ELOA2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	ELOA2
Entrez Gene ID	51224
Full Name	elongin A2
Synonyms	HsT832,TCEB3B,TCEB3L
General protein information	Preferred Names elongin A2 Names elongin-A2 RNA polymerase II transcription factor SIII subunit A2 transcription elongation factor (SIII) elongin A2 elongin A2 transcription elongation factor B polypeptide 3B transcription elongation factor B subunit 3B
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 18 Map Location: 18q21.1
Summary	This gene encodes the transcriptionally active subunit of the SIII (or elongin) transcription elongation factor complex, which also includes two regulatory subunits, elongins B and C. This complex acts to increase the rate of RNA chain elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites along the DNA template. Whereas a related protein with similar function, elongin A, is ubiquitously expressed, the encoded protein is specifically expressed in the testis, suggesting it may have a role in spermatogenesis. [provided by RefSeq, Jul 2008].
Disorder MIM:	609522

mRNA and Protein(s)

mRNA	Protein	Name
NM_016427.2	NP_057511.2	elongin-A2

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	TCEB3B	XP_523920.3
Homo sapiens (human)	TCEB3B	NP_057511.2
	TCEB3B	XP_001091087.1

Gene Ontology
Bibliography

Related articles in PubMed

A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.
Lim J, Hao T, Shaw C, Patel AJ, Szab? G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barab?si AL, Vidal M, Zoghbi HY
Cell125(4)801-14(2006 May)

Identification and characterization of Elongin A2, a new member of the Elongin family of transcription elongation factors, specifically expressed in the testis.
Aso T, Yamazaki K, Amimoto K, Kuroiwa A, Higashi H, Matsuda Y, Kitajima S, Hatakeyama M
The Journal of biological chemistry275(9)6546-52(2000 Mar)

Elongin (SIII): a multisubunit regulator of elongation by RNA polymerase II.
Aso T, Lane WS, Conaway JW, Conaway RC
Science (New York, N.Y.)269(5229)1439-43(1995 Sep)

RNA polymerase II transcription factor SIII. I. Identification, purification, and properties.
Bradsher JN, Jackson KW, Conaway RC, Conaway JW
The Journal of biological chemistry268(34)25587-93(1993 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following ELOA2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ELOA2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu30207	NM_016427.2 Latest version!	Homo sapiens elongin A2 (ELOA2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$279.50-$391.30 $559.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

ELOA2 ( NM_016427.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_057511.2 Homo sapiens elongin A2 (ELOA2), mRNA.

