CYB5R4 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	CYB5R4
Entrez Gene ID	51167
Full Name	cytochrome b5 reductase 4
Synonyms	NCB5OR,cb5/cb5R,dJ676J13.1
General protein information	Preferred Names cytochrome b5 reductase 4 Names cytochrome b5 reductase 4 N-terminal cytochrome b5 and cytochrome b5 oxidoreductase domain-containing protein NADPH cytochrome B5 oxidoreductase cytochrome b-type NAD(P)H oxidoreductase flavohemoprotein b5+b5R flavohemoprotein b5/b5R
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 6 Map Location: 6q14.2
Summary	NCB5OR is a flavohemoprotein that contains functional domains found in both cytochrome b5 (CYB5A; MIM 613218) and CYB5 reductase (CYB5R3; MIM 613213) (Zhu et al., 1999 [PubMed 10611283]).[supplied by OMIM, Jan 2010].
Disorder MIM:	608343

mRNA and Protein(s)

mRNA	Protein	Name
NM_016230.3	NP_057314.2	cytochrome b5 reductase 4
NM_016230.4	NP_057314.2	cytochrome b5 reductase 4

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	CYB5R4	XP_518614.3
Bos taurus (cattle)	CYB5R4	NP_001033248.1
Gallus gallus (chicken)	CYB5R4	XP_001233871.1
	CYB5R4	XP_001085835.1
Canis lupus familiaris (dog)	CYB5R4	XP_532219.3
Mus musculus (house mouse)	Cyb5r4	NP_077157.2
Rattus norvegicus (Norway rat)	Cyb5r4	NP_596918.3
Danio rerio (zebrafish)	cyb5r4	NP_001018496.1
Xenopus tropicalis (tropical clawed frog)	cyb5r4	NP_001016756.1
Drosophila melanogaster (fruit fly)	CG11257	NP_611419.1
Caenorhabditis elegans (roundworm)	CELE_Y52B11A.3	NP_001021784.2
Homo sapiens (human)	CYB5R4	NP_057314.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP011314	XP_309336.4

Gene Ontology
Bibliography

Related articles in PubMed

Cytosolic localization of NADH cytochrome b? oxidoreductase (Ncb5or).
Z?mb? V, T?th M, Schlachter K, Szel?nyi P, Sarnyai F, Lotz G, Csala M, Kereszturi ?
FEBS letters590(5)661-71(2016 Mar)

Natural mutations lead to enhanced proteasomal degradation of human Ncb5or, a novel flavoheme reductase.
K?lm?n FS, Liz?k B, Nagy SK, M?sz?ros T, Z?mb? V, Mandl J, Csala M, Kereszturi E
Biochimie95(7)1403-10(2013 Jul)

Methemoglobin reductase deficiency: novel mutation is associated with a disease phenotype of intermediate severity.
Percy MJ, Barnes C, Crighton G, Leventer RJ, Wynn R, Lappin TR
Journal of pediatric hematology/oncology34(6)457-60(2012 Aug)

Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S,
Diabetes care33(10)2250-3(2010 Oct)

Study of the individual cytochrome b5 and cytochrome b5 reductase domains of Ncb5or reveals a unique heme pocket and a possible role of the CS domain.
Deng B, Parthasarathy S, Wang W, Gibney BR, Battaile KP, Lovell S, Benson DR, Zhu H
The Journal of biological chemistry285(39)30181-91(2010 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Cytosolic localization of NADH cytochrome b oxidoreductase
Title: Cytosolic localization of NADH cytochrome b? oxidoreductase (Ncb5or).

data provide first evidence for natural mutations in NCB5OR gene resulting in decreased protein levels and hence having potential implications in human pathology.
Title: Natural mutations lead to enhanced proteasomal degradation of human Ncb5or, a novel flavoheme reductase.

Mutation in cytochrome b5 reductase is associated with developmental delay and severe neurological problems.
Title: Methemoglobin reductase deficiency: novel mutation is associated with a disease phenotype of intermediate severity.

Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.

Study of the individual cytochrome b5 and cytochrome b5 reductase domains of Ncb5or reveals a unique heme pocket and a possible role of the CS domain.
Title: Study of the individual cytochrome b5 and cytochrome b5 reductase domains of Ncb5or reveals a unique heme pocket and a possible role of the CS domain.

