PCP4 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	PCP4
Entrez Gene ID	5121
Full Name	Purkinje cell protein 4
Synonyms	PEP-19
General protein information	Preferred Names Purkinje cell protein 4 Names calmodulin regulator protein PCP4 brain specific polypeptide PEP19 brain-specific antigen PCP-4 brain-specific polypeptide PEP-19
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 21 Map Location: 21q22.2
Disorder MIM:	601629

mRNA and Protein(s)

mRNA	Protein	Name
NM_006198.2	NP_006189.2	calmodulin regulator protein PCP4
NM_006198.3	NP_006189.2	calmodulin regulator protein PCP4

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	PCP4	XP_853359.1
Bos taurus (cattle)	PCP4	NP_001071604.1
Mus musculus (house mouse)	Pcp4	NP_032817.1
Pan troglodytes (chimpanzee)	PCP4	XP_531603.2
Rattus norvegicus (Norway rat)	Pcp4	NP_037134.1
Gallus gallus (chicken)	PCP4	NP_001265077.1
Homo sapiens (human)	PCP4	NP_006189.2

Gene Ontology
Bibliography

Related articles in PubMed

Purkinje cell protein 4 expression is associated with DNA methylation status in aldosterone-producing adenoma.
Kobuke K, Oki K, Gomez-Sanchez CE, Ohno H, Itcho K, Yoshii Y, Yoneda M, Hattori N
The Journal of clinical endocrinology and metabolism(2017 Dec)

PCP4/PEP19 promotes migration, invasion and adhesion in human breast cancer MCF-7 and T47D cells.
Yoshimura T, Hamada T, Hijioka H, Souda M, Hatanaka K, Yoshioka T, Yamada S, Tsutsui M, Umekita Y, Nakamura N, Tanimoto A
Oncotarget7(31)49065-49074(2016 Aug)

Anti-apoptotic effects of PCP4/PEP19 in human breast cancer cell lines: a novel oncotarget.
Hamada T, Souda M, Yoshimura T, Sasaguri S, Hatanaka K, Tasaki T, Yoshioka T, Ohi Y, Yamada S, Tsutsui M, Umekita Y, Tanimoto A
Oncotarget5(15)6076-86(2014 Aug)

Distribution of PCP4 protein in the forebrain of adult mice.
Renelt M, von Bohlen und Halbach V, von Bohlen und Halbach O
Acta histochemica116(6)1056-61(2014 Jul)

PCP4: a regulator of aldosterone synthesis in human adrenocortical tissues.
Felizola SJ, Nakamura Y, Ono Y, Kitamura K, Kikuchi K, Onodera Y, Ise K, Takase K, Sugawara A, Hattangady N, Rainey WE, Satoh F, Sasano H
Journal of molecular endocrinology52(2)159-67(2014 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data indicated that PCP4/PEP19 regulates apoptosis but exact mechanism is still unknown.
Title: Anti-apoptotic effects of PCP4/PEP19 in human breast cancer cell lines: a novel oncotarget.

PCP4 protein is highly expressed in the olfactory bulb and caudate putamen and PCP4 expressing cells in the brain are of neuronal origin.
Title: Distribution of PCP4 protein in the forebrain of adult mice.

PCP4 is a regulator of aldosterone production in normal, hyperplastic, and neoplastic human adrenocortical cells.
Title: PCP4: a regulator of aldosterone synthesis in human adrenocortical tissues.

This study demonstrate that Pcp4 overexpression extended these effects later in development by modulating genes in line with the maturation of neurons in the cerebellum.
Title: Developmental molecular and functional cerebellar alterations induced by PCP4/PEP19 overexpression: implications for Down syndrome.

The calmodulin regulator protein, PEP-19, sensitizes ATP-induced Ca2+ release.
Title: The calmodulin regulator protein, PEP-19, sensitizes ATP-induced Ca2+ release.

The following PCP4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PCP4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu29593	NM_006198.3 Latest version!	Homo sapiens Purkinje cell protein 4 (PCP4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu29593	NM_006198.2	Homo sapiens Purkinje cell protein 4 (PCP4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

PCP4 ( NM_006198.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_006189.2 Homo sapiens Purkinje cell protein 4 (PCP4), mRNA.

