HEBP1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	HEBP1
Entrez Gene ID	50865
Full Name	heme binding protein 1
Synonyms	HBP,HEBP
General protein information	Preferred Names heme binding protein 1 Names heme-binding protein 1 p22HBP
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 12 Map Location: 12p13.1
Summary	The full-length protein encoded by this gene is an intracellular tetrapyrrole-binding protein. This protein includes a natural chemoattractant peptide of 21 amino acids at the N-terminus, which is a natural ligand for formyl peptide receptor-like receptor 2 (FPRL2) and promotes calcium mobilization and chemotaxis in monocytes and dendritic cells. [provided by RefSeq, Jul 2008].
Disorder MIM:	605826

mRNA and Protein(s)

mRNA	Protein	Name
NM_015987.4	NP_057071.2	heme-binding protein 1
NM_015987.5	NP_057071.2	heme-binding protein 1

Pathways from BioSystems

Homologies

Gallus gallus (chicken)	HEBP1	NP_001025925.1
Homo sapiens (human)	HEBP1	NP_057071.2
	HEBP1	XP_001086941.1
Canis lupus familiaris (dog)	HEBP1	XP_534884.1
Pan troglodytes (chimpanzee)	HEBP1	XP_528742.2
Mus musculus (house mouse)	Hebp1	NP_038574.2
Bos taurus (cattle)	HEBP1	NP_001069453.1
Rattus norvegicus (Norway rat)	Hebp1	NP_001102121.1
Xenopus tropicalis (tropical clawed frog)	hebp1	NP_001004901.1

Gene Ontology
Bibliography

Related articles in PubMed

Processing of HEBP1 by cathepsin D gives rise to F2L, the agonist of formyl peptide receptor 3.
Devosse T, Dutoit R, Migeotte I, De Nadai P, Imbault V, Communi D, Salmon I, Parmentier M
Journal of immunology (Baltimore, Md. : 1950)187(3)1475-85(2011 Aug)

Tetrapyrrole binding affinity of the murine and human p22HBP heme-binding proteins.
Micaelo NM, Macedo AL, Goodfellow BJ, F?lix V
Journal of molecular graphics & modelling29(3)396-405(2010 Nov)

Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S,
Diabetes care33(10)2250-3(2010 Oct)

Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, , ,
American journal of human genetics85(5)628-42(2009 Nov)

Large-scale proteomics and phosphoproteomics of urinary exosomes.
Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA
Journal of the American Society of Nephrology : JASN20(2)363-79(2009 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The functional activity of purified full-length HEBP1 has been evaluated on human formyl peptide receptor (FPR)3-expressing CHO-K1 cells
Title: Processing of HEBP1 by cathepsin D gives rise to F2L, the agonist of formyl peptide receptor 3.

Results present a systematic molecular modeling study of the binding properties of murine and human p22HBP protein (heme-binding protein) with four tetrapyrrole ring systems belonging to the heme biosynthetic pathway.
Title: Tetrapyrrole binding affinity of the murine and human p22HBP heme-binding proteins.

Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.

Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.

Observational study of gene-disease association. (HuGE Navigator)
Title: Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.

The following HEBP1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the HEBP1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu11165	NM_015987.5 Latest version!	Homo sapiens heme binding protein 1 (HEBP1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
View Old Accession Versions >>
OHu11165	NM_015987.4	Homo sapiens heme binding protein 1 (HEBP1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

HEBP1 ( NM_015987.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_057071.2 Homo sapiens heme binding protein 1 (HEBP1), mRNA.

