KCNK4 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	KCNK4
Entrez Gene ID	50801
Full Name	potassium two pore domain channel subfamily K member 4
Synonyms	K2p4.1,TRAAK,TRAAK1
General protein information	Preferred Names potassium two pore domain channel subfamily K member 4 Names potassium channel subfamily K member 4 K2P4.1 potassium channel TWIK-related arachidonic acid-stimulated potassium channel protein potassium channel, subfamily K, member 4 potassium channel, two pore domain subfamily K, member 4 two pore K(+) channel KT4.1 two pore K+ channel KT4.1 two pore potassium channel KT4.1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 11 Map Location: 11q13.1
Summary	This gene encodes a member of the TWIK-related arachidonic acid-stimulated two pore potassium channel subfamily. The encoded protein homodimerizes and functions as an outwardly rectifying channel. This channel is regulated by polyunsaturated fatty acids, temperature and mechanical deformation of the lipid membrane. This protein is expressed primarily in neural tissues and may be involved in regulating the noxious input threshold in dorsal root ganglia neurons. Alternate splicing results in multiple transcript variants. Naturally occurring read-through transcripts also exist between this gene and the downstream testis expressed 40 (TEX40) gene, as represented in GeneID: 106780802. [provided by RefSeq, Nov 2015].
Disorder MIM:	605720

mRNA and Protein(s)

mRNA	Protein	Name
NM_033310.2	NP_201567.1	potassium channel subfamily K member 4 precursor
NM_001317090.2	NP_001304019.1	potassium channel subfamily K member 4 precursor
NM_001317090.1	NP_001304019.1	potassium channel subfamily K member 4 precursor
NM_033310.3	NP_201567.1	potassium channel subfamily K member 4 precursor

Pathways from BioSystems

Homologies

Homo sapiens (human)	KCNK4	NP_201567.1
Rattus norvegicus (Norway rat)	Kcnk4	NP_446256.2
	KCNK4	XP_001115007.1
Pan troglodytes (chimpanzee)	KCNK4	XP_001164319.2
Canis lupus familiaris (dog)	KCNK4	XP_005631604.1
Bos taurus (cattle)	KCNK4	XP_002699427.2
Mus musculus (house mouse)	Kcnk4	NP_032457.1
Xenopus tropicalis (tropical clawed frog)	kcnk4	XP_004913694.1

Gene Ontology
Bibliography

Related articles in PubMed

Functional mutagenesis screens reveal the 'cap structure' formation in disulfide-bridge free TASK channels.
Goldstein M, Rinn? S, Kiper AK, Ram?rez D, Netter MF, Bustos D, Ortiz-Bonnin B, Gonz?lez W, Decher N
Scientific reports619492(2016 Jan)

How ion channels sense mechanical force: insights from mechanosensitive K2P channels TRAAK, TREK1, and TREK2.
Brohawn SG
Annals of the New York Academy of Sciences135220-32(2015 Sep)

Racial variation in breast tumor promoter methylation in the Carolina Breast Cancer Study.
Conway K, Edmiston SN, Tse CK, Bryant C, Kuan PF, Hair BY, Parrish EA, May R, Swift-Scanlan T
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology24(6)921-30(2015 Jun)

Transmembrane helix straightening and buckling underlies activation of mechanosensitive and thermosensitive K(2P) channels.
Lolicato M, Riegelhaupt PM, Arrigoni C, Clark KA, Minor DL Jr
Neuron84(6)1198-212(2014 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Functional alanine-mutagenesis screens of TASK-1 and TRAAK were used to build an in silico model of the TASK-1 cap.
Title: Functional mutagenesis screens reveal the 'cap structure' formation in disulfide-bridge free TASK channels.

How ion channels sense mechanical force: insights from mechanosensitive K2P channels TRAAK, TREK1, and TREK2.
Title: How ion channels sense mechanical force: insights from mechanosensitive K2P channels TRAAK, TREK1, and TREK2.

KCNK4 promoter methylation is associated with Breast Cancer.
Title: Racial variation in breast tumor promoter methylation in the Carolina Breast Cancer Study.

findings uncover a unique aspect of potassium channel modulation, indicate a means for how the channel C-terminal cytoplasmic domain affects the C-type gate, and suggest how lipids and bilayer inner leaflet deformations gate the channel.
Title: Transmembrane helix straightening and buckling underlies activation of mechanosensitive and thermosensitive K(2P) channels.

TRAAK is responsive to mechanical forces similar to the ion channel Piezo1; mechanical activation of TRAAK can electrically counter Piezo1 activation.
Title: Mechanosensitivity is mediated directly by the lipid membrane in TRAAK and TREK1 K+ channels.

