TAS2R16 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	TAS2R16
Entrez Gene ID	50833
Full Name	taste 2 receptor member 16
Synonyms	T2R16
General protein information	Preferred Names taste 2 receptor member 16 Names taste receptor type 2 member 16 candidate taste receptor T2R16 taste receptor, type 2, member 16
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 7 Map Location: 7q31.32\|7q31
Summary	This gene encodes a member of a family of candidate taste receptors that are members of the G protein-coupled receptor superfamily. These family members are specifically expressed by taste receptor cells of the tongue and palate epithelia. Each of these apparently intronless genes encodes a 7-transmembrane receptor protein, functioning as a bitter taste receptor. This gene is clustered with another 3 candidate taste receptor genes in chromosome 7 and is genetically linked to loci that influence bitter perception. [provided by RefSeq, Jul 2008].
Disorder MIM:	604867
Disorder Html:	[Beta-glycopyranoside tasting] (3); {Alcohol dependence, susceptibility to}, 103780 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_016945.3	NP_058641.1	taste receptor type 2 member 16
NM_016945.2	NP_058641.1	taste receptor type 2 member 16

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	TAS2R16	NP_001009160.1
	TAS2R16	NP_001074228.1
Bos taurus (cattle)	TAS2R16	NP_001040093.1
Homo sapiens (human)	TAS2R16	NP_058641.1
Mus musculus (house mouse)	Tas2r118	NP_996905.1
Rattus norvegicus (Norway rat)	Tas2r118	NP_076484.1

Gene Ontology
Bibliography

Related articles in PubMed

Association between polymorphisms of TAS2R16 and susceptibility to colorectal cancer.
Barontini J, Antinucci M, Tofanelli S, Cammalleri M, Dal Monte M, Gemignani F, Vodicka P, Marangoni R, Vodickova L, Kupcinskas J, Vymetalkova V, Forsti A, Canzian F, Stein A, Moreno V, Mastrodonato N, Tavano F, Panza A, Barale R, Landi S, Campa D
BMC gastroenterology17(1)104(2017 Sep)

A bio-cultural approach to the study of food choice: The contribution of taste genetics, population and culture.
Risso DS, Giuliani C, Antinucci M, Morini G, Garagnani P, Tofanelli S, Luiselli D
Appetite114240-247(2017 Jul)

Principal component analysis of binding energies for single-point mutants of hT2R16 bound to an agonist correlate with experimental mutant cell response.
Chen DE, Willick DL, Ruckel JB, Floriano WB
Journal of computational biology : a journal of computational molecular cell biology22(1)37-53(2015 Jan)

Limited evidence for adaptive evolution and functional effect of allelic variation at rs702424 in the promoter of the TAS2R16 bitter taste receptor gene in Africa.
Campbell MC, Ranciaro A, Zinshteyn D, Rawlings-Goss R, Hirbo J, Thompson S, Woldemeskel D, Froment A, Omar SA, Bodo JM, Nyambo T, Belay G, Drayna D, Breslin PA, Tishkoff SA
Journal of human genetics59(6)349-52(2014 Jun)

Origin and differential selection of allelic variation at TAS2R16 associated with salicin bitter taste sensitivity in Africa.
Campbell MC, Ranciaro A, Zinshteyn D, Rawlings-Goss R, Hirbo J, Thompson S, Woldemeskel D, Froment A, Rucker JB, Omar SA, Bodo JM, Nyambo T, Belay G, Drayna D, Breslin PA, Tishkoff SA
Molecular biology and evolution31(2)288-302(2014 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Principal component analysis of binding energies for single-point mutants of hT2R16 bound to an agonist correlate with experimental mutant cell response.
Title: Principal component analysis of binding energies for single-point mutants of hT2R16 bound to an agonist correlate with experimental mutant cell response.

No significant association between rs702424 alleles and salicin bitter taste recognition, implying that this site does not contribute to salicin phenotypic variance.
Title: Limited evidence for adaptive evolution and functional effect of allelic variation at rs702424 in the promoter of the TAS2R16 bitter taste receptor gene in Africa.

Results showed that individuals with at least one derived T-allele at polymorphic site 516 have a higher sensitivity to salicin bitterness compared with individuals homozygous for the ancestral G-allele.
Title: Origin and differential selection of allelic variation at TAS2R16 associated with salicin bitter taste sensitivity in Africa.

Bitter taste receptor polymorphisms in TAS2R16 may be associated with human aging
Title: Bitter taste receptor polymorphisms and human aging.

The authors discuss the association between the TAS2R16 gene and the evolution of bitter taste receptors in different populations.
Title: Selection on the human bitter taste gene, TAS2R16, in Eurasian populations.