The following CYB5R4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CYB5R4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu13116	NM_016230.4 Latest version!	Homo sapiens cytochrome b5 reductase 4 (CYB5R4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
View Old Accession Versions >>
OHu13116	NM_016230.3	Homo sapiens cytochrome b5 reductase 4 (CYB5R4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CYB5R4 ( NM_016230.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_057314.2 Homo sapiens cytochrome b5 reductase 4 (CYB5R4), mRNA.

Price & Availability↑

CloneID	OHu13116
Clone ID Related Accession (Same CDS sequence)	NM_016230.3 , NM_016230.4
Accession Version	NM_016230.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1566bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	cytochrome b5 reductase 4
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DA274558.1, BC025380.1 and BC029339.1. On Jan 14, 2006 this sequence version replaced NM_016230.2. ##Evidence-Data-START## Transcript exon combination :: SRR1163657.397804.1, SRR1660807.68455.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCTGAACG TCCCTTCCCA GTCTTTCCCG GCCCCCAGGT CGCAGCAGCG TGTCGCCTCC 
GGGGGGCGTA GCAAGGTACC TTTAAAACAG GGCAGAAGCC TTATGGATTG GATTCGACTG 
ACCAAAAGTG GAAAGGATCT AACGGGATTA AAAGGCAGGT TAATTGAAGT AACTGAAGAA 
GAACTTAAGA AACACAACAA AAAAGATGAT TGTTGGATAT GCATAAGAGG TTTCGTTTAT 
AATGTCAGCC CTTATATGGA GTATCATCCT GGTGGAGAAG ATGAACTAAT GAGAGCAGCA 
GGATCAGATG GTACTGAACT TTTTGATCAG GTTCATCGTT GGGTCAATTA TGAATCCATG 
CTGAAAGAAT GCCTGGTTGG CAGAATGGCC ATTAAACCTG CTGTTCTGAA AGACTATCGT 
GAGGAGGAAA AGAAAGTCTT AAATGGCATG CTTCCCAAGA GCCAAGTGAC AGATACACTT 
GCCAAAGAAG GTCCTAGTTA TCCAAGCTAT GATTGGTTCC AAACAGACTC TTTAGTCACC 