The following KCNK4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the KCNK4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu27815	NM_001317090.2 Latest version!	Homo sapiens potassium two pore domain channel subfamily K member 4 (KCNK4), transcript variant 6, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$164.50-$230.30 $329.00
OHu27815	NM_033310.3 Latest version!	Homo sapiens potassium two pore domain channel subfamily K member 4 (KCNK4), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$164.50-$230.30 $329.00
View Old Accession Versions >>
OHu27815	NM_001317090.1	Homo sapiens potassium two pore domain channel subfamily K member 4 (KCNK4), transcript variant 6, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$164.50-$230.30 $329.00
OHu27815	NM_033310.2	Homo sapiens potassium two pore domain channel subfamily K member 4 (KCNK4), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$164.50-$230.30 $329.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

KCNK4 ( NM_033310.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_201567.1 Homo sapiens potassium two pore domain channel subfamily K member 4 (KCNK4), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu27815
Clone ID Related Accession (Same CDS sequence)	NM_033310.2 , NM_001317090.2 , NM_001317090.1 , NM_033310.3
Accession Version	NM_033310.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1182bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	potassium channel subfamily K member 4 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB273064.1, AP001453.6, BC067791.1, AF259500.1 and BC110327.1. On or before Nov 17, 2015 this sequence version replaced NM_033311.1, NM_033310.1. Transcript Variant: This variant (2) encodes the functional protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF259500.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2154665 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

ATGCGCAGCA CCACGCTCCT GGCCCTGCTG GCGCTGGTCT TGCTTTACTT GGTGTCTGGT 
GCCCTGGTGT TCCGGGCCCT GGAGCAGCCC CACGAGCAGC AGGCCCAGAG GGAGCTGGGG 
GAGGTCCGAG AGAAGTTCCT GAGGGCCCAT CCGTGTGTGA GCGACCAGGA GCTGGGCCTC 
CTCATCAAGG AGGTGGCTGA TGCCCTGGGA GGGGGTGCGG ACCCAGAAAC CAACTCGACC 
AGCAACAGCA GCCACTCAGC CTGGGACCTG GGCAGCGCCT TCTTTTTCTC AGGGACCATC 
ATCACCACCA TCGGCTATGG CAATGTGGCC CTGCGCACAG ATGCCGGGCG CCTCTTCTGC 
ATCTTTTATG CGCTGGTGGG GATTCCGCTG TTTGGGATCC TACTGGCAGG GGTCGGGGAC 
CGGCTGGGCT CCTCCCTGCG CCATGGCATC GGTCACATTG AAGCCATCTT CTTGAAGTGG 
CACGTGCCAC CGGAGCTAGT AAGAGTGCTG TCGGCGATGC TTTTCCTGCT GATCGGCTGC 
CTGCTCTTTG TCCTCACGCC CACGTTCGTG TTCTGCTATA TGGAGGACTG GAGCAAGCTG 
GAGGCCATCT ACTTTGTCAT AGTGACGCTT ACCACCGTGG GCTTTGGCGA CTATGTGGCC 
GGCGCGGACC CCAGGCAGGA CTCCCCGGCC TATCAGCCGC TGGTGTGGTT CTGGATCCTG 
CTCGGCCTGG CTTACTTCGC CTCAGTGCTC ACCACCATCG GGAACTGGCT GCGAGTAGTG 
TCCCGCCGCA CTCGGGCAGA GATGGGCGGC CTCACGGCTC AGGCTGCCAG CTGGACTGGC 
ACGGTGACAG CGCGCGTGAC CCAGCGAGCC GGGCCCGCCG CCCCGCCGCC GGAGAAGGAG 
CAGCCACTGC TGCCTCCACC GCCCTGTCCA GCGCAGCCGC TGGGCAGGCC CCGATCCCCT 
TCGCCCCCCG AGAAGGCTCA GCCGCCTTCC CCGCCCACGG CCTCGGCCCT GGATTATCCC 
AGCGAGAACC TGGCCTTCAT CGACGAGTCC TCGGATACGC AGAGCGAGCG CGGCTGCCCG 
CTGCCCCGCG CGCCGAGAGG TCGCCGCCGC CCAAATCCCC CCAGGAAGCC CGTGCGGCCC 
CGCGGCCCCG GGCGTCCCCG AGACAAAGGC GTGCCGGTGT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_201567.1
CDS	324..1505
Translation	MRSTTLLALLALVLLYLVSGALVFRALEQPHEQQAQRELGEVREKFLRAHPCVSDQELGLLIKEVADALGGGADPETNSTSNSSHSAWDLGSAFFFSGTIITTIGYGNVALRTDAGRLFCIFYALVGIPLFGILLAGVGDRLGSSLRHGIGHIEAIFLKWHVPPELVRVLSAMLFLLIGCLLFVLTPTFVFCYMEDWSKLEAIYFVIVTLTTVGFGDYVAGADPRQDSPAYQPLVWFWILLGLAYFASVLTTIGNWLRVVSRRTRAEMGGLTAQAASWTGTVTARVTQRAGPAAPPPEKEQPLLPPPPCPAQPLGRPRSPSPPEKAQPPSPPTASALDYPSENLAFIDESSDTQSERGCPLPRAPRGRRRPNPPRKPVRPRGPGRPRDKGVPV

