RNF181 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	RNF181
Entrez Gene ID	51255
Full Name	ring finger protein 181
Synonyms	HSPC238
General protein information	Preferred Names ring finger protein 181 Names E3 ubiquitin-protein ligase RNF181 RING-type E3 ubiquitin transferase RNF181
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 2 Map Location: 2p11.2
Summary	RNF181 binds the integrin alpha-IIb (ITGA2B; MIM 607759)/beta-3 (ITGB3; MIM 173470) complex and has E3 ubiquitin ligase activity (Brophy et al., 2008 [PubMed 18331836]).[supplied by OMIM, Dec 2008].
Disorder MIM:	612490

mRNA and Protein(s)

mRNA	Protein	Name
XM_005264359.3	XP_005264416.1	E3 ubiquitin-protein ligase RNF181 isoform X1
NM_016494.3	NP_057578.1	E3 ubiquitin-protein ligase RNF181
NM_016494.4	NP_057578.1	E3 ubiquitin-protein ligase RNF181
XM_005264359.4	XP_005264416.1	E3 ubiquitin-protein ligase RNF181 isoform X1

Pathways from BioSystems

Homologies

Danio rerio (zebrafish)	rnf181	NP_956600.1
Xenopus tropicalis (tropical clawed frog)	rnf181	NP_001011200.1
Pan troglodytes (chimpanzee)	RNF181	XP_515588.1
Canis lupus familiaris (dog)	RNF181	XP_532978.2
Bos taurus (cattle)	RNF181	NP_001029682.1
Mus musculus (house mouse)	Rnf181	NP_079883.3
Rattus norvegicus (Norway rat)	Rnf181	NP_001007648.1
Homo sapiens (human)	RNF181	NP_057578.1
	RNF181	XP_001087546.1

Gene Ontology
Bibliography

Related articles in PubMed

Screening and verification of proteins that interact with HSPC238.
Tan JY, Chen JL, Huang X, Yuan CL
Oncology reports34(6)3097-103(2015 Dec)

Negative Regulation of CARD11 Signaling and Lymphoma Cell Survival by the E3 Ubiquitin Ligase RNF181.
Pedersen SM, Chan W, Jattani RP, Mackie dS, Pomerantz JL
Molecular and cellular biology36(5)794-808(2015 Dec)

Protein microarray characterization of the S-nitrosoproteome.
Lee YI, Giovinazzo D, Kang HC, Lee Y, Jeong JS, Doulias PT, Xie Z, Hu J, Ghasemi M, Ischiropoulos H, Qian J, Zhu H, Blackshaw S, Dawson VL, Dawson TM
Molecular & cellular proteomics : MCP13(1)63-72(2014 Jan)

Seven prostate cancer susceptibility loci identified by a multi-stage genome-wide association study.
Kote-Jarai Z, Olama AA, Giles GG, Severi G, Schleutker J, Weischer M, Campa D, Riboli E, Key T, Gronberg H, Hunter DJ, Kraft P, Thun MJ, Ingles S, Chanock S, Albanes D, Hayes RB, Neal DE, Hamdy FC, Donovan JL, Pharoah P, Schumacher F, Henderson BE, Stanford JL, Ostrander EA, Sorensen KD, D?rk T, Andriole G, Dickinson JL, Cybulski C, Lubinski J, Spurdle A, Clements JA, Chambers S, Aitken J, Gardiner RA, Thibodeau SN, Schaid D, John EM, Maier C, Vogel W, Cooney KA, Park JY, Cannon-Albright L, Brenner H, Habuchi T, Zhang HW, Lu YJ, Kaneva R, Muir K, Benlloch S, Leongamornlert DA, Saunders EJ, Tymrakiewicz M, Mahmud N, Guy M, O'Brien LT, Wilkinson RA, Hall AL, Sawyer EJ, Dadaev T, Morrison J, Dearnaley DP, Horwich A, Huddart RA, Khoo VS, Parker CC, Van As N, Woodhouse CJ, Thompson A, Christmas T, Ogden C, Cooper CS, Lophatonanon A, Southey MC, Hopper JL, English DR, Wahlfors T, Tammela TL, Klarskov P, Nordestgaard BG, R?der MA, Tybj?rg-Hansen A, Bojesen SE, Travis R, Canzian F, Kaaks R, Wiklund F, Aly M, Lindstrom S, Diver WR, Gapstur S, Stern MC, Corral R, Virtamo J, Cox A, Haiman CA, Le Marchand L, Fitzgerald L, Kolb S, Kwon EM, Karyadi DM, Orntoft TF, Borre M, Meyer A, Serth J, Yeager M, Berndt SI, Marthick JR, Patterson B, Wokolorczyk D, Batra J, Lose F, McDonnell SK, Joshi AD, Shahabi A, Rinckleb AE, Ray A, Sellers TA, Lin HY, Stephenson RA, Farnham J, Muller H, Rothenbacher D, Tsuchiya N, Narita S, Cao GW, Slavov C, Mitev V, Easton DF, Eeles RA, , ,
Nature genetics43(8)785-91(2011 Jul)

