MRPL51 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	MRPL51
Entrez Gene ID	51258
Full Name	mitochondrial ribosomal protein L51
Synonyms	CDA09,HSPC241,MRP64,bMRP64
General protein information	Preferred Names mitochondrial ribosomal protein L51 Names 39S ribosomal protein L51, mitochondrial L51mt MRP-L51 bMRP-64 mitochondrial large ribosomal subunit protein mL51 mitochondrial ribosomal protein 64 mitochondrial ribosomal protein bMRP64
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 12 Map Location: 12p13.31
Summary	Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Pseudogenes corresponding to this gene are found on chromosomes 4p and 21q. [provided by RefSeq, Jul 2008].
Disorder MIM:	611855

mRNA and Protein(s)

mRNA	Protein	Name
NM_016497.3	NP_057581.2	39S ribosomal protein L51, mitochondrial
NM_016497.4	NP_057581.2	39S ribosomal protein L51, mitochondrial

Pathways from BioSystems

Homologies

Bos taurus (cattle)	MRPL51	NP_001094558.1
Rattus norvegicus (Norway rat)	Mrpl51	NP_001100091.1
Homo sapiens (human)	MRPL51	NP_057581.2
Pan troglodytes (chimpanzee)	MRPL51	XP_508954.2
	MRPL51	XP_001105685.1
Canis lupus familiaris (dog)	MRPL51	XP_003433522.1
Mus musculus (house mouse)	Mrpl51	NP_079871.1
Gallus gallus (chicken)	MRPL51	NP_001008675.1
Danio rerio (zebrafish)	zgc:110255	NP_001013494.1
Xenopus tropicalis (tropical clawed frog)	mrpl51	NP_001017085.1

Gene Ontology
Bibliography

Related articles in PubMed

Structures of the human mitochondrial ribosome in native states of assembly.
Brown A, Rathore S, Kimanius D, Aibara S, Bai XC, Rorbach J, Amunts A, Ramakrishnan V
Nature structural & molecular biology24(10)866-869(2017 Oct)

Structure of the large ribosomal subunit from human mitochondria.
Brown A, Amunts A, Bai XC, Sugimoto Y, Edwards PC, Murshudov G, Scheres SHW, Ramakrishnan V
Science (New York, N.Y.)346(6210)718-722(2014 Nov)

Properties of the C-terminal tail of human mitochondrial inner membrane protein Oxa1L and its interactions with mammalian mitochondrial ribosomes.
Haque ME, Elmore KB, Tripathy A, Koc H, Koc EC, Spremulli LL
The Journal of biological chemistry285(36)28353-62(2010 Sep)

Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
Hendrickson SL, Lautenberger JA, Chinn LW, Malasky M, Sezgin E, Kingsley LA, Goedert JJ, Kirk GD, Gomperts ED, Buchbinder SP, Troyer JL, O'Brien SJ
PloS one5(9)e12862(2010 Sep)

Identification and characterization of over 100 mitochondrial ribosomal protein pseudogenes in the human genome.
Zhang Z, Gerstein M
Genomics81(5)468-80(2003 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Observational study of gene-disease association. (HuGE Navigator)
Title: Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.

The following MRPL51 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MRPL51 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu30657	NM_016497.4 Latest version!	Homo sapiens mitochondrial ribosomal protein L51 (MRPL51), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu30657	NM_016497.3	Homo sapiens mitochondrial ribosomal protein L51 (MRPL51), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

MRPL51 ( NM_016497.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_057581.2 Homo sapiens mitochondrial ribosomal protein L51 (MRPL51), mRNA.

Price & Availability↑

CloneID	OHu30657
Clone ID Related Accession (Same CDS sequence)	NM_016497.3 , NM_016497.4
Accession Version	NM_016497.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 387bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	39S ribosomal protein L51, mitochondrial
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BI856229.1, AF212248.1 and BC014329.1. On Mar 7, 2008 this sequence version replaced NM_016497.2. ##Evidence-Data-START## Transcript exon combination :: BI601503.1, SRR1163658.56398.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCAGGGA ACCTCTTATC CGGGGCAGGT AGGCGCCTGT GGGACTGGGT GCCTCTGGCG 
TGCAGAAGCT TCTCTCTTGG TGTGCCTAGA TTGATCGGTA TAAGGCTCAC TCTCCCGCCC 
CCCAAAGTGG TTGATCGTTG GAACGAGAAA AGGGCCATGT TCGGAGTGTA TGACAACATC 
GGGATCCTGG GAAACTTTGA AAAGCACCCC AAAGAACTGA TCAGGGGGCC CATATGGCTT 
CGAGGTTGGA AAGGGAATGA ATTGCAACGT TGTATCCGAA AGAGGAAAAT GGTTGGAAGT 
AGAATGTTCG CTGATGACCT GCACAACCTT AATAAACGCA TCCGCTATCT CTACAAACAC 
TTTAACCGAC ATGGGAAGTT TCGATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_057581.2
CDS	170..556
Translation	MAGNLLSGAGRRLWDWVPLACRSFSLGVPRLIGIRLTLPPPKVVDRWNEKRAMFGVYDNIGILGNFEKHPKELIRGPIWLRGWKGNELQRCIRKRKMVGSRMFADDLHNLNKRIRYLYKHFNRHGKFR

Target ORF information:

RefSeq Version	NM_016497.3
Organism	Homo sapiens(human)
Definition	Homo sapiens mitochondrial ribosomal protein L51 (MRPL51), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_016497.3

