SHANK1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	SHANK1
Entrez Gene ID	50944
Full Name	SH3 and multiple ankyrin repeat domains 1
Synonyms	SPANK-1,SSTRIP,synamon
General protein information	Preferred Names SH3 and multiple ankyrin repeat domains 1 Names SH3 and multiple ankyrin repeat domains protein 1 SSTR-interacting protein somatostatin receptor-interacting protein
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 19 Map Location: 19q13.33
Summary	This gene encodes a member of the SHANK (SH3 domain and ankyrin repeat containing) family of proteins. Members of this family act as scaffold proteins that are required for the development and function of neuronal synapses. Deletions in this gene may be associated with autism spectrum disorder in males. [provided by RefSeq, Apr 2016].
Disorder MIM:	604999

mRNA and Protein(s)

mRNA	Protein	Name
XM_011527014.2	XP_011525316.1	SH3 and multiple ankyrin repeat domains protein 1 isoform X2
NM_016148.3	NP_057232.2	SH3 and multiple ankyrin repeat domains protein 1
XM_006723233.3	XP_006723296.1	SH3 and multiple ankyrin repeat domains protein 1 isoform X2
NM_016148.4	NP_057232.2	SH3 and multiple ankyrin repeat domains protein 1
XM_011527013.2	XP_011525315.1	SH3 and multiple ankyrin repeat domains protein 1 isoform X1
NM_016148.5	NP_057232.2	SH3 and multiple ankyrin repeat domains protein 1

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	SHANK1	XP_005616915.1
Xenopus tropicalis (tropical clawed frog)	shank1	XP_002938582.2
Homo sapiens (human)	SHANK1	NP_057232.2
	LOC719673	XP_002808253.1
Bos taurus (cattle)	SHANK1	XP_002695260.2
Mus musculus (house mouse)	Shank1	NP_001029287.1
Rattus norvegicus (Norway rat)	Shank1	NP_113939.2

Gene Ontology
Bibliography

Related articles in PubMed

Behavioral phenotypes and neurobiological mechanisms in the Shank1 mouse model for autism spectrum disorder: A translational perspective.
Sungur A?, Schwarting RKW, W?hr M
Behavioural brain research(2017 Sep)

SHANK proteins limit integrin activation by directly interacting with Rap1 and?R-Ras.
Lilja J, Zacharchenko T, Georgiadou M, Jacquemet G, De Franceschi N, Peuhu E, Hamidi H, Pouwels J, Martens V, Nia FH, Beifuss M, Boeckers T, Kreienkamp HJ, Barsukov IL, Ivaska J
Nature cell biology19(4)292-305(2017 Apr)

Meta-analysis of SHANK Mutations in Autism Spectrum Disorders: a gradient of severity in cognitive impairments.
Leblond CS, Nava C, Polge A, Gauthier J, Huguet G, Lumbroso S, Giuliano F, Stordeur C, Depienne C, Mouzat K, Pinto D, Howe J, Lemi?re N, Durand CM, Guibert J, Ey E, Toro R, Peyre H, Mathieu A, Amsellem F, Rastam M, Gillberg IC, Rappold GA, Holt R, Monaco AP, Maestrini E, Galan P, Heron D, Jacquette A, Afenjar A, Rastetter A, Brice A, Devillard F, Assouline B, Laffargue F, Lespinasse J, Chiesa J, Rivier F, Bonneau D, Regnault B, Zelenika D, Delepine M, Lathrop M, Sanlaville D, Schluth-Bolard C, Edery P, Perrin L, Tabet AC, Schmeisser MJ, Boeckers TM, Coleman M, Sato D, Szatmari P, Scherer SW, Rouleau GA, Betancur C, Leboyer M, Gillberg C, Delorme R, Bourgeron T
PLoS genetics10(9)e1004580(2014 Sep)

FMRP interacts with G-quadruplex structures in the 3'-UTR of its dendritic target Shank1 mRNA.
Zhang Y, Gaetano CM, Williams KR, Bassell GJ, Mihailescu MR
RNA biology11(11)1364-74(2014)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

SHANK1 and SHANK3 act as integrin activation inhibitors by sequestering active Rap1 and R-Ras via the SPN domain and thus limiting their bioavailability at the plasma membrane.
Title: SHANK proteins limit integrin activation by directly interacting with Rap1 and?R-Ras.

a non-canonical initiation site is required for efficient translation of the dendritically localized Shank1 mRNA
Title: A non-canonical initiation site is required for efficient translation of the dendritically localized Shank1 mRNA.

Data show that the Shank1 protein mRNA 3' UTR adopts two very stable intramolecular G-quadruplexes which are bound specifically and with high affinity by X mental retardation protein (FMRP).
Title: FMRP interacts with G-quadruplex structures in the 3'-UTR of its dendritic target Shank1 mRNA.

A hemizygous SHANK1 deletion segregates in a four-generation family in which male carriers--but not female carriers--have autism spectrum disorder with higher functioning.
Title: SHANK1 Deletions in Males with Autism Spectrum Disorder.

The results of this study suggested a role of SHANK1 in working memory deficits in schizophrenia.
Title: A promoter variant of SHANK1 affects auditory working memory in schizophrenia patients and in subjects clinically at risk for psychosis.

The following SHANK1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SHANK1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu07151	NM_016148.5 Latest version!	Homo sapiens SH3 and multiple ankyrin repeat domains 1 (SHANK1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$659.50-$923.30 $1319.00
OHu07151	XM_006723233.3 Latest version!	Homo sapiens SH3 and multiple ankyrin repeat domains 1 (SHANK1), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$659.50-$923.30 $1319.00
OHu52292	XM_011527013.2 Latest version!	Homo sapiens SH3 and multiple ankyrin repeat domains 1 (SHANK1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$1091.30 $1559.00
OHu52293	XM_011527014.2 Latest version!	Homo sapiens SH3 and multiple ankyrin repeat domains 1 (SHANK1), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$1091.30 $1559.00
View Old Accession Versions >>
OHu07151	NM_016148.3	Homo sapiens SH3 and multiple ankyrin repeat domains 1 (SHANK1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$659.50-$923.30 $1319.00
OHu07151	NM_016148.4	Homo sapiens SH3 and multiple ankyrin repeat domains 1 (SHANK1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$659.50-$923.30 $1319.00
Hide Old Accession Versions >>

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***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

SHANK1 ( NM_016148.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_057232.2 Homo sapiens SH3 and multiple ankyrin repeat domains 1 (SHANK1), mRNA.

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CloneID	OHu07151
Clone ID Related Accession (Same CDS sequence)	NM_016148.3 , XM_006723233.3 , NM_016148.4 , NM_016148.5
Accession Version	NM_016148.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 6486bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-04-22
Organism	Homo sapiens(Human)
Product	SH3 and multiple ankyrin repeat domains protein 1
Comment	REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF163302.1, AC008743.9 and BU633092.1. On Apr 9, 2016 this sequence version replaced NM_016148.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF163302.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGACCCACA GCCCCGCGAC AAGCGAGGAC GAGGAACGCC ACAGTGCCAG CGAGTGTCCC 
GAGGGGGGCT CAGAGTCCGA CAGCTCCCCA GACGGGCCAG GTCGAGGCCC CCGGGGGACC 
CGGGGCCAGG GCAGTGGGGC ACCTGGTAGC CTGGCCTCTG TTAGAGGCCT CCAGGGCCGC 
TCAATGTCCG TCCCAGACGA CGCCCACTTC AGCATGATGG TCTTCAGGAT TGGCATCCCG 
GACCTGCACC AGACAAAATG CCTTCGCTTC AACCCCGATG CCACCATCTG GACGGCCAAG 
CAGCAGGTGC TCTGTGCCCT GAGCGAGAGC CTGCAGGATG TGCTCAACTA TGGCCTGTTC 
CAACCGGCCA CCTCCGGCCG CGATGCCAAC TTCCTGGAGG AGGAGAGGCT GCTGCGGGAG 
TACCCCCAGT CCTTTGAGAA GGGGGTCCCC TACCTGGAGT TCCGATACAA GACCCGAGTT 
TACAAACAGA CCAACCTGGA TGAGAAGCAG CTGGCCAAGT TGCACACGAA GACGGGGTTG 
AAGAAGTTCC TGGAGTATGT GCAGCTCGGG ACATCTGACA AGGTGGCGCG GCTGCTGGAC 
AAGGGGCTGG ACCCCAATTA CCATGACTCG GATTCGGGAG AGACCCCCTT GACACTGGCG 
GCCCAGACCG AAGGCTCTGT AGAGGTGATT CGAACCCTGT GCCTGGGCGG GGCCCACATT 
GACTTCCGGG CCCGGGATGG CATGACCGCA CTGCATAAGG CCGCATGCGC CCGACACTGC 
CTGGCACTCA CGGCGCTCCT GGACCTTGGG GGTTCCCCCA ACTACAAGGA CCGTCGGGGG 
CTGACCCCTC TGTTCCACAC GGCCATGGTG GGTGGTGACC CCCGATGCTG CGAGCTGCTC 
CTGTTCAACA GGGCCCAGCT GGGCATAGCT GATGAGAACG GCTGGCAGGA AATCCACCAG 
GCCTGCCAGC GGGGTCACTC TCAGCACCTG GAGCATCTGC TTTTCTACGG GGCTGAGCCT 
GGAGCCCAGA ACGCCTCGGG GAACACGGCT CTGCACATCT GCGCCCTCTA CAACAAGGAG 
ACCTGTGCCA GGATCCTCCT GTATCGAGGT GCCGACAAGG ATGTGAAGAA CAACAACGGA 
CAGACCCCCT TCCAGGTGGC AGTGATTGCT GGGAATTTTG AGCTGGGGGA GCTGATCCGA 
AACCACCGAG AACAGGATGT GGTGCCCTTC CAGGAGTCCC CCAAGTACGC GGCCCGGCGA 
CGGGGGCCCC CAGGCACAGG GCTGACGGTG CCCCCGGCGC TGCTGCGGGC CAACAGTGAC 
ACCAGCATGG CGCTGCCCGA CTGGATGGTG TTCTCCGCCC CGGGGGCCGC GTCCTCTGGG 
GCCCCTGGCC CTACCTCAGG GTCCCAGGGC CAGTCGCAGC CCTCGGCCCC CACCACCAAG 
CTCAGCAGCG GGACCCTCCG AAGTGCCAGC AGCCCCCGGG GTGCCAGGGC CCGCTCTCCA 
TCCCGAGGGA GGCACCCTGA GGACGCCAAG AGGCAGCCCC GAGGCCGGCC CAGCTCCAGC 
GGGACACCCC GGGAAGGGCC AGCCGGGGGC ACGGGGGGCT CAGGGGGCCC CGGGGGCTCC 
CTGGGCAGCC GCGGGAGGCG GAGGAAGCTC TACTCAGCGG TACCCGGACG CTCCTTCATG 
GCTGTGAAGT CCTACCAGGC CCAAGCCGAG GGGGAGATCT CCCTGAGCAA GGGCGAGAAG 
ATCAAAGTAC TTAGCATCGG GGAAGGAGGC TTCTGGGAAG GCCAGGTCAA AGGTCGTGTT 
GGCTGGTTCC CCTCTGACTG CCTGGAAGAA GTGGCGAATC GCTCTCAGGA GAGCAAGCAA 
GAAAGCCGCA GTGACAAGGC AAAGAGACTC TTCCGGCATT ATACCGTGGG CTCCTACGAC 
AGCTTTGATG CCCCAAGCTT AATGGATGGG ATTGGCCCAG GGAGCGATTA CATCATTAAG 
GAGAAGACAG TCTTGCTGCA GAAGAAGGAC AGTGAGGGGT TTGGGTTCGT GCTCCGGGGG 
GCCAAGGCGC AGACCCCCAT CGAGGAGTTC ACCCCCACCC CGGCCTTCCC GGCGCTGCAG 
TACCTGGAGT CGGTGGACGA GGGTGGCGTG GCATGGCGAG CTGGACTGCG AATGGGAGAC 
TTCCTCATCG AGGTGAACGG GCAGAATGTG GTGAAGGTCG GCCACCGACA GGTGGTGAAC 
ATGATCCGCC AAGGGGGCAA CACGCTGATG GTGAAGGTGG TGATGGTCAC CAGGCACCCG 
GACATGGATG AGGCAGTGCA CAAGAAAGCA CCCCAGCAGG CCAAGCGGCT GCCGCCCCCA 
ACCATCTCCC TGCGTTCCAA ATCTATGACC TCAGAGCTGG AGGAGATGGA GTACGAGCAG 
CAGCCGGCGC CGGTGCCCAG CATGGAGAAA AAGCGGACCG TGTATCAGAT GGCTCTCAAC 
AAACTGGACG AAATCCTGGC CGCAGCTCAA CAGACCATCA GTGCAAGCGA AAGCCCTGGT 
CCCGGTGGCC TCGCGTCCCT GGGCAAACAC CGACCCAAAG GTTTCTTTGC CACTGAGTCG 
AGCTTCGATC CCCACCACCG TGCCCAGCCA AGTTACGAGC GTCCTTCTTT CCTGCCTCCA 
GGACCTGGGT TGATGCTCCG GCAAAAATCT ATCGGTGCGG CAGAAGATGA CAGACCTTAC 
CTAGCACCCC CAGCCATGAA ATTCAGCCGC AGCCTGTCTG TGCCTGGTTC GGAGGACATT 
CCCCCGCCAC CCACCACGTC CCCACCGGAG CCTCCCTACA GCACACCTCC AGTCCCCTCC 
TCCTCAGGGC GCCTCACCCC CTCCCCTCGG GGAGGGCCCT TCAACCCTGG CTCTGGTGGC 
CCCCTCCCCG CCTCCTCCCC TGCATCCTTT GACGGGCCCT CCCCTCCCGA CACTCGCGTG 
GGGAGCCGCG AGAAGAGCCT GTACCACAGT GGGCCCCTGC CCCCGGCCCA CCACCACCCG 
CCCCACCACC ACCACCACCA CGCCCCGCCC CCTCAGCCCC ACCACCACCA CGCCCACCCC 
CCTCATCCTC CCGAGATGGA GACAGGCGGC TCTCCCGACG ACCCTCCACC CCGCCTGGCT 
CTGGGGCCCC AGCCCAGCCT GCGAGGCTGG AGGGGCGGCG GGCCCAGCCC GACCCCGGGG 
GCCCCGTCCC CATCGCACCA CGGCAGCGCG GGCGGGGGCG GCGGCTCCTC CCAGGGCCCG 
GCTCTACGCT ATTTCCAGCT GCCCCCGCGG GCGGCCAGCG CAGCCATGTA CGTGCCCGCC 
CGCTCGGGCC GCGGCCGCAA GGGCCCGCTG GTCAAGCAGA CCAAGGTGGA AGGCGAGCCC 
CAGAAGGGCG GCGGCCTCCC GCCCGCGCCG TCGCCCACGT CCCCGGCCTC CCCGCAGCCG 
CCGCCCGCCG TGGCCGCGCC CTCGGAGAAG AACTCCATCC CCATCCCCAC CATCATCATC 
AAGGCCCCGT CCACCAGTAG CAGCGGCCGC AGCAGCCAGG GCAGCAGCAC CGAGGCGGAG 
CCCCCCACCC AGCCGGAGCC CACGGGAGGC GGCGGCGGCG GCGGCTCCTC GCCCAGCCCC 
GCCCCGGCCA TGTCACCCGT GCCCCCGTCC CCCTCGCCCG TGCCCACCCC CGCCTCGCCC 
AGCGGCCCGG CCACGCTGGA CTTCACGAGC CAGTTCGGGG CCGCCCTGGT GGGGGCGGCC 
CGGAGGGAGG GGGGCTGGCA GAATGAGGCG CGCCGGCGCT CCACGCTGTT CCTGTCCACC 
GACGCGGGGG ACGAGGACGG CGGGGACGGC GGGCTGGGCA CAGGGGCGGC CCCGGGCCCG 
CGGCTGCGCC ACTCCAAATC CATCGACGAG GGCATGTTCT CCGCCGAGCC CTACCTCCGA 
CTGGAGTCTG CGGGCAGCGG CGCGGGCTAC GGCGGCTACG GGGCCGGTAG CCGAGCCTAC 
GGGGGTGGCG GGGGCAGCAG CGCCTTCACC AGCTTCCTGC CCCCGCGACC CCTGGTGCAC 
CCGCTGACCG GCAAGGCCCT GGATCCCGCC TCCCCGCTGG GGCTGGCCCT GGCCGCCCGC 
GAGCGAGCGC TGAAGGAGTC CTCGGAGGGC GGCGGGGCCC CCCAGCCGCC TCCCAGGCCC 
CCATCGCCCC GCTACGAGGC CCCGCCGCCC ACCCCGCACC ACCACTCGCC CCACGCCCAC 
CACGAGCCAG TGCTGCGTCT CTGGGGGGCC TCCCCGCCGG ACCCTGCGCG CCGGGAGCTG 
GGGTACAGGG CCGGGCTGGG CAGCCAGGAG AAGTCCCTTC CCGCCAGCCC GCCCGCCGCC 
CGGCGTTCCC TGCTACACCG CCTGCCGCCC ACCGCTCCCG GGGTGGGGCC CCTCCTGCTG 
CAGCTGGGGA CGGAGCCCCC GGCCCCGCAC CCCGGAGTAA GCAAGCCCTG GAGGTCCGCA 
GCCCCCGAAG AACCCGAGCG GCTGCCGCTG CACGTGCGGT TCCTTGAAAA CTGCCAGCCC 
CGGGCCCCTG TGACGAGCGG AAGGGGTCCC CCCTCGGAGG ACGGGCCGGG GGTCCCGCCG 
CCCAGCCCAC GCCGGTCCGT GCCCCCCTCC CCGACCTCCC CGAGGGCCAG CGAAGAGAAC 
GGGCTGCCCC TGCTGGTCCT GCCGCCTCCC GCCCCCTCGG TGGATGTGGA AGATGGCGAA 
TTCCTTTTCG TGGAACCGCT GCCTCCGCCT CTGGAATTCT CCAACAGCTT CGAAAAGCCA 
GAGTCGCCCC TCACGCCTGG GCCTCCCCAC CCGCTGCCCG ACACACCTGC CCCTGCCACC 
CCGTTACCCC CTGTGCCACC CCCGGCTGTG GCCGCAGCCC CTCCCACCCT GGACTCCACC 
GCATCCAGCC TGACATCCTA TGACAGCGAG GTGGCCACCC TGACCCAGGG GGCCTCCGCC 
GCTCCTGGGG ACCCCCATCC ACCAGGCCCG CCTGCCCCAG CAGCACCGGC TCCCGCTGCC 
CCACAGCCTG GCCCGGACCC TCCGCCTGGC ACGGATTCTG GCATCGAGGA GGTGGACAGT 
CGGAGCAGCA GTGACCACCC ACTGGAGACC ATCAGCAGCG CCTCCACGCT GAGCAGCCTA 
TCTGCCGAAG GTGGTGGCAG CGCAGGGGGT GGGGGCGGGG CTGGGGCCGG TGTGGCCAGT 
GGGCCGGAGC TTCTGGACAC CTATGTGGCC TACCTGGACG GCCAGGCCTT TGGGGGCAGC 
AGTACTCCCG GCCCGCCATA CCCTCCTCAG CTCATGACTC CCTCTAAGCT CCGGGGCCGG 
GCGCTAGGAG CCAGCGGAGG CCTGCGGCCT GGCCCCAGCG GGGGACTCCG AGACCCTGTT 
ACCCCCACCA GCCCCACCGT CTCGGTGACA GGGGCTGGAA CCGATGGGCT GCTGGCCCTG 
CGTGCTTGTT CAGGACCCCC CACGGCAGGC GTGGCGGGGG GTCCGGTGGC TGTAGAGCCA 
GAAGTCCCAC CGGTGCCCTT GCCGACGGCC TCCTCTCTGC CCCGGAAGCT GCTGCCCTGG 
GAGGAGGGCC CGGGCCCACC GCCACCACCT CTGCCCGGGC CCTTGGCCCA GCCTCAGGCC 
TCAGCCTTGG CCACAGTAAA AGCCAGCATC ATCAGTGAAC TCAGCTCCAA GCTTCAGCAG 
TTTGGGGGCT CCTCGGCAGC TGGCGGCGCT CTGCCCTGGG CCCGAGGAGG CAGTGGGGGA 
GGCGGAGACA GCCACCACGG GGGAGCCAGC TATGTCCCCG AGAGGACCTC CTCCCTGCAG 
CGGCAGAGAC TCTCCGACGA CTCCCAGTCC TCACTCCTCT CCAAGCCTGT CAGCAGCCTG 
TTTCAGAACT GGCCCAAACC ACCTCTGCCG CCACTCCCCA CCGGAACAGG GGTCTCCCCT 
ACAGCCGCTG CGGCCCCAGG GGCCACCTCA CCCTCAGCCT CCTCCTCCTC CACGTCCACC 
CGCCACCTCC AGGGCGTGGA GTTCGAGATG CGGCCCCCTC TGCTCCGCCG GGCCCCCAGC 
CCCTCGCTGC TGCCCGCCTC GGAGCACAAG GTCAGCCCTG CGCCCAGGCC CTCGTCCCTG 
CCCATCCTGC CTTCCGGACC CCTCTACCCA GGCCTCTTTG ACATCCGTGG CTCCCCAACT 
GGAGGGGCAG GAGGCTCGGC TGACCCCTTC GCCCCAGTCT TTGTGCCGCC ACACCCGGGG 
ATATCCGGGG GGCTCGGGGG AGCCTTGTCA GGGGCCTCGC GCTCCCTCTC ACCGACCCGC 
CTGCTCTCGC TGCCCCCGGA CAAGCCGTTT GGCGCTAAAC CTCTGGGGTT CTGGACCAAG 
TTCGACGTGG CTGATTGGCT GGAGTGGCTG GGTTTGGCGG AGCACCGAGC CCAGTTCCTG 
GACCACGAGA TCGATGGCTC CCACCTGCCC GCCTTGACCA AGGAGGACTA CGTCGATCTA 
GGTGTGACCA GGGTGGGCCA CCGCATGAAC ATCGACCGGG CTCTCAAATT CTTCCTGGAG 
AGGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_057232.2
CDS	20..6505
Translation	MTHSPATSEDEERHSASECPEGGSESDSSPDGPGRGPRGTRGQGSGAPGSLASVRGLQGRSMSVPDDAHFSMMVFRIGIPDLHQTKCLRFNPDATIWTAKQQVLCALSESLQDVLNYGLFQPATSGRDANFLEEERLLREYPQSFEKGVPYLEFRYKTRVYKQTNLDEKQLAKLHTKTGLKKFLEYVQLGTSDKVARLLDKGLDPNYHDSDSGETPLTLAAQTEGSVEVIRTLCLGGAHIDFRARDGMTALHKAACARHCLALTALLDLGGSPNYKDRRGLTPLFHTAMVGGDPRCCELLLFNRAQLGIADENGWQEIHQACQRGHSQHLEHLLFYGAEPGAQNASGNTALHICALYNKETCARILLYRGADKDVKNNNGQTPFQVAVIAGNFELGELIRNHREQDVVPFQESPKYAARRRGPPGTGLTVPPALLRANSDTSMALPDWMVFSAPGAASSGAPGPTSGSQGQSQPSAPTTKLSSGTLRSASSPRGARARSPSRGRHPEDAKRQPRGRPSSSGTPREGPAGGTGGSGGPGGSLGSRGRRRKLYSAVPGRSFMAVKSYQAQAEGEISLSKGEKIKVLSIGEGGFWEGQVKGRVGWFPSDCLEEVANRSQESKQESRSDKAKRLFRHYTVGSYDSFDAPSLMDGIGPGSDYIIKEKTVLLQKKDSEGFGFVLRGAKAQTPIEEFTPTPAFPALQYLESVDEGGVAWRAGLRMGDFLIEVNGQNVVKVGHRQVVNMIRQGGNTLMVKVVMVTRHPDMDEAVHKKAPQQAKRLPPPTISLRSKSMTSELEEMEYEQQPAPVPSMEKKRTVYQMALNKLDEILAAAQQTISASESPGPGGLASLGKHRPKGFFATESSFDPHHRAQPSYERPSFLPPGPGLMLRQKSIGAAEDDRPYLAPPAMKFSRSLSVPGSEDIPPPPTTSPPEPPYSTPPVPSSSGRLTPSPRGGPFNPGSGGPLPASSPASFDGPSPPDTRVGSREKSLYHSGPLPPAHHHPPHHHHHHAPPPQPHHHHAHPPHPPEMETGGSPDDPPPRLALGPQPSLRGWRGGGPSPTPGAPSPSHHGSAGGGGGSSQGPALRYFQLPPRAASAAMYVPARSGRGRKGPLVKQTKVEGEPQKGGGLPPAPSPTSPASPQPPPAVAAPSEKNSIPIPTIIIKAPSTSSSGRSSQGSSTEAEPPTQPEPTGGGGGGGSSPSPAPAMSPVPPSPSPVPTPASPSGPATLDFTSQFGAALVGAARREGGWQNEARRRSTLFLSTDAGDEDGGDGGLGTGAAPGPRLRHSKSIDEGMFSAEPYLRLESAGSGAGYGGYGAGSRAYGGGGGSSAFTSFLPPRPLVHPLTGKALDPASPLGLALAARERALKESSEGGGAPQPPPRPPSPRYEAPPPTPHHHSPHAHHEPVLRLWGASPPDPARRELGYRAGLGSQEKSLPASPPAARRSLLHRLPPTAPGVGPLLLQLGTEPPAPHPGVSKPWRSAAPEEPERLPLHVRFLENCQPRAPVTSGRGPPSEDGPGVPPPSPRRSVPPSPTSPRASEENGLPLLVLPPPAPSVDVEDGEFLFVEPLPPPLEFSNSFEKPESPLTPGPPHPLPDTPAPATPLPPVPPPAVAAAPPTLDSTASSLTSYDSEVATLTQGASAAPGDPHPPGPPAPAAPAPAAPQPGPDPPPGTDSGIEEVDSRSSSDHPLETISSASTLSSLSAEGGGSAGGGGGAGAGVASGPELLDTYVAYLDGQAFGGSSTPGPPYPPQLMTPSKLRGRALGASGGLRPGPSGGLRDPVTPTSPTVSVTGAGTDGLLALRACSGPPTAGVAGGPVAVEPEVPPVPLPTASSLPRKLLPWEEGPGPPPPPLPGPLAQPQASALATVKASIISELSSKLQQFGGSSAAGGALPWARGGSGGGGDSHHGGASYVPERTSSLQRQRLSDDSQSSLLSKPVSSLFQNWPKPPLPPLPTGTGVSPTAAAAPGATSPSASSSSTSTRHLQGVEFEMRPPLLRRAPSPSLLPASEHKVSPAPRPSSLPILPSGPLYPGLFDIRGSPTGGAGGSADPFAPVFVPPHPGISGGLGGALSGASRSLSPTRLLSLPPDKPFGAKPLGFWTKFDVADWLEWLGLAEHRAQFLDHEIDGSHLPALTKEDYVDLGVTRVGHRMNIDRALKFFLER

Target ORF information:

RefSeq Version	NM_016148.3
Organism	Homo sapiens(Human)
Definition	Homo sapiens SH3 and multiple ankyrin repeat domains 1 (SHANK1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_016148.3

ORF Insert Sequence:

ATGACCCACA GCCCCGCGAC AAGCGAGGAC GAGGAACGCC ACAGTGCCAG CGAGTGTCCC 
GAGGGGGGCT CAGAGTCCGA CAGCTCCCCA GACGGGCCAG GTCGAGGCCC CCGGGGGACC 
CGGGGCCAGG GCAGTGGGGC ACCTGGTAGC CTGGCCTCTG TTAGAGGCCT CCAGGGCCGC 
TCAATGTCCG TCCCAGACGA CGCCCACTTC AGCATGATGG TCTTCAGGAT TGGCATCCCG 
GACCTGCACC AGACAAAATG CCTTCGCTTC AACCCCGATG CCACCATCTG GACGGCCAAG 
CAGCAGGTGC TCTGTGCCCT GAGCGAGAGC CTGCAGGATG TGCTCAACTA TGGCCTGTTC 
CAACCGGCCA CCTCCGGCCG CGATGCCAAC TTCCTGGAGG AGGAGAGGCT GCTGCGGGAG 
TACCCCCAGT CCTTTGAGAA GGGGGTCCCC TACCTGGAGT TCCGATACAA GACCCGAGTT 
TACAAACAGA CCAACCTGGA TGAGAAGCAG CTGGCCAAGT TGCACACGAA GACGGGGTTG 
AAGAAGTTCC TGGAGTATGT GCAGCTCGGG ACATCTGACA AGGTGGCGCG GCTGCTGGAC 
AAGGGGCTGG ACCCCAATTA CCATGACTCG GATTCGGGAG AGACCCCCTT GACACTGGCG 
GCCCAGACCG AAGGCTCTGT AGAGGTGATT CGAACCCTGT GCCTGGGCGG GGCCCACATT 
GACTTCCGGG CCCGGGATGG CATGACCGCA CTGCATAAGG CCGCATGCGC CCGACACTGC 
CTGGCACTCA CGGCGCTCCT GGACCTTGGG GGTTCCCCCA ACTACAAGGA CCGTCGGGGG 
CTGACCCCTC TGTTCCACAC GGCCATGGTG GGTGGTGACC CCCGATGCTG CGAGCTGCTC 
CTGTTCAACA GGGCCCAGCT GGGCATAGCT GATGAGAACG GCTGGCAGGA AATCCACCAG 
GCCTGCCAGC GGGGTCACTC TCAGCACCTG GAGCATCTGC TTTTCTACGG GGCTGAGCCT 
GGAGCCCAGA ACGCCTCGGG GAACACGGCT CTGCACATCT GCGCCCTCTA CAACAAGGAG 
ACCTGTGCCA GGATCCTCCT GTATCGAGGT GCCGACAAGG ATGTGAAGAA CAACAACGGA 
CAGACCCCCT TCCAGGTGGC AGTGATTGCT GGGAATTTTG AGCTGGGGGA GCTGATCCGA 
AACCACCGAG AACAGGATGT GGTGCCCTTC CAGGAGTCCC CCAAGTACGC GGCCCGGCGA 
CGGGGGCCCC CAGGCACAGG GCTGACGGTG CCCCCGGCGC TGCTGCGGGC CAACAGTGAC 
ACCAGCATGG CGCTGCCCGA CTGGATGGTG TTCTCCGCCC CGGGGGCCGC GTCCTCTGGG 
GCCCCTGGCC CTACCTCAGG GTCCCAGGGC CAGTCGCAGC CCTCGGCCCC CACCACCAAG 
CTCAGCAGCG GGACCCTCCG AAGTGCCAGC AGCCCCCGGG GTGCCAGGGC CCGCTCTCCA 
TCCCGAGGGA GGCACCCTGA GGACGCCAAG AGGCAGCCCC GAGGCCGGCC CAGCTCCAGC 
GGGACACCCC GGGAAGGGCC AGCCGGGGGC ACGGGGGGCT CAGGGGGCCC CGGGGGCTCC 
CTGGGCAGCC GCGGGAGGCG GAGGAAGCTC TACTCAGCGG TACCCGGACG CTCCTTCATG 
GCTGTGAAGT CCTACCAGGC CCAAGCCGAG GGGGAGATCT CCCTGAGCAA GGGCGAGAAG 
ATCAAAGTAC TTAGCATCGG GGAAGGAGGC TTCTGGGAAG GCCAGGTCAA AGGTCGTGTT 
GGCTGGTTCC CCTCTGACTG CCTGGAAGAA GTGGCGAATC GCTCTCAGGA GAGCAAGCAA 
GAAAGCCGCA GTGACAAGGC AAAGAGACTC TTCCGGCATT ATACCGTGGG CTCCTACGAC 
AGCTTTGATG CCCCAAGCTT AATGGATGGG ATTGGCCCAG GGAGCGATTA CATCATTAAG 
GAGAAGACAG TCTTGCTGCA GAAGAAGGAC AGTGAGGGGT TTGGGTTCGT GCTCCGGGGG 
GCCAAGGCGC AGACCCCCAT CGAGGAGTTC ACCCCCACCC CGGCCTTCCC GGCGCTGCAG 
TACCTGGAGT CGGTGGACGA GGGTGGCGTG GCATGGCGAG CTGGACTGCG AATGGGAGAC 
TTCCTCATCG AGGTGAACGG GCAGAATGTG GTGAAGGTCG GCCACCGACA GGTGGTGAAC 
ATGATCCGCC AAGGGGGCAA CACGCTGATG GTGAAGGTGG TGATGGTCAC CAGGCACCCG 
GACATGGATG AGGCAGTGCA CAAGAAAGCA CCCCAGCAGG CCAAGCGGCT GCCGCCCCCA 
ACCATCTCCC TGCGTTCCAA ATCTATGACC TCAGAGCTGG AGGAGATGGA GTACGAGCAG 
CAGCCGGCGC CGGTGCCCAG CATGGAGAAA AAGCGGACCG TGTATCAGAT GGCTCTCAAC 
AAACTGGACG AAATCCTGGC CGCAGCTCAA CAGACCATCA GTGCAAGCGA AAGCCCTGGT 
CCCGGTGGCC TCGCGTCCCT GGGCAAACAC CGACCCAAAG GTTTCTTTGC CACTGAGTCG 
AGCTTCGATC CCCACCACCG TGCCCAGCCA AGTTACGAGC GTCCTTCTTT CCTGCCTCCA 
GGACCTGGGT TGATGCTCCG GCAAAAATCT ATCGGTGCGG CAGAAGATGA CAGACCTTAC 
CTAGCACCCC CAGCCATGAA ATTCAGCCGC AGCCTGTCTG TGCCTGGTTC GGAGGACATT 
CCCCCGCCAC CCACCACGTC CCCACCGGAG CCTCCCTACA GCACACCTCC AGTCCCCTCC 
TCCTCAGGGC GCCTCACCCC CTCCCCTCGG GGAGGGCCCT TCAACCCTGG CTCTGGTGGC 
CCCCTCCCCG CCTCCTCCCC TGCATCCTTT GACGGGCCCT CCCCTCCCGA CACTCGCGTG 
GGGAGCCGCG AGAAGAGCCT GTACCACAGT GGGCCCCTGC CCCCGGCCCA CCACCACCCG 
CCCCACCACC ACCACCACCA CGCCCCGCCC CCTCAGCCCC ACCACCACCA CGCCCACCCC 
CCTCATCCTC CCGAGATGGA GACAGGCGGC TCTCCCGACG ACCCTCCACC CCGCCTGGCT 
CTGGGGCCCC AGCCCAGCCT GCGAGGCTGG AGGGGCGGCG GGCCCAGCCC GACCCCGGGG 
GCCCCGTCCC CATCGCACCA CGGCAGCGCG GGCGGGGGCG GCGGCTCCTC CCAGGGCCCG 
GCTCTACGCT ATTTCCAGCT GCCCCCGCGG GCGGCCAGCG CAGCCATGTA CGTGCCCGCC 
CGCTCGGGCC GCGGCCGCAA GGGCCCGCTG GTCAAGCAGA CCAAGGTGGA AGGCGAGCCC 
CAGAAGGGCG GCGGCCTCCC GCCCGCGCCG TCGCCCACGT CCCCGGCCTC CCCGCAGCCG 
CCGCCCGCCG TGGCCGCGCC CTCGGAGAAG AACTCCATCC CCATCCCCAC CATCATCATC 
AAGGCCCCGT CCACCAGTAG CAGCGGCCGC AGCAGCCAGG GCAGCAGCAC CGAGGCGGAG 
CCCCCCACCC AGCCGGAGCC CACGGGAGGC GGCGGCGGCG GCGGCTCCTC GCCCAGCCCC 
GCCCCGGCCA TGTCACCCGT GCCCCCGTCC CCCTCGCCCG TGCCCACCCC CGCCTCGCCC 
AGCGGCCCGG CCACGCTGGA CTTCACGAGC CAGTTCGGGG CCGCCCTGGT GGGGGCGGCC 
CGGAGGGAGG GGGGCTGGCA GAATGAGGCG CGCCGGCGCT CCACGCTGTT CCTGTCCACC 
GACGCGGGGG ACGAGGACGG CGGGGACGGC GGGCTGGGCA CAGGGGCGGC CCCGGGCCCG 
CGGCTGCGCC ACTCCAAATC CATCGACGAG GGCATGTTCT CCGCCGAGCC CTACCTCCGA 
CTGGAGTCTG CGGGCAGCGG CGCGGGCTAC GGCGGCTACG GGGCCGGTAG CCGAGCCTAC 
GGGGGTGGCG GGGGCAGCAG CGCCTTCACC AGCTTCCTGC CCCCGCGACC CCTGGTGCAC 
CCGCTGACCG GCAAGGCCCT GGATCCCGCC TCCCCGCTGG GGCTGGCCCT GGCCGCCCGC 
GAGCGAGCGC TGAAGGAGTC CTCGGAGGGC GGCGGGGCCC CCCAGCCGCC TCCCAGGCCC 
CCATCGCCCC GCTACGAGGC CCCGCCGCCC ACCCCGCACC ACCACTCGCC CCACGCCCAC 
CACGAGCCAG TGCTGCGTCT CTGGGGGGCC TCCCCGCCGG ACCCTGCGCG CCGGGAGCTG 
GGGTACAGGG CCGGGCTGGG CAGCCAGGAG AAGTCCCTTC CCGCCAGCCC GCCCGCCGCC 
CGGCGTTCCC TGCTACACCG CCTGCCGCCC ACCGCTCCCG GGGTGGGGCC CCTCCTGCTG 
CAGCTGGGGA CGGAGCCCCC GGCCCCGCAC CCCGGAGTAA GCAAGCCCTG GAGGTCCGCA 
GCCCCCGAAG AACCCGAGCG GCTGCCGCTG CACGTGCGGT TCCTTGAAAA CTGCCAGCCC 
CGGGCCCCTG TGACGAGCGG AAGGGGTCCC CCCTCGGAGG ACGGGCCGGG GGTCCCGCCG 
CCCAGCCCAC GCCGGTCCGT GCCCCCCTCC CCGACCTCCC CGAGGGCCAG CGAAGAGAAC 
GGGCTGCCCC TGCTGGTCCT GCCGCCTCCC GCCCCCTCGG TGGATGTGGA AGATGGCGAA 
TTCCTTTTCG TGGAACCGCT GCCTCCGCCT CTGGAATTCT CCAACAGCTT CGAAAAGCCA 
GAGTCGCCCC TCACGCCTGG GCCTCCCCAC CCGCTGCCCG ACACACCTGC CCCTGCCACC 
CCGTTACCCC CTGTGCCACC CCCGGCTGTG GCCGCAGCCC CTCCCACCCT GGACTCCACC 
GCATCCAGCC TGACATCCTA TGACAGCGAG GTGGCCACCC TGACCCAGGG GGCCTCCGCC 
GCTCCTGGGG ACCCCCATCC ACCAGGCCCG CCTGCCCCAG CAGCACCGGC TCCCGCTGCC 
CCACAGCCTG GCCCGGACCC TCCGCCTGGC ACGGATTCTG GCATCGAGGA GGTGGACAGT 
CGGAGCAGCA GTGACCACCC ACTGGAGACC ATCAGCAGCG CCTCCACGCT GAGCAGCCTA 
TCTGCCGAAG GTGGTGGCAG CGCAGGGGGT GGGGGCGGGG CTGGGGCCGG TGTGGCCAGT 
GGGCCGGAGC TTCTGGACAC CTATGTGGCC TACCTGGACG GCCAGGCCTT TGGGGGCAGC 
AGTACTCCCG GCCCGCCATA CCCTCCTCAG CTCATGACTC CCTCTAAGCT CCGGGGCCGG 
GCGCTAGGAG CCAGCGGAGG CCTGCGGCCT GGCCCCAGCG GGGGACTCCG AGACCCTGTT 
ACCCCCACCA GCCCCACCGT CTCGGTGACA GGGGCTGGAA CCGATGGGCT GCTGGCCCTG 
CGTGCTTGTT CAGGACCCCC CACGGCAGGC GTGGCGGGGG GTCCGGTGGC TGTAGAGCCA 
GAAGTCCCAC CGGTGCCCTT GCCGACGGCC TCCTCTCTGC CCCGGAAGCT GCTGCCCTGG 
GAGGAGGGCC CGGGCCCACC GCCACCACCT CTGCCCGGGC CCTTGGCCCA GCCTCAGGCC 
TCAGCCTTGG CCACAGTAAA AGCCAGCATC ATCAGTGAAC TCAGCTCCAA GCTTCAGCAG 
TTTGGGGGCT CCTCGGCAGC TGGCGGCGCT CTGCCCTGGG CCCGAGGAGG CAGTGGGGGA 
GGCGGAGACA GCCACCACGG GGGAGCCAGC TATGTCCCCG AGAGGACCTC CTCCCTGCAG 
CGGCAGAGAC TCTCCGACGA CTCCCAGTCC TCACTCCTCT CCAAGCCTGT CAGCAGCCTG 
TTTCAGAACT GGCCCAAACC ACCTCTGCCG CCACTCCCCA CCGGAACAGG GGTCTCCCCT 
ACAGCCGCTG CGGCCCCAGG GGCCACCTCA CCCTCAGCCT CCTCCTCCTC CACGTCCACC 
CGCCACCTCC AGGGCGTGGA GTTCGAGATG CGGCCCCCTC TGCTCCGCCG GGCCCCCAGC 
CCCTCGCTGC TGCCCGCCTC GGAGCACAAG GTCAGCCCTG CGCCCAGGCC CTCGTCCCTG 
CCCATCCTGC CTTCCGGACC CCTCTACCCA GGCCTCTTTG ACATCCGTGG CTCCCCAACT 
GGAGGGGCAG GAGGCTCGGC TGACCCCTTC GCCCCAGTCT TTGTGCCGCC ACACCCGGGG 
ATATCCGGGG GGCTCGGGGG AGCCTTGTCA GGGGCCTCGC GCTCCCTCTC ACCGACCCGC 
CTGCTCTCGC TGCCCCCGGA CAAGCCGTTT GGCGCTAAAC CTCTGGGGTT CTGGACCAAG 
TTCGACGTGG CTGATTGGCT GGAGTGGCTG GGTTTGGCGG AGCACCGAGC CCAGTTCCTG 
GACCACGAGA TCGATGGCTC CCACCTGCCC GCCTTGACCA AGGAGGACTA CGTCGATCTA 
GGTGTGACCA GGGTGGGCCA CCGCATGAAC ATCGACCGGG CTCTCAAATT CTTCCTGGAG 
AGGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SHANK1 ( NM_016148.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_057232.2 Homo sapiens SH3 and multiple ankyrin repeat domains 1 (SHANK1), mRNA.

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CloneID	OHu07151
Clone ID Related Accession (Same CDS sequence)	NM_016148.3 , XM_006723233.3 , NM_016148.4 , NM_016148.5
Accession Version	NM_016148.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 6486bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-26
Organism	Homo sapiens(human)
Product	SH3 and multiple ankyrin repeat domains protein 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from EU872208.1, AF163302.1 and AC008743.9. On or before Jun 15, 2017 this sequence version replaced XM_006723233.3, NM_016148.3. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments and RNA-seq data. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## CDS exon combination :: AF163302.1 [ECO:0000331] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## inferred exon combination :: based on alignments, homology ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGACCCACA GCCCCGCGAC AAGCGAGGAC GAGGAACGCC ACAGTGCCAG CGAGTGTCCC 
GAGGGGGGCT CAGAGTCCGA CAGCTCCCCA GACGGGCCAG GTCGAGGCCC CCGGGGGACC 
CGGGGCCAGG GCAGTGGGGC ACCTGGTAGC CTGGCCTCTG TTAGAGGCCT CCAGGGCCGC 
TCAATGTCCG TCCCAGACGA CGCCCACTTC AGCATGATGG TCTTCAGGAT TGGCATCCCG 
GACCTGCACC AGACAAAATG CCTTCGCTTC AACCCCGATG CCACCATCTG GACGGCCAAG 
CAGCAGGTGC TCTGTGCCCT GAGCGAGAGC CTGCAGGATG TGCTCAACTA TGGCCTGTTC 
CAACCGGCCA CCTCCGGCCG CGATGCCAAC TTCCTGGAGG AGGAGAGGCT GCTGCGGGAG 
TACCCCCAGT CCTTTGAGAA GGGGGTCCCC TACCTGGAGT TCCGATACAA GACCCGAGTT 
TACAAACAGA CCAACCTGGA TGAGAAGCAG CTGGCCAAGT TGCACACGAA GACGGGGTTG 
AAGAAGTTCC TGGAGTATGT GCAGCTCGGG ACATCTGACA AGGTGGCGCG GCTGCTGGAC 
AAGGGGCTGG ACCCCAATTA CCATGACTCG GATTCGGGAG AGACCCCCTT GACACTGGCG 
GCCCAGACCG AAGGCTCTGT AGAGGTGATT CGAACCCTGT GCCTGGGCGG GGCCCACATT 
GACTTCCGGG CCCGGGATGG CATGACCGCA CTGCATAAGG CCGCATGCGC CCGACACTGC 
CTGGCACTCA CGGCGCTCCT GGACCTTGGG GGTTCCCCCA ACTACAAGGA CCGTCGGGGG 
CTGACCCCTC TGTTCCACAC GGCCATGGTG GGTGGTGACC CCCGATGCTG CGAGCTGCTC 
CTGTTCAACA GGGCCCAGCT GGGCATAGCT GATGAGAACG GCTGGCAGGA AATCCACCAG 
GCCTGCCAGC GGGGTCACTC TCAGCACCTG GAGCATCTGC TTTTCTACGG GGCTGAGCCT 
GGAGCCCAGA ACGCCTCGGG GAACACGGCT CTGCACATCT GCGCCCTCTA CAACAAGGAG 
ACCTGTGCCA GGATCCTCCT GTATCGAGGT GCCGACAAGG ATGTGAAGAA CAACAACGGA 
CAGACCCCCT TCCAGGTGGC AGTGATTGCT GGGAATTTTG AGCTGGGGGA GCTGATCCGA 
AACCACCGAG AACAGGATGT GGTGCCCTTC CAGGAGTCCC CCAAGTACGC GGCCCGGCGA 
CGGGGGCCCC CAGGCACAGG GCTGACGGTG CCCCCGGCGC TGCTGCGGGC CAACAGTGAC 
ACCAGCATGG CGCTGCCCGA CTGGATGGTG TTCTCCGCCC CGGGGGCCGC GTCCTCTGGG 
GCCCCTGGCC CTACCTCAGG GTCCCAGGGC CAGTCGCAGC CCTCGGCCCC CACCACCAAG 
CTCAGCAGCG GGACCCTCCG AAGTGCCAGC AGCCCCCGGG GTGCCAGGGC CCGCTCTCCA 
TCCCGAGGGA GGCACCCTGA GGACGCCAAG AGGCAGCCCC GAGGCCGGCC CAGCTCCAGC 
GGGACACCCC GGGAAGGGCC AGCCGGGGGC ACGGGGGGCT CAGGGGGCCC CGGGGGCTCC 
CTGGGCAGCC GCGGGAGGCG GAGGAAGCTC TACTCAGCGG TACCCGGACG CTCCTTCATG 
GCTGTGAAGT CCTACCAGGC CCAAGCCGAG GGGGAGATCT CCCTGAGCAA GGGCGAGAAG 
ATCAAAGTAC TTAGCATCGG GGAAGGAGGC TTCTGGGAAG GCCAGGTCAA AGGTCGTGTT 
GGCTGGTTCC CCTCTGACTG CCTGGAAGAA GTGGCGAATC GCTCTCAGGA GAGCAAGCAA 
GAAAGCCGCA GTGACAAGGC AAAGAGACTC TTCCGGCATT ATACCGTGGG CTCCTACGAC 
AGCTTTGATG CCCCAAGCTT AATGGATGGG ATTGGCCCAG GGAGCGATTA CATCATTAAG 
GAGAAGACAG TCTTGCTGCA GAAGAAGGAC AGTGAGGGGT TTGGGTTCGT GCTCCGGGGG 
GCCAAGGCGC AGACCCCCAT CGAGGAGTTC ACCCCCACCC CGGCCTTCCC GGCGCTGCAG 
TACCTGGAGT CGGTGGACGA GGGTGGCGTG GCATGGCGAG CTGGACTGCG AATGGGAGAC 
TTCCTCATCG AGGTGAACGG GCAGAATGTG GTGAAGGTCG GCCACCGACA GGTGGTGAAC 
ATGATCCGCC AAGGGGGCAA CACGCTGATG GTGAAGGTGG TGATGGTCAC CAGGCACCCG 
GACATGGATG AGGCAGTGCA CAAGAAAGCA CCCCAGCAGG CCAAGCGGCT GCCGCCCCCA 
ACCATCTCCC TGCGTTCCAA ATCTATGACC TCAGAGCTGG AGGAGATGGA GTACGAGCAG 
CAGCCGGCGC CGGTGCCCAG CATGGAGAAA AAGCGGACCG TGTATCAGAT GGCTCTCAAC 
AAACTGGACG AAATCCTGGC CGCAGCTCAA CAGACCATCA GTGCAAGCGA AAGCCCTGGT 
CCCGGTGGCC TCGCGTCCCT GGGCAAACAC CGACCCAAAG GTTTCTTTGC CACTGAGTCG 
AGCTTCGATC CCCACCACCG TGCCCAGCCA AGTTACGAGC GTCCTTCTTT CCTGCCTCCA 
GGACCTGGGT TGATGCTCCG GCAAAAATCT ATCGGTGCGG CAGAAGATGA CAGACCTTAC 
CTAGCACCCC CAGCCATGAA ATTCAGCCGC AGCCTGTCTG TGCCTGGTTC GGAGGACATT 
CCCCCGCCAC CCACCACGTC CCCACCGGAG CCTCCCTACA GCACACCTCC AGTCCCCTCC 
TCCTCAGGGC GCCTCACCCC CTCCCCTCGG GGAGGGCCCT TCAACCCTGG CTCTGGTGGC 
CCCCTCCCCG CCTCCTCCCC TGCATCCTTT GACGGGCCCT CCCCTCCCGA CACTCGCGTG 
GGGAGCCGCG AGAAGAGCCT GTACCACAGT GGGCCCCTGC CCCCGGCCCA CCACCACCCG 
CCCCACCACC ACCACCACCA CGCCCCGCCC CCTCAGCCCC ACCACCACCA CGCCCACCCC 
CCTCATCCTC CCGAGATGGA GACAGGCGGC TCTCCCGACG ACCCTCCACC CCGCCTGGCT 
CTGGGGCCCC AGCCCAGCCT GCGAGGCTGG AGGGGCGGCG GGCCCAGCCC GACCCCGGGG 
GCCCCGTCCC CATCGCACCA CGGCAGCGCG GGCGGGGGCG GCGGCTCCTC CCAGGGCCCG 
GCTCTACGCT ATTTCCAGCT GCCCCCGCGG GCGGCCAGCG CAGCCATGTA CGTGCCCGCC 
CGCTCGGGCC GCGGCCGCAA GGGCCCGCTG GTCAAGCAGA CCAAGGTGGA AGGCGAGCCC 
CAGAAGGGCG GCGGCCTCCC GCCCGCGCCG TCGCCCACGT CCCCGGCCTC CCCGCAGCCG 
CCGCCCGCCG TGGCCGCGCC CTCGGAGAAG AACTCCATCC CCATCCCCAC CATCATCATC 
AAGGCCCCGT CCACCAGTAG CAGCGGCCGC AGCAGCCAGG GCAGCAGCAC CGAGGCGGAG 
CCCCCCACCC AGCCGGAGCC CACGGGAGGC GGCGGCGGCG GCGGCTCCTC GCCCAGCCCC 
GCCCCGGCCA TGTCACCCGT GCCCCCGTCC CCCTCGCCCG TGCCCACCCC CGCCTCGCCC 
AGCGGCCCGG CCACGCTGGA CTTCACGAGC CAGTTCGGGG CCGCCCTGGT GGGGGCGGCC 
CGGAGGGAGG GGGGCTGGCA GAATGAGGCG CGCCGGCGCT CCACGCTGTT CCTGTCCACC 
GACGCGGGGG ACGAGGACGG CGGGGACGGC GGGCTGGGCA CAGGGGCGGC CCCGGGCCCG 
CGGCTGCGCC ACTCCAAATC CATCGACGAG GGCATGTTCT CCGCCGAGCC CTACCTCCGA 
CTGGAGTCTG CGGGCAGCGG CGCGGGCTAC GGCGGCTACG GGGCCGGTAG CCGAGCCTAC 
GGGGGTGGCG GGGGCAGCAG CGCCTTCACC AGCTTCCTGC CCCCGCGACC CCTGGTGCAC 
CCGCTGACCG GCAAGGCCCT GGATCCCGCC TCCCCGCTGG GGCTGGCCCT GGCCGCCCGC 
GAGCGAGCGC TGAAGGAGTC CTCGGAGGGC GGCGGGGCCC CCCAGCCGCC TCCCAGGCCC 
CCATCGCCCC GCTACGAGGC CCCGCCGCCC ACCCCGCACC ACCACTCGCC CCACGCCCAC 
CACGAGCCAG TGCTGCGTCT CTGGGGGGCC TCCCCGCCGG ACCCTGCGCG CCGGGAGCTG 
GGGTACAGGG CCGGGCTGGG CAGCCAGGAG AAGTCCCTTC CCGCCAGCCC GCCCGCCGCC 
CGGCGTTCCC TGCTACACCG CCTGCCGCCC ACCGCTCCCG GGGTGGGGCC CCTCCTGCTG 
CAGCTGGGGA CGGAGCCCCC GGCCCCGCAC CCCGGAGTAA GCAAGCCCTG GAGGTCCGCA 
GCCCCCGAAG AACCCGAGCG GCTGCCGCTG CACGTGCGGT TCCTTGAAAA CTGCCAGCCC 
CGGGCCCCTG TGACGAGCGG AAGGGGTCCC CCCTCGGAGG ACGGGCCGGG GGTCCCGCCG 
CCCAGCCCAC GCCGGTCCGT GCCCCCCTCC CCGACCTCCC CGAGGGCCAG CGAAGAGAAC 
GGGCTGCCCC TGCTGGTCCT GCCGCCTCCC GCCCCCTCGG TGGATGTGGA AGATGGCGAA 
TTCCTTTTCG TGGAACCGCT GCCTCCGCCT CTGGAATTCT CCAACAGCTT CGAAAAGCCA 
GAGTCGCCCC TCACGCCTGG GCCTCCCCAC CCGCTGCCCG ACACACCTGC CCCTGCCACC 
CCGTTACCCC CTGTGCCACC CCCGGCTGTG GCCGCAGCCC CTCCCACCCT GGACTCCACC 
GCATCCAGCC TGACATCCTA TGACAGCGAG GTGGCCACCC TGACCCAGGG GGCCTCCGCC 
GCTCCTGGGG ACCCCCATCC ACCAGGCCCG CCTGCCCCAG CAGCACCGGC TCCCGCTGCC 
CCACAGCCTG GCCCGGACCC TCCGCCTGGC ACGGATTCTG GCATCGAGGA GGTGGACAGT 
CGGAGCAGCA GTGACCACCC ACTGGAGACC ATCAGCAGCG CCTCCACGCT GAGCAGCCTA 
TCTGCCGAAG GTGGTGGCAG CGCAGGGGGT GGGGGCGGGG CTGGGGCCGG TGTGGCCAGT 
GGGCCGGAGC TTCTGGACAC CTATGTGGCC TACCTGGACG GCCAGGCCTT TGGGGGCAGC 
AGTACTCCCG GCCCGCCATA CCCTCCTCAG CTCATGACTC CCTCTAAGCT CCGGGGCCGG 
GCGCTAGGAG CCAGCGGAGG CCTGCGGCCT GGCCCCAGCG GGGGACTCCG AGACCCTGTT 
ACCCCCACCA GCCCCACCGT CTCGGTGACA GGGGCTGGAA CCGATGGGCT GCTGGCCCTG 
CGTGCTTGTT CAGGACCCCC CACGGCAGGC GTGGCGGGGG GTCCGGTGGC TGTAGAGCCA 
GAAGTCCCAC CGGTGCCCTT GCCGACGGCC TCCTCTCTGC CCCGGAAGCT GCTGCCCTGG 
GAGGAGGGCC CGGGCCCACC GCCACCACCT CTGCCCGGGC CCTTGGCCCA GCCTCAGGCC 
TCAGCCTTGG CCACAGTAAA AGCCAGCATC ATCAGTGAAC TCAGCTCCAA GCTTCAGCAG 
TTTGGGGGCT CCTCGGCAGC TGGCGGCGCT CTGCCCTGGG CCCGAGGAGG CAGTGGGGGA 
GGCGGAGACA GCCACCACGG GGGAGCCAGC TATGTCCCCG AGAGGACCTC CTCCCTGCAG 
CGGCAGAGAC TCTCCGACGA CTCCCAGTCC TCACTCCTCT CCAAGCCTGT CAGCAGCCTG 
TTTCAGAACT GGCCCAAACC ACCTCTGCCG CCACTCCCCA CCGGAACAGG GGTCTCCCCT 
ACAGCCGCTG CGGCCCCAGG GGCCACCTCA CCCTCAGCCT CCTCCTCCTC CACGTCCACC 
CGCCACCTCC AGGGCGTGGA GTTCGAGATG CGGCCCCCTC TGCTCCGCCG GGCCCCCAGC 
CCCTCGCTGC TGCCCGCCTC GGAGCACAAG GTCAGCCCTG CGCCCAGGCC CTCGTCCCTG 
CCCATCCTGC CTTCCGGACC CCTCTACCCA GGCCTCTTTG ACATCCGTGG CTCCCCAACT 
GGAGGGGCAG GAGGCTCGGC TGACCCCTTC GCCCCAGTCT TTGTGCCGCC ACACCCGGGG 
ATATCCGGGG GGCTCGGGGG AGCCTTGTCA GGGGCCTCGC GCTCCCTCTC ACCGACCCGC 
CTGCTCTCGC TGCCCCCGGA CAAGCCGTTT GGCGCTAAAC CTCTGGGGTT CTGGACCAAG 
TTCGACGTGG CTGATTGGCT GGAGTGGCTG GGTTTGGCGG AGCACCGAGC CCAGTTCCTG 
GACCACGAGA TCGATGGCTC CCACCTGCCC GCCTTGACCA AGGAGGACTA CGTCGATCTA 
GGTGTGACCA GGGTGGGCCA CCGCATGAAC ATCGACCGGG CTCTCAAATT CTTCCTGGAG 
AGGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_057232.2
CDS	422..6907
Translation	MTHSPATSEDEERHSASECPEGGSESDSSPDGPGRGPRGTRGQGSGAPGSLASVRGLQGRSMSVPDDAHFSMMVFRIGIPDLHQTKCLRFNPDATIWTAKQQVLCALSESLQDVLNYGLFQPATSGRDANFLEEERLLREYPQSFEKGVPYLEFRYKTRVYKQTNLDEKQLAKLHTKTGLKKFLEYVQLGTSDKVARLLDKGLDPNYHDSDSGETPLTLAAQTEGSVEVIRTLCLGGAHIDFRARDGMTALHKAACARHCLALTALLDLGGSPNYKDRRGLTPLFHTAMVGGDPRCCELLLFNRAQLGIADENGWQEIHQACQRGHSQHLEHLLFYGAEPGAQNASGNTALHICALYNKETCARILLYRGADKDVKNNNGQTPFQVAVIAGNFELGELIRNHREQDVVPFQESPKYAARRRGPPGTGLTVPPALLRANSDTSMALPDWMVFSAPGAASSGAPGPTSGSQGQSQPSAPTTKLSSGTLRSASSPRGARARSPSRGRHPEDAKRQPRGRPSSSGTPREGPAGGTGGSGGPGGSLGSRGRRRKLYSAVPGRSFMAVKSYQAQAEGEISLSKGEKIKVLSIGEGGFWEGQVKGRVGWFPSDCLEEVANRSQESKQESRSDKAKRLFRHYTVGSYDSFDAPSLMDGIGPGSDYIIKEKTVLLQKKDSEGFGFVLRGAKAQTPIEEFTPTPAFPALQYLESVDEGGVAWRAGLRMGDFLIEVNGQNVVKVGHRQVVNMIRQGGNTLMVKVVMVTRHPDMDEAVHKKAPQQAKRLPPPTISLRSKSMTSELEEMEYEQQPAPVPSMEKKRTVYQMALNKLDEILAAAQQTISASESPGPGGLASLGKHRPKGFFATESSFDPHHRAQPSYERPSFLPPGPGLMLRQKSIGAAEDDRPYLAPPAMKFSRSLSVPGSEDIPPPPTTSPPEPPYSTPPVPSSSGRLTPSPRGGPFNPGSGGPLPASSPASFDGPSPPDTRVGSREKSLYHSGPLPPAHHHPPHHHHHHAPPPQPHHHHAHPPHPPEMETGGSPDDPPPRLALGPQPSLRGWRGGGPSPTPGAPSPSHHGSAGGGGGSSQGPALRYFQLPPRAASAAMYVPARSGRGRKGPLVKQTKVEGEPQKGGGLPPAPSPTSPASPQPPPAVAAPSEKNSIPIPTIIIKAPSTSSSGRSSQGSSTEAEPPTQPEPTGGGGGGGSSPSPAPAMSPVPPSPSPVPTPASPSGPATLDFTSQFGAALVGAARREGGWQNEARRRSTLFLSTDAGDEDGGDGGLGTGAAPGPRLRHSKSIDEGMFSAEPYLRLESAGSGAGYGGYGAGSRAYGGGGGSSAFTSFLPPRPLVHPLTGKALDPASPLGLALAARERALKESSEGGGAPQPPPRPPSPRYEAPPPTPHHHSPHAHHEPVLRLWGASPPDPARRELGYRAGLGSQEKSLPASPPAARRSLLHRLPPTAPGVGPLLLQLGTEPPAPHPGVSKPWRSAAPEEPERLPLHVRFLENCQPRAPVTSGRGPPSEDGPGVPPPSPRRSVPPSPTSPRASEENGLPLLVLPPPAPSVDVEDGEFLFVEPLPPPLEFSNSFEKPESPLTPGPPHPLPDTPAPATPLPPVPPPAVAAAPPTLDSTASSLTSYDSEVATLTQGASAAPGDPHPPGPPAPAAPAPAAPQPGPDPPPGTDSGIEEVDSRSSSDHPLETISSASTLSSLSAEGGGSAGGGGGAGAGVASGPELLDTYVAYLDGQAFGGSSTPGPPYPPQLMTPSKLRGRALGASGGLRPGPSGGLRDPVTPTSPTVSVTGAGTDGLLALRACSGPPTAGVAGGPVAVEPEVPPVPLPTASSLPRKLLPWEEGPGPPPPPLPGPLAQPQASALATVKASIISELSSKLQQFGGSSAAGGALPWARGGSGGGGDSHHGGASYVPERTSSLQRQRLSDDSQSSLLSKPVSSLFQNWPKPPLPPLPTGTGVSPTAAAAPGATSPSASSSSTSTRHLQGVEFEMRPPLLRRAPSPSLLPASEHKVSPAPRPSSLPILPSGPLYPGLFDIRGSPTGGAGGSADPFAPVFVPPHPGISGGLGGALSGASRSLSPTRLLSLPPDKPFGAKPLGFWTKFDVADWLEWLGLAEHRAQFLDHEIDGSHLPALTKEDYVDLGVTRVGHRMNIDRALKFFLER