RN181 suppresses hepatocellular carcinoma growth by inhibition of the ERK/MAPK pathway.
Wang S, Huang X, Li Y, Lao H, Zhang Y, Dong H, Xu W, Li JL, Li M
Hepatology (Baltimore, Md.)53(6)1932-42(2011 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The identification and validation of proteins interacting with HSP238 may lead to the discovery of novel mechanisms through which HSPC238 suppresses tumorigenesis in human hepatocellular carcinoma
Title: Screening and verification of proteins that interact with HSPC238.

RNF181 limits the proliferation of human diffuse large B cell lymphoma cells that depend upon aberrant CARD11 signaling to NF-kappaB for growth and survival in culture.
Title: Negative Regulation of CARD11 Signaling and Lymphoma Cell Survival by the E3 Ubiquitin Ligase RNF181.

RN181 suppresses the tumorigenesis of hepatocellular carcinoma through the inhibition of ERK/MAPK signaling in the liver.
Title: RN181 suppresses hepatocellular carcinoma growth by inhibition of the ERK/MAPK pathway.

Data show LOC51255 (RNF181) protein located in the cytoplasm of HePG2 cell line.
Title: [Construction of recombinant eukaryotic expression vector pDsRed1-C3/LOC51255 and subcellular localization of LOC51255 protein in HePG2 cell line].

The presence of RN181 in human platelets was established; RN181 has ubiquitin E3 ligase activity.
Title: RN181, a novel ubiquitin E3 ligase that interacts with the KVGFFKR motif of platelet integrin alpha(IIb)beta3.

The following RNF181 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the RNF181 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu30049	NM_016494.4 Latest version!	Homo sapiens ring finger protein 181 (RNF181), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu35430	XM_005264359.4 Latest version!	Homo sapiens ring finger protein 181 (RNF181), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
View Old Accession Versions >>
OHu30049	NM_016494.3	Homo sapiens ring finger protein 181 (RNF181), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu35430	XM_005264359.3	Homo sapiens ring finger protein 181 (RNF181), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

RNF181 ( NM_016494.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_057578.1 Homo sapiens ring finger protein 181 (RNF181), mRNA.

Price & Availability↑

CloneID	OHu30049
Clone ID Related Accession (Same CDS sequence)	NM_016494.3 , NM_016494.4
Accession Version	NM_016494.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 462bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-15
Organism	Homo sapiens(human)
Product	E3 ubiquitin-protein ligase RNF181
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CB131242.1, BC002803.2 and AC016753.9. On Sep 15, 2005 this sequence version replaced NM_016494.2. ##Evidence-Data-START## Transcript exon combination :: BG431440.1, SRR1803613.133580.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCGTCCT ATTTCGATGA ACACGACTGC GAGCCGTCGG ACCCTGAGCA GGAGACGCGA 
ACCAACATGC TGCTGGAGCT CGCAAGGTCA CTTTTCAATA GGATGGACTT TGAAGACTTG 
GGGTTGGTAG TAGATTGGGA CCACCACCTG CCTCCACCAG CTGCCAAGAC TGTGGTTGAG 
AACCTCCCCA GGACAGTCAT CAGAGGCTCT CAGGCTGAGC TCAAGTGCCC CGTGTGTCTT 
TTGGAATTTG AGGAGGAGGA GACTGCCATT GAGATGCCTT GCCATCACCT TTTCCATTCC 
AGCTGCATTC TGCCCTGGCT AAGCAAGACA AATTCCTGTC CCTTGTGCCG CTATGAGCTG 
CCCACTGATG ACGACACTTA TGAGGAGCAC AGACGAGATA AGGCTCGAAA ACAGCAGCAG 
CAACACCGAC TGGAGAACCT CCATGGAGCC ATGTACACGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_057578.1
CDS	51..512
Translation	MASYFDEHDCEPSDPEQETRTNMLLELARSLFNRMDFEDLGLVVDWDHHLPPPAAKTVVENLPRTVIRGSQAELKCPVCLLEFEEEETAIEMPCHHLFHSSCILPWLSKTNSCPLCRYELPTDDDTYEEHRRDKARKQQQQHRLENLHGAMYT

