RXFP3 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	RXFP3
Entrez Gene ID	51289
Full Name	relaxin/insulin like family peptide receptor 3
Synonyms	GPCR135,RLN3R1,RXFPR3,SALPR
General protein information	Preferred Names relaxin/insulin like family peptide receptor 3 Names relaxin-3 receptor 1 G-protein coupled receptor GPCR135 G-protein coupled receptor SALPR RLN3 receptor 1 g protein-coupled receptor SALPR relaxin family peptide receptor 3 somatostatin and angiotensin-like peptide receptor
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 5 Map Location: 5p13.2
Disorder MIM:	609445

mRNA and Protein(s)

mRNA	Protein	Name
NM_016568.3	NP_057652.1	relaxin-3 receptor 1

Pathways from BioSystems

Homologies

Homo sapiens (human)	RXFP3	NP_057652.1
Danio rerio (zebrafish)	rxfp3	NP_001122260.1
Mus musculus (house mouse)	Rxfp3	NP_848832.1
Gallus gallus (chicken)	RXFP3	XP_004937231.1
Pan troglodytes (chimpanzee)	RXFP3	XP_526961.2
Xenopus tropicalis (tropical clawed frog)	rxfp3	XP_002941625.1
	RXFP3	XP_001087833.1
Canis lupus familiaris (dog)	RXFP3	XP_005619474.1
Bos taurus (cattle)	RXFP3	XP_005221682.1
Rattus norvegicus (Norway rat)	Rxfp3	NP_001008311.1

Gene Ontology
Bibliography

Related articles in PubMed

Expression and localisation of RXFP3 in human spermatozoa and impact of INSL7 on sperm functions.
Heidari S, Taromchi AH, Nejatbakhsh R, Shokri S
Andrologia(2017 Nov)

Hydrocarbon stapled B chain analogues of relaxin-3 retain biological activity.
Jayakody T, Marwari S, Lakshminarayanan R, Tan FC, Johannes CW, Dymock BW, Poulsen A, Herr DR, Dawe GS
Peptides8444-57(2016 Oct)

A negatively charged transmembrane aspartate residue controls activation of the relaxin-3 receptor RXFP3.
Liu Y, Zhang L, Shao XX, Hu MJ, Liu YL, Xu ZG, Guo ZY
Archives of biochemistry and biophysics604113-20(2016 Aug)

Mechanism for insulin-like peptide 5 distinguishing the homologous relaxin family peptide receptor 3 and 4.
Hu MJ, Shao XX, Wang JH, Wei D, Guo YQ, Liu YL, Xu ZG, Guo ZY
Scientific reports629648(2016 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

the negatively charged transmembrane aspartate residue controls activation of the relaxin-3 receptor RXFP3
Title: A negatively charged transmembrane aspartate residue controls activation of the relaxin-3 receptor RXFP3.

we demonstrated distinct patterns of signalling for H3 and H2 relaxin and R3(BDelta23-27)R/I5 at the RXFP3 receptor
Title: Signalling profiles of H3 relaxin, H2 relaxin and R3(B?23-27)R/I5 acting at the relaxin family peptide receptor 3 (RXFP3).

Glu141 and Asp145 of the RXFP3 interact with the highly conserved arginine residues of relaxin-3.
Title: The highly conserved negatively charged Glu141 and Asp145 of the G-protein-coupled receptor RXFP3 interact with the highly conserved positively charged arginine residues of relaxin-3.

demonstrate the existence of an allosteric site for modulation of RXFP3
Title: In vitro pharmacological characterization of RXFP3 allosterism: an example of probe dependency.

Methylation status of CIDEA, HAAO and RXFP3 had significant association with microsatellite instability in endometrial tumors.
Title: Promoter hypermethylation of CIDEA, HAAO and RXFP3 associated with microsatellite instability in endometrial carcinomas.

The following RXFP3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the RXFP3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu10422	NM_016568.3 Latest version!	Homo sapiens relaxin family peptide receptor 3 (RXFP3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

RXFP3 ( NM_016568.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_057652.1 Homo sapiens relaxin family peptide receptor 3 (RXFP3), mRNA.

