FZR1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	FZR1
Entrez Gene ID	51343
Full Name	fizzy and cell division cycle 20 related 1
Synonyms	CDC20C,CDH1,FZR,FZR2,HCDH,HCDH1
General protein information	Preferred Names fizzy and cell division cycle 20 related 1 Names fizzy-related protein homolog CDC20 homolog 1 CDC20-like 1b CDC20-like protein 1 cdh1/Hct1 homolog fizzy/cell division cycle 20 related 1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 19 Map Location: 19p13.3
Disorder MIM:	603619

mRNA and Protein(s)

mRNA	Protein	Name
XM_017026863.1	XP_016882352.1	fizzy-related protein homolog isoform X1
XM_005259573.5	XP_005259630.1	fizzy-related protein homolog isoform X2
NM_001136198.1	NP_001129670.1	fizzy-related protein homolog isoform 1
XM_005259573.4	XP_005259630.1	fizzy-related protein homolog isoform X2
NM_016263.3	NP_057347.2	fizzy-related protein homolog isoform 2
NM_001136197.1	NP_001129669.1	fizzy-related protein homolog isoform 3
XM_017026863.2	XP_016882352.1	fizzy-related protein homolog isoform X1
NM_016263.4	NP_057347.2	fizzy-related protein homolog isoform 2

Pathways from BioSystems

Homologies

Homo sapiens (human)	FZR1	NP_057347.2
Canis lupus familiaris (dog)	FZR1	XP_005633132.1
Rattus norvegicus (Norway rat)	Fzr1	NP_001101544.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP002114	XP_320924.5
Caenorhabditis elegans (roundworm)	fzr-1	NP_496075.1
Kluyveromyces lactis	KLLA0A08822g	XP_451387.1
Oryza sativa (rice)	Os01g0972900	NP_001045543.1
Mus musculus (house mouse)	Fzr1	NP_062731.1
Drosophila melanogaster (fruit fly)	rap	NP_524852.2
Eremothecium gossypii	AGOS_AFL007C	NP_985541.2
Schizosaccharomyces pombe (fission yeast)	srw1	NP_594674.1
Magnaporthe oryzae (rice blast fungus)	MGG_06892	XP_003709620.1
Xenopus tropicalis (tropical clawed frog)	fzr1	NP_001120001.1
	FZR1	XP_001117911.2
Bos taurus (cattle)	FZR1	NP_001032698.1
Gallus gallus (chicken)	CDH1-A	NP_001265019.1
Danio rerio (zebrafish)	fzr1	NP_956547.1
Saccharomyces cerevisiae (baker's yeast)	CDH1	NP_011512.1
Arabidopsis thaliana (thale cress)	FZR3	NP_196888.2
Neurospora crassa	NCU01269	XP_960747.1

Gene Ontology
Bibliography

Related articles in PubMed

A cell based screening approach for identifying protein degradation regulators.
Simanski S, Maloof ME, Sato TK, Cavett V, Caldwell Busby J, Ayad NG
Cell cycle (Georgetown, Tex.)16(10)940-946(2017 May)

The APC/C E3 Ligase Complex Activator FZR1 Restricts BRAF Oncogenic Function.
Wan L, Chen M, Cao J, Dai X, Yin Q, Zhang J, Song SJ, Lu Y, Liu J, Inuzuka H, Katon JM, Berry K, Fung J, Ng C, Liu P, Song MS, Xue L, Bronson RT, Kirschner MW, Cui R, Pandolfi PP, Wei W
Cancer discovery7(4)424-441(2017 04)

Anaphase-Promoting Complex Adaptor FZR1/CDH1 Blocks BRAF Signaling Both by Targeting BRAF for Proteolytic Degradation and by Disrupting BRAF Dimerization.
Zhang C, Bollag G
Cancer discovery7(4)356-358(2017 04)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

results suggest that reduction of FZR1 increases therapeutic sensitivity of B-ALL and that transient rather than tonic inhibition of FZR1 may be a therapeutic strategy.
Title: FZR1 loss increases sensitivity to DNA damage and consequently promotes murine and human B-cell acute leukemia.

FZR1 inhibits BRAF oncogenic functions via both APC-dependent proteolysis and APC-independent disruption of BRAF dimers, whereas hyperactivated ERK and CDK4 reciprocally suppress APC(FZR1) E3 ligase activity
Title: The APC/C E3 Ligase Complex Activator FZR1 Restricts BRAF Oncogenic Function.

These findings identify a dynamic interplay between FZR1 and BRAF with strong implications for cell-fate determination and the tumor suppressor role of FZR1
Title: Anaphase-Promoting Complex Adaptor FZR1/CDH1 Blocks BRAF Signaling Both by Targeting BRAF for Proteolytic Degradation and by Disrupting BRAF Dimerization.

APC/C and pRB interact with each other via the co-activator of APC/C, FZR1, providing an alternative pathway of regulation of G1 to S transition by pRB using a post-translational mechanism. Both pRB and FZR1 have complex roles and are implicated not only in regulation of cell proliferation but also in differentiation, quiescence, apoptosis, maintenance of chromosomal integrity and metabolism.
Title: APC/C and retinoblastoma interaction: cross-talk of retinoblastoma protein with the ubiquitin proteasome pathway.

APC(Cdh1) inactivation is the commitment point when cells lose the ability to return to quiescence and decide to progress through the cell cycle.
Title: Irreversible APC(Cdh1) Inactivation Underlies the Point of No Return for Cell-Cycle Entry.

The following FZR1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the FZR1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu07310	NM_016263.4 Latest version!	Homo sapiens fizzy and cell division cycle 20 related 1 (FZR1), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
OHu29175	NM_001136197.1 Latest version!	Homo sapiens fizzy and cell division cycle 20 related 1 (FZR1), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$237.30 $339.00
OHu29194	NM_001136198.1 Latest version!	Homo sapiens fizzy and cell division cycle 20 related 1 (FZR1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
OHu29194	XM_005259573.5 Latest version!	Homo sapiens fizzy and cell division cycle 20 related 1 (FZR1), transcript variant X3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
OHu88504	XM_017026863.2 Latest version!	Homo sapiens fizzy and cell division cycle 20 related 1 (FZR1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$307.30 $439.00
View Old Accession Versions >>
OHu29194	XM_005259573.4	Homo sapiens fizzy/cell division cycle 20 related 1 (FZR1), transcript variant X3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
OHu88504	XM_017026863.1	Homo sapiens fizzy/cell division cycle 20 related 1 (FZR1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$307.30 $439.00
OHu07310	NM_016263.3	Homo sapiens fizzy and cell division cycle 20 related 1 (FZR1), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

FZR1 ( NM_016263.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_057347.2 Homo sapiens fizzy and cell division cycle 20 related 1 (FZR1), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu07310
Clone ID Related Accession (Same CDS sequence)	NM_016263.3 , NM_016263.4
Accession Version	NM_016263.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1482bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-20
Organism	Homo sapiens(human)
Product	fizzy-related protein homolog isoform 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DB462260.1, BC013413.2, AF083810.1 and BC111760.1. On Oct 25, 2008 this sequence version replaced NM_016263.2. Transcript Variant: This variant (2) lacks a short in-frame segment in the 3' coding region compared to variant 1. The encoded protein (isoform 2) has a shorter C-terminus compared to isoform 1. This isoform is also known as isoform alpha. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF083810.1, SRR1803612.238138.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGACCAGG ACTATGAGCG GCGCCTGCTT CGCCAGATCG TCATCCAGAA TGAGAACACG 
ATGCCACGCG TCACAGAGAT GCGGCGGACC CTGACGCCTG CCAGCTCCCC AGTGTCCTCG 
CCCAGCAAGC ACGGAGACCG CTTCATCCCC TCCAGAGCCG GAGCCAACTG GAGCGTGAAC 
TTCCACAGGA TTAACGAGAA TGAGAAGTCT CCCAGTCAGA ACCGGAAAGC CAAGGACGCC 
ACCTCAGACA ACGGCAAAGA CGGCCTGGCC TACTCTGCCC TGCTCAAGAA TGAGCTGCTG 
GGTGCCGGCA TCGAGAAGGT GCAGGACCCG CAGACTGAGG ACCGCAGGCT GCAGCCCTCC 
ACGCCTGAGA AGAAGGGTCT GTTCACGTAT TCCCTTAGCA CCAAGCGCTC CAGCCCCGAT 
GACGGCAACG ATGTGTCTCC CTACTCCCTG TCTCCCGTCA GCAACAAGAG CCAGAAGCTG 
CTCCGGTCCC CCCGGAAACC CACCCGCAAG ATCTCCAAGA TCCCCTTCAA GGTGCTGGAC 
GCGCCCGAGC TGCAGGACGA CTTCTACCTC AATCTGGTGG ACTGGTCGTC CCTCAATGTG 
CTCAGCGTGG GGCTAGGCAC CTGCGTGTAC CTGTGGAGTG CCTGTACCAG CCAGGTGACG 
CGGCTCTGTG ACCTCTCAGT GGAAGGGGAC TCAGTGACCT CCGTGGGCTG GTCTGAGCGG 
GGGAACCTGG TGGCGGTGGG CACACACAAG GGCTTCGTGC AGATCTGGGA CGCAGCCGCA 
GGGAAGAAGC TGTCCATGTT GGAGGGCCAC ACGGCACGCG TCGGGGCGCT GGCCTGGAAT 
GCTGAGCAGC TGTCGTCCGG GAGCCGCGAC CGCATGATCC TGCAGAGGGA CATCCGCACC 
CCGCCACTGC AGTCGGAGCG GCGGCTGCAG GGCCACCGGC AGGAGGTGTG CGGGCTCAAG 
TGGTCCACAG ACCACCAGCT CCTCGCCTCG GGGGGCAACG ACAACAAGCT GCTGGTCTGG 
AATCACTCGA GCCTGAGCCC CGTGCAGCAG TACACGGAGC ACCTGGCGGC CGTGAAGGCC 
ATCGCCTGGT CCCCACATCA GCACGGGCTG CTGGCCTCGG GGGGCGGCAC AGCTGACCGC 
TGTATCCGCT TCTGGAACAC GCTGACAGGA CAACCACTGC AGTGTATCGA CACGGGCTCC 
CAAGTGTGCA ATCTGGCCTG GTCCAAGCAC GCCAACGAGC TGGTGAGCAC GCACGGCTAC 
TCACAGAACC AGATCCTTGT CTGGAAGTAC CCCTCCCTGA CCCAGGTGGC CAAGCTGACC 
GGGCACTCCT ACCGCGTGCT GTACCTGGCA ATGTCCCCTG ATGGGGAGGC CATCGTCACT 
GGTGCTGGAG ACGAGACCCT GAGGTTCTGG AACGTCTTTA GCAAAACCCG TTCGACAAAG 
GAGTCTGTGT CTGTGCTCAA CCTCTTCACC AGGATCCGGT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_057347.2
CDS	213..1694
Translation	MDQDYERRLLRQIVIQNENTMPRVTEMRRTLTPASSPVSSPSKHGDRFIPSRAGANWSVNFHRINENEKSPSQNRKAKDATSDNGKDGLAYSALLKNELLGAGIEKVQDPQTEDRRLQPSTPEKKGLFTYSLSTKRSSPDDGNDVSPYSLSPVSNKSQKLLRSPRKPTRKISKIPFKVLDAPELQDDFYLNLVDWSSLNVLSVGLGTCVYLWSACTSQVTRLCDLSVEGDSVTSVGWSERGNLVAVGTHKGFVQIWDAAAGKKLSMLEGHTARVGALAWNAEQLSSGSRDRMILQRDIRTPPLQSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPVQQYTEHLAAVKAIAWSPHQHGLLASGGGTADRCIRFWNTLTGQPLQCIDTGSQVCNLAWSKHANELVSTHGYSQNQILVWKYPSLTQVAKLTGHSYRVLYLAMSPDGEAIVTGAGDETLRFWNVFSKTRSTKESVSVLNLFTRIR

