SBDS cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	SBDS
Entrez Gene ID	51119
Full Name	SBDS, ribosome maturation factor
Synonyms	CGI-97,SDS,SWDS
General protein information	Preferred Names SBDS, ribosome maturation factor Names ribosome maturation protein SBDS SBDS, ribosome assembly guanine nucleotide exchange factor
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 7 Map Location: 7q11.21
Summary	This gene encodes a highly conserved protein that plays an essential role in ribosome biogenesis. The encoded protein interacts with elongation factor-like GTPase 1 to disassociate eukaryotic initiation factor 6 from the late cytoplasmic pre-60S ribosomal subunit allowing assembly of the 80S subunit. Mutations within this gene are associated with the autosomal recessive disorder Shwachman-Bodian-Diamond syndrome. This gene has a closely linked pseudogene that is distally located. [provided by RefSeq, Jan 2017].
Disorder MIM:	607444
Disorder Html:	Shwachman-Diamond syndrome, 260400 (3); {Aplastic anemia, susceptibility to}, 609135 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_016038.3	NP_057122.2	ribosome maturation protein SBDS
NM_016038.2	NP_057122.2	ribosome maturation protein SBDS
NM_016038.4	NP_057122.2	ribosome maturation protein SBDS

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	SBDS	XP_848632.1
Drosophila melanogaster (fruit fly)	CG8549	NP_001261482.1
Kluyveromyces lactis	KLLA0F15532g	XP_455778.1
Neurospora crassa	NCU00476	XP_956795.1
Pan troglodytes (chimpanzee)	SBDS	XP_519568.2
Gallus gallus (chicken)	SBDS	NP_001006211.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP007882	XP_317609.3
Caenorhabditis elegans (roundworm)	sbds-1	NP_497226.2
Gallus gallus (chicken)	LOC100858362	XP_003642436.1
Eremothecium gossypii	AGOS_AAL154C	NP_982388.1
Schizosaccharomyces pombe (fission yeast)	sdo1	NP_593869.1
Magnaporthe oryzae (rice blast fungus)	MGG_05662	XP_003710560.1
Homo sapiens (human)	SBDS	NP_057122.2
Rattus norvegicus (Norway rat)	Sbds	NP_001008290.1
Danio rerio (zebrafish)	sbds	NP_957415.1
Arabidopsis thaliana (thale cress)	AT1G43860	NP_564488.1
Oryza sativa (rice)	Os08g0107500	NP_001060798.1
Bos taurus (cattle)	SBDS	NP_001029611.1
Mus musculus (house mouse)	Sbds	NP_075737.1
Saccharomyces cerevisiae (baker's yeast)	SDO1	NP_013122.1
Xenopus tropicalis (tropical clawed frog)	sbds	NP_001004953.1

Gene Ontology
Bibliography

Related articles in PubMed

Ataluren-driven Restoration of Shwachman-Bodian-Diamond Syndrome Protein Function in Shwachman-Diamond Syndrome Bone Marrow Cells.
Bezzerri V, Bardelli D, Morini J, Vella A, Cesaro S, Sorio C, Biondi A, Danesino C, Farruggia P, Assael BM, D'Amico G, Cipolli M
American journal of hematology(2017 Dec)

The Greek Registry of Shwachman Diamond-Syndrome: Molecular and clinical data.
Delaporta P, Sofocleous C, Economou M, Makis A, Kostaridou S, Kattamis A
Pediatric blood & cancer64(11)(2017 Nov)

Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.
Yang X, Coulombe-Huntington J, Kang S, Sheynkman GM, Hao T, Richardson A, Sun S, Yang F, Shen YA, Murray RR, Spirohn K, Begg BE, Duran-Frigola M, MacWilliams A, Pevzner SJ, Zhong Q, Trigg SA, Tam S, Ghamsari L, Sahni N, Yi S, Rodriguez MD, Balcha D, Tan G, Costanzo M, Andrews B, Boone C, Zhou XJ, Salehi-Ashtiani K, Charloteaux B, Chen AA, Calderwood MA, Aloy P, Roth FP, Hill DE, Iakoucheva LM, Xia Y, Vidal M
Cell164(4)805-17(2016 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

SBDS mutation is associated with Shwachman Diamond-Syndrome.
Title: The Greek Registry of Shwachman Diamond-Syndrome: Molecular and clinical data.

SBDS function is specifically required for efficient translation re-initiation into the protein isoforms C/EBPalpha-p30 and C/EBPbeta-LIP, which is controlled by a single cis-regulatory upstream open reading frame (uORF) in the 5' untranslated regions (5' UTRs) of both mRNAs.
Title: Shwachman-Bodian-Diamond syndrome (SBDS) protein deficiency impairs translation re-initiation from C/EBP? and C/EBP? mRNAs.

