KLF3 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	KLF3
Entrez Gene ID	51274
Full Name	Kruppel like factor 3
Synonyms	BKLF
General protein information	Preferred Names Kruppel like factor 3 Names Krueppel-like factor 3 CACCC-box-binding protein BKLF Kruppel-like factor 3 (basic) TEF-2 basic Kruppel-like factor basic krueppel-like factor basic kruppel like factor transcript ch138
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 4 Map Location: 4p14
Disorder MIM:	609392

mRNA and Protein(s)

mRNA	Protein	Name
NM_016531.6	NP_057615.3	Krueppel-like factor 3
XM_017008279.1	XP_016863768.1	Krueppel-like factor 3 isoform X1
XM_017008279.2	XP_016863768.1	Krueppel-like factor 3 isoform X1
NM_016531.5	NP_057615.3	Krueppel-like factor 3

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	KLF3	XP_545954.3
Pan troglodytes (chimpanzee)	KLF3	XP_517146.2
Bos taurus (cattle)	KLF3	NP_001192907.1
Xenopus tropicalis (tropical clawed frog)	klf3	XP_002938694.1
Homo sapiens (human)	KLF3	NP_057615.3
Mus musculus (house mouse)	Klf3	NP_032479.1
Gallus gallus (chicken)	KLF3	XP_427367.3
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP010520	XP_314495.3
	KLF3	XP_001088190.1
Rattus norvegicus (Norway rat)	Klf3	NP_001099212.1

Gene Ontology
Bibliography

Related articles in PubMed

RNA sequencing analysis reveals protective role of kruppel-like factor 3 in colorectal cancer.
Wang X, Jiang Z, Zhang Y, Wang X, Liu L, Fan Z
Oncotarget8(13)21984-21993(2017 Mar)

Pooled-matrix protein interaction screens using Barcode Fusion Genetics.
Yachie N, Petsalaki E, Mellor JC, Weile J, Jacob Y, Verby M, Ozturk SB, Li S, Cote AG, Mosca R, Knapp JJ, Ko M, Yu A, Gebbia M, Sahni N, Yi S, Tyagi T, Sheykhkarimli D, Roth JF, Wong C, Musa L, Snider J, Liu YC, Yu H, Braun P, Stagljar I, Hao T, Calderwood MA, Pelletier L, Aloy P, Hill DE, Vidal M, Roth FP
Molecular systems biology12(4)863(2016 Apr)

Epigenetic silencing of Kruppel like factor-3 increases expression of pro-metastatic miR-182.
Sachdeva M, Dodd RD, Huang Z, Grenier C, Ma Y, Lev DC, Cardona DM, Murphy SK, Kirsch DG
Cancer letters369(1)202-11(2015 Dec)

The role of epigenetics in the endothelial cell shear stress response and atherosclerosis.
Dunn J, Simmons R, Thabet S, Jo H
The international journal of biochemistry & cell biology67167-76(2015 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Low KLF3 expression is associated with colorectal cancer.
Title: RNA sequencing analysis reveals protective role of kruppel-like factor 3 in colorectal cancer.

Klf-3 expression is downregulated in human metastatic sarcomas, and Klf-3 levels negatively correlate with miR-182 expression.
Title: Epigenetic silencing of Kruppel like factor-3 increases expression of pro-metastatic miR-182.

Among the mechanosensitive genes, the two transcription factors, HoxA5 and Klf3, contain cAMP-response-elements methylation of which could serve as a mechanosensitive master switch in gene expression in atherosclerosis. (Review)
Title: The role of epigenetics in the endothelial cell shear stress response and atherosclerosis.

A feedback loop consisting of microRNA 23a/27a and the beta-like globin suppressors KLF3 and SP1 regulates globin gene expression.
Title: A feedback loop consisting of microRNA 23a/27a and the ?-like globin suppressors KLF3 and SP1 regulates globin gene expression.

