PDCL cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	PDCL
Entrez Gene ID	5082
Full Name	phosducin like
Synonyms	PhLP
General protein information	Preferred Names phosducin like Names phosducin-like protein
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 9 Map Location: 9q33.2
Summary	Phosducin-like protein is a putative modulator of heterotrimeric G proteins. The protein shares extensive amino acid sequence homology with phosducin, a phosphoprotein expressed in retina and pineal gland. Both phosducin-like protein and phosphoducin have been shown to regulate G-protein signaling by binding to the beta-gamma subunits of G proteins. [provided by RefSeq, Jul 2008].
Disorder MIM:	604421

mRNA and Protein(s)

mRNA	Protein	Name
NM_005388.5	NP_005379.3	phosducin-like protein
XM_017014785.1	XP_016870274.1	phosducin-like protein isoform X1
NM_005388.4	NP_005379.3	phosducin-like protein

Pathways from BioSystems

Homologies

Homo sapiens (human)	PDCL	NP_005379.3
Danio rerio (zebrafish)	pdcl	NP_955941.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP004468	XP_313766.4
Xenopus tropicalis (tropical clawed frog)	pdcl	NP_001016070.1
Rattus norvegicus (Norway rat)	Pdcl	NP_071583.1
	PDCL	XP_001086958.1
Mus musculus (house mouse)	Pdcl	NP_080452.2
Gallus gallus (chicken)	PDCL	XP_004946061.1
Bos taurus (cattle)	PDCL	NP_777184.2
Pan troglodytes (chimpanzee)	PDCL	XP_528422.1
Canis lupus familiaris (dog)	PDCL	XP_005625456.1
Drosophila melanogaster (fruit fly)	CG7650	NP_648786.1

Gene Ontology
Bibliography

Related articles in PubMed

Architecture of the human interactome defines protein communities and disease networks.
Huttlin EL, Bruckner RJ, Paulo JA, Cannon JR, Ting L, Baltier K, Colby G, Gebreab F, Gygi MP, Parzen H, Szpyt J, Tam S, Zarraga G, Pontano-Vaites L, Swarup S, White AE, Schweppe DK, Rad R, Erickson BK, Obar RA, Guruharsha KG, Li K, Artavanis-Tsakonas S, Gygi SP, Harper JW
Nature545(7655)505-509(2017 05)

Structures of the G?-CCT and PhLP1-G?-CCT complexes reveal a mechanism for G-protein ?-subunit folding and G?? dimer assembly.
Plimpton RL, Cu?llar J, Lai CW, Aoba T, Makaju A, Franklin S, Mathis AD, Prince JT, Carrascosa JL, Valpuesta JM, Willardson BM
Proceedings of the National Academy of Sciences of the United States of America112(8)2413-8(2015 Feb)

Programmed cell death protein 5 interacts with the cytosolic chaperonin containing tailless complex polypeptide 1 (CCT) to regulate ?-tubulin folding.
Tracy CM, Gray AJ, Cu?llar J, Shaw TS, Howlett AC, Taylor RM, Prince JT, Ahn NG, Valpuesta JM, Willardson BM
The Journal of biological chemistry289(7)4490-502(2014 Feb)

Splice isoforms of phosducin-like protein control the expression of heterotrimeric G proteins.
Gao X, Sinha S, Belcastro M, Woodard C, Ramamurthy V, Stoilov P, Sokolov M
The Journal of biological chemistry288(36)25760-8(2013 Sep)

Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
Comuzzie AG, Cole SA, Laston SL, Voruganti VS, Haack K, Gibbs RA, Butte NF
PloS one7(12)e51954(2012)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

PhLP1 binding stabilizes the Gbeta fold, disrupting interactions with CCT and releasing a PhLP1-Gbeta dimer for assembly with Ggamma.
Title: Structures of the G?-CCT and PhLP1-G?-CCT complexes reveal a mechanism for G-protein ?-subunit folding and G?? dimer assembly.

evidence of a generic mechanism, whereby the splicing of the PhLP gene could potentially and efficiently regulate the cellular levels of heterotrimeric G proteins.
Title: Splice isoforms of phosducin-like protein control the expression of heterotrimeric G proteins.