The clinical diagnosis was confirmed by detection of compound heterozygous mutations in SBDS using whole-exome sequencing: a recurrent intronic mutation causing aberrant splicing (c.258+2T>C) and a novel missense variant in a highly conserved codon (c.41A>G, p.Asn14Ser), considered to be damaging for the protein structure by in silico prediction programs
Title: Novel myopathy in a newborn with Shwachman-Diamond syndrome and review of neonatal presentation.

Upon EFL1 binding, SBDS is repositioned around helix 69, thus facilitating a conformational switch in EFL1 that displaces eIF6 by competing for an overlapping binding site on the 60S ribosomal subunit.
Title: Mechanism of eIF6 release from the nascent 60S ribosomal subunit.

Association of Elongation Factor-like 1 (EFL1) GTPase to SBDS did not modify the affinity for GTP but dramatically decreased that for GDP by increasing the dissociation rate of the nucleotide.
Title: Defective Guanine Nucleotide Exchange in the Elongation Factor-like 1 (EFL1) GTPase by Mutations in the Shwachman-Diamond Syndrome Protein.

The following SBDS gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SBDS cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu18189	NM_016038.4 Latest version!	Homo sapiens SBDS ribosome maturation factor (SBDS), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu18189	NM_016038.2	Homo sapiens Shwachman-Bodian-Diamond syndrome (SBDS), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu18189	NM_016038.3	Homo sapiens SBDS, ribosome maturation factor (SBDS), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

SBDS ( NM_016038.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_057122.2 Homo sapiens SBDS, ribosome maturation factor (SBDS), mRNA.

Price & Availability↑

CloneID	OHu18189
Clone ID Related Accession (Same CDS sequence)	NM_016038.3 , NM_016038.2 , NM_016038.4
Accession Version	NM_016038.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 753bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-27
Organism	Homo sapiens(human)
Product	ribosome maturation protein SBDS
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC079920.6, AK289609.1, AY169963.1 and DB558666.1. On Feb 8, 2017 this sequence version replaced NM_016038.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660803.73944.1, SRR1803616.121661.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1970526, SAMEA2144333 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTCGATCT TCACCCCCAC CAACCAGATC CGCCTAACCA ATGTGGCCGT GGTACGGATG 
AAGCGTGCCG GGAAGCGCTT CGAAATCGCC TGCTACAAAA ACAAGGTCGT CGGCTGGCGG 
AGCGGCGTGG AAAAAGACCT CGATGAAGTT CTGCAGACCC ACTCAGTGTT TGTAAATGTT 
TCTAAAGGTC AGGTTGCCAA AAAGGAAGAT CTCATCAGTG CGTTTGGAAC AGATGACCAA 
ACTGAAATCT GTAAGCAGAT TTTGACTAAA GGAGAAGTTC AAGTATCAGA TAAAGAAAGA 
CACACACAAC TGGAGCAGAT GTTTAGGGAC ATTGCAACTA TTGTGGCAGA CAAATGTGTG 
AATCCTGAAA CAAAGAGACC ATACACCGTG ATCCTTATTG AGAGAGCCAT GAAGGACATC 
CACTATTCGG TGAAAACCAA CAAGAGTACA AAACAGCAGG CTTTGGAAGT GATAAAGCAG 
TTAAAAGAGA AAATGAAGAT AGAACGTGCT CACATGAGGC TTCGGTTCAT CCTTCCAGTC 
AATGAAGGCA AGAAGCTGAA AGAAAAGCTC AAGCCACTGA TCAAGGTCAT AGAAAGTGAA 
GATTATGGCC AACAGTTAGA AATCGTATGT CTGATTGACC CGGGCTGCTT CCGAGAAATT 
GATGAGCTAA TAAAAAAGGA AACTAAAGGC AAAGGTTCTT TGGAAGTACT CAATCTGAAA 
GATGTAGAAG AAGGAGATGA GAAATTTGAA TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_057122.2
CDS	280..1032
Translation	MSIFTPTNQIRLTNVAVVRMKRAGKRFEIACYKNKVVGWRSGVEKDLDEVLQTHSVFVNVSKGQVAKKEDLISAFGTDDQTEICKQILTKGEVQVSDKERHTQLEQMFRDIATIVADKCVNPETKRPYTVILIERAMKDIHYSVKTNKSTKQQALEVIKQLKEKMKIERAHMRLRFILPVNEGKKLKEKLKPLIKVIESEDYGQQLEIVCLIDPGCFREIDELIKKETKGKGSLEVLNLKDVEEGDEKFE

