MRPS18C cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	MRPS18C
Entrez Gene ID	51023
Full Name	mitochondrial ribosomal protein S18C
Synonyms	CGI-134,MRP-S18-1,MRP-S18-c,MRPS18-1,S18mt-c,mrps18-c
General protein information	Preferred Names mitochondrial ribosomal protein S18C Names 28S ribosomal protein S18c, mitochondrial 28S ribosomal protein S18-1, mitochondrial mitochondrial ribosomal protein S18-1 mitochondrial small ribosomal subunit protein bS18c mitochondrial small ribosomal subunit protein bS18m mitochondrial small ribosomal subunit protein bS18m-C
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 4 Map Location: 4q21.23
Summary	Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S18P family. The encoded protein is one of three that has significant sequence similarity to bacterial S18 proteins. The primary sequences of the three human mitochondrial S18 proteins are no more closely related to each other than they are to the prokaryotic S18 proteins. Pseudogenes corresponding to this gene are found on chromosomes 8p, 12p, 15q, and 22q. [provided by RefSeq, Jul 2008].
Disorder MIM:	611983

mRNA and Protein(s)

mRNA	Protein	Name
NM_016067.3	NP_057151.1	28S ribosomal protein S18c, mitochondrial isoform 1
NM_001297770.1	NP_001284699.1	28S ribosomal protein S18c, mitochondrial isoform 4
NM_001297767.1	NP_001284696.1	28S ribosomal protein S18c, mitochondrial isoform 2
NM_001297769.1	NP_001284698.1	28S ribosomal protein S18c, mitochondrial isoform 3
NM_016067.4	NP_057151.1	28S ribosomal protein S18c, mitochondrial isoform 1

Pathways from BioSystems

Homologies

Homo sapiens (human)	MRPS18C	NP_057151.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP008773	XP_314899.3
Pan troglodytes (chimpanzee)	MRPS18C	XP_517249.1
Mus musculus (house mouse)	Mrps18c	NP_081102.1
Caenorhabditis elegans (roundworm)	T14B4.2	NP_495374.1
Bos taurus (cattle)	MRPS18C	NP_001039973.1
Canis lupus familiaris (dog)	MRPS18C	XP_535635.1
Rattus norvegicus (Norway rat)	Mrps18c	NP_001099466.1
Gallus gallus (chicken)	MRPS18C	NP_001239240.1
Danio rerio (zebrafish)	mrps18c	NP_001038655.2
Drosophila melanogaster (fruit fly)	mRpS18C	NP_524593.1
	MRPS18C	XP_001104605.1
Xenopus tropicalis (tropical clawed frog)	mrps18c	NP_001017092.2

Gene Ontology
Bibliography

Related articles in PubMed

An innovative strategy to clone positive modifier genes of defects caused by mtDNA mutations: MRPS18C as suppressor gene of m.3946G>A mutation in MT-ND1 gene.
Rodr?guez-Garc?a ME, Cotrina-Vinagre FJ, Carnicero-Rodr?guez P, Mart?nez-Azor?n F
Human genetics136(7)885-896(2017 Jul)

Ribosome. The structure of the human mitochondrial ribosome.
Amunts A, Brown A, Toots J, Scheres SHW, Ramakrishnan V
Science (New York, N.Y.)348(6230)95-98(2015 Apr)

Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
Hendrickson SL, Lautenberger JA, Chinn LW, Malasky M, Sezgin E, Kingsley LA, Goedert JJ, Kirk GD, Gomperts ED, Buchbinder SP, Troyer JL, O'Brien SJ
PloS one5(9)e12862(2010 Sep)

Identification and characterization of over 100 mitochondrial ribosomal protein pseudogenes in the human genome.
Zhang Z, Gerstein M
Genomics81(5)468-80(2003 May)

The small subunit of the mammalian mitochondrial ribosome. Identification of the full complement of ribosomal proteins present.
Cavdar Koc E, Burkhart W, Blackburn K, Moseley A, Spremulli LL
The Journal of biological chemistry276(22)19363-74(2001 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Overexpression of MRPS18C gene (that encode for bS18m protein) suppressed the molecular defects produced by this mtDNA mutation, recovering the complex I activity and reducing the reactive oxygen species produced by this complex to normal levels.
Title: An innovative strategy to clone positive modifier genes of defects caused by mtDNA mutations: MRPS18C as suppressor gene of m.3946G>A mutation in MT-ND1 gene.

