EXOSC3 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	EXOSC3
Entrez Gene ID	51010
Full Name	exosome component 3
Synonyms	CGI-102,PCH1B,RRP40,Rrp40p,bA3J10.7,hRrp-40,p10
General protein information	Preferred Names exosome component 3 Names exosome complex component RRP40 exosome complex exonuclease RRP40 ribosomal RNA-processing protein 40
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 9 Map Location: 9p13.2
Summary	This gene encodes a non-catalytic component of the human exosome, a complex with 3'-5' exoribonuclease activity that plays a role in numerous RNA processing and degradation activities. Related pseudogenes of this gene are found on chromosome 19 and 21. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jun 2012].
Disorder MIM:	606489
Disorder Html:	Pontocerebellar hypoplasia, type 1B, 614678 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_016042.3	NP_057126.2	exosome complex component RRP40 isoform 1
NM_001002269.2	NP_001002269.1	exosome complex component RRP40 isoform 2
NM_016042.4	NP_057126.2	exosome complex component RRP40 isoform 1

Pathways from BioSystems

Homologies

Caenorhabditis elegans (roundworm)	exos-3	NP_492751.1
Eremothecium gossypii	AGOS_ADL196W	NP_983900.2
Schizosaccharomyces pombe (fission yeast)	SPAC22A12.12c	NP_593242.1
Bos taurus (cattle)	EXOSC3	NP_001030474.1
Rattus norvegicus (Norway rat)	Exosc3	NP_001101406.1
Saccharomyces cerevisiae (baker's yeast)	RRP40	NP_014499.2
Neurospora crassa	NCU00693	XP_965833.1
Canis lupus familiaris (dog)	EXOSC3	XP_538738.1
Mus musculus (house mouse)	Exosc3	NP_079789.1
Gallus gallus (chicken)	EXOSC3	NP_001186445.1
Danio rerio (zebrafish)	exosc3	NP_001025132.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP010247	XP_319438.3
Kluyveromyces lactis	KLLA0E02091g	XP_454042.1
	EXOSC3	XP_001114719.1
Arabidopsis thaliana (thale cress)	AT4G32175	NP_680755.2
Arabidopsis thaliana (thale cress)	AT2G25355	NP_565592.1
Oryza sativa (rice)	Os01g0661400	NP_001043778.1
Homo sapiens (human)	EXOSC3	NP_057126.2
Pan troglodytes (chimpanzee)	EXOSC3	XP_520587.2
Drosophila melanogaster (fruit fly)	Rrp40	NP_722725.1
Magnaporthe oryzae (rice blast fungus)	MGG_02843	XP_003720894.1
Xenopus tropicalis (tropical clawed frog)	LOC100491278	XP_002936379.2

Gene Ontology
Bibliography

Related articles in PubMed

Recessive mutation in EXOSC3 associates with mitochondrial dysfunction and pontocerebellar hypoplasia.
Schottmann G, Picker-Minh S, Schwarz JM, Gill E, Rodenburg RJT, Stenzel W, Kaindl AM, Schuelke M
Mitochondrion3746-54(2017 Nov)

Architecture of the human interactome defines protein communities and disease networks.
Huttlin EL, Bruckner RJ, Paulo JA, Cannon JR, Ting L, Baltier K, Colby G, Gebreab F, Gygi MP, Parzen H, Szpyt J, Tam S, Zarraga G, Pontano-Vaites L, Swarup S, White AE, Schweppe DK, Rad R, Erickson BK, Obar RA, Guruharsha KG, Li K, Artavanis-Tsakonas S, Gygi SP, Harper JW
Nature545(7655)505-509(2017 05)

Mutations of EXOSC3/Rrp40p associated with neurological diseases impact ribosomal RNA processing functions of the exosome in
Gillespie A, Gabunilas J, Jen JC, Chanfreau GF
RNA (New York, N.Y.)23(4)466-472(2017 04)