Target ORF information:

RefSeq Version	NM_016038.3
Organism	Homo sapiens(human)
Definition	Homo sapiens SBDS, ribosome maturation factor (SBDS), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_016038.3

ORF Insert Sequence:

ATGTCGATCT TCACCCCCAC CAACCAGATC CGCCTAACCA ATGTGGCCGT GGTACGGATG 
AAGCGTGCCG GGAAGCGCTT CGAAATCGCC TGCTACAAAA ACAAGGTCGT CGGCTGGCGG 
AGCGGCGTGG AAAAAGACCT CGATGAAGTT CTGCAGACCC ACTCAGTGTT TGTAAATGTT 
TCTAAAGGTC AGGTTGCCAA AAAGGAAGAT CTCATCAGTG CGTTTGGAAC AGATGACCAA 
ACTGAAATCT GTAAGCAGAT TTTGACTAAA GGAGAAGTTC AAGTATCAGA TAAAGAAAGA 
CACACACAAC TGGAGCAGAT GTTTAGGGAC ATTGCAACTA TTGTGGCAGA CAAATGTGTG 
AATCCTGAAA CAAAGAGACC ATACACCGTG ATCCTTATTG AGAGAGCCAT GAAGGACATC 
CACTATTCGG TGAAAACCAA CAAGAGTACA AAACAGCAGG CTTTGGAAGT GATAAAGCAG 
TTAAAAGAGA AAATGAAGAT AGAACGTGCT CACATGAGGC TTCGGTTCAT CCTTCCAGTC 
AATGAAGGCA AGAAGCTGAA AGAAAAGCTC AAGCCACTGA TCAAGGTCAT AGAAAGTGAA 
GATTATGGCC AACAGTTAGA AATCGTATGT CTGATTGACC CGGGCTGCTT CCGAGAAATT 
GATGAGCTAA TAAAAAAGGA AACTAAAGGC AAAGGTTCTT TGGAAGTACT CAATCTGAAA 
GATGTAGAAG AAGGAGATGA GAAATTTGAA TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SBDS ( NM_016038.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_057122.2 Homo sapiens Shwachman-Bodian-Diamond syndrome (SBDS), mRNA.

Price & Availability↑

CloneID	OHu18189
Clone ID Related Accession (Same CDS sequence)	NM_016038.3 , NM_016038.2 , NM_016038.4
Accession Version	NM_016038.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 753bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-03-14
Organism	Homo sapiens(Human)
Product	ribosome maturation protein SBDS
Comment

ATGTCGATCT TCACCCCCAC CAACCAGATC CGCCTAACCA ATGTGGCCGT GGTACGGATG 
AAGCGTGCCG GGAAGCGCTT CGAAATCGCC TGCTACAAAA ACAAGGTCGT CGGCTGGCGG 
AGCGGCGTGG AAAAAGACCT CGATGAAGTT CTGCAGACCC ACTCAGTGTT TGTAAATGTT 
TCTAAAGGTC AGGTTGCCAA AAAGGAAGAT CTCATCAGTG CGTTTGGAAC AGATGACCAA 
ACTGAAATCT GTAAGCAGAT TTTGACTAAA GGAGAAGTTC AAGTATCAGA TAAAGAAAGA 
CACACACAAC TGGAGCAGAT GTTTAGGGAC ATTGCAACTA TTGTGGCAGA CAAATGTGTG 
AATCCTGAAA CAAAGAGACC ATACACCGTG ATCCTTATTG AGAGAGCCAT GAAGGACATC 
CACTATTCGG TGAAAACCAA CAAGAGTACA AAACAGCAGG CTTTGGAAGT GATAAAGCAG 
TTAAAAGAGA AAATGAAGAT AGAACGTGCT CACATGAGGC TTCGGTTCAT CCTTCCAGTC 
AATGAAGGCA AGAAGCTGAA AGAAAAGCTC AAGCCACTGA TCAAGGTCAT AGAAAGTGAA 
GATTATGGCC AACAGTTAGA AATCGTATGT CTGATTGACC CGGGCTGCTT CCGAGAAATT 
GATGAGCTAA TAAAAAAGGA AACTAAAGGC AAAGGTTCTT TGGAAGTACT CAATCTGAAA 
GATGTAGAAG AAGGAGATGA GAAATTTGAA TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_057122.2
Translation	MSIFTPTNQIRLTNVAVVRMKRAGKRFEIACYKNKVVGWRSGVEKDLDEVLQTHSVFVNVSKGQVAKKEDLISAFGTDDQTEICKQILTKGEVQVSDKERHTQLEQMFRDIATIVADKCVNPETKRPYTVILIERAMKDIHYSVKTNKSTKQQALEVIKQLKEKMKIERAHMRLRFILPVNEGKKLKEKLKPLIKVIESEDYGQQLEIVCLIDPGCFREIDELIKKETKGKGSLEVLNLKDVEEGDEKFE

