIAAIREQVRFNGFGIFLFIIYPGAFVDLFTTHLQLISPVQQLRIFCAGIWHNFVLALLGILALVLLPVILLPFYYTGVGVLITEVAEDSPAIGPRGLFVGDLVTHLQDCPVTNVQDWNECLDTIAYEPQIGYCISASTLQQLSFPVRAYKRLDGSTECCNNHSLTDVCFSYRNNFNKRLHTCLPARKAVEATQVCRTNKDCKKSSSSSFCIIPSLETHTRLIKVKHPPQIDMLYVGHPLHLHYTVSITSFIPRFNFLSIDLPVVVETFVKYLISLSGALAIVNAVPCFALDGQWILNSFLDATLTSVIGDNDVKDLIGFFILLGGSVLLAANVTLGLWMVTAR

Target ORF information:

RefSeq Version	NM_015884.4
Organism	Homo sapiens(human)
Definition	Homo sapiens membrane bound transcription factor peptidase, site 2 (MBTPS2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_015884.4

ORF Insert Sequence:

ATGATTCCGG TGTCGCTGGT GGTGGTGGTG GTGGGTGGCT GGACTGTCGT CTACCTGACC 
GACTTGGTGC TGAAGTCATC TGTCTATTTT AAACATTCTT ATGAAGACTG GCTGGAAAAC 
AACGGACTGA GCATCTCCCC TTTCCACATA AGATGGCAAA CTGCTGTTTT CAATCGTGCC 
TTTTACAGTT GGGGACGGCG GAAAGCAAGG ATGCTTTACC AATGGTTCAA TTTTGGAATG 
GTGTTTGGCG TAATTGCCAT GTTTAGCTCA TTTTTTCTCC TTGGAAAAAC GCTGATGCAG 
ACTTTGGCAC AAATGATGGC TGACTCTCCC TCTTCTTATT CTTCCTCCTC TTCTTCCTCT 
TCCTCCTCTT CTTCCTCTTC CTCTTCTTCA TCTTCTTCCT CTTCCTCGCT TCACAATGAA 
CAGGTGTTAC AAGTTGTGGT TCCTGGTATA AATTTACCCG TCAATCAACT GACCTATTTC 
TTCACGGCAG TTCTCATTAG TGGTGTTGTA CATGAAATTG GACATGGGAT AGCAGCTATT 
AGGGAACAAG TTCGATTTAA TGGCTTTGGG ATTTTTCTCT TCATTATTTA TCCTGGAGCA 
TTTGTTGATC TGTTCACCAC TCATTTGCAA CTTATATCGC CAGTCCAGCA GCTAAGGATA 
TTTTGTGCAG GTATCTGGCA TAATTTTGTC CTTGCACTCT TGGGTATTTT AGCTCTTGTT 
CTCCTCCCAG TAATTCTCTT GCCATTTTAC TACACTGGAG TTGGGGTGCT CATCACTGAA 
GTTGCTGAGG ACTCTCCTGC CATTGGACCC AGAGGCCTTT TTGTGGGAGA CCTTGTCACC 
CATCTACAGG ATTGTCCTGT TACTAATGTG CAAGATTGGA ATGAATGTTT AGATACCATC 
GCCTATGAGC CCCAAATTGG TTACTGTATA AGTGCATCAA CTTTACAGCA GTTAAGTTTC 
CCAGTTAGAG CATACAAACG ACTAGATGGT TCAACTGAAT GCTGTAACAA TCACAGCCTC 
ACAGATGTGT GCTTTTCCTA CAGAAATAAT TTTAATAAGC GTTTGCATAC ATGTCTTCCT 
GCCCGGAAAG CAGTTGAAGC AACTCAAGTT TGCAGAACCA ATAAAGACTG TAAAAAAAGC 
TCAAGTTCAA GTTTCTGTAT AATACCTTCT TTGGAAACTC ACACTCGCTT AATAAAAGTA 
AAACACCCAC CTCAGATTGA TATGTTATAC GTAGGACATC CTCTGCATCT TCACTACACA 
GTGAGCATCA CCAGTTTTAT CCCACGTTTT AACTTTCTAA GCATAGATCT GCCAGTGGTT 
GTGGAGACAT TTGTCAAGTA CCTGATTTCC CTCTCAGGAG CTCTGGCTAT TGTTAATGCA 
GTACCCTGCT TTGCTTTGGA TGGACAATGG ATTCTAAACT CTTTCTTGGA TGCCACCCTT 
ACCTCAGTGA TTGGAGACAA TGATGTCAAA GATCTAATAG GGTTTTTCAT CTTGCTGGGT 
GGCAGTGTAC TTTTGGCTGC CAATGTGACC CTGGGACTCT GGATGGTTAC AGCACGGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Understanding the phenotypic similarities between IFAP and Olmsted syndrome from a molecular perspective: the interaction of MBTPS2 and TRPV3.
Archives of dermatological research309(8)637-643(2017 Oct)
Nemer G,Safi R,Kreidieh F,Usta J,Bergqvist C,Ballout F,Btadini W,Hamzeh N,Abbas O,Kibbi AG,Shimomura Y,Kurban M

MBTPS2 mutations cause defective regulated intramembrane proteolysis in X-linked osteogenesis imperfecta.
Nature communications711920(2016 Jul)
Lindert U,Cabral WA,Ausavarat S,Tongkobpetch S,Ludin K,Barnes AM,Yeetong P,Weis M,Krabichler B,Srichomthong C,Makareeva EN,Janecke AR,Leikin S,R?thlisberger B,Rohrbach M,Kennerknecht I,Eyre DR,Suphapeetiporn K,Giunta C,Marini JC,Shotelersuk V

The site-2 protease.
Biochimica et biophysica acta1828(12)2801-7(2013 Dec)
Rawson RB

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MBTPS2 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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