Target ORF information:

RefSeq Version	NM_016263.3
Organism	Homo sapiens(human)
Definition	Homo sapiens fizzy and cell division cycle 20 related 1 (FZR1), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_016263.3

ORF Insert Sequence:

ATGGACCAGG ACTATGAGCG GCGCCTGCTT CGCCAGATCG TCATCCAGAA TGAGAACACG 
ATGCCACGCG TCACAGAGAT GCGGCGGACC CTGACGCCTG CCAGCTCCCC AGTGTCCTCG 
CCCAGCAAGC ACGGAGACCG CTTCATCCCC TCCAGAGCCG GAGCCAACTG GAGCGTGAAC 
TTCCACAGGA TTAACGAGAA TGAGAAGTCT CCCAGTCAGA ACCGGAAAGC CAAGGACGCC 
ACCTCAGACA ACGGCAAAGA CGGCCTGGCC TACTCTGCCC TGCTCAAGAA TGAGCTGCTG 
GGTGCCGGCA TCGAGAAGGT GCAGGACCCG CAGACTGAGG ACCGCAGGCT GCAGCCCTCC 
ACGCCTGAGA AGAAGGGTCT GTTCACGTAT TCCCTTAGCA CCAAGCGCTC CAGCCCCGAT 
GACGGCAACG ATGTGTCTCC CTACTCCCTG TCTCCCGTCA GCAACAAGAG CCAGAAGCTG 
CTCCGGTCCC CCCGGAAACC CACCCGCAAG ATCTCCAAGA TCCCCTTCAA GGTGCTGGAC 
GCGCCCGAGC TGCAGGACGA CTTCTACCTC AATCTGGTGG ACTGGTCGTC CCTCAATGTG 
CTCAGCGTGG GGCTAGGCAC CTGCGTGTAC CTGTGGAGTG CCTGTACCAG CCAGGTGACG 
CGGCTCTGTG ACCTCTCAGT GGAAGGGGAC TCAGTGACCT CCGTGGGCTG GTCTGAGCGG 
GGGAACCTGG TGGCGGTGGG CACACACAAG GGCTTCGTGC AGATCTGGGA CGCAGCCGCA 
GGGAAGAAGC TGTCCATGTT GGAGGGCCAC ACGGCACGCG TCGGGGCGCT GGCCTGGAAT 
GCTGAGCAGC TGTCGTCCGG GAGCCGCGAC CGCATGATCC TGCAGAGGGA CATCCGCACC 
CCGCCACTGC AGTCGGAGCG GCGGCTGCAG GGCCACCGGC AGGAGGTGTG CGGGCTCAAG 
TGGTCCACAG ACCACCAGCT CCTCGCCTCG GGGGGCAACG ACAACAAGCT GCTGGTCTGG 
AATCACTCGA GCCTGAGCCC CGTGCAGCAG TACACGGAGC ACCTGGCGGC CGTGAAGGCC 
ATCGCCTGGT CCCCACATCA GCACGGGCTG CTGGCCTCGG GGGGCGGCAC AGCTGACCGC 
TGTATCCGCT TCTGGAACAC GCTGACAGGA CAACCACTGC AGTGTATCGA CACGGGCTCC 
CAAGTGTGCA ATCTGGCCTG GTCCAAGCAC GCCAACGAGC TGGTGAGCAC GCACGGCTAC 
TCACAGAACC AGATCCTTGT CTGGAAGTAC CCCTCCCTGA CCCAGGTGGC CAAGCTGACC 
GGGCACTCCT ACCGCGTGCT GTACCTGGCA ATGTCCCCTG ATGGGGAGGC CATCGTCACT 
GGTGCTGGAG ACGAGACCCT GAGGTTCTGG AACGTCTTTA GCAAAACCCG TTCGACAAAG 
GAGTCTGTGT CTGTGCTCAA CCTCTTCACC AGGATCCGGT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

FZR1 ( NM_016263.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_057347.2 Homo sapiens fizzy and cell division cycle 20 related 1 (FZR1), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu07310
Clone ID Related Accession (Same CDS sequence)	NM_016263.3 , NM_016263.4
Accession Version	NM_016263.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1482bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-03
Organism	Homo sapiens(human)
Product	fizzy-related protein homolog isoform 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DB462260.1, BC013413.2, AF083810.1, BC111760.1 and AC005787.1. On Jun 2, 2019 this sequence version replaced NM_016263.3. Transcript Variant: This variant (2) lacks a short in-frame segment in the 3' coding region compared to variant 1. The encoded protein (isoform 2) has a shorter C-terminus compared to isoform 1. This isoform is also known as isoform alpha. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF083810.1, SRR7410570.648852.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGACCAGG ACTATGAGCG GCGCCTGCTT CGCCAGATCG TCATCCAGAA TGAGAACACG 
ATGCCACGCG TCACAGAGAT GCGGCGGACC CTGACGCCTG CCAGCTCCCC AGTGTCCTCG 
CCCAGCAAGC ACGGAGACCG CTTCATCCCC TCCAGAGCCG GAGCCAACTG GAGCGTGAAC 
TTCCACAGGA TTAACGAGAA TGAGAAGTCT CCCAGTCAGA ACCGGAAAGC CAAGGACGCC 
ACCTCAGACA ACGGCAAAGA CGGCCTGGCC TACTCTGCCC TGCTCAAGAA TGAGCTGCTG 
GGTGCCGGCA TCGAGAAGGT GCAGGACCCG CAGACTGAGG ACCGCAGGCT GCAGCCCTCC 
ACGCCTGAGA AGAAGGGTCT GTTCACGTAT TCCCTTAGCA CCAAGCGCTC CAGCCCCGAT 
GACGGCAACG ATGTGTCTCC CTACTCCCTG TCTCCCGTCA GCAACAAGAG CCAGAAGCTG 
CTCCGGTCCC CCCGGAAACC CACCCGCAAG ATCTCCAAGA TCCCCTTCAA GGTGCTGGAC 
GCGCCCGAGC TGCAGGACGA CTTCTACCTC AATCTGGTGG ACTGGTCGTC CCTCAATGTG 
CTCAGCGTGG GGCTAGGCAC CTGCGTGTAC CTGTGGAGTG CCTGTACCAG CCAGGTGACG 
CGGCTCTGTG ACCTCTCAGT GGAAGGGGAC TCAGTGACCT CCGTGGGCTG GTCTGAGCGG 
GGGAACCTGG TGGCGGTGGG CACACACAAG GGCTTCGTGC AGATCTGGGA CGCAGCCGCA 
GGGAAGAAGC TGTCCATGTT GGAGGGCCAC ACGGCACGCG TCGGGGCGCT GGCCTGGAAT 
GCTGAGCAGC TGTCGTCCGG GAGCCGCGAC CGCATGATCC TGCAGAGGGA CATCCGCACC 
CCGCCACTGC AGTCGGAGCG GCGGCTGCAG GGCCACCGGC AGGAGGTGTG CGGGCTCAAG 
TGGTCCACAG ACCACCAGCT CCTCGCCTCG GGGGGCAACG ACAACAAGCT GCTGGTCTGG 
AATCACTCGA GCCTGAGCCC CGTGCAGCAG TACACGGAGC ACCTGGCGGC CGTGAAGGCC 
ATCGCCTGGT CCCCACATCA GCACGGGCTG CTGGCCTCGG GGGGCGGCAC AGCTGACCGC 
TGTATCCGCT TCTGGAACAC GCTGACAGGA CAACCACTGC AGTGTATCGA CACGGGCTCC 
CAAGTGTGCA ATCTGGCCTG GTCCAAGCAC GCCAACGAGC TGGTGAGCAC GCACGGCTAC 
TCACAGAACC AGATCCTTGT CTGGAAGTAC CCCTCCCTGA CCCAGGTGGC CAAGCTGACC 
GGGCACTCCT ACCGCGTGCT GTACCTGGCA ATGTCCCCTG ATGGGGAGGC CATCGTCACT 
GGTGCTGGAG ACGAGACCCT GAGGTTCTGG AACGTCTTTA GCAAAACCCG TTCGACAAAG 
GAGTCTGTGT CTGTGCTCAA CCTCTTCACC AGGATCCGGT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_057347.2
CDS	199..1680
Translation	MDQDYERRLLRQIVIQNENTMPRVTEMRRTLTPASSPVSSPSKHGDRFIPSRAGANWSVNFHRINENEKSPSQNRKAKDATSDNGKDGLAYSALLKNELLGAGIEKVQDPQTEDRRLQPSTPEKKGLFTYSLSTKRSSPDDGNDVSPYSLSPVSNKSQKLLRSPRKPTRKISKIPFKVLDAPELQDDFYLNLVDWSSLNVLSVGLGTCVYLWSACTSQVTRLCDLSVEGDSVTSVGWSERGNLVAVGTHKGFVQIWDAAAGKKLSMLEGHTARVGALAWNAEQLSSGSRDRMILQRDIRTPPLQSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPVQQYTEHLAAVKAIAWSPHQHGLLASGGGTADRCIRFWNTLTGQPLQCIDTGSQVCNLAWSKHANELVSTHGYSQNQILVWKYPSLTQVAKLTGHSYRVLYLAMSPDGEAIVTGAGDETLRFWNVFSKTRSTKESVSVLNLFTRIR