Altered RNA metabolism due to a homozygous RBM7 mutation in a patient with spinal motor neuropathy.
Giunta M, Edvardson S, Xu Y, Schuelke M, Gomez-Duran A, Boczonadi V, Elpeleg O, M?ller JS, Horvath R
Human molecular genetics25(14)2985-2996(2016 07)

A human interactome in three quantitative dimensions organized by stoichiometries and abundances.
Hein MY, Hubner NC, Poser I, Cox J, Nagaraj N, Toyoda Y, Gak IA, Weisswange I, Mansfeld J, Buchholz F, Hyman AA, Mann M
Cell163(3)712-23(2015 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Mutations of EXOSC3/Rrp40p associated with pontocerebellar hypoplasia with progressive cerebral atrophy impact ribosomal RNA processing functions of the exosome in S. cerevisiae.
Title: Mutations of EXOSC3/Rrp40p associated with neurological diseases impact ribosomal RNA processing functions of the exosome in

Knock-down of rbm7, exosc8 and exosc3 in zebrafish showed a common pattern of defects in motor neurons and cerebellum. Our data indicate that impaired RNA metabolism may underlie the clinical phenotype by fine tuning gene expression which is essential for correct neuronal differentiation
Title: Altered RNA metabolism due to a homozygous RBM7 mutation in a patient with spinal motor neuropathy.

EXOSC3 mutations were linked to complicated hereditary spastic paraplegia.
Title: Novel EXOSC3 mutation causes complicated hereditary spastic paraplegia.

study identified new nonsense and missense mutations in the EXOSC3 gene and showed mutations in this gene are exclusively found in pontocerebellar hypoplasia type 1 patients; there are evident genotype-phenotype correlations in EXOSC3-mediated PCH reflected in clinical outcome, age of death and pons hypoplasia
Title: EXOSC3 mutations in pontocerebellar hypoplasia type 1: novel mutations and genotype-phenotype correlations.

The present study indicates that EXOSC3 mutations can underlie clinical phenotype not classifiable as pontocerebellar hypoplasia type 1.
Title: Exome sequencing in a family with intellectual disability, early onset spasticity, and cerebellar atrophy detects a novel mutation in EXOSC3.

The following EXOSC3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the EXOSC3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu19823	NM_016042.4 Latest version!	Homo sapiens exosome component 3 (EXOSC3), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu09989	NM_001002269.2 Latest version!	Homo sapiens exosome component 3 (EXOSC3), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
View Old Accession Versions >>
OHu19823	NM_016042.3	Homo sapiens exosome component 3 (EXOSC3), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