ATTGCCATAT ATACTAAACA GAAGGATATC AATTTAGACT CAATAATAGT TGATCATCAG 
AATGATTCCT TTAGAGCAGA AACAATTATT AAGGATTGTT TATATCTTAT ACATATTGGG 
CTAAGCCATG AGGTTCAGGA AGATTTTTCT GTGCGGGTTG TTGAGAGTGT GGGAAAAATA 
GAGATTGTTC TACAAAAAAA AGAGAATACT TCTTGGGACT TTCTTGGCCA TCCCCTGAAG 
AATCATAATT CACTTATTCC AAGGAAAGAT ACAGGTTTGT ACTACAGAAA GTGCCAGTTA 
ATTTCCAAGG AAGATGTTAC TCATGATACG AGGCTTTTCT GTTTGATGCT GCCACCAAGC 
ACTCATCTTC AAGTGCCCAT TGGGCAACAT GTTTACCTCA AGCTACCTAT TACAGGTACA 
GAAATAGTAA AGCCATATAC ACCTGTATCT GGTTCCTTAC TCTCAGAGTT CAAGGAACCA 
GTTCTTCCCA ACAATAAATA CATCTACTTT TTGATAAAAA TCTATCCCAC TGGACTCTTC 
ACACCAGAGC TTGATCGTCT TCAGATTGGA GATTTTGTTT CTGTAAGCAG TCCTGAGGGC 
AATTTTAAAA TATCCAAGTT CCAAGAATTA GAAGATCTCT TTTTGTTGGC AGCTGGAACA 
GGCTTCACAC CAATGGTTAA AATACTGAAT TATGCTTTGA CTGATATACC CAGTCTCAGG 
AAAGTGAAGC TGATGTTCTT CAATAAAACA GAAGATGATA TAATTTGGAG AAGCCAATTG 
GAGAAATTAG CATTTAAAGA TAAAAGACTG GATGTTGAAT TTGTTCTCTC AGCACCTATT 
TCTGAATGGA ATGGCAAACA GGGACATATT TCACCAGCTC TTCTTTCTGA ATTTTTGAAA 
AGAAATTTGG ACAAATCCAA AGTTCTCGTC TGCATTTGTG GACCAGTGCC ATTTACAGAA 
CAAGGAGTAA GGTTGCTGCA TGATCTCAAC TTTTCCAAAA ATGAGATCCA TAGTTTTACA 
GCATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_057314.2
CDS	133..1698
Translation	MLNVPSQSFPAPRSQQRVASGGRSKVPLKQGRSLMDWIRLTKSGKDLTGLKGRLIEVTEEELKKHNKKDDCWICIRGFVYNVSPYMEYHPGGEDELMRAAGSDGTELFDQVHRWVNYESMLKECLVGRMAIKPAVLKDYREEEKKVLNGMLPKSQVTDTLAKEGPSYPSYDWFQTDSLVTIAIYTKQKDINLDSIIVDHQNDSFRAETIIKDCLYLIHIGLSHEVQEDFSVRVVESVGKIEIVLQKKENTSWDFLGHPLKNHNSLIPRKDTGLYYRKCQLISKEDVTHDTRLFCLMLPPSTHLQVPIGQHVYLKLPITGTEIVKPYTPVSGSLLSEFKEPVLPNNKYIYFLIKIYPTGLFTPELDRLQIGDFVSVSSPEGNFKISKFQELEDLFLLAAGTGFTPMVKILNYALTDIPSLRKVKLMFFNKTEDDIIWRSQLEKLAFKDKRLDVEFVLSAPISEWNGKQGHISPALLSEFLKRNLDKSKVLVCICGPVPFTEQGVRLLHDLNFSKNEIHSFTA

