IPO11 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	IPO11
Entrez Gene ID	51194
Full Name	importin 11
Synonyms	RanBP11
General protein information	Preferred Names importin 11 Names importin-11 Ran binding protein 11 imp11 ran-binding protein 11
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 5 Map Location: 5q12.1
Summary	Importins, including IPO11, are a members of the karyopherin/importin-beta family of transport receptors (see KPNB1; 602738) that mediate nucleocytoplasmic transport of protein and RNA cargoes (Plafker and Macara, 2000 [PubMed 11032817]).[supplied by OMIM, Sep 2008].
Disorder MIM:	610889

mRNA and Protein(s)

mRNA	Protein	Name
NM_001134779.1	NP_001128251.1	importin-11 isoform 1
NM_016338.4	NP_057422.3	importin-11 isoform 2

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	IPO11	XP_001136069.2
Rattus norvegicus (Norway rat)	Ipo11	XP_006231975.1
	IPO11	XP_001082924.2
Canis lupus familiaris (dog)	IPO11	XP_005617488.1
Xenopus tropicalis (tropical clawed frog)	ipo11	NP_001039123.1
Drosophila melanogaster (fruit fly)	Ranbp11	NP_788357.1
Neurospora crassa	NCU02069	XP_964596.2
Magnaporthe oryzae (rice blast fungus)	MGG_00744	XP_003718255.1
Homo sapiens (human)	IPO11	NP_001128251.1
Bos taurus (cattle)	LRRC70	NP_001179861.1
Mus musculus (house mouse)	Ipo11	NP_083941.2
Gallus gallus (chicken)	LRRC70	XP_004937324.1
Danio rerio (zebrafish)	zgc:91897	NP_001153133.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP002970	XP_311926.5
Arabidopsis thaliana (thale cress)	AT3G08960	NP_187508.5

Gene Ontology
Bibliography

Related articles in PubMed

Protecting PTEN in the Nucleus.

Whole-exome sequencing of muscle-invasive bladder cancer identifies recurrent copy number variation in IPO11 and prognostic significance of importin-11 overexpression on poor survival.
Zhao J, Xu W, He M, Zhang Z, Zeng S, Ma C, Sun Y, Xu C
Oncotarget7(46)75648-75658(2016 11)

Significant association between rare IPO11-HTR1A variants and attention deficit hyperactivity disorder in Caucasians.
Zuo L, Saba L, Lin X, Tan Y, Wang K, Krystal JH, Tabakoff B, Luo X
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics168(7)544-56(2015 Oct)

The ubiquitin-conjugating enzyme UBE2E3 and its import receptor importin-11 regulate the localization and activity of the antioxidant transcription factor NRF2.
Plafker KS, Plafker SM
Molecular biology of the cell26(2)327-38(2015 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

IPO11 provides protection in another way, the researchers found. The transport receptor also shuttles UBE2E1, an enzyme necessary for PTEN ubiquitination, into the nucleus. Thanks to IPO11, normal cells keep all of their UBE2E1 in the nucleus, allowing PTEN to continue functioning in the cytoplasm. In cells lacking IPO11, UBE2E1 remains in the cytoplasm and promotes the destruction of PTEN.
Title: Protecting PTEN in the Nucleus.

IPO11-HTR1A is a significant risk gene region for attention deficit hyperactivity disorder in Caucasians.
Title: Significant association between rare IPO11-HTR1A variants and attention deficit hyperactivity disorder in Caucasians.

Data indicate that ubiquitin-conjugating enzyme UBE2E3 and importin 11 (Imp-11)promote the nuclear accumulation and activity of transcription factor NF-E2 (Nrf2) by restricting the transcription factor from partitioning to the mitochondria
Title: The ubiquitin-conjugating enzyme UBE2E3 and its import receptor importin-11 regulate the localization and activity of the antioxidant transcription factor NRF2.

Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.

The following IPO11 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the IPO11 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu26120	NM_016338.4 Latest version!	Homo sapiens importin 11 (IPO11), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$475.30 $679.00
OHu26322	NM_001134779.1 Latest version!	Homo sapiens importin 11 (IPO11), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	20	$559.30 $799.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

