TAS2R8 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	TAS2R8
Entrez Gene ID	50836
Full Name	taste 2 receptor member 8
Synonyms	T2R8,TRB5
General protein information	Preferred Names taste 2 receptor member 8 Names taste receptor type 2 member 8 taste receptor, family B, member 5 taste receptor, type 2, member 8
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 12 Map Location: 12p13.2
Summary	This gene product belongs to the family of candidate taste receptors that are members of the G-protein-coupled receptor superfamily. These proteins are specifically expressed in the taste receptor cells of the tongue and palate epithelia. They are organized in the genome in clusters and are genetically linked to loci that influence bitter perception in mice and humans. In functional expression studies, they respond to bitter tastants. This gene maps to the taste receptor gene cluster on chromosome 12p13. [provided by RefSeq, Jul 2008].
Disorder MIM:	604794

mRNA and Protein(s)

mRNA	Protein	Name
NM_023918.1	NP_076407.1	taste receptor type 2 member 8
NM_023918.2	NP_076407.1	taste receptor type 2 member 8

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	TAS2R8	XP_005637491.1
Pan troglodytes (chimpanzee)	TAS2R8	XP_001150153.1
Homo sapiens (human)	TAS2R8	NP_076407.1
	LOC717924	XP_001115454.1

Gene Ontology
Bibliography

Related articles in PubMed

Anti-cancer stemness and anti-invasive activity of bitter taste receptors, TAS2R8 and TAS2R10, in human neuroblastoma cells.
Seo Y, Kim YS, Lee KE, Park TH, Kim Y
PloS one12(5)e0176851(2017)

Human bitter taste receptors hTAS2R8 and hTAS2R39 with differential functions to recognize bitter peptides.
Ueno Y, Sakurai T, Okada S, Abe K, Misaka T
Bioscience, biotechnology, and biochemistry75(6)1188-90(2011)

The molecular receptive ranges of human TAS2R bitter taste receptors.
Meyerhof W, Batram C, Kuhn C, Brockhoff A, Chudoba E, Bufe B, Appendino G, Behrens M
Chemical senses35(2)157-70(2010 Feb)

Lineage-specific loss of function of bitter taste receptor genes in humans and nonhuman primates.
Go Y, Satta Y, Takenaka O, Takahata N
Genetics170(1)313-26(2005 May)

Evolution of bitter taste receptors in humans and apes.
Fischer A, Gilad Y, Man O, P??bo S
Molecular biology and evolution22(3)432-6(2005 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

targets cancer stem cells by suppressing cancer stemness characteristics and neuroblastoma cell invasion
Title: Anti-cancer stemness and anti-invasive activity of bitter taste receptors, TAS2R8 and TAS2R10, in human neuroblastoma cells.

Human bitter taste receptors hTAS2R8 and hTAS2R39 display differential functions to recognize bitter peptides.
Title: Human bitter taste receptors hTAS2R8 and hTAS2R39 with differential functions to recognize bitter peptides.

The following TAS2R8 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TAS2R8 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu29321	NM_023918.2 Latest version!	Homo sapiens taste 2 receptor member 8 (TAS2R8), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$154.50-$216.30 $309.00
View Old Accession Versions >>
OHu29321	NM_023918.1	Homo sapiens taste 2 receptor member 8 (TAS2R8), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$154.50-$216.30 $309.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

TAS2R8 ( NM_023918.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_076407.1 Homo sapiens taste 2 receptor member 8 (TAS2R8), mRNA.