B cell differentiation is significantly impaired in the bone marrow, spleen, and peritoneal cavity of Klf3 null mice; the defects are cell autonomous.
Title: Impaired B cell development in the absence of Kr?ppel-like factor 3.

The following KLF3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the KLF3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu25447	NM_016531.6 Latest version!	Homo sapiens Kruppel like factor 3 (KLF3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
OHu38569	XM_017008279.2 Latest version!	Homo sapiens Kruppel like factor 3 (KLF3), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
View Old Accession Versions >>
OHu38569	XM_017008279.1	Homo sapiens Kruppel-like factor 3 (basic) (KLF3), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
OHu25447	NM_016531.5	Homo sapiens Kruppel like factor 3 (KLF3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

KLF3 ( NM_016531.6 ) cDNA ORF clone, Homo sapiens(human) -> NP_057615.3 Homo sapiens Kruppel like factor 3 (KLF3), mRNA.

Price & Availability↑

CloneID	OHu25447
Clone ID Related Accession (Same CDS sequence)	NM_016531.6 , NM_016531.5
Accession Version	NM_016531.6 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1038bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-16
Organism	Homo sapiens(human)
Product	Krueppel-like factor 3
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DB246277.1, AF285837.1, AC021860.6 and BU689914.1. On Nov 23, 2018 this sequence version replaced NM_016531.5. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803611.185490.1, SRR1803612.216210.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000261438.10/ ENSP00000261438.5 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGCTCATGT TTGACCCAGT TCCTGTCAAG CAAGAGGCCA TGGACCCTGT CTCAGTGTCA 
TACCCATCTA ATTACATGGA ATCCATGAAG CCTAACAAGT ATGGGGTCAT CTACTCCACA 
CCATTGCCTG AGAAGTTCTT TCAGACCCCA GAAGGTCTGT CGCACGGAAT ACAGATGGAG 
CCAGTGGACC TCACGGTGAA CAAGCGGAGT TCACCCCCTT CGGCTGGGAA TTCGCCCTCC 
TCTCTGAAGT TCCCGTCCTC ACACCGGAGA GCCTCGCCTG GGTTGAGCAT GCCTTCTTCC 
AGCCCACCGA TAAAAAAATA CTCACCCCCT TCTCCAGGCG TGCAGCCCTT CGGCGTGCCG 
CTGTCCATGC CACCAGTGAT GGCAGCTGCC CTCTCGCGGC ATGGAATACG GAGCCCGGGG 
ATCCTGCCCG TCATCCAGCC GGTGGTGGTG CAGCCCGTCC CCTTTATGTA CACAAGTCAC 
CTCCAGCAGC CTCTCATGGT CTCCTTATCG GAGGAGATGG AAAATTCCAG TAGTAGCATG 
CAAGTACCTG TAATTGAATC ATATGAGAAG CCTATATCAC AGAAAAAAAT TAAAATAGAA 
CCTGGGATCG AACCACAGAG GACAGATTAT TATCCTGAAG AAATGTCACC CCCCTTAATG 
AACTCAGTGT CCCCCCCGCA AGCATTGTTG CAAGAGAATC ACCCTTCGGT CATCGTGCAG 
CCTGGGAAGA GACCTTTACC TGTGGAATCC CCGGATACTC AAAGGAAGCG GAGGATACAC 
AGATGTGATT ATGATGGATG CAACAAAGTG TACACTAAAA GCTCCCACTT GAAAGCACAC 
AGAAGAACAC ACACAGGAGA AAAACCCTAC AAATGTACAT GGGAAGGGTG CACATGGAAG 
TTTGCTCGGT CTGATGAACT AACAAGACAT TTCCGAAAAC ATACTGGAAT CAAACCTTTC 
CAGTGCCCGG ACTGTGACCG CAGCTTCTCC CGTTCTGACC ATCTTGCCCT CCATAGGAAA 
CGCCACATGC TAGTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_057615.3
CDS	303..1340
Translation	MLMFDPVPVKQEAMDPVSVSYPSNYMESMKPNKYGVIYSTPLPEKFFQTPEGLSHGIQMEPVDLTVNKRSSPPSAGNSPSSLKFPSSHRRASPGLSMPSSSPPIKKYSPPSPGVQPFGVPLSMPPVMAAALSRHGIRSPGILPVIQPVVVQPVPFMYTSHLQQPLMVSLSEEMENSSSSMQVPVIESYEKPISQKKIKIEPGIEPQRTDYYPEEMSPPLMNSVSPPQALLQENHPSVIVQPGKRPLPVESPDTQRKRRIHRCDYDGCNKVYTKSSHLKAHRRTHTGEKPYKCTWEGCTWKFARSDELTRHFRKHTGIKPFQCPDCDRSFSRSDHLALHRKRHMLV

