DEC1 cDNA ORF clone, Homo sapiens(Human)

Gene
Clones
gRNAs

Summary

Gene Symbol	DEC1
Entrez Gene ID	50514
Full Name	deleted in esophageal cancer 1
Synonyms	CTS9
General protein information	Preferred Names deleted in esophageal cancer 1 Names deleted in esophageal cancer 1 candidate tumor suppressor CTS9
Gene Type	protein-coding
Organism	Homo sapiens(Human)
Genome	Chromosome: 9 Map Location: 9q33.1
Summary	The function of this gene is not known. This gene is located in a region commonly deleted in esophageal squamous cell carcinomas. Gene expression is reduced or absent in these carcinomas and thus this is a candidate tumor suppressor gene for esophageal squamous cell carcinomas. [provided by RefSeq, Jul 2008].
Disorder MIM:	604767
Disorder Html:	Esophageal squamous cell carcinoma, 133239 (1)

mRNA and Protein(s)

mRNA	Protein	Name
XM_024447566.1	XP_024303334.1	deleted in esophageal cancer 1 isoform X1
NM_017418.2	NP_059114.1	deleted in esophageal cancer 1
XM_011518753.1	XP_011517055.1	deleted in esophageal cancer 1 isoform X1

Pathways from BioSystems
Gene Ontology
Bibliography

Related articles in PubMed

DEC1 is required for anti-apoptotic activity of gastric cancer cells under hypoxia by promoting Survivin expression.
Jia Y, Hu R, Li P, Zheng Y, Wang Y, Ma X
Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association(2017 Dec)

Discovery of six new susceptibility loci and analysis of pleiotropic effects in leprosy.
Liu H, Irwanto A, Fu X, Yu G, Yu Y, Sun Y, Wang C, Wang Z, Okada Y, Low H, Li Y, Liany H, Chen M, Bao F, Li J, You J, Zhang Q, Liu J, Chu T, Andiappan AK, Wang N, Niu G, Liu D, Yu X, Zhang L, Tian H, Zhou G, Rotzschke O, Chen S, Zhang X, Liu J, Zhang F
Nature genetics47(3)267-71(2015 Mar)

Common genetic variants associated with cognitive performance identified using the proxy-phenotype method.
Rietveld CA, Esko T, Davies G, Pers TH, Turley P, Benyamin B, Chabris CF, Emilsson V, Johnson AD, Lee JJ, de Leeuw C, Marioni RE, Medland SE, Miller MB, Rostapshova O, van der Lee SJ, Vinkhuyzen AA, Amin N, Conley D, Derringer J, van Duijn CM, Fehrmann R, Franke L, Glaeser EL, Hansell NK, Hayward C, Iacono WG, Ibrahim-Verbaas C, Jaddoe V, Karjalainen J, Laibson D, Lichtenstein P, Liewald DC, Magnusson PK, Martin NG, McGue M, McMahon G, Pedersen NL, Pinker S, Porteous DJ, Posthuma D, Rivadeneira F, Smith BH, Starr JM, Tiemeier H, Timpson NJ, Trzaskowski M, Uitterlinden AG, Verhulst FC, Ward ME, Wright MJ, Davey Smith G, Deary IJ, Johannesson M, Plomin R, Visscher PM, Benjamin DJ, Cesarini D, Koellinger PD
Proceedings of the National Academy of Sciences of the United States of America111(38)13790-4(2014 Sep)

Genome-wide association study of survival in patients with pancreatic adenocarcinoma.
Wu C, Kraft P, Stolzenberg-Solomon R, Steplowski E, Brotzman M, Xu M, Mudgal P, Amundadottir L, Arslan AA, Bueno-de-Mesquita HB, Gross M, Helzlsouer K, Jacobs EJ, Kooperberg C, Petersen GM, Zheng W, Albanes D, Boutron-Ruault MC, Buring JE, Canzian F, Cao G, Duell EJ, Elena JW, Gaziano JM, Giovannucci EL, Hallmans G, Hutchinson A, Hunter DJ, Jenab M, Jiang G, Khaw KT, LaCroix A, Li Z, Mendelsohn JB, Panico S, Patel AV, Qian ZR, Riboli E, Sesso H, Shen H, Shu XO, Tjonneland A, Tobias GS, Trichopoulos D, Virtamo J, Visvanathan K, Wactawski-Wende J, Wang C, Yu K, Zeleniuch-Jacquotte A, Chanock S, Hoover R, Hartge P, Fuchs CS, Lin D, Wolpin BM
Gut63(1)152-60(2014 Jan)

Deleted in Esophageal Cancer 1(DEC1) is down-regulated and contributes to migration in head and neck squamous cell carcinoma cell lines.
Kunimoto Y, Nakano S, Kataoka H, Shimada Y, Oshimura M, Kitano H
ORL; journal for oto-rhino-laryngology and its related specialties73(1)17-23(2011)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

This study was performed to test the hypothesis that the SHP gene is a target gene of DEC1. Cotransfection demonstrated that DEC1 repressed the SHP promoter and attenuated the transactivation of the classic circadian activator complex of Clock/Bmal1.
Title: Circadian rhythmicity: A functional connection between differentiated embryonic chondrocyte-1 (DEC1) and small heterodimer partner (SHP).