Target ORF information:

RefSeq Version	NM_016038.2
Organism	Homo sapiens(Human)
Definition	Homo sapiens Shwachman-Bodian-Diamond syndrome (SBDS), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_016038.2

ORF Insert Sequence:

ATGTCGATCT TCACCCCCAC CAACCAGATC CGCCTAACCA ATGTGGCCGT GGTACGGATG 
AAGCGTGCCG GGAAGCGCTT CGAAATCGCC TGCTACAAAA ACAAGGTCGT CGGCTGGCGG 
AGCGGCGTGG AAAAAGACCT CGATGAAGTT CTGCAGACCC ACTCAGTGTT TGTAAATGTT 
TCTAAAGGTC AGGTTGCCAA AAAGGAAGAT CTCATCAGTG CGTTTGGAAC AGATGACCAA 
ACTGAAATCT GTAAGCAGAT TTTGACTAAA GGAGAAGTTC AAGTATCAGA TAAAGAAAGA 
CACACACAAC TGGAGCAGAT GTTTAGGGAC ATTGCAACTA TTGTGGCAGA CAAATGTGTG 
AATCCTGAAA CAAAGAGACC ATACACCGTG ATCCTTATTG AGAGAGCCAT GAAGGACATC 
CACTATTCGG TGAAAACCAA CAAGAGTACA AAACAGCAGG CTTTGGAAGT GATAAAGCAG 
TTAAAAGAGA AAATGAAGAT AGAACGTGCT CACATGAGGC TTCGGTTCAT CCTTCCAGTC 
AATGAAGGCA AGAAGCTGAA AGAAAAGCTC AAGCCACTGA TCAAGGTCAT AGAAAGTGAA 
GATTATGGCC AACAGTTAGA AATCGTATGT CTGATTGACC CGGGCTGCTT CCGAGAAATT 
GATGAGCTAA TAAAAAAGGA AACTAAAGGC AAAGGTTCTT TGGAAGTACT CAATCTGAAA 
GATGTAGAAG AAGGAGATGA GAAATTTGAA TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SBDS ( NM_016038.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_057122.2 Homo sapiens SBDS ribosome maturation factor (SBDS), mRNA.

Price & Availability↑

CloneID	OHu18189
Clone ID Related Accession (Same CDS sequence)	NM_016038.3 , NM_016038.2 , NM_016038.4
Accession Version	NM_016038.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 753bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-06
Organism	Homo sapiens(human)
Product	ribosome maturation protein SBDS
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK289609.1, AY169963.1, AC079920.6 and DB558666.1. On Nov 23, 2018 this sequence version replaced NM_016038.3. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR5189652.125831.1, SRR3476690.331574.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1970526, SAMEA2144333 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000246868.7/ ENSP00000246868.2 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGTCGATCT TCACCCCCAC CAACCAGATC CGCCTAACCA ATGTGGCCGT GGTACGGATG 
AAGCGTGCCG GGAAGCGCTT CGAAATCGCC TGCTACAAAA ACAAGGTCGT CGGCTGGCGG 
AGCGGCGTGG AAAAAGACCT CGATGAAGTT CTGCAGACCC ACTCAGTGTT TGTAAATGTT 
TCTAAAGGTC AGGTTGCCAA AAAGGAAGAT CTCATCAGTG CGTTTGGAAC AGATGACCAA 
ACTGAAATCT GTAAGCAGAT TTTGACTAAA GGAGAAGTTC AAGTATCAGA TAAAGAAAGA 
CACACACAAC TGGAGCAGAT GTTTAGGGAC ATTGCAACTA TTGTGGCAGA CAAATGTGTG 
AATCCTGAAA CAAAGAGACC ATACACCGTG ATCCTTATTG AGAGAGCCAT GAAGGACATC 
CACTATTCGG TGAAAACCAA CAAGAGTACA AAACAGCAGG CTTTGGAAGT GATAAAGCAG 
TTAAAAGAGA AAATGAAGAT AGAACGTGCT CACATGAGGC TTCGGTTCAT CCTTCCAGTC 
AATGAAGGCA AGAAGCTGAA AGAAAAGCTC AAGCCACTGA TCAAGGTCAT AGAAAGTGAA 
GATTATGGCC AACAGTTAGA AATCGTATGT CTGATTGACC CGGGCTGCTT CCGAGAAATT 
GATGAGCTAA TAAAAAAGGA AACTAAAGGC AAAGGTTCTT TGGAAGTACT CAATCTGAAA 
GATGTAGAAG AAGGAGATGA GAAATTTGAA TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_057122.2
CDS	170..922
Translation	MSIFTPTNQIRLTNVAVVRMKRAGKRFEIACYKNKVVGWRSGVEKDLDEVLQTHSVFVNVSKGQVAKKEDLISAFGTDDQTEICKQILTKGEVQVSDKERHTQLEQMFRDIATIVADKCVNPETKRPYTVILIERAMKDIHYSVKTNKSTKQQALEVIKQLKEKMKIERAHMRLRFILPVNEGKKLKEKLKPLIKVIESEDYGQQLEIVCLIDPGCFREIDELIKKETKGKGSLEVLNLKDVEEGDEKFE

