PDC cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	PDC
Entrez Gene ID	5132
Full Name	phosducin
Synonyms	MEKA,PHD,PhLOP,PhLP
General protein information	Preferred Names phosducin Names phosducin 33 kDa phototransducing protein G beta gamma binding protein phosducin-like orphan protein
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1q31.1
Summary	This gene encodes a phosphoprotein, which is located in the outer and inner segments of the rod cells in the retina. This protein may participate in the regulation of visual phototransduction or in the integration of photoreceptor metabolism. It modulates the phototransduction cascade by interacting with the beta and gamma subunits of the retinal G-protein transducin. This gene is a potential candidate gene for retinitis pigmentosa and Usher syndrome type II. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008].
Disorder MIM:	171490

mRNA and Protein(s)

mRNA	Protein	Name
XM_011509603.2	XP_011507905.1	phosducin isoform X1
NM_002597.4	NP_002588.3	phosducin isoform a
NM_002597.5	NP_002588.3	phosducin isoform a
NM_022576.3	NP_072098.1	phosducin isoform b

Pathways from BioSystems

Homologies

Xenopus tropicalis (tropical clawed frog)	pdc	XP_002933816.2
Homo sapiens (human)	PDC	NP_002588.3
Canis lupus familiaris (dog)	PDC	NP_001003076.1
Bos taurus (cattle)	PDC	NP_001159999.1
Mus musculus (house mouse)	Pdc	NP_001153202.1
Pan troglodytes (chimpanzee)	PDC	XP_524997.3
Rattus norvegicus (Norway rat)	Pdc	NP_037004.1
Gallus gallus (chicken)	PDC	XP_004943359.1
Danio rerio (zebrafish)	pdcb	NP_001020635.2
	PDC	XP_001107723.2
Danio rerio (zebrafish)	pdca	XP_682823.4

Gene Ontology
Bibliography

Related articles in PubMed

Phosducin regulates secretory activity in TT line of thyroid parafollicular C cells.
Piotrowska U, Adler G, Kozicki I
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme47(2)114-8(2015 Feb)

Phosducin rs12402521 polymorphism predicts development of hypertension in young subjects with overweight or obesity.
Palatini P, Ceolotto G, Ragazzo F, Mos L, Santonastaso M, Zanata G, Saladini F, Casiglia E,
Nutrition, metabolism, and cardiovascular diseases : NMCD23(4)323-9(2013 Apr)

The identification of phosducin as a novel candidate gene for hypertension and its role in sympathetic activation.
Broeckel U, Stoll M, Hein L
Current opinion in nephrology and hypertension20(2)118-24(2011 Mar)

Phosducin and monomeric ?-actin have common epitope recognized by anti-phosducin antibodies.
Piotrowska U, Adler G
Immunology letters134(1)62-8(2010 Nov)

Phosducin influences sympathetic activity and prevents stress-induced hypertension in humans and mice.
Beetz N, Harrison MD, Brede M, Zong X, Urbanski MJ, Sietmann A, Kaufling J, Lorkowski S, Barrot M, Seeliger MW, Vieira-Coelho MA, Hamet P, Gaudet D, Seda O, Tremblay J, Kotchen TA, Kaldunski M, N?sing R, Szabo B, Jacob HJ, Cowley AW Jr, Biel M, Stoll M, Lohse MJ, Broeckel U, Hein L
The Journal of clinical investigation119(12)3597-3612(2009 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Phosducin regulates secretory activity in TT line of thyroid parafollicular C cells.
Title: Phosducin regulates secretory activity in TT line of thyroid parafollicular C cells.

Data suggest that phosducin rs12402521 polymorphism is an important genetic predictor of obesity-related hypertension.
Title: Phosducin rs12402521 polymorphism predicts development of hypertension in young subjects with overweight or obesity.

identification of Pdc as a gene for stress-induced hypertension offers new insights into the relationship between sympathetic nervous system activation, blood pressure regulation and genetic factors
Title: The identification of phosducin as a novel candidate gene for hypertension and its role in sympathetic activation.

Data suggest that the existence of a common epitope on the molecules of phosducin and beta-actin may reflect a topological similarity of a small region of their surfaces.
Title: Phosducin and monomeric ?-actin have common epitope recognized by anti-phosducin antibodies.