Price & Availability↑

CloneID	OHu29321
Clone ID Related Accession (Same CDS sequence)	NM_023918.1 , NM_023918.2
Accession Version	NM_023918.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 930bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-05-03
Organism	Homo sapiens(human)
Product	taste receptor type 2 member 8
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF227134.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: BC069084.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##

ATGTTCAGTC CTGCAGATAA CATCTTTATA ATCCTAATAA CTGGAGAATT CATACTAGGA 
ATATTGGGGA ATGGATACAT TGCACTAGTC AACTGGATTG ACTGGATTAA GAAGAAAAAG 
ATTTCCACAG TTGACTACAT CCTTACCAAT TTAGTTATCG CCAGAATTTG TTTGATCAGT 
GTAATGGTTG TAAATGGCAT TGTAATAGTA CTGAACCCAG ATGTTTATAC AAAAAATAAA 
CAACAGATAG TCATTTTTAC CTTCTGGACA TTTGCCAACT ACTTAAATAT GTGGATTACC 
ACCTGCCTTA ATGTCTTCTA TTTTCTGAAG ATAGCCAGTT CCTCTCATCC ACTTTTTCTC 
TGGCTGAAGT GGAAAATTGA TATGGTGGTG CACTGGATCC TGCTGGGATG CTTTGCCATT 
TCCTTGTTGG TCAGCCTTAT AGCAGCAATA GTACTGAGTT GTGATTATAG GTTTCATGCA 
ATTGCCAAAC ATAAAAGAAA CATTACTGAA ATGTTCCATG TGAGTAAAAT ACCATACTTT 
GAACCCTTGA CTCTCTTTAA CCTGTTTGCA ATTGTCCCAT TTATTGTGTC ACTGATATCA 
TTTTTCCTTT TAGTAAGATC TTTATGGAGA CATACCAAGC AAATAAAACT CTATGCTACC 
GGCAGTAGAG ACCCCAGCAC AGAAGTTCAT GTGAGAGCCA TTAAAACTAT GACTTCATTT 
ATCTTCTTTT TTTTCCTATA CTATATTTCT TCTATTTTGA TGACCTTTAG CTATCTTATG 
ACAAAATACA AGTTAGCTGT GGAGTTTGGA GAGATTGCAG CAATTCTCTA CCCCTTGGGT 
CACTCACTTA TTTTAATTGT TTTAAATAAT AAACTGAGGC AGACATTTGT CAGAATGCTG 
ACATGTAGAA AAATTGCCTG CATGATATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_076407.1
CDS	1..930
Translation	MFSPADNIFIILITGEFILGILGNGYIALVNWIDWIKKKKISTVDYILTNLVIARICLISVMVVNGIVIVLNPDVYTKNKQQIVIFTFWTFANYLNMWITTCLNVFYFLKIASSSHPLFLWLKWKIDMVVHWILLGCFAISLLVSLIAAIVLSCDYRFHAIAKHKRNITEMFHVSKIPYFEPLTLFNLFAIVPFIVSLISFFLLVRSLWRHTKQIKLYATGSRDPSTEVHVRAIKTMTSFIFFFFLYYISSILMTFSYLMTKYKLAVEFGEIAAILYPLGHSLILIVLNNKLRQTFVRMLTCRKIACMI

Target ORF information:

RefSeq Version	NM_023918.1
Organism	Homo sapiens(human)
Definition	Homo sapiens taste 2 receptor member 8 (TAS2R8), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_023918.1

ORF Insert Sequence:

ATGTTCAGTC CTGCAGATAA CATCTTTATA ATCCTAATAA CTGGAGAATT CATACTAGGA 
ATATTGGGGA ATGGATACAT TGCACTAGTC AACTGGATTG ACTGGATTAA GAAGAAAAAG 
ATTTCCACAG TTGACTACAT CCTTACCAAT TTAGTTATCG CCAGAATTTG TTTGATCAGT 
GTAATGGTTG TAAATGGCAT TGTAATAGTA CTGAACCCAG ATGTTTATAC AAAAAATAAA 
CAACAGATAG TCATTTTTAC CTTCTGGACA TTTGCCAACT ACTTAAATAT GTGGATTACC 
ACCTGCCTTA ATGTCTTCTA TTTTCTGAAG ATAGCCAGTT CCTCTCATCC ACTTTTTCTC 
TGGCTGAAGT GGAAAATTGA TATGGTGGTG CACTGGATCC TGCTGGGATG CTTTGCCATT 
TCCTTGTTGG TCAGCCTTAT AGCAGCAATA GTACTGAGTT GTGATTATAG GTTTCATGCA 
ATTGCCAAAC ATAAAAGAAA CATTACTGAA ATGTTCCATG TGAGTAAAAT ACCATACTTT 
GAACCCTTGA CTCTCTTTAA CCTGTTTGCA ATTGTCCCAT TTATTGTGTC ACTGATATCA 
TTTTTCCTTT TAGTAAGATC TTTATGGAGA CATACCAAGC AAATAAAACT CTATGCTACC 
GGCAGTAGAG ACCCCAGCAC AGAAGTTCAT GTGAGAGCCA TTAAAACTAT GACTTCATTT 
ATCTTCTTTT TTTTCCTATA CTATATTTCT TCTATTTTGA TGACCTTTAG CTATCTTATG 
ACAAAATACA AGTTAGCTGT GGAGTTTGGA GAGATTGCAG CAATTCTCTA CCCCTTGGGT 
CACTCACTTA TTTTAATTGT TTTAAATAAT AAACTGAGGC AGACATTTGT CAGAATGCTG 
ACATGTAGAA AAATTGCCTG CATGATATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TAS2R8 ( NM_023918.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_076407.1 Homo sapiens taste 2 receptor member 8 (TAS2R8), mRNA.

Price & Availability↑

CloneID	OHu29321
Clone ID Related Accession (Same CDS sequence)	NM_023918.1 , NM_023918.2
Accession Version	NM_023918.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 930bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-01
Organism	Homo sapiens(human)
Product	taste receptor type 2 member 8
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC006518.17. On Dec 2, 2019 this sequence version replaced NM_023918.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: BC096735.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##

ATGTTCAGTC CTGCAGATAA CATCTTTATA ATCCTAATAA CTGGAGAATT CATACTAGGA 
ATATTGGGGA ATGGATACAT TGCACTAGTC AACTGGATTG ACTGGATTAA GAAGAAAAAG 
ATTTCCACAG TTGACTACAT CCTTACCAAT TTAGTTATCG CCAGAATTTG TTTGATCAGT 
GTAATGGTTG TAAATGGCAT TGTAATAGTA CTGAACCCAG ATGTTTATAC AAAAAATAAA 
CAACAGATAG TCATTTTTAC CTTCTGGACA TTTGCCAACT ACTTAAATAT GTGGATTACC 
ACCTGCCTTA ATGTCTTCTA TTTTCTGAAG ATAGCCAGTT CCTCTCATCC ACTTTTTCTC 
TGGCTGAAGT GGAAAATTGA TATGGTGGTG CACTGGATCC TGCTGGGATG CTTTGCCATT 
TCCTTGTTGG TCAGCCTTAT AGCAGCAATA GTACTGAGTT GTGATTATAG GTTTCATGCA 
ATTGCCAAAC ATAAAAGAAA CATTACTGAA ATGTTCCATG TGAGTAAAAT ACCATACTTT 
GAACCCTTGA CTCTCTTTAA CCTGTTTGCA ATTGTCCCAT TTATTGTGTC ACTGATATCA 
TTTTTCCTTT TAGTAAGATC TTTATGGAGA CATACCAAGC AAATAAAACT CTATGCTACC 
GGCAGTAGAG ACCCCAGCAC AGAAGTTCAT GTGAGAGCCA TTAAAACTAT GACTTCATTT 
ATCTTCTTTT TTTTCCTATA CTATATTTCT TCTATTTTGA TGACCTTTAG CTATCTTATG 
ACAAAATACA AGTTAGCTGT GGAGTTTGGA GAGATTGCAG CAATTCTCTA CCCCTTGGGT 
CACTCACTTA TTTTAATTGT TTTAAATAAT AAACTGAGGC AGACATTTGT CAGAATGCTG 
ACATGTAGAA AAATTGCCTG CATGATATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_076407.1
CDS	323..1252
Translation	MFSPADNIFIILITGEFILGILGNGYIALVNWIDWIKKKKISTVDYILTNLVIARICLISVMVVNGIVIVLNPDVYTKNKQQIVIFTFWTFANYLNMWITTCLNVFYFLKIASSSHPLFLWLKWKIDMVVHWILLGCFAISLLVSLIAAIVLSCDYRFHAIAKHKRNITEMFHVSKIPYFEPLTLFNLFAIVPFIVSLISFFLLVRSLWRHTKQIKLYATGSRDPSTEVHVRAIKTMTSFIFFFFLYYISSILMTFSYLMTKYKLAVEFGEIAAILYPLGHSLILIVLNNKLRQTFVRMLTCRKIACMI