Target ORF information:

RefSeq Version	NM_016038.4
Organism	Homo sapiens(human)
Definition	Homo sapiens SBDS ribosome maturation factor (SBDS), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_016038.4

ORF Insert Sequence:

ATGTCGATCT TCACCCCCAC CAACCAGATC CGCCTAACCA ATGTGGCCGT GGTACGGATG 
AAGCGTGCCG GGAAGCGCTT CGAAATCGCC TGCTACAAAA ACAAGGTCGT CGGCTGGCGG 
AGCGGCGTGG AAAAAGACCT CGATGAAGTT CTGCAGACCC ACTCAGTGTT TGTAAATGTT 
TCTAAAGGTC AGGTTGCCAA AAAGGAAGAT CTCATCAGTG CGTTTGGAAC AGATGACCAA 
ACTGAAATCT GTAAGCAGAT TTTGACTAAA GGAGAAGTTC AAGTATCAGA TAAAGAAAGA 
CACACACAAC TGGAGCAGAT GTTTAGGGAC ATTGCAACTA TTGTGGCAGA CAAATGTGTG 
AATCCTGAAA CAAAGAGACC ATACACCGTG ATCCTTATTG AGAGAGCCAT GAAGGACATC 
CACTATTCGG TGAAAACCAA CAAGAGTACA AAACAGCAGG CTTTGGAAGT GATAAAGCAG 
TTAAAAGAGA AAATGAAGAT AGAACGTGCT CACATGAGGC TTCGGTTCAT CCTTCCAGTC 
AATGAAGGCA AGAAGCTGAA AGAAAAGCTC AAGCCACTGA TCAAGGTCAT AGAAAGTGAA 
GATTATGGCC AACAGTTAGA AATCGTATGT CTGATTGACC CGGGCTGCTT CCGAGAAATT 
GATGAGCTAA TAAAAAAGGA AACTAAAGGC AAAGGTTCTT TGGAAGTACT CAATCTGAAA 
GATGTAGAAG AAGGAGATGA GAAATTTGAA TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Ataluren-driven Restoration of Shwachman-Bodian-Diamond Syndrome Protein Function in Shwachman-Diamond Syndrome Bone Marrow Cells.
American journal of hematology(2017 Dec)
Bezzerri V,Bardelli D,Morini J,Vella A,Cesaro S,Sorio C,Biondi A,Danesino C,Farruggia P,Assael BM,D'Amico G,Cipolli M

The Greek Registry of Shwachman Diamond-Syndrome: Molecular and clinical data.
Pediatric blood & cancer64(11)(2017 Nov)
Delaporta P,Sofocleous C,Economou M,Makis A,Kostaridou S,Kattamis A

Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.
Cell164(4)805-17(2016 Feb)
Yang X,Coulombe-Huntington J,Kang S,Sheynkman GM,Hao T,Richardson A,Sun S,Yang F,Shen YA,Murray RR,Spirohn K,Begg BE,Duran-Frigola M,MacWilliams A,Pevzner SJ,Zhong Q,Trigg SA,Tam S,Ghamsari L,Sahni N,Yi S,Rodriguez MD,Balcha D,Tan G,Costanzo M,Andrews B,Boone C,Zhou XJ,Salehi-Ashtiani K,Charloteaux B,Chen AA,Calderwood MA,Aloy P,Roth FP,Hill DE,Iakoucheva LM,Xia Y,Vidal M

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SBDS cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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