TIMMDC1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	TIMMDC1
Entrez Gene ID	51300
Full Name	translocase of inner mitochondrial membrane domain containing 1
Synonyms	C3orf1
General protein information	Preferred Names translocase of inner mitochondrial membrane domain containing 1 Names complex I assembly factor TIMMDC1, mitochondrial M5-14 protein TIMM domain containing-protein 1 translocase of inner mitochondrial membrane domain-containing protein 1 transmembrane protein C3orf1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 3 Map Location: 3q13.33
Disorder MIM:	615534
Disorder Html:	Mitochondrial complex I deficiency, 252010 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_016589.4	NP_057673.2	complex I assembly factor TIMMDC1, mitochondrial precursor
NM_016589.3	NP_057673.2	complex I assembly factor TIMMDC1, mitochondrial precursor
XM_017006556.1	XP_016862045.1	complex I assembly factor TIMMDC1, mitochondrial isoform X1

Pathways from BioSystems

Homologies

Homo sapiens (human)	TIMMDC1	NP_057673.2
Danio rerio (zebrafish)	timmdc1	NP_001017828.1
Rattus norvegicus (Norway rat)	Timmdc1	NP_001007677.1
Gallus gallus (chicken)	TIMMDC1	NP_001244219.1
Drosophila melanogaster (fruit fly)	140up	NP_001262561.1
Pan troglodytes (chimpanzee)	TIMMDC1	NP_001230840.1
	C3orf1	XP_001109560.2
Bos taurus (cattle)	TIMMDC1	NP_001073704.1
Mus musculus (house mouse)	Timmdc1	NP_077235.2
Canis lupus familiaris (dog)	TIMMDC1	XP_545116.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP001426	XP_321704.5

Gene Ontology
Bibliography

Related articles in PubMed

Depletion of C3orf1/TIMMDC1 inhibits migration and proliferation in 95D lung carcinoma cells.
Wu H, Wang W, Xu H
International journal of molecular sciences15(11)20555-71(2014 Nov)

TIMMDC1/C3orf1 functions as a membrane-embedded mitochondrial complex I assembly factor through association with the MCIA complex.
Guarani V, Paulo J, Zhai B, Huttlin EL, Gygi SP, Harper JW
Molecular and cellular biology34(5)847-61(2014 Mar)

Assembly factors for the membrane arm of human complex I.
Andrews B, Carroll J, Ding S, Fearnley IM, Walker JE
Proceedings of the National Academy of Sciences of the United States of America110(47)18934-9(2013 Nov)

Genome-wide association study identifies TNFSF15 and POU2AF1 as susceptibility loci for primary biliary cirrhosis in the Japanese population.
Nakamura M, Nishida N, Kawashima M, Aiba Y, Tanaka A, Yasunami M, Nakamura H, Komori A, Nakamuta M, Zeniya M, Hashimoto E, Ohira H, Yamamoto K, Onji M, Kaneko S, Honda M, Yamagiwa S, Nakao K, Ichida T, Takikawa H, Seike M, Umemura T, Ueno Y, Sakisaka S, Kikuchi K, Ebinuma H, Yamashiki N, Tamura S, Sugawara Y, Mori A, Yagi S, Shirabe K, Taketomi A, Arai K, Monoe K, Ichikawa T, Taniai M, Miyake Y, Kumagi T, Abe M, Yoshizawa K, Joshita S, Shimoda S, Honda K, Takahashi H, Hirano K, Takeyama Y, Harada K, Migita K, Ito M, Yatsuhashi H, Fukushima N, Ota H, Komatsu T, Saoshiro T, Ishida J, Kouno H, Kouno H, Yagura M, Kobayashi M, Muro T, Masaki N, Hirata K, Watanabe Y, Nakamura Y, Shimada M, Hirashima N, Komeda T, Sugi K, Koga M, Ario K, Takesaki E, Maehara Y, Uemoto S, Kokudo N, Tsubouchi H, Mizokami M, Nakanuma Y, Tokunaga K, Ishibashi H
American journal of human genetics91(4)721-8(2012 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Cell-cycle arrest genes such as CCNG2 and PTEN as well as genes involved in cell migration inhibition, such as TIMP3 and COL3A1, were upregulated after C3orf1 depletion in 95D cells.
Title: Depletion of C3orf1/TIMMDC1 inhibits migration and proliferation in 95D lung carcinoma cells.

Quantitative proteomics demonstrated a role for TIMMDC1 in assembly of membrane-embedded and soluble arms of the complex.
Title: TIMMDC1/C3orf1 functions as a membrane-embedded mitochondrial complex I assembly factor through association with the MCIA complex.

Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Single nucleotide polymorphisms of matrix metalloproteinase 9 (MMP9) and tumor protein 73 (TP73) interact with Epstein-Barr virus in chronic lymphocytic leukemia: results from the European case-control study EpiLymph.

Observational study of gene-disease association. (HuGE Navigator)
Title: Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.

Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
Title: Genome-wide conditional search for epistatic disease-predisposing variants in human association studies.

The following TIMMDC1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TIMMDC1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu17361	NM_016589.4 Latest version!	Homo sapiens translocase of inner mitochondrial membrane domain containing 1 (TIMMDC1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$154.50-$216.30 $309.00
OHu94259	XM_017006556.1 Latest version!	Homo sapiens translocase of inner mitochondrial membrane domain containing 1 (TIMMDC1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
View Old Accession Versions >>
OHu17361	NM_016589.3	Homo sapiens translocase of inner mitochondrial membrane domain containing 1 (TIMMDC1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$154.50-$216.30 $309.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

TIMMDC1 ( NM_016589.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_057673.2 Homo sapiens translocase of inner mitochondrial membrane domain containing 1 (TIMMDC1), mRNA.

Price & Availability↑

CloneID	OHu17361
Clone ID Related Accession (Same CDS sequence)	NM_016589.4 , NM_016589.3
Accession Version	NM_016589.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 858bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-25
Organism	Homo sapiens(human)
Product	complex I assembly factor TIMMDC1, mitochondrial precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BG705703.1, AF139077.1, CB105366.1 and AC073352.22. On May 17, 2019 this sequence version replaced NM_016589.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR3476690.163677.1, SRR5189655.173571.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta MANE Ensembl match :: ENST00000494664.6/ ENSP00000418803.1 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END##

ATGGAGGTGC CGCCACCGGC ACCGCGGAGC TTTCTCTGTA GAGCATTGTG CCTATTTCCC 
CGAGTCTTTG CTGCCGAAGC TGTGACTGCC GATTCGGAAG TCCTTGAGGA GCGTCAGAAG 
CGGCTTCCCT ACGTCCCAGA GCCCTATTAC CCGGAATCTG GATGGGACCG CCTCCGGGAG 
CTGTTTGGCA AAGATGAACA GCAGAGAATT TCAAAGGACC TTGCTAATAT CTGTAAGACG 
GCAGCTACAG CAGGCATCAT TGGCTGGGTG TATGGGGGAA TACCAGCTTT TATTCATGCT 
AAACAACAAT ACATTGAGCA GAGCCAGGCA GAAATTTATC ATAACCGGTT TGATGCTGTG 
CAATCTGCAC ATCGTGCTGC CACACGAGGC TTCATTCGTT ATGGCTGGCG CTGGGGTTGG 
AGAACTGCAG TGTTTGTGAC TATATTCAAC ACAGTGAACA CTAGTCTGAA TGTATACCGA 
AATAAAGATG CCTTAAGCCA TTTTGTAATT GCAGGAGCTG TCACGGGAAG TCTTTTTAGG 
ATAAACGTAG GCCTGCGTGG CCTGGTGGCT GGTGGCATAA TTGGAGCCTT GCTGGGCACT 
CCTGTAGGAG GCCTGCTGAT GGCATTTCAG AAGTACTCTG GTGAGACTGT TCAGGAAAGA 
AAACAGAAGG ATCGAAAGGC ACTCCATGAG CTAAAACTGG AAGAGTGGAA AGGCAGACTA 
CAAGTTACTG AGCACCTCCC TGAGAAAATT GAAAGTAGTT TACAGGAAGA TGAACCTGAG 
AATGATGCTA AGAAAATTGA AGCACTGCTA AACCTTCCTA GAAACCCTTC AGTAATAGAT 
AAACAAGACA AGGACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_057673.2
CDS	188..1045
Translation	MEVPPPAPRSFLCRALCLFPRVFAAEAVTADSEVLEERQKRLPYVPEPYYPESGWDRLRELFGKDEQQRISKDLANICKTAATAGIIGWVYGGIPAFIHAKQQYIEQSQAEIYHNRFDAVQSAHRAATRGFIRYGWRWGWRTAVFVTIFNTVNTSLNVYRNKDALSHFVIAGAVTGSLFRINVGLRGLVAGGIIGALLGTPVGGLLMAFQKYSGETVQERKQKDRKALHELKLEEWKGRLQVTEHLPEKIESSLQEDEPENDAKKIEALLNLPRNPSVIDKQDKD

