IER3IP1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	IER3IP1
Entrez Gene ID	51124
Full Name	immediate early response 3 interacting protein 1
Synonyms	HSPC039,MEDS,PRO2309
General protein information	Preferred Names immediate early response 3 interacting protein 1 Names immediate early response 3-interacting protein 1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 18 Map Location: 18q21.1
Summary	This gene encodes a small protein that is localized to the endoplasmic reticulum (ER) and may play a role in the ER stress response by mediating cell differentiation and apoptosis. Transcription of this gene is regulated by tumor necrosis factor alpha and specificity protein 1 (Sp1). Mutations in this gene may play a role in microcephaly, epilepsy, and diabetes syndrome (MEDS), and a pseudogene of this gene is located on the long arm of chromosome 12. [provided by RefSeq, Dec 2011].
Disorder MIM:	609382
Disorder Html:	Microcephaly, epilepsy, and diabetes syndrome, 614231 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_016097.4	NP_057181.1	immediate early response 3-interacting protein 1 precursor
NM_016097.5	NP_057181.1	immediate early response 3-interacting protein 1 precursor

Pathways from BioSystems

Homologies

Homo sapiens (human)	IER3IP1	NP_057181.1
Gallus gallus (chicken)	IER3IP1	XP_004949077.1
Danio rerio (zebrafish)	ier3ip1	NP_001239302.1
Xenopus tropicalis (tropical clawed frog)	ier3ip1	NP_001016260.1
Canis lupus familiaris (dog)	IER3IP1	XP_855203.1
Pan troglodytes (chimpanzee)	IER3IP1	XP_001141917.2
Mus musculus (house mouse)	Ier3ip1	NP_079685.1
Bos taurus (cattle)	IER3IP1	NP_001106791.1

Gene Ontology
Bibliography

Related articles in PubMed

Microcephaly with simplified gyral pattern, epilepsy and permanent neonatal diabetes syndrome (MEDS). A new patient and review of the literature.
Valenzuela I, Boronat S, Mart?nez-S?ez E, Clemente M, S?nchez-Monta?ez ?, Munell F, Carrascosa A, Macaya A
European journal of medical genetics60(10)517-520(2017 Oct)

A homozygous IER3IP1 mutation causes microcephaly with simplified gyral pattern, epilepsy, and permanent neonatal diabetes syndrome (MEDS).
Abdel-Salam GM, Schaffer AE, Zaki MS, Dixon-Salazar T, Mostafa IS, Afifi HH, Gleeson JG
American journal of medical genetics. Part A158A(11)2788-96(2012 Nov)

Microcephaly with simplified gyration, epilepsy, and infantile diabetes linked to inappropriate apoptosis of neural progenitors.
Poulton CJ, Schot R, Kia SK, Jones M, Verheijen FW, Venselaar H, de Wit MC, de Graaff E, Bertoli-Avella AM, Mancini GM
American journal of human genetics89(2)265-76(2011 Aug)

Defining the membrane proteome of NK cells.
Ghosh D, Lippert D, Krokhin O, Cortens JP, Wilkins JA
Journal of mass spectrometry : JMS45(1)1-25(2010 Jan)

[Effect of IER3IP1 gene expression on the proliferation and erythroid differentiation of K562 cells].
Lei Y, Zhang Y, Wang YQ
Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi30(6)409-13(2009 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

233 T > C mutation in the IER3IP1 causes microcephaly with simplified gyral pattern, epilepsy and permanent neonatal diabetes syndrome.
Title: Microcephaly with simplified gyral pattern, epilepsy and permanent neonatal diabetes syndrome (MEDS). A new patient and review of the literature.

We expand the phenotypic spectrum of MEDS caused by IER3IP1 gene mutations and propose that WRS and MEDS are overlapping clinical syndromes, displaying significant gene-dependent clinical variability.
Title: A homozygous IER3IP1 mutation causes microcephaly with simplified gyral pattern, epilepsy, and permanent neonatal diabetes syndrome (MEDS).

IER3IP1 gene expression is regulated by Sp1, Sp3, and the TNF-a; induction of the gene in HepG2 liver cancer cell line
Title: Transcriptional regulation of IER3IP1 gene by tumor necrosis factor-alpha and Sp family proteins.

Inhibiting the expression of IER3IP1 can inhibit erythroid differentiation and elevate the proliferation of K562 cells.
Title: [Effect of IER3IP1 gene expression on the proliferation and erythroid differentiation of K562 cells].

Matrine can inhibit the growth of K562 cells, and transiently increase the expression level of IER3IP1 gene in a dose-dependent manner.
Title: [The expression of IER3IP1 gene in K562 cells treated by matrine and its effect on the cell growth].

The following IER3IP1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the IER3IP1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu20287	NM_016097.5 Latest version!	Homo sapiens immediate early response 3 interacting protein 1 (IER3IP1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu20287	NM_016097.4	Homo sapiens immediate early response 3 interacting protein 1 (IER3IP1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

IER3IP1 ( NM_016097.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_057181.1 Homo sapiens immediate early response 3 interacting protein 1 (IER3IP1), mRNA.

