PAX9 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	PAX9
Entrez Gene ID	5083
Full Name	paired box 9
Synonyms	STHAG3
General protein information	Preferred Names paired box 9 Names paired box protein Pax-9 paired domain gene 9
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 14 Map Location: 14q13.3
Summary	This gene is a member of the paired box (PAX) family of transcription factors. Members of this gene family typically contain a paired box domain, an octapeptide, and a paired-type homeodomain. These genes play critical roles during fetal development and cancer growth. Mice lacking this gene exhibit impaired development of organs, musculature and the skeleton, including absent and abnormally developed teeth, and neonatal lethality. Mutations in the human gene are associated with selective tooth agenesis-3. [provided by RefSeq, Sep 2015].
Disorder MIM:	167416
Disorder Html:	Tooth agenesis, selective, 3, 604625 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001372076.1	NP_001359005.1	paired box protein Pax-9
NM_006194.3	NP_006185.1	paired box protein Pax-9

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	PAX9	XP_001143345.2
Canis lupus familiaris (dog)	PAX9	XP_005623393.1
	PAX9	XP_002805071.1
Bos taurus (cattle)	PAX9	NP_001179298.1
Homo sapiens (human)	PAX9	NP_006185.1
Mus musculus (house mouse)	Pax9	NP_035171.1
Gallus gallus (chicken)	PAX9	XP_004941978.1
Xenopus tropicalis (tropical clawed frog)	pax9	XP_002935394.1
Rattus norvegicus (Norway rat)	Pax9	NP_001034628.1
Danio rerio (zebrafish)	pax9	NP_571373.1

Gene Ontology
Bibliography

Related articles in PubMed

PAX9 regulates squamous cell differentiation and carcinogenesis in the oro-oesophageal epithelium.
Xiong Z, Ren S, Chen H, Liu Y, Huang C, Zhang YL, Odera JO, Chen T, Kist R, Peters H, Garman K, Sun Z, Chen X
The Journal of pathology244(2)164-175(2018 Feb)

Nine Novel PAX9 Mutations and a Distinct Tooth Agenesis Genotype-Phenotype.
Wong SW, Han D, Zhang H, Liu Y, Zhang X, Miao MZ, Wang Y, Zhao N, Zeng L, Bai B, Wang YX, Liu H, Frazier-Bowers SA, Feng H
Journal of dental research97(2)155-162(2018 Feb)

A novel G to A transition at initiation codon and exon-intron boundary of PAX9 identified in association with familial isolated oligodontia.
Sarkar T, Bansal R, Das P
Gene63569-76(2017 Nov)

Genome-wide DNA methylation profiling integrated with gene expression profiling identifies
Rani L, Mathur N, Gupta R, Gogia A, Kaur G, Dhanjal JK, Sundar D, Kumar L, Sharma A
Clinical epigenetics957(2017)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

in vitro functional analysis creating PAX9 minigene construct did apparently show no effect on the splice-site migration. It is therefore proposed that haploinsufficiency of PAX9 is the causal factor for tooth agenesis in this family.
Title: A novel G to A transition at initiation codon and exon-intron boundary of PAX9 identified in association with familial isolated oligodontia.

Statistically significant relations were found between detected 22 variations in PAX9 gene and tooth size and were detected in which 18 of them are novel.
Title: Effects of PAX9 and MSX1 gene variants to hypodontia, tooth size and the type of congenitally missing teeth.

The AG and GG genotypes at rs2073244 and the CC genotype at rs4904210 may strengthen the association between cytomegalovirus infection and low birth weight.
Title: Interaction between HCMV infection and PAX9 gene polymorphisms in low birth weight infants.

results demonstrate a new initiation codon mutation in the PAX9 gene; this mutation probably caused the oligodontia in the investigated Chinese family through haplo-insufficiency
Title: A novel initiation codon mutation of PAX9 in a family with oligodontia.

A direct effect of rs12882923 and rs12883049 polymorphisms on the dental agenesis was excluded.
Title: Novel PAX9 gene polymorphisms and mutations and susceptibility to tooth agenesis in the Czech population.