Target ORF information:

RefSeq Version	NM_033310.2
Organism	Homo sapiens(human)
Definition	Homo sapiens potassium two pore domain channel subfamily K member 4 (KCNK4), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_033310.2

ORF Insert Sequence:

ATGCGCAGCA CCACGCTCCT GGCCCTGCTG GCGCTGGTCT TGCTTTACTT GGTGTCTGGT 
GCCCTGGTGT TCCGGGCCCT GGAGCAGCCC CACGAGCAGC AGGCCCAGAG GGAGCTGGGG 
GAGGTCCGAG AGAAGTTCCT GAGGGCCCAT CCGTGTGTGA GCGACCAGGA GCTGGGCCTC 
CTCATCAAGG AGGTGGCTGA TGCCCTGGGA GGGGGTGCGG ACCCAGAAAC CAACTCGACC 
AGCAACAGCA GCCACTCAGC CTGGGACCTG GGCAGCGCCT TCTTTTTCTC AGGGACCATC 
ATCACCACCA TCGGCTATGG CAATGTGGCC CTGCGCACAG ATGCCGGGCG CCTCTTCTGC 
ATCTTTTATG CGCTGGTGGG GATTCCGCTG TTTGGGATCC TACTGGCAGG GGTCGGGGAC 
CGGCTGGGCT CCTCCCTGCG CCATGGCATC GGTCACATTG AAGCCATCTT CTTGAAGTGG 
CACGTGCCAC CGGAGCTAGT AAGAGTGCTG TCGGCGATGC TTTTCCTGCT GATCGGCTGC 
CTGCTCTTTG TCCTCACGCC CACGTTCGTG TTCTGCTATA TGGAGGACTG GAGCAAGCTG 
GAGGCCATCT ACTTTGTCAT AGTGACGCTT ACCACCGTGG GCTTTGGCGA CTATGTGGCC 
GGCGCGGACC CCAGGCAGGA CTCCCCGGCC TATCAGCCGC TGGTGTGGTT CTGGATCCTG 
CTCGGCCTGG CTTACTTCGC CTCAGTGCTC ACCACCATCG GGAACTGGCT GCGAGTAGTG 
TCCCGCCGCA CTCGGGCAGA GATGGGCGGC CTCACGGCTC AGGCTGCCAG CTGGACTGGC 
ACGGTGACAG CGCGCGTGAC CCAGCGAGCC GGGCCCGCCG CCCCGCCGCC GGAGAAGGAG 
CAGCCACTGC TGCCTCCACC GCCCTGTCCA GCGCAGCCGC TGGGCAGGCC CCGATCCCCT 
TCGCCCCCCG AGAAGGCTCA GCCGCCTTCC CCGCCCACGG CCTCGGCCCT GGATTATCCC 
AGCGAGAACC TGGCCTTCAT CGACGAGTCC TCGGATACGC AGAGCGAGCG CGGCTGCCCG 
CTGCCCCGCG CGCCGAGAGG TCGCCGCCGC CCAAATCCCC CCAGGAAGCC CGTGCGGCCC 
CGCGGCCCCG GGCGTCCCCG AGACAAAGGC GTGCCGGTGT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

KCNK4 ( NM_001317090.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001304019.1 Homo sapiens potassium two pore domain channel subfamily K member 4 (KCNK4), transcript variant 6, mRNA.