Target ORF information:

RefSeq Version	NM_016230.3
Organism	Homo sapiens(human)
Definition	Homo sapiens cytochrome b5 reductase 4 (CYB5R4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_016230.3

ORF Insert Sequence:

ATGCTGAACG TCCCTTCCCA GTCTTTCCCG GCCCCCAGGT CGCAGCAGCG TGTCGCCTCC 
GGGGGGCGTA GCAAGGTACC TTTAAAACAG GGCAGAAGCC TTATGGATTG GATTCGACTG 
ACCAAAAGTG GAAAGGATCT AACGGGATTA AAAGGCAGGT TAATTGAAGT AACTGAAGAA 
GAACTTAAGA AACACAACAA AAAAGATGAT TGTTGGATAT GCATAAGAGG TTTCGTTTAT 
AATGTCAGCC CTTATATGGA GTATCATCCT GGTGGAGAAG ATGAACTAAT GAGAGCAGCA 
GGATCAGATG GTACTGAACT TTTTGATCAG GTTCATCGTT GGGTCAATTA TGAATCCATG 
CTGAAAGAAT GCCTGGTTGG CAGAATGGCC ATTAAACCTG CTGTTCTGAA AGACTATCGT 
GAGGAGGAAA AGAAAGTCTT AAATGGCATG CTTCCCAAGA GCCAAGTGAC AGATACACTT 
GCCAAAGAAG GTCCTAGTTA TCCAAGCTAT GATTGGTTCC AAACAGACTC TTTAGTCACC 
ATTGCCATAT ATACTAAACA GAAGGATATC AATTTAGACT CAATAATAGT TGATCATCAG 
AATGATTCCT TTAGAGCAGA AACAATTATT AAGGATTGTT TATATCTTAT ACATATTGGG 
CTAAGCCATG AGGTTCAGGA AGATTTTTCT GTGCGGGTTG TTGAGAGTGT GGGAAAAATA 
GAGATTGTTC TACAAAAAAA AGAGAATACT TCTTGGGACT TTCTTGGCCA TCCCCTGAAG 
AATCATAATT CACTTATTCC AAGGAAAGAT ACAGGTTTGT ACTACAGAAA GTGCCAGTTA 
ATTTCCAAGG AAGATGTTAC TCATGATACG AGGCTTTTCT GTTTGATGCT GCCACCAAGC 
ACTCATCTTC AAGTGCCCAT TGGGCAACAT GTTTACCTCA AGCTACCTAT TACAGGTACA 
GAAATAGTAA AGCCATATAC ACCTGTATCT GGTTCCTTAC TCTCAGAGTT CAAGGAACCA 
GTTCTTCCCA ACAATAAATA CATCTACTTT TTGATAAAAA TCTATCCCAC TGGACTCTTC 
ACACCAGAGC TTGATCGTCT TCAGATTGGA GATTTTGTTT CTGTAAGCAG TCCTGAGGGC 
AATTTTAAAA TATCCAAGTT CCAAGAATTA GAAGATCTCT TTTTGTTGGC AGCTGGAACA 
GGCTTCACAC CAATGGTTAA AATACTGAAT TATGCTTTGA CTGATATACC CAGTCTCAGG 
AAAGTGAAGC TGATGTTCTT CAATAAAACA GAAGATGATA TAATTTGGAG AAGCCAATTG 
GAGAAATTAG CATTTAAAGA TAAAAGACTG GATGTTGAAT TTGTTCTCTC AGCACCTATT 
TCTGAATGGA ATGGCAAACA GGGACATATT TCACCAGCTC TTCTTTCTGA ATTTTTGAAA 
AGAAATTTGG ACAAATCCAA AGTTCTCGTC TGCATTTGTG GACCAGTGCC ATTTACAGAA 
CAAGGAGTAA GGTTGCTGCA TGATCTCAAC TTTTCCAAAA ATGAGATCCA TAGTTTTACA 
GCATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CYB5R4 ( NM_016230.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_057314.2 Homo sapiens cytochrome b5 reductase 4 (CYB5R4), mRNA.