IPO11 ( NM_016338.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_057422.3 Homo sapiens importin 11 (IPO11), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu26120
Clone ID Related Accession (Same CDS sequence)	NM_016338.4
Accession Version	NM_016338.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2928bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Homo sapiens(human)
Product	importin-11 isoform 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DA473424.1, BC033776.1, AF111109.1 and BM966917.1. On Sep 5, 2008 this sequence version replaced NM_016338.3. Transcript Variant: This variant (2) differs in the 5' UTR and uses a downstream translation initiation codon, compared to variant 1. The resulting isoform (2) is shorter at the N-terminus, compared to isoform 1. ##Evidence-Data-START## Transcript exon combination :: SRR1660809.190477.1, SRR1803616.158452.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGATCTCA ATAGTGCCAG CACTGTTGTT CTTCAGGTGT TAACACAGGC CACCAGTCAG 
GATACTGCTG TGTTAAAACC AGCTGAGGAG CAGTTGAAGC AGTGGGAGAC ACAGCCAGGT 
TTCTATTCAG TGTTGCTGAA TATTTTCACC AACCACACTT TGGATATAAA TGTAAGGTGG 
CTTGCTGTAC TGTATTTTAA ACATGGAATT GATCGCTACT GGAGACGTGT AGCACCTCAT 
GCTCTCTCAG AGGAGGAGAA AACTACTCTG CGTGCAGGGC TCATCACCAA CTTCAATGAA 
CCAATAAACC AGATTGCAAC TCAGATTGCA GTGCTCATTG CAAAAGTTGC TAGATTGGAT 
TGTCCCAGAC AGTGGCCTGA ACTAATTCCC ACTCTTATAG AGTCTGTTAA AGTCCAGGAT 
GATCTTCGAC AGCACAGAGC ATTACTTACC TTCTATCATG TTACCAAGAC ACTGGCATCT 
AAACGACTTG CTGCTGATAG AAAACTATTT TATGATTTAG CTTCTGGAAT TTATAATTTT 
GCCTGCTCTC TGTGGAATCA CCACACAGAC ACATTCCTGC AAGAAGTTTC TTCTGGCAAT 
GAAGCTGCAA TTTTGAGTTC ACTAGAACGA ACACTGCTAT CATTGAAAGT GCTGCGTAAG 
TTAACTGTTA ATGGATTTGT GGAACCTCAT AAGAATATGG AGGTGATGGG TTTTTTACAT 
GGAATATTTG AACGTCTAAA ACAGTTTCTG GAATGCAGTA GAAGTATAGG TACAGATAAT 
GTGTGTAGAG ATAGACTGGA AAAGACCATC ATTCTTTTTA CTAAAGTGCT TTTGGACTTC 
TTGGATCAGC ATCCTTTTTC ATTTACTCCT CTAATTCAGA GATCACTGGA ATTTTCTGTA 
AGCTATGTTT TTACAGAAGT TGGTGAAGGC GTTACATTTG AACGATTCAT TGTCCAATGT 
ATGAATCTTA TTAAGATGAT TGTCAAAAAT TATGCTTATA AGCCATCCAA AAATTTTGAA 
GATAGCAGCC CTGAAACTCT TGAAGCCCAT AAGATTAAGA TGGCATTCTT CACATATCCT 
ACTTTGACAG AGATATGTAG AAGATTAGTC TCTCATTATT TCCTATTAAC TGAAGAAGAA 
CTGACAATGT GGGAAGAAGA CCCAGAAGGC TTTACAGTGG AAGAAACAGG AGGAGATTCT 
TGGAAATATA GTTTGAGGCC ATGCACTGAA GTATTATTTA TAGATATATT CCATGAATAT 
AATCAGACTC TTACTCCTGT ACTTCTAGAA ATGATGCAAA CACTTCAAGG ACCCACAAAT 
GTGGAAGATA TGAATGCACT GTTAATCAAA GATGCTGTGT ATAATGCTGT TGGATTAGCT 
GCTTATGAGC TCTTTGACAG TGTTGATTTT GATCAGTGGT TTAAAAACCA GCTTCTTCCA 
GAATTACAAG TCATTCACAA TAGGTATAAG CCATTGCGAC GCAGGGTGAT TTGGCTCATC 