EXOSC3 ( NM_016042.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_057126.2 Homo sapiens exosome component 3 (EXOSC3), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu19823
Clone ID Related Accession (Same CDS sequence)	NM_016042.3 , NM_016042.4
Accession Version	NM_016042.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 828bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-27
Organism	Homo sapiens(human)
Product	exosome complex component RRP40 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BP237222.1, AF281132.1, AK290864.1 and BE048144.1. This sequence is a reference standard in the RefSeqGene project. On Jun 2, 2012 this sequence version replaced NM_016042.2. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660803.163190.1, SRR1803614.37606.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2153932, SAMEA2467146 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCCGAAC CTGCGTCTGT CGCGGCTGAA TCTCTCGCGG GCAGCAGGGC GCGCGCTGCA 
CGCACAGTAC TAGGTCAGGT GGTGCTCCCG GGTGAGGAGC TGCTCCTGCC GGAACAGGAG 
GACGCGGAAG GCCCTGGGGG TGCAGTGGAG CGACCGTTGA GCCTGAATGC TAGAGCGTGC 
TCGCGGGTGC GCGTTGTATG CGGTCCGGGC CTTCGGCGCT GTGGGGACCG CCTGCTGGTC 
ACCAAGTGCG GCCGCCTCCG TCACAAGGAG CCCGGCAGTG GCAGCGGCGG CGGTGTTTAC 
TGGGTGGACT CTCAGCAGAA GCGGTATGTT CCAGTAAAAG GAGACCATGT GATTGGCATA 
GTGACAGCTA AATCTGGAGA TATATTCAAA GTTGATGTTG GAGGGAGTGA GCCAGCTTCT 
TTGTCTTACT TGTCATTTGA AGGTGCAACT AAAAGAAACA GACCAAATGT GCAGGTTGGA 
GATCTCATCT ATGGCCAGTT TGTGGTTGCT AATAAAGACA TGGAACCAGA GATGGTCTGT 
ATTGACAGCT GTGGACGAGC CAATGGAATG GGTGTCATTG GACAGGATGG TCTGCTTTTT 
AAAGTGACTC TGGGCTTAAT TAGAAAGCTA TTAGCTCCAG ATTGTGAAAT CATACAGGAA 
GTGGGAAAAC TCTATCCACT GGAGATAGTA TTTGGAATGA ATGGAAGAAT ATGGGTTAAG 
GCAAAAACCA TCCAGCAGAC TTTAATTTTG GCAAACATTT TAGAAGCTTG TGAACACATG 
ACGTCAGATC AAAGAAAACA GATCTTCTCC AGATTGGCAG AAAGTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_057126.2
CDS	49..876
Translation	MAEPASVAAESLAGSRARAARTVLGQVVLPGEELLLPEQEDAEGPGGAVERPLSLNARACSRVRVVCGPGLRRCGDRLLVTKCGRLRHKEPGSGSGGGVYWVDSQQKRYVPVKGDHVIGIVTAKSGDIFKVDVGGSEPASLSYLSFEGATKRNRPNVQVGDLIYGQFVVANKDMEPEMVCIDSCGRANGMGVIGQDGLLFKVTLGLIRKLLAPDCEIIQEVGKLYPLEIVFGMNGRIWVKAKTIQQTLILANILEACEHMTSDQRKQIFSRLAES

Target ORF information:

RefSeq Version	NM_016042.3
Organism	Homo sapiens(human)
Definition	Homo sapiens exosome component 3 (EXOSC3), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_016042.3

ORF Insert Sequence:

ATGGCCGAAC CTGCGTCTGT CGCGGCTGAA TCTCTCGCGG GCAGCAGGGC GCGCGCTGCA 
CGCACAGTAC TAGGTCAGGT GGTGCTCCCG GGTGAGGAGC TGCTCCTGCC GGAACAGGAG 
GACGCGGAAG GCCCTGGGGG TGCAGTGGAG CGACCGTTGA GCCTGAATGC TAGAGCGTGC 
TCGCGGGTGC GCGTTGTATG CGGTCCGGGC CTTCGGCGCT GTGGGGACCG CCTGCTGGTC 
ACCAAGTGCG GCCGCCTCCG TCACAAGGAG CCCGGCAGTG GCAGCGGCGG CGGTGTTTAC 
TGGGTGGACT CTCAGCAGAA GCGGTATGTT CCAGTAAAAG GAGACCATGT GATTGGCATA 
GTGACAGCTA AATCTGGAGA TATATTCAAA GTTGATGTTG GAGGGAGTGA GCCAGCTTCT 
TTGTCTTACT TGTCATTTGA AGGTGCAACT AAAAGAAACA GACCAAATGT GCAGGTTGGA 
GATCTCATCT ATGGCCAGTT TGTGGTTGCT AATAAAGACA TGGAACCAGA GATGGTCTGT 
ATTGACAGCT GTGGACGAGC CAATGGAATG GGTGTCATTG GACAGGATGG TCTGCTTTTT 
AAAGTGACTC TGGGCTTAAT TAGAAAGCTA TTAGCTCCAG ATTGTGAAAT CATACAGGAA 
GTGGGAAAAC TCTATCCACT GGAGATAGTA TTTGGAATGA ATGGAAGAAT ATGGGTTAAG 
GCAAAAACCA TCCAGCAGAC TTTAATTTTG GCAAACATTT TAGAAGCTTG TGAACACATG 
ACGTCAGATC AAAGAAAACA GATCTTCTCC AGATTGGCAG AAAGTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

