CUZD1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	CUZD1
Entrez Gene ID	50624
Full Name	CUB and zona pellucida like domains 1
Synonyms	ERG-1,ERG1,ITMAP1,UO-44
General protein information	Preferred Names CUB and zona pellucida like domains 1 Names CUB and zona pellucida-like domain-containing protein 1 CUB and ZP domain-containing protein 1 estrogen regulated gene 1 transmembrane protein UO-44
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 10 Map Location: 10q26.13
Disorder MIM:	616644

mRNA and Protein(s)

mRNA	Protein	Name
NM_022034.5	NP_071317.2	CUB and zona pellucida-like domain-containing protein 1 precursor
NM_022034.6	NP_071317.2	CUB and zona pellucida-like domain-containing protein 1 precursor

Pathways from BioSystems

Homologies

Homo sapiens (human)	CUZD1	NP_071317.2
Mus musculus (house mouse)	Cuzd1	NP_032437.3
Rattus norvegicus (Norway rat)	Cuzd1	NP_446457.1
Danio rerio (zebrafish)	wu:fb66a12	XP_684059.2
Xenopus tropicalis (tropical clawed frog)	LOC101733966	XP_004920959.1
	CUZD1	XP_001103890.1
Canis lupus familiaris (dog)	CUZD1	XP_544054.2
Danio rerio (zebrafish)	LOC555768	XP_683476.4
Xenopus tropicalis (tropical clawed frog)	LOC100485179	XP_002937840.2
Pan troglodytes (chimpanzee)	CUZD1	XP_001160209.2
Danio rerio (zebrafish)	LOC101886384	XP_005158771.1

Gene Ontology
Bibliography

Related articles in PubMed

Aberrantly high expression of the CUB and zona pellucida-like domain-containing protein 1 (CUZD1) in mammary epithelium leads to breast tumorigenesis.
Mapes J, Anandan L, Li Q, Neff A, Clevenger CV, Bagchi IC, Bagchi MK
The Journal of biological chemistry(2018 Jan)

Generation of monoclonal antibodies and development of an immunofluorometric assay for the detection of CUZD1 in tissues and biological fluids.
Farkona S, Soosaipillai A, Filippou P, Korbakis D, Serra S, R?ckert F, Diamandis EP, Blasutig IM
Clinical biochemistry50(18)1168-1174(2017 Dec)

Rediscovery of the Anti-Pancreatic Antibodies and Evaluation of their Prognostic Value in a Prospective Clinical Cohort of Crohn's Patients: The Importance of Specific Target Antigens [GP2 and CUZD1].
Papp M, Sipeki N, Tornai T, Altorjay I, Norman GL, Shums Z, Roggenbuck D, Fechner K, St?cker W, Antal-Szalmas P, Veres G, Lakatos PL
Journal of Crohn's & colitis9(8)659-68(2015 Aug)

CUZD1 and anti-CUZD1 antibodies as markers of cancer and inflammatory bowel diseases.
Liaskos C, Rigopoulou EI, Orfanidou T, Bogdanos DP, Papandreou CN
Clinical & developmental immunology2013968041(2013)

CUB and zona pellucida-like domain-containing protein 1 (CUZD1): a novel serological biomarker for ovarian cancer.
Leung F, Soosaipillai A, Kulasingam V, Diamandis EP
Clinical biochemistry45(18)1543-6(2012 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

This study describes the development of tools targeting CUZD1 protein, its tissue expression pattern and levels in several biological fluids. These new tools will facilitate future investigations aiming to delineate the role of CUZD1 in physiology and pathobiology.
Title: Generation of monoclonal antibodies and development of an immunofluorometric assay for the detection of CUZD1 in tissues and biological fluids.

Totals of 12.4% and 20.8% of Crohn's disease patients were positive for IgA/IgG type of anti-GP2 and anti-CUZD1, respectively. Positivity for anti-pancreatic autoantibodies predicted a faster progression towards complicated disease course.
Title: Rediscovery of the Anti-Pancreatic Antibodies and Evaluation of their Prognostic Value in a Prospective Clinical Cohort of Crohn's Patients: The Importance of Specific Target Antigens [GP2 and CUZD1].