GGTCAGTGGA TTTCTGTGAA ATTCAAGTCT GACTTAAGAC CCATGCTTTA TGAAGCAATC 
TGTAACTTGC TTCAAGATCA AGATTTAGTG GTCCGTATTG AAACAGCTAC AACTTTGAAG 
TTAACTGTTG ATGATTTTGA ATTTAGAACA GATCAGTTTC TACCGTATTT GGAAACCATG 
TTCACACTAC TTTTTCAGTT ACTGCAGCAA GTTACAGAAT GTGACACAAA GATGCATGTT 
TTGCATGTCC TTTCTTGTGT GATCGAAAGA GTCAACATGC AGATACGACC ATATGTGGGA 
TGTTTGGTAC AATATTTGCC CCTCCTTTGG AAGCAGAGTG AAGAACACAA TATGTTGAGA 
TGTGCTATTT TGACAACACT TATTCATCTT GTTCAGGGAT TAGGAGCAGA CAGCAAGAAC 
CTGTACCCTT TCCTGCTCCC AGTTATTCAA CTGAGTACAG ATGTTTCACA GCCTCCACAT 
GTTTATCTTC TGGAAGATGG TTTAGAATTA TGGTTAGTAA CTTTGGAAAA CAGTCCATGT 
ATTACACCAG AGTTGCTTCG TATATTTCAG AATATGTCAC CACTTCTTGA ACTAAGTTCA 
GAAAATCTTA GAACTTGCTT TAAGATCATC AATGGTTATA TCTTTTTATC ATCAACAGAA 
TTTTTACAGA CATACGCAGT AGGTCTATGC CAGTCCTTTT GTGAACTTTT AAAGGAAATT 
ACTACAGAAG GTCAAGTTCA GGTGCTCAAG GTTGTGGAAA ATGCCCTTAA AGTGAACCCA 
ATACTAGGTC CACAAATGTT TCAACCGATT TTACCCTATG TTTTCAAGGG TATTATAGAA 
GGGGAGAGGT ATCCTGTAGT GATGTCCACG TATCTTGGAG TTATGGGTCG AGTTCTACTA 
CAAAACACTA GTTTTTTTTC TTCACTACTT AATGAGATGG CCCATAAATT TAATCAGGAG 
ATGGACCAGC TTTTGGGAAA TATGATTGAA ATGTGGGTTG ATCGAATGGA CAACATTACC 
CAGCCTGAAA GAAGAAAACT TTCAGCTTTG GCTTTGCTCT CTCTTCTGCC ATCTGATAAT 
AGTGTTATCC AAGATAAATT CTGTGGGATT ATAAACATTT CAGTAGAAGG CCTGCATGAT 
GTCATGACGG AAGATCCTGA AACAGGAACT TATAAAGACT GTATGTTGAT GTCTCATCTT 
GAGGAACCAA AAGTAACAGA AGATGAAGAA CCACCCACAG AACAAGATAA GAGGAAAAAG 
ATGCTGGCCC TGAAGGACCC TGTTCATACA GTGTCACTGC AGCAGTTCAT CTACGAGAAG 
CTCAAGGCAC AGCAGGAGAT GCTAGGAGAA CAAGGTTTCC AGTCCCTCAT GGAAACAGTG 
GATACGGAGA TTGTCACCCA GCTACAGGAG TTTTTGCAAG GATTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_057422.3
CDS	191..3118
Translation	MDLNSASTVVLQVLTQATSQDTAVLKPAEEQLKQWETQPGFYSVLLNIFTNHTLDINVRWLAVLYFKHGIDRYWRRVAPHALSEEEKTTLRAGLITNFNEPINQIATQIAVLIAKVARLDCPRQWPELIPTLIESVKVQDDLRQHRALLTFYHVTKTLASKRLAADRKLFYDLASGIYNFACSLWNHHTDTFLQEVSSGNEAAILSSLERTLLSLKVLRKLTVNGFVEPHKNMEVMGFLHGIFERLKQFLECSRSIGTDNVCRDRLEKTIILFTKVLLDFLDQHPFSFTPLIQRSLEFSVSYVFTEVGEGVTFERFIVQCMNLIKMIVKNYAYKPSKNFEDSSPETLEAHKIKMAFFTYPTLTEICRRLVSHYFLLTEEELTMWEEDPEGFTVEETGGDSWKYSLRPCTEVLFIDIFHEYNQTLTPVLLEMMQTLQGPTNVEDMNALLIKDAVYNAVGLAAYELFDSVDFDQWFKNQLLPELQVIHNRYKPLRRRVIWLIGQWISVKFKSDLRPMLYEAICNLLQDQDLVVRIETATTLKLTVDDFEFRTDQFLPYLETMFTLLFQLLQQVTECDTKMHVLHVLSCVIERVNMQIRPYVGCLVQYLPLLWKQSEEHNMLRCAILTTLIHLVQGLGADSKNLYPFLLPVIQLSTDVSQPPHVYLLEDGLELWLVTLENSPCITPELLRIFQNMSPLLELSSENLRTCFKIINGYIFLSSTEFLQTYAVGLCQSFCELLKEITTEGQVQVLKVVENALKVNPILGPQMFQPILPYVFKGIIEGERYPVVMSTYLGVMGRVLLQNTSFFSSLLNEMAHKFNQEMDQLLGNMIEMWVDRMDNITQPERRKLSALALLSLLPSDNSVIQDKFCGIINISVEGLHDVMTEDPETGTYKDCMLMSHLEEPKVTEDEEPPTEQDKRKKMLALKDPVHTVSLQQFIYEKLKAQQEMLGEQGFQSLMETVDTEIVTQLQEFLQGF