Target ORF information:

RefSeq Version	NM_016589.4
Organism	Homo sapiens(human)
Definition	Homo sapiens translocase of inner mitochondrial membrane domain containing 1 (TIMMDC1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_016589.4

ORF Insert Sequence:

ATGGAGGTGC CGCCACCGGC ACCGCGGAGC TTTCTCTGTA GAGCATTGTG CCTATTTCCC 
CGAGTCTTTG CTGCCGAAGC TGTGACTGCC GATTCGGAAG TCCTTGAGGA GCGTCAGAAG 
CGGCTTCCCT ACGTCCCAGA GCCCTATTAC CCGGAATCTG GATGGGACCG CCTCCGGGAG 
CTGTTTGGCA AAGATGAACA GCAGAGAATT TCAAAGGACC TTGCTAATAT CTGTAAGACG 
GCAGCTACAG CAGGCATCAT TGGCTGGGTG TATGGGGGAA TACCAGCTTT TATTCATGCT 
AAACAACAAT ACATTGAGCA GAGCCAGGCA GAAATTTATC ATAACCGGTT TGATGCTGTG 
CAATCTGCAC ATCGTGCTGC CACACGAGGC TTCATTCGTT ATGGCTGGCG CTGGGGTTGG 
AGAACTGCAG TGTTTGTGAC TATATTCAAC ACAGTGAACA CTAGTCTGAA TGTATACCGA 
AATAAAGATG CCTTAAGCCA TTTTGTAATT GCAGGAGCTG TCACGGGAAG TCTTTTTAGG 
ATAAACGTAG GCCTGCGTGG CCTGGTGGCT GGTGGCATAA TTGGAGCCTT GCTGGGCACT 
CCTGTAGGAG GCCTGCTGAT GGCATTTCAG AAGTACTCTG GTGAGACTGT TCAGGAAAGA 
AAACAGAAGG ATCGAAAGGC ACTCCATGAG CTAAAACTGG AAGAGTGGAA AGGCAGACTA 
CAAGTTACTG AGCACCTCCC TGAGAAAATT GAAAGTAGTT TACAGGAAGA TGAACCTGAG 
AATGATGCTA AGAAAATTGA AGCACTGCTA AACCTTCCTA GAAACCCTTC AGTAATAGAT 
AAACAAGACA AGGACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TIMMDC1 ( NM_016589.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_057673.2 Homo sapiens translocase of inner mitochondrial membrane domain containing 1 (TIMMDC1), mRNA.

Price & Availability↑

CloneID	OHu17361
Clone ID Related Accession (Same CDS sequence)	NM_016589.4 , NM_016589.3
Accession Version	NM_016589.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 858bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-16
Organism	Homo sapiens(human)
Product	complex I assembly factor TIMMDC1, mitochondrial precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BG705703.1, AF139077.1 and CB105366.1. On Sep 16, 2005 this sequence version replaced NM_016589.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803611.449137.1, SRR1660807.310929.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END##

ATGGAGGTGC CGCCACCGGC ACCGCGGAGC TTTCTCTGTA GAGCATTGTG CCTATTTCCC 
CGAGTCTTTG CTGCCGAAGC TGTGACTGCC GATTCGGAAG TCCTTGAGGA GCGTCAGAAG 
CGGCTTCCCT ACGTCCCAGA GCCCTATTAC CCGGAATCTG GATGGGACCG CCTCCGGGAG 
CTGTTTGGCA AAGATGAACA GCAGAGAATT TCAAAGGACC TTGCTAATAT CTGTAAGACG 
GCAGCTACAG CAGGCATCAT TGGCTGGGTG TATGGGGGAA TACCAGCTTT TATTCATGCT 
AAACAACAAT ACATTGAGCA GAGCCAGGCA GAAATTTATC ATAACCGGTT TGATGCTGTG 
CAATCTGCAC ATCGTGCTGC CACACGAGGC TTCATTCGTT ATGGCTGGCG CTGGGGTTGG 
AGAACTGCAG TGTTTGTGAC TATATTCAAC ACAGTGAACA CTAGTCTGAA TGTATACCGA 
AATAAAGATG CCTTAAGCCA TTTTGTAATT GCAGGAGCTG TCACGGGAAG TCTTTTTAGG 
ATAAACGTAG GCCTGCGTGG CCTGGTGGCT GGTGGCATAA TTGGAGCCTT GCTGGGCACT 
CCTGTAGGAG GCCTGCTGAT GGCATTTCAG AAGTACTCTG GTGAGACTGT TCAGGAAAGA 
AAACAGAAGG ATCGAAAGGC ACTCCATGAG CTAAAACTGG AAGAGTGGAA AGGCAGACTA 
CAAGTTACTG AGCACCTCCC TGAGAAAATT GAAAGTAGTT TACAGGAAGA TGAACCTGAG 
AATGATGCTA AGAAAATTGA AGCACTGCTA AACCTTCCTA GAAACCCTTC AGTAATAGAT 
AAACAAGACA AGGACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_057673.2
CDS	214..1071
Translation	MEVPPPAPRSFLCRALCLFPRVFAAEAVTADSEVLEERQKRLPYVPEPYYPESGWDRLRELFGKDEQQRISKDLANICKTAATAGIIGWVYGGIPAFIHAKQQYIEQSQAEIYHNRFDAVQSAHRAATRGFIRYGWRWGWRTAVFVTIFNTVNTSLNVYRNKDALSHFVIAGAVTGSLFRINVGLRGLVAGGIIGALLGTPVGGLLMAFQKYSGETVQERKQKDRKALHELKLEEWKGRLQVTEHLPEKIESSLQEDEPENDAKKIEALLNLPRNPSVIDKQDKD