Price & Availability↑

CloneID	OHu30207
Clone ID Related Accession (Same CDS sequence)	NM_016427.2
Accession Version	NM_016427.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2262bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-02
Organism	Homo sapiens(human)
Product	elongin-A2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC036022.1 and AB030834.1. This sequence is a reference standard in the RefSeqGene project. On Mar 15, 2004 this sequence version replaced NM_016427.1. ##Evidence-Data-START## Transcript is intronless :: BC036022.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCGGCAG GGTCCACTAC GCTGCACGCA GTGGAGAAGC TGCAGGTGCG TCTGGCCACT 
AAGACGGAGC CGAAAAAGCT AGAGAAATAT TTGCAGAAAC TCTCCGCCTT GCCCATGACG 
GCAGACATCC TGGCGGAGAC TGGAATCAGA AAGACGGTGA AGCGCCTGCG GAAGCACCAG 
CACGTGGGCG ACTTTGCCAG AGACTTAGCG GCCCGGTGGA AGAAGCTGGT GCTCGTGGAC 
CGAAACACCC GGCCTGGCCC ACAGGACCCT GAGGAGAGCG CTTCCCGACA GCGCTTCGGG 
GAGGCTCTTC AGGACCAGGA AAAGGCCTGG GGCTTCCCAG AAAACGCGAC GGCCCCCAGG 
AGCCCATCTC ACAGCCCTGA GCACAGACGG ACAGCACGCA GAACACCTCC GGGGCAACAG 
AGACCTCACC CGAGGTCTCA CAGTCGCGAG CCCAGAGCTG AGAGAAAGTG CCCCAGAATA 
GCCCCAGCTG ATTCCGGCCG CTATCGGGCC TCTCCAACGC GCACAGCTCC CCTCCGGATG 
CCCGAGGGCC CTGAGCCCGC TGCGCCCGGG AAGCAACCCG GAAGAGGCCA CACTCACGCG 
GCTCAGGGCG GGCCTCTGCT GTGTCCAGGC TGCCAGGGCC AACCCCAGGG GAAAGCCGTT 
GTGAGCCACA GCAAGGGGCA CAAATCGTCT CGCCAGGAAA AACGCCCCTT GTGTGCCCAG 
GGAGATTGGC ACTCCCCTAC TTTGATCAGG GAGAAATCAT GCGGGGCCTG CTTAAGAGAG 
GAAACCCCAA GGATGCCCTC CTGGGCAAGT GCCAGGGACA GGCAGCCTTC GGACTTCAAG 
ACAGACAAGG AAGGGGGGCA AGCTGGCAGC GGCCAGCGTG TCCCTGCCTT GGAGGAGGCT 
CCAGACAGTC ACCAGAAGAG GCCTCAGCAC AGTCACTCGA ACAAGAAGAG GCCCAGTCTA 
GACGGCCGGG ACCCAGGAAA TGGGACACAC GGCCTGTCGC CCGAGGAGAA AGAGCAGCTT 
TCCAACGACC GAGAGACTCA AGAGGGGAAG CCACCGACTG CTCATTTGGA CAGAACGTCC 
GTGAGCTCCC TCTCTGAGGT GGAGGAGGTA GATATGGCTG AGGAATTCGA GCAGCCCACT 
CTGTCATGTG AAAAATACCT CACCTACGAT CAGTTGCGGA AGCAAAAGAA AAAGACTGGA 
AAATCTGCCA CCACTGCACT TGGAGATAAA CAAAGGAAAG CAAACGAATC CAAGGGCACT 