Target ORF information:

RefSeq Version	NM_016338.4
Organism	Homo sapiens(human)
Definition	Homo sapiens importin 11 (IPO11), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_016338.4

ORF Insert Sequence:

ATGGATCTCA ATAGTGCCAG CACTGTTGTT CTTCAGGTGT TAACACAGGC CACCAGTCAG 
GATACTGCTG TGTTAAAACC AGCTGAGGAG CAGTTGAAGC AGTGGGAGAC ACAGCCAGGT 
TTCTATTCAG TGTTGCTGAA TATTTTCACC AACCACACTT TGGATATAAA TGTAAGGTGG 
CTTGCTGTAC TGTATTTTAA ACATGGAATT GATCGCTACT GGAGACGTGT AGCACCTCAT 
GCTCTCTCAG AGGAGGAGAA AACTACTCTG CGTGCAGGGC TCATCACCAA CTTCAATGAA 
CCAATAAACC AGATTGCAAC TCAGATTGCA GTGCTCATTG CAAAAGTTGC TAGATTGGAT 
TGTCCCAGAC AGTGGCCTGA ACTAATTCCC ACTCTTATAG AGTCTGTTAA AGTCCAGGAT 
GATCTTCGAC AGCACAGAGC ATTACTTACC TTCTATCATG TTACCAAGAC ACTGGCATCT 
AAACGACTTG CTGCTGATAG AAAACTATTT TATGATTTAG CTTCTGGAAT TTATAATTTT 
GCCTGCTCTC TGTGGAATCA CCACACAGAC ACATTCCTGC AAGAAGTTTC TTCTGGCAAT 
GAAGCTGCAA TTTTGAGTTC ACTAGAACGA ACACTGCTAT CATTGAAAGT GCTGCGTAAG 
TTAACTGTTA ATGGATTTGT GGAACCTCAT AAGAATATGG AGGTGATGGG TTTTTTACAT 
GGAATATTTG AACGTCTAAA ACAGTTTCTG GAATGCAGTA GAAGTATAGG TACAGATAAT 
GTGTGTAGAG ATAGACTGGA AAAGACCATC ATTCTTTTTA CTAAAGTGCT TTTGGACTTC 
TTGGATCAGC ATCCTTTTTC ATTTACTCCT CTAATTCAGA GATCACTGGA ATTTTCTGTA 
AGCTATGTTT TTACAGAAGT TGGTGAAGGC GTTACATTTG AACGATTCAT TGTCCAATGT 
ATGAATCTTA TTAAGATGAT TGTCAAAAAT TATGCTTATA AGCCATCCAA AAATTTTGAA 
GATAGCAGCC CTGAAACTCT TGAAGCCCAT AAGATTAAGA TGGCATTCTT CACATATCCT 
ACTTTGACAG AGATATGTAG AAGATTAGTC TCTCATTATT TCCTATTAAC TGAAGAAGAA 
CTGACAATGT GGGAAGAAGA CCCAGAAGGC TTTACAGTGG AAGAAACAGG AGGAGATTCT 
TGGAAATATA GTTTGAGGCC ATGCACTGAA GTATTATTTA TAGATATATT CCATGAATAT 
AATCAGACTC TTACTCCTGT ACTTCTAGAA ATGATGCAAA CACTTCAAGG ACCCACAAAT 
GTGGAAGATA TGAATGCACT GTTAATCAAA GATGCTGTGT ATAATGCTGT TGGATTAGCT 
GCTTATGAGC TCTTTGACAG TGTTGATTTT GATCAGTGGT TTAAAAACCA GCTTCTTCCA 
GAATTACAAG TCATTCACAA TAGGTATAAG CCATTGCGAC GCAGGGTGAT TTGGCTCATC 
GGTCAGTGGA TTTCTGTGAA ATTCAAGTCT GACTTAAGAC CCATGCTTTA TGAAGCAATC 
TGTAACTTGC TTCAAGATCA AGATTTAGTG GTCCGTATTG AAACAGCTAC AACTTTGAAG 
TTAACTGTTG ATGATTTTGA ATTTAGAACA GATCAGTTTC TACCGTATTT GGAAACCATG 
TTCACACTAC TTTTTCAGTT ACTGCAGCAA GTTACAGAAT GTGACACAAA GATGCATGTT 
TTGCATGTCC TTTCTTGTGT GATCGAAAGA GTCAACATGC AGATACGACC ATATGTGGGA 
TGTTTGGTAC AATATTTGCC CCTCCTTTGG AAGCAGAGTG AAGAACACAA TATGTTGAGA 
TGTGCTATTT TGACAACACT TATTCATCTT GTTCAGGGAT TAGGAGCAGA CAGCAAGAAC 
CTGTACCCTT TCCTGCTCCC AGTTATTCAA CTGAGTACAG ATGTTTCACA GCCTCCACAT 
GTTTATCTTC TGGAAGATGG TTTAGAATTA TGGTTAGTAA CTTTGGAAAA CAGTCCATGT 
ATTACACCAG AGTTGCTTCG TATATTTCAG AATATGTCAC CACTTCTTGA ACTAAGTTCA 
GAAAATCTTA GAACTTGCTT TAAGATCATC AATGGTTATA TCTTTTTATC ATCAACAGAA 
TTTTTACAGA CATACGCAGT AGGTCTATGC CAGTCCTTTT GTGAACTTTT AAAGGAAATT 
ACTACAGAAG GTCAAGTTCA GGTGCTCAAG GTTGTGGAAA ATGCCCTTAA AGTGAACCCA 
ATACTAGGTC CACAAATGTT TCAACCGATT TTACCCTATG TTTTCAAGGG TATTATAGAA 
GGGGAGAGGT ATCCTGTAGT GATGTCCACG TATCTTGGAG TTATGGGTCG AGTTCTACTA 
CAAAACACTA GTTTTTTTTC TTCACTACTT AATGAGATGG CCCATAAATT TAATCAGGAG 
ATGGACCAGC TTTTGGGAAA TATGATTGAA ATGTGGGTTG ATCGAATGGA CAACATTACC 
CAGCCTGAAA GAAGAAAACT TTCAGCTTTG GCTTTGCTCT CTCTTCTGCC ATCTGATAAT 
AGTGTTATCC AAGATAAATT CTGTGGGATT ATAAACATTT CAGTAGAAGG CCTGCATGAT 
GTCATGACGG AAGATCCTGA AACAGGAACT TATAAAGACT GTATGTTGAT GTCTCATCTT 
GAGGAACCAA AAGTAACAGA AGATGAAGAA CCACCCACAG AACAAGATAA GAGGAAAAAG 
ATGCTGGCCC TGAAGGACCC TGTTCATACA GTGTCACTGC AGCAGTTCAT CTACGAGAAG 
CTCAAGGCAC AGCAGGAGAT GCTAGGAGAA CAAGGTTTCC AGTCCCTCAT GGAAACAGTG 
GATACGGAGA TTGTCACCCA GCTACAGGAG TTTTTGCAAG GATTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