Candidate gene-based association studies in 2 different populations revealed several SNPs in the PDC gene to be associated with stress-dependent blood pressure phenotypes.
Title: Phosducin influences sympathetic activity and prevents stress-induced hypertension in humans and mice.

The following PDC gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PDC cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu32233	NM_022576.3 Latest version!	Homo sapiens phosducin (PDC), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu18912	NM_002597.5 Latest version!	Homo sapiens phosducin (PDC), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
OHu18912	XM_011509603.2 Latest version!	Homo sapiens phosducin (PDC), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
View Old Accession Versions >>
OHu18912	NM_002597.4	Homo sapiens phosducin (PDC), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

PDC ( NM_022576.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_072098.1 Homo sapiens phosducin (PDC), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu32233
Clone ID Related Accession (Same CDS sequence)	NM_022576.3
Accession Version	NM_022576.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 585bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-05
Organism	Homo sapiens(human)
Product	phosducin isoform b
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF076464.1 and BM674109.1. On Apr 29, 2011 this sequence version replaced NM_022576.2. Transcript Variant: This variant (2), also known as PHLOP1, has an alternate 5' sequence, resulting in a downstream AUG start codon, compared to variant 1. The resulting isoform (b) is shorter at the N-terminus, compared to isoform a. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF076464.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2151119 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTCTTCTC CTCAGAGTAG GAATGGCAAA GATTCAAAGG AACGAGTCAG CAGAAAGATG 
AGCATTCAAG AATATGAACT AATCCATAAA GAGAAAGAGG ATGAAAACTG CCTTCGTAAA 
TACCGTAGAC AGTGTATGCA GGATATGCAC CAGAAGCTGA GTTTTGGGCC TAGATATGGG 
TTTGTGTATG AGCTGGAAAC TGGAAAGCAA TTCCTAGAAA CAATTGAAAA GGAACTGAAG 
ATCACCACAA TTGTTGTTCA CATTTATGAA GATGGTATTA AGGGTTGTGA TGCTCTAAAC 
AGTAGTTTAA CATGCCTTGC AGCAGAATAC CCTATAGTTA AGTTTTGTAA AATAAAAGCT 
TCGAATACAG GTGCTGGGGA CCGCTTTTCC TTAGATGTAC TTCCTACACT GCTCATCTAT 
AAAGGTGGGG AACTCATAAG CAATTTTATT AGTGTTGCTG AACAGTTTGC TGAAGAATTT 
TTTGCTGGGG ATGTGGAGTC TTTCCTAAAT GAATATGGGT TACTACCTGA AAGAGAGGTA 
CATGTCCTAG AGCATACCAA AATAGAAGAA GAAGATGTTG AATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_072098.1
CDS	193..777
Translation	MSSPQSRNGKDSKERVSRKMSIQEYELIHKEKEDENCLRKYRRQCMQDMHQKLSFGPRYGFVYELETGKQFLETIEKELKITTIVVHIYEDGIKGCDALNSSLTCLAAEYPIVKFCKIKASNTGAGDRFSLDVLPTLLIYKGGELISNFISVAEQFAEEFFAGDVESFLNEYGLLPEREVHVLEHTKIEEEDVE

Target ORF information:

RefSeq Version	NM_022576.3
Organism	Homo sapiens(human)
Definition	Homo sapiens phosducin (PDC), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_022576.3

ORF Insert Sequence:

ATGTCTTCTC CTCAGAGTAG GAATGGCAAA GATTCAAAGG AACGAGTCAG CAGAAAGATG 
AGCATTCAAG AATATGAACT AATCCATAAA GAGAAAGAGG ATGAAAACTG CCTTCGTAAA 
TACCGTAGAC AGTGTATGCA GGATATGCAC CAGAAGCTGA GTTTTGGGCC TAGATATGGG 
TTTGTGTATG AGCTGGAAAC TGGAAAGCAA TTCCTAGAAA CAATTGAAAA GGAACTGAAG 
ATCACCACAA TTGTTGTTCA CATTTATGAA GATGGTATTA AGGGTTGTGA TGCTCTAAAC 
AGTAGTTTAA CATGCCTTGC AGCAGAATAC CCTATAGTTA AGTTTTGTAA AATAAAAGCT 
TCGAATACAG GTGCTGGGGA CCGCTTTTCC TTAGATGTAC TTCCTACACT GCTCATCTAT 
AAAGGTGGGG AACTCATAAG CAATTTTATT AGTGTTGCTG AACAGTTTGC TGAAGAATTT 
TTTGCTGGGG ATGTGGAGTC TTTCCTAAAT GAATATGGGT TACTACCTGA AAGAGAGGTA 
CATGTCCTAG AGCATACCAA AATAGAAGAA GAAGATGTTG AATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PDC ( NM_002597.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_002588.3 Homo sapiens phosducin (PDC), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu18912
Clone ID Related Accession (Same CDS sequence)	XM_011509603.2 , NM_002597.4 , NM_002597.5
Accession Version	NM_002597.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 741bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-22
Organism	Homo sapiens(human)
Product	phosducin isoform a
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from EL945964.1, BC093839.1, BM715757.1 and BM674109.1. This sequence is a reference standard in the RefSeqGene project. On Jun 12, 2012 this sequence version replaced NM_002597.3. Transcript Variant: This variant (1), also known as PHD, represents the longer transcript, and encodes the longer isoform (a). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: M33478.1, AL712565.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA2149398, SAMEA2151119 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAAGAAG CCAAAAGCCA AAGTTTGGAG GAAGACTTTG AAGGACAGGC CACACATACA 
GGACCCAAAG GAGTAATAAA TGATTGGAGA AAGTTTAAAT TAGAGAGTCA AGACAGTGAT 
TCAATTCCAC CTAGCAAGAA GGAGATTCTC AGGCAAATGT CTTCTCCTCA GAGTAGGAAT 
GGCAAAGATT CAAAGGAACG AGTCAGCAGA AAGATGAGCA TTCAAGAATA TGAACTAATC 
CATAAAGAGA AAGAGGATGA AAACTGCCTT CGTAAATACC GTAGACAGTG TATGCAGGAT 
ATGCACCAGA AGCTGAGTTT TGGGCCTAGA TATGGGTTTG TGTATGAGCT GGAAACTGGA 
AAGCAATTCC TAGAAACAAT TGAAAAGGAA CTGAAGATCA CCACAATTGT TGTTCACATT 
TATGAAGATG GTATTAAGGG TTGTGATGCT CTAAACAGTA GTTTAACATG CCTTGCAGCA 
GAATACCCTA TAGTTAAGTT TTGTAAAATA AAAGCTTCGA ATACAGGTGC TGGGGACCGC 
TTTTCCTTAG ATGTACTTCC TACACTGCTC ATCTATAAAG GTGGGGAACT CATAAGCAAT 
TTTATTAGTG TTGCTGAACA GTTTGCTGAA GAATTTTTTG CTGGGGATGT GGAGTCTTTC 
CTAAATGAAT ATGGGTTACT ACCTGAAAGA GAGGTACATG TCCTAGAGCA TACCAAAATA 
GAAGAAGAAG ATGTTGAATG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002588.3
CDS	75..815
Translation	MEEAKSQSLEEDFEGQATHTGPKGVINDWRKFKLESQDSDSIPPSKKEILRQMSSPQSRNGKDSKERVSRKMSIQEYELIHKEKEDENCLRKYRRQCMQDMHQKLSFGPRYGFVYELETGKQFLETIEKELKITTIVVHIYEDGIKGCDALNSSLTCLAAEYPIVKFCKIKASNTGAGDRFSLDVLPTLLIYKGGELISNFISVAEQFAEEFFAGDVESFLNEYGLLPEREVHVLEHTKIEEEDVE

Target ORF information:

RefSeq Version	NM_002597.4
Organism	Homo sapiens(human)
Definition	Homo sapiens phosducin (PDC), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002597.4

ORF Insert Sequence:

ATGGAAGAAG CCAAAAGCCA AAGTTTGGAG GAAGACTTTG AAGGACAGGC CACACATACA 
GGACCCAAAG GAGTAATAAA TGATTGGAGA AAGTTTAAAT TAGAGAGTCA AGACAGTGAT 
TCAATTCCAC CTAGCAAGAA GGAGATTCTC AGGCAAATGT CTTCTCCTCA GAGTAGGAAT 
GGCAAAGATT CAAAGGAACG AGTCAGCAGA AAGATGAGCA TTCAAGAATA TGAACTAATC 
CATAAAGAGA AAGAGGATGA AAACTGCCTT CGTAAATACC GTAGACAGTG TATGCAGGAT 
ATGCACCAGA AGCTGAGTTT TGGGCCTAGA TATGGGTTTG TGTATGAGCT GGAAACTGGA 
AAGCAATTCC TAGAAACAAT TGAAAAGGAA CTGAAGATCA CCACAATTGT TGTTCACATT 
TATGAAGATG GTATTAAGGG TTGTGATGCT CTAAACAGTA GTTTAACATG CCTTGCAGCA 
GAATACCCTA TAGTTAAGTT TTGTAAAATA AAAGCTTCGA ATACAGGTGC TGGGGACCGC 
TTTTCCTTAG ATGTACTTCC TACACTGCTC ATCTATAAAG GTGGGGAACT CATAAGCAAT 
TTTATTAGTG TTGCTGAACA GTTTGCTGAA GAATTTTTTG CTGGGGATGT GGAGTCTTTC 
CTAAATGAAT ATGGGTTACT ACCTGAAAGA GAGGTACATG TCCTAGAGCA TACCAAAATA 
GAAGAAGAAG ATGTTGAATG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PDC ( NM_002597.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_002588.3 Homo sapiens phosducin (PDC), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu18912
Clone ID Related Accession (Same CDS sequence)	XM_011509603.2 , NM_002597.4 , NM_002597.5
Accession Version	NM_002597.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 741bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-25
Organism	Homo sapiens(human)
Product	phosducin isoform a
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL663036.5, EL945964.1, BC093839.1, BM715757.1 and BM674109.1. This sequence is a reference standard in the RefSeqGene project. On May 17, 2019 this sequence version replaced NM_002597.4. Transcript Variant: This variant (1), also known as PHD, represents the longer transcript, and encodes the longer isoform (a). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: M33478.1, AL712565.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA2149398, SAMEA2151119 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000391997.3/ ENSP00000375855.2 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGAAGAAG CCAAAAGCCA AAGTTTGGAG GAAGACTTTG AAGGACAGGC CACACATACA 
GGACCCAAAG GAGTAATAAA TGATTGGAGA AAGTTTAAAT TAGAGAGTCA AGACAGTGAT 
TCAATTCCAC CTAGCAAGAA GGAGATTCTC AGGCAAATGT CTTCTCCTCA GAGTAGGAAT 
GGCAAAGATT CAAAGGAACG AGTCAGCAGA AAGATGAGCA TTCAAGAATA TGAACTAATC 
CATAAAGAGA AAGAGGATGA AAACTGCCTT CGTAAATACC GTAGACAGTG TATGCAGGAT 
ATGCACCAGA AGCTGAGTTT TGGGCCTAGA TATGGGTTTG TGTATGAGCT GGAAACTGGA 
AAGCAATTCC TAGAAACAAT TGAAAAGGAA CTGAAGATCA CCACAATTGT TGTTCACATT 
TATGAAGATG GTATTAAGGG TTGTGATGCT CTAAACAGTA GTTTAACATG CCTTGCAGCA 
GAATACCCTA TAGTTAAGTT TTGTAAAATA AAAGCTTCGA ATACAGGTGC TGGGGACCGC 
TTTTCCTTAG ATGTACTTCC TACACTGCTC ATCTATAAAG GTGGGGAACT CATAAGCAAT 
TTTATTAGTG TTGCTGAACA GTTTGCTGAA GAATTTTTTG CTGGGGATGT GGAGTCTTTC 
CTAAATGAAT ATGGGTTACT ACCTGAAAGA GAGGTACATG TCCTAGAGCA TACCAAAATA 
GAAGAAGAAG ATGTTGAATG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002588.3
CDS	81..821
Translation	MEEAKSQSLEEDFEGQATHTGPKGVINDWRKFKLESQDSDSIPPSKKEILRQMSSPQSRNGKDSKERVSRKMSIQEYELIHKEKEDENCLRKYRRQCMQDMHQKLSFGPRYGFVYELETGKQFLETIEKELKITTIVVHIYEDGIKGCDALNSSLTCLAAEYPIVKFCKIKASNTGAGDRFSLDVLPTLLIYKGGELISNFISVAEQFAEEFFAGDVESFLNEYGLLPEREVHVLEHTKIEEEDVE