Price & Availability↑

CloneID	OHu13116
Clone ID Related Accession (Same CDS sequence)	NM_016230.3 , NM_016230.4
Accession Version	NM_016230.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1566bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-06-07
Organism	Homo sapiens(human)
Product	cytochrome b5 reductase 4
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DA274558.1, BC025380.1, BC029339.1 and AL034347.23. On Nov 23, 2018 this sequence version replaced NM_016230.3. ##Evidence-Data-START## Transcript exon combination :: SRR1660807.168530.1, SRR1803612.44040.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000369681.10/ ENSP00000358695.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGCTGAACG TCCCTTCCCA GTCTTTCCCG GCCCCCAGGT CGCAGCAGCG TGTCGCCTCC 
GGGGGGCGTA GCAAGGTACC TTTAAAACAG GGCAGAAGCC TTATGGATTG GATTCGACTG 
ACCAAAAGTG GAAAGGATCT AACGGGATTA AAAGGCAGGT TAATTGAAGT AACTGAAGAA 
GAACTTAAGA AACACAACAA AAAAGATGAT TGTTGGATAT GCATAAGAGG TTTCGTTTAT 
AATGTCAGCC CTTATATGGA GTATCATCCT GGTGGAGAAG ATGAACTAAT GAGAGCAGCA 
GGATCAGATG GTACTGAACT TTTTGATCAG GTTCATCGTT GGGTCAATTA TGAATCCATG 
CTGAAAGAAT GCCTGGTTGG CAGAATGGCC ATTAAACCTG CTGTTCTGAA AGACTATCGT 
GAGGAGGAAA AGAAAGTCTT AAATGGCATG CTTCCCAAGA GCCAAGTGAC AGATACACTT 
GCCAAAGAAG GTCCTAGTTA TCCAAGCTAT GATTGGTTCC AAACAGACTC TTTAGTCACC 
ATTGCCATAT ATACTAAACA GAAGGATATC AATTTAGACT CAATAATAGT TGATCATCAG 
AATGATTCCT TTAGAGCAGA AACAATTATT AAGGATTGTT TATATCTTAT ACATATTGGG 
CTAAGCCATG AGGTTCAGGA AGATTTTTCT GTGCGGGTTG TTGAGAGTGT GGGAAAAATA 
GAGATTGTTC TACAAAAAAA AGAGAATACT TCTTGGGACT TTCTTGGCCA TCCCCTGAAG 
AATCATAATT CACTTATTCC AAGGAAAGAT ACAGGTTTGT ACTACAGAAA GTGCCAGTTA 
ATTTCCAAGG AAGATGTTAC TCATGATACG AGGCTTTTCT GTTTGATGCT GCCACCAAGC 
ACTCATCTTC AAGTGCCCAT TGGGCAACAT GTTTACCTCA AGCTACCTAT TACAGGTACA 
GAAATAGTAA AGCCATATAC ACCTGTATCT GGTTCCTTAC TCTCAGAGTT CAAGGAACCA 
GTTCTTCCCA ACAATAAATA CATCTACTTT TTGATAAAAA TCTATCCCAC TGGACTCTTC 
ACACCAGAGC TTGATCGTCT TCAGATTGGA GATTTTGTTT CTGTAAGCAG TCCTGAGGGC 
AATTTTAAAA TATCCAAGTT CCAAGAATTA GAAGATCTCT TTTTGTTGGC AGCTGGAACA 
GGCTTCACAC CAATGGTTAA AATACTGAAT TATGCTTTGA CTGATATACC CAGTCTCAGG 
AAAGTGAAGC TGATGTTCTT CAATAAAACA GAAGATGATA TAATTTGGAG AAGCCAATTG 
GAGAAATTAG CATTTAAAGA TAAAAGACTG GATGTTGAAT TTGTTCTCTC AGCACCTATT 
TCTGAATGGA ATGGCAAACA GGGACATATT TCACCAGCTC TTCTTTCTGA ATTTTTGAAA 
AGAAATTTGG ACAAATCCAA AGTTCTCGTC TGCATTTGTG GACCAGTGCC ATTTACAGAA 
CAAGGAGTAA GGTTGCTGCA TGATCTCAAC TTTTCCAAAA ATGAGATCCA TAGTTTTACA 
GCATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_057314.2
CDS	95..1660
Translation	MLNVPSQSFPAPRSQQRVASGGRSKVPLKQGRSLMDWIRLTKSGKDLTGLKGRLIEVTEEELKKHNKKDDCWICIRGFVYNVSPYMEYHPGGEDELMRAAGSDGTELFDQVHRWVNYESMLKECLVGRMAIKPAVLKDYREEEKKVLNGMLPKSQVTDTLAKEGPSYPSYDWFQTDSLVTIAIYTKQKDINLDSIIVDHQNDSFRAETIIKDCLYLIHIGLSHEVQEDFSVRVVESVGKIEIVLQKKENTSWDFLGHPLKNHNSLIPRKDTGLYYRKCQLISKEDVTHDTRLFCLMLPPSTHLQVPIGQHVYLKLPITGTEIVKPYTPVSGSLLSEFKEPVLPNNKYIYFLIKIYPTGLFTPELDRLQIGDFVSVSSPEGNFKISKFQELEDLFLLAAGTGFTPMVKILNYALTDIPSLRKVKLMFFNKTEDDIIWRSQLEKLAFKDKRLDVEFVLSAPISEWNGKQGHISPALLSEFLKRNLDKSKVLVCICGPVPFTEQGVRLLHDLNFSKNEIHSFTA

Target ORF information:

RefSeq Version	NM_016230.4
Organism	Homo sapiens(human)
Definition	Homo sapiens cytochrome b5 reductase 4 (CYB5R4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_016230.4

ORF Insert Sequence:

ATGCTGAACG TCCCTTCCCA GTCTTTCCCG GCCCCCAGGT CGCAGCAGCG TGTCGCCTCC 
GGGGGGCGTA GCAAGGTACC TTTAAAACAG GGCAGAAGCC TTATGGATTG GATTCGACTG 
ACCAAAAGTG GAAAGGATCT AACGGGATTA AAAGGCAGGT TAATTGAAGT AACTGAAGAA 
GAACTTAAGA AACACAACAA AAAAGATGAT TGTTGGATAT GCATAAGAGG TTTCGTTTAT 
AATGTCAGCC CTTATATGGA GTATCATCCT GGTGGAGAAG ATGAACTAAT GAGAGCAGCA 
GGATCAGATG GTACTGAACT TTTTGATCAG GTTCATCGTT GGGTCAATTA TGAATCCATG 
CTGAAAGAAT GCCTGGTTGG CAGAATGGCC ATTAAACCTG CTGTTCTGAA AGACTATCGT 
GAGGAGGAAA AGAAAGTCTT AAATGGCATG CTTCCCAAGA GCCAAGTGAC AGATACACTT 
GCCAAAGAAG GTCCTAGTTA TCCAAGCTAT GATTGGTTCC AAACAGACTC TTTAGTCACC 
ATTGCCATAT ATACTAAACA GAAGGATATC AATTTAGACT CAATAATAGT TGATCATCAG 
AATGATTCCT TTAGAGCAGA AACAATTATT AAGGATTGTT TATATCTTAT ACATATTGGG 
CTAAGCCATG AGGTTCAGGA AGATTTTTCT GTGCGGGTTG TTGAGAGTGT GGGAAAAATA 
GAGATTGTTC TACAAAAAAA AGAGAATACT TCTTGGGACT TTCTTGGCCA TCCCCTGAAG 
AATCATAATT CACTTATTCC AAGGAAAGAT ACAGGTTTGT ACTACAGAAA GTGCCAGTTA 
ATTTCCAAGG AAGATGTTAC TCATGATACG AGGCTTTTCT GTTTGATGCT GCCACCAAGC 
ACTCATCTTC AAGTGCCCAT TGGGCAACAT GTTTACCTCA AGCTACCTAT TACAGGTACA 
GAAATAGTAA AGCCATATAC ACCTGTATCT GGTTCCTTAC TCTCAGAGTT CAAGGAACCA 
GTTCTTCCCA ACAATAAATA CATCTACTTT TTGATAAAAA TCTATCCCAC TGGACTCTTC 
ACACCAGAGC TTGATCGTCT TCAGATTGGA GATTTTGTTT CTGTAAGCAG TCCTGAGGGC 
AATTTTAAAA TATCCAAGTT CCAAGAATTA GAAGATCTCT TTTTGTTGGC AGCTGGAACA 
GGCTTCACAC CAATGGTTAA AATACTGAAT TATGCTTTGA CTGATATACC CAGTCTCAGG 
AAAGTGAAGC TGATGTTCTT CAATAAAACA GAAGATGATA TAATTTGGAG AAGCCAATTG 
GAGAAATTAG CATTTAAAGA TAAAAGACTG GATGTTGAAT TTGTTCTCTC AGCACCTATT 
TCTGAATGGA ATGGCAAACA GGGACATATT TCACCAGCTC TTCTTTCTGA ATTTTTGAAA 
AGAAATTTGG ACAAATCCAA AGTTCTCGTC TGCATTTGTG GACCAGTGCC ATTTACAGAA 
CAAGGAGTAA GGTTGCTGCA TGATCTCAAC TTTTCCAAAA ATGAGATCCA TAGTTTTACA 
GCATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Cytosolic localization of NADH cytochrome b? oxidoreductase (Ncb5or).
FEBS letters590(5)661-71(2016 Mar)
Z?mb? V,T?th M,Schlachter K,Szel?nyi P,Sarnyai F,Lotz G,Csala M,Kereszturi ?

Natural mutations lead to enhanced proteasomal degradation of human Ncb5or, a novel flavoheme reductase.
Biochimie95(7)1403-10(2013 Jul)
K?lm?n FS,Liz?k B,Nagy SK,M?sz?ros T,Z?mb? V,Mandl J,Csala M,Kereszturi E

Methemoglobin reductase deficiency: novel mutation is associated with a disease phenotype of intermediate severity.
Journal of pediatric hematology/oncology34(6)457-60(2012 Aug)
Percy MJ,Barnes C,Crighton G,Leventer RJ,Wynn R,Lappin TR

Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Diabetes care33(10)2250-3(2010 Oct)
Bailey SD,Xie C,Do R,Montpetit A,Diaz R,Mohan V,Keavney B,Yusuf S,Gerstein HC,Engert JC,Anand S,

Study of the individual cytochrome b5 and cytochrome b5 reductase domains of Ncb5or reveals a unique heme pocket and a possible role of the CS domain.
The Journal of biological chemistry285(39)30181-91(2010 Sep)
Deng B,Parthasarathy S,Wang W,Gibney BR,Battaile KP,Lovell S,Benson DR,Zhu H

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CYB5R4 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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