Target ORF information:

RefSeq Version	NM_016148.4
Organism	Homo sapiens(human)
Definition	Homo sapiens SH3 and multiple ankyrin repeat domains 1 (SHANK1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_016148.4

ORF Insert Sequence:

ATGACCCACA GCCCCGCGAC AAGCGAGGAC GAGGAACGCC ACAGTGCCAG CGAGTGTCCC 
GAGGGGGGCT CAGAGTCCGA CAGCTCCCCA GACGGGCCAG GTCGAGGCCC CCGGGGGACC 
CGGGGCCAGG GCAGTGGGGC ACCTGGTAGC CTGGCCTCTG TTAGAGGCCT CCAGGGCCGC 
TCAATGTCCG TCCCAGACGA CGCCCACTTC AGCATGATGG TCTTCAGGAT TGGCATCCCG 
GACCTGCACC AGACAAAATG CCTTCGCTTC AACCCCGATG CCACCATCTG GACGGCCAAG 
CAGCAGGTGC TCTGTGCCCT GAGCGAGAGC CTGCAGGATG TGCTCAACTA TGGCCTGTTC 
CAACCGGCCA CCTCCGGCCG CGATGCCAAC TTCCTGGAGG AGGAGAGGCT GCTGCGGGAG 
TACCCCCAGT CCTTTGAGAA GGGGGTCCCC TACCTGGAGT TCCGATACAA GACCCGAGTT 
TACAAACAGA CCAACCTGGA TGAGAAGCAG CTGGCCAAGT TGCACACGAA GACGGGGTTG 
AAGAAGTTCC TGGAGTATGT GCAGCTCGGG ACATCTGACA AGGTGGCGCG GCTGCTGGAC 
AAGGGGCTGG ACCCCAATTA CCATGACTCG GATTCGGGAG AGACCCCCTT GACACTGGCG 
GCCCAGACCG AAGGCTCTGT AGAGGTGATT CGAACCCTGT GCCTGGGCGG GGCCCACATT 
GACTTCCGGG CCCGGGATGG CATGACCGCA CTGCATAAGG CCGCATGCGC CCGACACTGC 
CTGGCACTCA CGGCGCTCCT GGACCTTGGG GGTTCCCCCA ACTACAAGGA CCGTCGGGGG 
CTGACCCCTC TGTTCCACAC GGCCATGGTG GGTGGTGACC CCCGATGCTG CGAGCTGCTC 
CTGTTCAACA GGGCCCAGCT GGGCATAGCT GATGAGAACG GCTGGCAGGA AATCCACCAG 
GCCTGCCAGC GGGGTCACTC TCAGCACCTG GAGCATCTGC TTTTCTACGG GGCTGAGCCT 
GGAGCCCAGA ACGCCTCGGG GAACACGGCT CTGCACATCT GCGCCCTCTA CAACAAGGAG 
ACCTGTGCCA GGATCCTCCT GTATCGAGGT GCCGACAAGG ATGTGAAGAA CAACAACGGA 
CAGACCCCCT TCCAGGTGGC AGTGATTGCT GGGAATTTTG AGCTGGGGGA GCTGATCCGA 
AACCACCGAG AACAGGATGT GGTGCCCTTC CAGGAGTCCC CCAAGTACGC GGCCCGGCGA 
CGGGGGCCCC CAGGCACAGG GCTGACGGTG CCCCCGGCGC TGCTGCGGGC CAACAGTGAC 
ACCAGCATGG CGCTGCCCGA CTGGATGGTG TTCTCCGCCC CGGGGGCCGC GTCCTCTGGG 
GCCCCTGGCC CTACCTCAGG GTCCCAGGGC CAGTCGCAGC CCTCGGCCCC CACCACCAAG 
CTCAGCAGCG GGACCCTCCG AAGTGCCAGC AGCCCCCGGG GTGCCAGGGC CCGCTCTCCA 
TCCCGAGGGA GGCACCCTGA GGACGCCAAG AGGCAGCCCC GAGGCCGGCC CAGCTCCAGC 
GGGACACCCC GGGAAGGGCC AGCCGGGGGC ACGGGGGGCT CAGGGGGCCC CGGGGGCTCC 
CTGGGCAGCC GCGGGAGGCG GAGGAAGCTC TACTCAGCGG TACCCGGACG CTCCTTCATG 
GCTGTGAAGT CCTACCAGGC CCAAGCCGAG GGGGAGATCT CCCTGAGCAA GGGCGAGAAG 
ATCAAAGTAC TTAGCATCGG GGAAGGAGGC TTCTGGGAAG GCCAGGTCAA AGGTCGTGTT 
GGCTGGTTCC CCTCTGACTG CCTGGAAGAA GTGGCGAATC GCTCTCAGGA GAGCAAGCAA 
GAAAGCCGCA GTGACAAGGC AAAGAGACTC TTCCGGCATT ATACCGTGGG CTCCTACGAC 
AGCTTTGATG CCCCAAGCTT AATGGATGGG ATTGGCCCAG GGAGCGATTA CATCATTAAG 
GAGAAGACAG TCTTGCTGCA GAAGAAGGAC AGTGAGGGGT TTGGGTTCGT GCTCCGGGGG 
GCCAAGGCGC AGACCCCCAT CGAGGAGTTC ACCCCCACCC CGGCCTTCCC GGCGCTGCAG 
TACCTGGAGT CGGTGGACGA GGGTGGCGTG GCATGGCGAG CTGGACTGCG AATGGGAGAC 
TTCCTCATCG AGGTGAACGG GCAGAATGTG GTGAAGGTCG GCCACCGACA GGTGGTGAAC 
ATGATCCGCC AAGGGGGCAA CACGCTGATG GTGAAGGTGG TGATGGTCAC CAGGCACCCG 
GACATGGATG AGGCAGTGCA CAAGAAAGCA CCCCAGCAGG CCAAGCGGCT GCCGCCCCCA 
ACCATCTCCC TGCGTTCCAA ATCTATGACC TCAGAGCTGG AGGAGATGGA GTACGAGCAG 
CAGCCGGCGC CGGTGCCCAG CATGGAGAAA AAGCGGACCG TGTATCAGAT GGCTCTCAAC 
AAACTGGACG AAATCCTGGC CGCAGCTCAA CAGACCATCA GTGCAAGCGA AAGCCCTGGT 
CCCGGTGGCC TCGCGTCCCT GGGCAAACAC CGACCCAAAG GTTTCTTTGC CACTGAGTCG 
AGCTTCGATC CCCACCACCG TGCCCAGCCA AGTTACGAGC GTCCTTCTTT CCTGCCTCCA 
GGACCTGGGT TGATGCTCCG GCAAAAATCT ATCGGTGCGG CAGAAGATGA CAGACCTTAC 
CTAGCACCCC CAGCCATGAA ATTCAGCCGC AGCCTGTCTG TGCCTGGTTC GGAGGACATT 
CCCCCGCCAC CCACCACGTC CCCACCGGAG CCTCCCTACA GCACACCTCC AGTCCCCTCC 
TCCTCAGGGC GCCTCACCCC CTCCCCTCGG GGAGGGCCCT TCAACCCTGG CTCTGGTGGC 
CCCCTCCCCG CCTCCTCCCC TGCATCCTTT GACGGGCCCT CCCCTCCCGA CACTCGCGTG 
GGGAGCCGCG AGAAGAGCCT GTACCACAGT GGGCCCCTGC CCCCGGCCCA CCACCACCCG 
CCCCACCACC ACCACCACCA CGCCCCGCCC CCTCAGCCCC ACCACCACCA CGCCCACCCC 
CCTCATCCTC CCGAGATGGA GACAGGCGGC TCTCCCGACG ACCCTCCACC CCGCCTGGCT 
CTGGGGCCCC AGCCCAGCCT GCGAGGCTGG AGGGGCGGCG GGCCCAGCCC GACCCCGGGG 
GCCCCGTCCC CATCGCACCA CGGCAGCGCG GGCGGGGGCG GCGGCTCCTC CCAGGGCCCG 
GCTCTACGCT ATTTCCAGCT GCCCCCGCGG GCGGCCAGCG CAGCCATGTA CGTGCCCGCC 
CGCTCGGGCC GCGGCCGCAA GGGCCCGCTG GTCAAGCAGA CCAAGGTGGA AGGCGAGCCC 
CAGAAGGGCG GCGGCCTCCC GCCCGCGCCG TCGCCCACGT CCCCGGCCTC CCCGCAGCCG 
CCGCCCGCCG TGGCCGCGCC CTCGGAGAAG AACTCCATCC CCATCCCCAC CATCATCATC 
AAGGCCCCGT CCACCAGTAG CAGCGGCCGC AGCAGCCAGG GCAGCAGCAC CGAGGCGGAG 
CCCCCCACCC AGCCGGAGCC CACGGGAGGC GGCGGCGGCG GCGGCTCCTC GCCCAGCCCC 
GCCCCGGCCA TGTCACCCGT GCCCCCGTCC CCCTCGCCCG TGCCCACCCC CGCCTCGCCC 
AGCGGCCCGG CCACGCTGGA CTTCACGAGC CAGTTCGGGG CCGCCCTGGT GGGGGCGGCC 
CGGAGGGAGG GGGGCTGGCA GAATGAGGCG CGCCGGCGCT CCACGCTGTT CCTGTCCACC 
GACGCGGGGG ACGAGGACGG CGGGGACGGC GGGCTGGGCA CAGGGGCGGC CCCGGGCCCG 
CGGCTGCGCC ACTCCAAATC CATCGACGAG GGCATGTTCT CCGCCGAGCC CTACCTCCGA 
CTGGAGTCTG CGGGCAGCGG CGCGGGCTAC GGCGGCTACG GGGCCGGTAG CCGAGCCTAC 
GGGGGTGGCG GGGGCAGCAG CGCCTTCACC AGCTTCCTGC CCCCGCGACC CCTGGTGCAC 
CCGCTGACCG GCAAGGCCCT GGATCCCGCC TCCCCGCTGG GGCTGGCCCT GGCCGCCCGC 
GAGCGAGCGC TGAAGGAGTC CTCGGAGGGC GGCGGGGCCC CCCAGCCGCC TCCCAGGCCC 
CCATCGCCCC GCTACGAGGC CCCGCCGCCC ACCCCGCACC ACCACTCGCC CCACGCCCAC 
CACGAGCCAG TGCTGCGTCT CTGGGGGGCC TCCCCGCCGG ACCCTGCGCG CCGGGAGCTG 
GGGTACAGGG CCGGGCTGGG CAGCCAGGAG AAGTCCCTTC CCGCCAGCCC GCCCGCCGCC 
CGGCGTTCCC TGCTACACCG CCTGCCGCCC ACCGCTCCCG GGGTGGGGCC CCTCCTGCTG 
CAGCTGGGGA CGGAGCCCCC GGCCCCGCAC CCCGGAGTAA GCAAGCCCTG GAGGTCCGCA 
GCCCCCGAAG AACCCGAGCG GCTGCCGCTG CACGTGCGGT TCCTTGAAAA CTGCCAGCCC 
CGGGCCCCTG TGACGAGCGG AAGGGGTCCC CCCTCGGAGG ACGGGCCGGG GGTCCCGCCG 
CCCAGCCCAC GCCGGTCCGT GCCCCCCTCC CCGACCTCCC CGAGGGCCAG CGAAGAGAAC 
GGGCTGCCCC TGCTGGTCCT GCCGCCTCCC GCCCCCTCGG TGGATGTGGA AGATGGCGAA 
TTCCTTTTCG TGGAACCGCT GCCTCCGCCT CTGGAATTCT CCAACAGCTT CGAAAAGCCA 
GAGTCGCCCC TCACGCCTGG GCCTCCCCAC CCGCTGCCCG ACACACCTGC CCCTGCCACC 
CCGTTACCCC CTGTGCCACC CCCGGCTGTG GCCGCAGCCC CTCCCACCCT GGACTCCACC 
GCATCCAGCC TGACATCCTA TGACAGCGAG GTGGCCACCC TGACCCAGGG GGCCTCCGCC 
GCTCCTGGGG ACCCCCATCC ACCAGGCCCG CCTGCCCCAG CAGCACCGGC TCCCGCTGCC 
CCACAGCCTG GCCCGGACCC TCCGCCTGGC ACGGATTCTG GCATCGAGGA GGTGGACAGT 
CGGAGCAGCA GTGACCACCC ACTGGAGACC ATCAGCAGCG CCTCCACGCT GAGCAGCCTA 
TCTGCCGAAG GTGGTGGCAG CGCAGGGGGT GGGGGCGGGG CTGGGGCCGG TGTGGCCAGT 
GGGCCGGAGC TTCTGGACAC CTATGTGGCC TACCTGGACG GCCAGGCCTT TGGGGGCAGC 
AGTACTCCCG GCCCGCCATA CCCTCCTCAG CTCATGACTC CCTCTAAGCT CCGGGGCCGG 
GCGCTAGGAG CCAGCGGAGG CCTGCGGCCT GGCCCCAGCG GGGGACTCCG AGACCCTGTT 
ACCCCCACCA GCCCCACCGT CTCGGTGACA GGGGCTGGAA CCGATGGGCT GCTGGCCCTG 
CGTGCTTGTT CAGGACCCCC CACGGCAGGC GTGGCGGGGG GTCCGGTGGC TGTAGAGCCA 
GAAGTCCCAC CGGTGCCCTT GCCGACGGCC TCCTCTCTGC CCCGGAAGCT GCTGCCCTGG 
GAGGAGGGCC CGGGCCCACC GCCACCACCT CTGCCCGGGC CCTTGGCCCA GCCTCAGGCC 
TCAGCCTTGG CCACAGTAAA AGCCAGCATC ATCAGTGAAC TCAGCTCCAA GCTTCAGCAG 
TTTGGGGGCT CCTCGGCAGC TGGCGGCGCT CTGCCCTGGG CCCGAGGAGG CAGTGGGGGA 
GGCGGAGACA GCCACCACGG GGGAGCCAGC TATGTCCCCG AGAGGACCTC CTCCCTGCAG 
CGGCAGAGAC TCTCCGACGA CTCCCAGTCC TCACTCCTCT CCAAGCCTGT CAGCAGCCTG 
TTTCAGAACT GGCCCAAACC ACCTCTGCCG CCACTCCCCA CCGGAACAGG GGTCTCCCCT 
ACAGCCGCTG CGGCCCCAGG GGCCACCTCA CCCTCAGCCT CCTCCTCCTC CACGTCCACC 
CGCCACCTCC AGGGCGTGGA GTTCGAGATG CGGCCCCCTC TGCTCCGCCG GGCCCCCAGC 
CCCTCGCTGC TGCCCGCCTC GGAGCACAAG GTCAGCCCTG CGCCCAGGCC CTCGTCCCTG 
CCCATCCTGC CTTCCGGACC CCTCTACCCA GGCCTCTTTG ACATCCGTGG CTCCCCAACT 
GGAGGGGCAG GAGGCTCGGC TGACCCCTTC GCCCCAGTCT TTGTGCCGCC ACACCCGGGG 
ATATCCGGGG GGCTCGGGGG AGCCTTGTCA GGGGCCTCGC GCTCCCTCTC ACCGACCCGC 
CTGCTCTCGC TGCCCCCGGA CAAGCCGTTT GGCGCTAAAC CTCTGGGGTT CTGGACCAAG 
TTCGACGTGG CTGATTGGCT GGAGTGGCTG GGTTTGGCGG AGCACCGAGC CCAGTTCCTG 
GACCACGAGA TCGATGGCTC CCACCTGCCC GCCTTGACCA AGGAGGACTA CGTCGATCTA 
GGTGTGACCA GGGTGGGCCA CCGCATGAAC ATCGACCGGG CTCTCAAATT CTTCCTGGAG 
AGGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SHANK1 ( NM_016148.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_057232.2 Homo sapiens SH3 and multiple ankyrin repeat domains 1 (SHANK1), mRNA.