CUZD1 appears to be one of the relatively few biomarkers that serve as both cancer biomarker and autoantigen of autoantibodies in an autoimmune disease unrelated to cancerous organs. (Review)
Title: CUZD1 and anti-CUZD1 antibodies as markers of cancer and inflammatory bowel diseases.

CUZD1 appears to be a highly promising novel serum biomarker for ovarian cancer diagnosis.
Title: CUB and zona pellucida-like domain-containing protein 1 (CUZD1): a novel serological biomarker for ovarian cancer.

human UO-44 gene expression may prove to be valuable pretreatment targets for antitumor therapy
Title: Silencing expression of UO-44 (CUZD1) using small interfering RNA sensitizes human ovarian cancer cells to cisplatin in vitro.

The following CUZD1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CUZD1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu07791	NM_022034.6 Latest version!	Homo sapiens CUB and zona pellucida like domains 1 (CUZD1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
View Old Accession Versions >>
OHu07791	NM_022034.5	Homo sapiens CUB and zona pellucida like domains 1 (CUZD1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CUZD1 ( NM_022034.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_071317.2 Homo sapiens CUB and zona pellucida like domains 1 (CUZD1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu07791
Clone ID Related Accession (Same CDS sequence)	NM_022034.5 , NM_022034.6
Accession Version	NM_022034.5	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1824bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	CUB and zona pellucida-like domain-containing protein 1 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AY260047.1 and AL359747.14. On Feb 25, 2011 this sequence version replaced NM_022034.4. Transcript Variant: This variant (1), also known as UO-44D, represents the longer transcript and encodes the supported protein. ##Evidence-Data-START## Transcript exon combination :: AY260047.1, SRR1660809.253342.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAGCTTG TAAGAAGGCT CATGCCATTG ACCCTCTTAA TTCTCTCCTG TTTGGCGGAG 
CTGACAATGG CGGAGGCTGA AGGCAATGCA AGCTGCACAG TCAGTCTAGG GGGTGCCAAT 
ATGGCAGAGA CCCACAAAGC CATGATCCTG CAACTCAATC CCAGTGAGAA CTGCACCTGG 
ACAATAGAAA GACCAGAAAA CAAAAGCATC AGAATTATCT TTTCCTATGT CCAGCTTGAT 
CCAGATGGAA GCTGTGAAAG TGAAAACATT AAAGTCTTTG ACGGAACCTC CAGCAATGGG 