Price & Availability↑

CloneID	OHu20287
Clone ID Related Accession (Same CDS sequence)	NM_016097.4 , NM_016097.5
Accession Version	NM_016097.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 249bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-10
Organism	Homo sapiens(human)
Product	immediate early response 3-interacting protein 1 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BM829309.1, AF164798.1 and AA211693.1. This sequence is a reference standard in the RefSeqGene project. On Dec 15, 2011 this sequence version replaced NM_016097.3. ##Evidence-Data-START## Transcript exon combination :: BM829309.1, SRR1803616.125839.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2150385, SAMEA2159080 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCCTTTA CCCTGTACTC ACTGCTGCAG GCAGCCCTGC TCTGCGTCAA CGCCATCGCA 
GTGCTGCACG AGGAGCGATT CCTCAAGAAC ATTGGCTGGG GAACAGACCA GGGAATTGGT 
GGATTTGGAG AAGAGCCGGG AATTAAATCA CAGCTAATGA ACCTTATTCG ATCTGTAAGA 
ACCGTGATGA GAGTGCCATT GATAATAGTA AACTCAATTG CAATTGTGTT ACTTTTATTA 
TTTGGATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_057181.1
CDS	98..346
Translation	MAFTLYSLLQAALLCVNAIAVLHEERFLKNIGWGTDQGIGGFGEEPGIKSQLMNLIRSVRTVMRVPLIIVNSIAIVLLLLFG

Target ORF information:

RefSeq Version	NM_016097.4
Organism	Homo sapiens(human)
Definition	Homo sapiens immediate early response 3 interacting protein 1 (IER3IP1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_016097.4

ORF Insert Sequence:

ATGGCCTTTA CCCTGTACTC ACTGCTGCAG GCAGCCCTGC TCTGCGTCAA CGCCATCGCA 
GTGCTGCACG AGGAGCGATT CCTCAAGAAC ATTGGCTGGG GAACAGACCA GGGAATTGGT 
GGATTTGGAG AAGAGCCGGG AATTAAATCA CAGCTAATGA ACCTTATTCG ATCTGTAAGA 
ACCGTGATGA GAGTGCCATT GATAATAGTA AACTCAATTG CAATTGTGTT ACTTTTATTA 
TTTGGATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

IER3IP1 ( NM_016097.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_057181.1 Homo sapiens immediate early response 3 interacting protein 1 (IER3IP1), mRNA.

Price & Availability↑

CloneID	OHu20287
Clone ID Related Accession (Same CDS sequence)	NM_016097.4 , NM_016097.5
Accession Version	NM_016097.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 249bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Homo sapiens(human)
Product	immediate early response 3-interacting protein 1 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BM829309.1, AF164798.1, AA211693.1 and AC051635.7. This sequence is a reference standard in the RefSeqGene project. On Nov 23, 2018 this sequence version replaced NM_016097.4. ##Evidence-Data-START## Transcript exon combination :: AK027108.1, SRR1803617.7722.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2159080, SAMEA2467146 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000256433.6/ ENSP00000256433.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCCTTTA CCCTGTACTC ACTGCTGCAG GCAGCCCTGC TCTGCGTCAA CGCCATCGCA 
GTGCTGCACG AGGAGCGATT CCTCAAGAAC ATTGGCTGGG GAACAGACCA GGGAATTGGT 
GGATTTGGAG AAGAGCCGGG AATTAAATCA CAGCTAATGA ACCTTATTCG ATCTGTAAGA 
ACCGTGATGA GAGTGCCATT GATAATAGTA AACTCAATTG CAATTGTGTT ACTTTTATTA 
TTTGGATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_057181.1
CDS	88..336
Translation	MAFTLYSLLQAALLCVNAIAVLHEERFLKNIGWGTDQGIGGFGEEPGIKSQLMNLIRSVRTVMRVPLIIVNSIAIVLLLLFG

Target ORF information:

RefSeq Version	NM_016097.5
Organism	Homo sapiens(human)
Definition	Homo sapiens immediate early response 3 interacting protein 1 (IER3IP1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_016097.5

ORF Insert Sequence:

ATGGCCTTTA CCCTGTACTC ACTGCTGCAG GCAGCCCTGC TCTGCGTCAA CGCCATCGCA 
GTGCTGCACG AGGAGCGATT CCTCAAGAAC ATTGGCTGGG GAACAGACCA GGGAATTGGT 
GGATTTGGAG AAGAGCCGGG AATTAAATCA CAGCTAATGA ACCTTATTCG ATCTGTAAGA 
ACCGTGATGA GAGTGCCATT GATAATAGTA AACTCAATTG CAATTGTGTT ACTTTTATTA 
TTTGGATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Microcephaly with simplified gyral pattern, epilepsy and permanent neonatal diabetes syndrome (MEDS). A new patient and review of the literature.
European journal of medical genetics60(10)517-520(2017 Oct)
Valenzuela I,Boronat S,Mart?nez-S?ez E,Clemente M,S?nchez-Monta?ez ?,Munell F,Carrascosa A,Macaya A

A homozygous IER3IP1 mutation causes microcephaly with simplified gyral pattern, epilepsy, and permanent neonatal diabetes syndrome (MEDS).
American journal of medical genetics. Part A158A(11)2788-96(2012 Nov)
Abdel-Salam GM,Schaffer AE,Zaki MS,Dixon-Salazar T,Mostafa IS,Afifi HH,Gleeson JG

Microcephaly with simplified gyration, epilepsy, and infantile diabetes linked to inappropriate apoptosis of neural progenitors.
American journal of human genetics89(2)265-76(2011 Aug)
Poulton CJ,Schot R,Kia SK,Jones M,Verheijen FW,Venselaar H,de Wit MC,de Graaff E,Bertoli-Avella AM,Mancini GM

Defining the membrane proteome of NK cells.
Journal of mass spectrometry : JMS45(1)1-25(2010 Jan)
Ghosh D,Lippert D,Krokhin O,Cortens JP,Wilkins JA

[Effect of IER3IP1 gene expression on the proliferation and erythroid differentiation of K562 cells].
Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi30(6)409-13(2009 Jun)
Lei Y,Zhang Y,Wang YQ

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IER3IP1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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