Price & Availability↑

CloneID	OHu11165
Clone ID Related Accession (Same CDS sequence)	NM_015987.4 , NM_015987.5
Accession Version	NM_015987.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 570bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-27
Organism	Homo sapiens(human)
Product	heme-binding protein 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CF126276.1, AC007688.15 and AW452041.1. On Jul 17, 2010 this sequence version replaced NM_015987.3. ##Evidence-Data-START## Transcript exon combination :: ERR279859.4914.1, ERR279849.5348.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTTGGGCA TGATCAAGAA CTCGCTGTTC GGAAGCGTAG AGACGTGGCC TTGGCAGGTC 
CTAAGCAAAG GGGACAAGGA AGAAGTTGCC TATGAAGAAA GGGCCTGTGA AGGCGGCAAA 
TTTGCCACAG TAGAAGTGAC AGATAAGCCT GTGGATGAGG CTCTACGGGA AGCAATGCCC 
AAGGTCGCAA AGTATGCGGG GGGCACCAAT GACAAGGGAA TTGGGATGGG GATGACAGTC 
CCTATTTCCT TTGCTGTGTT CCCCAATGAA GATGGCTCTC TGCAGAAGAA ATTAAAAGTC 
TGGTTCCGGA TTCCAAACCA ATTTCAAAGC GACCCACCAG CTCCCAGTGA CAAAAGCGTT 
AAGATTGAGG AACGGGAAGG CATCACTGTC TATTCCATGC AGTTTGGTGG TTATGCCAAG 
GAAGCAGACT ACGTAGCACA AGCCACCCGT CTGCGTGCTG CCCTGGAGGG CACAGCCACC 
TACCGGGGGG ACATCTACTT CTGCACGGGT TATGACCCTC CCATGAAGCC CTACGGACGG 
CGCAATGAGA TCTGGCTGTT GAAGACATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_057071.2
CDS	196..765
Translation	MLGMIKNSLFGSVETWPWQVLSKGDKEEVAYEERACEGGKFATVEVTDKPVDEALREAMPKVAKYAGGTNDKGIGMGMTVPISFAVFPNEDGSLQKKLKVWFRIPNQFQSDPPAPSDKSVKIEEREGITVYSMQFGGYAKEADYVAQATRLRAALEGTATYRGDIYFCTGYDPPMKPYGRRNEIWLLKT

Target ORF information:

RefSeq Version	NM_015987.4
Organism	Homo sapiens(human)
Definition	Homo sapiens heme binding protein 1 (HEBP1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_015987.4

ORF Insert Sequence:

ATGTTGGGCA TGATCAAGAA CTCGCTGTTC GGAAGCGTAG AGACGTGGCC TTGGCAGGTC 
CTAAGCAAAG GGGACAAGGA AGAAGTTGCC TATGAAGAAA GGGCCTGTGA AGGCGGCAAA 
TTTGCCACAG TAGAAGTGAC AGATAAGCCT GTGGATGAGG CTCTACGGGA AGCAATGCCC 
AAGGTCGCAA AGTATGCGGG GGGCACCAAT GACAAGGGAA TTGGGATGGG GATGACAGTC 
CCTATTTCCT TTGCTGTGTT CCCCAATGAA GATGGCTCTC TGCAGAAGAA ATTAAAAGTC 
TGGTTCCGGA TTCCAAACCA ATTTCAAAGC GACCCACCAG CTCCCAGTGA CAAAAGCGTT 
AAGATTGAGG AACGGGAAGG CATCACTGTC TATTCCATGC AGTTTGGTGG TTATGCCAAG 
GAAGCAGACT ACGTAGCACA AGCCACCCGT CTGCGTGCTG CCCTGGAGGG CACAGCCACC 
TACCGGGGGG ACATCTACTT CTGCACGGGT TATGACCCTC CCATGAAGCC CTACGGACGG 
CGCAATGAGA TCTGGCTGTT GAAGACATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HEBP1 ( NM_015987.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_057071.2 Homo sapiens heme binding protein 1 (HEBP1), mRNA.

Price & Availability↑

CloneID	OHu11165
Clone ID Related Accession (Same CDS sequence)	NM_015987.4 , NM_015987.5
Accession Version	NM_015987.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 570bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-25
Organism	Homo sapiens(human)
Product	heme-binding protein 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CF126276.1, AC007688.15 and AW452041.1. On Nov 22, 2018 this sequence version replaced NM_015987.4. ##Evidence-Data-START## Transcript exon combination :: ERR279873.4554.1, SRR3476690.869805.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000014930.9/ ENSP00000014930.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGTTGGGCA TGATCAAGAA CTCGCTGTTC GGAAGCGTAG AGACGTGGCC TTGGCAGGTC 
CTAAGCAAAG GGGACAAGGA AGAAGTTGCC TATGAAGAAA GGGCCTGTGA AGGCGGCAAA 
TTTGCCACAG TAGAAGTGAC AGATAAGCCT GTGGATGAGG CTCTACGGGA AGCAATGCCC 
AAGGTCGCAA AGTATGCGGG GGGCACCAAT GACAAGGGAA TTGGGATGGG GATGACAGTC 
CCTATTTCCT TTGCTGTGTT CCCCAATGAA GATGGCTCTC TGCAGAAGAA ATTAAAAGTC 
TGGTTCCGGA TTCCAAACCA ATTTCAAAGC GACCCACCAG CTCCCAGTGA CAAAAGCGTT 
AAGATTGAGG AACGGGAAGG CATCACTGTC TATTCCATGC AGTTTGGTGG TTATGCCAAG 
GAAGCAGACT ACGTAGCACA AGCCACCCGT CTGCGTGCTG CCCTGGAGGG CACAGCCACC 
TACCGGGGGG ACATCTACTT CTGCACGGGT TATGACCCTC CCATGAAGCC CTACGGACGG 
CGCAATGAGA TCTGGCTGTT GAAGACATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_057071.2
CDS	152..721
Translation	MLGMIKNSLFGSVETWPWQVLSKGDKEEVAYEERACEGGKFATVEVTDKPVDEALREAMPKVAKYAGGTNDKGIGMGMTVPISFAVFPNEDGSLQKKLKVWFRIPNQFQSDPPAPSDKSVKIEEREGITVYSMQFGGYAKEADYVAQATRLRAALEGTATYRGDIYFCTGYDPPMKPYGRRNEIWLLKT

