PCDH12 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	PCDH12
Entrez Gene ID	51294
Full Name	protocadherin 12
Synonyms	VE-cadherin-2,VECAD2
General protein information	Preferred Names protocadherin 12 Names protocadherin-12 VE-cad-2 VE-cadherin 2 vascular cadherin-2 vascular endothelial cadherin 2
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 5 Map Location: 5q31.3
Summary	This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. The encoded protein consists of an extracellular domain containing 6 cadherin repeats, a transmembrane domain and a cytoplasmic tail that differs from those of the classical cadherins. The gene localizes to the region on chromosome 5 where the protocadherin gene clusters reside. The exon organization of this transcript is similar to that of the gene cluster transcripts, notably the first large exon, but no significant sequence homology exists. The function of this cellular adhesion protein is undetermined but mouse protocadherin 12 does not bind catenins and appears to have no affect on cell migration or growth. [provided by RefSeq, Jul 2008].
Disorder MIM:	605622
Disorder Html:	Microcephaly, seizures, spasticity, and brain calcification, 605622 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_016580.3	NP_057664.1	protocadherin-12 precursor
NM_016580.4	NP_057664.1	protocadherin-12 precursor
XM_024446106.1	XP_024301874.1	protocadherin-12 isoform X1

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Pcdh12	NP_059074.2
Gallus gallus (chicken)	PCDH12	XP_414518.4
Homo sapiens (human)	PCDH12	NP_057664.1
Bos taurus (cattle)	PCDH12	NP_001091580.1
Rattus norvegicus (Norway rat)	Pcdh12	NP_446396.1
Pan troglodytes (chimpanzee)	PCDH12	XP_527055.2
	PCDH12	XP_001094671.2
Canis lupus familiaris (dog)	PCDH12	XP_544319.2
Danio rerio (zebrafish)	pcdh12	XP_683010.5
Xenopus tropicalis (tropical clawed frog)	pcdh12	XP_004912868.1

Gene Ontology
Bibliography

Related articles in PubMed

Loss of function of PCDH12 underlies recessive microcephaly mimicking intrauterine infection.
Aran A, Rosenfeld N, Jaron R, Renbaum P, Zuckerman S, Fridman H, Zeligson S, Segel R, Kohn Y, Kamal L, Kanaan M, Segev Y, Mazaki E, Rabinowitz R, Shen O, Lee M, Walsh T, King MC, Gulsuner S, Levy-Lahad E
Neurology86(21)2016-24(2016 May)

Protocadherin-12 cleavage is a regulated process mediated by ADAM10 protein: evidence of shedding up-regulation in pre-eclampsia.
Bouillot S, Tillet E, Carmona G, Prandini MH, Gauchez AS, Hoffmann P, Alfaidy N, Cand F, Huber P
The Journal of biological chemistry286(17)15195-204(2011 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Genome-wide analysis to determine the genetic cause of a microcephaly syndrome; found that loss of function of PCDH12 leads to recessive congenital microcephaly with profound developmental disability
Title: Loss of function of PCDH12 underlies recessive microcephaly mimicking intrauterine infection.

PCDH12 may play an important role in human placental development, and proteolytic cleavage in response to external factors, such as cytokines and pathological settings, regulates its activity
Title: Protocadherin-12 cleavage is a regulated process mediated by ADAM10 protein: evidence of shedding up-regulation in pre-eclampsia.

Observational study of gene-disease association. (HuGE Navigator)
Title: Polymorphisms in genes involved in neurodevelopment may be associated with altered brain morphology in schizophrenia: preliminary evidence.

The following PCDH12 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PCDH12 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu08561	NM_016580.4 Latest version!	Homo sapiens protocadherin 12 (PCDH12), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	19-21	$643.30 $919.00
OHu08561	XM_024446106.1 Latest version!	Homo sapiens protocadherin 12 (PCDH12), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	20	$643.30 $919.00
View Old Accession Versions >>
OHu08561	NM_016580.3	Homo sapiens protocadherin 12 (PCDH12), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	20	$643.30 $919.00
Hide Old Accession Versions >>

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

PCDH12 ( NM_016580.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_057664.1 Homo sapiens protocadherin 12 (PCDH12), mRNA.