Target ORF information:

RefSeq Version	NM_016531.6
Organism	Homo sapiens(human)
Definition	Homo sapiens Kruppel like factor 3 (KLF3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_016531.6

ORF Insert Sequence:

ATGCTCATGT TTGACCCAGT TCCTGTCAAG CAAGAGGCCA TGGACCCTGT CTCAGTGTCA 
TACCCATCTA ATTACATGGA ATCCATGAAG CCTAACAAGT ATGGGGTCAT CTACTCCACA 
CCATTGCCTG AGAAGTTCTT TCAGACCCCA GAAGGTCTGT CGCACGGAAT ACAGATGGAG 
CCAGTGGACC TCACGGTGAA CAAGCGGAGT TCACCCCCTT CGGCTGGGAA TTCGCCCTCC 
TCTCTGAAGT TCCCGTCCTC ACACCGGAGA GCCTCGCCTG GGTTGAGCAT GCCTTCTTCC 
AGCCCACCGA TAAAAAAATA CTCACCCCCT TCTCCAGGCG TGCAGCCCTT CGGCGTGCCG 
CTGTCCATGC CACCAGTGAT GGCAGCTGCC CTCTCGCGGC ATGGAATACG GAGCCCGGGG 
ATCCTGCCCG TCATCCAGCC GGTGGTGGTG CAGCCCGTCC CCTTTATGTA CACAAGTCAC 
CTCCAGCAGC CTCTCATGGT CTCCTTATCG GAGGAGATGG AAAATTCCAG TAGTAGCATG 
CAAGTACCTG TAATTGAATC ATATGAGAAG CCTATATCAC AGAAAAAAAT TAAAATAGAA 
CCTGGGATCG AACCACAGAG GACAGATTAT TATCCTGAAG AAATGTCACC CCCCTTAATG 
AACTCAGTGT CCCCCCCGCA AGCATTGTTG CAAGAGAATC ACCCTTCGGT CATCGTGCAG 
CCTGGGAAGA GACCTTTACC TGTGGAATCC CCGGATACTC AAAGGAAGCG GAGGATACAC 
AGATGTGATT ATGATGGATG CAACAAAGTG TACACTAAAA GCTCCCACTT GAAAGCACAC 
AGAAGAACAC ACACAGGAGA AAAACCCTAC AAATGTACAT GGGAAGGGTG CACATGGAAG 
TTTGCTCGGT CTGATGAACT AACAAGACAT TTCCGAAAAC ATACTGGAAT CAAACCTTTC 
CAGTGCCCGG ACTGTGACCG CAGCTTCTCC CGTTCTGACC ATCTTGCCCT CCATAGGAAA 
CGCCACATGC TAGTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

KLF3 ( NM_016531.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_057615.3 Homo sapiens Kruppel like factor 3 (KLF3), mRNA.