The following PAX9 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PAX9 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu22291	NM_001372076.1 Latest version!	Homo sapiens paired box 9 (PAX9), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu22291	NM_006194.3 Latest version!	Homo sapiens paired box 9 (PAX9), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

PAX9 ( NM_001372076.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001359005.1 Homo sapiens paired box 9 (PAX9), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu22291
Clone ID Related Accession (Same CDS sequence)	NM_001372076.1 , NM_006194.3
Accession Version	NM_001372076.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1026bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-04
Organism	Homo sapiens(human)
Product	paired box protein Pax-9
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL079303.3. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR7346977.1755623.1, SRR1660803.20274.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on manual assertion, conservation, expression, longest protein ##RefSeq-Attributes-END##

ATGGAGCCAG CCTTCGGGGA GGTGAACCAG CTGGGAGGAG TGTTCGTGAA CGGGAGGCCG 
CTGCCCAACG CCATCCGGCT TCGCATCGTG GAACTGGCCC AACTGGGCAT CCGACCGTGT 
GACATCAGCC GCCAGCTACG GGTCTCGCAC GGCTGCGTCA GCAAGATCCT GGCGCGATAC 
AACGAGACGG GCTCGATCTT GCCAGGAGCC ATCGGGGGCA GCAAGCCCCG GGTCACTACC 
CCCACCGTGG TGAAACACAT CCGGACCTAC AAGCAGAGAG ACCCCGGCAT CTTCGCCTGG 
GAGATCCGGG ACCGCCTGCT GGCGGACGGC GTGTGCGACA AGTACAATGT GCCCTCCGTG 
AGCTCCATCA GCCGCATTCT GCGCAACAAG ATCGGCAACT TGGCCCAGCA GGGTCATTAC 
GACTCATACA AGCAGCACCA GCCGACGCCG CAGCCAGCGC TGCCCTACAA CCACATCTAC 
TCGTACCCCA GCCCTATCAC GGCGGCGGCC GCCAAGGTGC CCACGCCACC CGGGGTGCCT 
GCCATCCCCG GTTCGGTGGC CATGCCGCGC ACCTGGCCCT CCTCGCACTC CGTCACCGAC 
ATCCTGGGCA TCCGCTCCAT CACCGACCAA GTGAGCGACA GCTCCCCCTA CCACAGCCCC 
AAGGTGGAGG AGTGGAGCAG CCTGGGCCGC AACAACTTCC CCGCCGCCGC CCCGCACGCG 
GTGAACGGGT TGGAGAAGGG AGCCCTGGAG CAGGAAGCCA AGTACGGTCA GGCACCAAAT 
GGTCTCCCAG CTGTGGGCAG TTTTGTGTCA GCATCCAGCA TGGCTCCTTA CCCTACCCCA 
GCCCAAGTGT CGCCTTACAT GACCTACAGT GCTGCTCCTT CTGGTTATGT TGCTGGACAT 
GGGTGGCAAC ATGCTGGGGG CACCTCATTG TCTCCCCACA ACTGTGACAT TCCGGCATCG 
CTGGCGTTCA AGGGAATGCA GGCAGCCAGA GAAGGTAGTC ATTCTGTCAC GGCTTCCGCG 
CTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001359005.1
CDS	231..1256
Translation	MEPAFGEVNQLGGVFVNGRPLPNAIRLRIVELAQLGIRPCDISRQLRVSHGCVSKILARYNETGSILPGAIGGSKPRVTTPTVVKHIRTYKQRDPGIFAWEIRDRLLADGVCDKYNVPSVSSISRILRNKIGNLAQQGHYDSYKQHQPTPQPALPYNHIYSYPSPITAAAAKVPTPPGVPAIPGSVAMPRTWPSSHSVTDILGIRSITDQVSDSSPYHSPKVEEWSSLGRNNFPAAAPHAVNGLEKGALEQEAKYGQAPNGLPAVGSFVSASSMAPYPTPAQVSPYMTYSAAPSGYVAGHGWQHAGGTSLSPHNCDIPASLAFKGMQAAREGSHSVTASAL

Target ORF information:

RefSeq Version	NM_001372076.1
Organism	Homo sapiens(human)
Definition	Homo sapiens paired box 9 (PAX9), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001372076.1

ORF Insert Sequence:

ATGGAGCCAG CCTTCGGGGA GGTGAACCAG CTGGGAGGAG TGTTCGTGAA CGGGAGGCCG 
CTGCCCAACG CCATCCGGCT TCGCATCGTG GAACTGGCCC AACTGGGCAT CCGACCGTGT 
GACATCAGCC GCCAGCTACG GGTCTCGCAC GGCTGCGTCA GCAAGATCCT GGCGCGATAC 
AACGAGACGG GCTCGATCTT GCCAGGAGCC ATCGGGGGCA GCAAGCCCCG GGTCACTACC 
CCCACCGTGG TGAAACACAT CCGGACCTAC AAGCAGAGAG ACCCCGGCAT CTTCGCCTGG 
GAGATCCGGG ACCGCCTGCT GGCGGACGGC GTGTGCGACA AGTACAATGT GCCCTCCGTG 
AGCTCCATCA GCCGCATTCT GCGCAACAAG ATCGGCAACT TGGCCCAGCA GGGTCATTAC 
GACTCATACA AGCAGCACCA GCCGACGCCG CAGCCAGCGC TGCCCTACAA CCACATCTAC 
TCGTACCCCA GCCCTATCAC GGCGGCGGCC GCCAAGGTGC CCACGCCACC CGGGGTGCCT 
GCCATCCCCG GTTCGGTGGC CATGCCGCGC ACCTGGCCCT CCTCGCACTC CGTCACCGAC 
ATCCTGGGCA TCCGCTCCAT CACCGACCAA GTGAGCGACA GCTCCCCCTA CCACAGCCCC 
AAGGTGGAGG AGTGGAGCAG CCTGGGCCGC AACAACTTCC CCGCCGCCGC CCCGCACGCG 
GTGAACGGGT TGGAGAAGGG AGCCCTGGAG CAGGAAGCCA AGTACGGTCA GGCACCAAAT 
GGTCTCCCAG CTGTGGGCAG TTTTGTGTCA GCATCCAGCA TGGCTCCTTA CCCTACCCCA 
GCCCAAGTGT CGCCTTACAT GACCTACAGT GCTGCTCCTT CTGGTTATGT TGCTGGACAT 
GGGTGGCAAC ATGCTGGGGG CACCTCATTG TCTCCCCACA ACTGTGACAT TCCGGCATCG 
CTGGCGTTCA AGGGAATGCA GGCAGCCAGA GAAGGTAGTC ATTCTGTCAC GGCTTCCGCG 
CTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PAX9 ( NM_006194.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_006185.1 Homo sapiens paired box 9 (PAX9), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu22291
Clone ID Related Accession (Same CDS sequence)	NM_001372076.1 , NM_006194.3
Accession Version	NM_006194.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1026bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-01
Organism	Homo sapiens(human)
Product	paired box protein Pax-9
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB233208.1, DB196800.1, BC001159.1, AL079303.3 and AB248958.1. This sequence is a reference standard in the RefSeqGene project. On or before Aug 31, 2013 this sequence version replaced XM_005267715.1, NM_006194.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## CDS exon combination :: AB248958.1, SRR1660803.20274.1 [ECO:0000331] RNAseq introns :: single sample supports all introns SAMEA1968832, SAMEA2145240 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAGCCAG CCTTCGGGGA GGTGAACCAG CTGGGAGGAG TGTTCGTGAA CGGGAGGCCG 
CTGCCCAACG CCATCCGGCT TCGCATCGTG GAACTGGCCC AACTGGGCAT CCGACCGTGT 
GACATCAGCC GCCAGCTACG GGTCTCGCAC GGCTGCGTCA GCAAGATCCT GGCGCGATAC 
AACGAGACGG GCTCGATCTT GCCAGGAGCC ATCGGGGGCA GCAAGCCCCG GGTCACTACC 
CCCACCGTGG TGAAACACAT CCGGACCTAC AAGCAGAGAG ACCCCGGCAT CTTCGCCTGG 
GAGATCCGGG ACCGCCTGCT GGCGGACGGC GTGTGCGACA AGTACAATGT GCCCTCCGTG 
AGCTCCATCA GCCGCATTCT GCGCAACAAG ATCGGCAACT TGGCCCAGCA GGGTCATTAC 
GACTCATACA AGCAGCACCA GCCGACGCCG CAGCCAGCGC TGCCCTACAA CCACATCTAC 
TCGTACCCCA GCCCTATCAC GGCGGCGGCC GCCAAGGTGC CCACGCCACC CGGGGTGCCT 
GCCATCCCCG GTTCGGTGGC CATGCCGCGC ACCTGGCCCT CCTCGCACTC CGTCACCGAC 
ATCCTGGGCA TCCGCTCCAT CACCGACCAA GTGAGCGACA GCTCCCCCTA CCACAGCCCC 
AAGGTGGAGG AGTGGAGCAG CCTGGGCCGC AACAACTTCC CCGCCGCCGC CCCGCACGCG 
GTGAACGGGT TGGAGAAGGG AGCCCTGGAG CAGGAAGCCA AGTACGGTCA GGCACCAAAT 
GGTCTCCCAG CTGTGGGCAG TTTTGTGTCA GCATCCAGCA TGGCTCCTTA CCCTACCCCA 
GCCCAAGTGT CGCCTTACAT GACCTACAGT GCTGCTCCTT CTGGTTATGT TGCTGGACAT 
GGGTGGCAAC ATGCTGGGGG CACCTCATTG TCTCCCCACA ACTGTGACAT TCCGGCATCG 
CTGGCGTTCA AGGGAATGCA GGCAGCCAGA GAAGGTAGTC ATTCTGTCAC GGCTTCCGCG 
CTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006185.1
CDS	727..1752
Translation	MEPAFGEVNQLGGVFVNGRPLPNAIRLRIVELAQLGIRPCDISRQLRVSHGCVSKILARYNETGSILPGAIGGSKPRVTTPTVVKHIRTYKQRDPGIFAWEIRDRLLADGVCDKYNVPSVSSISRILRNKIGNLAQQGHYDSYKQHQPTPQPALPYNHIYSYPSPITAAAAKVPTPPGVPAIPGSVAMPRTWPSSHSVTDILGIRSITDQVSDSSPYHSPKVEEWSSLGRNNFPAAAPHAVNGLEKGALEQEAKYGQAPNGLPAVGSFVSASSMAPYPTPAQVSPYMTYSAAPSGYVAGHGWQHAGGTSLSPHNCDIPASLAFKGMQAAREGSHSVTASAL