Target ORF information:

RefSeq Version	NM_016263.4
Organism	Homo sapiens(human)
Definition	Homo sapiens fizzy and cell division cycle 20 related 1 (FZR1), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_016263.4

ORF Insert Sequence:

ATGGACCAGG ACTATGAGCG GCGCCTGCTT CGCCAGATCG TCATCCAGAA TGAGAACACG 
ATGCCACGCG TCACAGAGAT GCGGCGGACC CTGACGCCTG CCAGCTCCCC AGTGTCCTCG 
CCCAGCAAGC ACGGAGACCG CTTCATCCCC TCCAGAGCCG GAGCCAACTG GAGCGTGAAC 
TTCCACAGGA TTAACGAGAA TGAGAAGTCT CCCAGTCAGA ACCGGAAAGC CAAGGACGCC 
ACCTCAGACA ACGGCAAAGA CGGCCTGGCC TACTCTGCCC TGCTCAAGAA TGAGCTGCTG 
GGTGCCGGCA TCGAGAAGGT GCAGGACCCG CAGACTGAGG ACCGCAGGCT GCAGCCCTCC 
ACGCCTGAGA AGAAGGGTCT GTTCACGTAT TCCCTTAGCA CCAAGCGCTC CAGCCCCGAT 
GACGGCAACG ATGTGTCTCC CTACTCCCTG TCTCCCGTCA GCAACAAGAG CCAGAAGCTG 
CTCCGGTCCC CCCGGAAACC CACCCGCAAG ATCTCCAAGA TCCCCTTCAA GGTGCTGGAC 
GCGCCCGAGC TGCAGGACGA CTTCTACCTC AATCTGGTGG ACTGGTCGTC CCTCAATGTG 
CTCAGCGTGG GGCTAGGCAC CTGCGTGTAC CTGTGGAGTG CCTGTACCAG CCAGGTGACG 
CGGCTCTGTG ACCTCTCAGT GGAAGGGGAC TCAGTGACCT CCGTGGGCTG GTCTGAGCGG 
GGGAACCTGG TGGCGGTGGG CACACACAAG GGCTTCGTGC AGATCTGGGA CGCAGCCGCA 
GGGAAGAAGC TGTCCATGTT GGAGGGCCAC ACGGCACGCG TCGGGGCGCT GGCCTGGAAT 
GCTGAGCAGC TGTCGTCCGG GAGCCGCGAC CGCATGATCC TGCAGAGGGA CATCCGCACC 
CCGCCACTGC AGTCGGAGCG GCGGCTGCAG GGCCACCGGC AGGAGGTGTG CGGGCTCAAG 
TGGTCCACAG ACCACCAGCT CCTCGCCTCG GGGGGCAACG ACAACAAGCT GCTGGTCTGG 
AATCACTCGA GCCTGAGCCC CGTGCAGCAG TACACGGAGC ACCTGGCGGC CGTGAAGGCC 
ATCGCCTGGT CCCCACATCA GCACGGGCTG CTGGCCTCGG GGGGCGGCAC AGCTGACCGC 
TGTATCCGCT TCTGGAACAC GCTGACAGGA CAACCACTGC AGTGTATCGA CACGGGCTCC 
CAAGTGTGCA ATCTGGCCTG GTCCAAGCAC GCCAACGAGC TGGTGAGCAC GCACGGCTAC 
TCACAGAACC AGATCCTTGT CTGGAAGTAC CCCTCCCTGA CCCAGGTGGC CAAGCTGACC 
GGGCACTCCT ACCGCGTGCT GTACCTGGCA ATGTCCCCTG ATGGGGAGGC CATCGTCACT 
GGTGCTGGAG ACGAGACCCT GAGGTTCTGG AACGTCTTTA GCAAAACCCG TTCGACAAAG 
GAGTCTGTGT CTGTGCTCAA CCTCTTCACC AGGATCCGGT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

FZR1 ( NM_001136197.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001129669.1 Homo sapiens fizzy and cell division cycle 20 related 1 (FZR1), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu29175
Clone ID Related Accession (Same CDS sequence)	NM_001136197.1
Accession Version	NM_001136197.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1215bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Homo sapiens(human)
Product	fizzy-related protein homolog isoform 3
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC013413.2, AF433157.1, AF083810.1 and AB033068.1. Transcript Variant: This variant (3) skips multiple exons in the central coding region and lacks a short in-frame segment in the 3' coding region compared to variant 1. The encoded protein (isoform 3) lacks a WD40 repeat and has a shorter C-terminus compared to isoform 1. This isoform is also known as isoform beta. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB013463.1, AF433157.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END##

ATGGACCAGG ACTATGAGCG GCGCCTGCTT CGCCAGATCG TCATCCAGAA TGAGAACACG 
ATGCCACGCG TCACAGAGAT GCGGCGGACC CTGACGCCTG CCAGCTCCCC AGTGTCCTCG 
CCCAGCAAGC ACGGAGACCG CTTCATCCCC TCCAGAGCCG GAGCCAACTG GAGCGTGAAC 
TTCCACAGGA TTAACGAGAA TGAGAAGTCT CCCAGTCAGA ACCGGAAAGC CAAGGACGCC 
ACCTCAGACA ACGGCAAAGA CGGCCTGGCC TACTCTGCCC TGCTCAAGAA TGAGCTGCTG 
GGTGCCGGCA TCGAGAAGGT GCAGGACCCG CAGACTGAGG ACCGCAGGCT GCAGCCCTCC 
ACGCCTGAGA AGAAGGGTCT GTTCACGGTG ACGCGGCTCT GTGACCTCTC AGTGGAAGGG 
GACTCAGTGA CCTCCGTGGG CTGGTCTGAG CGGGGGAACC TGGTGGCGGT GGGCACACAC 
AAGGGCTTCG TGCAGATCTG GGACGCAGCC GCAGGGAAGA AGCTGTCCAT GTTGGAGGGC 
CACACGGCAC GCGTCGGGGC GCTGGCCTGG AATGCTGAGC AGCTGTCGTC CGGGAGCCGC 
GACCGCATGA TCCTGCAGAG GGACATCCGC ACCCCGCCAC TGCAGTCGGA GCGGCGGCTG 
CAGGGCCACC GGCAGGAGGT GTGCGGGCTC AAGTGGTCCA CAGACCACCA GCTCCTCGCC 
TCGGGGGGCA ACGACAACAA GCTGCTGGTC TGGAATCACT CGAGCCTGAG CCCCGTGCAG 
CAGTACACGG AGCACCTGGC GGCCGTGAAG GCCATCGCCT GGTCCCCACA TCAGCACGGG 
CTGCTGGCCT CGGGGGGCGG CACAGCTGAC CGCTGTATCC GCTTCTGGAA CACGCTGACA 
GGACAACCAC TGCAGTGTAT CGACACGGGC TCCCAAGTGT GCAATCTGGC CTGGTCCAAG 
CACGCCAACG AGCTGGTGAG CACGCACGGC TACTCACAGA ACCAGATCCT TGTCTGGAAG 
TACCCCTCCC TGACCCAGGT GGCCAAGCTG ACCGGGCACT CCTACCGCGT GCTGTACCTG 
GCAATGTCCC CTGATGGGGA GGCCATCGTC ACTGGTGCTG GAGACGAGAC CCTGAGGTTC 
TGGAACGTCT TTAGCAAAAC CCGTTCGACA AAGGAGTCTG TGTCTGTGCT CAACCTCTTC 
ACCAGGATCC GGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001129669.1
CDS	35..1249
Translation	MDQDYERRLLRQIVIQNENTMPRVTEMRRTLTPASSPVSSPSKHGDRFIPSRAGANWSVNFHRINENEKSPSQNRKAKDATSDNGKDGLAYSALLKNELLGAGIEKVQDPQTEDRRLQPSTPEKKGLFTVTRLCDLSVEGDSVTSVGWSERGNLVAVGTHKGFVQIWDAAAGKKLSMLEGHTARVGALAWNAEQLSSGSRDRMILQRDIRTPPLQSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPVQQYTEHLAAVKAIAWSPHQHGLLASGGGTADRCIRFWNTLTGQPLQCIDTGSQVCNLAWSKHANELVSTHGYSQNQILVWKYPSLTQVAKLTGHSYRVLYLAMSPDGEAIVTGAGDETLRFWNVFSKTRSTKESVSVLNLFTRIR

Target ORF information:

RefSeq Version	NM_001136197.1
Organism	Homo sapiens(human)
Definition	Homo sapiens fizzy and cell division cycle 20 related 1 (FZR1), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001136197.1

ORF Insert Sequence:

ATGGACCAGG ACTATGAGCG GCGCCTGCTT CGCCAGATCG TCATCCAGAA TGAGAACACG 
ATGCCACGCG TCACAGAGAT GCGGCGGACC CTGACGCCTG CCAGCTCCCC AGTGTCCTCG 
CCCAGCAAGC ACGGAGACCG CTTCATCCCC TCCAGAGCCG GAGCCAACTG GAGCGTGAAC 
TTCCACAGGA TTAACGAGAA TGAGAAGTCT CCCAGTCAGA ACCGGAAAGC CAAGGACGCC 
ACCTCAGACA ACGGCAAAGA CGGCCTGGCC TACTCTGCCC TGCTCAAGAA TGAGCTGCTG 
GGTGCCGGCA TCGAGAAGGT GCAGGACCCG CAGACTGAGG ACCGCAGGCT GCAGCCCTCC 
ACGCCTGAGA AGAAGGGTCT GTTCACGGTG ACGCGGCTCT GTGACCTCTC AGTGGAAGGG 
GACTCAGTGA CCTCCGTGGG CTGGTCTGAG CGGGGGAACC TGGTGGCGGT GGGCACACAC 
AAGGGCTTCG TGCAGATCTG GGACGCAGCC GCAGGGAAGA AGCTGTCCAT GTTGGAGGGC 
CACACGGCAC GCGTCGGGGC GCTGGCCTGG AATGCTGAGC AGCTGTCGTC CGGGAGCCGC 
GACCGCATGA TCCTGCAGAG GGACATCCGC ACCCCGCCAC TGCAGTCGGA GCGGCGGCTG 
CAGGGCCACC GGCAGGAGGT GTGCGGGCTC AAGTGGTCCA CAGACCACCA GCTCCTCGCC 
TCGGGGGGCA ACGACAACAA GCTGCTGGTC TGGAATCACT CGAGCCTGAG CCCCGTGCAG 
CAGTACACGG AGCACCTGGC GGCCGTGAAG GCCATCGCCT GGTCCCCACA TCAGCACGGG 
CTGCTGGCCT CGGGGGGCGG CACAGCTGAC CGCTGTATCC GCTTCTGGAA CACGCTGACA 
GGACAACCAC TGCAGTGTAT CGACACGGGC TCCCAAGTGT GCAATCTGGC CTGGTCCAAG 
CACGCCAACG AGCTGGTGAG CACGCACGGC TACTCACAGA ACCAGATCCT TGTCTGGAAG 
TACCCCTCCC TGACCCAGGT GGCCAAGCTG ACCGGGCACT CCTACCGCGT GCTGTACCTG 
GCAATGTCCC CTGATGGGGA GGCCATCGTC ACTGGTGCTG GAGACGAGAC CCTGAGGTTC 
TGGAACGTCT TTAGCAAAAC CCGTTCGACA AAGGAGTCTG TGTCTGTGCT CAACCTCTTC 
ACCAGGATCC GGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

FZR1 ( NM_001136198.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001129670.1 Homo sapiens fizzy and cell division cycle 20 related 1 (FZR1), transcript variant 1, mRNA.

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CloneID	OHu29194
Clone ID Related Accession (Same CDS sequence)	XM_005259573.5 , NM_001136198.1 , XM_005259573.4
Accession Version	NM_001136198.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1491bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Homo sapiens(human)
Product	fizzy-related protein homolog isoform 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC013413.2, AB013462.1, AF083810.1 and AB033068.1. Transcript Variant: This variant (1) encodes the longest isoform. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB013462.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END##

ATGGACCAGG ACTATGAGCG GCGCCTGCTT CGCCAGATCG TCATCCAGAA TGAGAACACG 
ATGCCACGCG TCACAGAGAT GCGGCGGACC CTGACGCCTG CCAGCTCCCC AGTGTCCTCG 
CCCAGCAAGC ACGGAGACCG CTTCATCCCC TCCAGAGCCG GAGCCAACTG GAGCGTGAAC 
TTCCACAGGA TTAACGAGAA TGAGAAGTCT CCCAGTCAGA ACCGGAAAGC CAAGGACGCC 
ACCTCAGACA ACGGCAAAGA CGGCCTGGCC TACTCTGCCC TGCTCAAGAA TGAGCTGCTG 
GGTGCCGGCA TCGAGAAGGT GCAGGACCCG CAGACTGAGG ACCGCAGGCT GCAGCCCTCC 
ACGCCTGAGA AGAAGGGTCT GTTCACGTAT TCCCTTAGCA CCAAGCGCTC CAGCCCCGAT 
GACGGCAACG ATGTGTCTCC CTACTCCCTG TCTCCCGTCA GCAACAAGAG CCAGAAGCTG 
CTCCGGTCCC CCCGGAAACC CACCCGCAAG ATCTCCAAGA TCCCCTTCAA GGTGCTGGAC 
GCGCCCGAGC TGCAGGACGA CTTCTACCTC AATCTGGTGG ACTGGTCGTC CCTCAATGTG 
CTCAGCGTGG GGCTAGGCAC CTGCGTGTAC CTGTGGAGTG CCTGTACCAG CCAGGTGACG 
CGGCTCTGTG ACCTCTCAGT GGAAGGGGAC TCAGTGACCT CCGTGGGCTG GTCTGAGCGG 
GGGAACCTGG TGGCGGTGGG CACACACAAG GGCTTCGTGC AGATCTGGGA CGCAGCCGCA 
GGGAAGAAGC TGTCCATGTT GGAGGGCCAC ACGGCACGCG TCGGGGCGCT GGCCTGGAAT 
GCTGAGCAGC TGTCGTCCGG GAGCCGCGAC CGCATGATCC TGCAGAGGGA CATCCGCACC 
CCGCCACTGC AGTCGGAGCG GCGGCTGCAG GGCCACCGGC AGGAGGTGTG CGGGCTCAAG 
TGGTCCACAG ACCACCAGCT CCTCGCCTCG GGGGGCAACG ACAACAAGCT GCTGGTCTGG 
AATCACTCGA GCCTGAGCCC CGTGCAGCAG TACACGGAGC ACCTGGCGGC CGTGAAGGCC 
ATCGCCTGGT CCCCACATCA GCACGGGCTG CTGGCCTCGG GGGGCGGCAC AGCTGACCGC 
TGTATCCGCT TCTGGAACAC GCTGACAGGA CAACCACTGC AGTGTATCGA CACGGGCTCC 
CAAGTGTGCA ATCTGGCCTG GTCCAAGCAC GCCAACGAGC TGGTGAGCAC GCACGGCTAC 
TCACAGAACC AGATCCTTGT CTGGAAGTAC CCCTCCCTGA CCCAGGTGGC CAAGCTGACC 
GGGCACTCCT ACCGCGTGCT GTACCTGGCA ATGTCCCCTG ATGGGGAGGC CATCGTCACT 
GGTGCTGGAG ACGAGACCCT GAGGTTCTGG AACGTCTTTA GCAAAACCCG TTCGACAAAG 
GTAAAGTGGG AGTCTGTGTC TGTGCTCAAC CTCTTCACCA GGATCCGGTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001129670.1
CDS	35..1525
Translation	MDQDYERRLLRQIVIQNENTMPRVTEMRRTLTPASSPVSSPSKHGDRFIPSRAGANWSVNFHRINENEKSPSQNRKAKDATSDNGKDGLAYSALLKNELLGAGIEKVQDPQTEDRRLQPSTPEKKGLFTYSLSTKRSSPDDGNDVSPYSLSPVSNKSQKLLRSPRKPTRKISKIPFKVLDAPELQDDFYLNLVDWSSLNVLSVGLGTCVYLWSACTSQVTRLCDLSVEGDSVTSVGWSERGNLVAVGTHKGFVQIWDAAAGKKLSMLEGHTARVGALAWNAEQLSSGSRDRMILQRDIRTPPLQSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPVQQYTEHLAAVKAIAWSPHQHGLLASGGGTADRCIRFWNTLTGQPLQCIDTGSQVCNLAWSKHANELVSTHGYSQNQILVWKYPSLTQVAKLTGHSYRVLYLAMSPDGEAIVTGAGDETLRFWNVFSKTRSTKVKWESVSVLNLFTRIR

Target ORF information:

RefSeq Version	NM_001136198.1
Organism	Homo sapiens(human)
Definition	Homo sapiens fizzy and cell division cycle 20 related 1 (FZR1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001136198.1

ORF Insert Sequence:

ATGGACCAGG ACTATGAGCG GCGCCTGCTT CGCCAGATCG TCATCCAGAA TGAGAACACG 
ATGCCACGCG TCACAGAGAT GCGGCGGACC CTGACGCCTG CCAGCTCCCC AGTGTCCTCG 
CCCAGCAAGC ACGGAGACCG CTTCATCCCC TCCAGAGCCG GAGCCAACTG GAGCGTGAAC 
TTCCACAGGA TTAACGAGAA TGAGAAGTCT CCCAGTCAGA ACCGGAAAGC CAAGGACGCC 
ACCTCAGACA ACGGCAAAGA CGGCCTGGCC TACTCTGCCC TGCTCAAGAA TGAGCTGCTG 
GGTGCCGGCA TCGAGAAGGT GCAGGACCCG CAGACTGAGG ACCGCAGGCT GCAGCCCTCC 
ACGCCTGAGA AGAAGGGTCT GTTCACGTAT TCCCTTAGCA CCAAGCGCTC CAGCCCCGAT 
GACGGCAACG ATGTGTCTCC CTACTCCCTG TCTCCCGTCA GCAACAAGAG CCAGAAGCTG 
CTCCGGTCCC CCCGGAAACC CACCCGCAAG ATCTCCAAGA TCCCCTTCAA GGTGCTGGAC 
GCGCCCGAGC TGCAGGACGA CTTCTACCTC AATCTGGTGG ACTGGTCGTC CCTCAATGTG 
CTCAGCGTGG GGCTAGGCAC CTGCGTGTAC CTGTGGAGTG CCTGTACCAG CCAGGTGACG 
CGGCTCTGTG ACCTCTCAGT GGAAGGGGAC TCAGTGACCT CCGTGGGCTG GTCTGAGCGG 
GGGAACCTGG TGGCGGTGGG CACACACAAG GGCTTCGTGC AGATCTGGGA CGCAGCCGCA 
GGGAAGAAGC TGTCCATGTT GGAGGGCCAC ACGGCACGCG TCGGGGCGCT GGCCTGGAAT 
GCTGAGCAGC TGTCGTCCGG GAGCCGCGAC CGCATGATCC TGCAGAGGGA CATCCGCACC 
CCGCCACTGC AGTCGGAGCG GCGGCTGCAG GGCCACCGGC AGGAGGTGTG CGGGCTCAAG 
TGGTCCACAG ACCACCAGCT CCTCGCCTCG GGGGGCAACG ACAACAAGCT GCTGGTCTGG 
AATCACTCGA GCCTGAGCCC CGTGCAGCAG TACACGGAGC ACCTGGCGGC CGTGAAGGCC 
ATCGCCTGGT CCCCACATCA GCACGGGCTG CTGGCCTCGG GGGGCGGCAC AGCTGACCGC 
TGTATCCGCT TCTGGAACAC GCTGACAGGA CAACCACTGC AGTGTATCGA CACGGGCTCC 
CAAGTGTGCA ATCTGGCCTG GTCCAAGCAC GCCAACGAGC TGGTGAGCAC GCACGGCTAC 
TCACAGAACC AGATCCTTGT CTGGAAGTAC CCCTCCCTGA CCCAGGTGGC CAAGCTGACC 
GGGCACTCCT ACCGCGTGCT GTACCTGGCA ATGTCCCCTG ATGGGGAGGC CATCGTCACT 
GGTGCTGGAG ACGAGACCCT GAGGTTCTGG AACGTCTTTA GCAAAACCCG TTCGACAAAG 
GTAAAGTGGG AGTCTGTGTC TGTGCTCAAC CTCTTCACCA GGATCCGGTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

FZR1 ( XM_005259573.5 ) cDNA ORF clone, Homo sapiens(human) -> XP_005259630.1 Homo sapiens fizzy and cell division cycle 20 related 1 (FZR1), transcript variant X3, mRNA.

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CloneID	OHu29194
Clone ID Related Accession (Same CDS sequence)	XM_005259573.5 , NM_001136198.1 , XM_005259573.4
Accession Version	XM_005259573.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1491bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	fizzy-related protein homolog isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000019.10) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_005259573.4. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGACCAGG ACTATGAGCG GCGCCTGCTT CGCCAGATCG TCATCCAGAA TGAGAACACG 
ATGCCACGCG TCACAGAGAT GCGGCGGACC CTGACGCCTG CCAGCTCCCC AGTGTCCTCG 
CCCAGCAAGC ACGGAGACCG CTTCATCCCC TCCAGAGCCG GAGCCAACTG GAGCGTGAAC 
TTCCACAGGA TTAACGAGAA TGAGAAGTCT CCCAGTCAGA ACCGGAAAGC CAAGGACGCC 
ACCTCAGACA ACGGCAAAGA CGGCCTGGCC TACTCTGCCC TGCTCAAGAA TGAGCTGCTG 
GGTGCCGGCA TCGAGAAGGT GCAGGACCCG CAGACTGAGG ACCGCAGGCT GCAGCCCTCC 
ACGCCTGAGA AGAAGGGTCT GTTCACGTAT TCCCTTAGCA CCAAGCGCTC CAGCCCCGAT 
GACGGCAACG ATGTGTCTCC CTACTCCCTG TCTCCCGTCA GCAACAAGAG CCAGAAGCTG 
CTCCGGTCCC CCCGGAAACC CACCCGCAAG ATCTCCAAGA TCCCCTTCAA GGTGCTGGAC 
GCGCCCGAGC TGCAGGACGA CTTCTACCTC AATCTGGTGG ACTGGTCGTC CCTCAATGTG 
CTCAGCGTGG GGCTAGGCAC CTGCGTGTAC CTGTGGAGTG CCTGTACCAG CCAGGTGACG 
CGGCTCTGTG ACCTCTCAGT GGAAGGGGAC TCAGTGACCT CCGTGGGCTG GTCTGAGCGG 
GGGAACCTGG TGGCGGTGGG CACACACAAG GGCTTCGTGC AGATCTGGGA CGCAGCCGCA 
GGGAAGAAGC TGTCCATGTT GGAGGGCCAC ACGGCACGCG TCGGGGCGCT GGCCTGGAAT 
GCTGAGCAGC TGTCGTCCGG GAGCCGCGAC CGCATGATCC TGCAGAGGGA CATCCGCACC 
CCGCCACTGC AGTCGGAGCG GCGGCTGCAG GGCCACCGGC AGGAGGTGTG CGGGCTCAAG 
TGGTCCACAG ACCACCAGCT CCTCGCCTCG GGGGGCAACG ACAACAAGCT GCTGGTCTGG 
AATCACTCGA GCCTGAGCCC CGTGCAGCAG TACACGGAGC ACCTGGCGGC CGTGAAGGCC 
ATCGCCTGGT CCCCACATCA GCACGGGCTG CTGGCCTCGG GGGGCGGCAC AGCTGACCGC 
TGTATCCGCT TCTGGAACAC GCTGACAGGA CAACCACTGC AGTGTATCGA CACGGGCTCC 
CAAGTGTGCA ATCTGGCCTG GTCCAAGCAC GCCAACGAGC TGGTGAGCAC GCACGGCTAC 
TCACAGAACC AGATCCTTGT CTGGAAGTAC CCCTCCCTGA CCCAGGTGGC CAAGCTGACC 
GGGCACTCCT ACCGCGTGCT GTACCTGGCA ATGTCCCCTG ATGGGGAGGC CATCGTCACT 
GGTGCTGGAG ACGAGACCCT GAGGTTCTGG AACGTCTTTA GCAAAACCCG TTCGACAAAG 
GTAAAGTGGG AGTCTGTGTC TGTGCTCAAC CTCTTCACCA GGATCCGGTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_005259630.1
CDS	247..1737
Translation	MDQDYERRLLRQIVIQNENTMPRVTEMRRTLTPASSPVSSPSKHGDRFIPSRAGANWSVNFHRINENEKSPSQNRKAKDATSDNGKDGLAYSALLKNELLGAGIEKVQDPQTEDRRLQPSTPEKKGLFTYSLSTKRSSPDDGNDVSPYSLSPVSNKSQKLLRSPRKPTRKISKIPFKVLDAPELQDDFYLNLVDWSSLNVLSVGLGTCVYLWSACTSQVTRLCDLSVEGDSVTSVGWSERGNLVAVGTHKGFVQIWDAAAGKKLSMLEGHTARVGALAWNAEQLSSGSRDRMILQRDIRTPPLQSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPVQQYTEHLAAVKAIAWSPHQHGLLASGGGTADRCIRFWNTLTGQPLQCIDTGSQVCNLAWSKHANELVSTHGYSQNQILVWKYPSLTQVAKLTGHSYRVLYLAMSPDGEAIVTGAGDETLRFWNVFSKTRSTKVKWESVSVLNLFTRIR

Target ORF information:

RefSeq Version	XM_005259573.5
Organism	Homo sapiens(human)
Definition	Homo sapiens fizzy and cell division cycle 20 related 1 (FZR1), transcript variant X3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005259573.5

ORF Insert Sequence:

ATGGACCAGG ACTATGAGCG GCGCCTGCTT CGCCAGATCG TCATCCAGAA TGAGAACACG 
ATGCCACGCG TCACAGAGAT GCGGCGGACC CTGACGCCTG CCAGCTCCCC AGTGTCCTCG 
CCCAGCAAGC ACGGAGACCG CTTCATCCCC TCCAGAGCCG GAGCCAACTG GAGCGTGAAC 
TTCCACAGGA TTAACGAGAA TGAGAAGTCT CCCAGTCAGA ACCGGAAAGC CAAGGACGCC 
ACCTCAGACA ACGGCAAAGA CGGCCTGGCC TACTCTGCCC TGCTCAAGAA TGAGCTGCTG 
GGTGCCGGCA TCGAGAAGGT GCAGGACCCG CAGACTGAGG ACCGCAGGCT GCAGCCCTCC 
ACGCCTGAGA AGAAGGGTCT GTTCACGTAT TCCCTTAGCA CCAAGCGCTC CAGCCCCGAT 
GACGGCAACG ATGTGTCTCC CTACTCCCTG TCTCCCGTCA GCAACAAGAG CCAGAAGCTG 
CTCCGGTCCC CCCGGAAACC CACCCGCAAG ATCTCCAAGA TCCCCTTCAA GGTGCTGGAC 
GCGCCCGAGC TGCAGGACGA CTTCTACCTC AATCTGGTGG ACTGGTCGTC CCTCAATGTG 
CTCAGCGTGG GGCTAGGCAC CTGCGTGTAC CTGTGGAGTG CCTGTACCAG CCAGGTGACG 
CGGCTCTGTG ACCTCTCAGT GGAAGGGGAC TCAGTGACCT CCGTGGGCTG GTCTGAGCGG 
GGGAACCTGG TGGCGGTGGG CACACACAAG GGCTTCGTGC AGATCTGGGA CGCAGCCGCA 
GGGAAGAAGC TGTCCATGTT GGAGGGCCAC ACGGCACGCG TCGGGGCGCT GGCCTGGAAT 
GCTGAGCAGC TGTCGTCCGG GAGCCGCGAC CGCATGATCC TGCAGAGGGA CATCCGCACC 
CCGCCACTGC AGTCGGAGCG GCGGCTGCAG GGCCACCGGC AGGAGGTGTG CGGGCTCAAG 
TGGTCCACAG ACCACCAGCT CCTCGCCTCG GGGGGCAACG ACAACAAGCT GCTGGTCTGG 
AATCACTCGA GCCTGAGCCC CGTGCAGCAG TACACGGAGC ACCTGGCGGC CGTGAAGGCC 
ATCGCCTGGT CCCCACATCA GCACGGGCTG CTGGCCTCGG GGGGCGGCAC AGCTGACCGC 
TGTATCCGCT TCTGGAACAC GCTGACAGGA CAACCACTGC AGTGTATCGA CACGGGCTCC 
CAAGTGTGCA ATCTGGCCTG GTCCAAGCAC GCCAACGAGC TGGTGAGCAC GCACGGCTAC 
TCACAGAACC AGATCCTTGT CTGGAAGTAC CCCTCCCTGA CCCAGGTGGC CAAGCTGACC 
GGGCACTCCT ACCGCGTGCT GTACCTGGCA ATGTCCCCTG ATGGGGAGGC CATCGTCACT 
GGTGCTGGAG ACGAGACCCT GAGGTTCTGG AACGTCTTTA GCAAAACCCG TTCGACAAAG 
GTAAAGTGGG AGTCTGTGTC TGTGCTCAAC CTCTTCACCA GGATCCGGTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

FZR1 ( XM_005259573.4 ) cDNA ORF clone, Homo sapiens(human) -> XP_005259630.1 Homo sapiens fizzy/cell division cycle 20 related 1 (FZR1), transcript variant X3, mRNA.

