PLEKHO1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	PLEKHO1
Entrez Gene ID	51177
Full Name	pleckstrin homology domain containing O1
Synonyms	CKIP-1,CKIP1,JBP,OC120
General protein information	Preferred Names pleckstrin homology domain containing O1 Names pleckstrin homology domain-containing family O member 1 C-Jun-binding protein CK2 interacting protein 1; HQ0024c protein CK2-interacting protein 1 PH domain-containing family O member 1 casein kinase 2-interacting protein 1 osteoclast maturation-associated gene 120 protein
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1q21.2
Disorder MIM:	608335

mRNA and Protein(s)

mRNA	Protein	Name
XM_024447478.1	XP_024303246.1	pleckstrin homology domain-containing family O member 1 isoform X1
NM_001304723.1	NP_001291652.1	pleckstrin homology domain-containing family O member 1 isoform b
NM_001304722.1	NP_001291651.1	pleckstrin homology domain-containing family O member 1 isoform b
NM_016274.5	NP_057358.2	pleckstrin homology domain-containing family O member 1 isoform a
XM_017001420.1	XP_016856909.1	pleckstrin homology domain-containing family O member 1 isoform X1
XM_017001420.2	XP_016856909.1	pleckstrin homology domain-containing family O member 1 isoform X2
NM_016274.6	NP_057358.2	pleckstrin homology domain-containing family O member 1 isoform a
NM_001304724.1	NP_001291653.1	pleckstrin homology domain-containing family O member 1 isoform c

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	PLEKHO1	XP_513771.2
Rattus norvegicus (Norway rat)	Plekho1	NP_001020290.1
Canis lupus familiaris (dog)	PLEKHO1	XP_849847.1
Mus musculus (house mouse)	Plekho1	NP_075809.1
Gallus gallus (chicken)	PLEKHO1	NP_001026527.1
Xenopus tropicalis (tropical clawed frog)	plekho1	XP_004917395.1
Homo sapiens (human)	PLEKHO1	NP_057358.2
Bos taurus (cattle)	PLEKHO1	NP_001077266.1
Danio rerio (zebrafish)	LOC562940	XP_691398.3
	PLEKHO1	XP_001098879.2

Gene Ontology
Bibliography

Related articles in PubMed

Association of CKIP-1 P21A polymorphism with risk of chronic heart failure in a Chinese population.
Li MP, Zhang YJ, Hu XL, Zhou JP, Yang YL, Peng LM, Qi H, Yang TL, Chen XP
Oncotarget8(22)36545-36552(2017 May)

A novel role of CKIP-1 in promoting megakaryocytic differentiation.
Fan J, Wang Y, Shen Y, Liu Q, Gao R, Qiu Y, Wang C, Zhang L
Oncotarget8(18)30138-30150(2017 May)

Casein Kinase 2 Interacting Protein-1 regulates M1 and M2 inflammatory macrophage polarization.
Chen Y, Liu W, Wang Y, Zhang L, Wei J, Zhang X, He F, Zhang L
Cellular signalling33107-121(2017 May)

Increased PLEKHO1 within osteoblasts suppresses Smad-dependent BMP signaling to inhibit bone formation during aging.
Liu J, Liang C, Guo B, Wu X, Li D, Zhang Z, Zheng K, Dang L, He X, Lu C, Peng S, Pan X, Zhang BT, Lu A, Zhang G
Aging cell16(2)360-376(2017 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

these data integrated CKIP-1 expression and function as a novel transcriptional regulator of macrophage polarization.
Title: Casein Kinase 2 Interacting Protein-1 regulates M1 and M2 inflammatory macrophage polarization.

the increased PLEKHO1 could suppress Smad-dependent BMP signaling to inhibit bone formation during aging.
Title: Increased PLEKHO1 within osteoblasts suppresses Smad-dependent BMP signaling to inhibit bone formation during aging.

New light on the molecular mechanism of cell adhesion-mediated drug resistance in Non-Hodgkin's Lymphoma (NHL) and targeting CKIP-1 may be a novel therapeutic target for NHL.
Title: Silencing of CKIP-1 promotes tumor proliferation and cell adhesion-mediated drug resistance via regulating AKT activity in non-Hodgkin's lymphoma.

There is a major role of the CK2alpha-interacting protein CKIP-1 in activation of PAK1 for neoplastic prostate cells transformation.
Title: The Role of the Pleckstrin Homology Domain-containing Protein CKIP-1 in Activation of p21-activated Kinase 1 (PAK1).

High expression levels of CKIP1 were associated with the development of lung cancer, and that CKIP1 knockdown may block tumor cell growth mainly by promoting cell apoptosis.
Title: Role of the CKIP1 gene in proliferation and apoptosis of the human lung cancer cell line H1299.

The following PLEKHO1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PLEKHO1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu14004	NM_016274.6 Latest version!	Homo sapiens pleckstrin homology domain containing O1 (PLEKHO1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
OHu67740	NM_001304723.1 Latest version!	Homo sapiens pleckstrin homology domain containing O1 (PLEKHO1), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$139.30 $199.00
OHu67740	NM_001304722.1 Latest version!	Homo sapiens pleckstrin homology domain containing O1 (PLEKHO1), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$139.30 $199.00
OHu67741	NM_001304724.1 Latest version!	Homo sapiens pleckstrin homology domain containing O1 (PLEKHO1), transcript variant 4, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$139.30 $199.00
OHu67740	XM_017001420.2 Latest version!	Homo sapiens pleckstrin homology domain containing O1 (PLEKHO1), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$139.30 $199.00
OHu105060	XM_024447478.1 Latest version!	Homo sapiens pleckstrin homology domain containing O1 (PLEKHO1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
View Old Accession Versions >>
OHu67740	XM_017001420.1	Homo sapiens pleckstrin homology domain containing O1 (PLEKHO1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$139.30 $199.00
OHu14004	NM_016274.5	Homo sapiens pleckstrin homology domain containing O1 (PLEKHO1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