IPO11 ( NM_001134779.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001128251.1 Homo sapiens importin 11 (IPO11), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu26322
Clone ID Related Accession (Same CDS sequence)	NM_001134779.1
Accession Version	NM_001134779.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3048bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-06-07
Organism	Homo sapiens(human)
Product	importin-11 isoform 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK302781.1, AF111109.1, BC033776.1 and BM966917.1. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). ##Evidence-Data-START## Transcript exon combination :: AK302781.1 [ECO:0000332] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGTACAGC CTATTATACA CTTGGGCTAT GTGGTATATA GCTTATTGTA TCTAGGCTAT 
AAGCCTGTAC AGCATGTTAC TGCACTGAAT ACTGTAAGCA GTTGTCACAA AATGGTTTCC 
ATGGATCTCA ATAGTGCCAG CACTGTTGTT CTTCAGGTGT TAACACAGGC CACCAGTCAG 
GATACTGCTG TGTTAAAACC AGCTGAGGAG CAGTTGAAGC AGTGGGAGAC ACAGCCAGGT 
TTCTATTCAG TGTTGCTGAA TATTTTCACC AACCACACTT TGGATATAAA TGTAAGGTGG 
CTTGCTGTAC TGTATTTTAA ACATGGAATT GATCGCTACT GGAGACGTGT AGCACCTCAT 
GCTCTCTCAG AGGAGGAGAA AACTACTCTG CGTGCAGGGC TCATCACCAA CTTCAATGAA 
CCAATAAACC AGATTGCAAC TCAGATTGCA GTGCTCATTG CAAAAGTTGC TAGATTGGAT 
TGTCCCAGAC AGTGGCCTGA ACTAATTCCC ACTCTTATAG AGTCTGTTAA AGTCCAGGAT 
GATCTTCGAC AGCACAGAGC ATTACTTACC TTCTATCATG TTACCAAGAC ACTGGCATCT 
AAACGACTTG CTGCTGATAG AAAACTATTT TATGATTTAG CTTCTGGAAT TTATAATTTT 
GCCTGCTCTC TGTGGAATCA CCACACAGAC ACATTCCTGC AAGAAGTTTC TTCTGGCAAT 
GAAGCTGCAA TTTTGAGTTC ACTAGAACGA ACACTGCTAT CATTGAAAGT GCTGCGTAAG 
TTAACTGTTA ATGGATTTGT GGAACCTCAT AAGAATATGG AGGTGATGGG TTTTTTACAT 
GGAATATTTG AACGTCTAAA ACAGTTTCTG GAATGCAGTA GAAGTATAGG TACAGATAAT 
GTGTGTAGAG ATAGACTGGA AAAGACCATC ATTCTTTTTA CTAAAGTGCT TTTGGACTTC 
TTGGATCAGC ATCCTTTTTC ATTTACTCCT CTAATTCAGA GATCACTGGA ATTTTCTGTA 
AGCTATGTTT TTACAGAAGT TGGTGAAGGC GTTACATTTG AACGATTCAT TGTCCAATGT 
ATGAATCTTA TTAAGATGAT TGTCAAAAAT TATGCTTATA AGCCATCCAA AAATTTTGAA 
GATAGCAGCC CTGAAACTCT TGAAGCCCAT AAGATTAAGA TGGCATTCTT CACATATCCT 
ACTTTGACAG AGATATGTAG AAGATTAGTC TCTCATTATT TCCTATTAAC TGAAGAAGAA 
CTGACAATGT GGGAAGAAGA CCCAGAAGGC TTTACAGTGG AAGAAACAGG AGGAGATTCT 
TGGAAATATA GTTTGAGGCC ATGCACTGAA GTATTATTTA TAGATATATT CCATGAATAT 
AATCAGACTC TTACTCCTGT ACTTCTAGAA ATGATGCAAA CACTTCAAGG ACCCACAAAT 
GTGGAAGATA TGAATGCACT GTTAATCAAA GATGCTGTGT ATAATGCTGT TGGATTAGCT 
GCTTATGAGC TCTTTGACAG TGTTGATTTT GATCAGTGGT TTAAAAACCA GCTTCTTCCA 
GAATTACAAG TCATTCACAA TAGGTATAAG CCATTGCGAC GCAGGGTGAT TTGGCTCATC 
GGTCAGTGGA TTTCTGTGAA ATTCAAGTCT GACTTAAGAC CCATGCTTTA TGAAGCAATC 