CCTCTGCTAG GGCAAGTCTG CAGTAAAAAC GACTATGTTC CTGTATTTGA ATCATCATCC 
AGTACATTGA CGTTTCAAAT AGTTACTGAC TCAGCAAGAA TTCAAAGAAC TGTCTTTGTC 
TTCTACTACT TCTTCTCTCC TAACATCTCT ATTCCAAACT GTGGCGGTTA CCTGGATACC 
TTGGAAGGAT CCTTCACCAG CCCCAATTAC CCAAAGCCGC ATCCTGAGCT GGCTTATTGT 
GTGTGGCACA TACAAGTGGA GAAAGATTAC AAGATAAAAC TAAACTTCAA AGAGATTTTC 
CTAGAAATAG ACAAACAGTG CAAATTTGAT TTTCTTGCCA TCTATGATGG CCCCTCCACC 
AACTCTGGCC TGATTGGACA AGTCTGTGGC CGTGTGACTC CCACCTTCGA ATCGTCATCA 
AACTCTCTGA CTGTCGTGTT GTCTACAGAT TATGCCAATT CTTACCGGGG ATTTTCTGCT 
TCCTACACCT CAATTTATGC AGAAAACATC AACACTACAT CTTTAACTTG CTCTTCTGAC 
AGGATGAGAG TTATTATAAG CAAATCCTAC CTAGAGGCTT TTAACTCTAA TGGGAATAAC 
TTGCAACTAA AAGACCCAAC TTGCAGACCA AAATTATCAA ATGTTGTGGA ATTTTCTGTC 
CCTCTTAATG GATGTGGTAC AATCAGAAAG GTAGAAGATC AGTCAATTAC TTACACCAAT 
ATAATCACCT TTTCTGCATC CTCAACTTCT GAAGTGATCA CCCGTCAGAA ACAACTCCAG 
ATTATTGTGA AGTGTGAAAT GGGACATAAT TCTACAGTGG AGATAATATA CATAACAGAA 
GATGATGTAA TACAAAGTCA AAATGCACTG GGCAAATATA ACACCAGCAT GGCTCTTTTT 
GAATCCAATT CATTTGAAAA GACTATACTT GAATCACCAT ATTATGTGGA TTTGAACCAA 
ACTCTTTTTG TTCAAGTTAG TCTGCACACC TCAGATCCAA ATTTGGTGGT GTTTCTTGAT 
ACCTGTAGAG CCTCTCCCAC CTCTGACTTT GCATCTCCAA CCTACGACCT AATCAAGAGT 
GGATGTAGTC GAGATGAAAC TTGTAAGGTG TATCCCTTAT TTGGACACTA TGGGAGATTC 
CAGTTTAATG CCTTTAAATT CTTGAGAAGT ATGAGCTCTG TGTATCTGCA GTGTAAAGTT 
TTGATATGTG ATAGCAGTGA CCACCAGTCT CGCTGCAATC AAGGTTGTGT CTCCAGAAGC 
AAACGAGACA TTTCTTCATA TAAATGGAAA ACAGATTCCA TCATAGGACC CATTCGTCTG 
AAAAGGGATC GAAGTGCAAG TGGCAATTCA GGATTTCAGC ATGAAACACA TGCGGAAGAA 
ACTCCAAACC AGCCTTTCAA CAGTGTGCAT CTGTTTTCCT TCATGGTTCT AGCTCTGAAT 
GTGGTGACTG TAGCGACAAT CACAGTGAGG CATTTTGTAA ATCAACGGGC AGACTACAAA 
TACCAGAAGC TGCAGAACTA TTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_071317.2
CDS	333..2156
Translation	MELVRRLMPLTLLILSCLAELTMAEAEGNASCTVSLGGANMAETHKAMILQLNPSENCTWTIERPENKSIRIIFSYVQLDPDGSCESENIKVFDGTSSNGPLLGQVCSKNDYVPVFESSSSTLTFQIVTDSARIQRTVFVFYYFFSPNISIPNCGGYLDTLEGSFTSPNYPKPHPELAYCVWHIQVEKDYKIKLNFKEIFLEIDKQCKFDFLAIYDGPSTNSGLIGQVCGRVTPTFESSSNSLTVVLSTDYANSYRGFSASYTSIYAENINTTSLTCSSDRMRVIISKSYLEAFNSNGNNLQLKDPTCRPKLSNVVEFSVPLNGCGTIRKVEDQSITYTNIITFSASSTSEVITRQKQLQIIVKCEMGHNSTVEIIYITEDDVIQSQNALGKYNTSMALFESNSFEKTILESPYYVDLNQTLFVQVSLHTSDPNLVVFLDTCRASPTSDFASPTYDLIKSGCSRDETCKVYPLFGHYGRFQFNAFKFLRSMSSVYLQCKVLICDSSDHQSRCNQGCVSRSKRDISSYKWKTDSIIGPIRLKRDRSASGNSGFQHETHAEETPNQPFNSVHLFSFMVLALNVVTVATITVRHFVNQRADYKYQKLQNY