Price & Availability↑

CloneID	OHu25447
Clone ID Related Accession (Same CDS sequence)	NM_016531.6 , NM_016531.5
Accession Version	NM_016531.5	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1038bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-29
Organism	Homo sapiens(human)
Product	Krueppel-like factor 3
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DB246277.1, AF285837.1, AC021860.6 and BU689914.1. On Aug 22, 2007 this sequence version replaced NM_016531.4. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660809.142275.1, SRR1803612.216210.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCTCATGT TTGACCCAGT TCCTGTCAAG CAAGAGGCCA TGGACCCTGT CTCAGTGTCA 
TACCCATCTA ATTACATGGA ATCCATGAAG CCTAACAAGT ATGGGGTCAT CTACTCCACA 
CCATTGCCTG AGAAGTTCTT TCAGACCCCA GAAGGTCTGT CGCACGGAAT ACAGATGGAG 
CCAGTGGACC TCACGGTGAA CAAGCGGAGT TCACCCCCTT CGGCTGGGAA TTCGCCCTCC 
TCTCTGAAGT TCCCGTCCTC ACACCGGAGA GCCTCGCCTG GGTTGAGCAT GCCTTCTTCC 
AGCCCACCGA TAAAAAAATA CTCACCCCCT TCTCCAGGCG TGCAGCCCTT CGGCGTGCCG 
CTGTCCATGC CACCAGTGAT GGCAGCTGCC CTCTCGCGGC ATGGAATACG GAGCCCGGGG 
ATCCTGCCCG TCATCCAGCC GGTGGTGGTG CAGCCCGTCC CCTTTATGTA CACAAGTCAC 
CTCCAGCAGC CTCTCATGGT CTCCTTATCG GAGGAGATGG AAAATTCCAG TAGTAGCATG 
CAAGTACCTG TAATTGAATC ATATGAGAAG CCTATATCAC AGAAAAAAAT TAAAATAGAA 
CCTGGGATCG AACCACAGAG GACAGATTAT TATCCTGAAG AAATGTCACC CCCCTTAATG 
AACTCAGTGT CCCCCCCGCA AGCATTGTTG CAAGAGAATC ACCCTTCGGT CATCGTGCAG 
CCTGGGAAGA GACCTTTACC TGTGGAATCC CCGGATACTC AAAGGAAGCG GAGGATACAC 
AGATGTGATT ATGATGGATG CAACAAAGTG TACACTAAAA GCTCCCACTT GAAAGCACAC 
AGAAGAACAC ACACAGGAGA AAAACCCTAC AAATGTACAT GGGAAGGGTG CACATGGAAG 
TTTGCTCGGT CTGATGAACT AACAAGACAT TTCCGAAAAC ATACTGGAAT CAAACCTTTC 
CAGTGCCCGG ACTGTGACCG CAGCTTCTCC CGTTCTGACC ATCTTGCCCT CCATAGGAAA 
CGCCACATGC TAGTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_057615.3
CDS	333..1370
Translation	MLMFDPVPVKQEAMDPVSVSYPSNYMESMKPNKYGVIYSTPLPEKFFQTPEGLSHGIQMEPVDLTVNKRSSPPSAGNSPSSLKFPSSHRRASPGLSMPSSSPPIKKYSPPSPGVQPFGVPLSMPPVMAAALSRHGIRSPGILPVIQPVVVQPVPFMYTSHLQQPLMVSLSEEMENSSSSMQVPVIESYEKPISQKKIKIEPGIEPQRTDYYPEEMSPPLMNSVSPPQALLQENHPSVIVQPGKRPLPVESPDTQRKRRIHRCDYDGCNKVYTKSSHLKAHRRTHTGEKPYKCTWEGCTWKFARSDELTRHFRKHTGIKPFQCPDCDRSFSRSDHLALHRKRHMLV

Target ORF information:

RefSeq Version	NM_016531.5
Organism	Homo sapiens(human)
Definition	Homo sapiens Kruppel like factor 3 (KLF3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_016531.5

ORF Insert Sequence:

ATGCTCATGT TTGACCCAGT TCCTGTCAAG CAAGAGGCCA TGGACCCTGT CTCAGTGTCA 
TACCCATCTA ATTACATGGA ATCCATGAAG CCTAACAAGT ATGGGGTCAT CTACTCCACA 
CCATTGCCTG AGAAGTTCTT TCAGACCCCA GAAGGTCTGT CGCACGGAAT ACAGATGGAG 
CCAGTGGACC TCACGGTGAA CAAGCGGAGT TCACCCCCTT CGGCTGGGAA TTCGCCCTCC 
TCTCTGAAGT TCCCGTCCTC ACACCGGAGA GCCTCGCCTG GGTTGAGCAT GCCTTCTTCC 
AGCCCACCGA TAAAAAAATA CTCACCCCCT TCTCCAGGCG TGCAGCCCTT CGGCGTGCCG 
CTGTCCATGC CACCAGTGAT GGCAGCTGCC CTCTCGCGGC ATGGAATACG GAGCCCGGGG 
ATCCTGCCCG TCATCCAGCC GGTGGTGGTG CAGCCCGTCC CCTTTATGTA CACAAGTCAC 
CTCCAGCAGC CTCTCATGGT CTCCTTATCG GAGGAGATGG AAAATTCCAG TAGTAGCATG 
CAAGTACCTG TAATTGAATC ATATGAGAAG CCTATATCAC AGAAAAAAAT TAAAATAGAA 
CCTGGGATCG AACCACAGAG GACAGATTAT TATCCTGAAG AAATGTCACC CCCCTTAATG 
AACTCAGTGT CCCCCCCGCA AGCATTGTTG CAAGAGAATC ACCCTTCGGT CATCGTGCAG 
CCTGGGAAGA GACCTTTACC TGTGGAATCC CCGGATACTC AAAGGAAGCG GAGGATACAC 
AGATGTGATT ATGATGGATG CAACAAAGTG TACACTAAAA GCTCCCACTT GAAAGCACAC 
AGAAGAACAC ACACAGGAGA AAAACCCTAC AAATGTACAT GGGAAGGGTG CACATGGAAG 
TTTGCTCGGT CTGATGAACT AACAAGACAT TTCCGAAAAC ATACTGGAAT CAAACCTTTC 
CAGTGCCCGG ACTGTGACCG CAGCTTCTCC CGTTCTGACC ATCTTGCCCT CCATAGGAAA 
CGCCACATGC TAGTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