Price & Availability↑

CloneID	OHu08561
Clone ID Related Accession (Same CDS sequence)	NM_016580.3 , NM_016580.4 , XM_024446106.1
Accession Version	NM_016580.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3555bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-02
Organism	Homo sapiens(human)
Product	protocadherin-12 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF240635.1, AF231025.1, AC005740.1 and CA418447.1. On Dec 23, 2019 this sequence version replaced NM_016580.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF240635.1, AF231025.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on manual assertion, conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGATGCAAC TTCTGCAACT TCTGCTGGGG CTTTTGGGGC CAGGTGGCTA CTTATTTCTT 
TTAGGGGATT GTCAGGAGGT GACCACTCTC ACGGTGAAAT ACCAAGTGTC AGAGGAAGTG 
CCATCTGGTA CAGTGATCGG GAAGCTGTCC CAGGAACTGG GCCGGGAGGA GAGGCGGAGG 
CAAGCTGGGG CTGCCTTCCA GGTGTTGCAG CTGCCTCAGG CGCTCCCCAT TCAGGTGGAC 
TCTGAGGAAG GCTTGCTCAG CACAGGCAGG CGGCTGGATC GAGAGCAGCT GTGCCGACAG 
TGGGATCCCT GCCTGGTTTC CTTTGATGTG CTTGCCACAG GGGATTTGGC TCTGATCCAT 
GTGGAGATCC AAGTGCTGGA CATCAATGAC CACCAGCCAC GGTTTCCCAA AGGCGAGCAG 
GAGCTGGAAA TCTCTGAGAG CGCCTCTCTG CGAACCCGGA TCCCCCTGGA CAGAGCTCTT 
GACCCAGACA CAGGCCCTAA CACCCTGCAC ACCTACACTC TGTCTCCCAG TGAGCACTTT 
GCCTTGGATG TCATTGTGGG CCCTGATGAG ACCAAACATG CAGAACTCAT AGTGGTGAAG 
GAGCTGGACA GGGAAATCCA TTCATTTTTT GATCTGGTGT TAACTGCCTA TGACAATGGG 
AACCCCCCCA AGTCAGGTAC CAGCTTGGTC AAGGTCAACG TCTTGGACTC CAATGACAAT 
AGCCCTGCGT TTGCTGAGAG TTCACTGGCA CTGGAAATCC AAGAAGATGC TGCACCTGGT 
ACGCTTCTCA TAAAACTGAC CGCCACAGAC CCTGACCAAG GCCCCAATGG GGAGGTGGAG 
TTCTTCCTCA GTAAGCACAT GCCTCCAGAG GTGCTGGACA CCTTCAGTAT TGATGCCAAG 
ACAGGCCAGG TCATTCTGCG TCGACCTCTA GACTATGAAA AGAACCCTGC CTACGAGGTG 
GATGTTCAGG CAAGGGACCT GGGTCCCAAT CCTATCCCAG CCCATTGCAA AGTTCTCATC 
AAGGTTCTGG ATGTCAATGA CAACATCCCA AGCATCCACG TCACATGGGC CTCCCAGCCA 
TCACTGGTGT CAGAAGCTCT TCCCAAGGAC AGTTTTATTG CTCTTGTCAT GGCAGATGAC 
TTGGATTCAG GACACAATGG TTTGGTCCAC TGCTGGCTGA GCCAAGAGCT GGGCCACTTC 
AGGCTGAAAA GAACTAATGG CAACACATAC ATGTTGCTAA CCAATGCCAC ACTGGACAGA 
GAGCAGTGGC CCAAATATAC CCTCACTCTG TTAGCCCAAG ACCAAGGACT CCAGCCCTTA 
TCAGCCAAGA AACAGCTCAG CATTCAGATC AGTGACATCA ACGACAATGC ACCTGTGTTT 
GAGAAAAGCA GGTATGAAGT CTCCACGCGG GAAAACAACT TACCCTCTCT TCACCTCATT 
ACCATCAAGG CTCATGATGC AGACTTGGGC ATTAATGGAA AAGTCTCATA CCGCATCCAG 
GACTCCCCAG TTGCTCACTT AGTAGCTATT GACTCCAACA CAGGAGAGGT CACTGCTCAG 
AGGTCACTGA ACTATGAAGA GATGGCCGGC TTTGAGTTCC AGGTGATCGC AGAGGACAGC 
GGGCAACCCA TGCTTGCATC CAGTGTCTCT GTGTGGGTCA GCCTCTTGGA TGCCAATGAT 
AATGCCCCAG AGGTGGTCCA GCCTGTGCTC AGCGATGGAA AAGCCAGCCT CTCCGTGCTT 
GTGAATGCCT CCACAGGCCA CCTGCTGGTG CCCATCGAGA CTCCCAATGG CTTGGGCCCA 
GCGGGCACTG ACACACCTCC ACTGGCCACT CACAGCTCCC GGCCATTCCT TTTGACAACC 
ATTGTGGCAA GAGATGCAGA CTCGGGGGCA AATGGAGAGC CCCTCTACAG CATCCGCAGT 
GGAAATGAAG CCCACCTCTT CATCCTCAAC CCTCATACGG GGCAGCTGTT CGTCAATGTC 
ACCAATGCCA GCAGCCTCAT TGGGAGTGAG TGGGAGCTGG AGATAGTAGT AGAGGACCAG 
GGAAGCCCCC CCTTACAGAC CCGAGCCCTG TTGAGGGTCA TGTTTGTCAC CAGTGTGGAC 
CACCTGAGGG ACTCAGCCCG CAAGCCTGGG GCCTTGAGCA TGTCGATGCT GACGGTGATC 
TGCCTGGCTG TACTGTTGGG CATCTTCGGG TTGATCCTGG CTTTGTTCAT GTCCATCTGC 
CGGACAGAAA AGAAGGACAA CAGGGCCTAC AACTGTCGGG AGGCCGAGTC CACCTACCGC 
CAGCAGCCCA AGAGGCCCCA GAAACACATT CAGAAGGCAG ACATCCACCT CGTGCCTGTG 
CTCAGGGGTC AGGCAGGTGA GCCTTGTGAA GTCGGGCAGT CCCACAAAGA TGTGGACAAG 
GAGGCGATGA TGGAAGCAGG CTGGGACCCC TGCCTGCAGG CCCCCTTCCA CCTCACCCCG 
ACCCTGTACA GGACGCTGCG TAATCAAGGC AACCAGGGAG CACCGGCGGA GAGCCGAGAG 
GTGCTGCAAG ACACGGTCAA CCTCCTTTTC AACCATCCCA GGCAGAGGAA TGCCTCCCGG 
GAGAACCTGA ACCTTCCCGA GCCCCAGCCT GCCACAGGCC AGCCACGTTC CAGGCCTCTG 
AAGGTTGCAG GCAGCCCCAC AGGGAGGCTG GCTGGAGACC AGGGCAGTGA GGAAGCCCCA 
CAGAGGCCAC CAGCCTCCTC TGCAACCCTG AGACGGCAGC GACATCTCAA TGGCAAAGTG 
TCCCCTGAGA AAGAATCAGG GCCCCGTCAG ATCCTGCGGA GCCTGGTCCG GCTGTCTGTG 
GCTGCCTTCG CCGAGCGGAA CCCCGTGGAG GAGCTCACTG TGGATTCTCC TCCTGTTCAG 
CAAATCTCCC AGCTGCTGTC CTTGCTGCAT CAGGGCCAAT TCCAGCCCAA ACCAAACCAC 
CGAGGAAATA AGTACTTGGC CAAGCCAGGA GGCAGCAGGA GTGCAATCCC AGACACAGAT 
GGCCCAAGTG CAAGGGCTGG AGGCCAGACA GACCCAGAAC AGGAGGAAGG GCCTTTGGAT 
CCTGAAGAGG ACCTCTCTGT GAAGCAACTG CTAGAAGAAG AGCTGTCAAG TCTGCTGGAC 
CCCAGCACAG GTCTGGCCCT GGACCGGCTG AGCGCCCCTG ACCCGGCCTG GATGGCGAGA 
CTCTCTTTGC CCCTCACCAC CAACTACCGT GACAATGTGA TCTCCCCGGA TGCTGCAGCC 
ACGGAGGAGC CAAGGACCTT CCAGACGTTC GGCAAGGCAG AGGCACCAGA GCTGAGCCCA 
ACAGGCACGA GGCTGGCCAG CACCTTTGTC TCGGAGATGA GCTCACTGCT GGAGATGCTG 
CTGGAACAGC GCTCCAGCAT GCCCGTGGAG GCCGCCTCCG AGGCGCTGCG GCGGCTCTCG 
GTCTGCGGGA GGACCCTCAG TTTAGACTTG GCCACCAGTG CAGCCTCAGG CATGAAAGTG 
CAAGGGGACC CAGGTGGAAA GACGGGGACT GAGGGCAAGA GCAGAGGCAG CAGCAGCAGC 
AGCAGGTGCC TGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_057664.1
CDS	352..3906
Translation	MMQLLQLLLGLLGPGGYLFLLGDCQEVTTLTVKYQVSEEVPSGTVIGKLSQELGREERRRQAGAAFQVLQLPQALPIQVDSEEGLLSTGRRLDREQLCRQWDPCLVSFDVLATGDLALIHVEIQVLDINDHQPRFPKGEQELEISESASLRTRIPLDRALDPDTGPNTLHTYTLSPSEHFALDVIVGPDETKHAELIVVKELDREIHSFFDLVLTAYDNGNPPKSGTSLVKVNVLDSNDNSPAFAESSLALEIQEDAAPGTLLIKLTATDPDQGPNGEVEFFLSKHMPPEVLDTFSIDAKTGQVILRRPLDYEKNPAYEVDVQARDLGPNPIPAHCKVLIKVLDVNDNIPSIHVTWASQPSLVSEALPKDSFIALVMADDLDSGHNGLVHCWLSQELGHFRLKRTNGNTYMLLTNATLDREQWPKYTLTLLAQDQGLQPLSAKKQLSIQISDINDNAPVFEKSRYEVSTRENNLPSLHLITIKAHDADLGINGKVSYRIQDSPVAHLVAIDSNTGEVTAQRSLNYEEMAGFEFQVIAEDSGQPMLASSVSVWVSLLDANDNAPEVVQPVLSDGKASLSVLVNASTGHLLVPIETPNGLGPAGTDTPPLATHSSRPFLLTTIVARDADSGANGEPLYSIRSGNEAHLFILNPHTGQLFVNVTNASSLIGSEWELEIVVEDQGSPPLQTRALLRVMFVTSVDHLRDSARKPGALSMSMLTVICLAVLLGIFGLILALFMSICRTEKKDNRAYNCREAESTYRQQPKRPQKHIQKADIHLVPVLRGQAGEPCEVGQSHKDVDKEAMMEAGWDPCLQAPFHLTPTLYRTLRNQGNQGAPAESREVLQDTVNLLFNHPRQRNASRENLNLPEPQPATGQPRSRPLKVAGSPTGRLAGDQGSEEAPQRPPASSATLRRQRHLNGKVSPEKESGPRQILRSLVRLSVAAFAERNPVEELTVDSPPVQQISQLLSLLHQGQFQPKPNHRGNKYLAKPGGSRSAIPDTDGPSARAGGQTDPEQEEGPLDPEEDLSVKQLLEEELSSLLDPSTGLALDRLSAPDPAWMARLSLPLTTNYRDNVISPDAAATEEPRTFQTFGKAEAPELSPTGTRLASTFVSEMSSLLEMLLEQRSSMPVEAASEALRRLSVCGRTLSLDLATSAASGMKVQGDPGGKTGTEGKSRGSSSSSRCL

Target ORF information:

RefSeq Version	NM_016580.4
Organism	Homo sapiens(human)
Definition	Homo sapiens protocadherin 12 (PCDH12), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_016580.4

ORF Insert Sequence:

ATGATGCAAC TTCTGCAACT TCTGCTGGGG CTTTTGGGGC CAGGTGGCTA CTTATTTCTT 
TTAGGGGATT GTCAGGAGGT GACCACTCTC ACGGTGAAAT ACCAAGTGTC AGAGGAAGTG 
CCATCTGGTA CAGTGATCGG GAAGCTGTCC CAGGAACTGG GCCGGGAGGA GAGGCGGAGG 
CAAGCTGGGG CTGCCTTCCA GGTGTTGCAG CTGCCTCAGG CGCTCCCCAT TCAGGTGGAC 
TCTGAGGAAG GCTTGCTCAG CACAGGCAGG CGGCTGGATC GAGAGCAGCT GTGCCGACAG 
TGGGATCCCT GCCTGGTTTC CTTTGATGTG CTTGCCACAG GGGATTTGGC TCTGATCCAT 
GTGGAGATCC AAGTGCTGGA CATCAATGAC CACCAGCCAC GGTTTCCCAA AGGCGAGCAG 
GAGCTGGAAA TCTCTGAGAG CGCCTCTCTG CGAACCCGGA TCCCCCTGGA CAGAGCTCTT 
GACCCAGACA CAGGCCCTAA CACCCTGCAC ACCTACACTC TGTCTCCCAG TGAGCACTTT 
GCCTTGGATG TCATTGTGGG CCCTGATGAG ACCAAACATG CAGAACTCAT AGTGGTGAAG 
GAGCTGGACA GGGAAATCCA TTCATTTTTT GATCTGGTGT TAACTGCCTA TGACAATGGG 
AACCCCCCCA AGTCAGGTAC CAGCTTGGTC AAGGTCAACG TCTTGGACTC CAATGACAAT 
AGCCCTGCGT TTGCTGAGAG TTCACTGGCA CTGGAAATCC AAGAAGATGC TGCACCTGGT 
ACGCTTCTCA TAAAACTGAC CGCCACAGAC CCTGACCAAG GCCCCAATGG GGAGGTGGAG 
TTCTTCCTCA GTAAGCACAT GCCTCCAGAG GTGCTGGACA CCTTCAGTAT TGATGCCAAG 
ACAGGCCAGG TCATTCTGCG TCGACCTCTA GACTATGAAA AGAACCCTGC CTACGAGGTG 
GATGTTCAGG CAAGGGACCT GGGTCCCAAT CCTATCCCAG CCCATTGCAA AGTTCTCATC 
AAGGTTCTGG ATGTCAATGA CAACATCCCA AGCATCCACG TCACATGGGC CTCCCAGCCA 
TCACTGGTGT CAGAAGCTCT TCCCAAGGAC AGTTTTATTG CTCTTGTCAT GGCAGATGAC 
TTGGATTCAG GACACAATGG TTTGGTCCAC TGCTGGCTGA GCCAAGAGCT GGGCCACTTC 
AGGCTGAAAA GAACTAATGG CAACACATAC ATGTTGCTAA CCAATGCCAC ACTGGACAGA 
GAGCAGTGGC CCAAATATAC CCTCACTCTG TTAGCCCAAG ACCAAGGACT CCAGCCCTTA 
TCAGCCAAGA AACAGCTCAG CATTCAGATC AGTGACATCA ACGACAATGC ACCTGTGTTT 
GAGAAAAGCA GGTATGAAGT CTCCACGCGG GAAAACAACT TACCCTCTCT TCACCTCATT 
ACCATCAAGG CTCATGATGC AGACTTGGGC ATTAATGGAA AAGTCTCATA CCGCATCCAG 
GACTCCCCAG TTGCTCACTT AGTAGCTATT GACTCCAACA CAGGAGAGGT CACTGCTCAG 
AGGTCACTGA ACTATGAAGA GATGGCCGGC TTTGAGTTCC AGGTGATCGC AGAGGACAGC 
GGGCAACCCA TGCTTGCATC CAGTGTCTCT GTGTGGGTCA GCCTCTTGGA TGCCAATGAT 
AATGCCCCAG AGGTGGTCCA GCCTGTGCTC AGCGATGGAA AAGCCAGCCT CTCCGTGCTT 
GTGAATGCCT CCACAGGCCA CCTGCTGGTG CCCATCGAGA CTCCCAATGG CTTGGGCCCA 
GCGGGCACTG ACACACCTCC ACTGGCCACT CACAGCTCCC GGCCATTCCT TTTGACAACC 
ATTGTGGCAA GAGATGCAGA CTCGGGGGCA AATGGAGAGC CCCTCTACAG CATCCGCAGT 
GGAAATGAAG CCCACCTCTT CATCCTCAAC CCTCATACGG GGCAGCTGTT CGTCAATGTC 
ACCAATGCCA GCAGCCTCAT TGGGAGTGAG TGGGAGCTGG AGATAGTAGT AGAGGACCAG 
GGAAGCCCCC CCTTACAGAC CCGAGCCCTG TTGAGGGTCA TGTTTGTCAC CAGTGTGGAC 
CACCTGAGGG ACTCAGCCCG CAAGCCTGGG GCCTTGAGCA TGTCGATGCT GACGGTGATC 
TGCCTGGCTG TACTGTTGGG CATCTTCGGG TTGATCCTGG CTTTGTTCAT GTCCATCTGC 
CGGACAGAAA AGAAGGACAA CAGGGCCTAC AACTGTCGGG AGGCCGAGTC CACCTACCGC 
CAGCAGCCCA AGAGGCCCCA GAAACACATT CAGAAGGCAG ACATCCACCT CGTGCCTGTG 
CTCAGGGGTC AGGCAGGTGA GCCTTGTGAA GTCGGGCAGT CCCACAAAGA TGTGGACAAG 
GAGGCGATGA TGGAAGCAGG CTGGGACCCC TGCCTGCAGG CCCCCTTCCA CCTCACCCCG 
ACCCTGTACA GGACGCTGCG TAATCAAGGC AACCAGGGAG CACCGGCGGA GAGCCGAGAG 
GTGCTGCAAG ACACGGTCAA CCTCCTTTTC AACCATCCCA GGCAGAGGAA TGCCTCCCGG 
GAGAACCTGA ACCTTCCCGA GCCCCAGCCT GCCACAGGCC AGCCACGTTC CAGGCCTCTG 
AAGGTTGCAG GCAGCCCCAC AGGGAGGCTG GCTGGAGACC AGGGCAGTGA GGAAGCCCCA 
CAGAGGCCAC CAGCCTCCTC TGCAACCCTG AGACGGCAGC GACATCTCAA TGGCAAAGTG 
TCCCCTGAGA AAGAATCAGG GCCCCGTCAG ATCCTGCGGA GCCTGGTCCG GCTGTCTGTG 
GCTGCCTTCG CCGAGCGGAA CCCCGTGGAG GAGCTCACTG TGGATTCTCC TCCTGTTCAG 
CAAATCTCCC AGCTGCTGTC CTTGCTGCAT CAGGGCCAAT TCCAGCCCAA ACCAAACCAC 
CGAGGAAATA AGTACTTGGC CAAGCCAGGA GGCAGCAGGA GTGCAATCCC AGACACAGAT 
GGCCCAAGTG CAAGGGCTGG AGGCCAGACA GACCCAGAAC AGGAGGAAGG GCCTTTGGAT 
CCTGAAGAGG ACCTCTCTGT GAAGCAACTG CTAGAAGAAG AGCTGTCAAG TCTGCTGGAC 
CCCAGCACAG GTCTGGCCCT GGACCGGCTG AGCGCCCCTG ACCCGGCCTG GATGGCGAGA 
CTCTCTTTGC CCCTCACCAC CAACTACCGT GACAATGTGA TCTCCCCGGA TGCTGCAGCC 
ACGGAGGAGC CAAGGACCTT CCAGACGTTC GGCAAGGCAG AGGCACCAGA GCTGAGCCCA 
ACAGGCACGA GGCTGGCCAG CACCTTTGTC TCGGAGATGA GCTCACTGCT GGAGATGCTG 
CTGGAACAGC GCTCCAGCAT GCCCGTGGAG GCCGCCTCCG AGGCGCTGCG GCGGCTCTCG 
GTCTGCGGGA GGACCCTCAG TTTAGACTTG GCCACCAGTG CAGCCTCAGG CATGAAAGTG 
CAAGGGGACC CAGGTGGAAA GACGGGGACT GAGGGCAAGA GCAGAGGCAG CAGCAGCAGC 
AGCAGGTGCC TGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PCDH12 ( NM_016580.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_057664.1 Homo sapiens protocadherin 12 (PCDH12), mRNA.