Target ORF information:

RefSeq Version	NM_022034.5
Organism	Homo sapiens(human)
Definition	Homo sapiens CUB and zona pellucida like domains 1 (CUZD1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_022034.5

ORF Insert Sequence:

ATGGAGCTTG TAAGAAGGCT CATGCCATTG ACCCTCTTAA TTCTCTCCTG TTTGGCGGAG 
CTGACAATGG CGGAGGCTGA AGGCAATGCA AGCTGCACAG TCAGTCTAGG GGGTGCCAAT 
ATGGCAGAGA CCCACAAAGC CATGATCCTG CAACTCAATC CCAGTGAGAA CTGCACCTGG 
ACAATAGAAA GACCAGAAAA CAAAAGCATC AGAATTATCT TTTCCTATGT CCAGCTTGAT 
CCAGATGGAA GCTGTGAAAG TGAAAACATT AAAGTCTTTG ACGGAACCTC CAGCAATGGG 
CCTCTGCTAG GGCAAGTCTG CAGTAAAAAC GACTATGTTC CTGTATTTGA ATCATCATCC 
AGTACATTGA CGTTTCAAAT AGTTACTGAC TCAGCAAGAA TTCAAAGAAC TGTCTTTGTC 
TTCTACTACT TCTTCTCTCC TAACATCTCT ATTCCAAACT GTGGCGGTTA CCTGGATACC 
TTGGAAGGAT CCTTCACCAG CCCCAATTAC CCAAAGCCGC ATCCTGAGCT GGCTTATTGT 
GTGTGGCACA TACAAGTGGA GAAAGATTAC AAGATAAAAC TAAACTTCAA AGAGATTTTC 
CTAGAAATAG ACAAACAGTG CAAATTTGAT TTTCTTGCCA TCTATGATGG CCCCTCCACC 
AACTCTGGCC TGATTGGACA AGTCTGTGGC CGTGTGACTC CCACCTTCGA ATCGTCATCA 
AACTCTCTGA CTGTCGTGTT GTCTACAGAT TATGCCAATT CTTACCGGGG ATTTTCTGCT 
TCCTACACCT CAATTTATGC AGAAAACATC AACACTACAT CTTTAACTTG CTCTTCTGAC 
AGGATGAGAG TTATTATAAG CAAATCCTAC CTAGAGGCTT TTAACTCTAA TGGGAATAAC 
TTGCAACTAA AAGACCCAAC TTGCAGACCA AAATTATCAA ATGTTGTGGA ATTTTCTGTC 
CCTCTTAATG GATGTGGTAC AATCAGAAAG GTAGAAGATC AGTCAATTAC TTACACCAAT 
ATAATCACCT TTTCTGCATC CTCAACTTCT GAAGTGATCA CCCGTCAGAA ACAACTCCAG 
ATTATTGTGA AGTGTGAAAT GGGACATAAT TCTACAGTGG AGATAATATA CATAACAGAA 
GATGATGTAA TACAAAGTCA AAATGCACTG GGCAAATATA ACACCAGCAT GGCTCTTTTT 
GAATCCAATT CATTTGAAAA GACTATACTT GAATCACCAT ATTATGTGGA TTTGAACCAA 
ACTCTTTTTG TTCAAGTTAG TCTGCACACC TCAGATCCAA ATTTGGTGGT GTTTCTTGAT 
ACCTGTAGAG CCTCTCCCAC CTCTGACTTT GCATCTCCAA CCTACGACCT AATCAAGAGT 
GGATGTAGTC GAGATGAAAC TTGTAAGGTG TATCCCTTAT TTGGACACTA TGGGAGATTC 
CAGTTTAATG CCTTTAAATT CTTGAGAAGT ATGAGCTCTG TGTATCTGCA GTGTAAAGTT 
TTGATATGTG ATAGCAGTGA CCACCAGTCT CGCTGCAATC AAGGTTGTGT CTCCAGAAGC 