Price & Availability↑

CloneID	OHu27815
Clone ID Related Accession (Same CDS sequence)	NM_033310.2 , NM_001317090.2 , NM_001317090.1 , NM_033310.3
Accession Version	NM_001317090.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1182bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-03
Organism	Homo sapiens(human)
Product	potassium channel subfamily K member 4 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AP001453.6 and BC110327.1. On May 31, 2019 this sequence version replaced NM_001317090.1. Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 2. Both variants 2 and 4 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC110327.1 [ECO:0000332] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCGCAGCA CCACGCTCCT GGCCCTGCTG GCGCTGGTCT TGCTTTACTT GGTGTCTGGT 
GCCCTGGTGT TCCGGGCCCT GGAGCAGCCC CACGAGCAGC AGGCCCAGAG GGAGCTGGGG 
GAGGTCCGAG AGAAGTTCCT GAGGGCCCAT CCGTGTGTGA GCGACCAGGA GCTGGGCCTC 
CTCATCAAGG AGGTGGCTGA TGCCCTGGGA GGGGGTGCGG ACCCAGAAAC CAACTCGACC 
AGCAACAGCA GCCACTCAGC CTGGGACCTG GGCAGCGCCT TCTTTTTCTC AGGGACCATC 
ATCACCACCA TCGGCTATGG CAATGTGGCC CTGCGCACAG ATGCCGGGCG CCTCTTCTGC 
ATCTTTTATG CGCTGGTGGG GATTCCGCTG TTTGGGATCC TACTGGCAGG GGTCGGGGAC 
CGGCTGGGCT CCTCCCTGCG CCATGGCATC GGTCACATTG AAGCCATCTT CTTGAAGTGG 
CACGTGCCAC CGGAGCTAGT AAGAGTGCTG TCGGCGATGC TTTTCCTGCT GATCGGCTGC 
CTGCTCTTTG TCCTCACGCC CACGTTCGTG TTCTGCTATA TGGAGGACTG GAGCAAGCTG 
GAGGCCATCT ACTTTGTCAT AGTGACGCTT ACCACCGTGG GCTTTGGCGA CTATGTGGCC 
GGCGCGGACC CCAGGCAGGA CTCCCCGGCC TATCAGCCGC TGGTGTGGTT CTGGATCCTG 
CTCGGCCTGG CTTACTTCGC CTCAGTGCTC ACCACCATCG GGAACTGGCT GCGAGTAGTG 
TCCCGCCGCA CTCGGGCAGA GATGGGCGGC CTCACGGCTC AGGCTGCCAG CTGGACTGGC 
ACGGTGACAG CGCGCGTGAC CCAGCGAGCC GGGCCCGCCG CCCCGCCGCC GGAGAAGGAG 
CAGCCACTGC TGCCTCCACC GCCCTGTCCA GCGCAGCCGC TGGGCAGGCC CCGATCCCCT 
TCGCCCCCCG AGAAGGCTCA GCCGCCTTCC CCGCCCACGG CCTCGGCCCT GGATTATCCC 
AGCGAGAACC TGGCCTTCAT CGACGAGTCC TCGGATACGC AGAGCGAGCG CGGCTGCCCG 
CTGCCCCGCG CGCCGAGAGG TCGCCGCCGC CCAAATCCCC CCAGGAAGCC CGTGCGGCCC 
CGCGGCCCCG GGCGTCCCCG AGACAAAGGC GTGCCGGTGT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001304019.1
CDS	199..1380
Translation	MRSTTLLALLALVLLYLVSGALVFRALEQPHEQQAQRELGEVREKFLRAHPCVSDQELGLLIKEVADALGGGADPETNSTSNSSHSAWDLGSAFFFSGTIITTIGYGNVALRTDAGRLFCIFYALVGIPLFGILLAGVGDRLGSSLRHGIGHIEAIFLKWHVPPELVRVLSAMLFLLIGCLLFVLTPTFVFCYMEDWSKLEAIYFVIVTLTTVGFGDYVAGADPRQDSPAYQPLVWFWILLGLAYFASVLTTIGNWLRVVSRRTRAEMGGLTAQAASWTGTVTARVTQRAGPAAPPPEKEQPLLPPPPCPAQPLGRPRSPSPPEKAQPPSPPTASALDYPSENLAFIDESSDTQSERGCPLPRAPRGRRRPNPPRKPVRPRGPGRPRDKGVPV

Target ORF information:

RefSeq Version	NM_001317090.2
Organism	Homo sapiens(human)
Definition	Homo sapiens potassium two pore domain channel subfamily K member 4 (KCNK4), transcript variant 6, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001317090.2

ORF Insert Sequence:

ATGCGCAGCA CCACGCTCCT GGCCCTGCTG GCGCTGGTCT TGCTTTACTT GGTGTCTGGT 
GCCCTGGTGT TCCGGGCCCT GGAGCAGCCC CACGAGCAGC AGGCCCAGAG GGAGCTGGGG 
GAGGTCCGAG AGAAGTTCCT GAGGGCCCAT CCGTGTGTGA GCGACCAGGA GCTGGGCCTC 
CTCATCAAGG AGGTGGCTGA TGCCCTGGGA GGGGGTGCGG ACCCAGAAAC CAACTCGACC 
AGCAACAGCA GCCACTCAGC CTGGGACCTG GGCAGCGCCT TCTTTTTCTC AGGGACCATC 
ATCACCACCA TCGGCTATGG CAATGTGGCC CTGCGCACAG ATGCCGGGCG CCTCTTCTGC 
ATCTTTTATG CGCTGGTGGG GATTCCGCTG TTTGGGATCC TACTGGCAGG GGTCGGGGAC 
CGGCTGGGCT CCTCCCTGCG CCATGGCATC GGTCACATTG AAGCCATCTT CTTGAAGTGG 
CACGTGCCAC CGGAGCTAGT AAGAGTGCTG TCGGCGATGC TTTTCCTGCT GATCGGCTGC 
CTGCTCTTTG TCCTCACGCC CACGTTCGTG TTCTGCTATA TGGAGGACTG GAGCAAGCTG 
GAGGCCATCT ACTTTGTCAT AGTGACGCTT ACCACCGTGG GCTTTGGCGA CTATGTGGCC 
GGCGCGGACC CCAGGCAGGA CTCCCCGGCC TATCAGCCGC TGGTGTGGTT CTGGATCCTG 
CTCGGCCTGG CTTACTTCGC CTCAGTGCTC ACCACCATCG GGAACTGGCT GCGAGTAGTG 
TCCCGCCGCA CTCGGGCAGA GATGGGCGGC CTCACGGCTC AGGCTGCCAG CTGGACTGGC 
ACGGTGACAG CGCGCGTGAC CCAGCGAGCC GGGCCCGCCG CCCCGCCGCC GGAGAAGGAG 
CAGCCACTGC TGCCTCCACC GCCCTGTCCA GCGCAGCCGC TGGGCAGGCC CCGATCCCCT 
TCGCCCCCCG AGAAGGCTCA GCCGCCTTCC CCGCCCACGG CCTCGGCCCT GGATTATCCC 
AGCGAGAACC TGGCCTTCAT CGACGAGTCC TCGGATACGC AGAGCGAGCG CGGCTGCCCG 
CTGCCCCGCG CGCCGAGAGG TCGCCGCCGC CCAAATCCCC CCAGGAAGCC CGTGCGGCCC 
CGCGGCCCCG GGCGTCCCCG AGACAAAGGC GTGCCGGTGT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

KCNK4 ( NM_001317090.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001304019.1 Homo sapiens potassium two pore domain channel subfamily K member 4 (KCNK4), transcript variant 6, mRNA.

Price & Availability↑

CloneID	OHu27815
Clone ID Related Accession (Same CDS sequence)	NM_033310.2 , NM_001317090.2 , NM_001317090.1 , NM_033310.3
Accession Version	NM_001317090.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1182bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-24
Organism	Homo sapiens(human)
Product	potassium channel subfamily K member 4 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC110327.1 and AP001453.6. Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 2. Both variants 2 and 4 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC110327.1 [ECO:0000332] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCGCAGCA CCACGCTCCT GGCCCTGCTG GCGCTGGTCT TGCTTTACTT GGTGTCTGGT 
GCCCTGGTGT TCCGGGCCCT GGAGCAGCCC CACGAGCAGC AGGCCCAGAG GGAGCTGGGG 
GAGGTCCGAG AGAAGTTCCT GAGGGCCCAT CCGTGTGTGA GCGACCAGGA GCTGGGCCTC 
CTCATCAAGG AGGTGGCTGA TGCCCTGGGA GGGGGTGCGG ACCCAGAAAC CAACTCGACC 
AGCAACAGCA GCCACTCAGC CTGGGACCTG GGCAGCGCCT TCTTTTTCTC AGGGACCATC 
ATCACCACCA TCGGCTATGG CAATGTGGCC CTGCGCACAG ATGCCGGGCG CCTCTTCTGC 
ATCTTTTATG CGCTGGTGGG GATTCCGCTG TTTGGGATCC TACTGGCAGG GGTCGGGGAC 
CGGCTGGGCT CCTCCCTGCG CCATGGCATC GGTCACATTG AAGCCATCTT CTTGAAGTGG 
CACGTGCCAC CGGAGCTAGT AAGAGTGCTG TCGGCGATGC TTTTCCTGCT GATCGGCTGC 
CTGCTCTTTG TCCTCACGCC CACGTTCGTG TTCTGCTATA TGGAGGACTG GAGCAAGCTG 
GAGGCCATCT ACTTTGTCAT AGTGACGCTT ACCACCGTGG GCTTTGGCGA CTATGTGGCC 
GGCGCGGACC CCAGGCAGGA CTCCCCGGCC TATCAGCCGC TGGTGTGGTT CTGGATCCTG 
CTCGGCCTGG CTTACTTCGC CTCAGTGCTC ACCACCATCG GGAACTGGCT GCGAGTAGTG 
TCCCGCCGCA CTCGGGCAGA GATGGGCGGC CTCACGGCTC AGGCTGCCAG CTGGACTGGC 
ACGGTGACAG CGCGCGTGAC CCAGCGAGCC GGGCCCGCCG CCCCGCCGCC GGAGAAGGAG 
CAGCCACTGC TGCCTCCACC GCCCTGTCCA GCGCAGCCGC TGGGCAGGCC CCGATCCCCT 
TCGCCCCCCG AGAAGGCTCA GCCGCCTTCC CCGCCCACGG CCTCGGCCCT GGATTATCCC 
AGCGAGAACC TGGCCTTCAT CGACGAGTCC TCGGATACGC AGAGCGAGCG CGGCTGCCCG 
CTGCCCCGCG CGCCGAGAGG TCGCCGCCGC CCAAATCCCC CCAGGAAGCC CGTGCGGCCC 
CGCGGCCCCG GGCGTCCCCG AGACAAAGGC GTGCCGGTGT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001304019.1
CDS	187..1368
Translation	MRSTTLLALLALVLLYLVSGALVFRALEQPHEQQAQRELGEVREKFLRAHPCVSDQELGLLIKEVADALGGGADPETNSTSNSSHSAWDLGSAFFFSGTIITTIGYGNVALRTDAGRLFCIFYALVGIPLFGILLAGVGDRLGSSLRHGIGHIEAIFLKWHVPPELVRVLSAMLFLLIGCLLFVLTPTFVFCYMEDWSKLEAIYFVIVTLTTVGFGDYVAGADPRQDSPAYQPLVWFWILLGLAYFASVLTTIGNWLRVVSRRTRAEMGGLTAQAASWTGTVTARVTQRAGPAAPPPEKEQPLLPPPPCPAQPLGRPRSPSPPEKAQPPSPPTASALDYPSENLAFIDESSDTQSERGCPLPRAPRGRRRPNPPRKPVRPRGPGRPRDKGVPV