EXOSC3 ( NM_016042.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_057126.2 Homo sapiens exosome component 3 (EXOSC3), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu19823
Clone ID Related Accession (Same CDS sequence)	NM_016042.3 , NM_016042.4
Accession Version	NM_016042.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 828bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-16
Organism	Homo sapiens(human)
Product	exosome complex component RRP40 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF281132.1, AK290864.1 and BE048144.1. This sequence is a reference standard in the RefSeqGene project. On Nov 22, 2018 this sequence version replaced NM_016042.3. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803614.56586.1, SRR1660803.163190.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2153932, SAMEA2467146 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000327304.10/ ENSP00000323046.4 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCCGAAC CTGCGTCTGT CGCGGCTGAA TCTCTCGCGG GCAGCAGGGC GCGCGCTGCA 
CGCACAGTAC TAGGTCAGGT GGTGCTCCCG GGTGAGGAGC TGCTCCTGCC GGAACAGGAG 
GACGCGGAAG GCCCTGGGGG TGCAGTGGAG CGACCGTTGA GCCTGAATGC TAGAGCGTGC 
TCGCGGGTGC GCGTTGTATG CGGTCCGGGC CTTCGGCGCT GTGGGGACCG CCTGCTGGTC 
ACCAAGTGCG GCCGCCTCCG TCACAAGGAG CCCGGCAGTG GCAGCGGCGG CGGTGTTTAC 
TGGGTGGACT CTCAGCAGAA GCGGTATGTT CCAGTAAAAG GAGACCATGT GATTGGCATA 
GTGACAGCTA AATCTGGAGA TATATTCAAA GTTGATGTTG GAGGGAGTGA GCCAGCTTCT 
TTGTCTTACT TGTCATTTGA AGGTGCAACT AAAAGAAACA GACCAAATGT GCAGGTTGGA 
GATCTCATCT ATGGCCAGTT TGTGGTTGCT AATAAAGACA TGGAACCAGA GATGGTCTGT 
ATTGACAGCT GTGGACGAGC CAATGGAATG GGTGTCATTG GACAGGATGG TCTGCTTTTT 
AAAGTGACTC TGGGCTTAAT TAGAAAGCTA TTAGCTCCAG ATTGTGAAAT CATACAGGAA 
GTGGGAAAAC TCTATCCACT GGAGATAGTA TTTGGAATGA ATGGAAGAAT ATGGGTTAAG 
GCAAAAACCA TCCAGCAGAC TTTAATTTTG GCAAACATTT TAGAAGCTTG TGAACACATG 
ACGTCAGATC AAAGAAAACA GATCTTCTCC AGATTGGCAG AAAGTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_057126.2
CDS	21..848
Translation	MAEPASVAAESLAGSRARAARTVLGQVVLPGEELLLPEQEDAEGPGGAVERPLSLNARACSRVRVVCGPGLRRCGDRLLVTKCGRLRHKEPGSGSGGGVYWVDSQQKRYVPVKGDHVIGIVTAKSGDIFKVDVGGSEPASLSYLSFEGATKRNRPNVQVGDLIYGQFVVANKDMEPEMVCIDSCGRANGMGVIGQDGLLFKVTLGLIRKLLAPDCEIIQEVGKLYPLEIVFGMNGRIWVKAKTIQQTLILANILEACEHMTSDQRKQIFSRLAES

Target ORF information:

RefSeq Version	NM_016042.4
Organism	Homo sapiens(human)
Definition	Homo sapiens exosome component 3 (EXOSC3), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_016042.4