Price & Availability↑

CloneID	OHu10422
Clone ID Related Accession (Same CDS sequence)	NM_016568.3
Accession Version	NM_016568.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1410bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-03
Organism	Homo sapiens(human)
Product	relaxin-3 receptor 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from D88437.1, BC113438.1 and AC139777.3. On Mar 31, 2010 this sequence version replaced NM_016568.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000330120.5/ ENSP00000328708.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##

ATGCAGATGG CCGATGCAGC CACGATAGCC ACCATGAATA AGGCAGCAGG CGGGGACAAG 
CTAGCAGAAC TCTTCAGTCT GGTCCCGGAC CTTCTGGAGG CGGCCAACAC GAGTGGTAAC 
GCGTCGCTGC AGCTTCCGGA CTTGTGGTGG GAGCTGGGGC TGGAGTTGCC GGACGGCGCG 
CCGCCAGGAC ATCCCCCGGG CAGCGGCGGG GCAGAGAGCG CGGACACAGA GGCCCGGGTG 
CGGATTCTCA TCAGCGTGGT GTACTGGGTG GTGTGCGCCC TGGGGTTGGC GGGCAACCTG 
CTGGTTCTCT ACCTGATGAA GAGCATGCAG GGCTGGCGCA AGTCCTCTAT CAACCTCTTC 
GTCACCAACC TGGCGCTGAC GGACTTTCAG TTTGTGCTCA CCCTGCCCTT CTGGGCGGTG 
GAGAACGCTC TTGACTTCAA ATGGCCCTTC GGCAAGGCCA TGTGTAAGAT CGTGTCCATG 
GTGACGTCCA TGAACATGTA CGCCAGCGTG TTCTTCCTCA CTGCCATGAG TGTGACGCGC 
TACCATTCGG TGGCCTCGGC TCTGAAGAGC CACCGGACCC GAGGACACGG CCGGGGCGAC 
TGCTGCGGCC GGAGCCTGGG GGACAGCTGC TGCTTCTCGG CCAAGGCGCT GTGTGTGTGG 
ATCTGGGCTT TGGCCGCGCT GGCCTCGCTG CCCAGTGCCA TTTTCTCCAC CACGGTCAAG 
GTGATGGGCG AGGAGCTGTG CCTGGTGCGT TTCCCGGACA AGTTGCTGGG CCGCGACAGG 
CAGTTCTGGC TGGGCCTCTA CCACTCGCAG AAGGTGCTGC TGGGCTTCGT GCTGCCGCTG 
GGCATCATTA TCTTGTGCTA CCTGCTGCTG GTGCGCTTCA TCGCCGACCG CCGCGCGGCG 
GGGACCAAAG GAGGGGCCGC GGTAGCCGGA GGACGCCCGA CCGGAGCCAG CGCCCGGAGA 
CTGTCGAAGG TCACCAAATC AGTGACCATC GTTGTCCTGT CCTTCTTCCT GTGTTGGCTG 
CCCAACCAGG CGCTCACCAC CTGGAGCATC CTCATCAAGT TCAACGCGGT GCCCTTCAGC 
CAGGAGTATT TCCTGTGCCA GGTATACGCG TTCCCTGTGA GCGTGTGCCT AGCGCACTCC 
AACAGCTGCC TCAACCCCGT CCTCTACTGC CTCGTGCGCC GCGAGTTCCG CAAGGCGCTC 
AAGAGCCTGC TGTGGCGCAT CGCGTCTCCT TCGATCACCA GCATGCGCCC CTTCACCGCC 
ACTACCAAGC CGGAGCACGA GGATCAGGGG CTGCAGGCCC CGGCGCCGCC CCACGCGGCC 
GCGGAGCCGG ACCTGCTCTA CTACCCACCT GGCGTCGTGG TCTACAGCGG GGGGCGCTAC 
GACCTGCTGC CCAGCAGCTC TGCCTACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_057652.1
CDS	356..1765
Translation	MQMADAATIATMNKAAGGDKLAELFSLVPDLLEAANTSGNASLQLPDLWWELGLELPDGAPPGHPPGSGGAESADTEARVRILISVVYWVVCALGLAGNLLVLYLMKSMQGWRKSSINLFVTNLALTDFQFVLTLPFWAVENALDFKWPFGKAMCKIVSMVTSMNMYASVFFLTAMSVTRYHSVASALKSHRTRGHGRGDCCGRSLGDSCCFSAKALCVWIWALAALASLPSAIFSTTVKVMGEELCLVRFPDKLLGRDRQFWLGLYHSQKVLLGFVLPLGIIILCYLLLVRFIADRRAAGTKGGAAVAGGRPTGASARRLSKVTKSVTIVVLSFFLCWLPNQALTTWSILIKFNAVPFSQEYFLCQVYAFPVSVCLAHSNSCLNPVLYCLVRREFRKALKSLLWRIASPSITSMRPFTATTKPEHEDQGLQAPAPPHAAAEPDLLYYPPGVVVYSGGRYDLLPSSSAY

Target ORF information:

RefSeq Version	NM_016568.3
Organism	Homo sapiens(human)
Definition	Homo sapiens relaxin family peptide receptor 3 (RXFP3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_016568.3

