GAL cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	GAL
Entrez Gene ID	51083
Full Name	galanin and GMAP prepropeptide
Synonyms	ETL8,GAL-GMAP,GALN,GLNN,GMAP
General protein information	Preferred Names galanin and GMAP prepropeptide Names galanin peptides galanin prepropeptide galanin-message-associated peptide galanin-related peptide galanin/GMAP prepropeptide
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 11 Map Location: 11q13.2
Summary	This gene encodes a neuroendocrine peptide that is widely expressed in the central and peripheral nervous systems and also the gastrointestinal tract, pancreas, adrenal gland and urogenital tract. The encoded protein is a precursor that is proteolytically processed to generate two mature peptides: galanin and galanin message-associated peptide (GMAP). Galanin has diverse physiological functions including nociception, feeding and energy homeostasis, osmotic regulation and water balance. GMAP has been demonstrated to possess antifungal activity and hypothesized to be part of the innate immune system. [provided by RefSeq, Jul 2015].
Disorder MIM:	137035
Disorder Html:	?Epilepsy, familial temporal lobe, 8, 616461 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_015973.4	NP_057057.2	galanin peptides preproprotein
NM_015973.5	NP_057057.2	galanin peptides preproprotein

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	GAL	XP_001173776.1
Mus musculus (house mouse)	Gal	NP_034383.1
Bos taurus (cattle)	GAL	NP_776339.1
Canis lupus familiaris (dog)	GAL	XP_854576.3
Homo sapiens (human)	GAL	NP_057057.2
Rattus norvegicus (Norway rat)	Gal	NP_150240.1

Gene Ontology
Bibliography

Related articles in PubMed

Jun, Gal, Cd74, and C1qb as potential indicator for neuropathic pain.
Yang JA, He JM, Lu JM, Ji LJ
Journal of cellular biochemistry(2018 Jan)

The neuropeptide galanin promotes an anti-thrombotic phenotype on endocardial endothelial cells from heart failure patients.
Tyrrell C, Toyooka A, Khan F, Thornburg KL, Mudd JO, Hasan W
Autonomic neuroscience : basic & clinical20635-42(2017 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Study found dramatic reduction in von Willebrand factor extrusion and multimer expression by the neuropeptide galanin in cultured endocardial endothelial cells from heart failure patients. Results suggest that a combination of beta-blockers and galanin therapy may be one therapeutic option for improving endocardial endothelial anticoagulant function.
Title: The neuropeptide galanin promotes an anti-thrombotic phenotype on endocardial endothelial cells from heart failure patients.

Our results identified FGL2, GAL, SEMA4D, SEMA7A, and IDO1 as new candidate genes that could be involved in MSCs-mediated immunomodulation. FGL2, GAL, SEMA4D, SEMA7A, and IDO1 genes appeared to be differentially transcribed in the different MSC populations. Moreover, these genes were not similarly modulated following MSCs-exposure to inflammatory signals
Title: Identification and Evaluation of New Immunoregulatory Genes in Mesenchymal Stromal Cells of Different Origins: Comparison of Normal and Inflammatory Conditions.

Study provides evidence that GAL and GALR1/2 genes were identified as aberrantly methylated in head and neck squamous cell carcinoma.
Title: Site-specific methylation patterns of the GAL and GALR1/2 genes in head and neck cancer: Potential utility as biomarkers for prognosis.

The analyses revealed that the presence of the galanin gene minor allele (G) increased susceptibility to multiple sclerosis in men (OR = 2.49, P = 0.008) but not in women.
Title: Single-nucleotide polymorphism rs948854 in human galanin gene and multiple sclerosis: a gender-specific risk factor.

Low levels of plasma galanin is associated with obese subjects with hypertension.
Title: Low levels of plasma galanin in obese subjects with hypertension.

The following GAL gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the GAL cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu07193	NM_015973.5 Latest version!	Homo sapiens galanin and GMAP prepropeptide (GAL), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu07193	NM_015973.4	Homo sapiens galanin and GMAP prepropeptide (GAL), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

GAL ( NM_015973.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_057057.2 Homo sapiens galanin and GMAP prepropeptide (GAL), mRNA.

Price & Availability↑

CloneID	OHu07193
Clone ID Related Accession (Same CDS sequence)	NM_015973.4 , NM_015973.5
Accession Version	NM_015973.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 372bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-10
Organism	Homo sapiens(human)
Product	galanin peptides preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AP003096.3, BM846531.1 and BC030241.1. This sequence is a reference standard in the RefSeqGene project. On Jul 30, 2015 this sequence version replaced NM_015973.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AL556409.3, CX163692.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END##