Target ORF information:

RefSeq Version	NM_001317090.1
Organism	Homo sapiens(human)
Definition	Homo sapiens potassium two pore domain channel subfamily K member 4 (KCNK4), transcript variant 6, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001317090.1

ORF Insert Sequence:

ATGCGCAGCA CCACGCTCCT GGCCCTGCTG GCGCTGGTCT TGCTTTACTT GGTGTCTGGT 
GCCCTGGTGT TCCGGGCCCT GGAGCAGCCC CACGAGCAGC AGGCCCAGAG GGAGCTGGGG 
GAGGTCCGAG AGAAGTTCCT GAGGGCCCAT CCGTGTGTGA GCGACCAGGA GCTGGGCCTC 
CTCATCAAGG AGGTGGCTGA TGCCCTGGGA GGGGGTGCGG ACCCAGAAAC CAACTCGACC 
AGCAACAGCA GCCACTCAGC CTGGGACCTG GGCAGCGCCT TCTTTTTCTC AGGGACCATC 
ATCACCACCA TCGGCTATGG CAATGTGGCC CTGCGCACAG ATGCCGGGCG CCTCTTCTGC 
ATCTTTTATG CGCTGGTGGG GATTCCGCTG TTTGGGATCC TACTGGCAGG GGTCGGGGAC 
CGGCTGGGCT CCTCCCTGCG CCATGGCATC GGTCACATTG AAGCCATCTT CTTGAAGTGG 
CACGTGCCAC CGGAGCTAGT AAGAGTGCTG TCGGCGATGC TTTTCCTGCT GATCGGCTGC 
CTGCTCTTTG TCCTCACGCC CACGTTCGTG TTCTGCTATA TGGAGGACTG GAGCAAGCTG 
GAGGCCATCT ACTTTGTCAT AGTGACGCTT ACCACCGTGG GCTTTGGCGA CTATGTGGCC 
GGCGCGGACC CCAGGCAGGA CTCCCCGGCC TATCAGCCGC TGGTGTGGTT CTGGATCCTG 
CTCGGCCTGG CTTACTTCGC CTCAGTGCTC ACCACCATCG GGAACTGGCT GCGAGTAGTG 
TCCCGCCGCA CTCGGGCAGA GATGGGCGGC CTCACGGCTC AGGCTGCCAG CTGGACTGGC 
ACGGTGACAG CGCGCGTGAC CCAGCGAGCC GGGCCCGCCG CCCCGCCGCC GGAGAAGGAG 
CAGCCACTGC TGCCTCCACC GCCCTGTCCA GCGCAGCCGC TGGGCAGGCC CCGATCCCCT 
TCGCCCCCCG AGAAGGCTCA GCCGCCTTCC CCGCCCACGG CCTCGGCCCT GGATTATCCC 
AGCGAGAACC TGGCCTTCAT CGACGAGTCC TCGGATACGC AGAGCGAGCG CGGCTGCCCG 
CTGCCCCGCG CGCCGAGAGG TCGCCGCCGC CCAAATCCCC CCAGGAAGCC CGTGCGGCCC 
CGCGGCCCCG GGCGTCCCCG AGACAAAGGC GTGCCGGTGT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

KCNK4 ( NM_033310.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_201567.1 Homo sapiens potassium two pore domain channel subfamily K member 4 (KCNK4), transcript variant 2, mRNA.

