Gene Symbol | PCNA |
Entrez Gene ID | 5111 |
Full Name | proliferating cell nuclear antigen |
Synonyms | ATLD2 |
General protein information |
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Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Summary | The protein encoded by this gene is found in the nucleus and is a cofactor of DNA polymerase delta. The encoded protein acts as a homotrimer and helps increase the processivity of leading strand synthesis during DNA replication. In response to DNA damage, this protein is ubiquitinated and is involved in the RAD6-dependent DNA repair pathway. Two transcript variants encoding the same protein have been found for this gene. Pseudogenes of this gene have been described on chromosome 4 and on the X chromosome. [provided by RefSeq, Jul 2008]. |
Disorder MIM: | |
Disorder Html: | ?Ataxia-telangiectasia-like disorder 2, 615919 (3) |