Target ORF information:

RefSeq Version	NM_023918.2
Organism	Homo sapiens(human)
Definition	Homo sapiens taste 2 receptor member 8 (TAS2R8), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_023918.2

ORF Insert Sequence:

ATGTTCAGTC CTGCAGATAA CATCTTTATA ATCCTAATAA CTGGAGAATT CATACTAGGA 
ATATTGGGGA ATGGATACAT TGCACTAGTC AACTGGATTG ACTGGATTAA GAAGAAAAAG 
ATTTCCACAG TTGACTACAT CCTTACCAAT TTAGTTATCG CCAGAATTTG TTTGATCAGT 
GTAATGGTTG TAAATGGCAT TGTAATAGTA CTGAACCCAG ATGTTTATAC AAAAAATAAA 
CAACAGATAG TCATTTTTAC CTTCTGGACA TTTGCCAACT ACTTAAATAT GTGGATTACC 
ACCTGCCTTA ATGTCTTCTA TTTTCTGAAG ATAGCCAGTT CCTCTCATCC ACTTTTTCTC 
TGGCTGAAGT GGAAAATTGA TATGGTGGTG CACTGGATCC TGCTGGGATG CTTTGCCATT 
TCCTTGTTGG TCAGCCTTAT AGCAGCAATA GTACTGAGTT GTGATTATAG GTTTCATGCA 
ATTGCCAAAC ATAAAAGAAA CATTACTGAA ATGTTCCATG TGAGTAAAAT ACCATACTTT 
GAACCCTTGA CTCTCTTTAA CCTGTTTGCA ATTGTCCCAT TTATTGTGTC ACTGATATCA 
TTTTTCCTTT TAGTAAGATC TTTATGGAGA CATACCAAGC AAATAAAACT CTATGCTACC 
GGCAGTAGAG ACCCCAGCAC AGAAGTTCAT GTGAGAGCCA TTAAAACTAT GACTTCATTT 
ATCTTCTTTT TTTTCCTATA CTATATTTCT TCTATTTTGA TGACCTTTAG CTATCTTATG 
ACAAAATACA AGTTAGCTGT GGAGTTTGGA GAGATTGCAG CAATTCTCTA CCCCTTGGGT 
CACTCACTTA TTTTAATTGT TTTAAATAAT AAACTGAGGC AGACATTTGT CAGAATGCTG 
ACATGTAGAA AAATTGCCTG CATGATATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Anti-cancer stemness and anti-invasive activity of bitter taste receptors, TAS2R8 and TAS2R10, in human neuroblastoma cells.
PloS one12(5)e0176851(2017)
Seo Y,Kim YS,Lee KE,Park TH,Kim Y

Human bitter taste receptors hTAS2R8 and hTAS2R39 with differential functions to recognize bitter peptides.
Bioscience, biotechnology, and biochemistry75(6)1188-90(2011)
Ueno Y,Sakurai T,Okada S,Abe K,Misaka T

The molecular receptive ranges of human TAS2R bitter taste receptors.
Chemical senses35(2)157-70(2010 Feb)
Meyerhof W,Batram C,Kuhn C,Brockhoff A,Chudoba E,Bufe B,Appendino G,Behrens M

Lineage-specific loss of function of bitter taste receptor genes in humans and nonhuman primates.
Genetics170(1)313-26(2005 May)
Go Y,Satta Y,Takenaka O,Takahata N

Evolution of bitter taste receptors in humans and apes.
Molecular biology and evolution22(3)432-6(2005 Mar)
Fischer A,Gilad Y,Man O,P??bo S

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TAS2R8 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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