TGTAACTTGC TTCAAGATCA AGATTTAGTG GTCCGTATTG AAACAGCTAC AACTTTGAAG 
TTAACTGTTG ATGATTTTGA ATTTAGAACA GATCAGTTTC TACCGTATTT GGAAACCATG 
TTCACACTAC TTTTTCAGTT ACTGCAGCAA GTTACAGAAT GTGACACAAA GATGCATGTT 
TTGCATGTCC TTTCTTGTGT GATCGAAAGA GTCAACATGC AGATACGACC ATATGTGGGA 
TGTTTGGTAC AATATTTGCC CCTCCTTTGG AAGCAGAGTG AAGAACACAA TATGTTGAGA 
TGTGCTATTT TGACAACACT TATTCATCTT GTTCAGGGAT TAGGAGCAGA CAGCAAGAAC 
CTGTACCCTT TCCTGCTCCC AGTTATTCAA CTGAGTACAG ATGTTTCACA GCCTCCACAT 
GTTTATCTTC TGGAAGATGG TTTAGAATTA TGGTTAGTAA CTTTGGAAAA CAGTCCATGT 
ATTACACCAG AGTTGCTTCG TATATTTCAG AATATGTCAC CACTTCTTGA ACTAAGTTCA 
GAAAATCTTA GAACTTGCTT TAAGATCATC AATGGTTATA TCTTTTTATC ATCAACAGAA 
TTTTTACAGA CATACGCAGT AGGTCTATGC CAGTCCTTTT GTGAACTTTT AAAGGAAATT 
ACTACAGAAG GTCAAGTTCA GGTGCTCAAG GTTGTGGAAA ATGCCCTTAA AGTGAACCCA 
ATACTAGGTC CACAAATGTT TCAACCGATT TTACCCTATG TTTTCAAGGG TATTATAGAA 
GGGGAGAGGT ATCCTGTAGT GATGTCCACG TATCTTGGAG TTATGGGTCG AGTTCTACTA 
CAAAACACTA GTTTTTTTTC TTCACTACTT AATGAGATGG CCCATAAATT TAATCAGGAG 
ATGGACCAGC TTTTGGGAAA TATGATTGAA ATGTGGGTTG ATCGAATGGA CAACATTACC 
CAGCCTGAAA GAAGAAAACT TTCAGCTTTG GCTTTGCTCT CTCTTCTGCC ATCTGATAAT 
AGTGTTATCC AAGATAAATT CTGTGGGATT ATAAACATTT CAGTAGAAGG CCTGCATGAT 
GTCATGACGG AAGATCCTGA AACAGGAACT TATAAAGACT GTATGTTGAT GTCTCATCTT 
GAGGAACCAA AAGTAACAGA AGATGAAGAA CCACCCACAG AACAAGATAA GAGGAAAAAG 
ATGCTGGCCC TGAAGGACCC TGTTCATACA GTGTCACTGC AGCAGTTCAT CTACGAGAAG 
CTCAAGGCAC AGCAGGAGAT GCTAGGAGAA CAAGGTTTCC AGTCCCTCAT GGAAACAGTG 
GATACGGAGA TTGTCACCCA GCTACAGGAG TTTTTGCAAG GATTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001128251.1
CDS	131..3178
Translation	MVQPIIHLGYVVYSLLYLGYKPVQHVTALNTVSSCHKMVSMDLNSASTVVLQVLTQATSQDTAVLKPAEEQLKQWETQPGFYSVLLNIFTNHTLDINVRWLAVLYFKHGIDRYWRRVAPHALSEEEKTTLRAGLITNFNEPINQIATQIAVLIAKVARLDCPRQWPELIPTLIESVKVQDDLRQHRALLTFYHVTKTLASKRLAADRKLFYDLASGIYNFACSLWNHHTDTFLQEVSSGNEAAILSSLERTLLSLKVLRKLTVNGFVEPHKNMEVMGFLHGIFERLKQFLECSRSIGTDNVCRDRLEKTIILFTKVLLDFLDQHPFSFTPLIQRSLEFSVSYVFTEVGEGVTFERFIVQCMNLIKMIVKNYAYKPSKNFEDSSPETLEAHKIKMAFFTYPTLTEICRRLVSHYFLLTEEELTMWEEDPEGFTVEETGGDSWKYSLRPCTEVLFIDIFHEYNQTLTPVLLEMMQTLQGPTNVEDMNALLIKDAVYNAVGLAAYELFDSVDFDQWFKNQLLPELQVIHNRYKPLRRRVIWLIGQWISVKFKSDLRPMLYEAICNLLQDQDLVVRIETATTLKLTVDDFEFRTDQFLPYLETMFTLLFQLLQQVTECDTKMHVLHVLSCVIERVNMQIRPYVGCLVQYLPLLWKQSEEHNMLRCAILTTLIHLVQGLGADSKNLYPFLLPVIQLSTDVSQPPHVYLLEDGLELWLVTLENSPCITPELLRIFQNMSPLLELSSENLRTCFKIINGYIFLSSTEFLQTYAVGLCQSFCELLKEITTEGQVQVLKVVENALKVNPILGPQMFQPILPYVFKGIIEGERYPVVMSTYLGVMGRVLLQNTSFFSSLLNEMAHKFNQEMDQLLGNMIEMWVDRMDNITQPERRKLSALALLSLLPSDNSVIQDKFCGIINISVEGLHDVMTEDPETGTYKDCMLMSHLEEPKVTEDEEPPTEQDKRKKMLALKDPVHTVSLQQFIYEKLKAQQEMLGEQGFQSLMETVDTEIVTQLQEFLQGF