ORF Insert Sequence:

ATGGCAGGGA ACCTCTTATC CGGGGCAGGT AGGCGCCTGT GGGACTGGGT GCCTCTGGCG 
TGCAGAAGCT TCTCTCTTGG TGTGCCTAGA TTGATCGGTA TAAGGCTCAC TCTCCCGCCC 
CCCAAAGTGG TTGATCGTTG GAACGAGAAA AGGGCCATGT TCGGAGTGTA TGACAACATC 
GGGATCCTGG GAAACTTTGA AAAGCACCCC AAAGAACTGA TCAGGGGGCC CATATGGCTT 
CGAGGTTGGA AAGGGAATGA ATTGCAACGT TGTATCCGAA AGAGGAAAAT GGTTGGAAGT 
AGAATGTTCG CTGATGACCT GCACAACCTT AATAAACGCA TCCGCTATCT CTACAAACAC 
TTTAACCGAC ATGGGAAGTT TCGATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MRPL51 ( NM_016497.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_057581.2 Homo sapiens mitochondrial ribosomal protein L51 (MRPL51), mRNA.

Price & Availability↑

CloneID	OHu30657
Clone ID Related Accession (Same CDS sequence)	NM_016497.3 , NM_016497.4
Accession Version	NM_016497.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 387bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-26
Organism	Homo sapiens(human)
Product	39S ribosomal protein L51, mitochondrial
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF212248.1, BC014329.1 and AC006064.10. On Nov 23, 2018 this sequence version replaced NM_016497.3. ##Evidence-Data-START## Transcript exon combination :: SRR1163657.458397.1, SRR1660805.184931.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta MANE Ensembl match :: ENST00000229238.5/ ENSP00000229238.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCAGGGA ACCTCTTATC CGGGGCAGGT AGGCGCCTGT GGGACTGGGT GCCTCTGGCG 
TGCAGAAGCT TCTCTCTTGG TGTGCCTAGA TTGATCGGTA TAAGGCTCAC TCTCCCGCCC 
CCCAAAGTGG TTGATCGTTG GAACGAGAAA AGGGCCATGT TCGGAGTGTA TGACAACATC 
GGGATCCTGG GAAACTTTGA AAAGCACCCC AAAGAACTGA TCAGGGGGCC CATATGGCTT 
CGAGGTTGGA AAGGGAATGA ATTGCAACGT TGTATCCGAA AGAGGAAAAT GGTTGGAAGT 
AGAATGTTCG CTGATGACCT GCACAACCTT AATAAACGCA TCCGCTATCT CTACAAACAC 
TTTAACCGAC ATGGGAAGTT TCGATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_057581.2
CDS	127..513
Translation	MAGNLLSGAGRRLWDWVPLACRSFSLGVPRLIGIRLTLPPPKVVDRWNEKRAMFGVYDNIGILGNFEKHPKELIRGPIWLRGWKGNELQRCIRKRKMVGSRMFADDLHNLNKRIRYLYKHFNRHGKFR

Target ORF information:

RefSeq Version	NM_016497.4
Organism	Homo sapiens(human)
Definition	Homo sapiens mitochondrial ribosomal protein L51 (MRPL51), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_016497.4

ORF Insert Sequence:

ATGGCAGGGA ACCTCTTATC CGGGGCAGGT AGGCGCCTGT GGGACTGGGT GCCTCTGGCG 
TGCAGAAGCT TCTCTCTTGG TGTGCCTAGA TTGATCGGTA TAAGGCTCAC TCTCCCGCCC 
CCCAAAGTGG TTGATCGTTG GAACGAGAAA AGGGCCATGT TCGGAGTGTA TGACAACATC 
GGGATCCTGG GAAACTTTGA AAAGCACCCC AAAGAACTGA TCAGGGGGCC CATATGGCTT 
CGAGGTTGGA AAGGGAATGA ATTGCAACGT TGTATCCGAA AGAGGAAAAT GGTTGGAAGT 
AGAATGTTCG CTGATGACCT GCACAACCTT AATAAACGCA TCCGCTATCT CTACAAACAC 
TTTAACCGAC ATGGGAAGTT TCGATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Structures of the human mitochondrial ribosome in native states of assembly.
Nature structural & molecular biology24(10)866-869(2017 Oct)
Brown A,Rathore S,Kimanius D,Aibara S,Bai XC,Rorbach J,Amunts A,Ramakrishnan V

Structure of the large ribosomal subunit from human mitochondria.
Science (New York, N.Y.)346(6210)718-722(2014 Nov)
Brown A,Amunts A,Bai XC,Sugimoto Y,Edwards PC,Murshudov G,Scheres SHW,Ramakrishnan V

Properties of the C-terminal tail of human mitochondrial inner membrane protein Oxa1L and its interactions with mammalian mitochondrial ribosomes.
The Journal of biological chemistry285(36)28353-62(2010 Sep)
Haque ME,Elmore KB,Tripathy A,Koc H,Koc EC,Spremulli LL

Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
PloS one5(9)e12862(2010 Sep)
Hendrickson SL,Lautenberger JA,Chinn LW,Malasky M,Sezgin E,Kingsley LA,Goedert JJ,Kirk GD,Gomperts ED,Buchbinder SP,Troyer JL,O'Brien SJ

Identification and characterization of over 100 mitochondrial ribosomal protein pseudogenes in the human genome.
Genomics81(5)468-80(2003 May)
Zhang Z,Gerstein M

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MRPL51 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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