Price & Availability↑

CloneID	OHu08561
Clone ID Related Accession (Same CDS sequence)	NM_016580.3 , NM_016580.4 , XM_024446106.1
Accession Version	NM_016580.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3555bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-05-03
Organism	Homo sapiens(human)
Product	protocadherin-12 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF240635.1, AF231025.1, AC005740.1 and CA418447.1. On Jul 12, 2013 this sequence version replaced NM_016580.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF240635.1, AK024140.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2146236, SAMEA2151358 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGATGCAAC TTCTGCAACT TCTGCTGGGG CTTTTGGGGC CAGGTGGCTA CTTATTTCTT 
TTAGGGGATT GTCAGGAGGT GACCACTCTC ACGGTGAAAT ACCAAGTGTC AGAGGAAGTG 
CCATCTGGTA CAGTGATCGG GAAGCTGTCC CAGGAACTGG GCCGGGAGGA GAGGCGGAGG 
CAAGCTGGGG CTGCCTTCCA GGTGTTGCAG CTGCCTCAGG CGCTCCCCAT TCAGGTGGAC 
TCTGAGGAAG GCTTGCTCAG CACAGGCAGG CGGCTGGATC GAGAGCAGCT GTGCCGACAG 
TGGGATCCCT GCCTGGTTTC CTTTGATGTG CTTGCCACAG GGGATTTGGC TCTGATCCAT 
GTGGAGATCC AAGTGCTGGA CATCAATGAC CACCAGCCAC GGTTTCCCAA AGGCGAGCAG 
GAGCTGGAAA TCTCTGAGAG CGCCTCTCTG CGAACCCGGA TCCCCCTGGA CAGAGCTCTT 
GACCCAGACA CAGGCCCTAA CACCCTGCAC ACCTACACTC TGTCTCCCAG TGAGCACTTT 
GCCTTGGATG TCATTGTGGG CCCTGATGAG ACCAAACATG CAGAACTCAT AGTGGTGAAG 
GAGCTGGACA GGGAAATCCA TTCATTTTTT GATCTGGTGT TAACTGCCTA TGACAATGGG 
AACCCCCCCA AGTCAGGTAC CAGCTTGGTC AAGGTCAACG TCTTGGACTC CAATGACAAT 
AGCCCTGCGT TTGCTGAGAG TTCACTGGCA CTGGAAATCC AAGAAGATGC TGCACCTGGT 
ACGCTTCTCA TAAAACTGAC CGCCACAGAC CCTGACCAAG GCCCCAATGG GGAGGTGGAG 
TTCTTCCTCA GTAAGCACAT GCCTCCAGAG GTGCTGGACA CCTTCAGTAT TGATGCCAAG 
ACAGGCCAGG TCATTCTGCG TCGACCTCTA GACTATGAAA AGAACCCTGC CTACGAGGTG 
GATGTTCAGG CAAGGGACCT GGGTCCCAAT CCTATCCCAG CCCATTGCAA AGTTCTCATC 
AAGGTTCTGG ATGTCAATGA CAACATCCCA AGCATCCACG TCACATGGGC CTCCCAGCCA 
TCACTGGTGT CAGAAGCTCT TCCCAAGGAC AGTTTTATTG CTCTTGTCAT GGCAGATGAC 
TTGGATTCAG GACACAATGG TTTGGTCCAC TGCTGGCTGA GCCAAGAGCT GGGCCACTTC 
AGGCTGAAAA GAACTAATGG CAACACATAC ATGTTGCTAA CCAATGCCAC ACTGGACAGA 
GAGCAGTGGC CCAAATATAC CCTCACTCTG TTAGCCCAAG ACCAAGGACT CCAGCCCTTA 
TCAGCCAAGA AACAGCTCAG CATTCAGATC AGTGACATCA ACGACAATGC ACCTGTGTTT 
GAGAAAAGCA GGTATGAAGT CTCCACGCGG GAAAACAACT TACCCTCTCT TCACCTCATT 
ACCATCAAGG CTCATGATGC AGACTTGGGC ATTAATGGAA AAGTCTCATA CCGCATCCAG 
GACTCCCCAG TTGCTCACTT AGTAGCTATT GACTCCAACA CAGGAGAGGT CACTGCTCAG 
AGGTCACTGA ACTATGAAGA GATGGCCGGC TTTGAGTTCC AGGTGATCGC AGAGGACAGC 
GGGCAACCCA TGCTTGCATC CAGTGTCTCT GTGTGGGTCA GCCTCTTGGA TGCCAATGAT 
AATGCCCCAG AGGTGGTCCA GCCTGTGCTC AGCGATGGAA AAGCCAGCCT CTCCGTGCTT 
GTGAATGCCT CCACAGGCCA CCTGCTGGTG CCCATCGAGA CTCCCAATGG CTTGGGCCCA 
GCGGGCACTG ACACACCTCC ACTGGCCACT CACAGCTCCC GGCCATTCCT TTTGACAACC 
ATTGTGGCAA GAGATGCAGA CTCGGGGGCA AATGGAGAGC CCCTCTACAG CATCCGCAGT 
GGAAATGAAG CCCACCTCTT CATCCTCAAC CCTCATACGG GGCAGCTGTT CGTCAATGTC 
ACCAATGCCA GCAGCCTCAT TGGGAGTGAG TGGGAGCTGG AGATAGTAGT AGAGGACCAG 
GGAAGCCCCC CCTTACAGAC CCGAGCCCTG TTGAGGGTCA TGTTTGTCAC CAGTGTGGAC 
CACCTGAGGG ACTCAGCCCG CAAGCCTGGG GCCTTGAGCA TGTCGATGCT GACGGTGATC 
TGCCTGGCTG TACTGTTGGG CATCTTCGGG TTGATCCTGG CTTTGTTCAT GTCCATCTGC 
CGGACAGAAA AGAAGGACAA CAGGGCCTAC AACTGTCGGG AGGCCGAGTC CACCTACCGC 
CAGCAGCCCA AGAGGCCCCA GAAACACATT CAGAAGGCAG ACATCCACCT CGTGCCTGTG 
CTCAGGGGTC AGGCAGGTGA GCCTTGTGAA GTCGGGCAGT CCCACAAAGA TGTGGACAAG 
GAGGCGATGA TGGAAGCAGG CTGGGACCCC TGCCTGCAGG CCCCCTTCCA CCTCACCCCG 
ACCCTGTACA GGACGCTGCG TAATCAAGGC AACCAGGGAG CACCGGCGGA GAGCCGAGAG 
GTGCTGCAAG ACACGGTCAA CCTCCTTTTC AACCATCCCA GGCAGAGGAA TGCCTCCCGG 
GAGAACCTGA ACCTTCCCGA GCCCCAGCCT GCCACAGGCC AGCCACGTTC CAGGCCTCTG 
AAGGTTGCAG GCAGCCCCAC AGGGAGGCTG GCTGGAGACC AGGGCAGTGA GGAAGCCCCA 
CAGAGGCCAC CAGCCTCCTC TGCAACCCTG AGACGGCAGC GACATCTCAA TGGCAAAGTG 
TCCCCTGAGA AAGAATCAGG GCCCCGTCAG ATCCTGCGGA GCCTGGTCCG GCTGTCTGTG 
GCTGCCTTCG CCGAGCGGAA CCCCGTGGAG GAGCTCACTG TGGATTCTCC TCCTGTTCAG 
CAAATCTCCC AGCTGCTGTC CTTGCTGCAT CAGGGCCAAT TCCAGCCCAA ACCAAACCAC 
CGAGGAAATA AGTACTTGGC CAAGCCAGGA GGCAGCAGGA GTGCAATCCC AGACACAGAT 
GGCCCAAGTG CAAGGGCTGG AGGCCAGACA GACCCAGAAC AGGAGGAAGG GCCTTTGGAT 
CCTGAAGAGG ACCTCTCTGT GAAGCAACTG CTAGAAGAAG AGCTGTCAAG TCTGCTGGAC 
CCCAGCACAG GTCTGGCCCT GGACCGGCTG AGCGCCCCTG ACCCGGCCTG GATGGCGAGA 
CTCTCTTTGC CCCTCACCAC CAACTACCGT GACAATGTGA TCTCCCCGGA TGCTGCAGCC 
ACGGAGGAGC CAAGGACCTT CCAGACGTTC GGCAAGGCAG AGGCACCAGA GCTGAGCCCA 
ACAGGCACGA GGCTGGCCAG CACCTTTGTC TCGGAGATGA GCTCACTGCT GGAGATGCTG 
CTGGAACAGC GCTCCAGCAT GCCCGTGGAG GCCGCCTCCG AGGCGCTGCG GCGGCTCTCG 
GTCTGCGGGA GGACCCTCAG TTTAGACTTG GCCACCAGTG CAGCCTCAGG CATGAAAGTG 
CAAGGGGACC CAGGTGGAAA GACGGGGACT GAGGGCAAGA GCAGAGGCAG CAGCAGCAGC 
AGCAGGTGCC TGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_057664.1
CDS	1212..4766
Translation	MMQLLQLLLGLLGPGGYLFLLGDCQEVTTLTVKYQVSEEVPSGTVIGKLSQELGREERRRQAGAAFQVLQLPQALPIQVDSEEGLLSTGRRLDREQLCRQWDPCLVSFDVLATGDLALIHVEIQVLDINDHQPRFPKGEQELEISESASLRTRIPLDRALDPDTGPNTLHTYTLSPSEHFALDVIVGPDETKHAELIVVKELDREIHSFFDLVLTAYDNGNPPKSGTSLVKVNVLDSNDNSPAFAESSLALEIQEDAAPGTLLIKLTATDPDQGPNGEVEFFLSKHMPPEVLDTFSIDAKTGQVILRRPLDYEKNPAYEVDVQARDLGPNPIPAHCKVLIKVLDVNDNIPSIHVTWASQPSLVSEALPKDSFIALVMADDLDSGHNGLVHCWLSQELGHFRLKRTNGNTYMLLTNATLDREQWPKYTLTLLAQDQGLQPLSAKKQLSIQISDINDNAPVFEKSRYEVSTRENNLPSLHLITIKAHDADLGINGKVSYRIQDSPVAHLVAIDSNTGEVTAQRSLNYEEMAGFEFQVIAEDSGQPMLASSVSVWVSLLDANDNAPEVVQPVLSDGKASLSVLVNASTGHLLVPIETPNGLGPAGTDTPPLATHSSRPFLLTTIVARDADSGANGEPLYSIRSGNEAHLFILNPHTGQLFVNVTNASSLIGSEWELEIVVEDQGSPPLQTRALLRVMFVTSVDHLRDSARKPGALSMSMLTVICLAVLLGIFGLILALFMSICRTEKKDNRAYNCREAESTYRQQPKRPQKHIQKADIHLVPVLRGQAGEPCEVGQSHKDVDKEAMMEAGWDPCLQAPFHLTPTLYRTLRNQGNQGAPAESREVLQDTVNLLFNHPRQRNASRENLNLPEPQPATGQPRSRPLKVAGSPTGRLAGDQGSEEAPQRPPASSATLRRQRHLNGKVSPEKESGPRQILRSLVRLSVAAFAERNPVEELTVDSPPVQQISQLLSLLHQGQFQPKPNHRGNKYLAKPGGSRSAIPDTDGPSARAGGQTDPEQEEGPLDPEEDLSVKQLLEEELSSLLDPSTGLALDRLSAPDPAWMARLSLPLTTNYRDNVISPDAAATEEPRTFQTFGKAEAPELSPTGTRLASTFVSEMSSLLEMLLEQRSSMPVEAASEALRRLSVCGRTLSLDLATSAASGMKVQGDPGGKTGTEGKSRGSSSSSRCL

