MRPS7 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	MRPS7
Entrez Gene ID	51081
Full Name	mitochondrial ribosomal protein S7
Synonyms	MRP-S,MRP-S7,RP-S7,RPMS7,S7mt,bMRP27a
General protein information	Preferred Names mitochondrial ribosomal protein S7 Names 28S ribosomal protein S7, mitochondrial 30S ribosomal protein S7 homolog bMRP-27a mitochondrial small ribosomal subunit protein uS7m
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 17 Map Location: 17q25.1
Summary	Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein. In the prokaryotic ribosome, the comparable protein is thought to play an essential role in organizing the 3' domain of the 16 S rRNA in the vicinity of the P- and A-sites. Pseudogenes corresponding to this gene are found on chromosomes 8p and 12p. [provided by RefSeq, Jul 2008].
Disorder MIM:	611974

mRNA and Protein(s)

mRNA	Protein	Name
NM_015971.3	NP_057055.2	28S ribosomal protein S7, mitochondrial
NM_015971.4	NP_057055.2	28S ribosomal protein S7, mitochondrial

Pathways from BioSystems

Homologies

	MRPS7	XP_001095210.1
Canis lupus familiaris (dog)	MRPS7	XP_852008.1
Caenorhabditis elegans (roundworm)	mrps-7	NP_502782.2
Mus musculus (house mouse)	Mrps7	NP_079581.1
Oryza sativa (rice)	Os04g0237800	NP_001173809.1
Oryza sativa (rice)	rps7	NP_039433.1
Homo sapiens (human)	MRPS7	NP_057055.2
Rattus norvegicus (Norway rat)	Mrps7	NP_001093941.1
Danio rerio (zebrafish)	mrps7	NP_001028768.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP009613	XP_318643.3
Arabidopsis thaliana (thale cress)	rps7	NP_051104.1
Pan troglodytes (chimpanzee)	MRPS7	XP_523718.1
Drosophila melanogaster (fruit fly)	mRpS7	NP_001260339.1
Xenopus tropicalis (tropical clawed frog)	mrps7	NP_001107402.1
Bos taurus (cattle)	MRPS7	NP_001029515.1
Gallus gallus (chicken)	MRPS7	NP_001026280.2
Arabidopsis thaliana (thale cress)	rps7	NP_051118.1
Oryza sativa (rice)	rps7	NP_039458.1

Gene Ontology
Bibliography

Related articles in PubMed

Mutation in mitochondrial ribosomal protein S7 (MRPS7) causes congenital sensorineural deafness, progressive hepatic and renal failure and lactic acidemia.
Menezes MJ, Guo Y, Zhang J, Riley LG, Cooper ST, Thorburn DR, Li J, Dong D, Li Z, Glessner J, Davis RL, Sue CM, Alexander SI, Arbuckle S, Kirwan P, Keating BJ, Xu X, Hakonarson H, Christodoulou J
Human molecular genetics24(8)2297-307(2015 Apr)

Ribosome. The structure of the human mitochondrial ribosome.
Amunts A, Brown A, Toots J, Scheres SHW, Ramakrishnan V
Science (New York, N.Y.)348(6230)95-98(2015 Apr)

Insights into RNA biology from an atlas of mammalian mRNA-binding proteins.
Castello A, Fischer B, Eichelbaum K, Horos R, Beckmann BM, Strein C, Davey NE, Humphreys DT, Preiss T, Steinmetz LM, Krijgsveld J, Hentze MW
Cell149(6)1393-406(2012 Jun)

The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.
Baltz AG, Munschauer M, Schwanh?usser B, Vasile A, Murakawa Y, Schueler M, Youngs N, Penfold-Brown D, Drew K, Milek M, Wyler E, Bonneau R, Selbach M, Dieterich C, Landthaler M
Molecular cell46(5)674-90(2012 Jun)

Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
Hendrickson SL, Lautenberger JA, Chinn LW, Malasky M, Sezgin E, Kingsley LA, Goedert JJ, Kirk GD, Gomperts ED, Buchbinder SP, Troyer JL, O'Brien SJ
PloS one5(9)e12862(2010 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Study identified MRPS7 mutation as a novel cause of congenital sensorineural deafness and progressive hepatic and renal failure.
Title: Mutation in mitochondrial ribosomal protein S7 (MRPS7) causes congenital sensorineural deafness, progressive hepatic and renal failure and lactic acidemia.