CGTGAGTCCT GGGATTCGGC TAAGAAATTG CCTCCTGTCC AGGAAAGCCA GTCAGAGAGG 
CTGCAGGCGG CCGGCGCTGA TTCCGCCGGG CCGAAAACGG TGCCCAGCCA TGTCTTCTCA 
GAGCTCTGGG ACCTCTCAGA GGCCTGGATG CAGGCCAACT ACGATCCGCT TTCGGATTCT 
GACTCCATGA CCTCCCAGGC AAAGCCAGAA GCACTCTCTT CACCAAAGTT CCGGGAGGAA 
GCTGCTTTCC CTGGACGCAG AGTGAATGCT AAGATGCCGG TGTACTCGGG CTCCAGGCCT 
GCCTGCCAGC TCCAGGTGCC GACGCTGCGC CAGCAGTGTG CCCAGGTGCT TAGAAACAAT 
CCGGACGCCC TCAGCGACGT GGGAGAGGTC CCCTACTGGG TTCTTGAACC TGTTCTGGAA 
GGGTGGAGGC CCGATCAGCT GTATCGCAGA AAGAAAGACA ATCACGCACT CGTTAGAGAG 
ACAGACGAAT TACGGAGGAA TCATTGTTTC CAGGACTTCA AGGAAGAAAA GCCACAGGAA 
AACAAAACTT GGAGGGAGCA GTACCTGCGG CTTCCGGACG CCCCAGAGCA GCGGCTGAGA 
GTAATGACAA CGAATATCCG ATCTGCACGT GGAAACAACC CCAACGGCAG AGAGGCAAAG 
ATGATCTGTT TCAAATCTGT GGCCAAGACG CCTTATGATA CTTCAAGGAG GCAAGAGAAG 
TCTGCAGGAG ACGCTGACCC CGAAAATGGG GAGATCAAGC CAGCCTCCAA GCCCGCGGGA 
AGCAGCCACA CTCCCTCCAG CCAGAGCAGC AGCGGCGGTG GCAGAGACAG CAGCAGCAGC 
ATCCTTCGCT GGCTCCCTGA GAAGCGGGCC AACCCCTGCC TGAGCAGCAG CAATGAGCAC 
GCGGCGCCCG CGGCCAAAAC CCGGAAACAG GCTGCCAAGA AAGTGGCCCC GCTGATGGCC 
AAGGCAATTC GAGACTACAA GAGAAGATTC TCCCGACGAT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_057511.2
CDS	354..2615
Translation	MAAGSTTLHAVEKLQVRLATKTEPKKLEKYLQKLSALPMTADILAETGIRKTVKRLRKHQHVGDFARDLAARWKKLVLVDRNTRPGPQDPEESASRQRFGEALQDQEKAWGFPENATAPRSPSHSPEHRRTARRTPPGQQRPHPRSHSREPRAERKCPRIAPADSGRYRASPTRTAPLRMPEGPEPAAPGKQPGRGHTHAAQGGPLLCPGCQGQPQGKAVVSHSKGHKSSRQEKRPLCAQGDWHSPTLIREKSCGACLREETPRMPSWASARDRQPSDFKTDKEGGQAGSGQRVPALEEAPDSHQKRPQHSHSNKKRPSLDGRDPGNGTHGLSPEEKEQLSNDRETQEGKPPTAHLDRTSVSSLSEVEEVDMAEEFEQPTLSCEKYLTYDQLRKQKKKTGKSATTALGDKQRKANESKGTRESWDSAKKLPPVQESQSERLQAAGADSAGPKTVPSHVFSELWDLSEAWMQANYDPLSDSDSMTSQAKPEALSSPKFREEAAFPGRRVNAKMPVYSGSRPACQLQVPTLRQQCAQVLRNNPDALSDVGEVPYWVLEPVLEGWRPDQLYRRKKDNHALVRETDELRRNHCFQDFKEEKPQENKTWREQYLRLPDAPEQRLRVMTTNIRSARGNNPNGREAKMICFKSVAKTPYDTSRRQEKSAGDADPENGEIKPASKPAGSSHTPSSQSSSGGGRDSSSSILRWLPEKRANPCLSSSNEHAAPAAKTRKQAAKKVAPLMAKAIRDYKRRFSRR