Price & Availability↑

CloneID	OHu29194
Clone ID Related Accession (Same CDS sequence)	XM_005259573.5 , NM_001136198.1 , XM_005259573.4
Accession Version	XM_005259573.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1491bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	fizzy-related protein homolog isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000019.10) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_005259573.3. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGACCAGG ACTATGAGCG GCGCCTGCTT CGCCAGATCG TCATCCAGAA TGAGAACACG 
ATGCCACGCG TCACAGAGAT GCGGCGGACC CTGACGCCTG CCAGCTCCCC AGTGTCCTCG 
CCCAGCAAGC ACGGAGACCG CTTCATCCCC TCCAGAGCCG GAGCCAACTG GAGCGTGAAC 
TTCCACAGGA TTAACGAGAA TGAGAAGTCT CCCAGTCAGA ACCGGAAAGC CAAGGACGCC 
ACCTCAGACA ACGGCAAAGA CGGCCTGGCC TACTCTGCCC TGCTCAAGAA TGAGCTGCTG 
GGTGCCGGCA TCGAGAAGGT GCAGGACCCG CAGACTGAGG ACCGCAGGCT GCAGCCCTCC 
ACGCCTGAGA AGAAGGGTCT GTTCACGTAT TCCCTTAGCA CCAAGCGCTC CAGCCCCGAT 
GACGGCAACG ATGTGTCTCC CTACTCCCTG TCTCCCGTCA GCAACAAGAG CCAGAAGCTG 
CTCCGGTCCC CCCGGAAACC CACCCGCAAG ATCTCCAAGA TCCCCTTCAA GGTGCTGGAC 
GCGCCCGAGC TGCAGGACGA CTTCTACCTC AATCTGGTGG ACTGGTCGTC CCTCAATGTG 
CTCAGCGTGG GGCTAGGCAC CTGCGTGTAC CTGTGGAGTG CCTGTACCAG CCAGGTGACG 
CGGCTCTGTG ACCTCTCAGT GGAAGGGGAC TCAGTGACCT CCGTGGGCTG GTCTGAGCGG 
GGGAACCTGG TGGCGGTGGG CACACACAAG GGCTTCGTGC AGATCTGGGA CGCAGCCGCA 
GGGAAGAAGC TGTCCATGTT GGAGGGCCAC ACGGCACGCG TCGGGGCGCT GGCCTGGAAT 
GCTGAGCAGC TGTCGTCCGG GAGCCGCGAC CGCATGATCC TGCAGAGGGA CATCCGCACC 
CCGCCACTGC AGTCGGAGCG GCGGCTGCAG GGCCACCGGC AGGAGGTGTG CGGGCTCAAG 
TGGTCCACAG ACCACCAGCT CCTCGCCTCG GGGGGCAACG ACAACAAGCT GCTGGTCTGG 
AATCACTCGA GCCTGAGCCC CGTGCAGCAG TACACGGAGC ACCTGGCGGC CGTGAAGGCC 
ATCGCCTGGT CCCCACATCA GCACGGGCTG CTGGCCTCGG GGGGCGGCAC AGCTGACCGC 
TGTATCCGCT TCTGGAACAC GCTGACAGGA CAACCACTGC AGTGTATCGA CACGGGCTCC 
CAAGTGTGCA ATCTGGCCTG GTCCAAGCAC GCCAACGAGC TGGTGAGCAC GCACGGCTAC 
TCACAGAACC AGATCCTTGT CTGGAAGTAC CCCTCCCTGA CCCAGGTGGC CAAGCTGACC 
GGGCACTCCT ACCGCGTGCT GTACCTGGCA ATGTCCCCTG ATGGGGAGGC CATCGTCACT 
GGTGCTGGAG ACGAGACCCT GAGGTTCTGG AACGTCTTTA GCAAAACCCG TTCGACAAAG 
GTAAAGTGGG AGTCTGTGTC TGTGCTCAAC CTCTTCACCA GGATCCGGTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_005259630.1
CDS	395..1885
Translation	MDQDYERRLLRQIVIQNENTMPRVTEMRRTLTPASSPVSSPSKHGDRFIPSRAGANWSVNFHRINENEKSPSQNRKAKDATSDNGKDGLAYSALLKNELLGAGIEKVQDPQTEDRRLQPSTPEKKGLFTYSLSTKRSSPDDGNDVSPYSLSPVSNKSQKLLRSPRKPTRKISKIPFKVLDAPELQDDFYLNLVDWSSLNVLSVGLGTCVYLWSACTSQVTRLCDLSVEGDSVTSVGWSERGNLVAVGTHKGFVQIWDAAAGKKLSMLEGHTARVGALAWNAEQLSSGSRDRMILQRDIRTPPLQSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPVQQYTEHLAAVKAIAWSPHQHGLLASGGGTADRCIRFWNTLTGQPLQCIDTGSQVCNLAWSKHANELVSTHGYSQNQILVWKYPSLTQVAKLTGHSYRVLYLAMSPDGEAIVTGAGDETLRFWNVFSKTRSTKVKWESVSVLNLFTRIR

Target ORF information:

RefSeq Version	XM_005259573.4
Organism	Homo sapiens(human)
Definition	Homo sapiens fizzy/cell division cycle 20 related 1 (FZR1), transcript variant X3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005259573.4

ORF Insert Sequence:

ATGGACCAGG ACTATGAGCG GCGCCTGCTT CGCCAGATCG TCATCCAGAA TGAGAACACG 
ATGCCACGCG TCACAGAGAT GCGGCGGACC CTGACGCCTG CCAGCTCCCC AGTGTCCTCG 
CCCAGCAAGC ACGGAGACCG CTTCATCCCC TCCAGAGCCG GAGCCAACTG GAGCGTGAAC 
TTCCACAGGA TTAACGAGAA TGAGAAGTCT CCCAGTCAGA ACCGGAAAGC CAAGGACGCC 
ACCTCAGACA ACGGCAAAGA CGGCCTGGCC TACTCTGCCC TGCTCAAGAA TGAGCTGCTG 
GGTGCCGGCA TCGAGAAGGT GCAGGACCCG CAGACTGAGG ACCGCAGGCT GCAGCCCTCC 
ACGCCTGAGA AGAAGGGTCT GTTCACGTAT TCCCTTAGCA CCAAGCGCTC CAGCCCCGAT 
GACGGCAACG ATGTGTCTCC CTACTCCCTG TCTCCCGTCA GCAACAAGAG CCAGAAGCTG 
CTCCGGTCCC CCCGGAAACC CACCCGCAAG ATCTCCAAGA TCCCCTTCAA GGTGCTGGAC 
GCGCCCGAGC TGCAGGACGA CTTCTACCTC AATCTGGTGG ACTGGTCGTC CCTCAATGTG 
CTCAGCGTGG GGCTAGGCAC CTGCGTGTAC CTGTGGAGTG CCTGTACCAG CCAGGTGACG 
CGGCTCTGTG ACCTCTCAGT GGAAGGGGAC TCAGTGACCT CCGTGGGCTG GTCTGAGCGG 
GGGAACCTGG TGGCGGTGGG CACACACAAG GGCTTCGTGC AGATCTGGGA CGCAGCCGCA 
GGGAAGAAGC TGTCCATGTT GGAGGGCCAC ACGGCACGCG TCGGGGCGCT GGCCTGGAAT 
GCTGAGCAGC TGTCGTCCGG GAGCCGCGAC CGCATGATCC TGCAGAGGGA CATCCGCACC 
CCGCCACTGC AGTCGGAGCG GCGGCTGCAG GGCCACCGGC AGGAGGTGTG CGGGCTCAAG 
TGGTCCACAG ACCACCAGCT CCTCGCCTCG GGGGGCAACG ACAACAAGCT GCTGGTCTGG 
AATCACTCGA GCCTGAGCCC CGTGCAGCAG TACACGGAGC ACCTGGCGGC CGTGAAGGCC 
ATCGCCTGGT CCCCACATCA GCACGGGCTG CTGGCCTCGG GGGGCGGCAC AGCTGACCGC 
TGTATCCGCT TCTGGAACAC GCTGACAGGA CAACCACTGC AGTGTATCGA CACGGGCTCC 
CAAGTGTGCA ATCTGGCCTG GTCCAAGCAC GCCAACGAGC TGGTGAGCAC GCACGGCTAC 
TCACAGAACC AGATCCTTGT CTGGAAGTAC CCCTCCCTGA CCCAGGTGGC CAAGCTGACC 
GGGCACTCCT ACCGCGTGCT GTACCTGGCA ATGTCCCCTG ATGGGGAGGC CATCGTCACT 
GGTGCTGGAG ACGAGACCCT GAGGTTCTGG AACGTCTTTA GCAAAACCCG TTCGACAAAG 
GTAAAGTGGG AGTCTGTGTC TGTGCTCAAC CTCTTCACCA GGATCCGGTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

FZR1 ( XM_017026863.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016882352.1 Homo sapiens fizzy/cell division cycle 20 related 1 (FZR1), transcript variant X1, mRNA.