Observational study of gene-disease association. (HuGE Navigator)
Title: Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.

The following MRPS7 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MRPS7 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu31660	NM_015971.4 Latest version!	Homo sapiens mitochondrial ribosomal protein S7 (MRPS7), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
View Old Accession Versions >>
OHu31660	NM_015971.3	Homo sapiens mitochondrial ribosomal protein S7 (MRPS7), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

MRPS7 ( NM_015971.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_057055.2 Homo sapiens mitochondrial ribosomal protein S7 (MRPS7), mRNA.

Price & Availability↑

CloneID	OHu31660
Clone ID Related Accession (Same CDS sequence)	NM_015971.3 , NM_015971.4
Accession Version	NM_015971.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 729bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-26
Organism	Homo sapiens(human)
Product	28S ribosomal protein S7, mitochondrial
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BP379038.1, BU599633.1, BC000241.1, BG034193.1 and BU684092.1. On Apr 29, 2008 this sequence version replaced NM_015971.2. ##Evidence-Data-START## Transcript exon combination :: SRR1163658.532273.1, ERR279854.3763.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCTGCCC CCGCAGTGAA GGTTGCCCGA GGATGGTCGG GCCTGGCGTT GGGCGTGCGG 
CGGGCTGTCT TGCAGCTTCC AGGGCTAACT CAGGTGAGAT GGAGCCGCTA TAGTCCTGAA 
TTCAAGGATC CCTTGATTGA CAAGGAATAT TATCGCAAGC CAGTGGAGGA GCTAACTGAG 
GAGGAGAAAT ATGTTCGGGA GCTCAAGAAG ACTCAGCTCA TCAAAGCTGC TCCAGCAGGG 
AAAACAAGTT CTGTGTTTGA AGACCCAGTC ATCAGTAAAT TCACCAACAT GATGATGATA 
GGAGGAAACA AAGTACTGGC CAGATCCCTC ATGATTCAGA CTCTGGAAGC TGTGAAAAGG 
AAGCAGTTTG AGAAGTACCA TGCCGCTTCT GCAGAGGAAC AGGCAACCAT CGAACGCAAC 
CCCTACACCA TCTTCCATCA AGCACTGAAA AACTGTGAGC CTATGATTGG GCTGGTACCC 
ATCCTCAAGG GAGGCCGTTT CTACCAGGTC CCTGTACCCC TACCCGACCG GCGTCGCCGC 
TTCCTAGCCA TGAAGTGGAT GATCACTGAG TGCCGGGATA AAAAGCACCA GCGGACACTG 
ATGCCGGAGA AGCTGTCACA CAAGCTGCTG GAGGCTTTCC ATAACCAGGG CCCCGTGATC 
AAGAGGAAGC ATGACTTGCA CAAGATGGCA GAGGCCAACC GTGCCCTGGC CCACTACCGC 
TGGTGGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_057055.2
CDS	234..962
Translation	MAAPAVKVARGWSGLALGVRRAVLQLPGLTQVRWSRYSPEFKDPLIDKEYYRKPVEELTEEEKYVRELKKTQLIKAAPAGKTSSVFEDPVISKFTNMMMIGGNKVLARSLMIQTLEAVKRKQFEKYHAASAEEQATIERNPYTIFHQALKNCEPMIGLVPILKGGRFYQVPVPLPDRRRRFLAMKWMITECRDKKHQRTLMPEKLSHKLLEAFHNQGPVIKRKHDLHKMAEANRALAHYRWW

Target ORF information:

RefSeq Version	NM_015971.3
Organism	Homo sapiens(human)
Definition	Homo sapiens mitochondrial ribosomal protein S7 (MRPS7), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_015971.3

ORF Insert Sequence:

ATGGCTGCCC CCGCAGTGAA GGTTGCCCGA GGATGGTCGG GCCTGGCGTT GGGCGTGCGG 
CGGGCTGTCT TGCAGCTTCC AGGGCTAACT CAGGTGAGAT GGAGCCGCTA TAGTCCTGAA 
TTCAAGGATC CCTTGATTGA CAAGGAATAT TATCGCAAGC CAGTGGAGGA GCTAACTGAG 
GAGGAGAAAT ATGTTCGGGA GCTCAAGAAG ACTCAGCTCA TCAAAGCTGC TCCAGCAGGG 
AAAACAAGTT CTGTGTTTGA AGACCCAGTC ATCAGTAAAT TCACCAACAT GATGATGATA 
GGAGGAAACA AAGTACTGGC CAGATCCCTC ATGATTCAGA CTCTGGAAGC TGTGAAAAGG 
AAGCAGTTTG AGAAGTACCA TGCCGCTTCT GCAGAGGAAC AGGCAACCAT CGAACGCAAC 
CCCTACACCA TCTTCCATCA AGCACTGAAA AACTGTGAGC CTATGATTGG GCTGGTACCC 
ATCCTCAAGG GAGGCCGTTT CTACCAGGTC CCTGTACCCC TACCCGACCG GCGTCGCCGC 
TTCCTAGCCA TGAAGTGGAT GATCACTGAG TGCCGGGATA AAAAGCACCA GCGGACACTG 
ATGCCGGAGA AGCTGTCACA CAAGCTGCTG GAGGCTTTCC ATAACCAGGG CCCCGTGATC 
AAGAGGAAGC ATGACTTGCA CAAGATGGCA GAGGCCAACC GTGCCCTGGC CCACTACCGC 
TGGTGGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MRPS7 ( NM_015971.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_057055.2 Homo sapiens mitochondrial ribosomal protein S7 (MRPS7), mRNA.

Price & Availability↑

CloneID	OHu31660
Clone ID Related Accession (Same CDS sequence)	NM_015971.3 , NM_015971.4
Accession Version	NM_015971.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 729bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-26
Organism	Homo sapiens(human)
Product	28S ribosomal protein S7, mitochondrial
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC022211.5. On Nov 23, 2018 this sequence version replaced NM_015971.3. ##Evidence-Data-START## Transcript exon combination :: SRR5189667.166676.1, SRR5189667.197372.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta MANE Ensembl match :: ENST00000245539.11/ ENSP00000245539.6 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCTGCCC CCGCAGTGAA GGTTGCCCGA GGATGGTCGG GCCTGGCGTT GGGCGTGCGG 
CGGGCTGTCT TGCAGCTTCC AGGGCTAACT CAGGTGAGAT GGAGCCGCTA TAGTCCTGAA 
TTCAAGGATC CCTTGATTGA CAAGGAATAT TATCGCAAGC CAGTGGAGGA GCTAACTGAG 
GAGGAGAAAT ATGTTCGGGA GCTCAAGAAG ACTCAGCTCA TCAAAGCTGC TCCAGCAGGG 
AAAACAAGTT CTGTGTTTGA AGACCCAGTC ATCAGTAAAT TCACCAACAT GATGATGATA 
GGAGGAAACA AAGTACTGGC CAGATCCCTC ATGATTCAGA CTCTGGAAGC TGTGAAAAGG 
AAGCAGTTTG AGAAGTACCA TGCCGCTTCT GCAGAGGAAC AGGCAACCAT CGAACGCAAC 
CCCTACACCA TCTTCCATCA AGCACTGAAA AACTGTGAGC CTATGATTGG GCTGGTACCC 
ATCCTCAAGG GAGGCCGTTT CTACCAGGTC CCTGTACCCC TACCCGACCG GCGTCGCCGC 
TTCCTAGCCA TGAAGTGGAT GATCACTGAG TGCCGGGATA AAAAGCACCA GCGGACACTG 
ATGCCGGAGA AGCTGTCACA CAAGCTGCTG GAGGCTTTCC ATAACCAGGG CCCCGTGATC 
AAGAGGAAGC ATGACTTGCA CAAGATGGCA GAGGCCAACC GTGCCCTGGC CCACTACCGC 
TGGTGGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_057055.2
CDS	23..751
Translation	MAAPAVKVARGWSGLALGVRRAVLQLPGLTQVRWSRYSPEFKDPLIDKEYYRKPVEELTEEEKYVRELKKTQLIKAAPAGKTSSVFEDPVISKFTNMMMIGGNKVLARSLMIQTLEAVKRKQFEKYHAASAEEQATIERNPYTIFHQALKNCEPMIGLVPILKGGRFYQVPVPLPDRRRRFLAMKWMITECRDKKHQRTLMPEKLSHKLLEAFHNQGPVIKRKHDLHKMAEANRALAHYRWW

