Gene Symbol | PDCD1 |
Entrez Gene ID | 5133 |
Full Name | programmed cell death 1 |
Synonyms | CD279,PD-1,PD1,SLEB2,hPD-1,hPD-l,hSLE1 |
General protein information |
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Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Summary | This gene encodes a cell surface membrane protein of the immunoglobulin superfamily. This protein is expressed in pro-B-cells and is thought to play a role in their differentiation. In mice, expression of this gene is induced in the thymus when anti-CD3 antibodies are injected and large numbers of thymocytes undergo apoptosis. Mice deficient for this gene bred on a BALB/c background developed dilated cardiomyopathy and died from congestive heart failure. These studies suggest that this gene product may also be important in T cell function and contribute to the prevention of autoimmune diseases. [provided by RefSeq, Jul 2008]. |
Disorder MIM: | |
Disorder Html: | {Systemic lupus erythematosus, susceptibility to, 2}, 605218 (3); {Multiple sclerosis, disease progression, modifier of}, 126200 (3) |