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CloneID	OHu07151
Clone ID Related Accession (Same CDS sequence)	NM_016148.3 , XM_006723233.3 , NM_016148.4 , NM_016148.5
Accession Version	NM_016148.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 6486bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-28
Organism	Homo sapiens(human)
Product	SH3 and multiple ankyrin repeat domains protein 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC010325.7, EU872208.1, AF163302.1 and AC008743.9. On Jun 2, 2019 this sequence version replaced NM_016148.4. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments and RNA-seq data. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## CDS exon combination :: AF163302.1 [ECO:0000331] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## inferred exon combination :: based on alignments, homology RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGACCCACA GCCCCGCGAC AAGCGAGGAC GAGGAACGCC ACAGTGCCAG CGAGTGTCCC 
GAGGGGGGCT CAGAGTCCGA CAGCTCCCCA GACGGGCCAG GTCGAGGCCC CCGGGGGACC 
CGGGGCCAGG GCAGTGGGGC ACCTGGTAGC CTGGCCTCTG TTAGAGGCCT CCAGGGCCGC 
TCAATGTCCG TCCCAGACGA CGCCCACTTC AGCATGATGG TCTTCAGGAT TGGCATCCCG 
GACCTGCACC AGACAAAATG CCTTCGCTTC AACCCCGATG CCACCATCTG GACGGCCAAG 
CAGCAGGTGC TCTGTGCCCT GAGCGAGAGC CTGCAGGATG TGCTCAACTA TGGCCTGTTC 
CAACCGGCCA CCTCCGGCCG CGATGCCAAC TTCCTGGAGG AGGAGAGGCT GCTGCGGGAG 
TACCCCCAGT CCTTTGAGAA GGGGGTCCCC TACCTGGAGT TCCGATACAA GACCCGAGTT 
TACAAACAGA CCAACCTGGA TGAGAAGCAG CTGGCCAAGT TGCACACGAA GACGGGGTTG 
AAGAAGTTCC TGGAGTATGT GCAGCTCGGG ACATCTGACA AGGTGGCGCG GCTGCTGGAC 
AAGGGGCTGG ACCCCAATTA CCATGACTCG GATTCGGGAG AGACCCCCTT GACACTGGCG 
GCCCAGACCG AAGGCTCTGT AGAGGTGATT CGAACCCTGT GCCTGGGCGG GGCCCACATT 
GACTTCCGGG CCCGGGATGG CATGACCGCA CTGCATAAGG CCGCATGCGC CCGACACTGC 
CTGGCACTCA CGGCGCTCCT GGACCTTGGG GGTTCCCCCA ACTACAAGGA CCGTCGGGGG 
CTGACCCCTC TGTTCCACAC GGCCATGGTG GGTGGTGACC CCCGATGCTG CGAGCTGCTC 
CTGTTCAACA GGGCCCAGCT GGGCATAGCT GATGAGAACG GCTGGCAGGA AATCCACCAG 
GCCTGCCAGC GGGGTCACTC TCAGCACCTG GAGCATCTGC TTTTCTACGG GGCTGAGCCT 
GGAGCCCAGA ACGCCTCGGG GAACACGGCT CTGCACATCT GCGCCCTCTA CAACAAGGAG 
ACCTGTGCCA GGATCCTCCT GTATCGAGGT GCCGACAAGG ATGTGAAGAA CAACAACGGA 
CAGACCCCCT TCCAGGTGGC AGTGATTGCT GGGAATTTTG AGCTGGGGGA GCTGATCCGA 
AACCACCGAG AACAGGATGT GGTGCCCTTC CAGGAGTCCC CCAAGTACGC GGCCCGGCGA 
CGGGGGCCCC CAGGCACAGG GCTGACGGTG CCCCCGGCGC TGCTGCGGGC CAACAGTGAC 
ACCAGCATGG CGCTGCCCGA CTGGATGGTG TTCTCCGCCC CGGGGGCCGC GTCCTCTGGG 
GCCCCTGGCC CTACCTCAGG GTCCCAGGGC CAGTCGCAGC CCTCGGCCCC CACCACCAAG 
CTCAGCAGCG GGACCCTCCG AAGTGCCAGC AGCCCCCGGG GTGCCAGGGC CCGCTCTCCA 
TCCCGAGGGA GGCACCCTGA GGACGCCAAG AGGCAGCCCC GAGGCCGGCC CAGCTCCAGC 
GGGACACCCC GGGAAGGGCC AGCCGGGGGC ACGGGGGGCT CAGGGGGCCC CGGGGGCTCC 
CTGGGCAGCC GCGGGAGGCG GAGGAAGCTC TACTCAGCGG TACCCGGACG CTCCTTCATG 
GCTGTGAAGT CCTACCAGGC CCAAGCCGAG GGGGAGATCT CCCTGAGCAA GGGCGAGAAG 
ATCAAAGTAC TTAGCATCGG GGAAGGAGGC TTCTGGGAAG GCCAGGTCAA AGGTCGTGTT 
GGCTGGTTCC CCTCTGACTG CCTGGAAGAA GTGGCGAATC GCTCTCAGGA GAGCAAGCAA 
GAAAGCCGCA GTGACAAGGC AAAGAGACTC TTCCGGCATT ATACCGTGGG CTCCTACGAC 
AGCTTTGATG CCCCAAGCTT AATGGATGGG ATTGGCCCAG GGAGCGATTA CATCATTAAG 
GAGAAGACAG TCTTGCTGCA GAAGAAGGAC AGTGAGGGGT TTGGGTTCGT GCTCCGGGGG 
GCCAAGGCGC AGACCCCCAT CGAGGAGTTC ACCCCCACCC CGGCCTTCCC GGCGCTGCAG 
TACCTGGAGT CGGTGGACGA GGGTGGCGTG GCATGGCGAG CTGGACTGCG AATGGGAGAC 
TTCCTCATCG AGGTGAACGG GCAGAATGTG GTGAAGGTCG GCCACCGACA GGTGGTGAAC 
ATGATCCGCC AAGGGGGCAA CACGCTGATG GTGAAGGTGG TGATGGTCAC CAGGCACCCG 
GACATGGATG AGGCAGTGCA CAAGAAAGCA CCCCAGCAGG CCAAGCGGCT GCCGCCCCCA 
ACCATCTCCC TGCGTTCCAA ATCTATGACC TCAGAGCTGG AGGAGATGGA GTACGAGCAG 
CAGCCGGCGC CGGTGCCCAG CATGGAGAAA AAGCGGACCG TGTATCAGAT GGCTCTCAAC 
AAACTGGACG AAATCCTGGC CGCAGCTCAA CAGACCATCA GTGCAAGCGA AAGCCCTGGT 
CCCGGTGGCC TCGCGTCCCT GGGCAAACAC CGACCCAAAG GTTTCTTTGC CACTGAGTCG 
AGCTTCGATC CCCACCACCG TGCCCAGCCA AGTTACGAGC GTCCTTCTTT CCTGCCTCCA 
GGACCTGGGT TGATGCTCCG GCAAAAATCT ATCGGTGCGG CAGAAGATGA CAGACCTTAC 
CTAGCACCCC CAGCCATGAA ATTCAGCCGC AGCCTGTCTG TGCCTGGTTC GGAGGACATT 
CCCCCGCCAC CCACCACGTC CCCACCGGAG CCTCCCTACA GCACACCTCC AGTCCCCTCC 
TCCTCAGGGC GCCTCACCCC CTCCCCTCGG GGAGGGCCCT TCAACCCTGG CTCTGGTGGC 
CCCCTCCCCG CCTCCTCCCC TGCATCCTTT GACGGGCCCT CCCCTCCCGA CACTCGCGTG 
GGGAGCCGCG AGAAGAGCCT GTACCACAGT GGGCCCCTGC CCCCGGCCCA CCACCACCCG 
CCCCACCACC ACCACCACCA CGCCCCGCCC CCTCAGCCCC ACCACCACCA CGCCCACCCC 
CCTCATCCTC CCGAGATGGA GACAGGCGGC TCTCCCGACG ACCCTCCACC CCGCCTGGCT 
CTGGGGCCCC AGCCCAGCCT GCGAGGCTGG AGGGGCGGCG GGCCCAGCCC GACCCCGGGG 
GCCCCGTCCC CATCGCACCA CGGCAGCGCG GGCGGGGGCG GCGGCTCCTC CCAGGGCCCG 
GCTCTACGCT ATTTCCAGCT GCCCCCGCGG GCGGCCAGCG CAGCCATGTA CGTGCCCGCC 
CGCTCGGGCC GCGGCCGCAA GGGCCCGCTG GTCAAGCAGA CCAAGGTGGA AGGCGAGCCC 
CAGAAGGGCG GCGGCCTCCC GCCCGCGCCG TCGCCCACGT CCCCGGCCTC CCCGCAGCCG 
CCGCCCGCCG TGGCCGCGCC CTCGGAGAAG AACTCCATCC CCATCCCCAC CATCATCATC 
AAGGCCCCGT CCACCAGTAG CAGCGGCCGC AGCAGCCAGG GCAGCAGCAC CGAGGCGGAG 
CCCCCCACCC AGCCGGAGCC CACGGGAGGC GGCGGCGGCG GCGGCTCCTC GCCCAGCCCC 
GCCCCGGCCA TGTCACCCGT GCCCCCGTCC CCCTCGCCCG TGCCCACCCC CGCCTCGCCC 
AGCGGCCCGG CCACGCTGGA CTTCACGAGC CAGTTCGGGG CCGCCCTGGT GGGGGCGGCC 
CGGAGGGAGG GGGGCTGGCA GAATGAGGCG CGCCGGCGCT CCACGCTGTT CCTGTCCACC 
GACGCGGGGG ACGAGGACGG CGGGGACGGC GGGCTGGGCA CAGGGGCGGC CCCGGGCCCG 
CGGCTGCGCC ACTCCAAATC CATCGACGAG GGCATGTTCT CCGCCGAGCC CTACCTCCGA 
CTGGAGTCTG CGGGCAGCGG CGCGGGCTAC GGCGGCTACG GGGCCGGTAG CCGAGCCTAC 
GGGGGTGGCG GGGGCAGCAG CGCCTTCACC AGCTTCCTGC CCCCGCGACC CCTGGTGCAC 
CCGCTGACCG GCAAGGCCCT GGATCCCGCC TCCCCGCTGG GGCTGGCCCT GGCCGCCCGC 
GAGCGAGCGC TGAAGGAGTC CTCGGAGGGC GGCGGGGCCC CCCAGCCGCC TCCCAGGCCC 
CCATCGCCCC GCTACGAGGC CCCGCCGCCC ACCCCGCACC ACCACTCGCC CCACGCCCAC 
CACGAGCCAG TGCTGCGTCT CTGGGGGGCC TCCCCGCCGG ACCCTGCGCG CCGGGAGCTG 
GGGTACAGGG CCGGGCTGGG CAGCCAGGAG AAGTCCCTTC CCGCCAGCCC GCCCGCCGCC 
CGGCGTTCCC TGCTACACCG CCTGCCGCCC ACCGCTCCCG GGGTGGGGCC CCTCCTGCTG 
CAGCTGGGGA CGGAGCCCCC GGCCCCGCAC CCCGGAGTAA GCAAGCCCTG GAGGTCCGCA 
GCCCCCGAAG AACCCGAGCG GCTGCCGCTG CACGTGCGGT TCCTTGAAAA CTGCCAGCCC 
CGGGCCCCTG TGACGAGCGG AAGGGGTCCC CCCTCGGAGG ACGGGCCGGG GGTCCCGCCG 
CCCAGCCCAC GCCGGTCCGT GCCCCCCTCC CCGACCTCCC CGAGGGCCAG CGAAGAGAAC 
GGGCTGCCCC TGCTGGTCCT GCCGCCTCCC GCCCCCTCGG TGGATGTGGA AGATGGCGAA 
TTCCTTTTCG TGGAACCGCT GCCTCCGCCT CTGGAATTCT CCAACAGCTT CGAAAAGCCA 
GAGTCGCCCC TCACGCCTGG GCCTCCCCAC CCGCTGCCCG ACACACCTGC CCCTGCCACC 
CCGTTACCCC CTGTGCCACC CCCGGCTGTG GCCGCAGCCC CTCCCACCCT GGACTCCACC 
GCATCCAGCC TGACATCCTA TGACAGCGAG GTGGCCACCC TGACCCAGGG GGCCTCCGCC 
GCTCCTGGGG ACCCCCATCC ACCAGGCCCG CCTGCCCCAG CAGCACCGGC TCCCGCTGCC 
CCACAGCCTG GCCCGGACCC TCCGCCTGGC ACGGATTCTG GCATCGAGGA GGTGGACAGT 
CGGAGCAGCA GTGACCACCC ACTGGAGACC ATCAGCAGCG CCTCCACGCT GAGCAGCCTA 
TCTGCCGAAG GTGGTGGCAG CGCAGGGGGT GGGGGCGGGG CTGGGGCCGG TGTGGCCAGT 
GGGCCGGAGC TTCTGGACAC CTATGTGGCC TACCTGGACG GCCAGGCCTT TGGGGGCAGC 
AGTACTCCCG GCCCGCCATA CCCTCCTCAG CTCATGACTC CCTCTAAGCT CCGGGGCCGG 
GCGCTAGGAG CCAGCGGAGG CCTGCGGCCT GGCCCCAGCG GGGGACTCCG AGACCCTGTT 
ACCCCCACCA GCCCCACCGT CTCGGTGACA GGGGCTGGAA CCGATGGGCT GCTGGCCCTG 
CGTGCTTGTT CAGGACCCCC CACGGCAGGC GTGGCGGGGG GTCCGGTGGC TGTAGAGCCA 
GAAGTCCCAC CGGTGCCCTT GCCGACGGCC TCCTCTCTGC CCCGGAAGCT GCTGCCCTGG 
GAGGAGGGCC CGGGCCCACC GCCACCACCT CTGCCCGGGC CCTTGGCCCA GCCTCAGGCC 
TCAGCCTTGG CCACAGTAAA AGCCAGCATC ATCAGTGAAC TCAGCTCCAA GCTTCAGCAG 
TTTGGGGGCT CCTCGGCAGC TGGCGGCGCT CTGCCCTGGG CCCGAGGAGG CAGTGGGGGA 
GGCGGAGACA GCCACCACGG GGGAGCCAGC TATGTCCCCG AGAGGACCTC CTCCCTGCAG 
CGGCAGAGAC TCTCCGACGA CTCCCAGTCC TCACTCCTCT CCAAGCCTGT CAGCAGCCTG 
TTTCAGAACT GGCCCAAACC ACCTCTGCCG CCACTCCCCA CCGGAACAGG GGTCTCCCCT 
ACAGCCGCTG CGGCCCCAGG GGCCACCTCA CCCTCAGCCT CCTCCTCCTC CACGTCCACC 
CGCCACCTCC AGGGCGTGGA GTTCGAGATG CGGCCCCCTC TGCTCCGCCG GGCCCCCAGC 
CCCTCGCTGC TGCCCGCCTC GGAGCACAAG GTCAGCCCTG CGCCCAGGCC CTCGTCCCTG 
CCCATCCTGC CTTCCGGACC CCTCTACCCA GGCCTCTTTG ACATCCGTGG CTCCCCAACT 
GGAGGGGCAG GAGGCTCGGC TGACCCCTTC GCCCCAGTCT TTGTGCCGCC ACACCCGGGG 
ATATCCGGGG GGCTCGGGGG AGCCTTGTCA GGGGCCTCGC GCTCCCTCTC ACCGACCCGC 
CTGCTCTCGC TGCCCCCGGA CAAGCCGTTT GGCGCTAAAC CTCTGGGGTT CTGGACCAAG 
TTCGACGTGG CTGATTGGCT GGAGTGGCTG GGTTTGGCGG AGCACCGAGC CCAGTTCCTG 
GACCACGAGA TCGATGGCTC CCACCTGCCC GCCTTGACCA AGGAGGACTA CGTCGATCTA 
GGTGTGACCA GGGTGGGCCA CCGCATGAAC ATCGACCGGG CTCTCAAATT CTTCCTGGAG 
AGGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_057232.2
CDS	441..6926
Translation	MTHSPATSEDEERHSASECPEGGSESDSSPDGPGRGPRGTRGQGSGAPGSLASVRGLQGRSMSVPDDAHFSMMVFRIGIPDLHQTKCLRFNPDATIWTAKQQVLCALSESLQDVLNYGLFQPATSGRDANFLEEERLLREYPQSFEKGVPYLEFRYKTRVYKQTNLDEKQLAKLHTKTGLKKFLEYVQLGTSDKVARLLDKGLDPNYHDSDSGETPLTLAAQTEGSVEVIRTLCLGGAHIDFRARDGMTALHKAACARHCLALTALLDLGGSPNYKDRRGLTPLFHTAMVGGDPRCCELLLFNRAQLGIADENGWQEIHQACQRGHSQHLEHLLFYGAEPGAQNASGNTALHICALYNKETCARILLYRGADKDVKNNNGQTPFQVAVIAGNFELGELIRNHREQDVVPFQESPKYAARRRGPPGTGLTVPPALLRANSDTSMALPDWMVFSAPGAASSGAPGPTSGSQGQSQPSAPTTKLSSGTLRSASSPRGARARSPSRGRHPEDAKRQPRGRPSSSGTPREGPAGGTGGSGGPGGSLGSRGRRRKLYSAVPGRSFMAVKSYQAQAEGEISLSKGEKIKVLSIGEGGFWEGQVKGRVGWFPSDCLEEVANRSQESKQESRSDKAKRLFRHYTVGSYDSFDAPSLMDGIGPGSDYIIKEKTVLLQKKDSEGFGFVLRGAKAQTPIEEFTPTPAFPALQYLESVDEGGVAWRAGLRMGDFLIEVNGQNVVKVGHRQVVNMIRQGGNTLMVKVVMVTRHPDMDEAVHKKAPQQAKRLPPPTISLRSKSMTSELEEMEYEQQPAPVPSMEKKRTVYQMALNKLDEILAAAQQTISASESPGPGGLASLGKHRPKGFFATESSFDPHHRAQPSYERPSFLPPGPGLMLRQKSIGAAEDDRPYLAPPAMKFSRSLSVPGSEDIPPPPTTSPPEPPYSTPPVPSSSGRLTPSPRGGPFNPGSGGPLPASSPASFDGPSPPDTRVGSREKSLYHSGPLPPAHHHPPHHHHHHAPPPQPHHHHAHPPHPPEMETGGSPDDPPPRLALGPQPSLRGWRGGGPSPTPGAPSPSHHGSAGGGGGSSQGPALRYFQLPPRAASAAMYVPARSGRGRKGPLVKQTKVEGEPQKGGGLPPAPSPTSPASPQPPPAVAAPSEKNSIPIPTIIIKAPSTSSSGRSSQGSSTEAEPPTQPEPTGGGGGGGSSPSPAPAMSPVPPSPSPVPTPASPSGPATLDFTSQFGAALVGAARREGGWQNEARRRSTLFLSTDAGDEDGGDGGLGTGAAPGPRLRHSKSIDEGMFSAEPYLRLESAGSGAGYGGYGAGSRAYGGGGGSSAFTSFLPPRPLVHPLTGKALDPASPLGLALAARERALKESSEGGGAPQPPPRPPSPRYEAPPPTPHHHSPHAHHEPVLRLWGASPPDPARRELGYRAGLGSQEKSLPASPPAARRSLLHRLPPTAPGVGPLLLQLGTEPPAPHPGVSKPWRSAAPEEPERLPLHVRFLENCQPRAPVTSGRGPPSEDGPGVPPPSPRRSVPPSPTSPRASEENGLPLLVLPPPAPSVDVEDGEFLFVEPLPPPLEFSNSFEKPESPLTPGPPHPLPDTPAPATPLPPVPPPAVAAAPPTLDSTASSLTSYDSEVATLTQGASAAPGDPHPPGPPAPAAPAPAAPQPGPDPPPGTDSGIEEVDSRSSSDHPLETISSASTLSSLSAEGGGSAGGGGGAGAGVASGPELLDTYVAYLDGQAFGGSSTPGPPYPPQLMTPSKLRGRALGASGGLRPGPSGGLRDPVTPTSPTVSVTGAGTDGLLALRACSGPPTAGVAGGPVAVEPEVPPVPLPTASSLPRKLLPWEEGPGPPPPPLPGPLAQPQASALATVKASIISELSSKLQQFGGSSAAGGALPWARGGSGGGGDSHHGGASYVPERTSSLQRQRLSDDSQSSLLSKPVSSLFQNWPKPPLPPLPTGTGVSPTAAAAPGATSPSASSSSTSTRHLQGVEFEMRPPLLRRAPSPSLLPASEHKVSPAPRPSSLPILPSGPLYPGLFDIRGSPTGGAGGSADPFAPVFVPPHPGISGGLGGALSGASRSLSPTRLLSLPPDKPFGAKPLGFWTKFDVADWLEWLGLAEHRAQFLDHEIDGSHLPALTKEDYVDLGVTRVGHRMNIDRALKFFLER

Target ORF information:

RefSeq Version	NM_016148.5
Organism	Homo sapiens(human)
Definition	Homo sapiens SH3 and multiple ankyrin repeat domains 1 (SHANK1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_016148.5

ORF Insert Sequence:

ATGACCCACA GCCCCGCGAC AAGCGAGGAC GAGGAACGCC ACAGTGCCAG CGAGTGTCCC 
GAGGGGGGCT CAGAGTCCGA CAGCTCCCCA GACGGGCCAG GTCGAGGCCC CCGGGGGACC 
CGGGGCCAGG GCAGTGGGGC ACCTGGTAGC CTGGCCTCTG TTAGAGGCCT CCAGGGCCGC 
TCAATGTCCG TCCCAGACGA CGCCCACTTC AGCATGATGG TCTTCAGGAT TGGCATCCCG 
GACCTGCACC AGACAAAATG CCTTCGCTTC AACCCCGATG CCACCATCTG GACGGCCAAG 
CAGCAGGTGC TCTGTGCCCT GAGCGAGAGC CTGCAGGATG TGCTCAACTA TGGCCTGTTC 
CAACCGGCCA CCTCCGGCCG CGATGCCAAC TTCCTGGAGG AGGAGAGGCT GCTGCGGGAG 
TACCCCCAGT CCTTTGAGAA GGGGGTCCCC TACCTGGAGT TCCGATACAA GACCCGAGTT 
TACAAACAGA CCAACCTGGA TGAGAAGCAG CTGGCCAAGT TGCACACGAA GACGGGGTTG 
AAGAAGTTCC TGGAGTATGT GCAGCTCGGG ACATCTGACA AGGTGGCGCG GCTGCTGGAC 
AAGGGGCTGG ACCCCAATTA CCATGACTCG GATTCGGGAG AGACCCCCTT GACACTGGCG 
GCCCAGACCG AAGGCTCTGT AGAGGTGATT CGAACCCTGT GCCTGGGCGG GGCCCACATT 
GACTTCCGGG CCCGGGATGG CATGACCGCA CTGCATAAGG CCGCATGCGC CCGACACTGC 
CTGGCACTCA CGGCGCTCCT GGACCTTGGG GGTTCCCCCA ACTACAAGGA CCGTCGGGGG 
CTGACCCCTC TGTTCCACAC GGCCATGGTG GGTGGTGACC CCCGATGCTG CGAGCTGCTC 
CTGTTCAACA GGGCCCAGCT GGGCATAGCT GATGAGAACG GCTGGCAGGA AATCCACCAG 
GCCTGCCAGC GGGGTCACTC TCAGCACCTG GAGCATCTGC TTTTCTACGG GGCTGAGCCT 
GGAGCCCAGA ACGCCTCGGG GAACACGGCT CTGCACATCT GCGCCCTCTA CAACAAGGAG 
ACCTGTGCCA GGATCCTCCT GTATCGAGGT GCCGACAAGG ATGTGAAGAA CAACAACGGA 
CAGACCCCCT TCCAGGTGGC AGTGATTGCT GGGAATTTTG AGCTGGGGGA GCTGATCCGA 
AACCACCGAG AACAGGATGT GGTGCCCTTC CAGGAGTCCC CCAAGTACGC GGCCCGGCGA 
CGGGGGCCCC CAGGCACAGG GCTGACGGTG CCCCCGGCGC TGCTGCGGGC CAACAGTGAC 
ACCAGCATGG CGCTGCCCGA CTGGATGGTG TTCTCCGCCC CGGGGGCCGC GTCCTCTGGG 
GCCCCTGGCC CTACCTCAGG GTCCCAGGGC CAGTCGCAGC CCTCGGCCCC CACCACCAAG 
CTCAGCAGCG GGACCCTCCG AAGTGCCAGC AGCCCCCGGG GTGCCAGGGC CCGCTCTCCA 
TCCCGAGGGA GGCACCCTGA GGACGCCAAG AGGCAGCCCC GAGGCCGGCC CAGCTCCAGC 
GGGACACCCC GGGAAGGGCC AGCCGGGGGC ACGGGGGGCT CAGGGGGCCC CGGGGGCTCC 
CTGGGCAGCC GCGGGAGGCG GAGGAAGCTC TACTCAGCGG TACCCGGACG CTCCTTCATG 
GCTGTGAAGT CCTACCAGGC CCAAGCCGAG GGGGAGATCT CCCTGAGCAA GGGCGAGAAG 
ATCAAAGTAC TTAGCATCGG GGAAGGAGGC TTCTGGGAAG GCCAGGTCAA AGGTCGTGTT 
GGCTGGTTCC CCTCTGACTG CCTGGAAGAA GTGGCGAATC GCTCTCAGGA GAGCAAGCAA 
GAAAGCCGCA GTGACAAGGC AAAGAGACTC TTCCGGCATT ATACCGTGGG CTCCTACGAC 
AGCTTTGATG CCCCAAGCTT AATGGATGGG ATTGGCCCAG GGAGCGATTA CATCATTAAG 
GAGAAGACAG TCTTGCTGCA GAAGAAGGAC AGTGAGGGGT TTGGGTTCGT GCTCCGGGGG 
GCCAAGGCGC AGACCCCCAT CGAGGAGTTC ACCCCCACCC CGGCCTTCCC GGCGCTGCAG 
TACCTGGAGT CGGTGGACGA GGGTGGCGTG GCATGGCGAG CTGGACTGCG AATGGGAGAC 
TTCCTCATCG AGGTGAACGG GCAGAATGTG GTGAAGGTCG GCCACCGACA GGTGGTGAAC 
ATGATCCGCC AAGGGGGCAA CACGCTGATG GTGAAGGTGG TGATGGTCAC CAGGCACCCG 
GACATGGATG AGGCAGTGCA CAAGAAAGCA CCCCAGCAGG CCAAGCGGCT GCCGCCCCCA 
ACCATCTCCC TGCGTTCCAA ATCTATGACC TCAGAGCTGG AGGAGATGGA GTACGAGCAG 
CAGCCGGCGC CGGTGCCCAG CATGGAGAAA AAGCGGACCG TGTATCAGAT GGCTCTCAAC 
AAACTGGACG AAATCCTGGC CGCAGCTCAA CAGACCATCA GTGCAAGCGA AAGCCCTGGT 
CCCGGTGGCC TCGCGTCCCT GGGCAAACAC CGACCCAAAG GTTTCTTTGC CACTGAGTCG 
AGCTTCGATC CCCACCACCG TGCCCAGCCA AGTTACGAGC GTCCTTCTTT CCTGCCTCCA 
GGACCTGGGT TGATGCTCCG GCAAAAATCT ATCGGTGCGG CAGAAGATGA CAGACCTTAC 
CTAGCACCCC CAGCCATGAA ATTCAGCCGC AGCCTGTCTG TGCCTGGTTC GGAGGACATT 
CCCCCGCCAC CCACCACGTC CCCACCGGAG CCTCCCTACA GCACACCTCC AGTCCCCTCC 
TCCTCAGGGC GCCTCACCCC CTCCCCTCGG GGAGGGCCCT TCAACCCTGG CTCTGGTGGC 
CCCCTCCCCG CCTCCTCCCC TGCATCCTTT GACGGGCCCT CCCCTCCCGA CACTCGCGTG 
GGGAGCCGCG AGAAGAGCCT GTACCACAGT GGGCCCCTGC CCCCGGCCCA CCACCACCCG 
CCCCACCACC ACCACCACCA CGCCCCGCCC CCTCAGCCCC ACCACCACCA CGCCCACCCC 
CCTCATCCTC CCGAGATGGA GACAGGCGGC TCTCCCGACG ACCCTCCACC CCGCCTGGCT 
CTGGGGCCCC AGCCCAGCCT GCGAGGCTGG AGGGGCGGCG GGCCCAGCCC GACCCCGGGG 
GCCCCGTCCC CATCGCACCA CGGCAGCGCG GGCGGGGGCG GCGGCTCCTC CCAGGGCCCG 
GCTCTACGCT ATTTCCAGCT GCCCCCGCGG GCGGCCAGCG CAGCCATGTA CGTGCCCGCC 
CGCTCGGGCC GCGGCCGCAA GGGCCCGCTG GTCAAGCAGA CCAAGGTGGA AGGCGAGCCC 
CAGAAGGGCG GCGGCCTCCC GCCCGCGCCG TCGCCCACGT CCCCGGCCTC CCCGCAGCCG 
CCGCCCGCCG TGGCCGCGCC CTCGGAGAAG AACTCCATCC CCATCCCCAC CATCATCATC 
AAGGCCCCGT CCACCAGTAG CAGCGGCCGC AGCAGCCAGG GCAGCAGCAC CGAGGCGGAG 
CCCCCCACCC AGCCGGAGCC CACGGGAGGC GGCGGCGGCG GCGGCTCCTC GCCCAGCCCC 
GCCCCGGCCA TGTCACCCGT GCCCCCGTCC CCCTCGCCCG TGCCCACCCC CGCCTCGCCC 
AGCGGCCCGG CCACGCTGGA CTTCACGAGC CAGTTCGGGG CCGCCCTGGT GGGGGCGGCC 
CGGAGGGAGG GGGGCTGGCA GAATGAGGCG CGCCGGCGCT CCACGCTGTT CCTGTCCACC 
GACGCGGGGG ACGAGGACGG CGGGGACGGC GGGCTGGGCA CAGGGGCGGC CCCGGGCCCG 
CGGCTGCGCC ACTCCAAATC CATCGACGAG GGCATGTTCT CCGCCGAGCC CTACCTCCGA 
CTGGAGTCTG CGGGCAGCGG CGCGGGCTAC GGCGGCTACG GGGCCGGTAG CCGAGCCTAC 
GGGGGTGGCG GGGGCAGCAG CGCCTTCACC AGCTTCCTGC CCCCGCGACC CCTGGTGCAC 
CCGCTGACCG GCAAGGCCCT GGATCCCGCC TCCCCGCTGG GGCTGGCCCT GGCCGCCCGC 
GAGCGAGCGC TGAAGGAGTC CTCGGAGGGC GGCGGGGCCC CCCAGCCGCC TCCCAGGCCC 
CCATCGCCCC GCTACGAGGC CCCGCCGCCC ACCCCGCACC ACCACTCGCC CCACGCCCAC 
CACGAGCCAG TGCTGCGTCT CTGGGGGGCC TCCCCGCCGG ACCCTGCGCG CCGGGAGCTG 
GGGTACAGGG CCGGGCTGGG CAGCCAGGAG AAGTCCCTTC CCGCCAGCCC GCCCGCCGCC 
CGGCGTTCCC TGCTACACCG CCTGCCGCCC ACCGCTCCCG GGGTGGGGCC CCTCCTGCTG 
CAGCTGGGGA CGGAGCCCCC GGCCCCGCAC CCCGGAGTAA GCAAGCCCTG GAGGTCCGCA 
GCCCCCGAAG AACCCGAGCG GCTGCCGCTG CACGTGCGGT TCCTTGAAAA CTGCCAGCCC 
CGGGCCCCTG TGACGAGCGG AAGGGGTCCC CCCTCGGAGG ACGGGCCGGG GGTCCCGCCG 
CCCAGCCCAC GCCGGTCCGT GCCCCCCTCC CCGACCTCCC CGAGGGCCAG CGAAGAGAAC 
GGGCTGCCCC TGCTGGTCCT GCCGCCTCCC GCCCCCTCGG TGGATGTGGA AGATGGCGAA 
TTCCTTTTCG TGGAACCGCT GCCTCCGCCT CTGGAATTCT CCAACAGCTT CGAAAAGCCA 
GAGTCGCCCC TCACGCCTGG GCCTCCCCAC CCGCTGCCCG ACACACCTGC CCCTGCCACC 
CCGTTACCCC CTGTGCCACC CCCGGCTGTG GCCGCAGCCC CTCCCACCCT GGACTCCACC 
GCATCCAGCC TGACATCCTA TGACAGCGAG GTGGCCACCC TGACCCAGGG GGCCTCCGCC 
GCTCCTGGGG ACCCCCATCC ACCAGGCCCG CCTGCCCCAG CAGCACCGGC TCCCGCTGCC 
CCACAGCCTG GCCCGGACCC TCCGCCTGGC ACGGATTCTG GCATCGAGGA GGTGGACAGT 
CGGAGCAGCA GTGACCACCC ACTGGAGACC ATCAGCAGCG CCTCCACGCT GAGCAGCCTA 
TCTGCCGAAG GTGGTGGCAG CGCAGGGGGT GGGGGCGGGG CTGGGGCCGG TGTGGCCAGT 
GGGCCGGAGC TTCTGGACAC CTATGTGGCC TACCTGGACG GCCAGGCCTT TGGGGGCAGC 
AGTACTCCCG GCCCGCCATA CCCTCCTCAG CTCATGACTC CCTCTAAGCT CCGGGGCCGG 
GCGCTAGGAG CCAGCGGAGG CCTGCGGCCT GGCCCCAGCG GGGGACTCCG AGACCCTGTT 
ACCCCCACCA GCCCCACCGT CTCGGTGACA GGGGCTGGAA CCGATGGGCT GCTGGCCCTG 
CGTGCTTGTT CAGGACCCCC CACGGCAGGC GTGGCGGGGG GTCCGGTGGC TGTAGAGCCA 
GAAGTCCCAC CGGTGCCCTT GCCGACGGCC TCCTCTCTGC CCCGGAAGCT GCTGCCCTGG 
GAGGAGGGCC CGGGCCCACC GCCACCACCT CTGCCCGGGC CCTTGGCCCA GCCTCAGGCC 
TCAGCCTTGG CCACAGTAAA AGCCAGCATC ATCAGTGAAC TCAGCTCCAA GCTTCAGCAG 
TTTGGGGGCT CCTCGGCAGC TGGCGGCGCT CTGCCCTGGG CCCGAGGAGG CAGTGGGGGA 
GGCGGAGACA GCCACCACGG GGGAGCCAGC TATGTCCCCG AGAGGACCTC CTCCCTGCAG 
CGGCAGAGAC TCTCCGACGA CTCCCAGTCC TCACTCCTCT CCAAGCCTGT CAGCAGCCTG 
TTTCAGAACT GGCCCAAACC ACCTCTGCCG CCACTCCCCA CCGGAACAGG GGTCTCCCCT 
ACAGCCGCTG CGGCCCCAGG GGCCACCTCA CCCTCAGCCT CCTCCTCCTC CACGTCCACC 
CGCCACCTCC AGGGCGTGGA GTTCGAGATG CGGCCCCCTC TGCTCCGCCG GGCCCCCAGC 
CCCTCGCTGC TGCCCGCCTC GGAGCACAAG GTCAGCCCTG CGCCCAGGCC CTCGTCCCTG 
CCCATCCTGC CTTCCGGACC CCTCTACCCA GGCCTCTTTG ACATCCGTGG CTCCCCAACT 
GGAGGGGCAG GAGGCTCGGC TGACCCCTTC GCCCCAGTCT TTGTGCCGCC ACACCCGGGG 
ATATCCGGGG GGCTCGGGGG AGCCTTGTCA GGGGCCTCGC GCTCCCTCTC ACCGACCCGC 
CTGCTCTCGC TGCCCCCGGA CAAGCCGTTT GGCGCTAAAC CTCTGGGGTT CTGGACCAAG 
TTCGACGTGG CTGATTGGCT GGAGTGGCTG GGTTTGGCGG AGCACCGAGC CCAGTTCCTG 
GACCACGAGA TCGATGGCTC CCACCTGCCC GCCTTGACCA AGGAGGACTA CGTCGATCTA 
GGTGTGACCA GGGTGGGCCA CCGCATGAAC ATCGACCGGG CTCTCAAATT CTTCCTGGAG 
AGGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SHANK1 ( XM_006723233.3 ) cDNA ORF clone, Homo sapiens(human) -> XP_006723296.1 Homo sapiens SH3 and multiple ankyrin repeat domains 1 (SHANK1), transcript variant X2, mRNA.