Target ORF information:

RefSeq Version	NM_016580.3
Organism	Homo sapiens(human)
Definition	Homo sapiens protocadherin 12 (PCDH12), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_016580.3

ORF Insert Sequence:

ATGATGCAAC TTCTGCAACT TCTGCTGGGG CTTTTGGGGC CAGGTGGCTA CTTATTTCTT 
TTAGGGGATT GTCAGGAGGT GACCACTCTC ACGGTGAAAT ACCAAGTGTC AGAGGAAGTG 
CCATCTGGTA CAGTGATCGG GAAGCTGTCC CAGGAACTGG GCCGGGAGGA GAGGCGGAGG 
CAAGCTGGGG CTGCCTTCCA GGTGTTGCAG CTGCCTCAGG CGCTCCCCAT TCAGGTGGAC 
TCTGAGGAAG GCTTGCTCAG CACAGGCAGG CGGCTGGATC GAGAGCAGCT GTGCCGACAG 
TGGGATCCCT GCCTGGTTTC CTTTGATGTG CTTGCCACAG GGGATTTGGC TCTGATCCAT 
GTGGAGATCC AAGTGCTGGA CATCAATGAC CACCAGCCAC GGTTTCCCAA AGGCGAGCAG 
GAGCTGGAAA TCTCTGAGAG CGCCTCTCTG CGAACCCGGA TCCCCCTGGA CAGAGCTCTT 
GACCCAGACA CAGGCCCTAA CACCCTGCAC ACCTACACTC TGTCTCCCAG TGAGCACTTT 
GCCTTGGATG TCATTGTGGG CCCTGATGAG ACCAAACATG CAGAACTCAT AGTGGTGAAG 
GAGCTGGACA GGGAAATCCA TTCATTTTTT GATCTGGTGT TAACTGCCTA TGACAATGGG 
AACCCCCCCA AGTCAGGTAC CAGCTTGGTC AAGGTCAACG TCTTGGACTC CAATGACAAT 
AGCCCTGCGT TTGCTGAGAG TTCACTGGCA CTGGAAATCC AAGAAGATGC TGCACCTGGT 
ACGCTTCTCA TAAAACTGAC CGCCACAGAC CCTGACCAAG GCCCCAATGG GGAGGTGGAG 
TTCTTCCTCA GTAAGCACAT GCCTCCAGAG GTGCTGGACA CCTTCAGTAT TGATGCCAAG 
ACAGGCCAGG TCATTCTGCG TCGACCTCTA GACTATGAAA AGAACCCTGC CTACGAGGTG 
GATGTTCAGG CAAGGGACCT GGGTCCCAAT CCTATCCCAG CCCATTGCAA AGTTCTCATC 
AAGGTTCTGG ATGTCAATGA CAACATCCCA AGCATCCACG TCACATGGGC CTCCCAGCCA 
TCACTGGTGT CAGAAGCTCT TCCCAAGGAC AGTTTTATTG CTCTTGTCAT GGCAGATGAC 
TTGGATTCAG GACACAATGG TTTGGTCCAC TGCTGGCTGA GCCAAGAGCT GGGCCACTTC 
AGGCTGAAAA GAACTAATGG CAACACATAC ATGTTGCTAA CCAATGCCAC ACTGGACAGA 
GAGCAGTGGC CCAAATATAC CCTCACTCTG TTAGCCCAAG ACCAAGGACT CCAGCCCTTA 
TCAGCCAAGA AACAGCTCAG CATTCAGATC AGTGACATCA ACGACAATGC ACCTGTGTTT 
GAGAAAAGCA GGTATGAAGT CTCCACGCGG GAAAACAACT TACCCTCTCT TCACCTCATT 
ACCATCAAGG CTCATGATGC AGACTTGGGC ATTAATGGAA AAGTCTCATA CCGCATCCAG 
GACTCCCCAG TTGCTCACTT AGTAGCTATT GACTCCAACA CAGGAGAGGT CACTGCTCAG 
AGGTCACTGA ACTATGAAGA GATGGCCGGC TTTGAGTTCC AGGTGATCGC AGAGGACAGC 
GGGCAACCCA TGCTTGCATC CAGTGTCTCT GTGTGGGTCA GCCTCTTGGA TGCCAATGAT 
AATGCCCCAG AGGTGGTCCA GCCTGTGCTC AGCGATGGAA AAGCCAGCCT CTCCGTGCTT 
GTGAATGCCT CCACAGGCCA CCTGCTGGTG CCCATCGAGA CTCCCAATGG CTTGGGCCCA 
GCGGGCACTG ACACACCTCC ACTGGCCACT CACAGCTCCC GGCCATTCCT TTTGACAACC 
ATTGTGGCAA GAGATGCAGA CTCGGGGGCA AATGGAGAGC CCCTCTACAG CATCCGCAGT 
GGAAATGAAG CCCACCTCTT CATCCTCAAC CCTCATACGG GGCAGCTGTT CGTCAATGTC 
ACCAATGCCA GCAGCCTCAT TGGGAGTGAG TGGGAGCTGG AGATAGTAGT AGAGGACCAG 
GGAAGCCCCC CCTTACAGAC CCGAGCCCTG TTGAGGGTCA TGTTTGTCAC CAGTGTGGAC 
CACCTGAGGG ACTCAGCCCG CAAGCCTGGG GCCTTGAGCA TGTCGATGCT GACGGTGATC 
TGCCTGGCTG TACTGTTGGG CATCTTCGGG TTGATCCTGG CTTTGTTCAT GTCCATCTGC 
CGGACAGAAA AGAAGGACAA CAGGGCCTAC AACTGTCGGG AGGCCGAGTC CACCTACCGC 
CAGCAGCCCA AGAGGCCCCA GAAACACATT CAGAAGGCAG ACATCCACCT CGTGCCTGTG 
CTCAGGGGTC AGGCAGGTGA GCCTTGTGAA GTCGGGCAGT CCCACAAAGA TGTGGACAAG 
GAGGCGATGA TGGAAGCAGG CTGGGACCCC TGCCTGCAGG CCCCCTTCCA CCTCACCCCG 
ACCCTGTACA GGACGCTGCG TAATCAAGGC AACCAGGGAG CACCGGCGGA GAGCCGAGAG 
GTGCTGCAAG ACACGGTCAA CCTCCTTTTC AACCATCCCA GGCAGAGGAA TGCCTCCCGG 
GAGAACCTGA ACCTTCCCGA GCCCCAGCCT GCCACAGGCC AGCCACGTTC CAGGCCTCTG 
AAGGTTGCAG GCAGCCCCAC AGGGAGGCTG GCTGGAGACC AGGGCAGTGA GGAAGCCCCA 
CAGAGGCCAC CAGCCTCCTC TGCAACCCTG AGACGGCAGC GACATCTCAA TGGCAAAGTG 
TCCCCTGAGA AAGAATCAGG GCCCCGTCAG ATCCTGCGGA GCCTGGTCCG GCTGTCTGTG 