Target ORF information:

RefSeq Version	NM_015987.5
Organism	Homo sapiens(human)
Definition	Homo sapiens heme binding protein 1 (HEBP1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_015987.5

ORF Insert Sequence:

ATGTTGGGCA TGATCAAGAA CTCGCTGTTC GGAAGCGTAG AGACGTGGCC TTGGCAGGTC 
CTAAGCAAAG GGGACAAGGA AGAAGTTGCC TATGAAGAAA GGGCCTGTGA AGGCGGCAAA 
TTTGCCACAG TAGAAGTGAC AGATAAGCCT GTGGATGAGG CTCTACGGGA AGCAATGCCC 
AAGGTCGCAA AGTATGCGGG GGGCACCAAT GACAAGGGAA TTGGGATGGG GATGACAGTC 
CCTATTTCCT TTGCTGTGTT CCCCAATGAA GATGGCTCTC TGCAGAAGAA ATTAAAAGTC 
TGGTTCCGGA TTCCAAACCA ATTTCAAAGC GACCCACCAG CTCCCAGTGA CAAAAGCGTT 
AAGATTGAGG AACGGGAAGG CATCACTGTC TATTCCATGC AGTTTGGTGG TTATGCCAAG 
GAAGCAGACT ACGTAGCACA AGCCACCCGT CTGCGTGCTG CCCTGGAGGG CACAGCCACC 
TACCGGGGGG ACATCTACTT CTGCACGGGT TATGACCCTC CCATGAAGCC CTACGGACGG 
CGCAATGAGA TCTGGCTGTT GAAGACATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Processing of HEBP1 by cathepsin D gives rise to F2L, the agonist of formyl peptide receptor 3.
Journal of immunology (Baltimore, Md. : 1950)187(3)1475-85(2011 Aug)
Devosse T,Dutoit R,Migeotte I,De Nadai P,Imbault V,Communi D,Salmon I,Parmentier M

Tetrapyrrole binding affinity of the murine and human p22HBP heme-binding proteins.
Journal of molecular graphics & modelling29(3)396-405(2010 Nov)
Micaelo NM,Macedo AL,Goodfellow BJ,F?lix V

Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Diabetes care33(10)2250-3(2010 Oct)
Bailey SD,Xie C,Do R,Montpetit A,Diaz R,Mohan V,Keavney B,Yusuf S,Gerstein HC,Engert JC,Anand S,

Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
American journal of human genetics85(5)628-42(2009 Nov)
Talmud PJ,Drenos F,Shah S,Shah T,Palmen J,Verzilli C,Gaunt TR,Pallas J,Lovering R,Li K,Casas JP,Sofat R,Kumari M,Rodriguez S,Johnson T,Newhouse SJ,Dominiczak A,Samani NJ,Caulfield M,Sever P,Stanton A,Shields DC,Padmanabhan S,Melander O,Hastie C,Delles C,Ebrahim S,Marmot MG,Smith GD,Lawlor DA,Munroe PB,Day IN,Kivimaki M,Whittaker J,Humphries SE,Hingorani AD,,,

Large-scale proteomics and phosphoproteomics of urinary exosomes.
Journal of the American Society of Nephrology : JASN20(2)363-79(2009 Feb)
Gonzales PA,Pisitkun T,Hoffert JD,Tchapyjnikov D,Star RA,Kleta R,Wang NS,Knepper MA

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HEBP1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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