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CloneID	OHu07151
Clone ID Related Accession (Same CDS sequence)	NM_016148.3 , XM_006723233.3 , NM_016148.4 , NM_016148.5
Accession Version	XM_006723233.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 6486bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(Human)
Product	SH3 and multiple ankyrin repeat domains protein 1 isoform X2
Comment	MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000019.10) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_006723233.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGACCCACA GCCCCGCGAC AAGCGAGGAC GAGGAACGCC ACAGTGCCAG CGAGTGTCCC 
GAGGGGGGCT CAGAGTCCGA CAGCTCCCCA GACGGGCCAG GTCGAGGCCC CCGGGGGACC 
CGGGGCCAGG GCAGTGGGGC ACCTGGTAGC CTGGCCTCTG TTAGAGGCCT CCAGGGCCGC 
TCAATGTCCG TCCCAGACGA CGCCCACTTC AGCATGATGG TCTTCAGGAT TGGCATCCCG 
GACCTGCACC AGACAAAATG CCTTCGCTTC AACCCCGATG CCACCATCTG GACGGCCAAG 
CAGCAGGTGC TCTGTGCCCT GAGCGAGAGC CTGCAGGATG TGCTCAACTA TGGCCTGTTC 
CAACCGGCCA CCTCCGGCCG CGATGCCAAC TTCCTGGAGG AGGAGAGGCT GCTGCGGGAG 
TACCCCCAGT CCTTTGAGAA GGGGGTCCCC TACCTGGAGT TCCGATACAA GACCCGAGTT 
TACAAACAGA CCAACCTGGA TGAGAAGCAG CTGGCCAAGT TGCACACGAA GACGGGGTTG 
AAGAAGTTCC TGGAGTATGT GCAGCTCGGG ACATCTGACA AGGTGGCGCG GCTGCTGGAC 
AAGGGGCTGG ACCCCAATTA CCATGACTCG GATTCGGGAG AGACCCCCTT GACACTGGCG 
GCCCAGACCG AAGGCTCTGT AGAGGTGATT CGAACCCTGT GCCTGGGCGG GGCCCACATT 
GACTTCCGGG CCCGGGATGG CATGACCGCA CTGCATAAGG CCGCATGCGC CCGACACTGC 
CTGGCACTCA CGGCGCTCCT GGACCTTGGG GGTTCCCCCA ACTACAAGGA CCGTCGGGGG 
CTGACCCCTC TGTTCCACAC GGCCATGGTG GGTGGTGACC CCCGATGCTG CGAGCTGCTC 
CTGTTCAACA GGGCCCAGCT GGGCATAGCT GATGAGAACG GCTGGCAGGA AATCCACCAG 
GCCTGCCAGC GGGGTCACTC TCAGCACCTG GAGCATCTGC TTTTCTACGG GGCTGAGCCT 
GGAGCCCAGA ACGCCTCGGG GAACACGGCT CTGCACATCT GCGCCCTCTA CAACAAGGAG 
ACCTGTGCCA GGATCCTCCT GTATCGAGGT GCCGACAAGG ATGTGAAGAA CAACAACGGA 
CAGACCCCCT TCCAGGTGGC AGTGATTGCT GGGAATTTTG AGCTGGGGGA GCTGATCCGA 
AACCACCGAG AACAGGATGT GGTGCCCTTC CAGGAGTCCC CCAAGTACGC GGCCCGGCGA 
CGGGGGCCCC CAGGCACAGG GCTGACGGTG CCCCCGGCGC TGCTGCGGGC CAACAGTGAC 
ACCAGCATGG CGCTGCCCGA CTGGATGGTG TTCTCCGCCC CGGGGGCCGC GTCCTCTGGG 
GCCCCTGGCC CTACCTCAGG GTCCCAGGGC CAGTCGCAGC CCTCGGCCCC CACCACCAAG 
CTCAGCAGCG GGACCCTCCG AAGTGCCAGC AGCCCCCGGG GTGCCAGGGC CCGCTCTCCA 
TCCCGAGGGA GGCACCCTGA GGACGCCAAG AGGCAGCCCC GAGGCCGGCC CAGCTCCAGC 
GGGACACCCC GGGAAGGGCC AGCCGGGGGC ACGGGGGGCT CAGGGGGCCC CGGGGGCTCC 
CTGGGCAGCC GCGGGAGGCG GAGGAAGCTC TACTCAGCGG TACCCGGACG CTCCTTCATG 
GCTGTGAAGT CCTACCAGGC CCAAGCCGAG GGGGAGATCT CCCTGAGCAA GGGCGAGAAG 
ATCAAAGTAC TTAGCATCGG GGAAGGAGGC TTCTGGGAAG GCCAGGTCAA AGGTCGTGTT 
GGCTGGTTCC CCTCTGACTG CCTGGAAGAA GTGGCGAATC GCTCTCAGGA GAGCAAGCAA 
GAAAGCCGCA GTGACAAGGC AAAGAGACTC TTCCGGCATT ATACCGTGGG CTCCTACGAC 
AGCTTTGATG CCCCAAGCTT AATGGATGGG ATTGGCCCAG GGAGCGATTA CATCATTAAG 
GAGAAGACAG TCTTGCTGCA GAAGAAGGAC AGTGAGGGGT TTGGGTTCGT GCTCCGGGGG 
GCCAAGGCGC AGACCCCCAT CGAGGAGTTC ACCCCCACCC CGGCCTTCCC GGCGCTGCAG 
TACCTGGAGT CGGTGGACGA GGGTGGCGTG GCATGGCGAG CTGGACTGCG AATGGGAGAC 
TTCCTCATCG AGGTGAACGG GCAGAATGTG GTGAAGGTCG GCCACCGACA GGTGGTGAAC 
ATGATCCGCC AAGGGGGCAA CACGCTGATG GTGAAGGTGG TGATGGTCAC CAGGCACCCG 
GACATGGATG AGGCAGTGCA CAAGAAAGCA CCCCAGCAGG CCAAGCGGCT GCCGCCCCCA 
ACCATCTCCC TGCGTTCCAA ATCTATGACC TCAGAGCTGG AGGAGATGGA GTACGAGCAG 
CAGCCGGCGC CGGTGCCCAG CATGGAGAAA AAGCGGACCG TGTATCAGAT GGCTCTCAAC 
AAACTGGACG AAATCCTGGC CGCAGCTCAA CAGACCATCA GTGCAAGCGA AAGCCCTGGT 
CCCGGTGGCC TCGCGTCCCT GGGCAAACAC CGACCCAAAG GTTTCTTTGC CACTGAGTCG 
AGCTTCGATC CCCACCACCG TGCCCAGCCA AGTTACGAGC GTCCTTCTTT CCTGCCTCCA 
GGACCTGGGT TGATGCTCCG GCAAAAATCT ATCGGTGCGG CAGAAGATGA CAGACCTTAC 
CTAGCACCCC CAGCCATGAA ATTCAGCCGC AGCCTGTCTG TGCCTGGTTC GGAGGACATT 
CCCCCGCCAC CCACCACGTC CCCACCGGAG CCTCCCTACA GCACACCTCC AGTCCCCTCC 
TCCTCAGGGC GCCTCACCCC CTCCCCTCGG GGAGGGCCCT TCAACCCTGG CTCTGGTGGC 
CCCCTCCCCG CCTCCTCCCC TGCATCCTTT GACGGGCCCT CCCCTCCCGA CACTCGCGTG 
GGGAGCCGCG AGAAGAGCCT GTACCACAGT GGGCCCCTGC CCCCGGCCCA CCACCACCCG 
CCCCACCACC ACCACCACCA CGCCCCGCCC CCTCAGCCCC ACCACCACCA CGCCCACCCC 
CCTCATCCTC CCGAGATGGA GACAGGCGGC TCTCCCGACG ACCCTCCACC CCGCCTGGCT 
CTGGGGCCCC AGCCCAGCCT GCGAGGCTGG AGGGGCGGCG GGCCCAGCCC GACCCCGGGG 
GCCCCGTCCC CATCGCACCA CGGCAGCGCG GGCGGGGGCG GCGGCTCCTC CCAGGGCCCG 
GCTCTACGCT ATTTCCAGCT GCCCCCGCGG GCGGCCAGCG CAGCCATGTA CGTGCCCGCC 
CGCTCGGGCC GCGGCCGCAA GGGCCCGCTG GTCAAGCAGA CCAAGGTGGA AGGCGAGCCC 
CAGAAGGGCG GCGGCCTCCC GCCCGCGCCG TCGCCCACGT CCCCGGCCTC CCCGCAGCCG 
CCGCCCGCCG TGGCCGCGCC CTCGGAGAAG AACTCCATCC CCATCCCCAC CATCATCATC 
AAGGCCCCGT CCACCAGTAG CAGCGGCCGC AGCAGCCAGG GCAGCAGCAC CGAGGCGGAG 
CCCCCCACCC AGCCGGAGCC CACGGGAGGC GGCGGCGGCG GCGGCTCCTC GCCCAGCCCC 
GCCCCGGCCA TGTCACCCGT GCCCCCGTCC CCCTCGCCCG TGCCCACCCC CGCCTCGCCC 
AGCGGCCCGG CCACGCTGGA CTTCACGAGC CAGTTCGGGG CCGCCCTGGT GGGGGCGGCC 
CGGAGGGAGG GGGGCTGGCA GAATGAGGCG CGCCGGCGCT CCACGCTGTT CCTGTCCACC 
GACGCGGGGG ACGAGGACGG CGGGGACGGC GGGCTGGGCA CAGGGGCGGC CCCGGGCCCG 
CGGCTGCGCC ACTCCAAATC CATCGACGAG GGCATGTTCT CCGCCGAGCC CTACCTCCGA 
CTGGAGTCTG CGGGCAGCGG CGCGGGCTAC GGCGGCTACG GGGCCGGTAG CCGAGCCTAC 
GGGGGTGGCG GGGGCAGCAG CGCCTTCACC AGCTTCCTGC CCCCGCGACC CCTGGTGCAC 
CCGCTGACCG GCAAGGCCCT GGATCCCGCC TCCCCGCTGG GGCTGGCCCT GGCCGCCCGC 
GAGCGAGCGC TGAAGGAGTC CTCGGAGGGC GGCGGGGCCC CCCAGCCGCC TCCCAGGCCC 
CCATCGCCCC GCTACGAGGC CCCGCCGCCC ACCCCGCACC ACCACTCGCC CCACGCCCAC 
CACGAGCCAG TGCTGCGTCT CTGGGGGGCC TCCCCGCCGG ACCCTGCGCG CCGGGAGCTG 
GGGTACAGGG CCGGGCTGGG CAGCCAGGAG AAGTCCCTTC CCGCCAGCCC GCCCGCCGCC 
CGGCGTTCCC TGCTACACCG CCTGCCGCCC ACCGCTCCCG GGGTGGGGCC CCTCCTGCTG 
CAGCTGGGGA CGGAGCCCCC GGCCCCGCAC CCCGGAGTAA GCAAGCCCTG GAGGTCCGCA 
GCCCCCGAAG AACCCGAGCG GCTGCCGCTG CACGTGCGGT TCCTTGAAAA CTGCCAGCCC 
CGGGCCCCTG TGACGAGCGG AAGGGGTCCC CCCTCGGAGG ACGGGCCGGG GGTCCCGCCG 
CCCAGCCCAC GCCGGTCCGT GCCCCCCTCC CCGACCTCCC CGAGGGCCAG CGAAGAGAAC 
GGGCTGCCCC TGCTGGTCCT GCCGCCTCCC GCCCCCTCGG TGGATGTGGA AGATGGCGAA 
TTCCTTTTCG TGGAACCGCT GCCTCCGCCT CTGGAATTCT CCAACAGCTT CGAAAAGCCA 
GAGTCGCCCC TCACGCCTGG GCCTCCCCAC CCGCTGCCCG ACACACCTGC CCCTGCCACC 
CCGTTACCCC CTGTGCCACC CCCGGCTGTG GCCGCAGCCC CTCCCACCCT GGACTCCACC 
GCATCCAGCC TGACATCCTA TGACAGCGAG GTGGCCACCC TGACCCAGGG GGCCTCCGCC 
GCTCCTGGGG ACCCCCATCC ACCAGGCCCG CCTGCCCCAG CAGCACCGGC TCCCGCTGCC 
CCACAGCCTG GCCCGGACCC TCCGCCTGGC ACGGATTCTG GCATCGAGGA GGTGGACAGT 
CGGAGCAGCA GTGACCACCC ACTGGAGACC ATCAGCAGCG CCTCCACGCT GAGCAGCCTA 
TCTGCCGAAG GTGGTGGCAG CGCAGGGGGT GGGGGCGGGG CTGGGGCCGG TGTGGCCAGT 
GGGCCGGAGC TTCTGGACAC CTATGTGGCC TACCTGGACG GCCAGGCCTT TGGGGGCAGC 
AGTACTCCCG GCCCGCCATA CCCTCCTCAG CTCATGACTC CCTCTAAGCT CCGGGGCCGG 
GCGCTAGGAG CCAGCGGAGG CCTGCGGCCT GGCCCCAGCG GGGGACTCCG AGACCCTGTT 
ACCCCCACCA GCCCCACCGT CTCGGTGACA GGGGCTGGAA CCGATGGGCT GCTGGCCCTG 
CGTGCTTGTT CAGGACCCCC CACGGCAGGC GTGGCGGGGG GTCCGGTGGC TGTAGAGCCA 
GAAGTCCCAC CGGTGCCCTT GCCGACGGCC TCCTCTCTGC CCCGGAAGCT GCTGCCCTGG 
GAGGAGGGCC CGGGCCCACC GCCACCACCT CTGCCCGGGC CCTTGGCCCA GCCTCAGGCC 
TCAGCCTTGG CCACAGTAAA AGCCAGCATC ATCAGTGAAC TCAGCTCCAA GCTTCAGCAG 
TTTGGGGGCT CCTCGGCAGC TGGCGGCGCT CTGCCCTGGG CCCGAGGAGG CAGTGGGGGA 
GGCGGAGACA GCCACCACGG GGGAGCCAGC TATGTCCCCG AGAGGACCTC CTCCCTGCAG 
CGGCAGAGAC TCTCCGACGA CTCCCAGTCC TCACTCCTCT CCAAGCCTGT CAGCAGCCTG 
TTTCAGAACT GGCCCAAACC ACCTCTGCCG CCACTCCCCA CCGGAACAGG GGTCTCCCCT 
ACAGCCGCTG CGGCCCCAGG GGCCACCTCA CCCTCAGCCT CCTCCTCCTC CACGTCCACC 
CGCCACCTCC AGGGCGTGGA GTTCGAGATG CGGCCCCCTC TGCTCCGCCG GGCCCCCAGC 
CCCTCGCTGC TGCCCGCCTC GGAGCACAAG GTCAGCCCTG CGCCCAGGCC CTCGTCCCTG 
CCCATCCTGC CTTCCGGACC CCTCTACCCA GGCCTCTTTG ACATCCGTGG CTCCCCAACT 
GGAGGGGCAG GAGGCTCGGC TGACCCCTTC GCCCCAGTCT TTGTGCCGCC ACACCCGGGG 
ATATCCGGGG GGCTCGGGGG AGCCTTGTCA GGGGCCTCGC GCTCCCTCTC ACCGACCCGC 
CTGCTCTCGC TGCCCCCGGA CAAGCCGTTT GGCGCTAAAC CTCTGGGGTT CTGGACCAAG 
TTCGACGTGG CTGATTGGCT GGAGTGGCTG GGTTTGGCGG AGCACCGAGC CCAGTTCCTG 
GACCACGAGA TCGATGGCTC CCACCTGCCC GCCTTGACCA AGGAGGACTA CGTCGATCTA 
GGTGTGACCA GGGTGGGCCA CCGCATGAAC ATCGACCGGG CTCTCAAATT CTTCCTGGAG 
AGGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006723296.1
CDS	418..6903
Translation	MTHSPATSEDEERHSASECPEGGSESDSSPDGPGRGPRGTRGQGSGAPGSLASVRGLQGRSMSVPDDAHFSMMVFRIGIPDLHQTKCLRFNPDATIWTAKQQVLCALSESLQDVLNYGLFQPATSGRDANFLEEERLLREYPQSFEKGVPYLEFRYKTRVYKQTNLDEKQLAKLHTKTGLKKFLEYVQLGTSDKVARLLDKGLDPNYHDSDSGETPLTLAAQTEGSVEVIRTLCLGGAHIDFRARDGMTALHKAACARHCLALTALLDLGGSPNYKDRRGLTPLFHTAMVGGDPRCCELLLFNRAQLGIADENGWQEIHQACQRGHSQHLEHLLFYGAEPGAQNASGNTALHICALYNKETCARILLYRGADKDVKNNNGQTPFQVAVIAGNFELGELIRNHREQDVVPFQESPKYAARRRGPPGTGLTVPPALLRANSDTSMALPDWMVFSAPGAASSGAPGPTSGSQGQSQPSAPTTKLSSGTLRSASSPRGARARSPSRGRHPEDAKRQPRGRPSSSGTPREGPAGGTGGSGGPGGSLGSRGRRRKLYSAVPGRSFMAVKSYQAQAEGEISLSKGEKIKVLSIGEGGFWEGQVKGRVGWFPSDCLEEVANRSQESKQESRSDKAKRLFRHYTVGSYDSFDAPSLMDGIGPGSDYIIKEKTVLLQKKDSEGFGFVLRGAKAQTPIEEFTPTPAFPALQYLESVDEGGVAWRAGLRMGDFLIEVNGQNVVKVGHRQVVNMIRQGGNTLMVKVVMVTRHPDMDEAVHKKAPQQAKRLPPPTISLRSKSMTSELEEMEYEQQPAPVPSMEKKRTVYQMALNKLDEILAAAQQTISASESPGPGGLASLGKHRPKGFFATESSFDPHHRAQPSYERPSFLPPGPGLMLRQKSIGAAEDDRPYLAPPAMKFSRSLSVPGSEDIPPPPTTSPPEPPYSTPPVPSSSGRLTPSPRGGPFNPGSGGPLPASSPASFDGPSPPDTRVGSREKSLYHSGPLPPAHHHPPHHHHHHAPPPQPHHHHAHPPHPPEMETGGSPDDPPPRLALGPQPSLRGWRGGGPSPTPGAPSPSHHGSAGGGGGSSQGPALRYFQLPPRAASAAMYVPARSGRGRKGPLVKQTKVEGEPQKGGGLPPAPSPTSPASPQPPPAVAAPSEKNSIPIPTIIIKAPSTSSSGRSSQGSSTEAEPPTQPEPTGGGGGGGSSPSPAPAMSPVPPSPSPVPTPASPSGPATLDFTSQFGAALVGAARREGGWQNEARRRSTLFLSTDAGDEDGGDGGLGTGAAPGPRLRHSKSIDEGMFSAEPYLRLESAGSGAGYGGYGAGSRAYGGGGGSSAFTSFLPPRPLVHPLTGKALDPASPLGLALAARERALKESSEGGGAPQPPPRPPSPRYEAPPPTPHHHSPHAHHEPVLRLWGASPPDPARRELGYRAGLGSQEKSLPASPPAARRSLLHRLPPTAPGVGPLLLQLGTEPPAPHPGVSKPWRSAAPEEPERLPLHVRFLENCQPRAPVTSGRGPPSEDGPGVPPPSPRRSVPPSPTSPRASEENGLPLLVLPPPAPSVDVEDGEFLFVEPLPPPLEFSNSFEKPESPLTPGPPHPLPDTPAPATPLPPVPPPAVAAAPPTLDSTASSLTSYDSEVATLTQGASAAPGDPHPPGPPAPAAPAPAAPQPGPDPPPGTDSGIEEVDSRSSSDHPLETISSASTLSSLSAEGGGSAGGGGGAGAGVASGPELLDTYVAYLDGQAFGGSSTPGPPYPPQLMTPSKLRGRALGASGGLRPGPSGGLRDPVTPTSPTVSVTGAGTDGLLALRACSGPPTAGVAGGPVAVEPEVPPVPLPTASSLPRKLLPWEEGPGPPPPPLPGPLAQPQASALATVKASIISELSSKLQQFGGSSAAGGALPWARGGSGGGGDSHHGGASYVPERTSSLQRQRLSDDSQSSLLSKPVSSLFQNWPKPPLPPLPTGTGVSPTAAAAPGATSPSASSSSTSTRHLQGVEFEMRPPLLRRAPSPSLLPASEHKVSPAPRPSSLPILPSGPLYPGLFDIRGSPTGGAGGSADPFAPVFVPPHPGISGGLGGALSGASRSLSPTRLLSLPPDKPFGAKPLGFWTKFDVADWLEWLGLAEHRAQFLDHEIDGSHLPALTKEDYVDLGVTRVGHRMNIDRALKFFLER

Target ORF information:

RefSeq Version	XM_006723233.3
Organism	Homo sapiens(Human)
Definition	Homo sapiens SH3 and multiple ankyrin repeat domains 1 (SHANK1), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006723233.3

ORF Insert Sequence:

ATGACCCACA GCCCCGCGAC AAGCGAGGAC GAGGAACGCC ACAGTGCCAG CGAGTGTCCC 
GAGGGGGGCT CAGAGTCCGA CAGCTCCCCA GACGGGCCAG GTCGAGGCCC CCGGGGGACC 
CGGGGCCAGG GCAGTGGGGC ACCTGGTAGC CTGGCCTCTG TTAGAGGCCT CCAGGGCCGC 
TCAATGTCCG TCCCAGACGA CGCCCACTTC AGCATGATGG TCTTCAGGAT TGGCATCCCG 
GACCTGCACC AGACAAAATG CCTTCGCTTC AACCCCGATG CCACCATCTG GACGGCCAAG 
CAGCAGGTGC TCTGTGCCCT GAGCGAGAGC CTGCAGGATG TGCTCAACTA TGGCCTGTTC 
CAACCGGCCA CCTCCGGCCG CGATGCCAAC TTCCTGGAGG AGGAGAGGCT GCTGCGGGAG 
TACCCCCAGT CCTTTGAGAA GGGGGTCCCC TACCTGGAGT TCCGATACAA GACCCGAGTT 
TACAAACAGA CCAACCTGGA TGAGAAGCAG CTGGCCAAGT TGCACACGAA GACGGGGTTG 
AAGAAGTTCC TGGAGTATGT GCAGCTCGGG ACATCTGACA AGGTGGCGCG GCTGCTGGAC 
AAGGGGCTGG ACCCCAATTA CCATGACTCG GATTCGGGAG AGACCCCCTT GACACTGGCG 
GCCCAGACCG AAGGCTCTGT AGAGGTGATT CGAACCCTGT GCCTGGGCGG GGCCCACATT 
GACTTCCGGG CCCGGGATGG CATGACCGCA CTGCATAAGG CCGCATGCGC CCGACACTGC 
CTGGCACTCA CGGCGCTCCT GGACCTTGGG GGTTCCCCCA ACTACAAGGA CCGTCGGGGG 
CTGACCCCTC TGTTCCACAC GGCCATGGTG GGTGGTGACC CCCGATGCTG CGAGCTGCTC 
CTGTTCAACA GGGCCCAGCT GGGCATAGCT GATGAGAACG GCTGGCAGGA AATCCACCAG 
GCCTGCCAGC GGGGTCACTC TCAGCACCTG GAGCATCTGC TTTTCTACGG GGCTGAGCCT 
GGAGCCCAGA ACGCCTCGGG GAACACGGCT CTGCACATCT GCGCCCTCTA CAACAAGGAG 
ACCTGTGCCA GGATCCTCCT GTATCGAGGT GCCGACAAGG ATGTGAAGAA CAACAACGGA 
CAGACCCCCT TCCAGGTGGC AGTGATTGCT GGGAATTTTG AGCTGGGGGA GCTGATCCGA 
AACCACCGAG AACAGGATGT GGTGCCCTTC CAGGAGTCCC CCAAGTACGC GGCCCGGCGA 
CGGGGGCCCC CAGGCACAGG GCTGACGGTG CCCCCGGCGC TGCTGCGGGC CAACAGTGAC 
ACCAGCATGG CGCTGCCCGA CTGGATGGTG TTCTCCGCCC CGGGGGCCGC GTCCTCTGGG 
GCCCCTGGCC CTACCTCAGG GTCCCAGGGC CAGTCGCAGC CCTCGGCCCC CACCACCAAG 
CTCAGCAGCG GGACCCTCCG AAGTGCCAGC AGCCCCCGGG GTGCCAGGGC CCGCTCTCCA 
TCCCGAGGGA GGCACCCTGA GGACGCCAAG AGGCAGCCCC GAGGCCGGCC CAGCTCCAGC 
GGGACACCCC GGGAAGGGCC AGCCGGGGGC ACGGGGGGCT CAGGGGGCCC CGGGGGCTCC 
CTGGGCAGCC GCGGGAGGCG GAGGAAGCTC TACTCAGCGG TACCCGGACG CTCCTTCATG 
GCTGTGAAGT CCTACCAGGC CCAAGCCGAG GGGGAGATCT CCCTGAGCAA GGGCGAGAAG 
ATCAAAGTAC TTAGCATCGG GGAAGGAGGC TTCTGGGAAG GCCAGGTCAA AGGTCGTGTT 
GGCTGGTTCC CCTCTGACTG CCTGGAAGAA GTGGCGAATC GCTCTCAGGA GAGCAAGCAA 
GAAAGCCGCA GTGACAAGGC AAAGAGACTC TTCCGGCATT ATACCGTGGG CTCCTACGAC 
AGCTTTGATG CCCCAAGCTT AATGGATGGG ATTGGCCCAG GGAGCGATTA CATCATTAAG 
GAGAAGACAG TCTTGCTGCA GAAGAAGGAC AGTGAGGGGT TTGGGTTCGT GCTCCGGGGG 
GCCAAGGCGC AGACCCCCAT CGAGGAGTTC ACCCCCACCC CGGCCTTCCC GGCGCTGCAG 
TACCTGGAGT CGGTGGACGA GGGTGGCGTG GCATGGCGAG CTGGACTGCG AATGGGAGAC 
TTCCTCATCG AGGTGAACGG GCAGAATGTG GTGAAGGTCG GCCACCGACA GGTGGTGAAC 
ATGATCCGCC AAGGGGGCAA CACGCTGATG GTGAAGGTGG TGATGGTCAC CAGGCACCCG 
GACATGGATG AGGCAGTGCA CAAGAAAGCA CCCCAGCAGG CCAAGCGGCT GCCGCCCCCA 
ACCATCTCCC TGCGTTCCAA ATCTATGACC TCAGAGCTGG AGGAGATGGA GTACGAGCAG 
CAGCCGGCGC CGGTGCCCAG CATGGAGAAA AAGCGGACCG TGTATCAGAT GGCTCTCAAC 
AAACTGGACG AAATCCTGGC CGCAGCTCAA CAGACCATCA GTGCAAGCGA AAGCCCTGGT 
CCCGGTGGCC TCGCGTCCCT GGGCAAACAC CGACCCAAAG GTTTCTTTGC CACTGAGTCG 
AGCTTCGATC CCCACCACCG TGCCCAGCCA AGTTACGAGC GTCCTTCTTT CCTGCCTCCA 
GGACCTGGGT TGATGCTCCG GCAAAAATCT ATCGGTGCGG CAGAAGATGA CAGACCTTAC 
CTAGCACCCC CAGCCATGAA ATTCAGCCGC AGCCTGTCTG TGCCTGGTTC GGAGGACATT 
CCCCCGCCAC CCACCACGTC CCCACCGGAG CCTCCCTACA GCACACCTCC AGTCCCCTCC 
TCCTCAGGGC GCCTCACCCC CTCCCCTCGG GGAGGGCCCT TCAACCCTGG CTCTGGTGGC 
CCCCTCCCCG CCTCCTCCCC TGCATCCTTT GACGGGCCCT CCCCTCCCGA CACTCGCGTG 
GGGAGCCGCG AGAAGAGCCT GTACCACAGT GGGCCCCTGC CCCCGGCCCA CCACCACCCG 
CCCCACCACC ACCACCACCA CGCCCCGCCC CCTCAGCCCC ACCACCACCA CGCCCACCCC 
CCTCATCCTC CCGAGATGGA GACAGGCGGC TCTCCCGACG ACCCTCCACC CCGCCTGGCT 
CTGGGGCCCC AGCCCAGCCT GCGAGGCTGG AGGGGCGGCG GGCCCAGCCC GACCCCGGGG 
GCCCCGTCCC CATCGCACCA CGGCAGCGCG GGCGGGGGCG GCGGCTCCTC CCAGGGCCCG 
GCTCTACGCT ATTTCCAGCT GCCCCCGCGG GCGGCCAGCG CAGCCATGTA CGTGCCCGCC 
CGCTCGGGCC GCGGCCGCAA GGGCCCGCTG GTCAAGCAGA CCAAGGTGGA AGGCGAGCCC 
CAGAAGGGCG GCGGCCTCCC GCCCGCGCCG TCGCCCACGT CCCCGGCCTC CCCGCAGCCG 
CCGCCCGCCG TGGCCGCGCC CTCGGAGAAG AACTCCATCC CCATCCCCAC CATCATCATC 
AAGGCCCCGT CCACCAGTAG CAGCGGCCGC AGCAGCCAGG GCAGCAGCAC CGAGGCGGAG 
CCCCCCACCC AGCCGGAGCC CACGGGAGGC GGCGGCGGCG GCGGCTCCTC GCCCAGCCCC 
GCCCCGGCCA TGTCACCCGT GCCCCCGTCC CCCTCGCCCG TGCCCACCCC CGCCTCGCCC 
AGCGGCCCGG CCACGCTGGA CTTCACGAGC CAGTTCGGGG CCGCCCTGGT GGGGGCGGCC 
CGGAGGGAGG GGGGCTGGCA GAATGAGGCG CGCCGGCGCT CCACGCTGTT CCTGTCCACC 
GACGCGGGGG ACGAGGACGG CGGGGACGGC GGGCTGGGCA CAGGGGCGGC CCCGGGCCCG 
CGGCTGCGCC ACTCCAAATC CATCGACGAG GGCATGTTCT CCGCCGAGCC CTACCTCCGA 
CTGGAGTCTG CGGGCAGCGG CGCGGGCTAC GGCGGCTACG GGGCCGGTAG CCGAGCCTAC 
GGGGGTGGCG GGGGCAGCAG CGCCTTCACC AGCTTCCTGC CCCCGCGACC CCTGGTGCAC 
CCGCTGACCG GCAAGGCCCT GGATCCCGCC TCCCCGCTGG GGCTGGCCCT GGCCGCCCGC 
GAGCGAGCGC TGAAGGAGTC CTCGGAGGGC GGCGGGGCCC CCCAGCCGCC TCCCAGGCCC 
CCATCGCCCC GCTACGAGGC CCCGCCGCCC ACCCCGCACC ACCACTCGCC CCACGCCCAC 
CACGAGCCAG TGCTGCGTCT CTGGGGGGCC TCCCCGCCGG ACCCTGCGCG CCGGGAGCTG 
GGGTACAGGG CCGGGCTGGG CAGCCAGGAG AAGTCCCTTC CCGCCAGCCC GCCCGCCGCC 
CGGCGTTCCC TGCTACACCG CCTGCCGCCC ACCGCTCCCG GGGTGGGGCC CCTCCTGCTG 
CAGCTGGGGA CGGAGCCCCC GGCCCCGCAC CCCGGAGTAA GCAAGCCCTG GAGGTCCGCA 
GCCCCCGAAG AACCCGAGCG GCTGCCGCTG CACGTGCGGT TCCTTGAAAA CTGCCAGCCC 
CGGGCCCCTG TGACGAGCGG AAGGGGTCCC CCCTCGGAGG ACGGGCCGGG GGTCCCGCCG 
CCCAGCCCAC GCCGGTCCGT GCCCCCCTCC CCGACCTCCC CGAGGGCCAG CGAAGAGAAC 
GGGCTGCCCC TGCTGGTCCT GCCGCCTCCC GCCCCCTCGG TGGATGTGGA AGATGGCGAA 
TTCCTTTTCG TGGAACCGCT GCCTCCGCCT CTGGAATTCT CCAACAGCTT CGAAAAGCCA 
GAGTCGCCCC TCACGCCTGG GCCTCCCCAC CCGCTGCCCG ACACACCTGC CCCTGCCACC 
CCGTTACCCC CTGTGCCACC CCCGGCTGTG GCCGCAGCCC CTCCCACCCT GGACTCCACC 
GCATCCAGCC TGACATCCTA TGACAGCGAG GTGGCCACCC TGACCCAGGG GGCCTCCGCC 
GCTCCTGGGG ACCCCCATCC ACCAGGCCCG CCTGCCCCAG CAGCACCGGC TCCCGCTGCC 
CCACAGCCTG GCCCGGACCC TCCGCCTGGC ACGGATTCTG GCATCGAGGA GGTGGACAGT 
CGGAGCAGCA GTGACCACCC ACTGGAGACC ATCAGCAGCG CCTCCACGCT GAGCAGCCTA 
TCTGCCGAAG GTGGTGGCAG CGCAGGGGGT GGGGGCGGGG CTGGGGCCGG TGTGGCCAGT 
GGGCCGGAGC TTCTGGACAC CTATGTGGCC TACCTGGACG GCCAGGCCTT TGGGGGCAGC 
AGTACTCCCG GCCCGCCATA CCCTCCTCAG CTCATGACTC CCTCTAAGCT CCGGGGCCGG 
GCGCTAGGAG CCAGCGGAGG CCTGCGGCCT GGCCCCAGCG GGGGACTCCG AGACCCTGTT 
ACCCCCACCA GCCCCACCGT CTCGGTGACA GGGGCTGGAA CCGATGGGCT GCTGGCCCTG 
CGTGCTTGTT CAGGACCCCC CACGGCAGGC GTGGCGGGGG GTCCGGTGGC TGTAGAGCCA 
GAAGTCCCAC CGGTGCCCTT GCCGACGGCC TCCTCTCTGC CCCGGAAGCT GCTGCCCTGG 
GAGGAGGGCC CGGGCCCACC GCCACCACCT CTGCCCGGGC CCTTGGCCCA GCCTCAGGCC 
TCAGCCTTGG CCACAGTAAA AGCCAGCATC ATCAGTGAAC TCAGCTCCAA GCTTCAGCAG 
TTTGGGGGCT CCTCGGCAGC TGGCGGCGCT CTGCCCTGGG CCCGAGGAGG CAGTGGGGGA 
GGCGGAGACA GCCACCACGG GGGAGCCAGC TATGTCCCCG AGAGGACCTC CTCCCTGCAG 
CGGCAGAGAC TCTCCGACGA CTCCCAGTCC TCACTCCTCT CCAAGCCTGT CAGCAGCCTG 
TTTCAGAACT GGCCCAAACC ACCTCTGCCG CCACTCCCCA CCGGAACAGG GGTCTCCCCT 
ACAGCCGCTG CGGCCCCAGG GGCCACCTCA CCCTCAGCCT CCTCCTCCTC CACGTCCACC 
CGCCACCTCC AGGGCGTGGA GTTCGAGATG CGGCCCCCTC TGCTCCGCCG GGCCCCCAGC 
CCCTCGCTGC TGCCCGCCTC GGAGCACAAG GTCAGCCCTG CGCCCAGGCC CTCGTCCCTG 
CCCATCCTGC CTTCCGGACC CCTCTACCCA GGCCTCTTTG ACATCCGTGG CTCCCCAACT 
GGAGGGGCAG GAGGCTCGGC TGACCCCTTC GCCCCAGTCT TTGTGCCGCC ACACCCGGGG 
ATATCCGGGG GGCTCGGGGG AGCCTTGTCA GGGGCCTCGC GCTCCCTCTC ACCGACCCGC 
CTGCTCTCGC TGCCCCCGGA CAAGCCGTTT GGCGCTAAAC CTCTGGGGTT CTGGACCAAG 
TTCGACGTGG CTGATTGGCT GGAGTGGCTG GGTTTGGCGG AGCACCGAGC CCAGTTCCTG 
GACCACGAGA TCGATGGCTC CCACCTGCCC GCCTTGACCA AGGAGGACTA CGTCGATCTA 
GGTGTGACCA GGGTGGGCCA CCGCATGAAC ATCGACCGGG CTCTCAAATT CTTCCTGGAG 
AGGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SHANK1 ( XM_011527013.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_011525315.1 Homo sapiens SH3 and multiple ankyrin repeat domains 1 (SHANK1), transcript variant X1, mRNA.

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CloneID	OHu52292
Clone ID Related Accession (Same CDS sequence)	XM_011527013.2
Accession Version	XM_011527013.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 6510bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	SH3 and multiple ankyrin repeat domains protein 1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000019.10) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011527013.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGACCCACA GCCCCGCGAC AAGCGAGGAC GAGGAACGCC ACAGTGCCAG CGAGTGTCCC 
GAGGGGGGCT CAGAGTCCGA CAGCTCCCCA GACGGGCCAG GTCGAGGCCC CCGGGGGACC 
CGGGGCCAGG GCAGTGGGGC ACCTGGTAGC CTGGCCTCTG TTAGAGGCCT CCAGGGCCGC 
TCAATGTCCG TCCCAGACGA CGCCCACTTC AGCATGATGG TCTTCAGGAT TGGCATCCCG 
GACCTGCACC AGACAAAATG CCTTCGCTTC AACCCCGATG CCACCATCTG GACGGCCAAG 
CAGCAGGTGC TCTGTGCCCT GAGCGAGAGC CTGCAGGATG TGCTCAACTA TGGCCTGTTC 
CAACCGGCCA CCTCCGGCCG CGATGCCAAC TTCCTGGAGG AGGAGAGGCT GCTGCGGGAG 
TACCCCCAGT CCTTTGAGAA GGGGGTCCCC TACCTGGAGT TCCGATACAA GACCCGAGTT 
TACAAACAGA CCAACCTGGA TGAGAAGCAG CTGGCCAAGT TGCACACGAA GACGGGGTTG 
AAGAAGTTCC TGGAGTATGT GCAGCTCGGG ACATCTGACA AGGTGGCGCG GCTGCTGGAC 
AAGGGGCTGG ACCCCAATTA CCATGACTCG GATTCGGGAG AGACCCCCTT GACACTGGCG 
GCCCAGACCG AAGGCTCTGT AGAGGTGATT CGAACCCTGT GCCTGGGCGG GGCCCACATT 
GACTTCCGGG CCCGGGATGG CATGACCGCA CTGCATAAGG CCGCATGCGC CCGACACTGC 
CTGGCACTCA CGGCGCTCCT GGACCTTGGG GGTTCCCCCA ACTACAAGGA CCGTCGGGGG 
CTGACCCCTC TGTTCCACAC GGCCATGGTG GGTGGTGACC CCCGATGCTG CGAGCTGCTC 
CTGTTCAACA GGGCCCAGCT GGGCATAGCT GATGAGAACG GCTGGCAGGA AATCCACCAG 
GCCTGCCAGC GGGGTCACTC TCAGCACCTG GAGCATCTGC TTTTCTACGG GGCTGAGCCT 
GGAGCCCAGA ACGCCTCGGG GAACACGGCT CTGCACATCT GCGCCCTCTA CAACAAGGAG 
ACCTGTGCCA GGATCCTCCT GTATCGAGGT GCCGACAAGG ATGTGAAGAA CAACAACGGA 
CAGACCCCCT TCCAGGTGGC AGTGATTGCT GGGAATTTTG AGCTGGGGGA GCTGATCCGA 
AACCACCGAG AACAGGATGT GGTGCCCTTC CAGGAGTCCC CCAAGTACGC GGCCCGGCGA 
CGGGGGCCCC CAGGCACAGG GCTGACGGTG CCCCCGGCGC TGCTGCGGGC CAACAGTGAC 
ACCAGCATGG CGCTGCCCGA CTGGATGGTG TTCTCCGCCC CGGGGGCCGC GTCCTCTGGG 
GCCCCTGGCC CTACCTCAGG GTCCCAGGGC CAGTCGCAGC CCTCGGCCCC CACCACCAAG 
CTCAGCAGCG GGACCCTCCG AAGTGCCAGC AGCCCCCGGG GTGCCAGGGC CCGCTCTCCA 
TCCCGAGGGA GGCACCCTGA GGACGCCAAG AGGCAGCCCC GAGGCCGGCC CAGCTCCAGC 
GGGACACCCC GGGAAGGGCC AGCCGGGGGC ACGGGGGGCT CAGGGGGCCC CGGGGGCTCC 
CTGGGCAGCC GCGGGAGGCG GAGGAAGCTC TACTCAGCGG TACCCGGACG CTCCTTCATG 
GCTGTGAAGT CCTACCAGGC CCAAGCCGAG GGGGAGATCT CCCTGAGCAA GGGCGAGAAG 
ATCAAAGTAC TTAGCATCGG GGAAGGAGGC TTCTGGGAAG GCCAGGTCAA AGGTCGTGTT 
GGCTGGTTCC CCTCTGACTG CCTGGAAGAA GTGGCGAATC GCTCTCAGGA GAGCAAGCAA 
GAAAGCCGCA GTGACAAGGC AAAGAGACTC TTCCGGCATT ATACCGTGGG CTCCTACGAC 
AGCTTTGATG CCCCAAGCTT AATGGATGGG ATTGGCCCAG GGAGCGATTA CATCATTAAG 
GAGAAGACAG TCTTGCTGCA GAAGAAGGAC AGTGAGGGGT TTGGGTTCGT GCTCCGGGGG 
GCCAAGGCGC AGACCCCCAT CGAGGAGTTC ACCCCCACCC CGGCCTTCCC GGCGCTGCAG 
TACCTGGAGT CGGTGGACGA GGGTGGCGTG GCATGGCGAG CTGGACTGCG AATGGGAGAC 
TTCCTCATCG AGGTGAACGG GCAGAATGTG GTGAAGGTCG GCCACCGACA GGTGGTGAAC 
ATGATCCGCC AAGGGGGCAA CACGCTGATG GTGAAGGTGG TGATGGTCAC CAGGCACCCG 
GACATGGATG AGGCAGTGCA CAAGAAAGCA CCCCAGCAGG CCAAGCGGCT GCCGCCCCCA 
ACCATCTCCC TGCGTTCCAA ATCTATGACC TCAGAGCTGG AGGAGATGGT CTCCCCCTGG 
AAGAAGAAGA GTGAGTACGA GCAGCAGCCG GCGCCGGTGC CCAGCATGGA GAAAAAGCGG 
ACCGTGTATC AGATGGCTCT CAACAAACTG GACGAAATCC TGGCCGCAGC TCAACAGACC 
ATCAGTGCAA GCGAAAGCCC TGGTCCCGGT GGCCTCGCGT CCCTGGGCAA ACACCGACCC 
AAAGGTTTCT TTGCCACTGA GTCGAGCTTC GATCCCCACC ACCGTGCCCA GCCAAGTTAC 
GAGCGTCCTT CTTTCCTGCC TCCAGGACCT GGGTTGATGC TCCGGCAAAA ATCTATCGGT 
GCGGCAGAAG ATGACAGACC TTACCTAGCA CCCCCAGCCA TGAAATTCAG CCGCAGCCTG 
TCTGTGCCTG GTTCGGAGGA CATTCCCCCG CCACCCACCA CGTCCCCACC GGAGCCTCCC 
TACAGCACAC CTCCAGTCCC CTCCTCCTCA GGGCGCCTCA CCCCCTCCCC TCGGGGAGGG 
CCCTTCAACC CTGGCTCTGG TGGCCCCCTC CCCGCCTCCT CCCCTGCATC CTTTGACGGG 
CCCTCCCCTC CCGACACTCG CGTGGGGAGC CGCGAGAAGA GCCTGTACCA CAGTGGGCCC 
CTGCCCCCGG CCCACCACCA CCCGCCCCAC CACCACCACC ACCACGCCCC GCCCCCTCAG 
CCCCACCACC ACCACGCCCA CCCCCCTCAT CCTCCCGAGA TGGAGACAGG CGGCTCTCCC 
GACGACCCTC CACCCCGCCT GGCTCTGGGG CCCCAGCCCA GCCTGCGAGG CTGGAGGGGC 
GGCGGGCCCA GCCCGACCCC GGGGGCCCCG TCCCCATCGC ACCACGGCAG CGCGGGCGGG 
GGCGGCGGCT CCTCCCAGGG CCCGGCTCTA CGCTATTTCC AGCTGCCCCC GCGGGCGGCC 
AGCGCAGCCA TGTACGTGCC CGCCCGCTCG GGCCGCGGCC GCAAGGGCCC GCTGGTCAAG 
CAGACCAAGG TGGAAGGCGA GCCCCAGAAG GGCGGCGGCC TCCCGCCCGC GCCGTCGCCC 
ACGTCCCCGG CCTCCCCGCA GCCGCCGCCC GCCGTGGCCG CGCCCTCGGA GAAGAACTCC 
ATCCCCATCC CCACCATCAT CATCAAGGCC CCGTCCACCA GTAGCAGCGG CCGCAGCAGC 
CAGGGCAGCA GCACCGAGGC GGAGCCCCCC ACCCAGCCGG AGCCCACGGG AGGCGGCGGC 
GGCGGCGGCT CCTCGCCCAG CCCCGCCCCG GCCATGTCAC CCGTGCCCCC GTCCCCCTCG 
CCCGTGCCCA CCCCCGCCTC GCCCAGCGGC CCGGCCACGC TGGACTTCAC GAGCCAGTTC 
GGGGCCGCCC TGGTGGGGGC GGCCCGGAGG GAGGGGGGCT GGCAGAATGA GGCGCGCCGG 
CGCTCCACGC TGTTCCTGTC CACCGACGCG GGGGACGAGG ACGGCGGGGA CGGCGGGCTG 
GGCACAGGGG CGGCCCCGGG CCCGCGGCTG CGCCACTCCA AATCCATCGA CGAGGGCATG 
TTCTCCGCCG AGCCCTACCT CCGACTGGAG TCTGCGGGCA GCGGCGCGGG CTACGGCGGC 
TACGGGGCCG GTAGCCGAGC CTACGGGGGT GGCGGGGGCA GCAGCGCCTT CACCAGCTTC 
CTGCCCCCGC GACCCCTGGT GCACCCGCTG ACCGGCAAGG CCCTGGATCC CGCCTCCCCG 
CTGGGGCTGG CCCTGGCCGC CCGCGAGCGA GCGCTGAAGG AGTCCTCGGA GGGCGGCGGG 
GCCCCCCAGC CGCCTCCCAG GCCCCCATCG CCCCGCTACG AGGCCCCGCC GCCCACCCCG 
CACCACCACT CGCCCCACGC CCACCACGAG CCAGTGCTGC GTCTCTGGGG GGCCTCCCCG 
CCGGACCCTG CGCGCCGGGA GCTGGGGTAC AGGGCCGGGC TGGGCAGCCA GGAGAAGTCC 
CTTCCCGCCA GCCCGCCCGC CGCCCGGCGT TCCCTGCTAC ACCGCCTGCC GCCCACCGCT 
CCCGGGGTGG GGCCCCTCCT GCTGCAGCTG GGGACGGAGC CCCCGGCCCC GCACCCCGGA 
GTAAGCAAGC CCTGGAGGTC CGCAGCCCCC GAAGAACCCG AGCGGCTGCC GCTGCACGTG 
CGGTTCCTTG AAAACTGCCA GCCCCGGGCC CCTGTGACGA GCGGAAGGGG TCCCCCCTCG 
GAGGACGGGC CGGGGGTCCC GCCGCCCAGC CCACGCCGGT CCGTGCCCCC CTCCCCGACC 
TCCCCGAGGG CCAGCGAAGA GAACGGGCTG CCCCTGCTGG TCCTGCCGCC TCCCGCCCCC 
TCGGTGGATG TGGAAGATGG CGAATTCCTT TTCGTGGAAC CGCTGCCTCC GCCTCTGGAA 
TTCTCCAACA GCTTCGAAAA GCCAGAGTCG CCCCTCACGC CTGGGCCTCC CCACCCGCTG 
CCCGACACAC CTGCCCCTGC CACCCCGTTA CCCCCTGTGC CACCCCCGGC TGTGGCCGCA 
GCCCCTCCCA CCCTGGACTC CACCGCATCC AGCCTGACAT CCTATGACAG CGAGGTGGCC 
ACCCTGACCC AGGGGGCCTC CGCCGCTCCT GGGGACCCCC ATCCACCAGG CCCGCCTGCC 
CCAGCAGCAC CGGCTCCCGC TGCCCCACAG CCTGGCCCGG ACCCTCCGCC TGGCACGGAT 
TCTGGCATCG AGGAGGTGGA CAGTCGGAGC AGCAGTGACC ACCCACTGGA GACCATCAGC 
AGCGCCTCCA CGCTGAGCAG CCTATCTGCC GAAGGTGGTG GCAGCGCAGG GGGTGGGGGC 
GGGGCTGGGG CCGGTGTGGC CAGTGGGCCG GAGCTTCTGG ACACCTATGT GGCCTACCTG 
GACGGCCAGG CCTTTGGGGG CAGCAGTACT CCCGGCCCGC CATACCCTCC TCAGCTCATG 
ACTCCCTCTA AGCTCCGGGG CCGGGCGCTA GGAGCCAGCG GAGGCCTGCG GCCTGGCCCC 
AGCGGGGGAC TCCGAGACCC TGTTACCCCC ACCAGCCCCA CCGTCTCGGT GACAGGGGCT 
GGAACCGATG GGCTGCTGGC CCTGCGTGCT TGTTCAGGAC CCCCCACGGC AGGCGTGGCG 
GGGGGTCCGG TGGCTGTAGA GCCAGAAGTC CCACCGGTGC CCTTGCCGAC GGCCTCCTCT 
CTGCCCCGGA AGCTGCTGCC CTGGGAGGAG GGCCCGGGCC CACCGCCACC ACCTCTGCCC 
GGGCCCTTGG CCCAGCCTCA GGCCTCAGCC TTGGCCACAG TAAAAGCCAG CATCATCAGT 
GAACTCAGCT CCAAGCTTCA GCAGTTTGGG GGCTCCTCGG CAGCTGGCGG CGCTCTGCCC 
TGGGCCCGAG GAGGCAGTGG GGGAGGCGGA GACAGCCACC ACGGGGGAGC CAGCTATGTC 
CCCGAGAGGA CCTCCTCCCT GCAGCGGCAG AGACTCTCCG ACGACTCCCA GTCCTCACTC 
CTCTCCAAGC CTGTCAGCAG CCTGTTTCAG AACTGGCCCA AACCACCTCT GCCGCCACTC 
CCCACCGGAA CAGGGGTCTC CCCTACAGCC GCTGCGGCCC CAGGGGCCAC CTCACCCTCA 
GCCTCCTCCT CCTCCACGTC CACCCGCCAC CTCCAGGGCG TGGAGTTCGA GATGCGGCCC 
CCTCTGCTCC GCCGGGCCCC CAGCCCCTCG CTGCTGCCCG CCTCGGAGCA CAAGGTCAGC 
CCTGCGCCCA GGCCCTCGTC CCTGCCCATC CTGCCTTCCG GACCCCTCTA CCCAGGCCTC 
TTTGACATCC GTGGCTCCCC AACTGGAGGG GCAGGAGGCT CGGCTGACCC CTTCGCCCCA 
GTCTTTGTGC CGCCACACCC GGGGATATCC GGGGGGCTCG GGGGAGCCTT GTCAGGGGCC 
TCGCGCTCCC TCTCACCGAC CCGCCTGCTC TCGCTGCCCC CGGACAAGCC GTTTGGCGCT 
AAACCTCTGG GGTTCTGGAC CAAGTTCGAC GTGGCTGATT GGCTGGAGTG GCTGGGTTTG 
GCGGAGCACC GAGCCCAGTT CCTGGACCAC GAGATCGATG GCTCCCACCT GCCCGCCTTG 
ACCAAGGAGG ACTACGTCGA TCTAGGTGTG ACCAGGGTGG GCCACCGCAT GAACATCGAC 
CGGGCTCTCA AATTCTTCCT GGAGAGGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011525315.1
CDS	418..6927
Translation	MTHSPATSEDEERHSASECPEGGSESDSSPDGPGRGPRGTRGQGSGAPGSLASVRGLQGRSMSVPDDAHFSMMVFRIGIPDLHQTKCLRFNPDATIWTAKQQVLCALSESLQDVLNYGLFQPATSGRDANFLEEERLLREYPQSFEKGVPYLEFRYKTRVYKQTNLDEKQLAKLHTKTGLKKFLEYVQLGTSDKVARLLDKGLDPNYHDSDSGETPLTLAAQTEGSVEVIRTLCLGGAHIDFRARDGMTALHKAACARHCLALTALLDLGGSPNYKDRRGLTPLFHTAMVGGDPRCCELLLFNRAQLGIADENGWQEIHQACQRGHSQHLEHLLFYGAEPGAQNASGNTALHICALYNKETCARILLYRGADKDVKNNNGQTPFQVAVIAGNFELGELIRNHREQDVVPFQESPKYAARRRGPPGTGLTVPPALLRANSDTSMALPDWMVFSAPGAASSGAPGPTSGSQGQSQPSAPTTKLSSGTLRSASSPRGARARSPSRGRHPEDAKRQPRGRPSSSGTPREGPAGGTGGSGGPGGSLGSRGRRRKLYSAVPGRSFMAVKSYQAQAEGEISLSKGEKIKVLSIGEGGFWEGQVKGRVGWFPSDCLEEVANRSQESKQESRSDKAKRLFRHYTVGSYDSFDAPSLMDGIGPGSDYIIKEKTVLLQKKDSEGFGFVLRGAKAQTPIEEFTPTPAFPALQYLESVDEGGVAWRAGLRMGDFLIEVNGQNVVKVGHRQVVNMIRQGGNTLMVKVVMVTRHPDMDEAVHKKAPQQAKRLPPPTISLRSKSMTSELEEMVSPWKKKSEYEQQPAPVPSMEKKRTVYQMALNKLDEILAAAQQTISASESPGPGGLASLGKHRPKGFFATESSFDPHHRAQPSYERPSFLPPGPGLMLRQKSIGAAEDDRPYLAPPAMKFSRSLSVPGSEDIPPPPTTSPPEPPYSTPPVPSSSGRLTPSPRGGPFNPGSGGPLPASSPASFDGPSPPDTRVGSREKSLYHSGPLPPAHHHPPHHHHHHAPPPQPHHHHAHPPHPPEMETGGSPDDPPPRLALGPQPSLRGWRGGGPSPTPGAPSPSHHGSAGGGGGSSQGPALRYFQLPPRAASAAMYVPARSGRGRKGPLVKQTKVEGEPQKGGGLPPAPSPTSPASPQPPPAVAAPSEKNSIPIPTIIIKAPSTSSSGRSSQGSSTEAEPPTQPEPTGGGGGGGSSPSPAPAMSPVPPSPSPVPTPASPSGPATLDFTSQFGAALVGAARREGGWQNEARRRSTLFLSTDAGDEDGGDGGLGTGAAPGPRLRHSKSIDEGMFSAEPYLRLESAGSGAGYGGYGAGSRAYGGGGGSSAFTSFLPPRPLVHPLTGKALDPASPLGLALAARERALKESSEGGGAPQPPPRPPSPRYEAPPPTPHHHSPHAHHEPVLRLWGASPPDPARRELGYRAGLGSQEKSLPASPPAARRSLLHRLPPTAPGVGPLLLQLGTEPPAPHPGVSKPWRSAAPEEPERLPLHVRFLENCQPRAPVTSGRGPPSEDGPGVPPPSPRRSVPPSPTSPRASEENGLPLLVLPPPAPSVDVEDGEFLFVEPLPPPLEFSNSFEKPESPLTPGPPHPLPDTPAPATPLPPVPPPAVAAAPPTLDSTASSLTSYDSEVATLTQGASAAPGDPHPPGPPAPAAPAPAAPQPGPDPPPGTDSGIEEVDSRSSSDHPLETISSASTLSSLSAEGGGSAGGGGGAGAGVASGPELLDTYVAYLDGQAFGGSSTPGPPYPPQLMTPSKLRGRALGASGGLRPGPSGGLRDPVTPTSPTVSVTGAGTDGLLALRACSGPPTAGVAGGPVAVEPEVPPVPLPTASSLPRKLLPWEEGPGPPPPPLPGPLAQPQASALATVKASIISELSSKLQQFGGSSAAGGALPWARGGSGGGGDSHHGGASYVPERTSSLQRQRLSDDSQSSLLSKPVSSLFQNWPKPPLPPLPTGTGVSPTAAAAPGATSPSASSSSTSTRHLQGVEFEMRPPLLRRAPSPSLLPASEHKVSPAPRPSSLPILPSGPLYPGLFDIRGSPTGGAGGSADPFAPVFVPPHPGISGGLGGALSGASRSLSPTRLLSLPPDKPFGAKPLGFWTKFDVADWLEWLGLAEHRAQFLDHEIDGSHLPALTKEDYVDLGVTRVGHRMNIDRALKFFLER