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CloneID	OHu88504
Clone ID Related Accession (Same CDS sequence)	XM_017026863.1 , XM_017026863.2
Accession Version	XM_017026863.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1587bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	fizzy-related protein homolog isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000019.10) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCTGGGT CGTGTTCTGG CGTGTGGAGG GCCGCGCTGG TTCGTCCCTC ACCTGTTGAT 
GCGCTAACCT TGCCGCGGGC CGAGCCCTGC CTCGCCATGG ACCAGGACTA TGAGCGGCGC 
CTGCTTCGCC AGATCGTCAT CCAGAATGAG AACACGATGC CACGCGTCAC AGAGATGCGG 
CGGACCCTGA CGCCTGCCAG CTCCCCAGTG TCCTCGCCCA GCAAGCACGG AGACCGCTTC 
ATCCCCTCCA GAGCCGGAGC CAACTGGAGC GTGAACTTCC ACAGGATTAA CGAGAATGAG 
AAGTCTCCCA GTCAGAACCG GAAAGCCAAG GACGCCACCT CAGACAACGG CAAAGACGGC 
CTGGCCTACT CTGCCCTGCT CAAGAATGAG CTGCTGGGTG CCGGCATCGA GAAGGTGCAG 
GACCCGCAGA CTGAGGACCG CAGGCTGCAG CCCTCCACGC CTGAGAAGAA GGGTCTGTTC 
ACGTATTCCC TTAGCACCAA GCGCTCCAGC CCCGATGACG GCAACGATGT GTCTCCCTAC 
TCCCTGTCTC CCGTCAGCAA CAAGAGCCAG AAGCTGCTCC GGTCCCCCCG GAAACCCACC 
CGCAAGATCT CCAAGATCCC CTTCAAGGTG CTGGACGCGC CCGAGCTGCA GGACGACTTC 
TACCTCAATC TGGTGGACTG GTCGTCCCTC AATGTGCTCA GCGTGGGGCT AGGCACCTGC 
GTGTACCTGT GGAGTGCCTG TACCAGCCAG GTGACGCGGC TCTGTGACCT CTCAGTGGAA 
GGGGACTCAG TGACCTCCGT GGGCTGGTCT GAGCGGGGGA ACCTGGTGGC GGTGGGCACA 
CACAAGGGCT TCGTGCAGAT CTGGGACGCA GCCGCAGGGA AGAAGCTGTC CATGTTGGAG 
GGCCACACGG CACGCGTCGG GGCGCTGGCC TGGAATGCTG AGCAGCTGTC GTCCGGGAGC 
CGCGACCGCA TGATCCTGCA GAGGGACATC CGCACCCCGC CACTGCAGTC GGAGCGGCGG 
CTGCAGGGCC ACCGGCAGGA GGTGTGCGGG CTCAAGTGGT CCACAGACCA CCAGCTCCTC 
GCCTCGGGGG GCAACGACAA CAAGCTGCTG GTCTGGAATC ACTCGAGCCT GAGCCCCGTG 
CAGCAGTACA CGGAGCACCT GGCGGCCGTG AAGGCCATCG CCTGGTCCCC ACATCAGCAC 
GGGCTGCTGG CCTCGGGGGG CGGCACAGCT GACCGCTGTA TCCGCTTCTG GAACACGCTG 
ACAGGACAAC CACTGCAGTG TATCGACACG GGCTCCCAAG TGTGCAATCT GGCCTGGTCC 
AAGCACGCCA ACGAGCTGGT GAGCACGCAC GGCTACTCAC AGAACCAGAT CCTTGTCTGG 
AAGTACCCCT CCCTGACCCA GGTGGCCAAG CTGACCGGGC ACTCCTACCG CGTGCTGTAC 
CTGGCAATGT CCCCTGATGG GGAGGCCATC GTCACTGGTG CTGGAGACGA GACCCTGAGG 
TTCTGGAACG TCTTTAGCAA AACCCGTTCG ACAAAGGTAA AGTGGGAGTC TGTGTCTGTG 
CTCAACCTCT TCACCAGGAT CCGGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016882352.1
CDS	643..2229
Translation	MAGSCSGVWRAALVRPSPVDALTLPRAEPCLAMDQDYERRLLRQIVIQNENTMPRVTEMRRTLTPASSPVSSPSKHGDRFIPSRAGANWSVNFHRINENEKSPSQNRKAKDATSDNGKDGLAYSALLKNELLGAGIEKVQDPQTEDRRLQPSTPEKKGLFTYSLSTKRSSPDDGNDVSPYSLSPVSNKSQKLLRSPRKPTRKISKIPFKVLDAPELQDDFYLNLVDWSSLNVLSVGLGTCVYLWSACTSQVTRLCDLSVEGDSVTSVGWSERGNLVAVGTHKGFVQIWDAAAGKKLSMLEGHTARVGALAWNAEQLSSGSRDRMILQRDIRTPPLQSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPVQQYTEHLAAVKAIAWSPHQHGLLASGGGTADRCIRFWNTLTGQPLQCIDTGSQVCNLAWSKHANELVSTHGYSQNQILVWKYPSLTQVAKLTGHSYRVLYLAMSPDGEAIVTGAGDETLRFWNVFSKTRSTKVKWESVSVLNLFTRIR

Target ORF information:

RefSeq Version	XM_017026863.1
Organism	Homo sapiens(human)
Definition	Homo sapiens fizzy/cell division cycle 20 related 1 (FZR1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017026863.1

ORF Insert Sequence:

ATGGCTGGGT CGTGTTCTGG CGTGTGGAGG GCCGCGCTGG TTCGTCCCTC ACCTGTTGAT 
GCGCTAACCT TGCCGCGGGC CGAGCCCTGC CTCGCCATGG ACCAGGACTA TGAGCGGCGC 
CTGCTTCGCC AGATCGTCAT CCAGAATGAG AACACGATGC CACGCGTCAC AGAGATGCGG 
CGGACCCTGA CGCCTGCCAG CTCCCCAGTG TCCTCGCCCA GCAAGCACGG AGACCGCTTC 
ATCCCCTCCA GAGCCGGAGC CAACTGGAGC GTGAACTTCC ACAGGATTAA CGAGAATGAG 
AAGTCTCCCA GTCAGAACCG GAAAGCCAAG GACGCCACCT CAGACAACGG CAAAGACGGC 
CTGGCCTACT CTGCCCTGCT CAAGAATGAG CTGCTGGGTG CCGGCATCGA GAAGGTGCAG 
GACCCGCAGA CTGAGGACCG CAGGCTGCAG CCCTCCACGC CTGAGAAGAA GGGTCTGTTC 
ACGTATTCCC TTAGCACCAA GCGCTCCAGC CCCGATGACG GCAACGATGT GTCTCCCTAC 
TCCCTGTCTC CCGTCAGCAA CAAGAGCCAG AAGCTGCTCC GGTCCCCCCG GAAACCCACC 
CGCAAGATCT CCAAGATCCC CTTCAAGGTG CTGGACGCGC CCGAGCTGCA GGACGACTTC 
TACCTCAATC TGGTGGACTG GTCGTCCCTC AATGTGCTCA GCGTGGGGCT AGGCACCTGC 
GTGTACCTGT GGAGTGCCTG TACCAGCCAG GTGACGCGGC TCTGTGACCT CTCAGTGGAA 
GGGGACTCAG TGACCTCCGT GGGCTGGTCT GAGCGGGGGA ACCTGGTGGC GGTGGGCACA 
CACAAGGGCT TCGTGCAGAT CTGGGACGCA GCCGCAGGGA AGAAGCTGTC CATGTTGGAG 
GGCCACACGG CACGCGTCGG GGCGCTGGCC TGGAATGCTG AGCAGCTGTC GTCCGGGAGC 
CGCGACCGCA TGATCCTGCA GAGGGACATC CGCACCCCGC CACTGCAGTC GGAGCGGCGG 
CTGCAGGGCC ACCGGCAGGA GGTGTGCGGG CTCAAGTGGT CCACAGACCA CCAGCTCCTC 
GCCTCGGGGG GCAACGACAA CAAGCTGCTG GTCTGGAATC ACTCGAGCCT GAGCCCCGTG 
CAGCAGTACA CGGAGCACCT GGCGGCCGTG AAGGCCATCG CCTGGTCCCC ACATCAGCAC 
GGGCTGCTGG CCTCGGGGGG CGGCACAGCT GACCGCTGTA TCCGCTTCTG GAACACGCTG 
ACAGGACAAC CACTGCAGTG TATCGACACG GGCTCCCAAG TGTGCAATCT GGCCTGGTCC 
AAGCACGCCA ACGAGCTGGT GAGCACGCAC GGCTACTCAC AGAACCAGAT CCTTGTCTGG 
AAGTACCCCT CCCTGACCCA GGTGGCCAAG CTGACCGGGC ACTCCTACCG CGTGCTGTAC 
CTGGCAATGT CCCCTGATGG GGAGGCCATC GTCACTGGTG CTGGAGACGA GACCCTGAGG 
TTCTGGAACG TCTTTAGCAA AACCCGTTCG ACAAAGGTAA AGTGGGAGTC TGTGTCTGTG 
CTCAACCTCT TCACCAGGAT CCGGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

FZR1 ( XM_017026863.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_016882352.1 Homo sapiens fizzy and cell division cycle 20 related 1 (FZR1), transcript variant X1, mRNA.