Price & Availability↑

CloneID	OHu29593
Clone ID Related Accession (Same CDS sequence)	NM_006198.2 , NM_006198.3
Accession Version	NM_006198.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 189bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-30
Organism	Homo sapiens(human)
Product	calmodulin regulator protein PCP4
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from U52969.1 and BQ287895.1. On Jun 16, 2004 this sequence version replaced NM_006198.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BM681424.1, ERR279829.1212.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAGTGAGC GACAAGGTGC TGGGGCAACC AATGGAAAAG ACAAGACATC TGGTGAAAAT 
GATGGACAGA AGAAAGTTCA AGAAGAATTT GACATTGACA TGGATGCACC AGAGACAGAA 
CGTGCAGCGG TGGCCATTCA GTCTCAGTTC AGAAAATTCC AGAAGAAGAA GGCTGGGTCT 
CAGTCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006189.2
CDS	82..270
Translation	MSERQGAGATNGKDKTSGENDGQKKVQEEFDIDMDAPETERAAVAIQSQFRKFQKKKAGSQS

Target ORF information:

RefSeq Version	NM_006198.2
Organism	Homo sapiens(human)
Definition	Homo sapiens Purkinje cell protein 4 (PCP4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006198.2

ORF Insert Sequence:

ATGAGTGAGC GACAAGGTGC TGGGGCAACC AATGGAAAAG ACAAGACATC TGGTGAAAAT 
GATGGACAGA AGAAAGTTCA AGAAGAATTT GACATTGACA TGGATGCACC AGAGACAGAA 
CGTGCAGCGG TGGCCATTCA GTCTCAGTTC AGAAAATTCC AGAAGAAGAA GGCTGGGTCT 
CAGTCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PCP4 ( NM_006198.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_006189.2 Homo sapiens Purkinje cell protein 4 (PCP4), mRNA.

Price & Availability↑

CloneID	OHu29593
Clone ID Related Accession (Same CDS sequence)	NM_006198.2 , NM_006198.3
Accession Version	NM_006198.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 189bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Homo sapiens(human)
Product	calmodulin regulator protein PCP4
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from U52969.1 and BQ287895.1. On Nov 23, 2018 this sequence version replaced NM_006198.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK289964.1, U52969.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000328619.10/ ENSP00000329403.5 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGAGTGAGC GACAAGGTGC TGGGGCAACC AATGGAAAAG ACAAGACATC TGGTGAAAAT 
GATGGACAGA AGAAAGTTCA AGAAGAATTT GACATTGACA TGGATGCACC AGAGACAGAA 
CGTGCAGCGG TGGCCATTCA GTCTCAGTTC AGAAAATTCC AGAAGAAGAA GGCTGGGTCT 
CAGTCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006189.2
CDS	65..253
Translation	MSERQGAGATNGKDKTSGENDGQKKVQEEFDIDMDAPETERAAVAIQSQFRKFQKKKAGSQS

Target ORF information:

RefSeq Version	NM_006198.3
Organism	Homo sapiens(human)
Definition	Homo sapiens Purkinje cell protein 4 (PCP4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006198.3

ORF Insert Sequence:

ATGAGTGAGC GACAAGGTGC TGGGGCAACC AATGGAAAAG ACAAGACATC TGGTGAAAAT 
GATGGACAGA AGAAAGTTCA AGAAGAATTT GACATTGACA TGGATGCACC AGAGACAGAA 
CGTGCAGCGG TGGCCATTCA GTCTCAGTTC AGAAAATTCC AGAAGAAGAA GGCTGGGTCT 
CAGTCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Purkinje cell protein 4 expression is associated with DNA methylation status in aldosterone-producing adenoma.
The Journal of clinical endocrinology and metabolism(2017 Dec)
Kobuke K,Oki K,Gomez-Sanchez CE,Ohno H,Itcho K,Yoshii Y,Yoneda M,Hattori N

PCP4/PEP19 promotes migration, invasion and adhesion in human breast cancer MCF-7 and T47D cells.
Oncotarget7(31)49065-49074(2016 Aug)
Yoshimura T,Hamada T,Hijioka H,Souda M,Hatanaka K,Yoshioka T,Yamada S,Tsutsui M,Umekita Y,Nakamura N,Tanimoto A

Anti-apoptotic effects of PCP4/PEP19 in human breast cancer cell lines: a novel oncotarget.
Oncotarget5(15)6076-86(2014 Aug)
Hamada T,Souda M,Yoshimura T,Sasaguri S,Hatanaka K,Tasaki T,Yoshioka T,Ohi Y,Yamada S,Tsutsui M,Umekita Y,Tanimoto A

Distribution of PCP4 protein in the forebrain of adult mice.
Acta histochemica116(6)1056-61(2014 Jul)
Renelt M,von Bohlen und Halbach V,von Bohlen und Halbach O

PCP4: a regulator of aldosterone synthesis in human adrenocortical tissues.
Journal of molecular endocrinology52(2)159-67(2014 Apr)
Felizola SJ,Nakamura Y,Ono Y,Kitamura K,Kikuchi K,Onodera Y,Ise K,Takase K,Sugawara A,Hattangady N,Rainey WE,Satoh F,Sasano H

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PCP4 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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