NOX3 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	NOX3
Entrez Gene ID	50508
Full Name	NADPH oxidase 3
Synonyms	GP91-3,MOX-2
General protein information	Preferred Names NADPH oxidase 3 Names NADPH oxidase 3 NADPH oxidase catalytic subunit-like 3 gp91phox homolog 3 mitogenic oxidase 2
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 6 Map Location: 6q25.3
Summary	This gene encodes a member of the NOX family of NADPH oxidases. These enzymes have the capacity to generate superoxide and other reactive oxygen species (ROS) and transport electrons across the plasma membrane. The ROS generated by family members have been implicated in numerous biological functions including host defense, posttranlational processing of proteins, cellular signaling, regulation of gene expression, and cell differentiation. The protein encoded by this gene is expressed predominantly in the inner ear and is involved in the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the perception of gravity.[provided by RefSeq, May 2009].
Disorder MIM:	607105

mRNA and Protein(s)

mRNA	Protein	Name
NM_015718.2	NP_056533.1	NADPH oxidase 3
NM_015718.3	NP_056533.1	NADPH oxidase 3

Pathways from BioSystems

Homologies

	NOX3	XP_001093827.1
Bos taurus (cattle)	NOX3	NP_001178262.1
Homo sapiens (human)	NOX3	NP_056533.1
Pan troglodytes (chimpanzee)	NOX3	XP_527546.2
Gallus gallus (chicken)	NOX3	XP_004935703.1
Canis lupus familiaris (dog)	NOX3	NP_001095303.1
Mus musculus (house mouse)	Nox3	NP_945196.2
Rattus norvegicus (Norway rat)	Nox3	NP_001004216.1

Gene Ontology
Bibliography

Related articles in PubMed

Rare NOX3 Variants Confer Susceptibility to Agranulocytosis During Thyrostatic Treatment of Graves' Disease.
Plantinga TS, Arts P, Knarren GH, Mulder AH, Wakelkamp IM, Hermus AR, Joosten LA, Netea MG, Bisschop PH, de Herder WW, Beijers HJ, de Bruin IJ, Gilissen C, Veltman JA, Hoischen A, Smit JW, Netea-Maier RT
Clinical pharmacology and therapeutics102(6)1017-1024(2017 Dec)

Oxidant stress regulatory genetic variation in recipients and donors contributes to risk of primary graft dysfunction after lung transplantation.
Cantu E, Shah RJ, Lin W, Daye ZJ, Diamond JM, Suzuki Y, Ellis JH, Borders CF, Andah GA, Beduhn B, Meyer NJ, Ruschefski M, Aplenc R, Feng R, Christie JD,
The Journal of thoracic and cardiovascular surgery149(2)596-602(2015 Feb)

Constitutive NADPH oxidase 4 activity resides in the composition of the B-loop and the penultimate C terminus.
von L?hneysen K, Noack D, Hayes P, Friedman JS, Knaus UG
The Journal of biological chemistry287(12)8737-45(2012 Mar)

Impaired OXPHOS complex III in breast cancer.
Owens KM, Kulawiec M, Desouki MM, Vanniarajan A, Singh KK
PloS one6(8)e23846(2011)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

genetic variants in NOX3 may confer susceptibility to antithyroid drug-induced apoptosis of granulocytes.
Title: Rare NOX3 Variants Confer Susceptibility to Agranulocytosis During Thyrostatic Treatment of Graves' Disease.

In lung transplants, our study highlights a donor-recipient interaction of NOX3 and NFE2L2 that increases the risk of PGD.
Title: Oxidant stress regulatory genetic variation in recipients and donors contributes to risk of primary graft dysfunction after lung transplantation.

Reduced matrigel invasion was mediated by reduced ROS levels coinciding with decreased expression of NADPH oxidase 2, 3, 4 and 5 involved in ROS production.
Title: Impaired OXPHOS complex III in breast cancer.

Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.

palmitate-induced ROS generation and that NOX3-derived ROS may drive palmitate-induced hepatic insulin resistance through JNK and p38(MAPK) pathways.
Title: The effects of palmitate on hepatic insulin resistance are mediated by NADPH Oxidase 3-derived reactive oxygen species through JNK and p38MAPK pathways.

The following NOX3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the NOX3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu22596	NM_015718.3 Latest version!	Homo sapiens NADPH oxidase 3 (NOX3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$239.50-$335.30 $479.00
View Old Accession Versions >>
OHu22596	NM_015718.2	Homo sapiens NADPH oxidase 3 (NOX3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$239.50-$335.30 $479.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

NOX3 ( NM_015718.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_056533.1 Homo sapiens NADPH oxidase 3 (NOX3), mRNA.