Target ORF information:

RefSeq Version	NM_016494.3
Organism	Homo sapiens(human)
Definition	Homo sapiens ring finger protein 181 (RNF181), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_016494.3

ORF Insert Sequence:

ATGGCGTCCT ATTTCGATGA ACACGACTGC GAGCCGTCGG ACCCTGAGCA GGAGACGCGA 
ACCAACATGC TGCTGGAGCT CGCAAGGTCA CTTTTCAATA GGATGGACTT TGAAGACTTG 
GGGTTGGTAG TAGATTGGGA CCACCACCTG CCTCCACCAG CTGCCAAGAC TGTGGTTGAG 
AACCTCCCCA GGACAGTCAT CAGAGGCTCT CAGGCTGAGC TCAAGTGCCC CGTGTGTCTT 
TTGGAATTTG AGGAGGAGGA GACTGCCATT GAGATGCCTT GCCATCACCT TTTCCATTCC 
AGCTGCATTC TGCCCTGGCT AAGCAAGACA AATTCCTGTC CCTTGTGCCG CTATGAGCTG 
CCCACTGATG ACGACACTTA TGAGGAGCAC AGACGAGATA AGGCTCGAAA ACAGCAGCAG 
CAACACCGAC TGGAGAACCT CCATGGAGCC ATGTACACGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RNF181 ( NM_016494.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_057578.1 Homo sapiens ring finger protein 181 (RNF181), mRNA.

Price & Availability↑

CloneID	OHu30049
Clone ID Related Accession (Same CDS sequence)	NM_016494.3 , NM_016494.4
Accession Version	NM_016494.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 462bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-24
Organism	Homo sapiens(human)
Product	E3 ubiquitin-protein ligase RNF181
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC002803.2 and AC016753.9. On May 17, 2019 this sequence version replaced NM_016494.3. ##Evidence-Data-START## Transcript exon combination :: SRR1803616.284243.1, BG431440.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000306368.9/ ENSP00000306906.4 RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCGTCCT ATTTCGATGA ACACGACTGC GAGCCGTCGG ACCCTGAGCA GGAGACGCGA 
ACCAACATGC TGCTGGAGCT CGCAAGGTCA CTTTTCAATA GGATGGACTT TGAAGACTTG 
GGGTTGGTAG TAGATTGGGA CCACCACCTG CCTCCACCAG CTGCCAAGAC TGTGGTTGAG 
AACCTCCCCA GGACAGTCAT CAGAGGCTCT CAGGCTGAGC TCAAGTGCCC CGTGTGTCTT 
TTGGAATTTG AGGAGGAGGA GACTGCCATT GAGATGCCTT GCCATCACCT TTTCCATTCC 
AGCTGCATTC TGCCCTGGCT AAGCAAGACA AATTCCTGTC CCTTGTGCCG CTATGAGCTG 
CCCACTGATG ACGACACTTA TGAGGAGCAC AGACGAGATA AGGCTCGAAA ACAGCAGCAG 
CAACACCGAC TGGAGAACCT CCATGGAGCC ATGTACACGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_057578.1
CDS	20..481
Translation	MASYFDEHDCEPSDPEQETRTNMLLELARSLFNRMDFEDLGLVVDWDHHLPPPAAKTVVENLPRTVIRGSQAELKCPVCLLEFEEEETAIEMPCHHLFHSSCILPWLSKTNSCPLCRYELPTDDDTYEEHRRDKARKQQQQHRLENLHGAMYT