Observational study of gene-disease association. (HuGE Navigator)
Title: Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.

Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.

The following MRPS18C gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MRPS18C cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu31893	NM_016067.4 Latest version!	Homo sapiens mitochondrial ribosomal protein S18C (MRPS18C), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu38956	NM_001297767.1 Latest version!	Homo sapiens mitochondrial ribosomal protein S18C (MRPS18C), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OHu67586	NM_001297769.1 Latest version!	Homo sapiens mitochondrial ribosomal protein S18C (MRPS18C), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OHu67587	NM_001297770.1 Latest version!	Homo sapiens mitochondrial ribosomal protein S18C (MRPS18C), transcript variant 4, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
View Old Accession Versions >>
OHu31893	NM_016067.3	Homo sapiens mitochondrial ribosomal protein S18C (MRPS18C), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

MRPS18C ( NM_016067.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_057151.1 Homo sapiens mitochondrial ribosomal protein S18C (MRPS18C), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu31893
Clone ID Related Accession (Same CDS sequence)	NM_016067.3 , NM_016067.4
Accession Version	NM_016067.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 429bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-02
Organism	Homo sapiens(human)
Product	28S ribosomal protein S18c, mitochondrial isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA446717.1, AF151892.1 and AC096768.3. On Jul 10, 2014 this sequence version replaced NM_016067.2. Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). ##Evidence-Data-START## Transcript exon combination :: AF151892.1, SRR1803614.254859.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCCGCTG TGGTTGCTGT TTGCGGTGGT CTAGGGAGGA AGAAGTTGAC ACACTTGGTA 
ACGGCTGCTG TCAGCCTTAC ACATCCCGGG ACTCACACGG TGCTTTGGAG AAGAGGTTGT 
TCACAACAGG TATCCAGCAA TGAGGACCTG CCCATTTCAA TGGAAAATCC TTATAAAGAA 
CCTCTTAAGA AATGTATCTT GTGTGGAAAG CATGTAGATT ATAAGAATGT ACAGCTTTTG 
TCCCAGTTTG TTTCTCCATT TACTGGATGC ATTTATGGAA GGCACATTAC AGGTCTTTGT 
GGGAAGAAAC AGAAAGAAAT CACAAAAGCA ATTAAGAGAG CTCAAATAAT GGGGTTTATG 
CCAGTTACAT ACAAGGATCC TGCATATCTC AAGGACCCTA AAGTTTGTAA CATCAGATAT 
CGGGAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_057151.1
CDS	147..575
Translation	MAAVVAVCGGLGRKKLTHLVTAAVSLTHPGTHTVLWRRGCSQQVSSNEDLPISMENPYKEPLKKCILCGKHVDYKNVQLLSQFVSPFTGCIYGRHITGLCGKKQKEITKAIKRAQIMGFMPVTYKDPAYLKDPKVCNIRYRE

Target ORF information:

RefSeq Version	NM_016067.3
Organism	Homo sapiens(human)
Definition	Homo sapiens mitochondrial ribosomal protein S18C (MRPS18C), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_016067.3

ORF Insert Sequence:

ATGGCCGCTG TGGTTGCTGT TTGCGGTGGT CTAGGGAGGA AGAAGTTGAC ACACTTGGTA 
ACGGCTGCTG TCAGCCTTAC ACATCCCGGG ACTCACACGG TGCTTTGGAG AAGAGGTTGT 
TCACAACAGG TATCCAGCAA TGAGGACCTG CCCATTTCAA TGGAAAATCC TTATAAAGAA 
CCTCTTAAGA AATGTATCTT GTGTGGAAAG CATGTAGATT ATAAGAATGT ACAGCTTTTG 
TCCCAGTTTG TTTCTCCATT TACTGGATGC ATTTATGGAA GGCACATTAC AGGTCTTTGT 
GGGAAGAAAC AGAAAGAAAT CACAAAAGCA ATTAAGAGAG CTCAAATAAT GGGGTTTATG 
CCAGTTACAT ACAAGGATCC TGCATATCTC AAGGACCCTA AAGTTTGTAA CATCAGATAT 
CGGGAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MRPS18C ( NM_016067.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_057151.1 Homo sapiens mitochondrial ribosomal protein S18C (MRPS18C), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu31893
Clone ID Related Accession (Same CDS sequence)	NM_016067.3 , NM_016067.4
Accession Version	NM_016067.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 429bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-23
Organism	Homo sapiens(human)
Product	28S ribosomal protein S18c, mitochondrial isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF151892.1 and AC096768.3. On Nov 22, 2018 this sequence version replaced NM_016067.3. Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). ##Evidence-Data-START## Transcript exon combination :: SRR3476690.16371.1, SRR1803611.183453.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta MANE Ensembl match :: ENST00000295491.9/ ENSP00000295491.4 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCCGCTG TGGTTGCTGT TTGCGGTGGT CTAGGGAGGA AGAAGTTGAC ACACTTGGTA 
ACGGCTGCTG TCAGCCTTAC ACATCCCGGG ACTCACACGG TGCTTTGGAG AAGAGGTTGT 
TCACAACAGG TATCCAGCAA TGAGGACCTG CCCATTTCAA TGGAAAATCC TTATAAAGAA 
CCTCTTAAGA AATGTATCTT GTGTGGAAAG CATGTAGATT ATAAGAATGT ACAGCTTTTG 
TCCCAGTTTG TTTCTCCATT TACTGGATGC ATTTATGGAA GGCACATTAC AGGTCTTTGT 
GGGAAGAAAC AGAAAGAAAT CACAAAAGCA ATTAAGAGAG CTCAAATAAT GGGGTTTATG 
CCAGTTACAT ACAAGGATCC TGCATATCTC AAGGACCCTA AAGTTTGTAA CATCAGATAT 
CGGGAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_057151.1
CDS	21..449
Translation	MAAVVAVCGGLGRKKLTHLVTAAVSLTHPGTHTVLWRRGCSQQVSSNEDLPISMENPYKEPLKKCILCGKHVDYKNVQLLSQFVSPFTGCIYGRHITGLCGKKQKEITKAIKRAQIMGFMPVTYKDPAYLKDPKVCNIRYRE

Target ORF information:

RefSeq Version	NM_016067.4
Organism	Homo sapiens(human)
Definition	Homo sapiens mitochondrial ribosomal protein S18C (MRPS18C), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_016067.4

ORF Insert Sequence:

ATGGCCGCTG TGGTTGCTGT TTGCGGTGGT CTAGGGAGGA AGAAGTTGAC ACACTTGGTA 
ACGGCTGCTG TCAGCCTTAC ACATCCCGGG ACTCACACGG TGCTTTGGAG AAGAGGTTGT 
TCACAACAGG TATCCAGCAA TGAGGACCTG CCCATTTCAA TGGAAAATCC TTATAAAGAA 
CCTCTTAAGA AATGTATCTT GTGTGGAAAG CATGTAGATT ATAAGAATGT ACAGCTTTTG 
TCCCAGTTTG TTTCTCCATT TACTGGATGC ATTTATGGAA GGCACATTAC AGGTCTTTGT 
GGGAAGAAAC AGAAAGAAAT CACAAAAGCA ATTAAGAGAG CTCAAATAAT GGGGTTTATG 
CCAGTTACAT ACAAGGATCC TGCATATCTC AAGGACCCTA AAGTTTGTAA CATCAGATAT 
CGGGAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MRPS18C ( NM_001297767.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001284696.1 Homo sapiens mitochondrial ribosomal protein S18C (MRPS18C), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu38956
Clone ID Related Accession (Same CDS sequence)	NM_001297767.1
Accession Version	NM_001297767.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 345bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-21
Organism	Homo sapiens(human)
Product	28S ribosomal protein S18c, mitochondrial isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA446717.1, CN262115.1 and AC096768.3. On Jul 10, 2014 this sequence version replaced XM_005263043.1. Transcript Variant: This variant (2) lacks an in-frame exon in the central coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: SRR1660809.214864.1, SRR1803611.166264.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCCGCTG TGGTTGCTGT TTGCGGTGGT CTAGGGAGGA AGAAGTTGAC ACACTTGGTA 
ACGGCTGCTG TCAGCCTTAC ACATCCCGGG ACTCACACGG TGCTTTGGAG AAGAGGTTGT 
TCACAACAGG TATCCAGCAA TGAGGACCTG CTTTTGTCCC AGTTTGTTTC TCCATTTACT 
GGATGCATTT ATGGAAGGCA CATTACAGGT CTTTGTGGGA AGAAACAGAA AGAAATCACA 
AAAGCAATTA AGAGAGCTCA AATAATGGGG TTTATGCCAG TTACATACAA GGATCCTGCA 
TATCTCAAGG ACCCTAAAGT TTGTAACATC AGATATCGGG AATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001284696.1
CDS	147..491
Translation	MAAVVAVCGGLGRKKLTHLVTAAVSLTHPGTHTVLWRRGCSQQVSSNEDLLLSQFVSPFTGCIYGRHITGLCGKKQKEITKAIKRAQIMGFMPVTYKDPAYLKDPKVCNIRYRE