Target ORF information:

RefSeq Version	NM_006194.3
Organism	Homo sapiens(human)
Definition	Homo sapiens paired box 9 (PAX9), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006194.3

ORF Insert Sequence:

ATGGAGCCAG CCTTCGGGGA GGTGAACCAG CTGGGAGGAG TGTTCGTGAA CGGGAGGCCG 
CTGCCCAACG CCATCCGGCT TCGCATCGTG GAACTGGCCC AACTGGGCAT CCGACCGTGT 
GACATCAGCC GCCAGCTACG GGTCTCGCAC GGCTGCGTCA GCAAGATCCT GGCGCGATAC 
AACGAGACGG GCTCGATCTT GCCAGGAGCC ATCGGGGGCA GCAAGCCCCG GGTCACTACC 
CCCACCGTGG TGAAACACAT CCGGACCTAC AAGCAGAGAG ACCCCGGCAT CTTCGCCTGG 
GAGATCCGGG ACCGCCTGCT GGCGGACGGC GTGTGCGACA AGTACAATGT GCCCTCCGTG 
AGCTCCATCA GCCGCATTCT GCGCAACAAG ATCGGCAACT TGGCCCAGCA GGGTCATTAC 
GACTCATACA AGCAGCACCA GCCGACGCCG CAGCCAGCGC TGCCCTACAA CCACATCTAC 
TCGTACCCCA GCCCTATCAC GGCGGCGGCC GCCAAGGTGC CCACGCCACC CGGGGTGCCT 
GCCATCCCCG GTTCGGTGGC CATGCCGCGC ACCTGGCCCT CCTCGCACTC CGTCACCGAC 
ATCCTGGGCA TCCGCTCCAT CACCGACCAA GTGAGCGACA GCTCCCCCTA CCACAGCCCC 
AAGGTGGAGG AGTGGAGCAG CCTGGGCCGC AACAACTTCC CCGCCGCCGC CCCGCACGCG 
GTGAACGGGT TGGAGAAGGG AGCCCTGGAG CAGGAAGCCA AGTACGGTCA GGCACCAAAT 
GGTCTCCCAG CTGTGGGCAG TTTTGTGTCA GCATCCAGCA TGGCTCCTTA CCCTACCCCA 
GCCCAAGTGT CGCCTTACAT GACCTACAGT GCTGCTCCTT CTGGTTATGT TGCTGGACAT 
GGGTGGCAAC ATGCTGGGGG CACCTCATTG TCTCCCCACA ACTGTGACAT TCCGGCATCG 
CTGGCGTTCA AGGGAATGCA GGCAGCCAGA GAAGGTAGTC ATTCTGTCAC GGCTTCCGCG 
CTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

PAX9 regulates squamous cell differentiation and carcinogenesis in the oro-oesophageal epithelium.
The Journal of pathology244(2)164-175(2018 Feb)
Xiong Z,Ren S,Chen H,Liu Y,Huang C,Zhang YL,Odera JO,Chen T,Kist R,Peters H,Garman K,Sun Z,Chen X

Nine Novel PAX9 Mutations and a Distinct Tooth Agenesis Genotype-Phenotype.
Journal of dental research97(2)155-162(2018 Feb)
Wong SW,Han D,Zhang H,Liu Y,Zhang X,Miao MZ,Wang Y,Zhao N,Zeng L,Bai B,Wang YX,Liu H,Frazier-Bowers SA,Feng H

A novel G to A transition at initiation codon and exon-intron boundary of PAX9 identified in association with familial isolated oligodontia.
Gene63569-76(2017 Nov)
Sarkar T,Bansal R,Das P

Genome-wide DNA methylation profiling integrated with gene expression profiling identifies
Clinical epigenetics957(2017)
Rani L,Mathur N,Gupta R,Gogia A,Kaur G,Dhanjal JK,Sundar D,Kumar L,Sharma A

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PAX9 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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