GCTGCCTTCG CCGAGCGGAA CCCCGTGGAG GAGCTCACTG TGGATTCTCC TCCTGTTCAG 
CAAATCTCCC AGCTGCTGTC CTTGCTGCAT CAGGGCCAAT TCCAGCCCAA ACCAAACCAC 
CGAGGAAATA AGTACTTGGC CAAGCCAGGA GGCAGCAGGA GTGCAATCCC AGACACAGAT 
GGCCCAAGTG CAAGGGCTGG AGGCCAGACA GACCCAGAAC AGGAGGAAGG GCCTTTGGAT 
CCTGAAGAGG ACCTCTCTGT GAAGCAACTG CTAGAAGAAG AGCTGTCAAG TCTGCTGGAC 
CCCAGCACAG GTCTGGCCCT GGACCGGCTG AGCGCCCCTG ACCCGGCCTG GATGGCGAGA 
CTCTCTTTGC CCCTCACCAC CAACTACCGT GACAATGTGA TCTCCCCGGA TGCTGCAGCC 
ACGGAGGAGC CAAGGACCTT CCAGACGTTC GGCAAGGCAG AGGCACCAGA GCTGAGCCCA 
ACAGGCACGA GGCTGGCCAG CACCTTTGTC TCGGAGATGA GCTCACTGCT GGAGATGCTG 
CTGGAACAGC GCTCCAGCAT GCCCGTGGAG GCCGCCTCCG AGGCGCTGCG GCGGCTCTCG 
GTCTGCGGGA GGACCCTCAG TTTAGACTTG GCCACCAGTG CAGCCTCAGG CATGAAAGTG 
CAAGGGGACC CAGGTGGAAA GACGGGGACT GAGGGCAAGA GCAGAGGCAG CAGCAGCAGC 
AGCAGGTGCC TGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PCDH12 ( XM_024446106.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_024301874.1 Homo sapiens protocadherin 12 (PCDH12), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu08561
Clone ID Related Accession (Same CDS sequence)	NM_016580.3 , NM_016580.4 , XM_024446106.1
Accession Version	XM_024446106.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3555bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	protocadherin-12 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000005.10) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGATGCAAC TTCTGCAACT TCTGCTGGGG CTTTTGGGGC CAGGTGGCTA CTTATTTCTT 
TTAGGGGATT GTCAGGAGGT GACCACTCTC ACGGTGAAAT ACCAAGTGTC AGAGGAAGTG 
CCATCTGGTA CAGTGATCGG GAAGCTGTCC CAGGAACTGG GCCGGGAGGA GAGGCGGAGG 
CAAGCTGGGG CTGCCTTCCA GGTGTTGCAG CTGCCTCAGG CGCTCCCCAT TCAGGTGGAC 
TCTGAGGAAG GCTTGCTCAG CACAGGCAGG CGGCTGGATC GAGAGCAGCT GTGCCGACAG 
TGGGATCCCT GCCTGGTTTC CTTTGATGTG CTTGCCACAG GGGATTTGGC TCTGATCCAT 
GTGGAGATCC AAGTGCTGGA CATCAATGAC CACCAGCCAC GGTTTCCCAA AGGCGAGCAG 
GAGCTGGAAA TCTCTGAGAG CGCCTCTCTG CGAACCCGGA TCCCCCTGGA CAGAGCTCTT 
GACCCAGACA CAGGCCCTAA CACCCTGCAC ACCTACACTC TGTCTCCCAG TGAGCACTTT 
GCCTTGGATG TCATTGTGGG CCCTGATGAG ACCAAACATG CAGAACTCAT AGTGGTGAAG 
GAGCTGGACA GGGAAATCCA TTCATTTTTT GATCTGGTGT TAACTGCCTA TGACAATGGG 
AACCCCCCCA AGTCAGGTAC CAGCTTGGTC AAGGTCAACG TCTTGGACTC CAATGACAAT 
AGCCCTGCGT TTGCTGAGAG TTCACTGGCA CTGGAAATCC AAGAAGATGC TGCACCTGGT 
ACGCTTCTCA TAAAACTGAC CGCCACAGAC CCTGACCAAG GCCCCAATGG GGAGGTGGAG 
TTCTTCCTCA GTAAGCACAT GCCTCCAGAG GTGCTGGACA CCTTCAGTAT TGATGCCAAG 
ACAGGCCAGG TCATTCTGCG TCGACCTCTA GACTATGAAA AGAACCCTGC CTACGAGGTG 
GATGTTCAGG CAAGGGACCT GGGTCCCAAT CCTATCCCAG CCCATTGCAA AGTTCTCATC 
AAGGTTCTGG ATGTCAATGA CAACATCCCA AGCATCCACG TCACATGGGC CTCCCAGCCA 
TCACTGGTGT CAGAAGCTCT TCCCAAGGAC AGTTTTATTG CTCTTGTCAT GGCAGATGAC 
TTGGATTCAG GACACAATGG TTTGGTCCAC TGCTGGCTGA GCCAAGAGCT GGGCCACTTC 
AGGCTGAAAA GAACTAATGG CAACACATAC ATGTTGCTAA CCAATGCCAC ACTGGACAGA 
GAGCAGTGGC CCAAATATAC CCTCACTCTG TTAGCCCAAG ACCAAGGACT CCAGCCCTTA 
TCAGCCAAGA AACAGCTCAG CATTCAGATC AGTGACATCA ACGACAATGC ACCTGTGTTT 
GAGAAAAGCA GGTATGAAGT CTCCACGCGG GAAAACAACT TACCCTCTCT TCACCTCATT 
ACCATCAAGG CTCATGATGC AGACTTGGGC ATTAATGGAA AAGTCTCATA CCGCATCCAG 
GACTCCCCAG TTGCTCACTT AGTAGCTATT GACTCCAACA CAGGAGAGGT CACTGCTCAG 
AGGTCACTGA ACTATGAAGA GATGGCCGGC TTTGAGTTCC AGGTGATCGC AGAGGACAGC 
GGGCAACCCA TGCTTGCATC CAGTGTCTCT GTGTGGGTCA GCCTCTTGGA TGCCAATGAT 