Target ORF information:

RefSeq Version	NM_016427.2
Organism	Homo sapiens(human)
Definition	Homo sapiens elongin A2 (ELOA2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_016427.2

ORF Insert Sequence:

ATGGCGGCAG GGTCCACTAC GCTGCACGCA GTGGAGAAGC TGCAGGTGCG TCTGGCCACT 
AAGACGGAGC CGAAAAAGCT AGAGAAATAT TTGCAGAAAC TCTCCGCCTT GCCCATGACG 
GCAGACATCC TGGCGGAGAC TGGAATCAGA AAGACGGTGA AGCGCCTGCG GAAGCACCAG 
CACGTGGGCG ACTTTGCCAG AGACTTAGCG GCCCGGTGGA AGAAGCTGGT GCTCGTGGAC 
CGAAACACCC GGCCTGGCCC ACAGGACCCT GAGGAGAGCG CTTCCCGACA GCGCTTCGGG 
GAGGCTCTTC AGGACCAGGA AAAGGCCTGG GGCTTCCCAG AAAACGCGAC GGCCCCCAGG 
AGCCCATCTC ACAGCCCTGA GCACAGACGG ACAGCACGCA GAACACCTCC GGGGCAACAG 
AGACCTCACC CGAGGTCTCA CAGTCGCGAG CCCAGAGCTG AGAGAAAGTG CCCCAGAATA 
GCCCCAGCTG ATTCCGGCCG CTATCGGGCC TCTCCAACGC GCACAGCTCC CCTCCGGATG 
CCCGAGGGCC CTGAGCCCGC TGCGCCCGGG AAGCAACCCG GAAGAGGCCA CACTCACGCG 
GCTCAGGGCG GGCCTCTGCT GTGTCCAGGC TGCCAGGGCC AACCCCAGGG GAAAGCCGTT 
GTGAGCCACA GCAAGGGGCA CAAATCGTCT CGCCAGGAAA AACGCCCCTT GTGTGCCCAG 
GGAGATTGGC ACTCCCCTAC TTTGATCAGG GAGAAATCAT GCGGGGCCTG CTTAAGAGAG 
GAAACCCCAA GGATGCCCTC CTGGGCAAGT GCCAGGGACA GGCAGCCTTC GGACTTCAAG 
ACAGACAAGG AAGGGGGGCA AGCTGGCAGC GGCCAGCGTG TCCCTGCCTT GGAGGAGGCT 
CCAGACAGTC ACCAGAAGAG GCCTCAGCAC AGTCACTCGA ACAAGAAGAG GCCCAGTCTA 
GACGGCCGGG ACCCAGGAAA TGGGACACAC GGCCTGTCGC CCGAGGAGAA AGAGCAGCTT 
TCCAACGACC GAGAGACTCA AGAGGGGAAG CCACCGACTG CTCATTTGGA CAGAACGTCC 
GTGAGCTCCC TCTCTGAGGT GGAGGAGGTA GATATGGCTG AGGAATTCGA GCAGCCCACT 
CTGTCATGTG AAAAATACCT CACCTACGAT CAGTTGCGGA AGCAAAAGAA AAAGACTGGA 
AAATCTGCCA CCACTGCACT TGGAGATAAA CAAAGGAAAG CAAACGAATC CAAGGGCACT 
CGTGAGTCCT GGGATTCGGC TAAGAAATTG CCTCCTGTCC AGGAAAGCCA GTCAGAGAGG 
CTGCAGGCGG CCGGCGCTGA TTCCGCCGGG CCGAAAACGG TGCCCAGCCA TGTCTTCTCA 
GAGCTCTGGG ACCTCTCAGA GGCCTGGATG CAGGCCAACT ACGATCCGCT TTCGGATTCT 
GACTCCATGA CCTCCCAGGC AAAGCCAGAA GCACTCTCTT CACCAAAGTT CCGGGAGGAA 
GCTGCTTTCC CTGGACGCAG AGTGAATGCT AAGATGCCGG TGTACTCGGG CTCCAGGCCT 
GCCTGCCAGC TCCAGGTGCC GACGCTGCGC CAGCAGTGTG CCCAGGTGCT TAGAAACAAT 
CCGGACGCCC TCAGCGACGT GGGAGAGGTC CCCTACTGGG TTCTTGAACC TGTTCTGGAA 
GGGTGGAGGC CCGATCAGCT GTATCGCAGA AAGAAAGACA ATCACGCACT CGTTAGAGAG 
ACAGACGAAT TACGGAGGAA TCATTGTTTC CAGGACTTCA AGGAAGAAAA GCCACAGGAA 
AACAAAACTT GGAGGGAGCA GTACCTGCGG CTTCCGGACG CCCCAGAGCA GCGGCTGAGA 
GTAATGACAA CGAATATCCG ATCTGCACGT GGAAACAACC CCAACGGCAG AGAGGCAAAG 
ATGATCTGTT TCAAATCTGT GGCCAAGACG CCTTATGATA CTTCAAGGAG GCAAGAGAAG 
TCTGCAGGAG ACGCTGACCC CGAAAATGGG GAGATCAAGC CAGCCTCCAA GCCCGCGGGA 
AGCAGCCACA CTCCCTCCAG CCAGAGCAGC AGCGGCGGTG GCAGAGACAG CAGCAGCAGC 
ATCCTTCGCT GGCTCCCTGA GAAGCGGGCC AACCCCTGCC TGAGCAGCAG CAATGAGCAC 
GCGGCGCCCG CGGCCAAAAC CCGGAAACAG GCTGCCAAGA AAGTGGCCCC GCTGATGGCC 
AAGGCAATTC GAGACTACAA GAGAAGATTC TCCCGACGAT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.
Cell125(4)801-14(2006 May)
Lim J,Hao T,Shaw C,Patel AJ,Szab? G,Rual JF,Fisk CJ,Li N,Smolyar A,Hill DE,Barab?si AL,Vidal M,Zoghbi HY

Identification and characterization of Elongin A2, a new member of the Elongin family of transcription elongation factors, specifically expressed in the testis.
The Journal of biological chemistry275(9)6546-52(2000 Mar)
Aso T,Yamazaki K,Amimoto K,Kuroiwa A,Higashi H,Matsuda Y,Kitajima S,Hatakeyama M

Elongin (SIII): a multisubunit regulator of elongation by RNA polymerase II.
Science (New York, N.Y.)269(5229)1439-43(1995 Sep)
Aso T,Lane WS,Conaway JW,Conaway RC

RNA polymerase II transcription factor SIII. I. Identification, purification, and properties.
The Journal of biological chemistry268(34)25587-93(1993 Dec)
Bradsher JN,Jackson KW,Conaway RC,Conaway JW

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ELOA2 cDNA ORF clone, Homo sapiens(human)

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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