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CloneID	OHu27815
Clone ID Related Accession (Same CDS sequence)	NM_033310.2 , NM_001317090.2 , NM_001317090.1 , NM_033310.3
Accession Version	NM_033310.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1182bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Homo sapiens(human)
Product	potassium channel subfamily K member 4 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AP001453.6, DB273064.1, BC067791.1, AF259500.1 and BC110327.1. On Nov 22, 2018 this sequence version replaced NM_033310.2. Transcript Variant: This variant (2) encodes the functional protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF259500.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2154665 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000422670.7/ ENSP00000402797.2 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGCGCAGCA CCACGCTCCT GGCCCTGCTG GCGCTGGTCT TGCTTTACTT GGTGTCTGGT 
GCCCTGGTGT TCCGGGCCCT GGAGCAGCCC CACGAGCAGC AGGCCCAGAG GGAGCTGGGG 
GAGGTCCGAG AGAAGTTCCT GAGGGCCCAT CCGTGTGTGA GCGACCAGGA GCTGGGCCTC 
CTCATCAAGG AGGTGGCTGA TGCCCTGGGA GGGGGTGCGG ACCCAGAAAC CAACTCGACC 
AGCAACAGCA GCCACTCAGC CTGGGACCTG GGCAGCGCCT TCTTTTTCTC AGGGACCATC 
ATCACCACCA TCGGCTATGG CAATGTGGCC CTGCGCACAG ATGCCGGGCG CCTCTTCTGC 
ATCTTTTATG CGCTGGTGGG GATTCCGCTG TTTGGGATCC TACTGGCAGG GGTCGGGGAC 
CGGCTGGGCT CCTCCCTGCG CCATGGCATC GGTCACATTG AAGCCATCTT CTTGAAGTGG 
CACGTGCCAC CGGAGCTAGT AAGAGTGCTG TCGGCGATGC TTTTCCTGCT GATCGGCTGC 
CTGCTCTTTG TCCTCACGCC CACGTTCGTG TTCTGCTATA TGGAGGACTG GAGCAAGCTG 
GAGGCCATCT ACTTTGTCAT AGTGACGCTT ACCACCGTGG GCTTTGGCGA CTATGTGGCC 
GGCGCGGACC CCAGGCAGGA CTCCCCGGCC TATCAGCCGC TGGTGTGGTT CTGGATCCTG 
CTCGGCCTGG CTTACTTCGC CTCAGTGCTC ACCACCATCG GGAACTGGCT GCGAGTAGTG 
TCCCGCCGCA CTCGGGCAGA GATGGGCGGC CTCACGGCTC AGGCTGCCAG CTGGACTGGC 
ACGGTGACAG CGCGCGTGAC CCAGCGAGCC GGGCCCGCCG CCCCGCCGCC GGAGAAGGAG 
CAGCCACTGC TGCCTCCACC GCCCTGTCCA GCGCAGCCGC TGGGCAGGCC CCGATCCCCT 
TCGCCCCCCG AGAAGGCTCA GCCGCCTTCC CCGCCCACGG CCTCGGCCCT GGATTATCCC 
AGCGAGAACC TGGCCTTCAT CGACGAGTCC TCGGATACGC AGAGCGAGCG CGGCTGCCCG 
CTGCCCCGCG CGCCGAGAGG TCGCCGCCGC CCAAATCCCC CCAGGAAGCC CGTGCGGCCC 
CGCGGCCCCG GGCGTCCCCG AGACAAAGGC GTGCCGGTGT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_201567.1
CDS	343..1524
Translation	MRSTTLLALLALVLLYLVSGALVFRALEQPHEQQAQRELGEVREKFLRAHPCVSDQELGLLIKEVADALGGGADPETNSTSNSSHSAWDLGSAFFFSGTIITTIGYGNVALRTDAGRLFCIFYALVGIPLFGILLAGVGDRLGSSLRHGIGHIEAIFLKWHVPPELVRVLSAMLFLLIGCLLFVLTPTFVFCYMEDWSKLEAIYFVIVTLTTVGFGDYVAGADPRQDSPAYQPLVWFWILLGLAYFASVLTTIGNWLRVVSRRTRAEMGGLTAQAASWTGTVTARVTQRAGPAAPPPEKEQPLLPPPPCPAQPLGRPRSPSPPEKAQPPSPPTASALDYPSENLAFIDESSDTQSERGCPLPRAPRGRRRPNPPRKPVRPRGPGRPRDKGVPV