Target ORF information:

RefSeq Version	NM_002597.5
Organism	Homo sapiens(human)
Definition	Homo sapiens phosducin (PDC), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002597.5

ORF Insert Sequence:

ATGGAAGAAG CCAAAAGCCA AAGTTTGGAG GAAGACTTTG AAGGACAGGC CACACATACA 
GGACCCAAAG GAGTAATAAA TGATTGGAGA AAGTTTAAAT TAGAGAGTCA AGACAGTGAT 
TCAATTCCAC CTAGCAAGAA GGAGATTCTC AGGCAAATGT CTTCTCCTCA GAGTAGGAAT 
GGCAAAGATT CAAAGGAACG AGTCAGCAGA AAGATGAGCA TTCAAGAATA TGAACTAATC 
CATAAAGAGA AAGAGGATGA AAACTGCCTT CGTAAATACC GTAGACAGTG TATGCAGGAT 
ATGCACCAGA AGCTGAGTTT TGGGCCTAGA TATGGGTTTG TGTATGAGCT GGAAACTGGA 
AAGCAATTCC TAGAAACAAT TGAAAAGGAA CTGAAGATCA CCACAATTGT TGTTCACATT 
TATGAAGATG GTATTAAGGG TTGTGATGCT CTAAACAGTA GTTTAACATG CCTTGCAGCA 
GAATACCCTA TAGTTAAGTT TTGTAAAATA AAAGCTTCGA ATACAGGTGC TGGGGACCGC 
TTTTCCTTAG ATGTACTTCC TACACTGCTC ATCTATAAAG GTGGGGAACT CATAAGCAAT 
TTTATTAGTG TTGCTGAACA GTTTGCTGAA GAATTTTTTG CTGGGGATGT GGAGTCTTTC 
CTAAATGAAT ATGGGTTACT ACCTGAAAGA GAGGTACATG TCCTAGAGCA TACCAAAATA 
GAAGAAGAAG ATGTTGAATG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PDC ( XM_011509603.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_011507905.1 Homo sapiens phosducin (PDC), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu18912
Clone ID Related Accession (Same CDS sequence)	XM_011509603.2 , NM_002597.4 , NM_002597.5
Accession Version	XM_011509603.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 741bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	phosducin isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000001.11) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011509603.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGAAGAAG CCAAAAGCCA AAGTTTGGAG GAAGACTTTG AAGGACAGGC CACACATACA 
GGACCCAAAG GAGTAATAAA TGATTGGAGA AAGTTTAAAT TAGAGAGTCA AGACAGTGAT 
TCAATTCCAC CTAGCAAGAA GGAGATTCTC AGGCAAATGT CTTCTCCTCA GAGTAGGAAT 
GGCAAAGATT CAAAGGAACG AGTCAGCAGA AAGATGAGCA TTCAAGAATA TGAACTAATC 
CATAAAGAGA AAGAGGATGA AAACTGCCTT CGTAAATACC GTAGACAGTG TATGCAGGAT 
ATGCACCAGA AGCTGAGTTT TGGGCCTAGA TATGGGTTTG TGTATGAGCT GGAAACTGGA 
AAGCAATTCC TAGAAACAAT TGAAAAGGAA CTGAAGATCA CCACAATTGT TGTTCACATT 
TATGAAGATG GTATTAAGGG TTGTGATGCT CTAAACAGTA GTTTAACATG CCTTGCAGCA 
GAATACCCTA TAGTTAAGTT TTGTAAAATA AAAGCTTCGA ATACAGGTGC TGGGGACCGC 
TTTTCCTTAG ATGTACTTCC TACACTGCTC ATCTATAAAG GTGGGGAACT CATAAGCAAT 
TTTATTAGTG TTGCTGAACA GTTTGCTGAA GAATTTTTTG CTGGGGATGT GGAGTCTTTC 
CTAAATGAAT ATGGGTTACT ACCTGAAAGA GAGGTACATG TCCTAGAGCA TACCAAAATA 
GAAGAAGAAG ATGTTGAATG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011507905.1
CDS	1093..1833
Translation	MEEAKSQSLEEDFEGQATHTGPKGVINDWRKFKLESQDSDSIPPSKKEILRQMSSPQSRNGKDSKERVSRKMSIQEYELIHKEKEDENCLRKYRRQCMQDMHQKLSFGPRYGFVYELETGKQFLETIEKELKITTIVVHIYEDGIKGCDALNSSLTCLAAEYPIVKFCKIKASNTGAGDRFSLDVLPTLLIYKGGELISNFISVAEQFAEEFFAGDVESFLNEYGLLPEREVHVLEHTKIEEEDVE

