TAS2R10 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	TAS2R10
Entrez Gene ID	50839
Full Name	taste 2 receptor member 10
Synonyms	T2R10,TRB2
General protein information	Preferred Names taste 2 receptor member 10 Names taste receptor type 2 member 10 taste receptor, family B, member 2 taste receptor, type 2, member 10
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 12 Map Location: 12p13.2
Summary	This gene product belongs to the family of candidate taste receptors that are members of the G-protein-coupled receptor superfamily. These proteins are specifically expressed in the taste receptor cells of the tongue and palate epithelia. They are organized in the genome in clusters and are genetically linked to loci that influence bitter perception in mice and humans. In functional expression studies, they respond to bitter tastants. This gene maps to the taste receptor gene cluster on chromosome 12p13. [provided by RefSeq, Jul 2008].
Disorder MIM:	604791

mRNA and Protein(s)

mRNA	Protein	Name
NM_023921.1	NP_076410.1	taste receptor type 2 member 10

Pathways from BioSystems

Homologies

	TAS2R10	XP_001115483.1
Canis lupus familiaris (dog)	TAS2R10	NP_001138969.1
Bos taurus (cattle)	TAS2R10	NP_001040091.1
Pan troglodytes (chimpanzee)	TAS2R10	NP_001009142.1
Rattus norvegicus (Norway rat)	Tas2r114	NP_076486.1
Homo sapiens (human)	TAS2R10	NP_076410.1
Bos taurus (cattle)	BOTA-T2R10B	NP_001040092.1
Mus musculus (house mouse)	Tas2r114	NP_996902.1

Gene Ontology
Bibliography

Related articles in PubMed

Anti-cancer stemness and anti-invasive activity of bitter taste receptors, TAS2R8 and TAS2R10, in human neuroblastoma cells.
Seo Y, Kim YS, Lee KE, Park TH, Kim Y
PloS one12(5)e0176851(2017)

The human bitter taste receptor TAS2R10 is tailored to accommodate numerous diverse ligands.
Born S, Levit A, Niv MY, Meyerhof W, Behrens M
The Journal of neuroscience : the official journal of the Society for Neuroscience33(1)201-13(2013 Jan)

The molecular receptive ranges of human TAS2R bitter taste receptors.
Meyerhof W, Batram C, Kuhn C, Brockhoff A, Chudoba E, Bufe B, Appendino G, Behrens M
Chemical senses35(2)157-70(2010 Feb)

Lineage-specific loss of function of bitter taste receptor genes in humans and nonhuman primates.
Go Y, Satta Y, Takenaka O, Takahata N
Genetics170(1)313-26(2005 May)

The receptors and coding logic for bitter taste.
Mueller KL, Hoon MA, Erlenbach I, Chandrashekar J, Zuker CS, Ryba NJ
Nature434(7030)225-9(2005 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

targets cancer stem cells by suppressing cancer stemness characteristics and neuroblastoma cell invasion
Title: Anti-cancer stemness and anti-invasive activity of bitter taste receptors, TAS2R8 and TAS2R10, in human neuroblastoma cells.

The human bitter taste receptor TAS2R10 is tailored to accommodate numerous diverse ligands
Title: The human bitter taste receptor TAS2R10 is tailored to accommodate numerous diverse ligands.

The following TAS2R10 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TAS2R10 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu31162	NM_023921.1 Latest version!	Homo sapiens taste 2 receptor member 10 (TAS2R10), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$154.50-$216.30 $309.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

TAS2R10 ( NM_023921.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_076410.1 Homo sapiens taste 2 receptor member 10 (TAS2R10), mRNA.

Price & Availability↑

CloneID	OHu31162
Clone ID Related Accession (Same CDS sequence)	NM_023921.1
Accession Version	NM_023921.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 924bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-21
Organism	Homo sapiens(human)
Product	taste receptor type 2 member 10
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF227136.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: BC069089.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##