PLEKHO1 ( NM_016274.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_057358.2 Homo sapiens pleckstrin homology domain containing O1 (PLEKHO1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu14004
Clone ID Related Accession (Same CDS sequence)	NM_016274.5 , NM_016274.6
Accession Version	NM_016274.5	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1230bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-05
Organism	Homo sapiens(human)
Product	pleckstrin homology domain-containing family O member 1 isoform a
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from HY006501.1, AF192912.1 and AK025937.1. On Feb 5, 2015 this sequence version replaced NM_016274.4. Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163658.86881.1, SRR1163657.272322.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGATGAAGA AGAACAATTC CGCCAAGCGG GGACCTCAGG ATGGAAACCA GCAGCCTGCA 
CCGCCCGAGA AGGTCGGCTG GGTCCGGAAA TTCTGCGGGA AAGGGATTTT CAGGGAGATT 
TGGAAAAACC GCTATGTGGT GCTGAAAGGG GACCAGCTCT ACATCTCTGA GAAGGAGGTA 
AAAGATGAGA AAAATATTCA AGAGGTATTT GACCTGAGTG ACTATGAGAA GTGTGAAGAG 
CTCCGGAAGT CCAAGAGCAG GAGCAAGAAA AATCATAGCA AGTTTACTCT TGCCCACTCC 
AAACAGCCCG GTAACACGGC ACCCAACCTG ATCTTCCTGG CAGTGAGTCC AGAAGAGAAG 
GAATCGTGGA TCAATGCCCT CAACTCTGCC ATCACCCGAG CCAAGAACCG TATCTTGGAT 
GAGGTCACCG TTGAGGAGGA CAGCTATCTT GCCCATCCCA CTCGAGACAG GGCAAAAATC 
CAGCACTCCC GCCGCCCCCC AACAAGGGGA CACCTAATGG CTGTGGCTTC CACCTCTACC 
TCGGATGGGA TGCTGACCTT GGACTTGATC CAAGAGGAAG ACCCTTCCCC TGAGGAACCA 
ACCTCTTGTG CTGAGAGCTT TCGGGTTGAC CTGGACAAGT CTGTGGCCCA GCTGGCAGGG 
AGCCGGCGGA GAGCGGACTC AGACCGCATC CAGCCCTCCG CAGACCGGGC AAGCAGTCTC 
TCCCGACCTT GGGAAAAAAC AGACAAAGGG GCCACCTACA CCCCCCAGGC ACCCAAGAAG 
TTGACGCCCA CAGAGAAAGG CCGCTGCGCC TCCCTGGAGG AGATCCTATC TCAGCGGGAT 
GCTGCCTCTG CCCGCACCCT CCAGCTGCGG GCTGAGGAAC CCCCAACCCC TGCCCTCCCC 
AACCCGGGGC AGCTGTCCCG GATCCAGGAC CTGGTAGCAA GGAAACTGGA GGAGACTCAG 
GAGCTTCTGG CAGAGGTTCA GGGACTGGGA GATGGGAAGC GAAAGGCCAA GGACCCCCCT 
CGGTCTCCGC CGGATTCTGA GTCAGAGCAG CTGCTGCTGG AGACGGAACG GCTGCTGGGA 
GAGGCATCAT CGAATTGGAG CCAGGCAAAG AGGGTGCTGC AGGAGGTCAG GGAGCTGAGA 
GACCTGTACA GACAGATGGA CCTGCAGACC CCGGACTCCC ACCTCAGACA GACCACCCCG 
CACAGTCAGT ACCGGAAGAG CCTGATGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_057358.2
CDS	357..1586
Translation	MMKKNNSAKRGPQDGNQQPAPPEKVGWVRKFCGKGIFREIWKNRYVVLKGDQLYISEKEVKDEKNIQEVFDLSDYEKCEELRKSKSRSKKNHSKFTLAHSKQPGNTAPNLIFLAVSPEEKESWINALNSAITRAKNRILDEVTVEEDSYLAHPTRDRAKIQHSRRPPTRGHLMAVASTSTSDGMLTLDLIQEEDPSPEEPTSCAESFRVDLDKSVAQLAGSRRRADSDRIQPSADRASSLSRPWEKTDKGATYTPQAPKKLTPTEKGRCASLEEILSQRDAASARTLQLRAEEPPTPALPNPGQLSRIQDLVARKLEETQELLAEVQGLGDGKRKAKDPPRSPPDSESEQLLLETERLLGEASSNWSQAKRVLQEVRELRDLYRQMDLQTPDSHLRQTTPHSQYRKSLM

Target ORF information:

RefSeq Version	NM_016274.5
Organism	Homo sapiens(human)
Definition	Homo sapiens pleckstrin homology domain containing O1 (PLEKHO1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_016274.5

ORF Insert Sequence:

ATGATGAAGA AGAACAATTC CGCCAAGCGG GGACCTCAGG ATGGAAACCA GCAGCCTGCA 
CCGCCCGAGA AGGTCGGCTG GGTCCGGAAA TTCTGCGGGA AAGGGATTTT CAGGGAGATT 
TGGAAAAACC GCTATGTGGT GCTGAAAGGG GACCAGCTCT ACATCTCTGA GAAGGAGGTA 
AAAGATGAGA AAAATATTCA AGAGGTATTT GACCTGAGTG ACTATGAGAA GTGTGAAGAG 
CTCCGGAAGT CCAAGAGCAG GAGCAAGAAA AATCATAGCA AGTTTACTCT TGCCCACTCC 
AAACAGCCCG GTAACACGGC ACCCAACCTG ATCTTCCTGG CAGTGAGTCC AGAAGAGAAG 
GAATCGTGGA TCAATGCCCT CAACTCTGCC ATCACCCGAG CCAAGAACCG TATCTTGGAT 
GAGGTCACCG TTGAGGAGGA CAGCTATCTT GCCCATCCCA CTCGAGACAG GGCAAAAATC 
CAGCACTCCC GCCGCCCCCC AACAAGGGGA CACCTAATGG CTGTGGCTTC CACCTCTACC 
TCGGATGGGA TGCTGACCTT GGACTTGATC CAAGAGGAAG ACCCTTCCCC TGAGGAACCA 
ACCTCTTGTG CTGAGAGCTT TCGGGTTGAC CTGGACAAGT CTGTGGCCCA GCTGGCAGGG 
AGCCGGCGGA GAGCGGACTC AGACCGCATC CAGCCCTCCG CAGACCGGGC AAGCAGTCTC 
TCCCGACCTT GGGAAAAAAC AGACAAAGGG GCCACCTACA CCCCCCAGGC ACCCAAGAAG 
TTGACGCCCA CAGAGAAAGG CCGCTGCGCC TCCCTGGAGG AGATCCTATC TCAGCGGGAT 
GCTGCCTCTG CCCGCACCCT CCAGCTGCGG GCTGAGGAAC CCCCAACCCC TGCCCTCCCC 
AACCCGGGGC AGCTGTCCCG GATCCAGGAC CTGGTAGCAA GGAAACTGGA GGAGACTCAG 
GAGCTTCTGG CAGAGGTTCA GGGACTGGGA GATGGGAAGC GAAAGGCCAA GGACCCCCCT 
CGGTCTCCGC CGGATTCTGA GTCAGAGCAG CTGCTGCTGG AGACGGAACG GCTGCTGGGA 
GAGGCATCAT CGAATTGGAG CCAGGCAAAG AGGGTGCTGC AGGAGGTCAG GGAGCTGAGA 
GACCTGTACA GACAGATGGA CCTGCAGACC CCGGACTCCC ACCTCAGACA GACCACCCCG 
CACAGTCAGT ACCGGAAGAG CCTGATGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PLEKHO1 ( NM_016274.6 ) cDNA ORF clone, Homo sapiens(human) -> NP_057358.2 Homo sapiens pleckstrin homology domain containing O1 (PLEKHO1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu14004
Clone ID Related Accession (Same CDS sequence)	NM_016274.5 , NM_016274.6
Accession Version	NM_016274.6 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1230bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-07
Organism	Homo sapiens(human)
Product	pleckstrin homology domain-containing family O member 1 isoform a
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from HY006501.1, AF192912.1 and AK025937.1. On Nov 22, 2018 this sequence version replaced NM_016274.5. Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163658.86881.1, SRR1163657.272322.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000369124.5/ ENSP00000358120.4 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGATGAAGA AGAACAATTC CGCCAAGCGG GGACCTCAGG ATGGAAACCA GCAGCCTGCA 
CCGCCCGAGA AGGTCGGCTG GGTCCGGAAA TTCTGCGGGA AAGGGATTTT CAGGGAGATT 
TGGAAAAACC GCTATGTGGT GCTGAAAGGG GACCAGCTCT ACATCTCTGA GAAGGAGGTA 
AAAGATGAGA AAAATATTCA AGAGGTATTT GACCTGAGTG ACTATGAGAA GTGTGAAGAG 
CTCCGGAAGT CCAAGAGCAG GAGCAAGAAA AATCATAGCA AGTTTACTCT TGCCCACTCC 
AAACAGCCCG GTAACACGGC ACCCAACCTG ATCTTCCTGG CAGTGAGTCC AGAAGAGAAG 
GAATCGTGGA TCAATGCCCT CAACTCTGCC ATCACCCGAG CCAAGAACCG TATCTTGGAT 
GAGGTCACCG TTGAGGAGGA CAGCTATCTT GCCCATCCCA CTCGAGACAG GGCAAAAATC 
CAGCACTCCC GCCGCCCCCC AACAAGGGGA CACCTAATGG CTGTGGCTTC CACCTCTACC 
TCGGATGGGA TGCTGACCTT GGACTTGATC CAAGAGGAAG ACCCTTCCCC TGAGGAACCA 
ACCTCTTGTG CTGAGAGCTT TCGGGTTGAC CTGGACAAGT CTGTGGCCCA GCTGGCAGGG 
AGCCGGCGGA GAGCGGACTC AGACCGCATC CAGCCCTCCG CAGACCGGGC AAGCAGTCTC 
TCCCGACCTT GGGAAAAAAC AGACAAAGGG GCCACCTACA CCCCCCAGGC ACCCAAGAAG 
TTGACGCCCA CAGAGAAAGG CCGCTGCGCC TCCCTGGAGG AGATCCTATC TCAGCGGGAT 
GCTGCCTCTG CCCGCACCCT CCAGCTGCGG GCTGAGGAAC CCCCAACCCC TGCCCTCCCC 
AACCCGGGGC AGCTGTCCCG GATCCAGGAC CTGGTAGCAA GGAAACTGGA GGAGACTCAG 
GAGCTTCTGG CAGAGGTTCA GGGACTGGGA GATGGGAAGC GAAAGGCCAA GGACCCCCCT 
CGGTCTCCGC CGGATTCTGA GTCAGAGCAG CTGCTGCTGG AGACGGAACG GCTGCTGGGA 
GAGGCATCAT CGAATTGGAG CCAGGCAAAG AGGGTGCTGC AGGAGGTCAG GGAGCTGAGA 
GACCTGTACA GACAGATGGA CCTGCAGACC CCGGACTCCC ACCTCAGACA GACCACCCCG 
CACAGTCAGT ACCGGAAGAG CCTGATGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_057358.2
CDS	343..1572
Translation	MMKKNNSAKRGPQDGNQQPAPPEKVGWVRKFCGKGIFREIWKNRYVVLKGDQLYISEKEVKDEKNIQEVFDLSDYEKCEELRKSKSRSKKNHSKFTLAHSKQPGNTAPNLIFLAVSPEEKESWINALNSAITRAKNRILDEVTVEEDSYLAHPTRDRAKIQHSRRPPTRGHLMAVASTSTSDGMLTLDLIQEEDPSPEEPTSCAESFRVDLDKSVAQLAGSRRRADSDRIQPSADRASSLSRPWEKTDKGATYTPQAPKKLTPTEKGRCASLEEILSQRDAASARTLQLRAEEPPTPALPNPGQLSRIQDLVARKLEETQELLAEVQGLGDGKRKAKDPPRSPPDSESEQLLLETERLLGEASSNWSQAKRVLQEVRELRDLYRQMDLQTPDSHLRQTTPHSQYRKSLM

Target ORF information:

RefSeq Version	NM_016274.6
Organism	Homo sapiens(human)
Definition	Homo sapiens pleckstrin homology domain containing O1 (PLEKHO1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_016274.6

ORF Insert Sequence:

ATGATGAAGA AGAACAATTC CGCCAAGCGG GGACCTCAGG ATGGAAACCA GCAGCCTGCA 
CCGCCCGAGA AGGTCGGCTG GGTCCGGAAA TTCTGCGGGA AAGGGATTTT CAGGGAGATT 
TGGAAAAACC GCTATGTGGT GCTGAAAGGG GACCAGCTCT ACATCTCTGA GAAGGAGGTA 
AAAGATGAGA AAAATATTCA AGAGGTATTT GACCTGAGTG ACTATGAGAA GTGTGAAGAG 
CTCCGGAAGT CCAAGAGCAG GAGCAAGAAA AATCATAGCA AGTTTACTCT TGCCCACTCC 
AAACAGCCCG GTAACACGGC ACCCAACCTG ATCTTCCTGG CAGTGAGTCC AGAAGAGAAG 
GAATCGTGGA TCAATGCCCT CAACTCTGCC ATCACCCGAG CCAAGAACCG TATCTTGGAT 
GAGGTCACCG TTGAGGAGGA CAGCTATCTT GCCCATCCCA CTCGAGACAG GGCAAAAATC 
CAGCACTCCC GCCGCCCCCC AACAAGGGGA CACCTAATGG CTGTGGCTTC CACCTCTACC 
TCGGATGGGA TGCTGACCTT GGACTTGATC CAAGAGGAAG ACCCTTCCCC TGAGGAACCA 
ACCTCTTGTG CTGAGAGCTT TCGGGTTGAC CTGGACAAGT CTGTGGCCCA GCTGGCAGGG 
AGCCGGCGGA GAGCGGACTC AGACCGCATC CAGCCCTCCG CAGACCGGGC AAGCAGTCTC 
TCCCGACCTT GGGAAAAAAC AGACAAAGGG GCCACCTACA CCCCCCAGGC ACCCAAGAAG 
TTGACGCCCA CAGAGAAAGG CCGCTGCGCC TCCCTGGAGG AGATCCTATC TCAGCGGGAT 
GCTGCCTCTG CCCGCACCCT CCAGCTGCGG GCTGAGGAAC CCCCAACCCC TGCCCTCCCC 
AACCCGGGGC AGCTGTCCCG GATCCAGGAC CTGGTAGCAA GGAAACTGGA GGAGACTCAG 
GAGCTTCTGG CAGAGGTTCA GGGACTGGGA GATGGGAAGC GAAAGGCCAA GGACCCCCCT 
CGGTCTCCGC CGGATTCTGA GTCAGAGCAG CTGCTGCTGG AGACGGAACG GCTGCTGGGA 
GAGGCATCAT CGAATTGGAG CCAGGCAAAG AGGGTGCTGC AGGAGGTCAG GGAGCTGAGA 
GACCTGTACA GACAGATGGA CCTGCAGACC CCGGACTCCC ACCTCAGACA GACCACCCCG 
CACAGTCAGT ACCGGAAGAG CCTGATGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PLEKHO1 ( NM_001304723.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001291652.1 Homo sapiens pleckstrin homology domain containing O1 (PLEKHO1), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu67740
Clone ID Related Accession (Same CDS sequence)	NM_001304723.1 , NM_001304722.1 , XM_017001420.1 , XM_017001420.2
Accession Version	NM_001304723.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 714bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-07
Organism	Homo sapiens(human)
Product	pleckstrin homology domain-containing family O member 1 isoform b
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DB023901.1, BP329810.1, AF192912.1 and AK025937.1. Transcript Variant: This variant (3) lacks the first exon and retains intronic sequence at the 5' end compared to variant 1, which causes translation initiation at a downstream AUG. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2 and 3 both encode the same isoform (b). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163655.557404.1, SRR1163657.502964.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCTGTGG CTTCCACCTC TACCTCGGAT GGGATGCTGA CCTTGGACTT GATCCAAGAG 
GAAGACCCTT CCCCTGAGGA ACCAACCTCT TGTGCTGAGA GCTTTCGGGT TGACCTGGAC 
AAGTCTGTGG CCCAGCTGGC AGGGAGCCGG CGGAGAGCGG ACTCAGACCG CATCCAGCCC 
TCCGCAGACC GGGCAAGCAG TCTCTCCCGA CCTTGGGAAA AAACAGACAA AGGGGCCACC 
TACACCCCCC AGGCACCCAA GAAGTTGACG CCCACAGAGA AAGGCCGCTG CGCCTCCCTG 
GAGGAGATCC TATCTCAGCG GGATGCTGCC TCTGCCCGCA CCCTCCAGCT GCGGGCTGAG 
GAACCCCCAA CCCCTGCCCT CCCCAACCCG GGGCAGCTGT CCCGGATCCA GGACCTGGTA 
GCAAGGAAAC TGGAGGAGAC TCAGGAGCTT CTGGCAGAGG TTCAGGGACT GGGAGATGGG 
AAGCGAAAGG CCAAGGACCC CCCTCGGTCT CCGCCGGATT CTGAGTCAGA GCAGCTGCTG 
CTGGAGACGG AACGGCTGCT GGGAGAGGCA TCATCGAATT GGAGCCAGGC AAAGAGGGTG 
CTGCAGGAGG TCAGGGAGCT GAGAGACCTG TACAGACAGA TGGACCTGCA GACCCCGGAC 
TCCCACCTCA GACAGACCAC CCCGCACAGT CAGTACCGGA AGAGCCTGAT GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001291652.1
CDS	813..1526
Translation	MAVASTSTSDGMLTLDLIQEEDPSPEEPTSCAESFRVDLDKSVAQLAGSRRRADSDRIQPSADRASSLSRPWEKTDKGATYTPQAPKKLTPTEKGRCASLEEILSQRDAASARTLQLRAEEPPTPALPNPGQLSRIQDLVARKLEETQELLAEVQGLGDGKRKAKDPPRSPPDSESEQLLLETERLLGEASSNWSQAKRVLQEVRELRDLYRQMDLQTPDSHLRQTTPHSQYRKSLM

Target ORF information:

RefSeq Version	NM_001304723.1
Organism	Homo sapiens(human)
Definition	Homo sapiens pleckstrin homology domain containing O1 (PLEKHO1), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001304723.1

ORF Insert Sequence:

ATGGCTGTGG CTTCCACCTC TACCTCGGAT GGGATGCTGA CCTTGGACTT GATCCAAGAG 
GAAGACCCTT CCCCTGAGGA ACCAACCTCT TGTGCTGAGA GCTTTCGGGT TGACCTGGAC 
AAGTCTGTGG CCCAGCTGGC AGGGAGCCGG CGGAGAGCGG ACTCAGACCG CATCCAGCCC 
TCCGCAGACC GGGCAAGCAG TCTCTCCCGA CCTTGGGAAA AAACAGACAA AGGGGCCACC 
TACACCCCCC AGGCACCCAA GAAGTTGACG CCCACAGAGA AAGGCCGCTG CGCCTCCCTG 
GAGGAGATCC TATCTCAGCG GGATGCTGCC TCTGCCCGCA CCCTCCAGCT GCGGGCTGAG 
GAACCCCCAA CCCCTGCCCT CCCCAACCCG GGGCAGCTGT CCCGGATCCA GGACCTGGTA 
GCAAGGAAAC TGGAGGAGAC TCAGGAGCTT CTGGCAGAGG TTCAGGGACT GGGAGATGGG 
AAGCGAAAGG CCAAGGACCC CCCTCGGTCT CCGCCGGATT CTGAGTCAGA GCAGCTGCTG 
CTGGAGACGG AACGGCTGCT GGGAGAGGCA TCATCGAATT GGAGCCAGGC AAAGAGGGTG 
CTGCAGGAGG TCAGGGAGCT GAGAGACCTG TACAGACAGA TGGACCTGCA GACCCCGGAC 
TCCCACCTCA GACAGACCAC CCCGCACAGT CAGTACCGGA AGAGCCTGAT GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PLEKHO1 ( NM_001304722.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001291651.1 Homo sapiens pleckstrin homology domain containing O1 (PLEKHO1), transcript variant 2, mRNA.