Target ORF information:

RefSeq Version	NM_001297767.1
Organism	Homo sapiens(human)
Definition	Homo sapiens mitochondrial ribosomal protein S18C (MRPS18C), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001297767.1

ORF Insert Sequence:

ATGGCCGCTG TGGTTGCTGT TTGCGGTGGT CTAGGGAGGA AGAAGTTGAC ACACTTGGTA 
ACGGCTGCTG TCAGCCTTAC ACATCCCGGG ACTCACACGG TGCTTTGGAG AAGAGGTTGT 
TCACAACAGG TATCCAGCAA TGAGGACCTG CTTTTGTCCC AGTTTGTTTC TCCATTTACT 
GGATGCATTT ATGGAAGGCA CATTACAGGT CTTTGTGGGA AGAAACAGAA AGAAATCACA 
AAAGCAATTA AGAGAGCTCA AATAATGGGG TTTATGCCAG TTACATACAA GGATCCTGCA 
TATCTCAAGG ACCCTAAAGT TTGTAACATC AGATATCGGG AATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MRPS18C ( NM_001297769.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001284698.1 Homo sapiens mitochondrial ribosomal protein S18C (MRPS18C), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu67586
Clone ID Related Accession (Same CDS sequence)	NM_001297769.1
Accession Version	NM_001297769.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 291bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-21
Organism	Homo sapiens(human)
Product	28S ribosomal protein S18c, mitochondrial isoform 3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA446717.1, BE874586.1, AF151892.1 and AC096768.3. Transcript Variant: This variant (3) lacks an exon in the central coding region, which leads to a frameshift, compared to variant 1. The encoded isoform (3) has a shorter and distinct C-terminus. ##Evidence-Data-START## Transcript exon combination :: BE874586.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCCGCTG TGGTTGCTGT TTGCGGTGGT CTAGGGAGGA AGAAGTTGAC ACACTTGGTA 
ACGGCTGCTG TCAGCCTTAC ACATCCCGGG ACTCACACGG TGCTTTGGAG AAGAGGTTGT 
TCACAACAGG TATCCAGCAA TGAGGACCTG CCCATTTCAA TGGAAAATCC TTATAAAGAA 
CCTCTTAAGA AATGTATCTT GTGTGGAAAG CATGTAGATT ATAAGAATGT ACAGGTCTTT 
GTGGGAAGAA ACAGAAAGAA ATCACAAAAG CAATTAAGAG AGCTCAAATA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001284698.1
CDS	147..437
Translation	MAAVVAVCGGLGRKKLTHLVTAAVSLTHPGTHTVLWRRGCSQQVSSNEDLPISMENPYKEPLKKCILCGKHVDYKNVQVFVGRNRKKSQKQLRELK

Target ORF information:

RefSeq Version	NM_001297769.1
Organism	Homo sapiens(human)
Definition	Homo sapiens mitochondrial ribosomal protein S18C (MRPS18C), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001297769.1

ORF Insert Sequence:

ATGGCCGCTG TGGTTGCTGT TTGCGGTGGT CTAGGGAGGA AGAAGTTGAC ACACTTGGTA 
ACGGCTGCTG TCAGCCTTAC ACATCCCGGG ACTCACACGG TGCTTTGGAG AAGAGGTTGT 
TCACAACAGG TATCCAGCAA TGAGGACCTG CCCATTTCAA TGGAAAATCC TTATAAAGAA 
CCTCTTAAGA AATGTATCTT GTGTGGAAAG CATGTAGATT ATAAGAATGT ACAGGTCTTT 
GTGGGAAGAA ACAGAAAGAA ATCACAAAAG CAATTAAGAG AGCTCAAATA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MRPS18C ( NM_001297770.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001284699.1 Homo sapiens mitochondrial ribosomal protein S18C (MRPS18C), transcript variant 4, mRNA.