Dec1 is a prognostic factor for the clinical outcome and a predictive factor for the response to TMZ chemotherapy in patients with glioma.
Title: Dec1 expression predicts prognosis and the response to temozolomide chemotherapy in patients with glioma.

decreases of CES and CYP3A4 expression and enzymatic activities induced by Fluoxetine are through decreasing PXR and increasing DEC1 in HepG2 cells
Title: Fluoxetine reduces CES1, CES2, and CYP3A4 expression through decreasing PXR and increasing DEC1 in HepG2 cells.

DEC1 is down-regulated and tends to contribute to the migration ability of tumor cell lines; H3 K27 trimethylation potentially plays an important role in the regulation of DEC1 expression
Title: Deleted in Esophageal Cancer 1(DEC1) is down-regulated and contributes to migration in head and neck squamous cell carcinoma cell lines.

Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: A novel functional DEC1 promoter polymorphism -249T>C reduces risk of squamous cell carcinoma of the head and neck.

The following DEC1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the DEC1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu26267	NM_017418.2 Latest version!	Homo sapiens deleted in esophageal cancer 1 (DEC1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu26267	XM_011518753.1 Latest version!	Homo sapiens deleted in esophageal cancer 1 (DEC1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

DEC1 ( NM_017418.2 ) cDNA ORF clone, Homo sapiens(Human) -> NP_059114.1 Homo sapiens deleted in esophageal cancer 1 (DEC1), mRNA.

Price & Availability↑

CloneID	OHu26267
Clone ID Related Accession (Same CDS sequence)	NM_017418.2 , XM_011518753.1
Accession Version	NM_017418.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 213bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-10-13
Organism	Homo sapiens(human)
Product	deleted in esophageal cancer 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AB022761.1 and BC107103.1. This sequence is a reference standard in the RefSeqGene project. On Oct 16, 2008 this sequence version replaced NM_017418.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB022761.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA2151119 [ECO:0000350] ##Evidence-Data-END##

ATGACAATGA ATGTTCTGGA GGCTGGGAAG TGGAAGAGCA TTGTGCCAGC ACCTGGTGAG 
GGCCTTCTTG CCGTGTTACA CATGATGGTT TTTACTGATG CCCTGCACAG AGAGAGGTCT 
GTAAAGTGGC AAGCAGGAGT CTGCTACAAT GGAGGAAAGG ATTTTGCTGT ATCTCTTGCC 
AGGCCCAAGG CTGCAGAGGG AATTGCAGAT TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_059114.1
CDS	520..732
Translation	MTMNVLEAGKWKSIVPAPGEGLLAVLHMMVFTDALHRERSVKWQAGVCYNGGKDFAVSLARPKAAEGIAD

Target ORF information:

RefSeq Version	NM_017418.2
Organism	Homo sapiens(human)
Definition	Homo sapiens deleted in esophageal cancer 1 (DEC1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_017418.2

ORF Insert Sequence:

ATGACAATGA ATGTTCTGGA GGCTGGGAAG TGGAAGAGCA TTGTGCCAGC ACCTGGTGAG 
GGCCTTCTTG CCGTGTTACA CATGATGGTT TTTACTGATG CCCTGCACAG AGAGAGGTCT 
GTAAAGTGGC AAGCAGGAGT CTGCTACAAT GGAGGAAAGG ATTTTGCTGT ATCTCTTGCC 
AGGCCCAAGG CTGCAGAGGG AATTGCAGAT TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

DEC1 ( XM_011518753.1 ) cDNA ORF clone, Homo sapiens(Human) -> XP_011517055.1 Homo sapiens deleted in esophageal cancer 1 (DEC1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu26267
Clone ID Related Accession (Same CDS sequence)	NM_017418.2 , XM_011518753.1
Accession Version	XM_011518753.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 213bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-03-11
Organism	Homo sapiens(Human)
Product	deleted in esophageal cancer 1 isoform X1
Comment

