IER5 cDNA ORF clone, Homo sapiens(human)

IER5 as a promising predictive marker promotes irradiation-induced apoptosis in cervical cancer tissues from patients undergoing chemoradiotherapy.
Liu Y, Tian M, Zhao H, He Y, Li F, Li X, Yu X, Ding K, Zhou P, Wu Y
Oncotarget8(22)36438-36448(2017 May)

IER5 is involved in DNA Double-Strand Breaks Repair in Association with PAPR1 in Hela Cells.
Yu XP, Wu YM, Liu Y, Tian M, Wang JD, Ding KK, Ma T, Zhou PK
International journal of medical sciences14(12)1292-1300(2017)

Transcriptional regulation of IER5 in response to radiation in HepG2.
Yang C, Yin L, Zhou P, Liu X, Yang M, Yang F, Jiang H, Ding K
Cancer gene therapy23(2-3)61-5(2016 Feb-Mar)

IER5 generates a novel hypo-phosphorylated active form of HSF1 and contributes to tumorigenesis.
Asano Y, Kawase T, Okabe A, Tsutsumi S, Ichikawa H, Tatebe S, Kitabayashi I, Tashiro F, Namiki H, Kondo T, Semba K, Aburatani H, Taya Y, Nakagama H, Ohki R
Scientific reports619174(2016 Jan)

Immediate-early response 5 (IER5) interacts with protein phosphatase 2A and regulates the phosphorylation of ribosomal protein S6 kinase and heat shock factor 1.
Kawabata S, Ishita Y, Ishikawa Y, Sakurai H
FEBS letters589(23)3679-85(2015 Nov)

Authors propose the GCF regulated transcriptional activity, at least in part, contributed to the upregulation of IER5 on radiation in HepG2 cells. The present findings provide insights into understanding the regulatory mechanisms of IER5.
Title: Transcriptional regulation of IER5 in response to radiation in HepG2.

These results reveal the existence of a novel IER5-mediated cancer regulation pathway that is responsible for the activation of HSF1 observed in various cancers.
Title: IER5 generates a novel hypo-phosphorylated active form of HSF1 and contributes to tumorigenesis.

IER5 functions as a positive feedback regulator of HSF1 and that this process involves PP2A/B55 and HSF1 dephosphorylation.
Title: HSF1 transcriptional activity is modulated by IER5 and PP2A/B55.

These observations suggest that HSF1-mediated IER5 expression is involved in the expression of chaperone genes and in recovery from thermal stress.
Title: Heat-induced expression of the immediate-early gene IER5 and its involvement in the proliferation of heat-shocked cells.

Transcriptional repression mediated by IER5 regulates Cdc25B expression levels via the release of NF-YB and p300 in acute myeloid leukemia.
Title: Transcriptional repression of Cdc25B by IER5 inhibits the proliferation of leukemic progenitor cells through NF-YB and p300 in acute myeloid leukemia.