PhLP-M1-G149, a Gbetagamma-interacting construct derived from phosducin-like protein 1 (PhLP) is a differential inhibitor of Gbetagamma
Title: Differential inhibitor of Gbetagamma signaling to AKT and ERK derived from phosducin-like protein: effect on sphingosine 1-phosphate-induced endothelial cell migration and in vitro angiogenesis.

cytosolic chaperonin complex-dependent mechanism exists for Gbeta5-RGS7 assembly that utilizes the co-chaperone activity of PhLP1 in a unique way
Title: Role of molecular chaperones in G protein beta5/regulator of G protein signaling dimer assembly and G protein betagamma dimer specificity.

PhLP phosphorylation permits the release of a PhLP x Gbeta intermediate from cytosolic chaperonin complex, allowing Ggamma to associate with Gbeta in this intermediate complex.
Title: Mechanism of assembly of G protein betagamma subunits by protein kinase CK2-phosphorylated phosducin-like protein and the cytosolic chaperonin complex.

The following PDCL gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PDCL cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu12893	NM_005388.5 Latest version!	Homo sapiens phosducin like (PDCL), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$154.50-$216.30 $309.00
OHu98681	XM_017014785.1 Latest version!	Homo sapiens phosducin like (PDCL), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
View Old Accession Versions >>
OHu12893	NM_005388.4	Homo sapiens phosducin like (PDCL), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$154.50-$216.30 $309.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

PDCL ( NM_005388.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_005379.3 Homo sapiens phosducin like (PDCL), mRNA.

Price & Availability↑

CloneID	OHu12893
Clone ID Related Accession (Same CDS sequence)	NM_005388.5 , NM_005388.4
Accession Version	NM_005388.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 906bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-10
Organism	Homo sapiens(human)
Product	phosducin-like protein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK313429.1 and AL359512.15. On May 17, 2019 this sequence version replaced NM_005388.4. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660809.86814.1, SRR7410570.437364.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2467144, SAMEA2467146 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000259467.9/ ENSP00000259467.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGACCACCC TTGATGATAA GTTGCTGGGG GAGAAACTGC AGTACTACTA TAGCAGCAGT 
GAGGATGAGG ACAGTGACCA CGAGGACAAG GACCGAGGCA GATGTGCCCC AGCCAGCAGT 
TCTGTGCCTG CAGAGGCTGA GCTGGCAGGC GAAGGCATCT CAGTTAACAC AGGCCCAAAA 
GGTGTGATCA ATGACTGGCG CCGCTTCAAG CAGTTGGAGA CAGAGCAGAG GGAGGAGCAG 
TGCCGGGAGA TGGAAAGGCT GATCAAGAAG CTGTCAATGA CTTGCAGGTC CCATCTGGAT 
GAAGAGGAGG AGCAACAGAA ACAGAAAGAC CTCCAGGAGA AGATCAGTGG GAAGATGACT 
CTGAAGGAGT TTGCCATAAT GAATGAGGAC CAAGATGATG AAGAGTTTCT GCAGCAGTAC 
CGGAAGCAGC GAATGGAAGA GATGCGGCAG CAGCTTCACA AGGGGCCCCA ATTCAAGCAG 
GTTTTTGAGA TCTCCAGTGG AGAAGGGTTT TTAGACATGA TTGATAAAGA ACAGAAAAGC 
ATTGTCATCA TGGTTCATAT TTATGAGGAT GGCATTCCAG GGACCGAAGC CATGAATGGT 
TGCATGATCT GCCTTGCCGC AGAGTACCCA GCTGTCAAGT TCTGCAAGGT GAAGAGCTCA 
GTTATTGGCG CCAGCAGTCA GTTCACCAGG AATGCCCTTC CTGCCCTGCT GATCTATAAG 
GGGGGTGAAT TGATCGGCAA TTTTGTTCGT GTTACTGACC AGCTGGGGGA TGATTTCTTT 
GCTGTGGACC TTGAAGCTTT TCTCCAGGAA TTTGGATTAC TCCCAGAAAA GGAAGTCTTG 
GTGCTGACAT CTGTGCGTAA CTCTGCCACG TGTCACAGTG AGGATAGCGA CCTGGAAATA 
GATTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005379.3
CDS	124..1029
Translation	MTTLDDKLLGEKLQYYYSSSEDEDSDHEDKDRGRCAPASSSVPAEAELAGEGISVNTGPKGVINDWRRFKQLETEQREEQCREMERLIKKLSMTCRSHLDEEEEQQKQKDLQEKISGKMTLKEFAIMNEDQDDEEFLQQYRKQRMEEMRQQLHKGPQFKQVFEISSGEGFLDMIDKEQKSIVIMVHIYEDGIPGTEAMNGCMICLAAEYPAVKFCKVKSSVIGASSQFTRNALPALLIYKGGELIGNFVRVTDQLGDDFFAVDLEAFLQEFGLLPEKEVLVLTSVRNSATCHSEDSDLEID