ORF Insert Sequence:

ATGCAGATGG CCGATGCAGC CACGATAGCC ACCATGAATA AGGCAGCAGG CGGGGACAAG 
CTAGCAGAAC TCTTCAGTCT GGTCCCGGAC CTTCTGGAGG CGGCCAACAC GAGTGGTAAC 
GCGTCGCTGC AGCTTCCGGA CTTGTGGTGG GAGCTGGGGC TGGAGTTGCC GGACGGCGCG 
CCGCCAGGAC ATCCCCCGGG CAGCGGCGGG GCAGAGAGCG CGGACACAGA GGCCCGGGTG 
CGGATTCTCA TCAGCGTGGT GTACTGGGTG GTGTGCGCCC TGGGGTTGGC GGGCAACCTG 
CTGGTTCTCT ACCTGATGAA GAGCATGCAG GGCTGGCGCA AGTCCTCTAT CAACCTCTTC 
GTCACCAACC TGGCGCTGAC GGACTTTCAG TTTGTGCTCA CCCTGCCCTT CTGGGCGGTG 
GAGAACGCTC TTGACTTCAA ATGGCCCTTC GGCAAGGCCA TGTGTAAGAT CGTGTCCATG 
GTGACGTCCA TGAACATGTA CGCCAGCGTG TTCTTCCTCA CTGCCATGAG TGTGACGCGC 
TACCATTCGG TGGCCTCGGC TCTGAAGAGC CACCGGACCC GAGGACACGG CCGGGGCGAC 
TGCTGCGGCC GGAGCCTGGG GGACAGCTGC TGCTTCTCGG CCAAGGCGCT GTGTGTGTGG 
ATCTGGGCTT TGGCCGCGCT GGCCTCGCTG CCCAGTGCCA TTTTCTCCAC CACGGTCAAG 
GTGATGGGCG AGGAGCTGTG CCTGGTGCGT TTCCCGGACA AGTTGCTGGG CCGCGACAGG 
CAGTTCTGGC TGGGCCTCTA CCACTCGCAG AAGGTGCTGC TGGGCTTCGT GCTGCCGCTG 
GGCATCATTA TCTTGTGCTA CCTGCTGCTG GTGCGCTTCA TCGCCGACCG CCGCGCGGCG 
GGGACCAAAG GAGGGGCCGC GGTAGCCGGA GGACGCCCGA CCGGAGCCAG CGCCCGGAGA 
CTGTCGAAGG TCACCAAATC AGTGACCATC GTTGTCCTGT CCTTCTTCCT GTGTTGGCTG 
CCCAACCAGG CGCTCACCAC CTGGAGCATC CTCATCAAGT TCAACGCGGT GCCCTTCAGC 
CAGGAGTATT TCCTGTGCCA GGTATACGCG TTCCCTGTGA GCGTGTGCCT AGCGCACTCC 
AACAGCTGCC TCAACCCCGT CCTCTACTGC CTCGTGCGCC GCGAGTTCCG CAAGGCGCTC 
AAGAGCCTGC TGTGGCGCAT CGCGTCTCCT TCGATCACCA GCATGCGCCC CTTCACCGCC 
ACTACCAAGC CGGAGCACGA GGATCAGGGG CTGCAGGCCC CGGCGCCGCC CCACGCGGCC 
GCGGAGCCGG ACCTGCTCTA CTACCCACCT GGCGTCGTGG TCTACAGCGG GGGGCGCTAC 
GACCTGCTGC CCAGCAGCTC TGCCTACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Expression and localisation of RXFP3 in human spermatozoa and impact of INSL7 on sperm functions.
Andrologia(2017 Nov)
Heidari S,Taromchi AH,Nejatbakhsh R,Shokri S

Hydrocarbon stapled B chain analogues of relaxin-3 retain biological activity.
Peptides8444-57(2016 Oct)
Jayakody T,Marwari S,Lakshminarayanan R,Tan FC,Johannes CW,Dymock BW,Poulsen A,Herr DR,Dawe GS

A negatively charged transmembrane aspartate residue controls activation of the relaxin-3 receptor RXFP3.
Archives of biochemistry and biophysics604113-20(2016 Aug)
Liu Y,Zhang L,Shao XX,Hu MJ,Liu YL,Xu ZG,Guo ZY

Mechanism for insulin-like peptide 5 distinguishing the homologous relaxin family peptide receptor 3 and 4.
Scientific reports629648(2016 Jul)
Hu MJ,Shao XX,Wang JH,Wei D,Guo YQ,Liu YL,Xu ZG,Guo ZY