ATGACAATGA ATGTTCTGGA GGCTGGGAAG TGGAAGAGCA TTGTGCCAGC ACCTGGTGAG 
GGCCTTCTTG CCGTGTTACA CATGATGGTT TTTACTGATG CCCTGCACAG AGAGAGGTCT 
GTAAAGTGGC AAGCAGGAGT CTGCTACAAT GGAGGAAAGG ATTTTGCTGT ATCTCTTGCC 
AGGCCCAAGG CTGCAGAGGG AATTGCAGAT TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011517055.1
Translation	MTMNVLEAGKWKSIVPAPGEGLLAVLHMMVFTDALHRERSVKWQAGVCYNGGKDFAVSLARPKAAEGIAD

Target ORF information:

RefSeq Version	XM_011518753.1
Organism	Homo sapiens(Human)
Definition	Homo sapiens deleted in esophageal cancer 1 (DEC1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011518753.1

ORF Insert Sequence:

ATGACAATGA ATGTTCTGGA GGCTGGGAAG TGGAAGAGCA TTGTGCCAGC ACCTGGTGAG 
GGCCTTCTTG CCGTGTTACA CATGATGGTT TTTACTGATG CCCTGCACAG AGAGAGGTCT 
GTAAAGTGGC AAGCAGGAGT CTGCTACAAT GGAGGAAAGG ATTTTGCTGT ATCTCTTGCC 
AGGCCCAAGG CTGCAGAGGG AATTGCAGAT TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

DEC1 is required for anti-apoptotic activity of gastric cancer cells under hypoxia by promoting Survivin expression.
Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association(2017 Dec)
Jia Y,Hu R,Li P,Zheng Y,Wang Y,Ma X

Discovery of six new susceptibility loci and analysis of pleiotropic effects in leprosy.
Nature genetics47(3)267-71(2015 Mar)
Liu H,Irwanto A,Fu X,Yu G,Yu Y,Sun Y,Wang C,Wang Z,Okada Y,Low H,Li Y,Liany H,Chen M,Bao F,Li J,You J,Zhang Q,Liu J,Chu T,Andiappan AK,Wang N,Niu G,Liu D,Yu X,Zhang L,Tian H,Zhou G,Rotzschke O,Chen S,Zhang X,Liu J,Zhang F

Common genetic variants associated with cognitive performance identified using the proxy-phenotype method.
Proceedings of the National Academy of Sciences of the United States of America111(38)13790-4(2014 Sep)
Rietveld CA,Esko T,Davies G,Pers TH,Turley P,Benyamin B,Chabris CF,Emilsson V,Johnson AD,Lee JJ,de Leeuw C,Marioni RE,Medland SE,Miller MB,Rostapshova O,van der Lee SJ,Vinkhuyzen AA,Amin N,Conley D,Derringer J,van Duijn CM,Fehrmann R,Franke L,Glaeser EL,Hansell NK,Hayward C,Iacono WG,Ibrahim-Verbaas C,Jaddoe V,Karjalainen J,Laibson D,Lichtenstein P,Liewald DC,Magnusson PK,Martin NG,McGue M,McMahon G,Pedersen NL,Pinker S,Porteous DJ,Posthuma D,Rivadeneira F,Smith BH,Starr JM,Tiemeier H,Timpson NJ,Trzaskowski M,Uitterlinden AG,Verhulst FC,Ward ME,Wright MJ,Davey Smith G,Deary IJ,Johannesson M,Plomin R,Visscher PM,Benjamin DJ,Cesarini D,Koellinger PD

Genome-wide association study of survival in patients with pancreatic adenocarcinoma.
Gut63(1)152-60(2014 Jan)
Wu C,Kraft P,Stolzenberg-Solomon R,Steplowski E,Brotzman M,Xu M,Mudgal P,Amundadottir L,Arslan AA,Bueno-de-Mesquita HB,Gross M,Helzlsouer K,Jacobs EJ,Kooperberg C,Petersen GM,Zheng W,Albanes D,Boutron-Ruault MC,Buring JE,Canzian F,Cao G,Duell EJ,Elena JW,Gaziano JM,Giovannucci EL,Hallmans G,Hutchinson A,Hunter DJ,Jenab M,Jiang G,Khaw KT,LaCroix A,Li Z,Mendelsohn JB,Panico S,Patel AV,Qian ZR,Riboli E,Sesso H,Shen H,Shu XO,Tjonneland A,Tobias GS,Trichopoulos D,Virtamo J,Visvanathan K,Wactawski-Wende J,Wang C,Yu K,Zeleniuch-Jacquotte A,Chanock S,Hoover R,Hartge P,Fuchs CS,Lin D,Wolpin BM

Deleted in Esophageal Cancer 1(DEC1) is down-regulated and contributes to migration in head and neck squamous cell carcinoma cell lines.
ORL; journal for oto-rhino-laryngology and its related specialties73(1)17-23(2011)
Kunimoto Y,Nakano S,Kataoka H,Shimada Y,Oshimura M,Kitano H

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DEC1 cDNA ORF clone, Homo sapiens(Human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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