Target ORF information:

RefSeq Version	NM_005388.5
Organism	Homo sapiens(human)
Definition	Homo sapiens phosducin like (PDCL), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005388.5

ORF Insert Sequence:

ATGACCACCC TTGATGATAA GTTGCTGGGG GAGAAACTGC AGTACTACTA TAGCAGCAGT 
GAGGATGAGG ACAGTGACCA CGAGGACAAG GACCGAGGCA GATGTGCCCC AGCCAGCAGT 
TCTGTGCCTG CAGAGGCTGA GCTGGCAGGC GAAGGCATCT CAGTTAACAC AGGCCCAAAA 
GGTGTGATCA ATGACTGGCG CCGCTTCAAG CAGTTGGAGA CAGAGCAGAG GGAGGAGCAG 
TGCCGGGAGA TGGAAAGGCT GATCAAGAAG CTGTCAATGA CTTGCAGGTC CCATCTGGAT 
GAAGAGGAGG AGCAACAGAA ACAGAAAGAC CTCCAGGAGA AGATCAGTGG GAAGATGACT 
CTGAAGGAGT TTGCCATAAT GAATGAGGAC CAAGATGATG AAGAGTTTCT GCAGCAGTAC 
CGGAAGCAGC GAATGGAAGA GATGCGGCAG CAGCTTCACA AGGGGCCCCA ATTCAAGCAG 
GTTTTTGAGA TCTCCAGTGG AGAAGGGTTT TTAGACATGA TTGATAAAGA ACAGAAAAGC 
ATTGTCATCA TGGTTCATAT TTATGAGGAT GGCATTCCAG GGACCGAAGC CATGAATGGT 
TGCATGATCT GCCTTGCCGC AGAGTACCCA GCTGTCAAGT TCTGCAAGGT GAAGAGCTCA 
GTTATTGGCG CCAGCAGTCA GTTCACCAGG AATGCCCTTC CTGCCCTGCT GATCTATAAG 
GGGGGTGAAT TGATCGGCAA TTTTGTTCGT GTTACTGACC AGCTGGGGGA TGATTTCTTT 
GCTGTGGACC TTGAAGCTTT TCTCCAGGAA TTTGGATTAC TCCCAGAAAA GGAAGTCTTG 
GTGCTGACAT CTGTGCGTAA CTCTGCCACG TGTCACAGTG AGGATAGCGA CCTGGAAATA 
GATTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PDCL ( NM_005388.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_005379.3 Homo sapiens phosducin like (PDCL), mRNA.