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CloneID	OHu67740
Clone ID Related Accession (Same CDS sequence)	NM_001304723.1 , NM_001304722.1 , XM_017001420.1 , XM_017001420.2
Accession Version	NM_001304722.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 714bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-07
Organism	Homo sapiens(human)
Product	pleckstrin homology domain-containing family O member 1 isoform b
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BX353413.2, BX376480.2, DA604331.1, BX394578.2, AF192912.1 and AK025937.1. Transcript Variant: This variant (2) uses an alternate first exon in place of that of variant 1, which causes translation initiation at a downstream AUG. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2 and 3 both encode the same isoform (b). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163657.121099.1, SRR1163658.520808.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCTGTGG CTTCCACCTC TACCTCGGAT GGGATGCTGA CCTTGGACTT GATCCAAGAG 
GAAGACCCTT CCCCTGAGGA ACCAACCTCT TGTGCTGAGA GCTTTCGGGT TGACCTGGAC 
AAGTCTGTGG CCCAGCTGGC AGGGAGCCGG CGGAGAGCGG ACTCAGACCG CATCCAGCCC 
TCCGCAGACC GGGCAAGCAG TCTCTCCCGA CCTTGGGAAA AAACAGACAA AGGGGCCACC 
TACACCCCCC AGGCACCCAA GAAGTTGACG CCCACAGAGA AAGGCCGCTG CGCCTCCCTG 
GAGGAGATCC TATCTCAGCG GGATGCTGCC TCTGCCCGCA CCCTCCAGCT GCGGGCTGAG 
GAACCCCCAA CCCCTGCCCT CCCCAACCCG GGGCAGCTGT CCCGGATCCA GGACCTGGTA 
GCAAGGAAAC TGGAGGAGAC TCAGGAGCTT CTGGCAGAGG TTCAGGGACT GGGAGATGGG 
AAGCGAAAGG CCAAGGACCC CCCTCGGTCT CCGCCGGATT CTGAGTCAGA GCAGCTGCTG 
CTGGAGACGG AACGGCTGCT GGGAGAGGCA TCATCGAATT GGAGCCAGGC AAAGAGGGTG 
CTGCAGGAGG TCAGGGAGCT GAGAGACCTG TACAGACAGA TGGACCTGCA GACCCCGGAC 
TCCCACCTCA GACAGACCAC CCCGCACAGT CAGTACCGGA AGAGCCTGAT GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001291651.1
CDS	840..1553
Translation	MAVASTSTSDGMLTLDLIQEEDPSPEEPTSCAESFRVDLDKSVAQLAGSRRRADSDRIQPSADRASSLSRPWEKTDKGATYTPQAPKKLTPTEKGRCASLEEILSQRDAASARTLQLRAEEPPTPALPNPGQLSRIQDLVARKLEETQELLAEVQGLGDGKRKAKDPPRSPPDSESEQLLLETERLLGEASSNWSQAKRVLQEVRELRDLYRQMDLQTPDSHLRQTTPHSQYRKSLM

Target ORF information:

RefSeq Version	NM_001304722.1
Organism	Homo sapiens(human)
Definition	Homo sapiens pleckstrin homology domain containing O1 (PLEKHO1), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001304722.1

ORF Insert Sequence:

ATGGCTGTGG CTTCCACCTC TACCTCGGAT GGGATGCTGA CCTTGGACTT GATCCAAGAG 
GAAGACCCTT CCCCTGAGGA ACCAACCTCT TGTGCTGAGA GCTTTCGGGT TGACCTGGAC 
AAGTCTGTGG CCCAGCTGGC AGGGAGCCGG CGGAGAGCGG ACTCAGACCG CATCCAGCCC 
TCCGCAGACC GGGCAAGCAG TCTCTCCCGA CCTTGGGAAA AAACAGACAA AGGGGCCACC 
TACACCCCCC AGGCACCCAA GAAGTTGACG CCCACAGAGA AAGGCCGCTG CGCCTCCCTG 
GAGGAGATCC TATCTCAGCG GGATGCTGCC TCTGCCCGCA CCCTCCAGCT GCGGGCTGAG 
GAACCCCCAA CCCCTGCCCT CCCCAACCCG GGGCAGCTGT CCCGGATCCA GGACCTGGTA 
GCAAGGAAAC TGGAGGAGAC TCAGGAGCTT CTGGCAGAGG TTCAGGGACT GGGAGATGGG 
AAGCGAAAGG CCAAGGACCC CCCTCGGTCT CCGCCGGATT CTGAGTCAGA GCAGCTGCTG 
CTGGAGACGG AACGGCTGCT GGGAGAGGCA TCATCGAATT GGAGCCAGGC AAAGAGGGTG 
CTGCAGGAGG TCAGGGAGCT GAGAGACCTG TACAGACAGA TGGACCTGCA GACCCCGGAC 
TCCCACCTCA GACAGACCAC CCCGCACAGT CAGTACCGGA AGAGCCTGAT GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PLEKHO1 ( NM_001304724.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001291653.1 Homo sapiens pleckstrin homology domain containing O1 (PLEKHO1), transcript variant 4, mRNA.