Target ORF information:

RefSeq Version	NM_033310.3
Organism	Homo sapiens(human)
Definition	Homo sapiens potassium two pore domain channel subfamily K member 4 (KCNK4), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_033310.3

ORF Insert Sequence:

ATGCGCAGCA CCACGCTCCT GGCCCTGCTG GCGCTGGTCT TGCTTTACTT GGTGTCTGGT 
GCCCTGGTGT TCCGGGCCCT GGAGCAGCCC CACGAGCAGC AGGCCCAGAG GGAGCTGGGG 
GAGGTCCGAG AGAAGTTCCT GAGGGCCCAT CCGTGTGTGA GCGACCAGGA GCTGGGCCTC 
CTCATCAAGG AGGTGGCTGA TGCCCTGGGA GGGGGTGCGG ACCCAGAAAC CAACTCGACC 
AGCAACAGCA GCCACTCAGC CTGGGACCTG GGCAGCGCCT TCTTTTTCTC AGGGACCATC 
ATCACCACCA TCGGCTATGG CAATGTGGCC CTGCGCACAG ATGCCGGGCG CCTCTTCTGC 
ATCTTTTATG CGCTGGTGGG GATTCCGCTG TTTGGGATCC TACTGGCAGG GGTCGGGGAC 
CGGCTGGGCT CCTCCCTGCG CCATGGCATC GGTCACATTG AAGCCATCTT CTTGAAGTGG 
CACGTGCCAC CGGAGCTAGT AAGAGTGCTG TCGGCGATGC TTTTCCTGCT GATCGGCTGC 
CTGCTCTTTG TCCTCACGCC CACGTTCGTG TTCTGCTATA TGGAGGACTG GAGCAAGCTG 
GAGGCCATCT ACTTTGTCAT AGTGACGCTT ACCACCGTGG GCTTTGGCGA CTATGTGGCC 
GGCGCGGACC CCAGGCAGGA CTCCCCGGCC TATCAGCCGC TGGTGTGGTT CTGGATCCTG 
CTCGGCCTGG CTTACTTCGC CTCAGTGCTC ACCACCATCG GGAACTGGCT GCGAGTAGTG 
TCCCGCCGCA CTCGGGCAGA GATGGGCGGC CTCACGGCTC AGGCTGCCAG CTGGACTGGC 
ACGGTGACAG CGCGCGTGAC CCAGCGAGCC GGGCCCGCCG CCCCGCCGCC GGAGAAGGAG 
CAGCCACTGC TGCCTCCACC GCCCTGTCCA GCGCAGCCGC TGGGCAGGCC CCGATCCCCT 
TCGCCCCCCG AGAAGGCTCA GCCGCCTTCC CCGCCCACGG CCTCGGCCCT GGATTATCCC 
AGCGAGAACC TGGCCTTCAT CGACGAGTCC TCGGATACGC AGAGCGAGCG CGGCTGCCCG 
CTGCCCCGCG CGCCGAGAGG TCGCCGCCGC CCAAATCCCC CCAGGAAGCC CGTGCGGCCC 
CGCGGCCCCG GGCGTCCCCG AGACAAAGGC GTGCCGGTGT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Functional mutagenesis screens reveal the 'cap structure' formation in disulfide-bridge free TASK channels.
Scientific reports619492(2016 Jan)
Goldstein M,Rinn? S,Kiper AK,Ram?rez D,Netter MF,Bustos D,Ortiz-Bonnin B,Gonz?lez W,Decher N

How ion channels sense mechanical force: insights from mechanosensitive K2P channels TRAAK, TREK1, and TREK2.
Annals of the New York Academy of Sciences135220-32(2015 Sep)
Brohawn SG

Racial variation in breast tumor promoter methylation in the Carolina Breast Cancer Study.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology24(6)921-30(2015 Jun)
Conway K,Edmiston SN,Tse CK,Bryant C,Kuan PF,Hair BY,Parrish EA,May R,Swift-Scanlan T

Transmembrane helix straightening and buckling underlies activation of mechanosensitive and thermosensitive K(2P) channels.
Neuron84(6)1198-212(2014 Dec)
Lolicato M,Riegelhaupt PM,Arrigoni C,Clark KA,Minor DL Jr

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KCNK4 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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