AAACGAGACA TTTCTTCATA TAAATGGAAA ACAGATTCCA TCATAGGACC CATTCGTCTG 
AAAAGGGATC GAAGTGCAAG TGGCAATTCA GGATTTCAGC ATGAAACACA TGCGGAAGAA 
ACTCCAAACC AGCCTTTCAA CAGTGTGCAT CTGTTTTCCT TCATGGTTCT AGCTCTGAAT 
GTGGTGACTG TAGCGACAAT CACAGTGAGG CATTTTGTAA ATCAACGGGC AGACTACAAA 
TACCAGAAGC TGCAGAACTA TTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CUZD1 ( NM_022034.6 ) cDNA ORF clone, Homo sapiens(human) -> NP_071317.2 Homo sapiens CUB and zona pellucida like domains 1 (CUZD1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu07791
Clone ID Related Accession (Same CDS sequence)	NM_022034.5 , NM_022034.6
Accession Version	NM_022034.6 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1824bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Homo sapiens(human)
Product	CUB and zona pellucida-like domain-containing protein 1 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AY260047.1. On Nov 23, 2018 this sequence version replaced NM_022034.5. Transcript Variant: This variant (1), also known as UO-44D, represents the longer transcript and encodes the supported protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY260047.1, SRR1660809.253342.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000392790.6/ ENSP00000376540.1 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGAGCTTG TAAGAAGGCT CATGCCATTG ACCCTCTTAA TTCTCTCCTG TTTGGCGGAG 
CTGACAATGG CGGAGGCTGA AGGCAATGCA AGCTGCACAG TCAGTCTAGG GGGTGCCAAT 
ATGGCAGAGA CCCACAAAGC CATGATCCTG CAACTCAATC CCAGTGAGAA CTGCACCTGG 
ACAATAGAAA GACCAGAAAA CAAAAGCATC AGAATTATCT TTTCCTATGT CCAGCTTGAT 
CCAGATGGAA GCTGTGAAAG TGAAAACATT AAAGTCTTTG ACGGAACCTC CAGCAATGGG 
CCTCTGCTAG GGCAAGTCTG CAGTAAAAAC GACTATGTTC CTGTATTTGA ATCATCATCC 
AGTACATTGA CGTTTCAAAT AGTTACTGAC TCAGCAAGAA TTCAAAGAAC TGTCTTTGTC 
TTCTACTACT TCTTCTCTCC TAACATCTCT ATTCCAAACT GTGGCGGTTA CCTGGATACC 
TTGGAAGGAT CCTTCACCAG CCCCAATTAC CCAAAGCCGC ATCCTGAGCT GGCTTATTGT 
GTGTGGCACA TACAAGTGGA GAAAGATTAC AAGATAAAAC TAAACTTCAA AGAGATTTTC 
CTAGAAATAG ACAAACAGTG CAAATTTGAT TTTCTTGCCA TCTATGATGG CCCCTCCACC 