Price & Availability↑

CloneID	OHu67587
Clone ID Related Accession (Same CDS sequence)	NM_001297770.1
Accession Version	NM_001297770.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 207bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-21
Organism	Homo sapiens(human)
Product	28S ribosomal protein S18c, mitochondrial isoform 4
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA446717.1, CA455563.1, AF151892.1 and AC096768.3. Transcript Variant: This variant (4) lacks two consecutive exons in the central coding region, which leads to a frameshift, compared to variant 1. The encoded isoform (4) has a shorter and distinct C-terminus, compared to isoform 1. ##Evidence-Data-START## Transcript exon combination :: SRR1803615.109126.1, CA455563.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCCGCTG TGGTTGCTGT TTGCGGTGGT CTAGGGAGGA AGAAGTTGAC ACACTTGGTA 
ACGGCTGCTG TCAGCCTTAC ACATCCCGGG ACTCACACGG TGCTTTGGAG AAGAGGTTGT 
TCACAACAGG TATCCAGCAA TGAGGACCTG GTCTTTGTGG GAAGAAACAG AAAGAAATCA 
CAAAAGCAAT TAAGAGAGCT CAAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001284699.1
CDS	147..353
Translation	MAAVVAVCGGLGRKKLTHLVTAAVSLTHPGTHTVLWRRGCSQQVSSNEDLVFVGRNRKKSQKQLRELK

Target ORF information:

RefSeq Version	NM_001297770.1
Organism	Homo sapiens(human)
Definition	Homo sapiens mitochondrial ribosomal protein S18C (MRPS18C), transcript variant 4, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001297770.1

ORF Insert Sequence:

ATGGCCGCTG TGGTTGCTGT TTGCGGTGGT CTAGGGAGGA AGAAGTTGAC ACACTTGGTA 
ACGGCTGCTG TCAGCCTTAC ACATCCCGGG ACTCACACGG TGCTTTGGAG AAGAGGTTGT 
TCACAACAGG TATCCAGCAA TGAGGACCTG GTCTTTGTGG GAAGAAACAG AAAGAAATCA 
CAAAAGCAAT TAAGAGAGCT CAAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

An innovative strategy to clone positive modifier genes of defects caused by mtDNA mutations: MRPS18C as suppressor gene of m.3946G>A mutation in MT-ND1 gene.
Human genetics136(7)885-896(2017 Jul)
Rodr?guez-Garc?a ME,Cotrina-Vinagre FJ,Carnicero-Rodr?guez P,Mart?nez-Azor?n F

Ribosome. The structure of the human mitochondrial ribosome.
Science (New York, N.Y.)348(6230)95-98(2015 Apr)
Amunts A,Brown A,Toots J,Scheres SHW,Ramakrishnan V

Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
PloS one5(9)e12862(2010 Sep)
Hendrickson SL,Lautenberger JA,Chinn LW,Malasky M,Sezgin E,Kingsley LA,Goedert JJ,Kirk GD,Gomperts ED,Buchbinder SP,Troyer JL,O'Brien SJ

Identification and characterization of over 100 mitochondrial ribosomal protein pseudogenes in the human genome.
Genomics81(5)468-80(2003 May)
Zhang Z,Gerstein M

The small subunit of the mammalian mitochondrial ribosome. Identification of the full complement of ribosomal proteins present.
The Journal of biological chemistry276(22)19363-74(2001 Jun)
Cavdar Koc E,Burkhart W,Blackburn K,Moseley A,Spremulli LL

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MRPS18C cDNA ORF clone, Homo sapiens(human)

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ORF Insert Sequence:

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Target ORF information:

ORF Insert Sequence:

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Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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