The following TAS2R16 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TAS2R16 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu19392	NM_016945.3 Latest version!	Homo sapiens taste 2 receptor member 16 (TAS2R16), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$154.50-$216.30 $309.00
View Old Accession Versions >>
OHu19392	NM_016945.2	Homo sapiens taste 2 receptor member 16 (TAS2R16), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$154.50-$216.30 $309.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

TAS2R16 ( NM_016945.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_058641.1 Homo sapiens taste 2 receptor member 16 (TAS2R16), mRNA.

Price & Availability↑

CloneID	OHu19392
Clone ID Related Accession (Same CDS sequence)	NM_016945.3 , NM_016945.2
Accession Version	NM_016945.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 876bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-21
Organism	Homo sapiens(human)
Product	taste receptor type 2 member 16
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC095524.1 and AC004838.2. This sequence is a reference standard in the RefSeqGene project. On May 17, 2019 this sequence version replaced NM_016945.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: BC095524.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000249284.3/ ENSP00000249284.2 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##

ATGATACCCA TCCAACTCAC TGTCTTCTTC ATGATCATCT ATGTGCTTGA GTCCTTGACA 
ATTATTGTGC AGAGCAGCCT AATTGTTGCA GTGCTGGGCA GAGAATGGCT GCAAGTCAGA 
AGGCTGATGC CTGTGGACAT GATTCTCATC AGCCTGGGCA TCTCTCGCTT CTGTCTACAG 
TGGGCATCAA TGCTGAACAA TTTTTGCTCC TATTTTAATT TGAATTATGT ACTTTGCAAC 
TTAACAATCA CCTGGGAATT TTTTAATATC CTTACATTCT GGTTAAACAG CTTGCTTACC 
GTGTTCTACT GCATCAAGGT CTCTTCTTTC ACCCATCACA TCTTTCTCTG GCTGAGGTGG 
AGAATTTTGA GGTTGTTTCC CTGGATATTA CTGGGTTCTC TGATGATTAC TTGTGTAACA 
ATCATCCCTT CAGCTATTGG GAATTACATT CAAATTCAGT TACTCACCAT GGAGCATCTA 
CCAAGAAACA GCACTGTAAC TGACAAACTT GAAAATTTTC ATCAGTATCA GTTCCAGGCT 
CATACAGTTG CATTGGTTAT TCCTTTCATC CTGTTCCTGG CCTCCACCAT CTTTCTCATG 
GCATCACTGA CCAAGCAGAT ACAACATCAT AGCACTGGTC ACTGCAATCC AAGCATGAAA 
GCGCGCTTCA CTGCCCTGAG GTCCCTTGCC GTCTTATTTA TTGTGTTTAC CTCTTACTTT 
CTAACCATAC TCATCACCAT TATAGGTACT CTATTTGATA AGAGATGTTG GTTATGGGTC 
TGGGAAGCTT TTGTCTATGC TTTCATCTTA ATGCATTCCA CTTCACTGAT GCTGAGCAGC 
CCTACGTTGA AAAGGATTCT AAAGGGAAAG TGCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_058641.1
CDS	67..942
Translation	MIPIQLTVFFMIIYVLESLTIIVQSSLIVAVLGREWLQVRRLMPVDMILISLGISRFCLQWASMLNNFCSYFNLNYVLCNLTITWEFFNILTFWLNSLLTVFYCIKVSSFTHHIFLWLRWRILRLFPWILLGSLMITCVTIIPSAIGNYIQIQLLTMEHLPRNSTVTDKLENFHQYQFQAHTVALVIPFILFLASTIFLMASLTKQIQHHSTGHCNPSMKARFTALRSLAVLFIVFTSYFLTILITIIGTLFDKRCWLWVWEAFVYAFILMHSTSLMLSSPTLKRILKGKC

Target ORF information:

RefSeq Version	NM_016945.3
Organism	Homo sapiens(human)
Definition	Homo sapiens taste 2 receptor member 16 (TAS2R16), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_016945.3

ORF Insert Sequence:

ATGATACCCA TCCAACTCAC TGTCTTCTTC ATGATCATCT ATGTGCTTGA GTCCTTGACA 
ATTATTGTGC AGAGCAGCCT AATTGTTGCA GTGCTGGGCA GAGAATGGCT GCAAGTCAGA 
AGGCTGATGC CTGTGGACAT GATTCTCATC AGCCTGGGCA TCTCTCGCTT CTGTCTACAG 
TGGGCATCAA TGCTGAACAA TTTTTGCTCC TATTTTAATT TGAATTATGT ACTTTGCAAC 
TTAACAATCA CCTGGGAATT TTTTAATATC CTTACATTCT GGTTAAACAG CTTGCTTACC 
GTGTTCTACT GCATCAAGGT CTCTTCTTTC ACCCATCACA TCTTTCTCTG GCTGAGGTGG 
AGAATTTTGA GGTTGTTTCC CTGGATATTA CTGGGTTCTC TGATGATTAC TTGTGTAACA 
ATCATCCCTT CAGCTATTGG GAATTACATT CAAATTCAGT TACTCACCAT GGAGCATCTA 
CCAAGAAACA GCACTGTAAC TGACAAACTT GAAAATTTTC ATCAGTATCA GTTCCAGGCT 
CATACAGTTG CATTGGTTAT TCCTTTCATC CTGTTCCTGG CCTCCACCAT CTTTCTCATG 
GCATCACTGA CCAAGCAGAT ACAACATCAT AGCACTGGTC ACTGCAATCC AAGCATGAAA 
GCGCGCTTCA CTGCCCTGAG GTCCCTTGCC GTCTTATTTA TTGTGTTTAC CTCTTACTTT 
CTAACCATAC TCATCACCAT TATAGGTACT CTATTTGATA AGAGATGTTG GTTATGGGTC 
TGGGAAGCTT TTGTCTATGC TTTCATCTTA ATGCATTCCA CTTCACTGAT GCTGAGCAGC 
CCTACGTTGA AAAGGATTCT AAAGGGAAAG TGCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TAS2R16 ( NM_016945.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_058641.1 Homo sapiens taste 2 receptor member 16 (TAS2R16), mRNA.

Price & Availability↑

CloneID	OHu19392
Clone ID Related Accession (Same CDS sequence)	NM_016945.3 , NM_016945.2
Accession Version	NM_016945.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 876bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-16
Organism	Homo sapiens(human)
Product	taste receptor type 2 member 16
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC095524.1 and AC004838.2. This sequence is a reference standard in the RefSeqGene project. On Jun 23, 2005 this sequence version replaced NM_016945.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: BC095524.1 [ECO:0000345] ##Evidence-Data-END##

ATGATACCCA TCCAACTCAC TGTCTTCTTC ATGATCATCT ATGTGCTTGA GTCCTTGACA 
ATTATTGTGC AGAGCAGCCT AATTGTTGCA GTGCTGGGCA GAGAATGGCT GCAAGTCAGA 
AGGCTGATGC CTGTGGACAT GATTCTCATC AGCCTGGGCA TCTCTCGCTT CTGTCTACAG 
TGGGCATCAA TGCTGAACAA TTTTTGCTCC TATTTTAATT TGAATTATGT ACTTTGCAAC 
TTAACAATCA CCTGGGAATT TTTTAATATC CTTACATTCT GGTTAAACAG CTTGCTTACC 
GTGTTCTACT GCATCAAGGT CTCTTCTTTC ACCCATCACA TCTTTCTCTG GCTGAGGTGG 
AGAATTTTGA GGTTGTTTCC CTGGATATTA CTGGGTTCTC TGATGATTAC TTGTGTAACA 
ATCATCCCTT CAGCTATTGG GAATTACATT CAAATTCAGT TACTCACCAT GGAGCATCTA 
CCAAGAAACA GCACTGTAAC TGACAAACTT GAAAATTTTC ATCAGTATCA GTTCCAGGCT 
CATACAGTTG CATTGGTTAT TCCTTTCATC CTGTTCCTGG CCTCCACCAT CTTTCTCATG 
GCATCACTGA CCAAGCAGAT ACAACATCAT AGCACTGGTC ACTGCAATCC AAGCATGAAA 
GCGCGCTTCA CTGCCCTGAG GTCCCTTGCC GTCTTATTTA TTGTGTTTAC CTCTTACTTT 
CTAACCATAC TCATCACCAT TATAGGTACT CTATTTGATA AGAGATGTTG GTTATGGGTC 
TGGGAAGCTT TTGTCTATGC TTTCATCTTA ATGCATTCCA CTTCACTGAT GCTGAGCAGC 
CCTACGTTGA AAAGGATTCT AAAGGGAAAG TGCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_058641.1
CDS	67..942
Translation	MIPIQLTVFFMIIYVLESLTIIVQSSLIVAVLGREWLQVRRLMPVDMILISLGISRFCLQWASMLNNFCSYFNLNYVLCNLTITWEFFNILTFWLNSLLTVFYCIKVSSFTHHIFLWLRWRILRLFPWILLGSLMITCVTIIPSAIGNYIQIQLLTMEHLPRNSTVTDKLENFHQYQFQAHTVALVIPFILFLASTIFLMASLTKQIQHHSTGHCNPSMKARFTALRSLAVLFIVFTSYFLTILITIIGTLFDKRCWLWVWEAFVYAFILMHSTSLMLSSPTLKRILKGKC