AACTCTGGCC TGATTGGACA AGTCTGTGGC CGTGTGACTC CCACCTTCGA ATCGTCATCA 
AACTCTCTGA CTGTCGTGTT GTCTACAGAT TATGCCAATT CTTACCGGGG ATTTTCTGCT 
TCCTACACCT CAATTTATGC AGAAAACATC AACACTACAT CTTTAACTTG CTCTTCTGAC 
AGGATGAGAG TTATTATAAG CAAATCCTAC CTAGAGGCTT TTAACTCTAA TGGGAATAAC 
TTGCAACTAA AAGACCCAAC TTGCAGACCA AAATTATCAA ATGTTGTGGA ATTTTCTGTC 
CCTCTTAATG GATGTGGTAC AATCAGAAAG GTAGAAGATC AGTCAATTAC TTACACCAAT 
ATAATCACCT TTTCTGCATC CTCAACTTCT GAAGTGATCA CCCGTCAGAA ACAACTCCAG 
ATTATTGTGA AGTGTGAAAT GGGACATAAT TCTACAGTGG AGATAATATA CATAACAGAA 
GATGATGTAA TACAAAGTCA AAATGCACTG GGCAAATATA ACACCAGCAT GGCTCTTTTT 
GAATCCAATT CATTTGAAAA GACTATACTT GAATCACCAT ATTATGTGGA TTTGAACCAA 
ACTCTTTTTG TTCAAGTTAG TCTGCACACC TCAGATCCAA ATTTGGTGGT GTTTCTTGAT 
ACCTGTAGAG CCTCTCCCAC CTCTGACTTT GCATCTCCAA CCTACGACCT AATCAAGAGT 
GGATGTAGTC GAGATGAAAC TTGTAAGGTG TATCCCTTAT TTGGACACTA TGGGAGATTC 
CAGTTTAATG CCTTTAAATT CTTGAGAAGT ATGAGCTCTG TGTATCTGCA GTGTAAAGTT 
TTGATATGTG ATAGCAGTGA CCACCAGTCT CGCTGCAATC AAGGTTGTGT CTCCAGAAGC 
AAACGAGACA TTTCTTCATA TAAATGGAAA ACAGATTCCA TCATAGGACC CATTCGTCTG 
AAAAGGGATC GAAGTGCAAG TGGCAATTCA GGATTTCAGC ATGAAACACA TGCGGAAGAA 
ACTCCAAACC AGCCTTTCAA CAGTGTGCAT CTGTTTTCCT TCATGGTTCT AGCTCTGAAT 
GTGGTGACTG TAGCGACAAT CACAGTGAGG CATTTTGTAA ATCAACGGGC AGACTACAAA 
TACCAGAAGC TGCAGAACTA TTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_071317.2
CDS	15..1838
Translation	MELVRRLMPLTLLILSCLAELTMAEAEGNASCTVSLGGANMAETHKAMILQLNPSENCTWTIERPENKSIRIIFSYVQLDPDGSCESENIKVFDGTSSNGPLLGQVCSKNDYVPVFESSSSTLTFQIVTDSARIQRTVFVFYYFFSPNISIPNCGGYLDTLEGSFTSPNYPKPHPELAYCVWHIQVEKDYKIKLNFKEIFLEIDKQCKFDFLAIYDGPSTNSGLIGQVCGRVTPTFESSSNSLTVVLSTDYANSYRGFSASYTSIYAENINTTSLTCSSDRMRVIISKSYLEAFNSNGNNLQLKDPTCRPKLSNVVEFSVPLNGCGTIRKVEDQSITYTNIITFSASSTSEVITRQKQLQIIVKCEMGHNSTVEIIYITEDDVIQSQNALGKYNTSMALFESNSFEKTILESPYYVDLNQTLFVQVSLHTSDPNLVVFLDTCRASPTSDFASPTYDLIKSGCSRDETCKVYPLFGHYGRFQFNAFKFLRSMSSVYLQCKVLICDSSDHQSRCNQGCVSRSKRDISSYKWKTDSIIGPIRLKRDRSASGNSGFQHETHAEETPNQPFNSVHLFSFMVLALNVVTVATITVRHFVNQRADYKYQKLQNY