AATGCCCCAG AGGTGGTCCA GCCTGTGCTC AGCGATGGAA AAGCCAGCCT CTCCGTGCTT 
GTGAATGCCT CCACAGGCCA CCTGCTGGTG CCCATCGAGA CTCCCAATGG CTTGGGCCCA 
GCGGGCACTG ACACACCTCC ACTGGCCACT CACAGCTCCC GGCCATTCCT TTTGACAACC 
ATTGTGGCAA GAGATGCAGA CTCGGGGGCA AATGGAGAGC CCCTCTACAG CATCCGCAGT 
GGAAATGAAG CCCACCTCTT CATCCTCAAC CCTCATACGG GGCAGCTGTT CGTCAATGTC 
ACCAATGCCA GCAGCCTCAT TGGGAGTGAG TGGGAGCTGG AGATAGTAGT AGAGGACCAG 
GGAAGCCCCC CCTTACAGAC CCGAGCCCTG TTGAGGGTCA TGTTTGTCAC CAGTGTGGAC 
CACCTGAGGG ACTCAGCCCG CAAGCCTGGG GCCTTGAGCA TGTCGATGCT GACGGTGATC 
TGCCTGGCTG TACTGTTGGG CATCTTCGGG TTGATCCTGG CTTTGTTCAT GTCCATCTGC 
CGGACAGAAA AGAAGGACAA CAGGGCCTAC AACTGTCGGG AGGCCGAGTC CACCTACCGC 
CAGCAGCCCA AGAGGCCCCA GAAACACATT CAGAAGGCAG ACATCCACCT CGTGCCTGTG 
CTCAGGGGTC AGGCAGGTGA GCCTTGTGAA GTCGGGCAGT CCCACAAAGA TGTGGACAAG 
GAGGCGATGA TGGAAGCAGG CTGGGACCCC TGCCTGCAGG CCCCCTTCCA CCTCACCCCG 
ACCCTGTACA GGACGCTGCG TAATCAAGGC AACCAGGGAG CACCGGCGGA GAGCCGAGAG 
GTGCTGCAAG ACACGGTCAA CCTCCTTTTC AACCATCCCA GGCAGAGGAA TGCCTCCCGG 
GAGAACCTGA ACCTTCCCGA GCCCCAGCCT GCCACAGGCC AGCCACGTTC CAGGCCTCTG 
AAGGTTGCAG GCAGCCCCAC AGGGAGGCTG GCTGGAGACC AGGGCAGTGA GGAAGCCCCA 
CAGAGGCCAC CAGCCTCCTC TGCAACCCTG AGACGGCAGC GACATCTCAA TGGCAAAGTG 
TCCCCTGAGA AAGAATCAGG GCCCCGTCAG ATCCTGCGGA GCCTGGTCCG GCTGTCTGTG 
GCTGCCTTCG CCGAGCGGAA CCCCGTGGAG GAGCTCACTG TGGATTCTCC TCCTGTTCAG 
CAAATCTCCC AGCTGCTGTC CTTGCTGCAT CAGGGCCAAT TCCAGCCCAA ACCAAACCAC 
CGAGGAAATA AGTACTTGGC CAAGCCAGGA GGCAGCAGGA GTGCAATCCC AGACACAGAT 
GGCCCAAGTG CAAGGGCTGG AGGCCAGACA GACCCAGAAC AGGAGGAAGG GCCTTTGGAT 
CCTGAAGAGG ACCTCTCTGT GAAGCAACTG CTAGAAGAAG AGCTGTCAAG TCTGCTGGAC 
CCCAGCACAG GTCTGGCCCT GGACCGGCTG AGCGCCCCTG ACCCGGCCTG GATGGCGAGA 
CTCTCTTTGC CCCTCACCAC CAACTACCGT GACAATGTGA TCTCCCCGGA TGCTGCAGCC 
ACGGAGGAGC CAAGGACCTT CCAGACGTTC GGCAAGGCAG AGGCACCAGA GCTGAGCCCA 
ACAGGCACGA GGCTGGCCAG CACCTTTGTC TCGGAGATGA GCTCACTGCT GGAGATGCTG 
CTGGAACAGC GCTCCAGCAT GCCCGTGGAG GCCGCCTCCG AGGCGCTGCG GCGGCTCTCG 
GTCTGCGGGA GGACCCTCAG TTTAGACTTG GCCACCAGTG CAGCCTCAGG CATGAAAGTG 
CAAGGGGACC CAGGTGGAAA GACGGGGACT GAGGGCAAGA GCAGAGGCAG CAGCAGCAGC 
AGCAGGTGCC TGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_024301874.1
CDS	502..4056
Translation	MMQLLQLLLGLLGPGGYLFLLGDCQEVTTLTVKYQVSEEVPSGTVIGKLSQELGREERRRQAGAAFQVLQLPQALPIQVDSEEGLLSTGRRLDREQLCRQWDPCLVSFDVLATGDLALIHVEIQVLDINDHQPRFPKGEQELEISESASLRTRIPLDRALDPDTGPNTLHTYTLSPSEHFALDVIVGPDETKHAELIVVKELDREIHSFFDLVLTAYDNGNPPKSGTSLVKVNVLDSNDNSPAFAESSLALEIQEDAAPGTLLIKLTATDPDQGPNGEVEFFLSKHMPPEVLDTFSIDAKTGQVILRRPLDYEKNPAYEVDVQARDLGPNPIPAHCKVLIKVLDVNDNIPSIHVTWASQPSLVSEALPKDSFIALVMADDLDSGHNGLVHCWLSQELGHFRLKRTNGNTYMLLTNATLDREQWPKYTLTLLAQDQGLQPLSAKKQLSIQISDINDNAPVFEKSRYEVSTRENNLPSLHLITIKAHDADLGINGKVSYRIQDSPVAHLVAIDSNTGEVTAQRSLNYEEMAGFEFQVIAEDSGQPMLASSVSVWVSLLDANDNAPEVVQPVLSDGKASLSVLVNASTGHLLVPIETPNGLGPAGTDTPPLATHSSRPFLLTTIVARDADSGANGEPLYSIRSGNEAHLFILNPHTGQLFVNVTNASSLIGSEWELEIVVEDQGSPPLQTRALLRVMFVTSVDHLRDSARKPGALSMSMLTVICLAVLLGIFGLILALFMSICRTEKKDNRAYNCREAESTYRQQPKRPQKHIQKADIHLVPVLRGQAGEPCEVGQSHKDVDKEAMMEAGWDPCLQAPFHLTPTLYRTLRNQGNQGAPAESREVLQDTVNLLFNHPRQRNASRENLNLPEPQPATGQPRSRPLKVAGSPTGRLAGDQGSEEAPQRPPASSATLRRQRHLNGKVSPEKESGPRQILRSLVRLSVAAFAERNPVEELTVDSPPVQQISQLLSLLHQGQFQPKPNHRGNKYLAKPGGSRSAIPDTDGPSARAGGQTDPEQEEGPLDPEEDLSVKQLLEEELSSLLDPSTGLALDRLSAPDPAWMARLSLPLTTNYRDNVISPDAAATEEPRTFQTFGKAEAPELSPTGTRLASTFVSEMSSLLEMLLEQRSSMPVEAASEALRRLSVCGRTLSLDLATSAASGMKVQGDPGGKTGTEGKSRGSSSSSRCL