Price & Availability↑

CloneID	OHu12893
Clone ID Related Accession (Same CDS sequence)	NM_005388.5 , NM_005388.4
Accession Version	NM_005388.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 906bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-22
Organism	Homo sapiens(human)
Product	phosducin-like protein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK313429.1 and AL359512.15. On Jun 29, 2010 this sequence version replaced NM_005388.3. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK313429.1, SRR1803614.244143.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2467144, SAMEA2467146 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGACCACCC TTGATGATAA GTTGCTGGGG GAGAAACTGC AGTACTACTA TAGCAGCAGT 
GAGGATGAGG ACAGTGACCA CGAGGACAAG GACCGAGGCA GATGTGCCCC AGCCAGCAGT 
TCTGTGCCTG CAGAGGCTGA GCTGGCAGGC GAAGGCATCT CAGTTAACAC AGGCCCAAAA 
GGTGTGATCA ATGACTGGCG CCGCTTCAAG CAGTTGGAGA CAGAGCAGAG GGAGGAGCAG 
TGCCGGGAGA TGGAAAGGCT GATCAAGAAG CTGTCAATGA CTTGCAGGTC CCATCTGGAT 
GAAGAGGAGG AGCAACAGAA ACAGAAAGAC CTCCAGGAGA AGATCAGTGG GAAGATGACT 
CTGAAGGAGT TTGCCATAAT GAATGAGGAC CAAGATGATG AAGAGTTTCT GCAGCAGTAC 
CGGAAGCAGC GAATGGAAGA GATGCGGCAG CAGCTTCACA AGGGGCCCCA ATTCAAGCAG 
GTTTTTGAGA TCTCCAGTGG AGAAGGGTTT TTAGACATGA TTGATAAAGA ACAGAAAAGC 
ATTGTCATCA TGGTTCATAT TTATGAGGAT GGCATTCCAG GGACCGAAGC CATGAATGGT 
TGCATGATCT GCCTTGCCGC AGAGTACCCA GCTGTCAAGT TCTGCAAGGT GAAGAGCTCA 
GTTATTGGCG CCAGCAGTCA GTTCACCAGG AATGCCCTTC CTGCCCTGCT GATCTATAAG 
GGGGGTGAAT TGATCGGCAA TTTTGTTCGT GTTACTGACC AGCTGGGGGA TGATTTCTTT 
GCTGTGGACC TTGAAGCTTT TCTCCAGGAA TTTGGATTAC TCCCAGAAAA GGAAGTCTTG 
GTGCTGACAT CTGTGCGTAA CTCTGCCACG TGTCACAGTG AGGATAGCGA CCTGGAAATA 
GATTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005379.3
CDS	192..1097
Translation	MTTLDDKLLGEKLQYYYSSSEDEDSDHEDKDRGRCAPASSSVPAEAELAGEGISVNTGPKGVINDWRRFKQLETEQREEQCREMERLIKKLSMTCRSHLDEEEEQQKQKDLQEKISGKMTLKEFAIMNEDQDDEEFLQQYRKQRMEEMRQQLHKGPQFKQVFEISSGEGFLDMIDKEQKSIVIMVHIYEDGIPGTEAMNGCMICLAAEYPAVKFCKVKSSVIGASSQFTRNALPALLIYKGGELIGNFVRVTDQLGDDFFAVDLEAFLQEFGLLPEKEVLVLTSVRNSATCHSEDSDLEID

Target ORF information:

RefSeq Version	NM_005388.4
Organism	Homo sapiens(human)
Definition	Homo sapiens phosducin like (PDCL), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005388.4

ORF Insert Sequence:

ATGACCACCC TTGATGATAA GTTGCTGGGG GAGAAACTGC AGTACTACTA TAGCAGCAGT 
GAGGATGAGG ACAGTGACCA CGAGGACAAG GACCGAGGCA GATGTGCCCC AGCCAGCAGT 
TCTGTGCCTG CAGAGGCTGA GCTGGCAGGC GAAGGCATCT CAGTTAACAC AGGCCCAAAA 
GGTGTGATCA ATGACTGGCG CCGCTTCAAG CAGTTGGAGA CAGAGCAGAG GGAGGAGCAG 
TGCCGGGAGA TGGAAAGGCT GATCAAGAAG CTGTCAATGA CTTGCAGGTC CCATCTGGAT 
GAAGAGGAGG AGCAACAGAA ACAGAAAGAC CTCCAGGAGA AGATCAGTGG GAAGATGACT 
CTGAAGGAGT TTGCCATAAT GAATGAGGAC CAAGATGATG AAGAGTTTCT GCAGCAGTAC 
CGGAAGCAGC GAATGGAAGA GATGCGGCAG CAGCTTCACA AGGGGCCCCA ATTCAAGCAG 
GTTTTTGAGA TCTCCAGTGG AGAAGGGTTT TTAGACATGA TTGATAAAGA ACAGAAAAGC 
ATTGTCATCA TGGTTCATAT TTATGAGGAT GGCATTCCAG GGACCGAAGC CATGAATGGT 
TGCATGATCT GCCTTGCCGC AGAGTACCCA GCTGTCAAGT TCTGCAAGGT GAAGAGCTCA 
GTTATTGGCG CCAGCAGTCA GTTCACCAGG AATGCCCTTC CTGCCCTGCT GATCTATAAG 
GGGGGTGAAT TGATCGGCAA TTTTGTTCGT GTTACTGACC AGCTGGGGGA TGATTTCTTT 
GCTGTGGACC TTGAAGCTTT TCTCCAGGAA TTTGGATTAC TCCCAGAAAA GGAAGTCTTG 
GTGCTGACAT CTGTGCGTAA CTCTGCCACG TGTCACAGTG AGGATAGCGA CCTGGAAATA 
GATTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PDCL ( XM_017014785.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016870274.1 Homo sapiens phosducin like (PDCL), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu98681
Clone ID Related Accession (Same CDS sequence)	XM_017014785.1
Accession Version	XM_017014785.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 711bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-03-25
Organism	Homo sapiens(human)
Product	phosducin-like protein isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000009.12) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Homo sapiens Annotation Release 109 Annotation Version :: 109 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGATAAGTT GCTGGGGGAG AAACTGCAGT ACTACTATAG CAGCAGTGAG GATGAGGACA 
GTGACCACGA GGACAAGGAC CGAGGCAGAT GTGCCCCAGC CAGCAGTTCT GTGCCTGCAG 
AGGCTGAGCT GGCAGGCGAA GGCATCTCAG TTAACACAGA TGACTCTGAA GGAGTTTGCC 
ATAATGAATG AGGACCAAGA TGATGAAGAG TTTCTGCAGC AGTACCGGAA GCAGCGAATG 
GAAGAGATGC GGCAGCAGCT TCACAAGGGG CCCCAATTCA AGCAGGTTTT TGAGATCTCC 
AGTGGAGAAG GGTTTTTAGA CATGATTGAT AAAGAACAGA AAAGCATTGT CATCATGGTT 
CATATTTATG AGGATGGCAT TCCAGGGACC GAAGCCATGA ATGGTTGCAT GATCTGCCTT 
GCCGCAGAGT ACCCAGCTGT CAAGTTCTGC AAGGTGAAGA GCTCAGTTAT TGGCGCCAGC 
AGTCAGTTCA CCAGGAATGC CCTTCCTGCC CTGCTGATCT ATAAGGGGGG TGAATTGATC 
GGCAATTTTG TTCGTGTTAC TGACCAGCTG GGGGATGATT TCTTTGCTGT GGACCTTGAA 
GCTTTTCTCC AGGAATTTGG ATTACTCCCA GAAAAGGAAG TCTTGGTGCT GACATCTGTG 
CGTAACTCTG CCACGTGTCA CAGTGAGGAT AGCGACCTGG AAATAGATTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016870274.1
CDS	163..873
Translation	MISCWGRNCSTTIAAVRMRTVTTRTRTEADVPQPAVLCLQRLSWQAKASQLTQMTLKEFAIMNEDQDDEEFLQQYRKQRMEEMRQQLHKGPQFKQVFEISSGEGFLDMIDKEQKSIVIMVHIYEDGIPGTEAMNGCMICLAAEYPAVKFCKVKSSVIGASSQFTRNALPALLIYKGGELIGNFVRVTDQLGDDFFAVDLEAFLQEFGLLPEKEVLVLTSVRNSATCHSEDSDLEID