Target ORF information:

RefSeq Version	XM_011509603.2
Organism	Homo sapiens(human)
Definition	Homo sapiens phosducin (PDC), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011509603.2

ORF Insert Sequence:

ATGGAAGAAG CCAAAAGCCA AAGTTTGGAG GAAGACTTTG AAGGACAGGC CACACATACA 
GGACCCAAAG GAGTAATAAA TGATTGGAGA AAGTTTAAAT TAGAGAGTCA AGACAGTGAT 
TCAATTCCAC CTAGCAAGAA GGAGATTCTC AGGCAAATGT CTTCTCCTCA GAGTAGGAAT 
GGCAAAGATT CAAAGGAACG AGTCAGCAGA AAGATGAGCA TTCAAGAATA TGAACTAATC 
CATAAAGAGA AAGAGGATGA AAACTGCCTT CGTAAATACC GTAGACAGTG TATGCAGGAT 
ATGCACCAGA AGCTGAGTTT TGGGCCTAGA TATGGGTTTG TGTATGAGCT GGAAACTGGA 
AAGCAATTCC TAGAAACAAT TGAAAAGGAA CTGAAGATCA CCACAATTGT TGTTCACATT 
TATGAAGATG GTATTAAGGG TTGTGATGCT CTAAACAGTA GTTTAACATG CCTTGCAGCA 
GAATACCCTA TAGTTAAGTT TTGTAAAATA AAAGCTTCGA ATACAGGTGC TGGGGACCGC 
TTTTCCTTAG ATGTACTTCC TACACTGCTC ATCTATAAAG GTGGGGAACT CATAAGCAAT 
TTTATTAGTG TTGCTGAACA GTTTGCTGAA GAATTTTTTG CTGGGGATGT GGAGTCTTTC 
CTAAATGAAT ATGGGTTACT ACCTGAAAGA GAGGTACATG TCCTAGAGCA TACCAAAATA 
GAAGAAGAAG ATGTTGAATG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Phosducin regulates secretory activity in TT line of thyroid parafollicular C cells.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme47(2)114-8(2015 Feb)
Piotrowska U,Adler G,Kozicki I

Phosducin rs12402521 polymorphism predicts development of hypertension in young subjects with overweight or obesity.
Nutrition, metabolism, and cardiovascular diseases : NMCD23(4)323-9(2013 Apr)
Palatini P,Ceolotto G,Ragazzo F,Mos L,Santonastaso M,Zanata G,Saladini F,Casiglia E,

The identification of phosducin as a novel candidate gene for hypertension and its role in sympathetic activation.
Current opinion in nephrology and hypertension20(2)118-24(2011 Mar)
Broeckel U,Stoll M,Hein L

Phosducin and monomeric ?-actin have common epitope recognized by anti-phosducin antibodies.
Immunology letters134(1)62-8(2010 Nov)
Piotrowska U,Adler G

Phosducin influences sympathetic activity and prevents stress-induced hypertension in humans and mice.
The Journal of clinical investigation119(12)3597-3612(2009 Dec)
Beetz N,Harrison MD,Brede M,Zong X,Urbanski MJ,Sietmann A,Kaufling J,Lorkowski S,Barrot M,Seeliger MW,Vieira-Coelho MA,Hamet P,Gaudet D,Seda O,Tremblay J,Kotchen TA,Kaldunski M,N?sing R,Szabo B,Jacob HJ,Cowley AW Jr,Biel M,Stoll M,Lohse MJ,Broeckel U,Hein L

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PDC cDNA ORF clone, Homo sapiens(human)

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Clones

gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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