TAS2R7 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	TAS2R7
Entrez Gene ID	50837
Full Name	taste 2 receptor member 7
Synonyms	T2R7,TRB4
General protein information	Preferred Names taste 2 receptor member 7 Names taste receptor type 2 member 7 taste receptor, family B, member 4 taste receptor, type 2, member 7
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 12 Map Location: 12p13.2
Summary	This gene product belongs to the family of candidate taste receptors that are members of the G-protein-coupled receptor superfamily. These proteins are specifically expressed in the taste receptor cells of the tongue and palate epithelia. They are organized in the genome in clusters and are genetically linked to loci that influence bitter perception in mice and humans. In functional expression studies, they respond to bitter tastants. This gene maps to the taste receptor gene cluster on chromosome 12p13. [provided by RefSeq, Jul 2008].
Disorder MIM:	604793

mRNA and Protein(s)

mRNA	Protein	Name
NM_023919.2	NP_076408.1	taste receptor type 2 member 7

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Tas2r130	NP_954607.1
Canis lupus familiaris (dog)	TAS2R7	NP_001138974.1
Bos taurus (cattle)	TAS2R7	XP_002687839.3
Rattus norvegicus (Norway rat)	Tas2r130	XP_001074122.1
Homo sapiens (human)	TAS2R7	NP_076408.1
Pan troglodytes (chimpanzee)	TAS2R7	XP_520745.1
	TAS2R7	NP_001074235.1

Gene Ontology
Bibliography

Related articles in PubMed

Plasticity of the ligand binding pocket in the bitter taste receptor T2R7.
Liu K, Jaggupilli A, Premnath D, Chelikani P
Biochimica et biophysica acta(2018 Jan)

The molecular receptive ranges of human TAS2R bitter taste receptors.
Meyerhof W, Batram C, Kuhn C, Brockhoff A, Chudoba E, Bufe B, Appendino G, Behrens M
Chemical senses35(2)157-70(2010 Feb)

Lineage-specific loss of function of bitter taste receptor genes in humans and nonhuman primates.
Go Y, Satta Y, Takenaka O, Takahata N
Genetics170(1)313-26(2005 May)

Evolution of bitter taste receptors in humans and apes.
Fischer A, Gilad Y, Man O, P??bo S
Molecular biology and evolution22(3)432-6(2005 Mar)

Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways.
Zhang Y, Hoon MA, Chandrashekar J, Mueller KL, Cook B, Wu D, Zuker CS, Ryba NJ
Cell112(3)293-301(2003 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following TAS2R7 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TAS2R7 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu29756	NM_023919.2 Latest version!	Homo sapiens taste 2 receptor member 7 (TAS2R7), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$154.50-$216.30 $309.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

TAS2R7 ( NM_023919.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_076408.1 Homo sapiens taste 2 receptor member 7 (TAS2R7), mRNA.

Price & Availability↑

CloneID	OHu29756
Clone ID Related Accession (Same CDS sequence)	NM_023919.2
Accession Version	NM_023919.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 957bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-20
Organism	Homo sapiens(human)
Product	taste receptor type 2 member 7
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC093992.1 and BC069091.1. On Jun 23, 2005 this sequence version replaced NM_023919.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: BC093992.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000240687.2/ ENSP00000240687.2 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##

ATGGCAGATA AAGTGCAGAC TACTTTATTG TTCTTAGCAG TTGGAGAGTT TTCAGTGGGG 
ATCTTAGGGA ATGCATTCAT TGGATTGGTA AACTGCATGG ACTGGGTCAA GAAGAGGAAA 
ATTGCCTCCA TTGATTTAAT CCTCACAAGT CTGGCCATAT CCAGAATTTG TCTATTGTGC 
GTAATACTAT TAGATTGTTT TATATTGGTG CTATATCCAG ATGTCTATGC CACTGGTAAA 
GAAATGAGAA TCATTGACTT CTTCTGGACA CTAACCAATC ATTTAAGTAT CTGGTTTGCA 
ACCTGCCTCA GCATTTACTA TTTCTTCAAG ATAGGTAATT TCTTTCACCC ACTTTTCCTC 
TGGATGAAGT GGAGAATTGA CAGGGTGATT TCCTGGATTC TACTGGGGTG CGTGGTTCTC 
TCTGTGTTTA TTAGCCTTCC AGCCACTGAG AATTTGAACG CTGATTTCAG GTTTTGTGTG 
AAGGCAAAGA GGAAAACAAA CTTAACTTGG AGTTGCAGAG TAAATAAAAC TCAACATGCT 
TCTACCAAGT TATTTCTCAA CCTGGCAACG CTGCTCCCCT TTTGTGTGTG CCTAATGTCC 
TTTTTCCTCT TGATCCTCTC CCTGCGGAGA CATATCAGGC GAATGCAGCT CAGTGCCACA 
GGGTGCAGAG ACCCCAGCAC AGAAGCCCAT GTGAGAGCCC TGAAAGCTGT CATTTCCTTC 
CTTCTCCTCT TTATTGCCTA CTATTTGTCC TTTCTCATTG CCACCTCCAG CTACTTTATG 
CCAGAGACGG AATTAGCTGT GATTTTTGGT GAGTCCATAG CTCTAATCTA CCCCTCAAGT 
CATTCATTTA TCCTAATACT GGGGAACAAT AAATTAAGAC ATGCATCTCT AAAGGTGATT 
TGGAAAGTAA TGTCTATTCT AAAAGGAAGA AAATTCCAAC AACATAAACA AATCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_076408.1
CDS	58..1014
Translation	MADKVQTTLLFLAVGEFSVGILGNAFIGLVNCMDWVKKRKIASIDLILTSLAISRICLLCVILLDCFILVLYPDVYATGKEMRIIDFFWTLTNHLSIWFATCLSIYYFFKIGNFFHPLFLWMKWRIDRVISWILLGCVVLSVFISLPATENLNADFRFCVKAKRKTNLTWSCRVNKTQHASTKLFLNLATLLPFCVCLMSFFLLILSLRRHIRRMQLSATGCRDPSTEAHVRALKAVISFLLLFIAYYLSFLIATSSYFMPETELAVIFGESIALIYPSSHSFILILGNNKLRHASLKVIWKVMSILKGRKFQQHKQI