ATGGCCCGAG GCAGCGCCCT CCTGCTCGCC TCCCTCCTCC TCGCCGCGGC CCTTTCTGCC 
TCTGCGGGGC TCTGGTCGCC GGCCAAGGAA AAACGAGGCT GGACCCTGAA CAGCGCGGGC 
TACCTGCTGG GCCCACATGC CGTTGGCAAC CACAGGTCAT TCAGCGACAA GAATGGCCTC 
ACCAGCAAGC GGGAGCTGCG GCCCGAAGAT GACATGAAAC CAGGAAGCTT TGACAGGTCC 
ATACCTGAAA ACAATATCAT GCGCACAATC ATTGAGTTTC TGTCTTTCTT GCATCTCAAA 
GAGGCCGGTG CCCTCGACCG CCTCCTGGAT CTCCCCGCCG CAGCCTCCTC AGAAGACATC 
GAGCGGTCCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_057057.2
CDS	259..630
Translation	MARGSALLLASLLLAAALSASAGLWSPAKEKRGWTLNSAGYLLGPHAVGNHRSFSDKNGLTSKRELRPEDDMKPGSFDRSIPENNIMRTIIEFLSFLHLKEAGALDRLLDLPAAASSEDIERS

Target ORF information:

RefSeq Version	NM_015973.4
Organism	Homo sapiens(human)
Definition	Homo sapiens galanin and GMAP prepropeptide (GAL), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_015973.4

ORF Insert Sequence:

ATGGCCCGAG GCAGCGCCCT CCTGCTCGCC TCCCTCCTCC TCGCCGCGGC CCTTTCTGCC 
TCTGCGGGGC TCTGGTCGCC GGCCAAGGAA AAACGAGGCT GGACCCTGAA CAGCGCGGGC 
TACCTGCTGG GCCCACATGC CGTTGGCAAC CACAGGTCAT TCAGCGACAA GAATGGCCTC 
ACCAGCAAGC GGGAGCTGCG GCCCGAAGAT GACATGAAAC CAGGAAGCTT TGACAGGTCC 
ATACCTGAAA ACAATATCAT GCGCACAATC ATTGAGTTTC TGTCTTTCTT GCATCTCAAA 
GAGGCCGGTG CCCTCGACCG CCTCCTGGAT CTCCCCGCCG CAGCCTCCTC AGAAGACATC 
GAGCGGTCCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

GAL ( NM_015973.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_057057.2 Homo sapiens galanin and GMAP prepropeptide (GAL), mRNA.

Price & Availability↑

CloneID	OHu07193
Clone ID Related Accession (Same CDS sequence)	NM_015973.4 , NM_015973.5
Accession Version	NM_015973.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 372bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Homo sapiens(human)
Product	galanin peptides preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BM846531.1 and BC030241.1. This sequence is a reference standard in the RefSeqGene project. On Nov 22, 2018 this sequence version replaced NM_015973.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AL556409.3, CX163692.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000265643.4/ ENSP00000265643.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCCCGAG GCAGCGCCCT CCTGCTCGCC TCCCTCCTCC TCGCCGCGGC CCTTTCTGCC 
TCTGCGGGGC TCTGGTCGCC GGCCAAGGAA AAACGAGGCT GGACCCTGAA CAGCGCGGGC 
TACCTGCTGG GCCCACATGC CGTTGGCAAC CACAGGTCAT TCAGCGACAA GAATGGCCTC 
ACCAGCAAGC GGGAGCTGCG GCCCGAAGAT GACATGAAAC CAGGAAGCTT TGACAGGTCC 
ATACCTGAAA ACAATATCAT GCGCACAATC ATTGAGTTTC TGTCTTTCTT GCATCTCAAA 
GAGGCCGGTG CCCTCGACCG CCTCCTGGAT CTCCCCGCCG CAGCCTCCTC AGAAGACATC 
GAGCGGTCCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_057057.2
CDS	190..561
Translation	MARGSALLLASLLLAAALSASAGLWSPAKEKRGWTLNSAGYLLGPHAVGNHRSFSDKNGLTSKRELRPEDDMKPGSFDRSIPENNIMRTIIEFLSFLHLKEAGALDRLLDLPAAASSEDIERS

Target ORF information:

RefSeq Version	NM_015973.5
Organism	Homo sapiens(human)
Definition	Homo sapiens galanin and GMAP prepropeptide (GAL), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_015973.5

ORF Insert Sequence:

ATGGCCCGAG GCAGCGCCCT CCTGCTCGCC TCCCTCCTCC TCGCCGCGGC CCTTTCTGCC 
TCTGCGGGGC TCTGGTCGCC GGCCAAGGAA AAACGAGGCT GGACCCTGAA CAGCGCGGGC 
TACCTGCTGG GCCCACATGC CGTTGGCAAC CACAGGTCAT TCAGCGACAA GAATGGCCTC 
ACCAGCAAGC GGGAGCTGCG GCCCGAAGAT GACATGAAAC CAGGAAGCTT TGACAGGTCC 
ATACCTGAAA ACAATATCAT GCGCACAATC ATTGAGTTTC TGTCTTTCTT GCATCTCAAA 
GAGGCCGGTG CCCTCGACCG CCTCCTGGAT CTCCCCGCCG CAGCCTCCTC AGAAGACATC 
GAGCGGTCCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Jun, Gal, Cd74, and C1qb as potential indicator for neuropathic pain.
Journal of cellular biochemistry(2018 Jan)
Yang JA,He JM,Lu JM,Ji LJ

The neuropeptide galanin promotes an anti-thrombotic phenotype on endocardial endothelial cells from heart failure patients.
Autonomic neuroscience : basic & clinical20635-42(2017 Sep)
Tyrrell C,Toyooka A,Khan F,Thornburg KL,Mudd JO,Hasan W

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GAL cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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