KLF3 ( XM_017008279.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016863768.1 Homo sapiens Kruppel-like factor 3 (basic) (KLF3), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu38569
Clone ID Related Accession (Same CDS sequence)	XM_017008279.1 , XM_017008279.2
Accession Version	XM_017008279.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 963bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	Krueppel-like factor 3 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000004.12) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGAATCCA TGAAGCCTAA CAAGTATGGG GTCATCTACT CCACACCATT GCCTGAGAAG 
TTCTTTCAGA CCCCAGAAGG TCTGTCGCAC GGAATACAGA TGGAGCCAGT GGACCTCACG 
GTGAACAAGC GGAGTTCACC CCCTTCGGCT GGGAATTCGC CCTCCTCTCT GAAGTTCCCG 
TCCTCACACC GGAGAGCCTC GCCTGGGTTG AGCATGCCTT CTTCCAGCCC ACCGATAAAA 
AAATACTCAC CCCCTTCTCC AGGCGTGCAG CCCTTCGGCG TGCCGCTGTC CATGCCACCA 
GTGATGGCAG CTGCCCTCTC GCGGCATGGA ATACGGAGCC CGGGGATCCT GCCCGTCATC 
CAGCCGGTGG TGGTGCAGCC CGTCCCCTTT ATGTACACAA GTCACCTCCA GCAGCCTCTC 
ATGGTCTCCT TATCGGAGGA GATGGAAAAT TCCAGTAGTA GCATGCAAGT ACCTGTAATT 
GAATCATATG AGAAGCCTAT ATCACAGAAA AAAATTAAAA TAGAACCTGG GATCGAACCA 
CAGAGGACAG ATTATTATCC TGAAGAAATG TCACCCCCCT TAATGAACTC AGTGTCCCCC 
CCGCAAGCAT TGTTGCAAGA GAATCACCCT TCGGTCATCG TGCAGCCTGG GAAGAGACCT 
TTACCTGTGG AATCCCCGGA TACTCAAAGG AAGCGGAGGA TACACAGATG TGATTATGAT 
GGATGCAACA AAGTGTACAC TAAAAGCTCC CACTTGAAAG CACACAGAAG AACACACACA 
GGAGAAAAAC CCTACAAATG TACATGGGAA GGGTGCACAT GGAAGTTTGC TCGGTCTGAT 
GAACTAACAA GACATTTCCG AAAACATACT GGAATCAAAC CTTTCCAGTG CCCGGACTGT 
GACCGCAGCT TCTCCCGTTC TGACCATCTT GCCCTCCATA GGAAACGCCA CATGCTAGTC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016863768.1
CDS	602..1564
Translation	MESMKPNKYGVIYSTPLPEKFFQTPEGLSHGIQMEPVDLTVNKRSSPPSAGNSPSSLKFPSSHRRASPGLSMPSSSPPIKKYSPPSPGVQPFGVPLSMPPVMAAALSRHGIRSPGILPVIQPVVVQPVPFMYTSHLQQPLMVSLSEEMENSSSSMQVPVIESYEKPISQKKIKIEPGIEPQRTDYYPEEMSPPLMNSVSPPQALLQENHPSVIVQPGKRPLPVESPDTQRKRRIHRCDYDGCNKVYTKSSHLKAHRRTHTGEKPYKCTWEGCTWKFARSDELTRHFRKHTGIKPFQCPDCDRSFSRSDHLALHRKRHMLV

Target ORF information:

RefSeq Version	XM_017008279.1
Organism	Homo sapiens(human)
Definition	Homo sapiens Kruppel-like factor 3 (basic) (KLF3), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017008279.1

ORF Insert Sequence:

ATGGAATCCA TGAAGCCTAA CAAGTATGGG GTCATCTACT CCACACCATT GCCTGAGAAG 
TTCTTTCAGA CCCCAGAAGG TCTGTCGCAC GGAATACAGA TGGAGCCAGT GGACCTCACG 
GTGAACAAGC GGAGTTCACC CCCTTCGGCT GGGAATTCGC CCTCCTCTCT GAAGTTCCCG 
TCCTCACACC GGAGAGCCTC GCCTGGGTTG AGCATGCCTT CTTCCAGCCC ACCGATAAAA 
AAATACTCAC CCCCTTCTCC AGGCGTGCAG CCCTTCGGCG TGCCGCTGTC CATGCCACCA 
GTGATGGCAG CTGCCCTCTC GCGGCATGGA ATACGGAGCC CGGGGATCCT GCCCGTCATC 
CAGCCGGTGG TGGTGCAGCC CGTCCCCTTT ATGTACACAA GTCACCTCCA GCAGCCTCTC 
ATGGTCTCCT TATCGGAGGA GATGGAAAAT TCCAGTAGTA GCATGCAAGT ACCTGTAATT 
GAATCATATG AGAAGCCTAT ATCACAGAAA AAAATTAAAA TAGAACCTGG GATCGAACCA 
CAGAGGACAG ATTATTATCC TGAAGAAATG TCACCCCCCT TAATGAACTC AGTGTCCCCC 
CCGCAAGCAT TGTTGCAAGA GAATCACCCT TCGGTCATCG TGCAGCCTGG GAAGAGACCT 
TTACCTGTGG AATCCCCGGA TACTCAAAGG AAGCGGAGGA TACACAGATG TGATTATGAT 
GGATGCAACA AAGTGTACAC TAAAAGCTCC CACTTGAAAG CACACAGAAG AACACACACA 
GGAGAAAAAC CCTACAAATG TACATGGGAA GGGTGCACAT GGAAGTTTGC TCGGTCTGAT 
GAACTAACAA GACATTTCCG AAAACATACT GGAATCAAAC CTTTCCAGTG CCCGGACTGT 
GACCGCAGCT TCTCCCGTTC TGACCATCTT GCCCTCCATA GGAAACGCCA CATGCTAGTC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