ATGCTACGTG TAGTGGAAGG CATCTTCATT TTTGTTGTAG TTAGTGAGTC AGTGTTTGGG 
GTTTTGGGGA ATGGATTTAT TGGACTTGTA AACTGCATTG ACTGTGCCAA GAATAAGTTA 
TCTACGATTG GCTTTATTCT CACCGGCTTA GCTATTTCAA GAATTTTTCT GATATGGATA 
ATAATTACAG ATGGATTTAT ACAGATATTC TCTCCAAATA TATATGCCTC CGGTAACCTA 
ATTGAATATA TTAGTTACTT TTGGGTAATT GGTAATCAAT CAAGTATGTG GTTTGCCACC 
AGCCTCAGCA TCTTCTATTT CCTGAAGATA GCAAATTTTT CCAACTACAT ATTTCTCTGG 
TTGAAGAGCA GAACAAATAT GGTTCTTCCC TTCATGATAG TATTCTTACT TATTTCATCG 
TTACTTAATT TTGCATACAT TGCGAAGATT CTTAATGATT ATAAAACGAA GAATGACACA 
GTCTGGGATC TCAACATGTA TAAAAGTGAA TACTTTATTA AACAGATTTT GCTAAATCTG 
GGAGTCATTT TCTTCTTTAC ACTATCCCTA ATTACATGTA TTTTTTTAAT CATTTCCCTT 
TGGAGACACA ACAGGCAGAT GCAATCGAAT GTGACAGGAT TGAGAGACTC CAACACAGAA 
GCTCATGTGA AGGCAATGAA AGTTTTGATA TCTTTCATCA TCCTCTTTAT CTTGTATTTT 
ATAGGCATGG CCATAGAAAT ATCATGTTTT ACTGTGCGAG AAAACAAACT GCTGCTTATG 
TTTGGAATGA CAACCACAGC CATCTATCCC TGGGGTCACT CATTTATCTT AATTCTAGGA 
AACAGCAAGC TAAAGCAAGC CTCTTTGAGG GTACTGCAGC AATTGAAGTG CTGTGAGAAA 
AGGAAAAATC TCAGAGTCAC ATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_076410.1
CDS	1..924
Translation	MLRVVEGIFIFVVVSESVFGVLGNGFIGLVNCIDCAKNKLSTIGFILTGLAISRIFLIWIIITDGFIQIFSPNIYASGNLIEYISYFWVIGNQSSMWFATSLSIFYFLKIANFSNYIFLWLKSRTNMVLPFMIVFLLISSLLNFAYIAKILNDYKTKNDTVWDLNMYKSEYFIKQILLNLGVIFFFTLSLITCIFLIISLWRHNRQMQSNVTGLRDSNTEAHVKAMKVLISFIILFILYFIGMAIEISCFTVRENKLLLMFGMTTTAIYPWGHSFILILGNSKLKQASLRVLQQLKCCEKRKNLRVT

Target ORF information:

RefSeq Version	NM_023921.1
Organism	Homo sapiens(human)
Definition	Homo sapiens taste 2 receptor member 10 (TAS2R10), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_023921.1

ORF Insert Sequence:

ATGCTACGTG TAGTGGAAGG CATCTTCATT TTTGTTGTAG TTAGTGAGTC AGTGTTTGGG 
GTTTTGGGGA ATGGATTTAT TGGACTTGTA AACTGCATTG ACTGTGCCAA GAATAAGTTA 
TCTACGATTG GCTTTATTCT CACCGGCTTA GCTATTTCAA GAATTTTTCT GATATGGATA 
ATAATTACAG ATGGATTTAT ACAGATATTC TCTCCAAATA TATATGCCTC CGGTAACCTA 
ATTGAATATA TTAGTTACTT TTGGGTAATT GGTAATCAAT CAAGTATGTG GTTTGCCACC 
AGCCTCAGCA TCTTCTATTT CCTGAAGATA GCAAATTTTT CCAACTACAT ATTTCTCTGG 
TTGAAGAGCA GAACAAATAT GGTTCTTCCC TTCATGATAG TATTCTTACT TATTTCATCG 
TTACTTAATT TTGCATACAT TGCGAAGATT CTTAATGATT ATAAAACGAA GAATGACACA 
GTCTGGGATC TCAACATGTA TAAAAGTGAA TACTTTATTA AACAGATTTT GCTAAATCTG 
GGAGTCATTT TCTTCTTTAC ACTATCCCTA ATTACATGTA TTTTTTTAAT CATTTCCCTT 
TGGAGACACA ACAGGCAGAT GCAATCGAAT GTGACAGGAT TGAGAGACTC CAACACAGAA 
GCTCATGTGA AGGCAATGAA AGTTTTGATA TCTTTCATCA TCCTCTTTAT CTTGTATTTT 
ATAGGCATGG CCATAGAAAT ATCATGTTTT ACTGTGCGAG AAAACAAACT GCTGCTTATG 
TTTGGAATGA CAACCACAGC CATCTATCCC TGGGGTCACT CATTTATCTT AATTCTAGGA 
AACAGCAAGC TAAAGCAAGC CTCTTTGAGG GTACTGCAGC AATTGAAGTG CTGTGAGAAA 
AGGAAAAATC TCAGAGTCAC ATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Anti-cancer stemness and anti-invasive activity of bitter taste receptors, TAS2R8 and TAS2R10, in human neuroblastoma cells.
PloS one12(5)e0176851(2017)
Seo Y,Kim YS,Lee KE,Park TH,Kim Y

The human bitter taste receptor TAS2R10 is tailored to accommodate numerous diverse ligands.
The Journal of neuroscience : the official journal of the Society for Neuroscience33(1)201-13(2013 Jan)
Born S,Levit A,Niv MY,Meyerhof W,Behrens M

The molecular receptive ranges of human TAS2R bitter taste receptors.
Chemical senses35(2)157-70(2010 Feb)
Meyerhof W,Batram C,Kuhn C,Brockhoff A,Chudoba E,Bufe B,Appendino G,Behrens M

Lineage-specific loss of function of bitter taste receptor genes in humans and nonhuman primates.
Genetics170(1)313-26(2005 May)
Go Y,Satta Y,Takenaka O,Takahata N

The receptors and coding logic for bitter taste.
Nature434(7030)225-9(2005 Mar)
Mueller KL,Hoon MA,Erlenbach I,Chandrashekar J,Zuker CS,Ryba NJ

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TAS2R10 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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