Target ORF information:

RefSeq Version	XM_024446106.1
Organism	Homo sapiens(human)
Definition	Homo sapiens protocadherin 12 (PCDH12), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_024446106.1

ORF Insert Sequence:

ATGATGCAAC TTCTGCAACT TCTGCTGGGG CTTTTGGGGC CAGGTGGCTA CTTATTTCTT 
TTAGGGGATT GTCAGGAGGT GACCACTCTC ACGGTGAAAT ACCAAGTGTC AGAGGAAGTG 
CCATCTGGTA CAGTGATCGG GAAGCTGTCC CAGGAACTGG GCCGGGAGGA GAGGCGGAGG 
CAAGCTGGGG CTGCCTTCCA GGTGTTGCAG CTGCCTCAGG CGCTCCCCAT TCAGGTGGAC 
TCTGAGGAAG GCTTGCTCAG CACAGGCAGG CGGCTGGATC GAGAGCAGCT GTGCCGACAG 
TGGGATCCCT GCCTGGTTTC CTTTGATGTG CTTGCCACAG GGGATTTGGC TCTGATCCAT 
GTGGAGATCC AAGTGCTGGA CATCAATGAC CACCAGCCAC GGTTTCCCAA AGGCGAGCAG 
GAGCTGGAAA TCTCTGAGAG CGCCTCTCTG CGAACCCGGA TCCCCCTGGA CAGAGCTCTT 
GACCCAGACA CAGGCCCTAA CACCCTGCAC ACCTACACTC TGTCTCCCAG TGAGCACTTT 
GCCTTGGATG TCATTGTGGG CCCTGATGAG ACCAAACATG CAGAACTCAT AGTGGTGAAG 
GAGCTGGACA GGGAAATCCA TTCATTTTTT GATCTGGTGT TAACTGCCTA TGACAATGGG 
AACCCCCCCA AGTCAGGTAC CAGCTTGGTC AAGGTCAACG TCTTGGACTC CAATGACAAT 
AGCCCTGCGT TTGCTGAGAG TTCACTGGCA CTGGAAATCC AAGAAGATGC TGCACCTGGT 
ACGCTTCTCA TAAAACTGAC CGCCACAGAC CCTGACCAAG GCCCCAATGG GGAGGTGGAG 
TTCTTCCTCA GTAAGCACAT GCCTCCAGAG GTGCTGGACA CCTTCAGTAT TGATGCCAAG 
ACAGGCCAGG TCATTCTGCG TCGACCTCTA GACTATGAAA AGAACCCTGC CTACGAGGTG 
GATGTTCAGG CAAGGGACCT GGGTCCCAAT CCTATCCCAG CCCATTGCAA AGTTCTCATC 
AAGGTTCTGG ATGTCAATGA CAACATCCCA AGCATCCACG TCACATGGGC CTCCCAGCCA 
TCACTGGTGT CAGAAGCTCT TCCCAAGGAC AGTTTTATTG CTCTTGTCAT GGCAGATGAC 
TTGGATTCAG GACACAATGG TTTGGTCCAC TGCTGGCTGA GCCAAGAGCT GGGCCACTTC 
AGGCTGAAAA GAACTAATGG CAACACATAC ATGTTGCTAA CCAATGCCAC ACTGGACAGA 
GAGCAGTGGC CCAAATATAC CCTCACTCTG TTAGCCCAAG ACCAAGGACT CCAGCCCTTA 
TCAGCCAAGA AACAGCTCAG CATTCAGATC AGTGACATCA ACGACAATGC ACCTGTGTTT 
GAGAAAAGCA GGTATGAAGT CTCCACGCGG GAAAACAACT TACCCTCTCT TCACCTCATT 
ACCATCAAGG CTCATGATGC AGACTTGGGC ATTAATGGAA AAGTCTCATA CCGCATCCAG 
GACTCCCCAG TTGCTCACTT AGTAGCTATT GACTCCAACA CAGGAGAGGT CACTGCTCAG 
AGGTCACTGA ACTATGAAGA GATGGCCGGC TTTGAGTTCC AGGTGATCGC AGAGGACAGC 
GGGCAACCCA TGCTTGCATC CAGTGTCTCT GTGTGGGTCA GCCTCTTGGA TGCCAATGAT 
AATGCCCCAG AGGTGGTCCA GCCTGTGCTC AGCGATGGAA AAGCCAGCCT CTCCGTGCTT 
GTGAATGCCT CCACAGGCCA CCTGCTGGTG CCCATCGAGA CTCCCAATGG CTTGGGCCCA 
GCGGGCACTG ACACACCTCC ACTGGCCACT CACAGCTCCC GGCCATTCCT TTTGACAACC 
ATTGTGGCAA GAGATGCAGA CTCGGGGGCA AATGGAGAGC CCCTCTACAG CATCCGCAGT 
GGAAATGAAG CCCACCTCTT CATCCTCAAC CCTCATACGG GGCAGCTGTT CGTCAATGTC 
ACCAATGCCA GCAGCCTCAT TGGGAGTGAG TGGGAGCTGG AGATAGTAGT AGAGGACCAG 
GGAAGCCCCC CCTTACAGAC CCGAGCCCTG TTGAGGGTCA TGTTTGTCAC CAGTGTGGAC 
CACCTGAGGG ACTCAGCCCG CAAGCCTGGG GCCTTGAGCA TGTCGATGCT GACGGTGATC 
TGCCTGGCTG TACTGTTGGG CATCTTCGGG TTGATCCTGG CTTTGTTCAT GTCCATCTGC 
CGGACAGAAA AGAAGGACAA CAGGGCCTAC AACTGTCGGG AGGCCGAGTC CACCTACCGC 
CAGCAGCCCA AGAGGCCCCA GAAACACATT CAGAAGGCAG ACATCCACCT CGTGCCTGTG 
CTCAGGGGTC AGGCAGGTGA GCCTTGTGAA GTCGGGCAGT CCCACAAAGA TGTGGACAAG 
GAGGCGATGA TGGAAGCAGG CTGGGACCCC TGCCTGCAGG CCCCCTTCCA CCTCACCCCG 
ACCCTGTACA GGACGCTGCG TAATCAAGGC AACCAGGGAG CACCGGCGGA GAGCCGAGAG 
GTGCTGCAAG ACACGGTCAA CCTCCTTTTC AACCATCCCA GGCAGAGGAA TGCCTCCCGG 
GAGAACCTGA ACCTTCCCGA GCCCCAGCCT GCCACAGGCC AGCCACGTTC CAGGCCTCTG 
AAGGTTGCAG GCAGCCCCAC AGGGAGGCTG GCTGGAGACC AGGGCAGTGA GGAAGCCCCA 
CAGAGGCCAC CAGCCTCCTC TGCAACCCTG AGACGGCAGC GACATCTCAA TGGCAAAGTG 
TCCCCTGAGA AAGAATCAGG GCCCCGTCAG ATCCTGCGGA GCCTGGTCCG GCTGTCTGTG 
GCTGCCTTCG CCGAGCGGAA CCCCGTGGAG GAGCTCACTG TGGATTCTCC TCCTGTTCAG 
CAAATCTCCC AGCTGCTGTC CTTGCTGCAT CAGGGCCAAT TCCAGCCCAA ACCAAACCAC 
CGAGGAAATA AGTACTTGGC CAAGCCAGGA GGCAGCAGGA GTGCAATCCC AGACACAGAT 
GGCCCAAGTG CAAGGGCTGG AGGCCAGACA GACCCAGAAC AGGAGGAAGG GCCTTTGGAT 
CCTGAAGAGG ACCTCTCTGT GAAGCAACTG CTAGAAGAAG AGCTGTCAAG TCTGCTGGAC 
CCCAGCACAG GTCTGGCCCT GGACCGGCTG AGCGCCCCTG ACCCGGCCTG GATGGCGAGA 
CTCTCTTTGC CCCTCACCAC CAACTACCGT GACAATGTGA TCTCCCCGGA TGCTGCAGCC 
ACGGAGGAGC CAAGGACCTT CCAGACGTTC GGCAAGGCAG AGGCACCAGA GCTGAGCCCA 
ACAGGCACGA GGCTGGCCAG CACCTTTGTC TCGGAGATGA GCTCACTGCT GGAGATGCTG 
CTGGAACAGC GCTCCAGCAT GCCCGTGGAG GCCGCCTCCG AGGCGCTGCG GCGGCTCTCG 
GTCTGCGGGA GGACCCTCAG TTTAGACTTG GCCACCAGTG CAGCCTCAGG CATGAAAGTG 
CAAGGGGACC CAGGTGGAAA GACGGGGACT GAGGGCAAGA GCAGAGGCAG CAGCAGCAGC 
AGCAGGTGCC TGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Loss of function of PCDH12 underlies recessive microcephaly mimicking intrauterine infection.
Neurology86(21)2016-24(2016 May)
Aran A,Rosenfeld N,Jaron R,Renbaum P,Zuckerman S,Fridman H,Zeligson S,Segel R,Kohn Y,Kamal L,Kanaan M,Segev Y,Mazaki E,Rabinowitz R,Shen O,Lee M,Walsh T,King MC,Gulsuner S,Levy-Lahad E

Protocadherin-12 cleavage is a regulated process mediated by ADAM10 protein: evidence of shedding up-regulation in pre-eclampsia.
The Journal of biological chemistry286(17)15195-204(2011 Apr)
Bouillot S,Tillet E,Carmona G,Prandini MH,Gauchez AS,Hoffmann P,Alfaidy N,Cand F,Huber P

- Most Popular Services
  - 人工遺伝子合成& DNA合成-納期保証
- Services & Products

見積依頼

Eメール

japanmarket@genscript.com

電話

03-6811-6572

FAX

03-6811-6573
050-3174-7589(受注専用)

オンラインフォーム

オンライン注文

PCDH12 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Most Popular Services

Services & Products

見積依頼

Eメール

電話

FAX

オンラインフォーム

サポート

会社情報

サポート

会社情報