FIS1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	FIS1
Entrez Gene ID	51024
Full Name	fission, mitochondrial 1
Synonyms	CGI-135,TTC11
General protein information	Preferred Names fission, mitochondrial 1 Names mitochondrial fission 1 protein FIS1 homolog H_NH0132A01.6 TPR repeat protein 11 fission 1 (mitochondrial outer membrane) homolog hFis1 mitochondrial fission molecule tetratricopeptide repeat domain 11 tetratricopeptide repeat protein 11
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 7 Map Location: 7q22.1
Summary	The balance between fission and fusion regulates the morphology of mitochondria. TTC11 is a component of a mitochondrial complex that promotes mitochondrial fission (James et al., 2003 [PubMed 12783892]).[supplied by OMIM, Mar 2008].
Disorder MIM:	609003

mRNA and Protein(s)

mRNA	Protein	Name
NM_016068.2	NP_057152.2	mitochondrial fission 1 protein
NM_016068.3	NP_057152.2	mitochondrial fission 1 protein

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	FIS1	XP_001143081.2
Bos taurus (cattle)	FIS1	NP_001029956.1
Danio rerio (zebrafish)	im:6905231	XP_005172294.1
Caenorhabditis elegans (roundworm)	fis-2	NP_001024560.1
Xenopus tropicalis (tropical clawed frog)	fis1	NP_001123678.1
Canis lupus familiaris (dog)	FIS1	XP_536854.1
Homo sapiens (human)	FIS1	NP_057152.2
	FIS1	XP_001108062.1
Mus musculus (house mouse)	Fis1	NP_079838.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP009852	XP_318964.4
Drosophila melanogaster (fruit fly)	Fis1	NP_001137607.1
Rattus norvegicus (Norway rat)	Fis1	NP_001099389.1

Gene Ontology
Bibliography

Related articles in PubMed

Inhibition of Drp1/Fis1 interaction slows progression of amyotrophic lateral sclerosis.
Joshi AU, Saw NL, Vogel H, Cunnigham AD, Shamloo M, Mochly-Rosen D
EMBO molecular medicine(2018 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Fis1 depletion in osteoarthritis impairs chondrocyte survival and peroxisomal and lysosomal function.
Title: Fis1 depletion in osteoarthritis impairs chondrocyte survival and peroxisomal and lysosomal function.

Study revealed that a novel mitochondrial fission pathway composed of miR-483-5p and FIS1 regulates cisplatin sensitivity.
Title: miR-483-5p determines mitochondrial fission and cisplatin sensitivity in tongue squamous cell carcinoma by targeting FIS1.

Results show that Fis1 is significantly overexpressed in malignant oncocytomas.
Title: Mitochondrial dynamics protein Drp1 is overexpressed in oncocytic thyroid tumors and regulates cancer cell migration.

PDCD7, Ang2 and FIS1 may indicate a more aggressive form and poor prognosis of acute myeloid leukemia.
Title: Identification of novel molecular markers for prognosis estimation of acute myeloid leukemia: over-expression of PDCD7, FIS1 and Ang2 may indicate poor prognosis in pretreatment patients with acute myeloid leukemia.

MiD49 and MiD51 can act independently of Mff and Fis1 in Drp1 recruitment and suggest that they provide specificity to the division of mitochondria.
Title: Adaptor proteins MiD49 and MiD51 can act independently of Mff and Fis1 in Drp1 recruitment and are specific for mitochondrial fission.

The following FIS1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the FIS1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu13455	NM_016068.3 Latest version!	Homo sapiens fission, mitochondrial 1 (FIS1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu13455	NM_016068.2	Homo sapiens fission, mitochondrial 1 (FIS1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

FIS1 ( NM_016068.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_057152.2 Homo sapiens fission, mitochondrial 1 (FIS1), mRNA.

Price & Availability↑

CloneID	OHu13455
Clone ID Related Accession (Same CDS sequence)	NM_016068.2 , NM_016068.3
Accession Version	NM_016068.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 459bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-03-03
Organism	Homo sapiens(human)
Product	mitochondrial fission 1 protein
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BI836529.1 and BC009428.1. On Jul 5, 2007 this sequence version replaced NM_016068.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163657.327564.1, SRR1163658.375414.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN03465403 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGAGGCCG TGCTGAACGA GCTGGTGTCT GTGGAGGACC TGCTGAAGTT TGAAAAGAAA 
TTTCAGTCTG AGAAGGCAGC AGGCTCGGTG TCCAAGAGCA CGCAGTTTGA GTACGCCTGG 
TGCCTGGTGC GGAGCAAGTA CAATGATGAC ATCCGTAAAG GCATCGTGCT GCTCGAGGAG 
CTGCTGCCCA AAGGGAGCAA GGAGGAACAG CGGGATTACG TCTTCTACCT GGCCGTGGGG 
AACTACCGGC TCAAGGAATA CGAGAAGGCC TTAAAGTACG TCCGCGGGTT GCTGCAGACA 
GAGCCCCAGA ACAACCAGGC CAAGGAACTG GAGCGGCTCA TTGACAAGGC CATGAAGAAA 
GATGGACTCG TGGGCATGGC CATCGTGGGA GGCATGGCCC TGGGTGTGGC GGGACTGGCC 
GGACTCATCG GACTTGCTGT GTCCAAGTCC AAATCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_057152.2
CDS	87..545
Translation	MEAVLNELVSVEDLLKFEKKFQSEKAAGSVSKSTQFEYAWCLVRSKYNDDIRKGIVLLEELLPKGSKEEQRDYVFYLAVGNYRLKEYEKALKYVRGLLQTEPQNNQAKELERLIDKAMKKDGLVGMAIVGGMALGVAGLAGLIGLAVSKSKS