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CloneID	OHu67741
Clone ID Related Accession (Same CDS sequence)	NM_001304724.1
Accession Version	NM_001304724.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 681bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-07
Organism	Homo sapiens(human)
Product	pleckstrin homology domain-containing family O member 1 isoform c
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BX353413.2, BX376480.2, BC023533.2 and AK025937.1. Transcript Variant: This variant (4) lacks an alternate 3' exon and uses an alternate first exon in place of that of variant 1, which causes translation initiation at a downstream AUG. The resulting isoform (c) is shorter at the N-terminus compared to isoform a. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC023533.2 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCTGACCT TGGACTTGAT CCAAGAGGAA GACCCTTCCC CTGAGGAACC AACCTCTTGT 
GCTGAGAGCT TTCGGGTTGA CCTGGACAAG TCTGTGGCCC AGCTGGCAGG GAGCCGGCGG 
AGAGCGGACT CAGACCGCAT CCAGCCCTCC GCAGACCGGG CAAGCAGTCT CTCCCGACCT 
TGGGAAAAAA CAGACAAAGG GGCCACCTAC ACCCCCCAGG CACCCAAGAA GTTGACGCCC 
ACAGAGAAAG GCCGCTGCGC CTCCCTGGAG GAGATCCTAT CTCAGCGGGA TGCTGCCTCT 
GCCCGCACCC TCCAGCTGCG GGCTGAGGAA CCCCCAACCC CTGCCCTCCC CAACCCGGGG 
CAGCTGTCCC GGATCCAGGA CCTGGTAGCA AGGAAACTGG AGGAGACTCA GGAGCTTCTG 
GCAGAGGTTC AGGGACTGGG AGATGGGAAG CGAAAGGCCA AGGACCCCCC TCGGTCTCCG 
CCGGATTCTG AGTCAGAGCA GCTGCTGCTG GAGACGGAAC GGCTGCTGGG AGAGGCATCA 
TCGAATTGGA GCCAGGCAAA GAGGGTGCTG CAGGAGGTCA GGGAGCTGAG AGACCTGTAC 
AGACAGATGG ACCTGCAGAC CCCGGACTCC CACCTCAGAC AGACCACCCC GCACAGTCAG 
TACCGGAAGA GCCTGATGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001291653.1
CDS	771..1451
Translation	MLTLDLIQEEDPSPEEPTSCAESFRVDLDKSVAQLAGSRRRADSDRIQPSADRASSLSRPWEKTDKGATYTPQAPKKLTPTEKGRCASLEEILSQRDAASARTLQLRAEEPPTPALPNPGQLSRIQDLVARKLEETQELLAEVQGLGDGKRKAKDPPRSPPDSESEQLLLETERLLGEASSNWSQAKRVLQEVRELRDLYRQMDLQTPDSHLRQTTPHSQYRKSLM

Target ORF information:

RefSeq Version	NM_001304724.1
Organism	Homo sapiens(human)
Definition	Homo sapiens pleckstrin homology domain containing O1 (PLEKHO1), transcript variant 4, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001304724.1

ORF Insert Sequence:

ATGCTGACCT TGGACTTGAT CCAAGAGGAA GACCCTTCCC CTGAGGAACC AACCTCTTGT 
GCTGAGAGCT TTCGGGTTGA CCTGGACAAG TCTGTGGCCC AGCTGGCAGG GAGCCGGCGG 
AGAGCGGACT CAGACCGCAT CCAGCCCTCC GCAGACCGGG CAAGCAGTCT CTCCCGACCT 
TGGGAAAAAA CAGACAAAGG GGCCACCTAC ACCCCCCAGG CACCCAAGAA GTTGACGCCC 
ACAGAGAAAG GCCGCTGCGC CTCCCTGGAG GAGATCCTAT CTCAGCGGGA TGCTGCCTCT 
GCCCGCACCC TCCAGCTGCG GGCTGAGGAA CCCCCAACCC CTGCCCTCCC CAACCCGGGG 
CAGCTGTCCC GGATCCAGGA CCTGGTAGCA AGGAAACTGG AGGAGACTCA GGAGCTTCTG 
GCAGAGGTTC AGGGACTGGG AGATGGGAAG CGAAAGGCCA AGGACCCCCC TCGGTCTCCG 
CCGGATTCTG AGTCAGAGCA GCTGCTGCTG GAGACGGAAC GGCTGCTGGG AGAGGCATCA 
TCGAATTGGA GCCAGGCAAA GAGGGTGCTG CAGGAGGTCA GGGAGCTGAG AGACCTGTAC 
AGACAGATGG ACCTGCAGAC CCCGGACTCC CACCTCAGAC AGACCACCCC GCACAGTCAG 
TACCGGAAGA GCCTGATGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PLEKHO1 ( XM_017001420.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016856909.1 Homo sapiens pleckstrin homology domain containing O1 (PLEKHO1), transcript variant X1, mRNA.

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CloneID	OHu67740
Clone ID Related Accession (Same CDS sequence)	NM_001304723.1 , NM_001304722.1 , XM_017001420.1 , XM_017001420.2
Accession Version	XM_017001420.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 714bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	pleckstrin homology domain-containing family O member 1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000001.11) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCTGTGG CTTCCACCTC TACCTCGGAT GGGATGCTGA CCTTGGACTT GATCCAAGAG 
GAAGACCCTT CCCCTGAGGA ACCAACCTCT TGTGCTGAGA GCTTTCGGGT TGACCTGGAC 
AAGTCTGTGG CCCAGCTGGC AGGGAGCCGG CGGAGAGCGG ACTCAGACCG CATCCAGCCC 
TCCGCAGACC GGGCAAGCAG TCTCTCCCGA CCTTGGGAAA AAACAGACAA AGGGGCCACC 
TACACCCCCC AGGCACCCAA GAAGTTGACG CCCACAGAGA AAGGCCGCTG CGCCTCCCTG 
GAGGAGATCC TATCTCAGCG GGATGCTGCC TCTGCCCGCA CCCTCCAGCT GCGGGCTGAG 
GAACCCCCAA CCCCTGCCCT CCCCAACCCG GGGCAGCTGT CCCGGATCCA GGACCTGGTA 
GCAAGGAAAC TGGAGGAGAC TCAGGAGCTT CTGGCAGAGG TTCAGGGACT GGGAGATGGG 
AAGCGAAAGG CCAAGGACCC CCCTCGGTCT CCGCCGGATT CTGAGTCAGA GCAGCTGCTG 
CTGGAGACGG AACGGCTGCT GGGAGAGGCA TCATCGAATT GGAGCCAGGC AAAGAGGGTG 
CTGCAGGAGG TCAGGGAGCT GAGAGACCTG TACAGACAGA TGGACCTGCA GACCCCGGAC 
TCCCACCTCA GACAGACCAC CCCGCACAGT CAGTACCGGA AGAGCCTGAT GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016856909.1
CDS	850..1563
Translation	MAVASTSTSDGMLTLDLIQEEDPSPEEPTSCAESFRVDLDKSVAQLAGSRRRADSDRIQPSADRASSLSRPWEKTDKGATYTPQAPKKLTPTEKGRCASLEEILSQRDAASARTLQLRAEEPPTPALPNPGQLSRIQDLVARKLEETQELLAEVQGLGDGKRKAKDPPRSPPDSESEQLLLETERLLGEASSNWSQAKRVLQEVRELRDLYRQMDLQTPDSHLRQTTPHSQYRKSLM

Target ORF information:

RefSeq Version	XM_017001420.1
Organism	Homo sapiens(human)
Definition	Homo sapiens pleckstrin homology domain containing O1 (PLEKHO1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017001420.1

ORF Insert Sequence:

ATGGCTGTGG CTTCCACCTC TACCTCGGAT GGGATGCTGA CCTTGGACTT GATCCAAGAG 
GAAGACCCTT CCCCTGAGGA ACCAACCTCT TGTGCTGAGA GCTTTCGGGT TGACCTGGAC 
AAGTCTGTGG CCCAGCTGGC AGGGAGCCGG CGGAGAGCGG ACTCAGACCG CATCCAGCCC 
TCCGCAGACC GGGCAAGCAG TCTCTCCCGA CCTTGGGAAA AAACAGACAA AGGGGCCACC 
TACACCCCCC AGGCACCCAA GAAGTTGACG CCCACAGAGA AAGGCCGCTG CGCCTCCCTG 
GAGGAGATCC TATCTCAGCG GGATGCTGCC TCTGCCCGCA CCCTCCAGCT GCGGGCTGAG 
GAACCCCCAA CCCCTGCCCT CCCCAACCCG GGGCAGCTGT CCCGGATCCA GGACCTGGTA 
GCAAGGAAAC TGGAGGAGAC TCAGGAGCTT CTGGCAGAGG TTCAGGGACT GGGAGATGGG 
AAGCGAAAGG CCAAGGACCC CCCTCGGTCT CCGCCGGATT CTGAGTCAGA GCAGCTGCTG 
CTGGAGACGG AACGGCTGCT GGGAGAGGCA TCATCGAATT GGAGCCAGGC AAAGAGGGTG 
CTGCAGGAGG TCAGGGAGCT GAGAGACCTG TACAGACAGA TGGACCTGCA GACCCCGGAC 
TCCCACCTCA GACAGACCAC CCCGCACAGT CAGTACCGGA AGAGCCTGAT GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PLEKHO1 ( XM_017001420.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_016856909.1 Homo sapiens pleckstrin homology domain containing O1 (PLEKHO1), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OHu67740
Clone ID Related Accession (Same CDS sequence)	NM_001304723.1 , NM_001304722.1 , XM_017001420.1 , XM_017001420.2
Accession Version	XM_017001420.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 714bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	pleckstrin homology domain-containing family O member 1 isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000001.11) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_017001420.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCTGTGG CTTCCACCTC TACCTCGGAT GGGATGCTGA CCTTGGACTT GATCCAAGAG 
GAAGACCCTT CCCCTGAGGA ACCAACCTCT TGTGCTGAGA GCTTTCGGGT TGACCTGGAC 
AAGTCTGTGG CCCAGCTGGC AGGGAGCCGG CGGAGAGCGG ACTCAGACCG CATCCAGCCC 
TCCGCAGACC GGGCAAGCAG TCTCTCCCGA CCTTGGGAAA AAACAGACAA AGGGGCCACC 
TACACCCCCC AGGCACCCAA GAAGTTGACG CCCACAGAGA AAGGCCGCTG CGCCTCCCTG 
GAGGAGATCC TATCTCAGCG GGATGCTGCC TCTGCCCGCA CCCTCCAGCT GCGGGCTGAG 
GAACCCCCAA CCCCTGCCCT CCCCAACCCG GGGCAGCTGT CCCGGATCCA GGACCTGGTA 
GCAAGGAAAC TGGAGGAGAC TCAGGAGCTT CTGGCAGAGG TTCAGGGACT GGGAGATGGG 
AAGCGAAAGG CCAAGGACCC CCCTCGGTCT CCGCCGGATT CTGAGTCAGA GCAGCTGCTG 
CTGGAGACGG AACGGCTGCT GGGAGAGGCA TCATCGAATT GGAGCCAGGC AAAGAGGGTG 
CTGCAGGAGG TCAGGGAGCT GAGAGACCTG TACAGACAGA TGGACCTGCA GACCCCGGAC 
TCCCACCTCA GACAGACCAC CCCGCACAGT CAGTACCGGA AGAGCCTGAT GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016856909.1
CDS	883..1596
Translation	MAVASTSTSDGMLTLDLIQEEDPSPEEPTSCAESFRVDLDKSVAQLAGSRRRADSDRIQPSADRASSLSRPWEKTDKGATYTPQAPKKLTPTEKGRCASLEEILSQRDAASARTLQLRAEEPPTPALPNPGQLSRIQDLVARKLEETQELLAEVQGLGDGKRKAKDPPRSPPDSESEQLLLETERLLGEASSNWSQAKRVLQEVRELRDLYRQMDLQTPDSHLRQTTPHSQYRKSLM

Target ORF information:

RefSeq Version	XM_017001420.2
Organism	Homo sapiens(human)
Definition	Homo sapiens pleckstrin homology domain containing O1 (PLEKHO1), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017001420.2

ORF Insert Sequence:

ATGGCTGTGG CTTCCACCTC TACCTCGGAT GGGATGCTGA CCTTGGACTT GATCCAAGAG 
GAAGACCCTT CCCCTGAGGA ACCAACCTCT TGTGCTGAGA GCTTTCGGGT TGACCTGGAC 
AAGTCTGTGG CCCAGCTGGC AGGGAGCCGG CGGAGAGCGG ACTCAGACCG CATCCAGCCC 
TCCGCAGACC GGGCAAGCAG TCTCTCCCGA CCTTGGGAAA AAACAGACAA AGGGGCCACC 
TACACCCCCC AGGCACCCAA GAAGTTGACG CCCACAGAGA AAGGCCGCTG CGCCTCCCTG 
GAGGAGATCC TATCTCAGCG GGATGCTGCC TCTGCCCGCA CCCTCCAGCT GCGGGCTGAG 
GAACCCCCAA CCCCTGCCCT CCCCAACCCG GGGCAGCTGT CCCGGATCCA GGACCTGGTA 
GCAAGGAAAC TGGAGGAGAC TCAGGAGCTT CTGGCAGAGG TTCAGGGACT GGGAGATGGG 
AAGCGAAAGG CCAAGGACCC CCCTCGGTCT CCGCCGGATT CTGAGTCAGA GCAGCTGCTG 
CTGGAGACGG AACGGCTGCT GGGAGAGGCA TCATCGAATT GGAGCCAGGC AAAGAGGGTG 
CTGCAGGAGG TCAGGGAGCT GAGAGACCTG TACAGACAGA TGGACCTGCA GACCCCGGAC 
TCCCACCTCA GACAGACCAC CCCGCACAGT CAGTACCGGA AGAGCCTGAT GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PLEKHO1 ( XM_024447478.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_024303246.1 Homo sapiens pleckstrin homology domain containing O1 (PLEKHO1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu105060
Clone ID Related Accession (Same CDS sequence)	XM_024447478.1
Accession Version	XM_024447478.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 831bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	pleckstrin homology domain-containing family O member 1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000001.11) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGATTCACA GTACATCTCT TCAGGTCACC GTTGAGGAGG ACAGCTATCT TGCCCATCCC 
ACTCGAGACA GGGCAAAAAT CCAGCACTCC CGCCGCCCCC CAACAAGGGG ACACCTAATG 
GCTGTGGCTT CCACCTCTAC CTCGGATGGG ATGCTGACCT TGGACTTGAT CCAAGAGGAA 
GACCCTTCCC CTGAGGAACC AACCTCTTGT GCTGAGAGCT TTCGGGTTGA CCTGGACAAG 
TCTGTGGCCC AGCTGGCAGG GAGCCGGCGG AGAGCGGACT CAGACCGCAT CCAGCCCTCC 
GCAGACCGGG CAAGCAGTCT CTCCCGACCT TGGGAAAAAA CAGACAAAGG GGCCACCTAC 
ACCCCCCAGG CACCCAAGAA GTTGACGCCC ACAGAGAAAG GCCGCTGCGC CTCCCTGGAG 
GAGATCCTAT CTCAGCGGGA TGCTGCCTCT GCCCGCACCC TCCAGCTGCG GGCTGAGGAA 
CCCCCAACCC CTGCCCTCCC CAACCCGGGG CAGCTGTCCC GGATCCAGGA CCTGGTAGCA 
AGGAAACTGG AGGAGACTCA GGAGCTTCTG GCAGAGGTTC AGGGACTGGG AGATGGGAAG 
CGAAAGGCCA AGGACCCCCC TCGGTCTCCG CCGGATTCTG AGTCAGAGCA GCTGCTGCTG 
GAGACGGAAC GGCTGCTGGG AGAGGCATCA TCGAATTGGA GCCAGGCAAA GAGGGTGCTG 
CAGGAGGTCA GGGAGCTGAG AGACCTGTAC AGACAGATGG ACCTGCAGAC CCCGGACTCC 
CACCTCAGAC AGACCACCCC GCACAGTCAG TACCGGAAGA GCCTGATGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_024303246.1
CDS	961..1791
Translation	MIHSTSLQVTVEEDSYLAHPTRDRAKIQHSRRPPTRGHLMAVASTSTSDGMLTLDLIQEEDPSPEEPTSCAESFRVDLDKSVAQLAGSRRRADSDRIQPSADRASSLSRPWEKTDKGATYTPQAPKKLTPTEKGRCASLEEILSQRDAASARTLQLRAEEPPTPALPNPGQLSRIQDLVARKLEETQELLAEVQGLGDGKRKAKDPPRSPPDSESEQLLLETERLLGEASSNWSQAKRVLQEVRELRDLYRQMDLQTPDSHLRQTTPHSQYRKSLM

Target ORF information:

RefSeq Version	XM_024447478.1
Organism	Homo sapiens(human)
Definition	Homo sapiens pleckstrin homology domain containing O1 (PLEKHO1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_024447478.1

ORF Insert Sequence:

ATGATTCACA GTACATCTCT TCAGGTCACC GTTGAGGAGG ACAGCTATCT TGCCCATCCC 
ACTCGAGACA GGGCAAAAAT CCAGCACTCC CGCCGCCCCC CAACAAGGGG ACACCTAATG 
GCTGTGGCTT CCACCTCTAC CTCGGATGGG ATGCTGACCT TGGACTTGAT CCAAGAGGAA 
GACCCTTCCC CTGAGGAACC AACCTCTTGT GCTGAGAGCT TTCGGGTTGA CCTGGACAAG 
TCTGTGGCCC AGCTGGCAGG GAGCCGGCGG AGAGCGGACT CAGACCGCAT CCAGCCCTCC 
GCAGACCGGG CAAGCAGTCT CTCCCGACCT TGGGAAAAAA CAGACAAAGG GGCCACCTAC 
ACCCCCCAGG CACCCAAGAA GTTGACGCCC ACAGAGAAAG GCCGCTGCGC CTCCCTGGAG 
GAGATCCTAT CTCAGCGGGA TGCTGCCTCT GCCCGCACCC TCCAGCTGCG GGCTGAGGAA 
CCCCCAACCC CTGCCCTCCC CAACCCGGGG CAGCTGTCCC GGATCCAGGA CCTGGTAGCA 
AGGAAACTGG AGGAGACTCA GGAGCTTCTG GCAGAGGTTC AGGGACTGGG AGATGGGAAG 
CGAAAGGCCA AGGACCCCCC TCGGTCTCCG CCGGATTCTG AGTCAGAGCA GCTGCTGCTG 
GAGACGGAAC GGCTGCTGGG AGAGGCATCA TCGAATTGGA GCCAGGCAAA GAGGGTGCTG 
CAGGAGGTCA GGGAGCTGAG AGACCTGTAC AGACAGATGG ACCTGCAGAC CCCGGACTCC 
CACCTCAGAC AGACCACCCC GCACAGTCAG TACCGGAAGA GCCTGATGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Association of CKIP-1 P21A polymorphism with risk of chronic heart failure in a Chinese population.
Oncotarget8(22)36545-36552(2017 May)
Li MP,Zhang YJ,Hu XL,Zhou JP,Yang YL,Peng LM,Qi H,Yang TL,Chen XP

A novel role of CKIP-1 in promoting megakaryocytic differentiation.
Oncotarget8(18)30138-30150(2017 May)
Fan J,Wang Y,Shen Y,Liu Q,Gao R,Qiu Y,Wang C,Zhang L

Casein Kinase 2 Interacting Protein-1 regulates M1 and M2 inflammatory macrophage polarization.
Cellular signalling33107-121(2017 May)
Chen Y,Liu W,Wang Y,Zhang L,Wei J,Zhang X,He F,Zhang L

Increased PLEKHO1 within osteoblasts suppresses Smad-dependent BMP signaling to inhibit bone formation during aging.
Aging cell16(2)360-376(2017 Apr)
Liu J,Liang C,Guo B,Wu X,Li D,Zhang Z,Zheng K,Dang L,He X,Lu C,Peng S,Pan X,Zhang BT,Lu A,Zhang G

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PLEKHO1 cDNA ORF clone, Homo sapiens(human)

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gRNAs

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