KLF3 ( XM_017008279.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_016863768.1 Homo sapiens Kruppel like factor 3 (KLF3), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu38569
Clone ID Related Accession (Same CDS sequence)	XM_017008279.1 , XM_017008279.2
Accession Version	XM_017008279.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 963bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	Krueppel-like factor 3 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000004.12) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_017008279.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGAATCCA TGAAGCCTAA CAAGTATGGG GTCATCTACT CCACACCATT GCCTGAGAAG 
TTCTTTCAGA CCCCAGAAGG TCTGTCGCAC GGAATACAGA TGGAGCCAGT GGACCTCACG 
GTGAACAAGC GGAGTTCACC CCCTTCGGCT GGGAATTCGC CCTCCTCTCT GAAGTTCCCG 
TCCTCACACC GGAGAGCCTC GCCTGGGTTG AGCATGCCTT CTTCCAGCCC ACCGATAAAA 
AAATACTCAC CCCCTTCTCC AGGCGTGCAG CCCTTCGGCG TGCCGCTGTC CATGCCACCA 
GTGATGGCAG CTGCCCTCTC GCGGCATGGA ATACGGAGCC CGGGGATCCT GCCCGTCATC 
CAGCCGGTGG TGGTGCAGCC CGTCCCCTTT ATGTACACAA GTCACCTCCA GCAGCCTCTC 
ATGGTCTCCT TATCGGAGGA GATGGAAAAT TCCAGTAGTA GCATGCAAGT ACCTGTAATT 
GAATCATATG AGAAGCCTAT ATCACAGAAA AAAATTAAAA TAGAACCTGG GATCGAACCA 
CAGAGGACAG ATTATTATCC TGAAGAAATG TCACCCCCCT TAATGAACTC AGTGTCCCCC 
CCGCAAGCAT TGTTGCAAGA GAATCACCCT TCGGTCATCG TGCAGCCTGG GAAGAGACCT 
TTACCTGTGG AATCCCCGGA TACTCAAAGG AAGCGGAGGA TACACAGATG TGATTATGAT 
GGATGCAACA AAGTGTACAC TAAAAGCTCC CACTTGAAAG CACACAGAAG AACACACACA 
GGAGAAAAAC CCTACAAATG TACATGGGAA GGGTGCACAT GGAAGTTTGC TCGGTCTGAT 
GAACTAACAA GACATTTCCG AAAACATACT GGAATCAAAC CTTTCCAGTG CCCGGACTGT 
GACCGCAGCT TCTCCCGTTC TGACCATCTT GCCCTCCATA GGAAACGCCA CATGCTAGTC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016863768.1
CDS	722..1684
Translation	MESMKPNKYGVIYSTPLPEKFFQTPEGLSHGIQMEPVDLTVNKRSSPPSAGNSPSSLKFPSSHRRASPGLSMPSSSPPIKKYSPPSPGVQPFGVPLSMPPVMAAALSRHGIRSPGILPVIQPVVVQPVPFMYTSHLQQPLMVSLSEEMENSSSSMQVPVIESYEKPISQKKIKIEPGIEPQRTDYYPEEMSPPLMNSVSPPQALLQENHPSVIVQPGKRPLPVESPDTQRKRRIHRCDYDGCNKVYTKSSHLKAHRRTHTGEKPYKCTWEGCTWKFARSDELTRHFRKHTGIKPFQCPDCDRSFSRSDHLALHRKRHMLV