Target ORF information:

RefSeq Version	NM_016945.2
Organism	Homo sapiens(human)
Definition	Homo sapiens taste 2 receptor member 16 (TAS2R16), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_016945.2

ORF Insert Sequence:

ATGATACCCA TCCAACTCAC TGTCTTCTTC ATGATCATCT ATGTGCTTGA GTCCTTGACA 
ATTATTGTGC AGAGCAGCCT AATTGTTGCA GTGCTGGGCA GAGAATGGCT GCAAGTCAGA 
AGGCTGATGC CTGTGGACAT GATTCTCATC AGCCTGGGCA TCTCTCGCTT CTGTCTACAG 
TGGGCATCAA TGCTGAACAA TTTTTGCTCC TATTTTAATT TGAATTATGT ACTTTGCAAC 
TTAACAATCA CCTGGGAATT TTTTAATATC CTTACATTCT GGTTAAACAG CTTGCTTACC 
GTGTTCTACT GCATCAAGGT CTCTTCTTTC ACCCATCACA TCTTTCTCTG GCTGAGGTGG 
AGAATTTTGA GGTTGTTTCC CTGGATATTA CTGGGTTCTC TGATGATTAC TTGTGTAACA 
ATCATCCCTT CAGCTATTGG GAATTACATT CAAATTCAGT TACTCACCAT GGAGCATCTA 
CCAAGAAACA GCACTGTAAC TGACAAACTT GAAAATTTTC ATCAGTATCA GTTCCAGGCT 
CATACAGTTG CATTGGTTAT TCCTTTCATC CTGTTCCTGG CCTCCACCAT CTTTCTCATG 
GCATCACTGA CCAAGCAGAT ACAACATCAT AGCACTGGTC ACTGCAATCC AAGCATGAAA 
GCGCGCTTCA CTGCCCTGAG GTCCCTTGCC GTCTTATTTA TTGTGTTTAC CTCTTACTTT 
CTAACCATAC TCATCACCAT TATAGGTACT CTATTTGATA AGAGATGTTG GTTATGGGTC 
TGGGAAGCTT TTGTCTATGC TTTCATCTTA ATGCATTCCA CTTCACTGAT GCTGAGCAGC 
CCTACGTTGA AAAGGATTCT AAAGGGAAAG TGCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Association between polymorphisms of TAS2R16 and susceptibility to colorectal cancer.
BMC gastroenterology17(1)104(2017 Sep)
Barontini J,Antinucci M,Tofanelli S,Cammalleri M,Dal Monte M,Gemignani F,Vodicka P,Marangoni R,Vodickova L,Kupcinskas J,Vymetalkova V,Forsti A,Canzian F,Stein A,Moreno V,Mastrodonato N,Tavano F,Panza A,Barale R,Landi S,Campa D

A bio-cultural approach to the study of food choice: The contribution of taste genetics, population and culture.
Appetite114240-247(2017 Jul)
Risso DS,Giuliani C,Antinucci M,Morini G,Garagnani P,Tofanelli S,Luiselli D

Principal component analysis of binding energies for single-point mutants of hT2R16 bound to an agonist correlate with experimental mutant cell response.
Journal of computational biology : a journal of computational molecular cell biology22(1)37-53(2015 Jan)
Chen DE,Willick DL,Ruckel JB,Floriano WB

Limited evidence for adaptive evolution and functional effect of allelic variation at rs702424 in the promoter of the TAS2R16 bitter taste receptor gene in Africa.
Journal of human genetics59(6)349-52(2014 Jun)
Campbell MC,Ranciaro A,Zinshteyn D,Rawlings-Goss R,Hirbo J,Thompson S,Woldemeskel D,Froment A,Omar SA,Bodo JM,Nyambo T,Belay G,Drayna D,Breslin PA,Tishkoff SA

Origin and differential selection of allelic variation at TAS2R16 associated with salicin bitter taste sensitivity in Africa.
Molecular biology and evolution31(2)288-302(2014 Feb)
Campbell MC,Ranciaro A,Zinshteyn D,Rawlings-Goss R,Hirbo J,Thompson S,Woldemeskel D,Froment A,Rucker JB,Omar SA,Bodo JM,Nyambo T,Belay G,Drayna D,Breslin PA,Tishkoff SA

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TAS2R16 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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