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CloneID	OHu88504
Clone ID Related Accession (Same CDS sequence)	XM_017026863.1 , XM_017026863.2
Accession Version	XM_017026863.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1587bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	fizzy-related protein homolog isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000019.10) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_017026863.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCTGGGT CGTGTTCTGG CGTGTGGAGG GCCGCGCTGG TTCGTCCCTC ACCTGTTGAT 
GCGCTAACCT TGCCGCGGGC CGAGCCCTGC CTCGCCATGG ACCAGGACTA TGAGCGGCGC 
CTGCTTCGCC AGATCGTCAT CCAGAATGAG AACACGATGC CACGCGTCAC AGAGATGCGG 
CGGACCCTGA CGCCTGCCAG CTCCCCAGTG TCCTCGCCCA GCAAGCACGG AGACCGCTTC 
ATCCCCTCCA GAGCCGGAGC CAACTGGAGC GTGAACTTCC ACAGGATTAA CGAGAATGAG 
AAGTCTCCCA GTCAGAACCG GAAAGCCAAG GACGCCACCT CAGACAACGG CAAAGACGGC 
CTGGCCTACT CTGCCCTGCT CAAGAATGAG CTGCTGGGTG CCGGCATCGA GAAGGTGCAG 
GACCCGCAGA CTGAGGACCG CAGGCTGCAG CCCTCCACGC CTGAGAAGAA GGGTCTGTTC 
ACGTATTCCC TTAGCACCAA GCGCTCCAGC CCCGATGACG GCAACGATGT GTCTCCCTAC 
TCCCTGTCTC CCGTCAGCAA CAAGAGCCAG AAGCTGCTCC GGTCCCCCCG GAAACCCACC 
CGCAAGATCT CCAAGATCCC CTTCAAGGTG CTGGACGCGC CCGAGCTGCA GGACGACTTC 
TACCTCAATC TGGTGGACTG GTCGTCCCTC AATGTGCTCA GCGTGGGGCT AGGCACCTGC 
GTGTACCTGT GGAGTGCCTG TACCAGCCAG GTGACGCGGC TCTGTGACCT CTCAGTGGAA 
GGGGACTCAG TGACCTCCGT GGGCTGGTCT GAGCGGGGGA ACCTGGTGGC GGTGGGCACA 
CACAAGGGCT TCGTGCAGAT CTGGGACGCA GCCGCAGGGA AGAAGCTGTC CATGTTGGAG 
GGCCACACGG CACGCGTCGG GGCGCTGGCC TGGAATGCTG AGCAGCTGTC GTCCGGGAGC 
CGCGACCGCA TGATCCTGCA GAGGGACATC CGCACCCCGC CACTGCAGTC GGAGCGGCGG 
CTGCAGGGCC ACCGGCAGGA GGTGTGCGGG CTCAAGTGGT CCACAGACCA CCAGCTCCTC 
GCCTCGGGGG GCAACGACAA CAAGCTGCTG GTCTGGAATC ACTCGAGCCT GAGCCCCGTG 
CAGCAGTACA CGGAGCACCT GGCGGCCGTG AAGGCCATCG CCTGGTCCCC ACATCAGCAC 
GGGCTGCTGG CCTCGGGGGG CGGCACAGCT GACCGCTGTA TCCGCTTCTG GAACACGCTG 
ACAGGACAAC CACTGCAGTG TATCGACACG GGCTCCCAAG TGTGCAATCT GGCCTGGTCC 
AAGCACGCCA ACGAGCTGGT GAGCACGCAC GGCTACTCAC AGAACCAGAT CCTTGTCTGG 
AAGTACCCCT CCCTGACCCA GGTGGCCAAG CTGACCGGGC ACTCCTACCG CGTGCTGTAC 
CTGGCAATGT CCCCTGATGG GGAGGCCATC GTCACTGGTG CTGGAGACGA GACCCTGAGG 
TTCTGGAACG TCTTTAGCAA AACCCGTTCG ACAAAGGTAA AGTGGGAGTC TGTGTCTGTG 
CTCAACCTCT TCACCAGGAT CCGGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016882352.1
CDS	1863..3449
Translation	MAGSCSGVWRAALVRPSPVDALTLPRAEPCLAMDQDYERRLLRQIVIQNENTMPRVTEMRRTLTPASSPVSSPSKHGDRFIPSRAGANWSVNFHRINENEKSPSQNRKAKDATSDNGKDGLAYSALLKNELLGAGIEKVQDPQTEDRRLQPSTPEKKGLFTYSLSTKRSSPDDGNDVSPYSLSPVSNKSQKLLRSPRKPTRKISKIPFKVLDAPELQDDFYLNLVDWSSLNVLSVGLGTCVYLWSACTSQVTRLCDLSVEGDSVTSVGWSERGNLVAVGTHKGFVQIWDAAAGKKLSMLEGHTARVGALAWNAEQLSSGSRDRMILQRDIRTPPLQSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPVQQYTEHLAAVKAIAWSPHQHGLLASGGGTADRCIRFWNTLTGQPLQCIDTGSQVCNLAWSKHANELVSTHGYSQNQILVWKYPSLTQVAKLTGHSYRVLYLAMSPDGEAIVTGAGDETLRFWNVFSKTRSTKVKWESVSVLNLFTRIR

Target ORF information:

RefSeq Version	XM_017026863.2
Organism	Homo sapiens(human)
Definition	Homo sapiens fizzy and cell division cycle 20 related 1 (FZR1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017026863.2

ORF Insert Sequence:

ATGGCTGGGT CGTGTTCTGG CGTGTGGAGG GCCGCGCTGG TTCGTCCCTC ACCTGTTGAT 
GCGCTAACCT TGCCGCGGGC CGAGCCCTGC CTCGCCATGG ACCAGGACTA TGAGCGGCGC 
CTGCTTCGCC AGATCGTCAT CCAGAATGAG AACACGATGC CACGCGTCAC AGAGATGCGG 
CGGACCCTGA CGCCTGCCAG CTCCCCAGTG TCCTCGCCCA GCAAGCACGG AGACCGCTTC 
ATCCCCTCCA GAGCCGGAGC CAACTGGAGC GTGAACTTCC ACAGGATTAA CGAGAATGAG 
AAGTCTCCCA GTCAGAACCG GAAAGCCAAG GACGCCACCT CAGACAACGG CAAAGACGGC 
CTGGCCTACT CTGCCCTGCT CAAGAATGAG CTGCTGGGTG CCGGCATCGA GAAGGTGCAG 
GACCCGCAGA CTGAGGACCG CAGGCTGCAG CCCTCCACGC CTGAGAAGAA GGGTCTGTTC 
ACGTATTCCC TTAGCACCAA GCGCTCCAGC CCCGATGACG GCAACGATGT GTCTCCCTAC 
TCCCTGTCTC CCGTCAGCAA CAAGAGCCAG AAGCTGCTCC GGTCCCCCCG GAAACCCACC 
CGCAAGATCT CCAAGATCCC CTTCAAGGTG CTGGACGCGC CCGAGCTGCA GGACGACTTC 
TACCTCAATC TGGTGGACTG GTCGTCCCTC AATGTGCTCA GCGTGGGGCT AGGCACCTGC 
GTGTACCTGT GGAGTGCCTG TACCAGCCAG GTGACGCGGC TCTGTGACCT CTCAGTGGAA 
GGGGACTCAG TGACCTCCGT GGGCTGGTCT GAGCGGGGGA ACCTGGTGGC GGTGGGCACA 
CACAAGGGCT TCGTGCAGAT CTGGGACGCA GCCGCAGGGA AGAAGCTGTC CATGTTGGAG 
GGCCACACGG CACGCGTCGG GGCGCTGGCC TGGAATGCTG AGCAGCTGTC GTCCGGGAGC 
CGCGACCGCA TGATCCTGCA GAGGGACATC CGCACCCCGC CACTGCAGTC GGAGCGGCGG 
CTGCAGGGCC ACCGGCAGGA GGTGTGCGGG CTCAAGTGGT CCACAGACCA CCAGCTCCTC 
GCCTCGGGGG GCAACGACAA CAAGCTGCTG GTCTGGAATC ACTCGAGCCT GAGCCCCGTG 
CAGCAGTACA CGGAGCACCT GGCGGCCGTG AAGGCCATCG CCTGGTCCCC ACATCAGCAC 
GGGCTGCTGG CCTCGGGGGG CGGCACAGCT GACCGCTGTA TCCGCTTCTG GAACACGCTG 
ACAGGACAAC CACTGCAGTG TATCGACACG GGCTCCCAAG TGTGCAATCT GGCCTGGTCC 
AAGCACGCCA ACGAGCTGGT GAGCACGCAC GGCTACTCAC AGAACCAGAT CCTTGTCTGG 
AAGTACCCCT CCCTGACCCA GGTGGCCAAG CTGACCGGGC ACTCCTACCG CGTGCTGTAC 
CTGGCAATGT CCCCTGATGG GGAGGCCATC GTCACTGGTG CTGGAGACGA GACCCTGAGG 
TTCTGGAACG TCTTTAGCAA AACCCGTTCG ACAAAGGTAA AGTGGGAGTC TGTGTCTGTG 
CTCAACCTCT TCACCAGGAT CCGGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

A cell based screening approach for identifying protein degradation regulators.
Cell cycle (Georgetown, Tex.)16(10)940-946(2017 May)
Simanski S,Maloof ME,Sato TK,Cavett V,Caldwell Busby J,Ayad NG

The APC/C E3 Ligase Complex Activator FZR1 Restricts BRAF Oncogenic Function.
Cancer discovery7(4)424-441(2017 04)
Wan L,Chen M,Cao J,Dai X,Yin Q,Zhang J,Song SJ,Lu Y,Liu J,Inuzuka H,Katon JM,Berry K,Fung J,Ng C,Liu P,Song MS,Xue L,Bronson RT,Kirschner MW,Cui R,Pandolfi PP,Wei W

Anaphase-Promoting Complex Adaptor FZR1/CDH1 Blocks BRAF Signaling Both by Targeting BRAF for Proteolytic Degradation and by Disrupting BRAF Dimerization.
Cancer discovery7(4)356-358(2017 04)
Zhang C,Bollag G

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FZR1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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