Target ORF information:

RefSeq Version	NM_016589.3
Organism	Homo sapiens(human)
Definition	Homo sapiens translocase of inner mitochondrial membrane domain containing 1 (TIMMDC1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_016589.3

ORF Insert Sequence:

ATGGAGGTGC CGCCACCGGC ACCGCGGAGC TTTCTCTGTA GAGCATTGTG CCTATTTCCC 
CGAGTCTTTG CTGCCGAAGC TGTGACTGCC GATTCGGAAG TCCTTGAGGA GCGTCAGAAG 
CGGCTTCCCT ACGTCCCAGA GCCCTATTAC CCGGAATCTG GATGGGACCG CCTCCGGGAG 
CTGTTTGGCA AAGATGAACA GCAGAGAATT TCAAAGGACC TTGCTAATAT CTGTAAGACG 
GCAGCTACAG CAGGCATCAT TGGCTGGGTG TATGGGGGAA TACCAGCTTT TATTCATGCT 
AAACAACAAT ACATTGAGCA GAGCCAGGCA GAAATTTATC ATAACCGGTT TGATGCTGTG 
CAATCTGCAC ATCGTGCTGC CACACGAGGC TTCATTCGTT ATGGCTGGCG CTGGGGTTGG 
AGAACTGCAG TGTTTGTGAC TATATTCAAC ACAGTGAACA CTAGTCTGAA TGTATACCGA 
AATAAAGATG CCTTAAGCCA TTTTGTAATT GCAGGAGCTG TCACGGGAAG TCTTTTTAGG 
ATAAACGTAG GCCTGCGTGG CCTGGTGGCT GGTGGCATAA TTGGAGCCTT GCTGGGCACT 
CCTGTAGGAG GCCTGCTGAT GGCATTTCAG AAGTACTCTG GTGAGACTGT TCAGGAAAGA 
AAACAGAAGG ATCGAAAGGC ACTCCATGAG CTAAAACTGG AAGAGTGGAA AGGCAGACTA 
CAAGTTACTG AGCACCTCCC TGAGAAAATT GAAAGTAGTT TACAGGAAGA TGAACCTGAG 
AATGATGCTA AGAAAATTGA AGCACTGCTA AACCTTCCTA GAAACCCTTC AGTAATAGAT 
AAACAAGACA AGGACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TIMMDC1 ( XM_017006556.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016862045.1 Homo sapiens translocase of inner mitochondrial membrane domain containing 1 (TIMMDC1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu94259
Clone ID Related Accession (Same CDS sequence)	XM_017006556.1
Accession Version	XM_017006556.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 456bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	complex I assembly factor TIMMDC1, mitochondrial isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000003.12) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGAGGTGC CGCCACCGGC ACCGCGGAGC TTTCTCTGTA GAGCATTGTG CCTATTTCCC 
CGAGTCTTTG CTGCCGAAGC TGTGACTGCC GATTCGGAAG TCCTTGAGGA GCGTCAGAAG 
CGGCTTCCCT ACGTCCCAGA GCCCTATTAC CCGGAATCTG GATGGGACCG CCTCCGGGAG 
CTGTTTGGCA AAGACACTCC TGTAGGAGGC CTGCTGATGG CATTTCAGAA GTACTCTGGT 
GAGACTGTTC AGGAAAGAAA ACAGAAGGAT CGAAAGGCAC TCCATGAGCT AAAACTGGAA 
GAGTGGAAAG GCAGACTACA AGTTACTGAG CACCTCCCTG AGAAAATTGA AAGTAGTTTA 
CAGGAAGATG AACCTGAGAA TGATGCTAAG AAAATTGAAG CACTGCTAAA CCTTCCTAGA 
AACCCTTCAG TAATAGATAA ACAAGACAAG GACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016862045.1
CDS	210..665
Translation	MEVPPPAPRSFLCRALCLFPRVFAAEAVTADSEVLEERQKRLPYVPEPYYPESGWDRLRELFGKDTPVGGLLMAFQKYSGETVQERKQKDRKALHELKLEEWKGRLQVTEHLPEKIESSLQEDEPENDAKKIEALLNLPRNPSVIDKQDKD