Target ORF information:

RefSeq Version	NM_001134779.1
Organism	Homo sapiens(human)
Definition	Homo sapiens importin 11 (IPO11), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001134779.1

ORF Insert Sequence:

ATGGTACAGC CTATTATACA CTTGGGCTAT GTGGTATATA GCTTATTGTA TCTAGGCTAT 
AAGCCTGTAC AGCATGTTAC TGCACTGAAT ACTGTAAGCA GTTGTCACAA AATGGTTTCC 
ATGGATCTCA ATAGTGCCAG CACTGTTGTT CTTCAGGTGT TAACACAGGC CACCAGTCAG 
GATACTGCTG TGTTAAAACC AGCTGAGGAG CAGTTGAAGC AGTGGGAGAC ACAGCCAGGT 
TTCTATTCAG TGTTGCTGAA TATTTTCACC AACCACACTT TGGATATAAA TGTAAGGTGG 
CTTGCTGTAC TGTATTTTAA ACATGGAATT GATCGCTACT GGAGACGTGT AGCACCTCAT 
GCTCTCTCAG AGGAGGAGAA AACTACTCTG CGTGCAGGGC TCATCACCAA CTTCAATGAA 
CCAATAAACC AGATTGCAAC TCAGATTGCA GTGCTCATTG CAAAAGTTGC TAGATTGGAT 
TGTCCCAGAC AGTGGCCTGA ACTAATTCCC ACTCTTATAG AGTCTGTTAA AGTCCAGGAT 
GATCTTCGAC AGCACAGAGC ATTACTTACC TTCTATCATG TTACCAAGAC ACTGGCATCT 
AAACGACTTG CTGCTGATAG AAAACTATTT TATGATTTAG CTTCTGGAAT TTATAATTTT 
GCCTGCTCTC TGTGGAATCA CCACACAGAC ACATTCCTGC AAGAAGTTTC TTCTGGCAAT 
GAAGCTGCAA TTTTGAGTTC ACTAGAACGA ACACTGCTAT CATTGAAAGT GCTGCGTAAG 
TTAACTGTTA ATGGATTTGT GGAACCTCAT AAGAATATGG AGGTGATGGG TTTTTTACAT 
GGAATATTTG AACGTCTAAA ACAGTTTCTG GAATGCAGTA GAAGTATAGG TACAGATAAT 
GTGTGTAGAG ATAGACTGGA AAAGACCATC ATTCTTTTTA CTAAAGTGCT TTTGGACTTC 
TTGGATCAGC ATCCTTTTTC ATTTACTCCT CTAATTCAGA GATCACTGGA ATTTTCTGTA 
AGCTATGTTT TTACAGAAGT TGGTGAAGGC GTTACATTTG AACGATTCAT TGTCCAATGT 
ATGAATCTTA TTAAGATGAT TGTCAAAAAT TATGCTTATA AGCCATCCAA AAATTTTGAA 
GATAGCAGCC CTGAAACTCT TGAAGCCCAT AAGATTAAGA TGGCATTCTT CACATATCCT 
ACTTTGACAG AGATATGTAG AAGATTAGTC TCTCATTATT TCCTATTAAC TGAAGAAGAA 
CTGACAATGT GGGAAGAAGA CCCAGAAGGC TTTACAGTGG AAGAAACAGG AGGAGATTCT 
TGGAAATATA GTTTGAGGCC ATGCACTGAA GTATTATTTA TAGATATATT CCATGAATAT 
AATCAGACTC TTACTCCTGT ACTTCTAGAA ATGATGCAAA CACTTCAAGG ACCCACAAAT 
GTGGAAGATA TGAATGCACT GTTAATCAAA GATGCTGTGT ATAATGCTGT TGGATTAGCT 
GCTTATGAGC TCTTTGACAG TGTTGATTTT GATCAGTGGT TTAAAAACCA GCTTCTTCCA 
GAATTACAAG TCATTCACAA TAGGTATAAG CCATTGCGAC GCAGGGTGAT TTGGCTCATC 
GGTCAGTGGA TTTCTGTGAA ATTCAAGTCT GACTTAAGAC CCATGCTTTA TGAAGCAATC 
TGTAACTTGC TTCAAGATCA AGATTTAGTG GTCCGTATTG AAACAGCTAC AACTTTGAAG 
TTAACTGTTG ATGATTTTGA ATTTAGAACA GATCAGTTTC TACCGTATTT GGAAACCATG 
TTCACACTAC TTTTTCAGTT ACTGCAGCAA GTTACAGAAT GTGACACAAA GATGCATGTT 
TTGCATGTCC TTTCTTGTGT GATCGAAAGA GTCAACATGC AGATACGACC ATATGTGGGA 