ORF Insert Sequence:

ATGGCCGAAC CTGCGTCTGT CGCGGCTGAA TCTCTCGCGG GCAGCAGGGC GCGCGCTGCA 
CGCACAGTAC TAGGTCAGGT GGTGCTCCCG GGTGAGGAGC TGCTCCTGCC GGAACAGGAG 
GACGCGGAAG GCCCTGGGGG TGCAGTGGAG CGACCGTTGA GCCTGAATGC TAGAGCGTGC 
TCGCGGGTGC GCGTTGTATG CGGTCCGGGC CTTCGGCGCT GTGGGGACCG CCTGCTGGTC 
ACCAAGTGCG GCCGCCTCCG TCACAAGGAG CCCGGCAGTG GCAGCGGCGG CGGTGTTTAC 
TGGGTGGACT CTCAGCAGAA GCGGTATGTT CCAGTAAAAG GAGACCATGT GATTGGCATA 
GTGACAGCTA AATCTGGAGA TATATTCAAA GTTGATGTTG GAGGGAGTGA GCCAGCTTCT 
TTGTCTTACT TGTCATTTGA AGGTGCAACT AAAAGAAACA GACCAAATGT GCAGGTTGGA 
GATCTCATCT ATGGCCAGTT TGTGGTTGCT AATAAAGACA TGGAACCAGA GATGGTCTGT 
ATTGACAGCT GTGGACGAGC CAATGGAATG GGTGTCATTG GACAGGATGG TCTGCTTTTT 
AAAGTGACTC TGGGCTTAAT TAGAAAGCTA TTAGCTCCAG ATTGTGAAAT CATACAGGAA 
GTGGGAAAAC TCTATCCACT GGAGATAGTA TTTGGAATGA ATGGAAGAAT ATGGGTTAAG 
GCAAAAACCA TCCAGCAGAC TTTAATTTTG GCAAACATTT TAGAAGCTTG TGAACACATG 
ACGTCAGATC AAAGAAAACA GATCTTCTCC AGATTGGCAG AAAGTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

EXOSC3 ( NM_001002269.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001002269.1 Homo sapiens exosome component 3 (EXOSC3), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu09989
Clone ID Related Accession (Same CDS sequence)	NM_001002269.2
Accession Version	NM_001002269.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 495bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-09
Organism	Homo sapiens(human)
Product	exosome complex component RRP40 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BP237222.1, DA352003.1, AF229833.1, AK290864.1 and BE048144.1. On Jun 2, 2012 this sequence version replaced NM_001002269.1. Transcript Variant: This variant (2) lacks an exon in the coding region that causes a frameshift and leads to an early stop codon compared to variant 1. The resulting protein (isoform 2) is shorter and has a distinct C-terminus compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660803.215204.1, SRR1660803.107687.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2153932, SAMEA2467146 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCCGAAC CTGCGTCTGT CGCGGCTGAA TCTCTCGCGG GCAGCAGGGC GCGCGCTGCA 
CGCACAGTAC TAGGTCAGGT GGTGCTCCCG GGTGAGGAGC TGCTCCTGCC GGAACAGGAG 
GACGCGGAAG GCCCTGGGGG TGCAGTGGAG CGACCGTTGA GCCTGAATGC TAGAGCGTGC 
TCGCGGGTGC GCGTTGTATG CGGTCCGGGC CTTCGGCGCT GTGGGGACCG CCTGCTGGTC 
ACCAAGTGCG GCCGCCTCCG TCACAAGGAG CCCGGCAGTG GCAGCGGCGG CGGTGTTTAC 
TGGGTGGACT CTCAGCAGAA GCGGTATGTT CCAGTAAAAG GAGACCATGT GATTGGCATA 
GTGACAGCTA AATCTGGAGA TATATTCAAA GTTGATGTTG GAGGGAGTGA GCCAGCTTCT 
TTGTCTTACT TGTCATTTGA AGGTGCAACT AAAAGAAACA GACCAAATGT GCAGGCTATT 
AGCTCCAGAT TGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001002269.1
CDS	49..543
Translation	MAEPASVAAESLAGSRARAARTVLGQVVLPGEELLLPEQEDAEGPGGAVERPLSLNARACSRVRVVCGPGLRRCGDRLLVTKCGRLRHKEPGSGSGGGVYWVDSQQKRYVPVKGDHVIGIVTAKSGDIFKVDVGGSEPASLSYLSFEGATKRNRPNVQAISSRL