Target ORF information:

RefSeq Version	NM_022034.6
Organism	Homo sapiens(human)
Definition	Homo sapiens CUB and zona pellucida like domains 1 (CUZD1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_022034.6

ORF Insert Sequence:

ATGGAGCTTG TAAGAAGGCT CATGCCATTG ACCCTCTTAA TTCTCTCCTG TTTGGCGGAG 
CTGACAATGG CGGAGGCTGA AGGCAATGCA AGCTGCACAG TCAGTCTAGG GGGTGCCAAT 
ATGGCAGAGA CCCACAAAGC CATGATCCTG CAACTCAATC CCAGTGAGAA CTGCACCTGG 
ACAATAGAAA GACCAGAAAA CAAAAGCATC AGAATTATCT TTTCCTATGT CCAGCTTGAT 
CCAGATGGAA GCTGTGAAAG TGAAAACATT AAAGTCTTTG ACGGAACCTC CAGCAATGGG 
CCTCTGCTAG GGCAAGTCTG CAGTAAAAAC GACTATGTTC CTGTATTTGA ATCATCATCC 
AGTACATTGA CGTTTCAAAT AGTTACTGAC TCAGCAAGAA TTCAAAGAAC TGTCTTTGTC 
TTCTACTACT TCTTCTCTCC TAACATCTCT ATTCCAAACT GTGGCGGTTA CCTGGATACC 
TTGGAAGGAT CCTTCACCAG CCCCAATTAC CCAAAGCCGC ATCCTGAGCT GGCTTATTGT 
GTGTGGCACA TACAAGTGGA GAAAGATTAC AAGATAAAAC TAAACTTCAA AGAGATTTTC 
CTAGAAATAG ACAAACAGTG CAAATTTGAT TTTCTTGCCA TCTATGATGG CCCCTCCACC 
AACTCTGGCC TGATTGGACA AGTCTGTGGC CGTGTGACTC CCACCTTCGA ATCGTCATCA 
AACTCTCTGA CTGTCGTGTT GTCTACAGAT TATGCCAATT CTTACCGGGG ATTTTCTGCT 
TCCTACACCT CAATTTATGC AGAAAACATC AACACTACAT CTTTAACTTG CTCTTCTGAC 
AGGATGAGAG TTATTATAAG CAAATCCTAC CTAGAGGCTT TTAACTCTAA TGGGAATAAC 
TTGCAACTAA AAGACCCAAC TTGCAGACCA AAATTATCAA ATGTTGTGGA ATTTTCTGTC 
CCTCTTAATG GATGTGGTAC AATCAGAAAG GTAGAAGATC AGTCAATTAC TTACACCAAT 
ATAATCACCT TTTCTGCATC CTCAACTTCT GAAGTGATCA CCCGTCAGAA ACAACTCCAG 
ATTATTGTGA AGTGTGAAAT GGGACATAAT TCTACAGTGG AGATAATATA CATAACAGAA 
GATGATGTAA TACAAAGTCA AAATGCACTG GGCAAATATA ACACCAGCAT GGCTCTTTTT 
GAATCCAATT CATTTGAAAA GACTATACTT GAATCACCAT ATTATGTGGA TTTGAACCAA 
ACTCTTTTTG TTCAAGTTAG TCTGCACACC TCAGATCCAA ATTTGGTGGT GTTTCTTGAT 
ACCTGTAGAG CCTCTCCCAC CTCTGACTTT GCATCTCCAA CCTACGACCT AATCAAGAGT 
GGATGTAGTC GAGATGAAAC TTGTAAGGTG TATCCCTTAT TTGGACACTA TGGGAGATTC 
CAGTTTAATG CCTTTAAATT CTTGAGAAGT ATGAGCTCTG TGTATCTGCA GTGTAAAGTT 
TTGATATGTG ATAGCAGTGA CCACCAGTCT CGCTGCAATC AAGGTTGTGT CTCCAGAAGC 
AAACGAGACA TTTCTTCATA TAAATGGAAA ACAGATTCCA TCATAGGACC CATTCGTCTG 
AAAAGGGATC GAAGTGCAAG TGGCAATTCA GGATTTCAGC ATGAAACACA TGCGGAAGAA 
ACTCCAAACC AGCCTTTCAA CAGTGTGCAT CTGTTTTCCT TCATGGTTCT AGCTCTGAAT 
GTGGTGACTG TAGCGACAAT CACAGTGAGG CATTTTGTAA ATCAACGGGC AGACTACAAA 
TACCAGAAGC TGCAGAACTA TTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Aberrantly high expression of the CUB and zona pellucida-like domain-containing protein 1 (CUZD1) in mammary epithelium leads to breast tumorigenesis.
The Journal of biological chemistry(2018 Jan)
Mapes J,Anandan L,Li Q,Neff A,Clevenger CV,Bagchi IC,Bagchi MK

Generation of monoclonal antibodies and development of an immunofluorometric assay for the detection of CUZD1 in tissues and biological fluids.
Clinical biochemistry50(18)1168-1174(2017 Dec)
Farkona S,Soosaipillai A,Filippou P,Korbakis D,Serra S,R?ckert F,Diamandis EP,Blasutig IM

Rediscovery of the Anti-Pancreatic Antibodies and Evaluation of their Prognostic Value in a Prospective Clinical Cohort of Crohn's Patients: The Importance of Specific Target Antigens [GP2 and CUZD1].
Journal of Crohn's & colitis9(8)659-68(2015 Aug)
Papp M,Sipeki N,Tornai T,Altorjay I,Norman GL,Shums Z,Roggenbuck D,Fechner K,St?cker W,Antal-Szalmas P,Veres G,Lakatos PL

CUZD1 and anti-CUZD1 antibodies as markers of cancer and inflammatory bowel diseases.
Clinical & developmental immunology2013968041(2013)
Liaskos C,Rigopoulou EI,Orfanidou T,Bogdanos DP,Papandreou CN

CUB and zona pellucida-like domain-containing protein 1 (CUZD1): a novel serological biomarker for ovarian cancer.
Clinical biochemistry45(18)1543-6(2012 Dec)
Leung F,Soosaipillai A,Kulasingam V,Diamandis EP

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CUZD1 cDNA ORF clone, Homo sapiens(human)

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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