Target ORF information:

RefSeq Version	XM_011527013.2
Organism	Homo sapiens(human)
Definition	Homo sapiens SH3 and multiple ankyrin repeat domains 1 (SHANK1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011527013.2

ORF Insert Sequence:

ATGACCCACA GCCCCGCGAC AAGCGAGGAC GAGGAACGCC ACAGTGCCAG CGAGTGTCCC 
GAGGGGGGCT CAGAGTCCGA CAGCTCCCCA GACGGGCCAG GTCGAGGCCC CCGGGGGACC 
CGGGGCCAGG GCAGTGGGGC ACCTGGTAGC CTGGCCTCTG TTAGAGGCCT CCAGGGCCGC 
TCAATGTCCG TCCCAGACGA CGCCCACTTC AGCATGATGG TCTTCAGGAT TGGCATCCCG 
GACCTGCACC AGACAAAATG CCTTCGCTTC AACCCCGATG CCACCATCTG GACGGCCAAG 
CAGCAGGTGC TCTGTGCCCT GAGCGAGAGC CTGCAGGATG TGCTCAACTA TGGCCTGTTC 
CAACCGGCCA CCTCCGGCCG CGATGCCAAC TTCCTGGAGG AGGAGAGGCT GCTGCGGGAG 
TACCCCCAGT CCTTTGAGAA GGGGGTCCCC TACCTGGAGT TCCGATACAA GACCCGAGTT 
TACAAACAGA CCAACCTGGA TGAGAAGCAG CTGGCCAAGT TGCACACGAA GACGGGGTTG 
AAGAAGTTCC TGGAGTATGT GCAGCTCGGG ACATCTGACA AGGTGGCGCG GCTGCTGGAC 
AAGGGGCTGG ACCCCAATTA CCATGACTCG GATTCGGGAG AGACCCCCTT GACACTGGCG 
GCCCAGACCG AAGGCTCTGT AGAGGTGATT CGAACCCTGT GCCTGGGCGG GGCCCACATT 
GACTTCCGGG CCCGGGATGG CATGACCGCA CTGCATAAGG CCGCATGCGC CCGACACTGC 
CTGGCACTCA CGGCGCTCCT GGACCTTGGG GGTTCCCCCA ACTACAAGGA CCGTCGGGGG 
CTGACCCCTC TGTTCCACAC GGCCATGGTG GGTGGTGACC CCCGATGCTG CGAGCTGCTC 
CTGTTCAACA GGGCCCAGCT GGGCATAGCT GATGAGAACG GCTGGCAGGA AATCCACCAG 
GCCTGCCAGC GGGGTCACTC TCAGCACCTG GAGCATCTGC TTTTCTACGG GGCTGAGCCT 
GGAGCCCAGA ACGCCTCGGG GAACACGGCT CTGCACATCT GCGCCCTCTA CAACAAGGAG 
ACCTGTGCCA GGATCCTCCT GTATCGAGGT GCCGACAAGG ATGTGAAGAA CAACAACGGA 
CAGACCCCCT TCCAGGTGGC AGTGATTGCT GGGAATTTTG AGCTGGGGGA GCTGATCCGA 
AACCACCGAG AACAGGATGT GGTGCCCTTC CAGGAGTCCC CCAAGTACGC GGCCCGGCGA 
CGGGGGCCCC CAGGCACAGG GCTGACGGTG CCCCCGGCGC TGCTGCGGGC CAACAGTGAC 
ACCAGCATGG CGCTGCCCGA CTGGATGGTG TTCTCCGCCC CGGGGGCCGC GTCCTCTGGG 
GCCCCTGGCC CTACCTCAGG GTCCCAGGGC CAGTCGCAGC CCTCGGCCCC CACCACCAAG 
CTCAGCAGCG GGACCCTCCG AAGTGCCAGC AGCCCCCGGG GTGCCAGGGC CCGCTCTCCA 
TCCCGAGGGA GGCACCCTGA GGACGCCAAG AGGCAGCCCC GAGGCCGGCC CAGCTCCAGC 
GGGACACCCC GGGAAGGGCC AGCCGGGGGC ACGGGGGGCT CAGGGGGCCC CGGGGGCTCC 
CTGGGCAGCC GCGGGAGGCG GAGGAAGCTC TACTCAGCGG TACCCGGACG CTCCTTCATG 
GCTGTGAAGT CCTACCAGGC CCAAGCCGAG GGGGAGATCT CCCTGAGCAA GGGCGAGAAG 
ATCAAAGTAC TTAGCATCGG GGAAGGAGGC TTCTGGGAAG GCCAGGTCAA AGGTCGTGTT 
GGCTGGTTCC CCTCTGACTG CCTGGAAGAA GTGGCGAATC GCTCTCAGGA GAGCAAGCAA 
GAAAGCCGCA GTGACAAGGC AAAGAGACTC TTCCGGCATT ATACCGTGGG CTCCTACGAC 
AGCTTTGATG CCCCAAGCTT AATGGATGGG ATTGGCCCAG GGAGCGATTA CATCATTAAG 
GAGAAGACAG TCTTGCTGCA GAAGAAGGAC AGTGAGGGGT TTGGGTTCGT GCTCCGGGGG 
GCCAAGGCGC AGACCCCCAT CGAGGAGTTC ACCCCCACCC CGGCCTTCCC GGCGCTGCAG 
TACCTGGAGT CGGTGGACGA GGGTGGCGTG GCATGGCGAG CTGGACTGCG AATGGGAGAC 
TTCCTCATCG AGGTGAACGG GCAGAATGTG GTGAAGGTCG GCCACCGACA GGTGGTGAAC 
ATGATCCGCC AAGGGGGCAA CACGCTGATG GTGAAGGTGG TGATGGTCAC CAGGCACCCG 
GACATGGATG AGGCAGTGCA CAAGAAAGCA CCCCAGCAGG CCAAGCGGCT GCCGCCCCCA 
ACCATCTCCC TGCGTTCCAA ATCTATGACC TCAGAGCTGG AGGAGATGGT CTCCCCCTGG 
AAGAAGAAGA GTGAGTACGA GCAGCAGCCG GCGCCGGTGC CCAGCATGGA GAAAAAGCGG 
ACCGTGTATC AGATGGCTCT CAACAAACTG GACGAAATCC TGGCCGCAGC TCAACAGACC 
ATCAGTGCAA GCGAAAGCCC TGGTCCCGGT GGCCTCGCGT CCCTGGGCAA ACACCGACCC 
AAAGGTTTCT TTGCCACTGA GTCGAGCTTC GATCCCCACC ACCGTGCCCA GCCAAGTTAC 
GAGCGTCCTT CTTTCCTGCC TCCAGGACCT GGGTTGATGC TCCGGCAAAA ATCTATCGGT 
GCGGCAGAAG ATGACAGACC TTACCTAGCA CCCCCAGCCA TGAAATTCAG CCGCAGCCTG 
TCTGTGCCTG GTTCGGAGGA CATTCCCCCG CCACCCACCA CGTCCCCACC GGAGCCTCCC 
TACAGCACAC CTCCAGTCCC CTCCTCCTCA GGGCGCCTCA CCCCCTCCCC TCGGGGAGGG 
CCCTTCAACC CTGGCTCTGG TGGCCCCCTC CCCGCCTCCT CCCCTGCATC CTTTGACGGG 
CCCTCCCCTC CCGACACTCG CGTGGGGAGC CGCGAGAAGA GCCTGTACCA CAGTGGGCCC 
CTGCCCCCGG CCCACCACCA CCCGCCCCAC CACCACCACC ACCACGCCCC GCCCCCTCAG 
CCCCACCACC ACCACGCCCA CCCCCCTCAT CCTCCCGAGA TGGAGACAGG CGGCTCTCCC 
GACGACCCTC CACCCCGCCT GGCTCTGGGG CCCCAGCCCA GCCTGCGAGG CTGGAGGGGC 
GGCGGGCCCA GCCCGACCCC GGGGGCCCCG TCCCCATCGC ACCACGGCAG CGCGGGCGGG 
GGCGGCGGCT CCTCCCAGGG CCCGGCTCTA CGCTATTTCC AGCTGCCCCC GCGGGCGGCC 
AGCGCAGCCA TGTACGTGCC CGCCCGCTCG GGCCGCGGCC GCAAGGGCCC GCTGGTCAAG 
CAGACCAAGG TGGAAGGCGA GCCCCAGAAG GGCGGCGGCC TCCCGCCCGC GCCGTCGCCC 
ACGTCCCCGG CCTCCCCGCA GCCGCCGCCC GCCGTGGCCG CGCCCTCGGA GAAGAACTCC 
ATCCCCATCC CCACCATCAT CATCAAGGCC CCGTCCACCA GTAGCAGCGG CCGCAGCAGC 
CAGGGCAGCA GCACCGAGGC GGAGCCCCCC ACCCAGCCGG AGCCCACGGG AGGCGGCGGC 
GGCGGCGGCT CCTCGCCCAG CCCCGCCCCG GCCATGTCAC CCGTGCCCCC GTCCCCCTCG 
CCCGTGCCCA CCCCCGCCTC GCCCAGCGGC CCGGCCACGC TGGACTTCAC GAGCCAGTTC 
GGGGCCGCCC TGGTGGGGGC GGCCCGGAGG GAGGGGGGCT GGCAGAATGA GGCGCGCCGG 
CGCTCCACGC TGTTCCTGTC CACCGACGCG GGGGACGAGG ACGGCGGGGA CGGCGGGCTG 
GGCACAGGGG CGGCCCCGGG CCCGCGGCTG CGCCACTCCA AATCCATCGA CGAGGGCATG 
TTCTCCGCCG AGCCCTACCT CCGACTGGAG TCTGCGGGCA GCGGCGCGGG CTACGGCGGC 
TACGGGGCCG GTAGCCGAGC CTACGGGGGT GGCGGGGGCA GCAGCGCCTT CACCAGCTTC 
CTGCCCCCGC GACCCCTGGT GCACCCGCTG ACCGGCAAGG CCCTGGATCC CGCCTCCCCG 
CTGGGGCTGG CCCTGGCCGC CCGCGAGCGA GCGCTGAAGG AGTCCTCGGA GGGCGGCGGG 
GCCCCCCAGC CGCCTCCCAG GCCCCCATCG CCCCGCTACG AGGCCCCGCC GCCCACCCCG 
CACCACCACT CGCCCCACGC CCACCACGAG CCAGTGCTGC GTCTCTGGGG GGCCTCCCCG 
CCGGACCCTG CGCGCCGGGA GCTGGGGTAC AGGGCCGGGC TGGGCAGCCA GGAGAAGTCC 
CTTCCCGCCA GCCCGCCCGC CGCCCGGCGT TCCCTGCTAC ACCGCCTGCC GCCCACCGCT 
CCCGGGGTGG GGCCCCTCCT GCTGCAGCTG GGGACGGAGC CCCCGGCCCC GCACCCCGGA 
GTAAGCAAGC CCTGGAGGTC CGCAGCCCCC GAAGAACCCG AGCGGCTGCC GCTGCACGTG 
CGGTTCCTTG AAAACTGCCA GCCCCGGGCC CCTGTGACGA GCGGAAGGGG TCCCCCCTCG 
GAGGACGGGC CGGGGGTCCC GCCGCCCAGC CCACGCCGGT CCGTGCCCCC CTCCCCGACC 
TCCCCGAGGG CCAGCGAAGA GAACGGGCTG CCCCTGCTGG TCCTGCCGCC TCCCGCCCCC 
TCGGTGGATG TGGAAGATGG CGAATTCCTT TTCGTGGAAC CGCTGCCTCC GCCTCTGGAA 
TTCTCCAACA GCTTCGAAAA GCCAGAGTCG CCCCTCACGC CTGGGCCTCC CCACCCGCTG 
CCCGACACAC CTGCCCCTGC CACCCCGTTA CCCCCTGTGC CACCCCCGGC TGTGGCCGCA 
GCCCCTCCCA CCCTGGACTC CACCGCATCC AGCCTGACAT CCTATGACAG CGAGGTGGCC 
ACCCTGACCC AGGGGGCCTC CGCCGCTCCT GGGGACCCCC ATCCACCAGG CCCGCCTGCC 
CCAGCAGCAC CGGCTCCCGC TGCCCCACAG CCTGGCCCGG ACCCTCCGCC TGGCACGGAT 
TCTGGCATCG AGGAGGTGGA CAGTCGGAGC AGCAGTGACC ACCCACTGGA GACCATCAGC 
AGCGCCTCCA CGCTGAGCAG CCTATCTGCC GAAGGTGGTG GCAGCGCAGG GGGTGGGGGC 
GGGGCTGGGG CCGGTGTGGC CAGTGGGCCG GAGCTTCTGG ACACCTATGT GGCCTACCTG 
GACGGCCAGG CCTTTGGGGG CAGCAGTACT CCCGGCCCGC CATACCCTCC TCAGCTCATG 
ACTCCCTCTA AGCTCCGGGG CCGGGCGCTA GGAGCCAGCG GAGGCCTGCG GCCTGGCCCC 
AGCGGGGGAC TCCGAGACCC TGTTACCCCC ACCAGCCCCA CCGTCTCGGT GACAGGGGCT 
GGAACCGATG GGCTGCTGGC CCTGCGTGCT TGTTCAGGAC CCCCCACGGC AGGCGTGGCG 
GGGGGTCCGG TGGCTGTAGA GCCAGAAGTC CCACCGGTGC CCTTGCCGAC GGCCTCCTCT 
CTGCCCCGGA AGCTGCTGCC CTGGGAGGAG GGCCCGGGCC CACCGCCACC ACCTCTGCCC 
GGGCCCTTGG CCCAGCCTCA GGCCTCAGCC TTGGCCACAG TAAAAGCCAG CATCATCAGT 
GAACTCAGCT CCAAGCTTCA GCAGTTTGGG GGCTCCTCGG CAGCTGGCGG CGCTCTGCCC 
TGGGCCCGAG GAGGCAGTGG GGGAGGCGGA GACAGCCACC ACGGGGGAGC CAGCTATGTC 
CCCGAGAGGA CCTCCTCCCT GCAGCGGCAG AGACTCTCCG ACGACTCCCA GTCCTCACTC 
CTCTCCAAGC CTGTCAGCAG CCTGTTTCAG AACTGGCCCA AACCACCTCT GCCGCCACTC 
CCCACCGGAA CAGGGGTCTC CCCTACAGCC GCTGCGGCCC CAGGGGCCAC CTCACCCTCA 
GCCTCCTCCT CCTCCACGTC CACCCGCCAC CTCCAGGGCG TGGAGTTCGA GATGCGGCCC 
CCTCTGCTCC GCCGGGCCCC CAGCCCCTCG CTGCTGCCCG CCTCGGAGCA CAAGGTCAGC 
CCTGCGCCCA GGCCCTCGTC CCTGCCCATC CTGCCTTCCG GACCCCTCTA CCCAGGCCTC 
TTTGACATCC GTGGCTCCCC AACTGGAGGG GCAGGAGGCT CGGCTGACCC CTTCGCCCCA 
GTCTTTGTGC CGCCACACCC GGGGATATCC GGGGGGCTCG GGGGAGCCTT GTCAGGGGCC 
TCGCGCTCCC TCTCACCGAC CCGCCTGCTC TCGCTGCCCC CGGACAAGCC GTTTGGCGCT 
AAACCTCTGG GGTTCTGGAC CAAGTTCGAC GTGGCTGATT GGCTGGAGTG GCTGGGTTTG 
GCGGAGCACC GAGCCCAGTT CCTGGACCAC GAGATCGATG GCTCCCACCT GCCCGCCTTG 
ACCAAGGAGG ACTACGTCGA TCTAGGTGTG ACCAGGGTGG GCCACCGCAT GAACATCGAC 
CGGGCTCTCA AATTCTTCCT GGAGAGGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SHANK1 ( XM_011527014.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_011525316.1 Homo sapiens SH3 and multiple ankyrin repeat domains 1 (SHANK1), transcript variant X2, mRNA.