TGTTTGGTAC AATATTTGCC CCTCCTTTGG AAGCAGAGTG AAGAACACAA TATGTTGAGA 
TGTGCTATTT TGACAACACT TATTCATCTT GTTCAGGGAT TAGGAGCAGA CAGCAAGAAC 
CTGTACCCTT TCCTGCTCCC AGTTATTCAA CTGAGTACAG ATGTTTCACA GCCTCCACAT 
GTTTATCTTC TGGAAGATGG TTTAGAATTA TGGTTAGTAA CTTTGGAAAA CAGTCCATGT 
ATTACACCAG AGTTGCTTCG TATATTTCAG AATATGTCAC CACTTCTTGA ACTAAGTTCA 
GAAAATCTTA GAACTTGCTT TAAGATCATC AATGGTTATA TCTTTTTATC ATCAACAGAA 
TTTTTACAGA CATACGCAGT AGGTCTATGC CAGTCCTTTT GTGAACTTTT AAAGGAAATT 
ACTACAGAAG GTCAAGTTCA GGTGCTCAAG GTTGTGGAAA ATGCCCTTAA AGTGAACCCA 
ATACTAGGTC CACAAATGTT TCAACCGATT TTACCCTATG TTTTCAAGGG TATTATAGAA 
GGGGAGAGGT ATCCTGTAGT GATGTCCACG TATCTTGGAG TTATGGGTCG AGTTCTACTA 
CAAAACACTA GTTTTTTTTC TTCACTACTT AATGAGATGG CCCATAAATT TAATCAGGAG 
ATGGACCAGC TTTTGGGAAA TATGATTGAA ATGTGGGTTG ATCGAATGGA CAACATTACC 
CAGCCTGAAA GAAGAAAACT TTCAGCTTTG GCTTTGCTCT CTCTTCTGCC ATCTGATAAT 
AGTGTTATCC AAGATAAATT CTGTGGGATT ATAAACATTT CAGTAGAAGG CCTGCATGAT 
GTCATGACGG AAGATCCTGA AACAGGAACT TATAAAGACT GTATGTTGAT GTCTCATCTT 
GAGGAACCAA AAGTAACAGA AGATGAAGAA CCACCCACAG AACAAGATAA GAGGAAAAAG 
ATGCTGGCCC TGAAGGACCC TGTTCATACA GTGTCACTGC AGCAGTTCAT CTACGAGAAG 
CTCAAGGCAC AGCAGGAGAT GCTAGGAGAA CAAGGTTTCC AGTCCCTCAT GGAAACAGTG 
GATACGGAGA TTGTCACCCA GCTACAGGAG TTTTTGCAAG GATTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Protecting PTEN in the Nucleus.
Cancer discovery7(4)OF1(2017 04)

Whole-exome sequencing of muscle-invasive bladder cancer identifies recurrent copy number variation in IPO11 and prognostic significance of importin-11 overexpression on poor survival.
Oncotarget7(46)75648-75658(2016 11)
Zhao J,Xu W,He M,Zhang Z,Zeng S,Ma C,Sun Y,Xu C

Significant association between rare IPO11-HTR1A variants and attention deficit hyperactivity disorder in Caucasians.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics168(7)544-56(2015 Oct)
Zuo L,Saba L,Lin X,Tan Y,Wang K,Krystal JH,Tabakoff B,Luo X

The ubiquitin-conjugating enzyme UBE2E3 and its import receptor importin-11 regulate the localization and activity of the antioxidant transcription factor NRF2.
Molecular biology of the cell26(2)327-38(2015 Jan)
Plafker KS,Plafker SM

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IPO11 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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