Target ORF information:

RefSeq Version	NM_023919.2
Organism	Homo sapiens(human)
Definition	Homo sapiens taste 2 receptor member 7 (TAS2R7), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_023919.2

ORF Insert Sequence:

ATGGCAGATA AAGTGCAGAC TACTTTATTG TTCTTAGCAG TTGGAGAGTT TTCAGTGGGG 
ATCTTAGGGA ATGCATTCAT TGGATTGGTA AACTGCATGG ACTGGGTCAA GAAGAGGAAA 
ATTGCCTCCA TTGATTTAAT CCTCACAAGT CTGGCCATAT CCAGAATTTG TCTATTGTGC 
GTAATACTAT TAGATTGTTT TATATTGGTG CTATATCCAG ATGTCTATGC CACTGGTAAA 
GAAATGAGAA TCATTGACTT CTTCTGGACA CTAACCAATC ATTTAAGTAT CTGGTTTGCA 
ACCTGCCTCA GCATTTACTA TTTCTTCAAG ATAGGTAATT TCTTTCACCC ACTTTTCCTC 
TGGATGAAGT GGAGAATTGA CAGGGTGATT TCCTGGATTC TACTGGGGTG CGTGGTTCTC 
TCTGTGTTTA TTAGCCTTCC AGCCACTGAG AATTTGAACG CTGATTTCAG GTTTTGTGTG 
AAGGCAAAGA GGAAAACAAA CTTAACTTGG AGTTGCAGAG TAAATAAAAC TCAACATGCT 
TCTACCAAGT TATTTCTCAA CCTGGCAACG CTGCTCCCCT TTTGTGTGTG CCTAATGTCC 
TTTTTCCTCT TGATCCTCTC CCTGCGGAGA CATATCAGGC GAATGCAGCT CAGTGCCACA 
GGGTGCAGAG ACCCCAGCAC AGAAGCCCAT GTGAGAGCCC TGAAAGCTGT CATTTCCTTC 
CTTCTCCTCT TTATTGCCTA CTATTTGTCC TTTCTCATTG CCACCTCCAG CTACTTTATG 
CCAGAGACGG AATTAGCTGT GATTTTTGGT GAGTCCATAG CTCTAATCTA CCCCTCAAGT 
CATTCATTTA TCCTAATACT GGGGAACAAT AAATTAAGAC ATGCATCTCT AAAGGTGATT 
TGGAAAGTAA TGTCTATTCT AAAAGGAAGA AAATTCCAAC AACATAAACA AATCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Plasticity of the ligand binding pocket in the bitter taste receptor T2R7.
Biochimica et biophysica acta(2018 Jan)
Liu K,Jaggupilli A,Premnath D,Chelikani P

The molecular receptive ranges of human TAS2R bitter taste receptors.
Chemical senses35(2)157-70(2010 Feb)
Meyerhof W,Batram C,Kuhn C,Brockhoff A,Chudoba E,Bufe B,Appendino G,Behrens M

Lineage-specific loss of function of bitter taste receptor genes in humans and nonhuman primates.
Genetics170(1)313-26(2005 May)
Go Y,Satta Y,Takenaka O,Takahata N

Evolution of bitter taste receptors in humans and apes.
Molecular biology and evolution22(3)432-6(2005 Mar)
Fischer A,Gilad Y,Man O,P??bo S

Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways.
Cell112(3)293-301(2003 Feb)
Zhang Y,Hoon MA,Chandrashekar J,Mueller KL,Cook B,Wu D,Zuker CS,Ryba NJ

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TAS2R7 cDNA ORF clone, Homo sapiens(human)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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