Target ORF information:

RefSeq Version	NM_001002269.2
Organism	Homo sapiens(human)
Definition	Homo sapiens exosome component 3 (EXOSC3), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001002269.2

ORF Insert Sequence:

ATGGCCGAAC CTGCGTCTGT CGCGGCTGAA TCTCTCGCGG GCAGCAGGGC GCGCGCTGCA 
CGCACAGTAC TAGGTCAGGT GGTGCTCCCG GGTGAGGAGC TGCTCCTGCC GGAACAGGAG 
GACGCGGAAG GCCCTGGGGG TGCAGTGGAG CGACCGTTGA GCCTGAATGC TAGAGCGTGC 
TCGCGGGTGC GCGTTGTATG CGGTCCGGGC CTTCGGCGCT GTGGGGACCG CCTGCTGGTC 
ACCAAGTGCG GCCGCCTCCG TCACAAGGAG CCCGGCAGTG GCAGCGGCGG CGGTGTTTAC 
TGGGTGGACT CTCAGCAGAA GCGGTATGTT CCAGTAAAAG GAGACCATGT GATTGGCATA 
GTGACAGCTA AATCTGGAGA TATATTCAAA GTTGATGTTG GAGGGAGTGA GCCAGCTTCT 
TTGTCTTACT TGTCATTTGA AGGTGCAACT AAAAGAAACA GACCAAATGT GCAGGCTATT 
AGCTCCAGAT TGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Recessive mutation in EXOSC3 associates with mitochondrial dysfunction and pontocerebellar hypoplasia.
Mitochondrion3746-54(2017 Nov)
Schottmann G,Picker-Minh S,Schwarz JM,Gill E,Rodenburg RJT,Stenzel W,Kaindl AM,Schuelke M

Architecture of the human interactome defines protein communities and disease networks.
Nature545(7655)505-509(2017 05)
Huttlin EL,Bruckner RJ,Paulo JA,Cannon JR,Ting L,Baltier K,Colby G,Gebreab F,Gygi MP,Parzen H,Szpyt J,Tam S,Zarraga G,Pontano-Vaites L,Swarup S,White AE,Schweppe DK,Rad R,Erickson BK,Obar RA,Guruharsha KG,Li K,Artavanis-Tsakonas S,Gygi SP,Harper JW

Mutations of EXOSC3/Rrp40p associated with neurological diseases impact ribosomal RNA processing functions of the exosome in
RNA (New York, N.Y.)23(4)466-472(2017 04)
Gillespie A,Gabunilas J,Jen JC,Chanfreau GF

Altered RNA metabolism due to a homozygous RBM7 mutation in a patient with spinal motor neuropathy.
Human molecular genetics25(14)2985-2996(2016 07)
Giunta M,Edvardson S,Xu Y,Schuelke M,Gomez-Duran A,Boczonadi V,Elpeleg O,M?ller JS,Horvath R

A human interactome in three quantitative dimensions organized by stoichiometries and abundances.
Cell163(3)712-23(2015 Oct)
Hein MY,Hubner NC,Poser I,Cox J,Nagaraj N,Toyoda Y,Gak IA,Weisswange I,Mansfeld J,Buchholz F,Hyman AA,Mann M

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EXOSC3 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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