Target ORF information:

RefSeq Version	NM_016494.4
Organism	Homo sapiens(human)
Definition	Homo sapiens ring finger protein 181 (RNF181), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_016494.4

ORF Insert Sequence:

ATGGCGTCCT ATTTCGATGA ACACGACTGC GAGCCGTCGG ACCCTGAGCA GGAGACGCGA 
ACCAACATGC TGCTGGAGCT CGCAAGGTCA CTTTTCAATA GGATGGACTT TGAAGACTTG 
GGGTTGGTAG TAGATTGGGA CCACCACCTG CCTCCACCAG CTGCCAAGAC TGTGGTTGAG 
AACCTCCCCA GGACAGTCAT CAGAGGCTCT CAGGCTGAGC TCAAGTGCCC CGTGTGTCTT 
TTGGAATTTG AGGAGGAGGA GACTGCCATT GAGATGCCTT GCCATCACCT TTTCCATTCC 
AGCTGCATTC TGCCCTGGCT AAGCAAGACA AATTCCTGTC CCTTGTGCCG CTATGAGCTG 
CCCACTGATG ACGACACTTA TGAGGAGCAC AGACGAGATA AGGCTCGAAA ACAGCAGCAG 
CAACACCGAC TGGAGAACCT CCATGGAGCC ATGTACACGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RNF181 ( XM_005264359.3 ) cDNA ORF clone, Homo sapiens(human) -> XP_005264416.1 Homo sapiens ring finger protein 181 (RNF181), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu35430
Clone ID Related Accession (Same CDS sequence)	XM_005264359.3 , XM_005264359.4
Accession Version	XM_005264359.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 564bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	E3 ubiquitin-protein ligase RNF181 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000002.12) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 12, 2015 this sequence version replaced XM_005264359.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCGTCCT ATTTCGATGA ACACGACTGC GAGCCGTCGG ACCCTGAGCA GGAGACGCGA 
ACCAACATGC TGCTGGAGCT CGCAAGGTCA CTTTTCAATA GGATGGACTT TGAAGACTTG 
GGGTTGGTAG TAGATTGGGA CCACCACCTG CCTCCACCAG CTGCCAAGAC TGTGGTTGAG 
AACCTCCCCA GGACAGTCAT CAGAGGCTCT CAGGCTGCTC TCACCGTGCC CTGGGCCCAG 
TACTCAAGCT TCTTTCTGTT CATGGACTGC TGGGGGATGG AAGAAGAGTG GCAGTTGGGA 
GCAGGGGAGG GTGGTTATCA GCTTATGAAG ATCAGACCAA GGCTAGAACA CTACTCTACT 
TTTCTCAGAC AAATTCCTGT CCCTTGTGCC GCTATGAGCT GCCCACTGAT GACGACACTT 
ATGAGGAGCA CAGACGAGAT AAGGCTCGAA AACAGCAGCA GCAACACCGA CTGGAGAACC 
TCCATGGAGC CATGTACACG TGAGGAGGTT GGGGCTGAGT GCTGGCCCTC TGCGTCTTCC 
TTATTAACCT TGAATCCTCA TTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_005264416.1
CDS	497..1060
Translation	MASYFDEHDCEPSDPEQETRTNMLLELARSLFNRMDFEDLGLVVDWDHHLPPPAAKTVVENLPRTVIRGSQAALTVPWAQYSSFFLFMDCWGMEEEWQLGAGEGGYQLMKIRPRLEHYSTFLRQIPVPCAAMSCPLMTTLMRSTDEIRLENSSSNTDWRTSMEPCTREEVGAECWPSASSLLTLNPH

Target ORF information:

RefSeq Version	XM_005264359.3
Organism	Homo sapiens(human)
Definition	Homo sapiens ring finger protein 181 (RNF181), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005264359.3

ORF Insert Sequence:

ATGGCGTCCT ATTTCGATGA ACACGACTGC GAGCCGTCGG ACCCTGAGCA GGAGACGCGA 
ACCAACATGC TGCTGGAGCT CGCAAGGTCA CTTTTCAATA GGATGGACTT TGAAGACTTG 
GGGTTGGTAG TAGATTGGGA CCACCACCTG CCTCCACCAG CTGCCAAGAC TGTGGTTGAG 
AACCTCCCCA GGACAGTCAT CAGAGGCTCT CAGGCTGCTC TCACCGTGCC CTGGGCCCAG 
TACTCAAGCT TCTTTCTGTT CATGGACTGC TGGGGGATGG AAGAAGAGTG GCAGTTGGGA 
GCAGGGGAGG GTGGTTATCA GCTTATGAAG ATCAGACCAA GGCTAGAACA CTACTCTACT 
TTTCTCAGAC AAATTCCTGT CCCTTGTGCC GCTATGAGCT GCCCACTGAT GACGACACTT 
ATGAGGAGCA CAGACGAGAT AAGGCTCGAA AACAGCAGCA GCAACACCGA CTGGAGAACC 
TCCATGGAGC CATGTACACG TGAGGAGGTT GGGGCTGAGT GCTGGCCCTC TGCGTCTTCC 
TTATTAACCT TGAATCCTCA TTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RNF181 ( XM_005264359.4 ) cDNA ORF clone, Homo sapiens(human) -> XP_005264416.1 Homo sapiens ring finger protein 181 (RNF181), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu35430
Clone ID Related Accession (Same CDS sequence)	XM_005264359.3 , XM_005264359.4
Accession Version	XM_005264359.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 564bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	E3 ubiquitin-protein ligase RNF181 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000002.12) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_005264359.3. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCGTCCT ATTTCGATGA ACACGACTGC GAGCCGTCGG ACCCTGAGCA GGAGACGCGA 
ACCAACATGC TGCTGGAGCT CGCAAGGTCA CTTTTCAATA GGATGGACTT TGAAGACTTG 
GGGTTGGTAG TAGATTGGGA CCACCACCTG CCTCCACCAG CTGCCAAGAC TGTGGTTGAG 
AACCTCCCCA GGACAGTCAT CAGAGGCTCT CAGGCTGCTC TCACCGTGCC CTGGGCCCAG 
TACTCAAGCT TCTTTCTGTT CATGGACTGC TGGGGGATGG AAGAAGAGTG GCAGTTGGGA 
GCAGGGGAGG GTGGTTATCA GCTTATGAAG ATCAGACCAA GGCTAGAACA CTACTCTACT 
TTTCTCAGAC AAATTCCTGT CCCTTGTGCC GCTATGAGCT GCCCACTGAT GACGACACTT 
ATGAGGAGCA CAGACGAGAT AAGGCTCGAA AACAGCAGCA GCAACACCGA CTGGAGAACC 
TCCATGGAGC CATGTACACG TGAGGAGGTT GGGGCTGAGT GCTGGCCCTC TGCGTCTTCC 
TTATTAACCT TGAATCCTCA TTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_005264416.1
CDS	1942..2505
Translation	MASYFDEHDCEPSDPEQETRTNMLLELARSLFNRMDFEDLGLVVDWDHHLPPPAAKTVVENLPRTVIRGSQAALTVPWAQYSSFFLFMDCWGMEEEWQLGAGEGGYQLMKIRPRLEHYSTFLRQIPVPCAAMSCPLMTTLMRSTDEIRLENSSSNTDWRTSMEPCTREEVGAECWPSASSLLTLNPH

Target ORF information:

RefSeq Version	XM_005264359.4
Organism	Homo sapiens(human)
Definition	Homo sapiens ring finger protein 181 (RNF181), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005264359.4

ORF Insert Sequence:

ATGGCGTCCT ATTTCGATGA ACACGACTGC GAGCCGTCGG ACCCTGAGCA GGAGACGCGA 
ACCAACATGC TGCTGGAGCT CGCAAGGTCA CTTTTCAATA GGATGGACTT TGAAGACTTG 
GGGTTGGTAG TAGATTGGGA CCACCACCTG CCTCCACCAG CTGCCAAGAC TGTGGTTGAG 
AACCTCCCCA GGACAGTCAT CAGAGGCTCT CAGGCTGCTC TCACCGTGCC CTGGGCCCAG 
TACTCAAGCT TCTTTCTGTT CATGGACTGC TGGGGGATGG AAGAAGAGTG GCAGTTGGGA 
GCAGGGGAGG GTGGTTATCA GCTTATGAAG ATCAGACCAA GGCTAGAACA CTACTCTACT 
TTTCTCAGAC AAATTCCTGT CCCTTGTGCC GCTATGAGCT GCCCACTGAT GACGACACTT 
ATGAGGAGCA CAGACGAGAT AAGGCTCGAA AACAGCAGCA GCAACACCGA CTGGAGAACC 
TCCATGGAGC CATGTACACG TGAGGAGGTT GGGGCTGAGT GCTGGCCCTC TGCGTCTTCC 
TTATTAACCT TGAATCCTCA TTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Screening and verification of proteins that interact with HSPC238.
Oncology reports34(6)3097-103(2015 Dec)
Tan JY,Chen JL,Huang X,Yuan CL

Negative Regulation of CARD11 Signaling and Lymphoma Cell Survival by the E3 Ubiquitin Ligase RNF181.
Molecular and cellular biology36(5)794-808(2015 Dec)
Pedersen SM,Chan W,Jattani RP,Mackie dS,Pomerantz JL

Protein microarray characterization of the S-nitrosoproteome.
Molecular & cellular proteomics : MCP13(1)63-72(2014 Jan)
Lee YI,Giovinazzo D,Kang HC,Lee Y,Jeong JS,Doulias PT,Xie Z,Hu J,Ghasemi M,Ischiropoulos H,Qian J,Zhu H,Blackshaw S,Dawson VL,Dawson TM

Seven prostate cancer susceptibility loci identified by a multi-stage genome-wide association study.
Nature genetics43(8)785-91(2011 Jul)
Kote-Jarai Z,Olama AA,Giles GG,Severi G,Schleutker J,Weischer M,Campa D,Riboli E,Key T,Gronberg H,Hunter DJ,Kraft P,Thun MJ,Ingles S,Chanock S,Albanes D,Hayes RB,Neal DE,Hamdy FC,Donovan JL,Pharoah P,Schumacher F,Henderson BE,Stanford JL,Ostrander EA,Sorensen KD,D?rk T,Andriole G,Dickinson JL,Cybulski C,Lubinski J,Spurdle A,Clements JA,Chambers S,Aitken J,Gardiner RA,Thibodeau SN,Schaid D,John EM,Maier C,Vogel W,Cooney KA,Park JY,Cannon-Albright L,Brenner H,Habuchi T,Zhang HW,Lu YJ,Kaneva R,Muir K,Benlloch S,Leongamornlert DA,Saunders EJ,Tymrakiewicz M,Mahmud N,Guy M,O'Brien LT,Wilkinson RA,Hall AL,Sawyer EJ,Dadaev T,Morrison J,Dearnaley DP,Horwich A,Huddart RA,Khoo VS,Parker CC,Van As N,Woodhouse CJ,Thompson A,Christmas T,Ogden C,Cooper CS,Lophatonanon A,Southey MC,Hopper JL,English DR,Wahlfors T,Tammela TL,Klarskov P,Nordestgaard BG,R?der MA,Tybj?rg-Hansen A,Bojesen SE,Travis R,Canzian F,Kaaks R,Wiklund F,Aly M,Lindstrom S,Diver WR,Gapstur S,Stern MC,Corral R,Virtamo J,Cox A,Haiman CA,Le Marchand L,Fitzgerald L,Kolb S,Kwon EM,Karyadi DM,Orntoft TF,Borre M,Meyer A,Serth J,Yeager M,Berndt SI,Marthick JR,Patterson B,Wokolorczyk D,Batra J,Lose F,McDonnell SK,Joshi AD,Shahabi A,Rinckleb AE,Ray A,Sellers TA,Lin HY,Stephenson RA,Farnham J,Muller H,Rothenbacher D,Tsuchiya N,Narita S,Cao GW,Slavov C,Mitev V,Easton DF,Eeles RA,,,

RN181 suppresses hepatocellular carcinoma growth by inhibition of the ERK/MAPK pathway.
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Wang S,Huang X,Li Y,Lao H,Zhang Y,Dong H,Xu W,Li JL,Li M

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RNF181 cDNA ORF clone, Homo sapiens(human)

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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