Target ORF information:

RefSeq Version	NM_015971.4
Organism	Homo sapiens(human)
Definition	Homo sapiens mitochondrial ribosomal protein S7 (MRPS7), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_015971.4

ORF Insert Sequence:

ATGGCTGCCC CCGCAGTGAA GGTTGCCCGA GGATGGTCGG GCCTGGCGTT GGGCGTGCGG 
CGGGCTGTCT TGCAGCTTCC AGGGCTAACT CAGGTGAGAT GGAGCCGCTA TAGTCCTGAA 
TTCAAGGATC CCTTGATTGA CAAGGAATAT TATCGCAAGC CAGTGGAGGA GCTAACTGAG 
GAGGAGAAAT ATGTTCGGGA GCTCAAGAAG ACTCAGCTCA TCAAAGCTGC TCCAGCAGGG 
AAAACAAGTT CTGTGTTTGA AGACCCAGTC ATCAGTAAAT TCACCAACAT GATGATGATA 
GGAGGAAACA AAGTACTGGC CAGATCCCTC ATGATTCAGA CTCTGGAAGC TGTGAAAAGG 
AAGCAGTTTG AGAAGTACCA TGCCGCTTCT GCAGAGGAAC AGGCAACCAT CGAACGCAAC 
CCCTACACCA TCTTCCATCA AGCACTGAAA AACTGTGAGC CTATGATTGG GCTGGTACCC 
ATCCTCAAGG GAGGCCGTTT CTACCAGGTC CCTGTACCCC TACCCGACCG GCGTCGCCGC 
TTCCTAGCCA TGAAGTGGAT GATCACTGAG TGCCGGGATA AAAAGCACCA GCGGACACTG 
ATGCCGGAGA AGCTGTCACA CAAGCTGCTG GAGGCTTTCC ATAACCAGGG CCCCGTGATC 
AAGAGGAAGC ATGACTTGCA CAAGATGGCA GAGGCCAACC GTGCCCTGGC CCACTACCGC 
TGGTGGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Mutation in mitochondrial ribosomal protein S7 (MRPS7) causes congenital sensorineural deafness, progressive hepatic and renal failure and lactic acidemia.
Human molecular genetics24(8)2297-307(2015 Apr)
Menezes MJ,Guo Y,Zhang J,Riley LG,Cooper ST,Thorburn DR,Li J,Dong D,Li Z,Glessner J,Davis RL,Sue CM,Alexander SI,Arbuckle S,Kirwan P,Keating BJ,Xu X,Hakonarson H,Christodoulou J

Ribosome. The structure of the human mitochondrial ribosome.
Science (New York, N.Y.)348(6230)95-98(2015 Apr)
Amunts A,Brown A,Toots J,Scheres SHW,Ramakrishnan V

Insights into RNA biology from an atlas of mammalian mRNA-binding proteins.
Cell149(6)1393-406(2012 Jun)
Castello A,Fischer B,Eichelbaum K,Horos R,Beckmann BM,Strein C,Davey NE,Humphreys DT,Preiss T,Steinmetz LM,Krijgsveld J,Hentze MW

The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.
Molecular cell46(5)674-90(2012 Jun)
Baltz AG,Munschauer M,Schwanh?usser B,Vasile A,Murakawa Y,Schueler M,Youngs N,Penfold-Brown D,Drew K,Milek M,Wyler E,Bonneau R,Selbach M,Dieterich C,Landthaler M

Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
PloS one5(9)e12862(2010 Sep)
Hendrickson SL,Lautenberger JA,Chinn LW,Malasky M,Sezgin E,Kingsley LA,Goedert JJ,Kirk GD,Gomperts ED,Buchbinder SP,Troyer JL,O'Brien SJ

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MRPS7 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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