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CloneID	OHu52293
Clone ID Related Accession (Same CDS sequence)	XM_011527014.2
Accession Version	XM_011527014.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 6459bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	SH3 and multiple ankyrin repeat domains protein 1 isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000019.10) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011527014.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGACCCACA GCCCCGCGAC AAGCGAGGAC GAGGAACGCC ACAGTGCCAG CGAGTGTCCC 
GAGGGGGGCT CAGAGTCCGA CAGCTCCCCA GACGGGCCAG GTCGAGGCCC CCGGGGGACC 
CGGGGCCAGG GCAGTGGGGC ACCTGGTAGC CTGGCCTCTG TTAGAGGCCT CCAGGGCCGC 
TCAATGTCCG TCCCAGACGA CGCCCACTTC AGCATGATGG TCTTCAGGAT TGGCATCCCG 
GACCTGCACC AGACAAAATG CCTTCGCTTC AACCCCGATG CCACCATCTG GACGGCCAAG 
CAGCAGGTGC TCTGTGCCCT GAGCGAGAGC CTGCAGGATG TGCTCAACTA TGGCCTGTTC 
CAACCGGCCA CCTCCGGCCG CGATGCCAAC TTCCTGGAGG AGGAGAGGCT GCTGCGGGAG 
TACCCCCAGT CCTTTGAGAA GGGGGTCCCC TACCTGGAGT TCCGATACAA GACCCGAGTT 
TACAAACAGA CCAACCTGGA TGAGAAGCAG CTGGCCAAGT TGCACACGAA GACGGGGTTG 
AAGAAGTTCC TGGAGTATGT GCAGCTCGGG ACATCTGACA AGGTGGCGCG GCTGCTGGAC 
AAGGGGCTGG ACCCCAATTA CCATGACTCG GATTCGGGAG AGACCCCCTT GACACTGGCG 
GCCCAGACCG AAGGCTCTGT AGAGGTGATT CGAACCCTGT GCCTGGGCGG GGCCCACATT 
GACTTCCGGG CCCGGGATGG CATGACCGCA CTGCATAAGG CCGCATGCGC CCGACACTGC 
CTGGCACTCA CGGCGCTCCT GGACCTTGGG GGTTCCCCCA ACTACAAGGA CCGTCGGGGG 
CTGACCCCTC TGTTCCACAC GGCCATGGTG GGTGGTGACC CCCGATGCTG CGAGCTGCTC 
CTGTTCAACA GGGCCCAGCT GGGCATAGCT GATGAGAACG GCTGGCAGGA AATCCACCAG 
GCCTGCCAGC GGGGTCACTC TCAGCACCTG GAGCATCTGC TTTTCTACGG GGCTGAGCCT 
GGAGCCCAGA ACGCCTCGGG GAACACGGCT CTGCACATCT GCGCCCTCTA CAACAAGGAG 
ACCTGTGCCA GGATCCTCCT GTATCGAGGT GCCGACAAGG ATGTGAAGAA CAACAACGGA 
CAGACCCCCT TCCAGGTGGC AGTGATTGCT GGGAATTTTG AGCTGGGGGA GCTGATCCGA 
AACCACCGAG AACAGGATGT GGTGCCCTTC CAGGAGTCCC CCAAGTACGC GGCCCGGCGA 
CGGGGGCCCC CAGGCACAGG GCTGACGGTG CCCCCGGCGC TGCTGCGGGC CAACAGTGAC 
ACCAGCATGG CGCTGCCCGA CTGGATGGTG TTCTCCGCCC CGGGGGCCGC GTCCTCTGGG 
GCCCCTGGCC CTACCTCAGG GTCCCAGGGC CAGTCGCAGC CCTCGGCCCC CACCACCAAG 
CTCAGCAGCG GGACCCTCCG AAGTGCCAGC AGCCCCCGGG GTGCCAGGGC CCGCTCTCCA 
TCCCGAGGGA GGCACCCTGA GGACGCCAAG AGGCAGCCCC GAGGCCGGCC CAGCTCCAGC 
GGGACACCCC GGGAAGGGCC AGCCGGGGGC ACGGGGGGCT CAGGGGGCCC CGGGGGCTCC 
CTGGGCAGCC GCGGGAGGCG GAGGAAGCTC TACTCAGCGG TACCCGGACG CTCCTTCATG 
GCTGTGAAGT CCTACCAGGC CCAAGCCGAG GGGGAGATCT CCCTGAGCAA GGGCGAGAAG 
ATCAAAGTAC TTAGCATCGG GGAAGGAGGC TTCTGGGAAG GCCAGGTCAA AGGTCGTGTT 
GGCTGGTTCC CCTCTGACTG CCTGGAAGAA GTGGCGAATC GCTCTCAGGA GAGCAAGCAA 
GAAAGCCGCA GTGACAAGGC AAAGAGACTC TTCCGGCATT ATACCGTGGG CTCCTACGAC 
AGCTTTGATG CCCCAAGCGA TTACATCATT AAGGAGAAGA CAGTCTTGCT GCAGAAGAAG 
GACAGTGAGG GGTTTGGGTT CGTGCTCCGG GGGGCCAAGG CGCAGACCCC CATCGAGGAG 
TTCACCCCCA CCCCGGCCTT CCCGGCGCTG CAGTACCTGG AGTCGGTGGA CGAGGGTGGC 
GTGGCATGGC GAGCTGGACT GCGAATGGGA GACTTCCTCA TCGAGGTGAA CGGGCAGAAT 
GTGGTGAAGG TCGGCCACCG ACAGGTGGTG AACATGATCC GCCAAGGGGG CAACACGCTG 
ATGGTGAAGG TGGTGATGGT CACCAGGCAC CCGGACATGG ATGAGGCAGT GCACAAGAAA 
GCACCCCAGC AGGCCAAGCG GCTGCCGCCC CCAACCATCT CCCTGCGTTC CAAATCTATG 
ACCTCAGAGC TGGAGGAGAT GGAGTACGAG CAGCAGCCGG CGCCGGTGCC CAGCATGGAG 
AAAAAGCGGA CCGTGTATCA GATGGCTCTC AACAAACTGG ACGAAATCCT GGCCGCAGCT 
CAACAGACCA TCAGTGCAAG CGAAAGCCCT GGTCCCGGTG GCCTCGCGTC CCTGGGCAAA 
CACCGACCCA AAGGTTTCTT TGCCACTGAG TCGAGCTTCG ATCCCCACCA CCGTGCCCAG 
CCAAGTTACG AGCGTCCTTC TTTCCTGCCT CCAGGACCTG GGTTGATGCT CCGGCAAAAA 
TCTATCGGTG CGGCAGAAGA TGACAGACCT TACCTAGCAC CCCCAGCCAT GAAATTCAGC 
CGCAGCCTGT CTGTGCCTGG TTCGGAGGAC ATTCCCCCGC CACCCACCAC GTCCCCACCG 
GAGCCTCCCT ACAGCACACC TCCAGTCCCC TCCTCCTCAG GGCGCCTCAC CCCCTCCCCT 
CGGGGAGGGC CCTTCAACCC TGGCTCTGGT GGCCCCCTCC CCGCCTCCTC CCCTGCATCC 
TTTGACGGGC CCTCCCCTCC CGACACTCGC GTGGGGAGCC GCGAGAAGAG CCTGTACCAC 
AGTGGGCCCC TGCCCCCGGC CCACCACCAC CCGCCCCACC ACCACCACCA CCACGCCCCG 
CCCCCTCAGC CCCACCACCA CCACGCCCAC CCCCCTCATC CTCCCGAGAT GGAGACAGGC 
GGCTCTCCCG ACGACCCTCC ACCCCGCCTG GCTCTGGGGC CCCAGCCCAG CCTGCGAGGC 
TGGAGGGGCG GCGGGCCCAG CCCGACCCCG GGGGCCCCGT CCCCATCGCA CCACGGCAGC 
GCGGGCGGGG GCGGCGGCTC CTCCCAGGGC CCGGCTCTAC GCTATTTCCA GCTGCCCCCG 
CGGGCGGCCA GCGCAGCCAT GTACGTGCCC GCCCGCTCGG GCCGCGGCCG CAAGGGCCCG 
CTGGTCAAGC AGACCAAGGT GGAAGGCGAG CCCCAGAAGG GCGGCGGCCT CCCGCCCGCG 
CCGTCGCCCA CGTCCCCGGC CTCCCCGCAG CCGCCGCCCG CCGTGGCCGC GCCCTCGGAG 
AAGAACTCCA TCCCCATCCC CACCATCATC ATCAAGGCCC CGTCCACCAG TAGCAGCGGC 
CGCAGCAGCC AGGGCAGCAG CACCGAGGCG GAGCCCCCCA CCCAGCCGGA GCCCACGGGA 
GGCGGCGGCG GCGGCGGCTC CTCGCCCAGC CCCGCCCCGG CCATGTCACC CGTGCCCCCG 
TCCCCCTCGC CCGTGCCCAC CCCCGCCTCG CCCAGCGGCC CGGCCACGCT GGACTTCACG 
AGCCAGTTCG GGGCCGCCCT GGTGGGGGCG GCCCGGAGGG AGGGGGGCTG GCAGAATGAG 
GCGCGCCGGC GCTCCACGCT GTTCCTGTCC ACCGACGCGG GGGACGAGGA CGGCGGGGAC 
GGCGGGCTGG GCACAGGGGC GGCCCCGGGC CCGCGGCTGC GCCACTCCAA ATCCATCGAC 
GAGGGCATGT TCTCCGCCGA GCCCTACCTC CGACTGGAGT CTGCGGGCAG CGGCGCGGGC 
TACGGCGGCT ACGGGGCCGG TAGCCGAGCC TACGGGGGTG GCGGGGGCAG CAGCGCCTTC 
ACCAGCTTCC TGCCCCCGCG ACCCCTGGTG CACCCGCTGA CCGGCAAGGC CCTGGATCCC 
GCCTCCCCGC TGGGGCTGGC CCTGGCCGCC CGCGAGCGAG CGCTGAAGGA GTCCTCGGAG 
GGCGGCGGGG CCCCCCAGCC GCCTCCCAGG CCCCCATCGC CCCGCTACGA GGCCCCGCCG 
CCCACCCCGC ACCACCACTC GCCCCACGCC CACCACGAGC CAGTGCTGCG TCTCTGGGGG 
GCCTCCCCGC CGGACCCTGC GCGCCGGGAG CTGGGGTACA GGGCCGGGCT GGGCAGCCAG 
GAGAAGTCCC TTCCCGCCAG CCCGCCCGCC GCCCGGCGTT CCCTGCTACA CCGCCTGCCG 
CCCACCGCTC CCGGGGTGGG GCCCCTCCTG CTGCAGCTGG GGACGGAGCC CCCGGCCCCG 
CACCCCGGAG TAAGCAAGCC CTGGAGGTCC GCAGCCCCCG AAGAACCCGA GCGGCTGCCG 
CTGCACGTGC GGTTCCTTGA AAACTGCCAG CCCCGGGCCC CTGTGACGAG CGGAAGGGGT 
CCCCCCTCGG AGGACGGGCC GGGGGTCCCG CCGCCCAGCC CACGCCGGTC CGTGCCCCCC 
TCCCCGACCT CCCCGAGGGC CAGCGAAGAG AACGGGCTGC CCCTGCTGGT CCTGCCGCCT 
CCCGCCCCCT CGGTGGATGT GGAAGATGGC GAATTCCTTT TCGTGGAACC GCTGCCTCCG 
CCTCTGGAAT TCTCCAACAG CTTCGAAAAG CCAGAGTCGC CCCTCACGCC TGGGCCTCCC 
CACCCGCTGC CCGACACACC TGCCCCTGCC ACCCCGTTAC CCCCTGTGCC ACCCCCGGCT 
GTGGCCGCAG CCCCTCCCAC CCTGGACTCC ACCGCATCCA GCCTGACATC CTATGACAGC 
GAGGTGGCCA CCCTGACCCA GGGGGCCTCC GCCGCTCCTG GGGACCCCCA TCCACCAGGC 
CCGCCTGCCC CAGCAGCACC GGCTCCCGCT GCCCCACAGC CTGGCCCGGA CCCTCCGCCT 
GGCACGGATT CTGGCATCGA GGAGGTGGAC AGTCGGAGCA GCAGTGACCA CCCACTGGAG 
ACCATCAGCA GCGCCTCCAC GCTGAGCAGC CTATCTGCCG AAGGTGGTGG CAGCGCAGGG 
GGTGGGGGCG GGGCTGGGGC CGGTGTGGCC AGTGGGCCGG AGCTTCTGGA CACCTATGTG 
GCCTACCTGG ACGGCCAGGC CTTTGGGGGC AGCAGTACTC CCGGCCCGCC ATACCCTCCT 
CAGCTCATGA CTCCCTCTAA GCTCCGGGGC CGGGCGCTAG GAGCCAGCGG AGGCCTGCGG 
CCTGGCCCCA GCGGGGGACT CCGAGACCCT GTTACCCCCA CCAGCCCCAC CGTCTCGGTG 
ACAGGGGCTG GAACCGATGG GCTGCTGGCC CTGCGTGCTT GTTCAGGACC CCCCACGGCA 
GGCGTGGCGG GGGGTCCGGT GGCTGTAGAG CCAGAAGTCC CACCGGTGCC CTTGCCGACG 
GCCTCCTCTC TGCCCCGGAA GCTGCTGCCC TGGGAGGAGG GCCCGGGCCC ACCGCCACCA 
CCTCTGCCCG GGCCCTTGGC CCAGCCTCAG GCCTCAGCCT TGGCCACAGT AAAAGCCAGC 
ATCATCAGTG AACTCAGCTC CAAGCTTCAG CAGTTTGGGG GCTCCTCGGC AGCTGGCGGC 
GCTCTGCCCT GGGCCCGAGG AGGCAGTGGG GGAGGCGGAG ACAGCCACCA CGGGGGAGCC 
AGCTATGTCC CCGAGAGGAC CTCCTCCCTG CAGCGGCAGA GACTCTCCGA CGACTCCCAG 
TCCTCACTCC TCTCCAAGCC TGTCAGCAGC CTGTTTCAGA ACTGGCCCAA ACCACCTCTG 
CCGCCACTCC CCACCGGAAC AGGGGTCTCC CCTACAGCCG CTGCGGCCCC AGGGGCCACC 
TCACCCTCAG CCTCCTCCTC CTCCACGTCC ACCCGCCACC TCCAGGGCGT GGAGTTCGAG 
ATGCGGCCCC CTCTGCTCCG CCGGGCCCCC AGCCCCTCGC TGCTGCCCGC CTCGGAGCAC 
AAGGTCAGCC CTGCGCCCAG GCCCTCGTCC CTGCCCATCC TGCCTTCCGG ACCCCTCTAC 
CCAGGCCTCT TTGACATCCG TGGCTCCCCA ACTGGAGGGG CAGGAGGCTC GGCTGACCCC 
TTCGCCCCAG TCTTTGTGCC GCCACACCCG GGGATATCCG GGGGGCTCGG GGGAGCCTTG 
TCAGGGGCCT CGCGCTCCCT CTCACCGACC CGCCTGCTCT CGCTGCCCCC GGACAAGCCG 
TTTGGCGCTA AACCTCTGGG GTTCTGGACC AAGTTCGACG TGGCTGATTG GCTGGAGTGG 
CTGGGTTTGG CGGAGCACCG AGCCCAGTTC CTGGACCACG AGATCGATGG CTCCCACCTG 
CCCGCCTTGA CCAAGGAGGA CTACGTCGAT CTAGGTGTGA CCAGGGTGGG CCACCGCATG 
AACATCGACC GGGCTCTCAA ATTCTTCCTG GAGAGGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011525316.1
CDS	418..6876
Translation	MTHSPATSEDEERHSASECPEGGSESDSSPDGPGRGPRGTRGQGSGAPGSLASVRGLQGRSMSVPDDAHFSMMVFRIGIPDLHQTKCLRFNPDATIWTAKQQVLCALSESLQDVLNYGLFQPATSGRDANFLEEERLLREYPQSFEKGVPYLEFRYKTRVYKQTNLDEKQLAKLHTKTGLKKFLEYVQLGTSDKVARLLDKGLDPNYHDSDSGETPLTLAAQTEGSVEVIRTLCLGGAHIDFRARDGMTALHKAACARHCLALTALLDLGGSPNYKDRRGLTPLFHTAMVGGDPRCCELLLFNRAQLGIADENGWQEIHQACQRGHSQHLEHLLFYGAEPGAQNASGNTALHICALYNKETCARILLYRGADKDVKNNNGQTPFQVAVIAGNFELGELIRNHREQDVVPFQESPKYAARRRGPPGTGLTVPPALLRANSDTSMALPDWMVFSAPGAASSGAPGPTSGSQGQSQPSAPTTKLSSGTLRSASSPRGARARSPSRGRHPEDAKRQPRGRPSSSGTPREGPAGGTGGSGGPGGSLGSRGRRRKLYSAVPGRSFMAVKSYQAQAEGEISLSKGEKIKVLSIGEGGFWEGQVKGRVGWFPSDCLEEVANRSQESKQESRSDKAKRLFRHYTVGSYDSFDAPSDYIIKEKTVLLQKKDSEGFGFVLRGAKAQTPIEEFTPTPAFPALQYLESVDEGGVAWRAGLRMGDFLIEVNGQNVVKVGHRQVVNMIRQGGNTLMVKVVMVTRHPDMDEAVHKKAPQQAKRLPPPTISLRSKSMTSELEEMEYEQQPAPVPSMEKKRTVYQMALNKLDEILAAAQQTISASESPGPGGLASLGKHRPKGFFATESSFDPHHRAQPSYERPSFLPPGPGLMLRQKSIGAAEDDRPYLAPPAMKFSRSLSVPGSEDIPPPPTTSPPEPPYSTPPVPSSSGRLTPSPRGGPFNPGSGGPLPASSPASFDGPSPPDTRVGSREKSLYHSGPLPPAHHHPPHHHHHHAPPPQPHHHHAHPPHPPEMETGGSPDDPPPRLALGPQPSLRGWRGGGPSPTPGAPSPSHHGSAGGGGGSSQGPALRYFQLPPRAASAAMYVPARSGRGRKGPLVKQTKVEGEPQKGGGLPPAPSPTSPASPQPPPAVAAPSEKNSIPIPTIIIKAPSTSSSGRSSQGSSTEAEPPTQPEPTGGGGGGGSSPSPAPAMSPVPPSPSPVPTPASPSGPATLDFTSQFGAALVGAARREGGWQNEARRRSTLFLSTDAGDEDGGDGGLGTGAAPGPRLRHSKSIDEGMFSAEPYLRLESAGSGAGYGGYGAGSRAYGGGGGSSAFTSFLPPRPLVHPLTGKALDPASPLGLALAARERALKESSEGGGAPQPPPRPPSPRYEAPPPTPHHHSPHAHHEPVLRLWGASPPDPARRELGYRAGLGSQEKSLPASPPAARRSLLHRLPPTAPGVGPLLLQLGTEPPAPHPGVSKPWRSAAPEEPERLPLHVRFLENCQPRAPVTSGRGPPSEDGPGVPPPSPRRSVPPSPTSPRASEENGLPLLVLPPPAPSVDVEDGEFLFVEPLPPPLEFSNSFEKPESPLTPGPPHPLPDTPAPATPLPPVPPPAVAAAPPTLDSTASSLTSYDSEVATLTQGASAAPGDPHPPGPPAPAAPAPAAPQPGPDPPPGTDSGIEEVDSRSSSDHPLETISSASTLSSLSAEGGGSAGGGGGAGAGVASGPELLDTYVAYLDGQAFGGSSTPGPPYPPQLMTPSKLRGRALGASGGLRPGPSGGLRDPVTPTSPTVSVTGAGTDGLLALRACSGPPTAGVAGGPVAVEPEVPPVPLPTASSLPRKLLPWEEGPGPPPPPLPGPLAQPQASALATVKASIISELSSKLQQFGGSSAAGGALPWARGGSGGGGDSHHGGASYVPERTSSLQRQRLSDDSQSSLLSKPVSSLFQNWPKPPLPPLPTGTGVSPTAAAAPGATSPSASSSSTSTRHLQGVEFEMRPPLLRRAPSPSLLPASEHKVSPAPRPSSLPILPSGPLYPGLFDIRGSPTGGAGGSADPFAPVFVPPHPGISGGLGGALSGASRSLSPTRLLSLPPDKPFGAKPLGFWTKFDVADWLEWLGLAEHRAQFLDHEIDGSHLPALTKEDYVDLGVTRVGHRMNIDRALKFFLER

Target ORF information:

RefSeq Version	XM_011527014.2
Organism	Homo sapiens(human)
Definition	Homo sapiens SH3 and multiple ankyrin repeat domains 1 (SHANK1), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011527014.2

ORF Insert Sequence:

ATGACCCACA GCCCCGCGAC AAGCGAGGAC GAGGAACGCC ACAGTGCCAG CGAGTGTCCC 
GAGGGGGGCT CAGAGTCCGA CAGCTCCCCA GACGGGCCAG GTCGAGGCCC CCGGGGGACC 
CGGGGCCAGG GCAGTGGGGC ACCTGGTAGC CTGGCCTCTG TTAGAGGCCT CCAGGGCCGC 
TCAATGTCCG TCCCAGACGA CGCCCACTTC AGCATGATGG TCTTCAGGAT TGGCATCCCG 
GACCTGCACC AGACAAAATG CCTTCGCTTC AACCCCGATG CCACCATCTG GACGGCCAAG 
CAGCAGGTGC TCTGTGCCCT GAGCGAGAGC CTGCAGGATG TGCTCAACTA TGGCCTGTTC 
CAACCGGCCA CCTCCGGCCG CGATGCCAAC TTCCTGGAGG AGGAGAGGCT GCTGCGGGAG 
TACCCCCAGT CCTTTGAGAA GGGGGTCCCC TACCTGGAGT TCCGATACAA GACCCGAGTT 
TACAAACAGA CCAACCTGGA TGAGAAGCAG CTGGCCAAGT TGCACACGAA GACGGGGTTG 
AAGAAGTTCC TGGAGTATGT GCAGCTCGGG ACATCTGACA AGGTGGCGCG GCTGCTGGAC 
AAGGGGCTGG ACCCCAATTA CCATGACTCG GATTCGGGAG AGACCCCCTT GACACTGGCG 
GCCCAGACCG AAGGCTCTGT AGAGGTGATT CGAACCCTGT GCCTGGGCGG GGCCCACATT 
GACTTCCGGG CCCGGGATGG CATGACCGCA CTGCATAAGG CCGCATGCGC CCGACACTGC 
CTGGCACTCA CGGCGCTCCT GGACCTTGGG GGTTCCCCCA ACTACAAGGA CCGTCGGGGG 
CTGACCCCTC TGTTCCACAC GGCCATGGTG GGTGGTGACC CCCGATGCTG CGAGCTGCTC 
CTGTTCAACA GGGCCCAGCT GGGCATAGCT GATGAGAACG GCTGGCAGGA AATCCACCAG 
GCCTGCCAGC GGGGTCACTC TCAGCACCTG GAGCATCTGC TTTTCTACGG GGCTGAGCCT 
GGAGCCCAGA ACGCCTCGGG GAACACGGCT CTGCACATCT GCGCCCTCTA CAACAAGGAG 
ACCTGTGCCA GGATCCTCCT GTATCGAGGT GCCGACAAGG ATGTGAAGAA CAACAACGGA 
CAGACCCCCT TCCAGGTGGC AGTGATTGCT GGGAATTTTG AGCTGGGGGA GCTGATCCGA 
AACCACCGAG AACAGGATGT GGTGCCCTTC CAGGAGTCCC CCAAGTACGC GGCCCGGCGA 
CGGGGGCCCC CAGGCACAGG GCTGACGGTG CCCCCGGCGC TGCTGCGGGC CAACAGTGAC 
ACCAGCATGG CGCTGCCCGA CTGGATGGTG TTCTCCGCCC CGGGGGCCGC GTCCTCTGGG 
GCCCCTGGCC CTACCTCAGG GTCCCAGGGC CAGTCGCAGC CCTCGGCCCC CACCACCAAG 
CTCAGCAGCG GGACCCTCCG AAGTGCCAGC AGCCCCCGGG GTGCCAGGGC CCGCTCTCCA 
TCCCGAGGGA GGCACCCTGA GGACGCCAAG AGGCAGCCCC GAGGCCGGCC CAGCTCCAGC 
GGGACACCCC GGGAAGGGCC AGCCGGGGGC ACGGGGGGCT CAGGGGGCCC CGGGGGCTCC 
CTGGGCAGCC GCGGGAGGCG GAGGAAGCTC TACTCAGCGG TACCCGGACG CTCCTTCATG 
GCTGTGAAGT CCTACCAGGC CCAAGCCGAG GGGGAGATCT CCCTGAGCAA GGGCGAGAAG 
ATCAAAGTAC TTAGCATCGG GGAAGGAGGC TTCTGGGAAG GCCAGGTCAA AGGTCGTGTT 
GGCTGGTTCC CCTCTGACTG CCTGGAAGAA GTGGCGAATC GCTCTCAGGA GAGCAAGCAA 
GAAAGCCGCA GTGACAAGGC AAAGAGACTC TTCCGGCATT ATACCGTGGG CTCCTACGAC 
AGCTTTGATG CCCCAAGCGA TTACATCATT AAGGAGAAGA CAGTCTTGCT GCAGAAGAAG 
GACAGTGAGG GGTTTGGGTT CGTGCTCCGG GGGGCCAAGG CGCAGACCCC CATCGAGGAG 
TTCACCCCCA CCCCGGCCTT CCCGGCGCTG CAGTACCTGG AGTCGGTGGA CGAGGGTGGC 
GTGGCATGGC GAGCTGGACT GCGAATGGGA GACTTCCTCA TCGAGGTGAA CGGGCAGAAT 
GTGGTGAAGG TCGGCCACCG ACAGGTGGTG AACATGATCC GCCAAGGGGG CAACACGCTG 
ATGGTGAAGG TGGTGATGGT CACCAGGCAC CCGGACATGG ATGAGGCAGT GCACAAGAAA 
GCACCCCAGC AGGCCAAGCG GCTGCCGCCC CCAACCATCT CCCTGCGTTC CAAATCTATG 
ACCTCAGAGC TGGAGGAGAT GGAGTACGAG CAGCAGCCGG CGCCGGTGCC CAGCATGGAG 
AAAAAGCGGA CCGTGTATCA GATGGCTCTC AACAAACTGG ACGAAATCCT GGCCGCAGCT 
CAACAGACCA TCAGTGCAAG CGAAAGCCCT GGTCCCGGTG GCCTCGCGTC CCTGGGCAAA 
CACCGACCCA AAGGTTTCTT TGCCACTGAG TCGAGCTTCG ATCCCCACCA CCGTGCCCAG 
CCAAGTTACG AGCGTCCTTC TTTCCTGCCT CCAGGACCTG GGTTGATGCT CCGGCAAAAA 
TCTATCGGTG CGGCAGAAGA TGACAGACCT TACCTAGCAC CCCCAGCCAT GAAATTCAGC 
CGCAGCCTGT CTGTGCCTGG TTCGGAGGAC ATTCCCCCGC CACCCACCAC GTCCCCACCG 
GAGCCTCCCT ACAGCACACC TCCAGTCCCC TCCTCCTCAG GGCGCCTCAC CCCCTCCCCT 
CGGGGAGGGC CCTTCAACCC TGGCTCTGGT GGCCCCCTCC CCGCCTCCTC CCCTGCATCC 
TTTGACGGGC CCTCCCCTCC CGACACTCGC GTGGGGAGCC GCGAGAAGAG CCTGTACCAC 
AGTGGGCCCC TGCCCCCGGC CCACCACCAC CCGCCCCACC ACCACCACCA CCACGCCCCG 
CCCCCTCAGC CCCACCACCA CCACGCCCAC CCCCCTCATC CTCCCGAGAT GGAGACAGGC 
GGCTCTCCCG ACGACCCTCC ACCCCGCCTG GCTCTGGGGC CCCAGCCCAG CCTGCGAGGC 
TGGAGGGGCG GCGGGCCCAG CCCGACCCCG GGGGCCCCGT CCCCATCGCA CCACGGCAGC 
GCGGGCGGGG GCGGCGGCTC CTCCCAGGGC CCGGCTCTAC GCTATTTCCA GCTGCCCCCG 
CGGGCGGCCA GCGCAGCCAT GTACGTGCCC GCCCGCTCGG GCCGCGGCCG CAAGGGCCCG 
CTGGTCAAGC AGACCAAGGT GGAAGGCGAG CCCCAGAAGG GCGGCGGCCT CCCGCCCGCG 
CCGTCGCCCA CGTCCCCGGC CTCCCCGCAG CCGCCGCCCG CCGTGGCCGC GCCCTCGGAG 
AAGAACTCCA TCCCCATCCC CACCATCATC ATCAAGGCCC CGTCCACCAG TAGCAGCGGC 
CGCAGCAGCC AGGGCAGCAG CACCGAGGCG GAGCCCCCCA CCCAGCCGGA GCCCACGGGA 
GGCGGCGGCG GCGGCGGCTC CTCGCCCAGC CCCGCCCCGG CCATGTCACC CGTGCCCCCG 
TCCCCCTCGC CCGTGCCCAC CCCCGCCTCG CCCAGCGGCC CGGCCACGCT GGACTTCACG 
AGCCAGTTCG GGGCCGCCCT GGTGGGGGCG GCCCGGAGGG AGGGGGGCTG GCAGAATGAG 
GCGCGCCGGC GCTCCACGCT GTTCCTGTCC ACCGACGCGG GGGACGAGGA CGGCGGGGAC 
GGCGGGCTGG GCACAGGGGC GGCCCCGGGC CCGCGGCTGC GCCACTCCAA ATCCATCGAC 
GAGGGCATGT TCTCCGCCGA GCCCTACCTC CGACTGGAGT CTGCGGGCAG CGGCGCGGGC 
TACGGCGGCT ACGGGGCCGG TAGCCGAGCC TACGGGGGTG GCGGGGGCAG CAGCGCCTTC 
ACCAGCTTCC TGCCCCCGCG ACCCCTGGTG CACCCGCTGA CCGGCAAGGC CCTGGATCCC 
GCCTCCCCGC TGGGGCTGGC CCTGGCCGCC CGCGAGCGAG CGCTGAAGGA GTCCTCGGAG 
GGCGGCGGGG CCCCCCAGCC GCCTCCCAGG CCCCCATCGC CCCGCTACGA GGCCCCGCCG 
CCCACCCCGC ACCACCACTC GCCCCACGCC CACCACGAGC CAGTGCTGCG TCTCTGGGGG 
GCCTCCCCGC CGGACCCTGC GCGCCGGGAG CTGGGGTACA GGGCCGGGCT GGGCAGCCAG 
GAGAAGTCCC TTCCCGCCAG CCCGCCCGCC GCCCGGCGTT CCCTGCTACA CCGCCTGCCG 
CCCACCGCTC CCGGGGTGGG GCCCCTCCTG CTGCAGCTGG GGACGGAGCC CCCGGCCCCG 
CACCCCGGAG TAAGCAAGCC CTGGAGGTCC GCAGCCCCCG AAGAACCCGA GCGGCTGCCG 
CTGCACGTGC GGTTCCTTGA AAACTGCCAG CCCCGGGCCC CTGTGACGAG CGGAAGGGGT 
CCCCCCTCGG AGGACGGGCC GGGGGTCCCG CCGCCCAGCC CACGCCGGTC CGTGCCCCCC 
TCCCCGACCT CCCCGAGGGC CAGCGAAGAG AACGGGCTGC CCCTGCTGGT CCTGCCGCCT 
CCCGCCCCCT CGGTGGATGT GGAAGATGGC GAATTCCTTT TCGTGGAACC GCTGCCTCCG 
CCTCTGGAAT TCTCCAACAG CTTCGAAAAG CCAGAGTCGC CCCTCACGCC TGGGCCTCCC 
CACCCGCTGC CCGACACACC TGCCCCTGCC ACCCCGTTAC CCCCTGTGCC ACCCCCGGCT 
GTGGCCGCAG CCCCTCCCAC CCTGGACTCC ACCGCATCCA GCCTGACATC CTATGACAGC 
GAGGTGGCCA CCCTGACCCA GGGGGCCTCC GCCGCTCCTG GGGACCCCCA TCCACCAGGC 
CCGCCTGCCC CAGCAGCACC GGCTCCCGCT GCCCCACAGC CTGGCCCGGA CCCTCCGCCT 
GGCACGGATT CTGGCATCGA GGAGGTGGAC AGTCGGAGCA GCAGTGACCA CCCACTGGAG 
ACCATCAGCA GCGCCTCCAC GCTGAGCAGC CTATCTGCCG AAGGTGGTGG CAGCGCAGGG 
GGTGGGGGCG GGGCTGGGGC CGGTGTGGCC AGTGGGCCGG AGCTTCTGGA CACCTATGTG 
GCCTACCTGG ACGGCCAGGC CTTTGGGGGC AGCAGTACTC CCGGCCCGCC ATACCCTCCT 
CAGCTCATGA CTCCCTCTAA GCTCCGGGGC CGGGCGCTAG GAGCCAGCGG AGGCCTGCGG 
CCTGGCCCCA GCGGGGGACT CCGAGACCCT GTTACCCCCA CCAGCCCCAC CGTCTCGGTG 
ACAGGGGCTG GAACCGATGG GCTGCTGGCC CTGCGTGCTT GTTCAGGACC CCCCACGGCA 
GGCGTGGCGG GGGGTCCGGT GGCTGTAGAG CCAGAAGTCC CACCGGTGCC CTTGCCGACG 
GCCTCCTCTC TGCCCCGGAA GCTGCTGCCC TGGGAGGAGG GCCCGGGCCC ACCGCCACCA 
CCTCTGCCCG GGCCCTTGGC CCAGCCTCAG GCCTCAGCCT TGGCCACAGT AAAAGCCAGC 
ATCATCAGTG AACTCAGCTC CAAGCTTCAG CAGTTTGGGG GCTCCTCGGC AGCTGGCGGC 
GCTCTGCCCT GGGCCCGAGG AGGCAGTGGG GGAGGCGGAG ACAGCCACCA CGGGGGAGCC 
AGCTATGTCC CCGAGAGGAC CTCCTCCCTG CAGCGGCAGA GACTCTCCGA CGACTCCCAG 
TCCTCACTCC TCTCCAAGCC TGTCAGCAGC CTGTTTCAGA ACTGGCCCAA ACCACCTCTG 
CCGCCACTCC CCACCGGAAC AGGGGTCTCC CCTACAGCCG CTGCGGCCCC AGGGGCCACC 
TCACCCTCAG CCTCCTCCTC CTCCACGTCC ACCCGCCACC TCCAGGGCGT GGAGTTCGAG 
ATGCGGCCCC CTCTGCTCCG CCGGGCCCCC AGCCCCTCGC TGCTGCCCGC CTCGGAGCAC 
AAGGTCAGCC CTGCGCCCAG GCCCTCGTCC CTGCCCATCC TGCCTTCCGG ACCCCTCTAC 
CCAGGCCTCT TTGACATCCG TGGCTCCCCA ACTGGAGGGG CAGGAGGCTC GGCTGACCCC 
TTCGCCCCAG TCTTTGTGCC GCCACACCCG GGGATATCCG GGGGGCTCGG GGGAGCCTTG 
TCAGGGGCCT CGCGCTCCCT CTCACCGACC CGCCTGCTCT CGCTGCCCCC GGACAAGCCG 
TTTGGCGCTA AACCTCTGGG GTTCTGGACC AAGTTCGACG TGGCTGATTG GCTGGAGTGG 
CTGGGTTTGG CGGAGCACCG AGCCCAGTTC CTGGACCACG AGATCGATGG CTCCCACCTG 
CCCGCCTTGA CCAAGGAGGA CTACGTCGAT CTAGGTGTGA CCAGGGTGGG CCACCGCATG 
AACATCGACC GGGCTCTCAA ATTCTTCCTG GAGAGGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Behavioral phenotypes and neurobiological mechanisms in the Shank1 mouse model for autism spectrum disorder: A translational perspective.
Behavioural brain research(2017 Sep)
Sungur A?,Schwarting RKW,W?hr M

SHANK proteins limit integrin activation by directly interacting with Rap1 and?R-Ras.
Nature cell biology19(4)292-305(2017 Apr)
Lilja J,Zacharchenko T,Georgiadou M,Jacquemet G,De Franceschi N,Peuhu E,Hamidi H,Pouwels J,Martens V,Nia FH,Beifuss M,Boeckers T,Kreienkamp HJ,Barsukov IL,Ivaska J

Meta-analysis of SHANK Mutations in Autism Spectrum Disorders: a gradient of severity in cognitive impairments.
PLoS genetics10(9)e1004580(2014 Sep)
Leblond CS,Nava C,Polge A,Gauthier J,Huguet G,Lumbroso S,Giuliano F,Stordeur C,Depienne C,Mouzat K,Pinto D,Howe J,Lemi?re N,Durand CM,Guibert J,Ey E,Toro R,Peyre H,Mathieu A,Amsellem F,Rastam M,Gillberg IC,Rappold GA,Holt R,Monaco AP,Maestrini E,Galan P,Heron D,Jacquette A,Afenjar A,Rastetter A,Brice A,Devillard F,Assouline B,Laffargue F,Lespinasse J,Chiesa J,Rivier F,Bonneau D,Regnault B,Zelenika D,Delepine M,Lathrop M,Sanlaville D,Schluth-Bolard C,Edery P,Perrin L,Tabet AC,Schmeisser MJ,Boeckers TM,Coleman M,Sato D,Szatmari P,Scherer SW,Rouleau GA,Betancur C,Leboyer M,Gillberg C,Delorme R,Bourgeron T

FMRP interacts with G-quadruplex structures in the 3'-UTR of its dendritic target Shank1 mRNA.
RNA biology11(11)1364-74(2014)
Zhang Y,Gaetano CM,Williams KR,Bassell GJ,Mihailescu MR

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SHANK1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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