Target ORF information:

RefSeq Version	XM_017014785.1
Organism	Homo sapiens(human)
Definition	Homo sapiens phosducin like (PDCL), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017014785.1

ORF Insert Sequence:

ATGATAAGTT GCTGGGGGAG AAACTGCAGT ACTACTATAG CAGCAGTGAG GATGAGGACA 
GTGACCACGA GGACAAGGAC CGAGGCAGAT GTGCCCCAGC CAGCAGTTCT GTGCCTGCAG 
AGGCTGAGCT GGCAGGCGAA GGCATCTCAG TTAACACAGA TGACTCTGAA GGAGTTTGCC 
ATAATGAATG AGGACCAAGA TGATGAAGAG TTTCTGCAGC AGTACCGGAA GCAGCGAATG 
GAAGAGATGC GGCAGCAGCT TCACAAGGGG CCCCAATTCA AGCAGGTTTT TGAGATCTCC 
AGTGGAGAAG GGTTTTTAGA CATGATTGAT AAAGAACAGA AAAGCATTGT CATCATGGTT 
CATATTTATG AGGATGGCAT TCCAGGGACC GAAGCCATGA ATGGTTGCAT GATCTGCCTT 
GCCGCAGAGT ACCCAGCTGT CAAGTTCTGC AAGGTGAAGA GCTCAGTTAT TGGCGCCAGC 
AGTCAGTTCA CCAGGAATGC CCTTCCTGCC CTGCTGATCT ATAAGGGGGG TGAATTGATC 
GGCAATTTTG TTCGTGTTAC TGACCAGCTG GGGGATGATT TCTTTGCTGT GGACCTTGAA 
GCTTTTCTCC AGGAATTTGG ATTACTCCCA GAAAAGGAAG TCTTGGTGCT GACATCTGTG 
CGTAACTCTG CCACGTGTCA CAGTGAGGAT AGCGACCTGG AAATAGATTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Architecture of the human interactome defines protein communities and disease networks.
Nature545(7655)505-509(2017 05)
Huttlin EL,Bruckner RJ,Paulo JA,Cannon JR,Ting L,Baltier K,Colby G,Gebreab F,Gygi MP,Parzen H,Szpyt J,Tam S,Zarraga G,Pontano-Vaites L,Swarup S,White AE,Schweppe DK,Rad R,Erickson BK,Obar RA,Guruharsha KG,Li K,Artavanis-Tsakonas S,Gygi SP,Harper JW

Structures of the G?-CCT and PhLP1-G?-CCT complexes reveal a mechanism for G-protein ?-subunit folding and G?? dimer assembly.
Proceedings of the National Academy of Sciences of the United States of America112(8)2413-8(2015 Feb)
Plimpton RL,Cu?llar J,Lai CW,Aoba T,Makaju A,Franklin S,Mathis AD,Prince JT,Carrascosa JL,Valpuesta JM,Willardson BM

Programmed cell death protein 5 interacts with the cytosolic chaperonin containing tailless complex polypeptide 1 (CCT) to regulate ?-tubulin folding.
The Journal of biological chemistry289(7)4490-502(2014 Feb)
Tracy CM,Gray AJ,Cu?llar J,Shaw TS,Howlett AC,Taylor RM,Prince JT,Ahn NG,Valpuesta JM,Willardson BM

Splice isoforms of phosducin-like protein control the expression of heterotrimeric G proteins.
The Journal of biological chemistry288(36)25760-8(2013 Sep)
Gao X,Sinha S,Belcastro M,Woodard C,Ramamurthy V,Stoilov P,Sokolov M

Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
PloS one7(12)e51954(2012)
Comuzzie AG,Cole SA,Laston SL,Voruganti VS,Haack K,Gibbs RA,Butte NF

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PDCL cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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