Target ORF information:

RefSeq Version	XM_017008279.2
Organism	Homo sapiens(human)
Definition	Homo sapiens Kruppel like factor 3 (KLF3), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017008279.2

ORF Insert Sequence:

ATGGAATCCA TGAAGCCTAA CAAGTATGGG GTCATCTACT CCACACCATT GCCTGAGAAG 
TTCTTTCAGA CCCCAGAAGG TCTGTCGCAC GGAATACAGA TGGAGCCAGT GGACCTCACG 
GTGAACAAGC GGAGTTCACC CCCTTCGGCT GGGAATTCGC CCTCCTCTCT GAAGTTCCCG 
TCCTCACACC GGAGAGCCTC GCCTGGGTTG AGCATGCCTT CTTCCAGCCC ACCGATAAAA 
AAATACTCAC CCCCTTCTCC AGGCGTGCAG CCCTTCGGCG TGCCGCTGTC CATGCCACCA 
GTGATGGCAG CTGCCCTCTC GCGGCATGGA ATACGGAGCC CGGGGATCCT GCCCGTCATC 
CAGCCGGTGG TGGTGCAGCC CGTCCCCTTT ATGTACACAA GTCACCTCCA GCAGCCTCTC 
ATGGTCTCCT TATCGGAGGA GATGGAAAAT TCCAGTAGTA GCATGCAAGT ACCTGTAATT 
GAATCATATG AGAAGCCTAT ATCACAGAAA AAAATTAAAA TAGAACCTGG GATCGAACCA 
CAGAGGACAG ATTATTATCC TGAAGAAATG TCACCCCCCT TAATGAACTC AGTGTCCCCC 
CCGCAAGCAT TGTTGCAAGA GAATCACCCT TCGGTCATCG TGCAGCCTGG GAAGAGACCT 
TTACCTGTGG AATCCCCGGA TACTCAAAGG AAGCGGAGGA TACACAGATG TGATTATGAT 
GGATGCAACA AAGTGTACAC TAAAAGCTCC CACTTGAAAG CACACAGAAG AACACACACA 
GGAGAAAAAC CCTACAAATG TACATGGGAA GGGTGCACAT GGAAGTTTGC TCGGTCTGAT 
GAACTAACAA GACATTTCCG AAAACATACT GGAATCAAAC CTTTCCAGTG CCCGGACTGT 
GACCGCAGCT TCTCCCGTTC TGACCATCTT GCCCTCCATA GGAAACGCCA CATGCTAGTC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

RNA sequencing analysis reveals protective role of kruppel-like factor 3 in colorectal cancer.
Oncotarget8(13)21984-21993(2017 Mar)
Wang X,Jiang Z,Zhang Y,Wang X,Liu L,Fan Z

Pooled-matrix protein interaction screens using Barcode Fusion Genetics.
Molecular systems biology12(4)863(2016 Apr)
Yachie N,Petsalaki E,Mellor JC,Weile J,Jacob Y,Verby M,Ozturk SB,Li S,Cote AG,Mosca R,Knapp JJ,Ko M,Yu A,Gebbia M,Sahni N,Yi S,Tyagi T,Sheykhkarimli D,Roth JF,Wong C,Musa L,Snider J,Liu YC,Yu H,Braun P,Stagljar I,Hao T,Calderwood MA,Pelletier L,Aloy P,Hill DE,Vidal M,Roth FP

Epigenetic silencing of Kruppel like factor-3 increases expression of pro-metastatic miR-182.
Cancer letters369(1)202-11(2015 Dec)
Sachdeva M,Dodd RD,Huang Z,Grenier C,Ma Y,Lev DC,Cardona DM,Murphy SK,Kirsch DG

The role of epigenetics in the endothelial cell shear stress response and atherosclerosis.
The international journal of biochemistry & cell biology67167-76(2015 Oct)
Dunn J,Simmons R,Thabet S,Jo H

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KLF3 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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