Target ORF information:

RefSeq Version	NM_016068.2
Organism	Homo sapiens(human)
Definition	Homo sapiens fission, mitochondrial 1 (FIS1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_016068.2

ORF Insert Sequence:

ATGGAGGCCG TGCTGAACGA GCTGGTGTCT GTGGAGGACC TGCTGAAGTT TGAAAAGAAA 
TTTCAGTCTG AGAAGGCAGC AGGCTCGGTG TCCAAGAGCA CGCAGTTTGA GTACGCCTGG 
TGCCTGGTGC GGAGCAAGTA CAATGATGAC ATCCGTAAAG GCATCGTGCT GCTCGAGGAG 
CTGCTGCCCA AAGGGAGCAA GGAGGAACAG CGGGATTACG TCTTCTACCT GGCCGTGGGG 
AACTACCGGC TCAAGGAATA CGAGAAGGCC TTAAAGTACG TCCGCGGGTT GCTGCAGACA 
GAGCCCCAGA ACAACCAGGC CAAGGAACTG GAGCGGCTCA TTGACAAGGC CATGAAGAAA 
GATGGACTCG TGGGCATGGC CATCGTGGGA GGCATGGCCC TGGGTGTGGC GGGACTGGCC 
GGACTCATCG GACTTGCTGT GTCCAAGTCC AAATCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

FIS1 ( NM_016068.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_057152.2 Homo sapiens fission, mitochondrial 1 (FIS1), mRNA.

Price & Availability↑

CloneID	OHu13455
Clone ID Related Accession (Same CDS sequence)	NM_016068.2 , NM_016068.3
Accession Version	NM_016068.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 459bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-07
Organism	Homo sapiens(human)
Product	mitochondrial fission 1 protein
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BI836529.1, BC009428.1 and AC006329.5. On May 17, 2019 this sequence version replaced NM_016068.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163655.347142.1, SRR1163655.172599.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN03465403 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta MANE Ensembl match :: ENST00000223136.5/ ENSP00000223136.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGAGGCCG TGCTGAACGA GCTGGTGTCT GTGGAGGACC TGCTGAAGTT TGAAAAGAAA 
TTTCAGTCTG AGAAGGCAGC AGGCTCGGTG TCCAAGAGCA CGCAGTTTGA GTACGCCTGG 
TGCCTGGTGC GGAGCAAGTA CAATGATGAC ATCCGTAAAG GCATCGTGCT GCTCGAGGAG 
CTGCTGCCCA AAGGGAGCAA GGAGGAACAG CGGGATTACG TCTTCTACCT GGCCGTGGGG 
AACTACCGGC TCAAGGAATA CGAGAAGGCC TTAAAGTACG TCCGCGGGTT GCTGCAGACA 
GAGCCCCAGA ACAACCAGGC CAAGGAACTG GAGCGGCTCA TTGACAAGGC CATGAAGAAA 
GATGGACTCG TGGGCATGGC CATCGTGGGA GGCATGGCCC TGGGTGTGGC GGGACTGGCC 
GGACTCATCG GACTTGCTGT GTCCAAGTCC AAATCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_057152.2
CDS	78..536
Translation	MEAVLNELVSVEDLLKFEKKFQSEKAAGSVSKSTQFEYAWCLVRSKYNDDIRKGIVLLEELLPKGSKEEQRDYVFYLAVGNYRLKEYEKALKYVRGLLQTEPQNNQAKELERLIDKAMKKDGLVGMAIVGGMALGVAGLAGLIGLAVSKSKS

Target ORF information:

RefSeq Version	NM_016068.3
Organism	Homo sapiens(human)
Definition	Homo sapiens fission, mitochondrial 1 (FIS1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_016068.3

ORF Insert Sequence:

ATGGAGGCCG TGCTGAACGA GCTGGTGTCT GTGGAGGACC TGCTGAAGTT TGAAAAGAAA 
TTTCAGTCTG AGAAGGCAGC AGGCTCGGTG TCCAAGAGCA CGCAGTTTGA GTACGCCTGG 
TGCCTGGTGC GGAGCAAGTA CAATGATGAC ATCCGTAAAG GCATCGTGCT GCTCGAGGAG 
CTGCTGCCCA AAGGGAGCAA GGAGGAACAG CGGGATTACG TCTTCTACCT GGCCGTGGGG 
AACTACCGGC TCAAGGAATA CGAGAAGGCC TTAAAGTACG TCCGCGGGTT GCTGCAGACA 
GAGCCCCAGA ACAACCAGGC CAAGGAACTG GAGCGGCTCA TTGACAAGGC CATGAAGAAA 
GATGGACTCG TGGGCATGGC CATCGTGGGA GGCATGGCCC TGGGTGTGGC GGGACTGGCC 
GGACTCATCG GACTTGCTGT GTCCAAGTCC AAATCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Inhibition of Drp1/Fis1 interaction slows progression of amyotrophic lateral sclerosis.
EMBO molecular medicine(2018 Jan)
Joshi AU,Saw NL,Vogel H,Cunnigham AD,Shamloo M,Mochly-Rosen D

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FIS1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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