Target ORF information:

RefSeq Version	XM_017006556.1
Organism	Homo sapiens(human)
Definition	Homo sapiens translocase of inner mitochondrial membrane domain containing 1 (TIMMDC1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017006556.1

ORF Insert Sequence:

ATGGAGGTGC CGCCACCGGC ACCGCGGAGC TTTCTCTGTA GAGCATTGTG CCTATTTCCC 
CGAGTCTTTG CTGCCGAAGC TGTGACTGCC GATTCGGAAG TCCTTGAGGA GCGTCAGAAG 
CGGCTTCCCT ACGTCCCAGA GCCCTATTAC CCGGAATCTG GATGGGACCG CCTCCGGGAG 
CTGTTTGGCA AAGACACTCC TGTAGGAGGC CTGCTGATGG CATTTCAGAA GTACTCTGGT 
GAGACTGTTC AGGAAAGAAA ACAGAAGGAT CGAAAGGCAC TCCATGAGCT AAAACTGGAA 
GAGTGGAAAG GCAGACTACA AGTTACTGAG CACCTCCCTG AGAAAATTGA AAGTAGTTTA 
CAGGAAGATG AACCTGAGAA TGATGCTAAG AAAATTGAAG CACTGCTAAA CCTTCCTAGA 
AACCCTTCAG TAATAGATAA ACAAGACAAG GACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Depletion of C3orf1/TIMMDC1 inhibits migration and proliferation in 95D lung carcinoma cells.
International journal of molecular sciences15(11)20555-71(2014 Nov)
Wu H,Wang W,Xu H

TIMMDC1/C3orf1 functions as a membrane-embedded mitochondrial complex I assembly factor through association with the MCIA complex.
Molecular and cellular biology34(5)847-61(2014 Mar)
Guarani V,Paulo J,Zhai B,Huttlin EL,Gygi SP,Harper JW

Assembly factors for the membrane arm of human complex I.
Proceedings of the National Academy of Sciences of the United States of America110(47)18934-9(2013 Nov)
Andrews B,Carroll J,Ding S,Fearnley IM,Walker JE

Genome-wide association study identifies TNFSF15 and POU2AF1 as susceptibility loci for primary biliary cirrhosis in the Japanese population.
American journal of human genetics91(4)721-8(2012 Oct)
Nakamura M,Nishida N,Kawashima M,Aiba Y,Tanaka A,Yasunami M,Nakamura H,Komori A,Nakamuta M,Zeniya M,Hashimoto E,Ohira H,Yamamoto K,Onji M,Kaneko S,Honda M,Yamagiwa S,Nakao K,Ichida T,Takikawa H,Seike M,Umemura T,Ueno Y,Sakisaka S,Kikuchi K,Ebinuma H,Yamashiki N,Tamura S,Sugawara Y,Mori A,Yagi S,Shirabe K,Taketomi A,Arai K,Monoe K,Ichikawa T,Taniai M,Miyake Y,Kumagi T,Abe M,Yoshizawa K,Joshita S,Shimoda S,Honda K,Takahashi H,Hirano K,Takeyama Y,Harada K,Migita K,Ito M,Yatsuhashi H,Fukushima N,Ota H,Komatsu T,Saoshiro T,Ishida J,Kouno H,Kouno H,Yagura M,Kobayashi M,Muro T,Masaki N,Hirata K,Watanabe Y,Nakamura Y,Shimada M,Hirashima N,Komeda T,Sugi K,Koga M,Ario K,Takesaki E,Maehara Y,Uemoto S,Kokudo N,Tsubouchi H,Mizokami M,Nakanuma Y,Tokunaga K,Ishibashi H

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TIMMDC1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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