Price & Availability↑

CloneID	OHu22596
Clone ID Related Accession (Same CDS sequence)	NM_015718.2 , NM_015718.3
Accession Version	NM_015718.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1707bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-19
Organism	Homo sapiens(human)
Product	NADPH oxidase 3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL031773.1. This sequence is a reference standard in the RefSeqGene project. On May 1, 2009 this sequence version replaced NM_015718.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF190122.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA2142680, SAMEA2144333 [ECO:0000350] ##Evidence-Data-END##

ATGATGGGGT GCTGGATTTT GAATGAGGGT CTCTCCACCA TATTAGTACT CTCATGGCTG 
GGAATAAATT TTTATCTGTT TATTGACACG TTCTACTGGT ATGAAGAGGA GGAGTCTTTC 
CATTACACAC GAGTTATTTT GGGTTCAACA CTGGCTTGGG CACGAGCATC CGCACTGTGC 
CTGAATTTTA ACTGCATGCT AATTCTAATA CCTGTCAGTC GAAACCTTAT TTCATTCATA 
AGAGGAACAA GTATTTGCTG CAGAGGACCG TGGAGGAGGC AATTAGACAA AAACCTCAGA 
TTTCACAAAC TGGTCGCCTA TGGGATAGCT GTTAATGCAA CCATCCACAT CGTGGCGCAT 
TTCTTCAACC TGGAACGCTA CCACTGGAGC CAGTCCGAGG AGGCCCAGGG ACTTCTGGCC 
GCACTTTCCA AGCTGGGCAA CACCCCTAAC GAGAGCTACC TCAACCCTGT CCGGACCTTC 
CCCACAAACA CAACCACTGA ATTGCTAAGG ACAATAGCAG GCGTCACCGG TCTGGTGATC 
TCTCTGGCTT TAGTCTTGAT CATGACCTCG TCAACTGAGT TCATCAGACA GGCCTCCTAT 
GAGTTGTTCT GGTACACACA CCATGTTTTC ATCGTCTTCT TTCTCAGCCT GGCCATCCAT 
GGGACGGGTC GGATTGTTCG AGGCCAAACC CAAGACAGTC TCTCTCTGCA CAACATCACC 
TTCTGTAGAG ACCGCTATGC AGAATGGCAG ACAGTGGCCC AATGCCCCGT GCCTCAATTT 
TCTGGCAAGG AACCCTCGGC TTGGAAATGG ATTTTAGGCC CTGTGGTCTT GTATGCATGT 
GAAAGAATAA TTAGGTTCTG GCGATTTCAA CAAGAAGTTG TCATTACCAA GGTGGTAAGC 
CACCCCTCTG GAGTCCTGGA ACTTCACATG AAAAAGCGTG GCTTTAAAAT GGCGCCAGGG 
CAGTACATCT TGGTGCAGTG CCCAGCCATA TCTTCGCTGG AGTGGCACCC CTTCACCCTT 
ACCTCTGCCC CCCAGGAGGA CTTTTTCAGC GTGCACATCC GGGCAGCAGG AGACTGGACA 
GCAGCGCTAC TGGAGGCCTT TGGGGCAGAG GGACAGGCCC TCCAGGAGCC CTGGAGCCTG 
CCAAGGCTGG CAGTGGACGG GCCCTTTGGA ACTGCCCTGA CAGATGTATT TCACTACCCA 
GTGTGTGTGT GCGTTGCCGC GGGGATCGGA GTCACTCCCT TCGCTGCTCT TCTGAAATCT 
ATATGGTACA AATGCAGTGA GGCACAGACC CCACTGAAGC TGAGCAAGGT GTATTTCTAC 
TGGATTTGCC GGGATGCAAG AGCTTTTGAG TGGTTTGCTG ATCTCTTACT CTCCCTGGAA 
ACACGGATGA GTGAGCAGGG GAAAACTCAC TTTCTGAGTT ATCATATATT TCTTACCGGC 
TGGGATGAAA ATCAGGCTCT TCACATAGCT TTACACTGGG ACGAAAATAC TGACGTGATT 
ACAGGCTTAA AGCAGAAGAC CTTCTATGGG AGGCCCAACT GGAACAATGA GTTCAAGCAG 
ATTGCCTACA ATCACCCCAG CAGCAGTATT GGCGTGTTCT TCTGTGGACC TAAAGCTCTC 
TCGAGGACAC TTCAAAAGAT GTGCCACTTG TATTCATCAG CTGACCCCAG AGGTGTTCAT 
TTCTATTACA ACAAGGAGAG CTTCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_056533.1
CDS	104..1810
Translation	MMGCWILNEGLSTILVLSWLGINFYLFIDTFYWYEEEESFHYTRVILGSTLAWARASALCLNFNCMLILIPVSRNLISFIRGTSICCRGPWRRQLDKNLRFHKLVAYGIAVNATIHIVAHFFNLERYHWSQSEEAQGLLAALSKLGNTPNESYLNPVRTFPTNTTTELLRTIAGVTGLVISLALVLIMTSSTEFIRQASYELFWYTHHVFIVFFLSLAIHGTGRIVRGQTQDSLSLHNITFCRDRYAEWQTVAQCPVPQFSGKEPSAWKWILGPVVLYACERIIRFWRFQQEVVITKVVSHPSGVLELHMKKRGFKMAPGQYILVQCPAISSLEWHPFTLTSAPQEDFFSVHIRAAGDWTAALLEAFGAEGQALQEPWSLPRLAVDGPFGTALTDVFHYPVCVCVAAGIGVTPFAALLKSIWYKCSEAQTPLKLSKVYFYWICRDARAFEWFADLLLSLETRMSEQGKTHFLSYHIFLTGWDENQALHIALHWDENTDVITGLKQKTFYGRPNWNNEFKQIAYNHPSSSIGVFFCGPKALSRTLQKMCHLYSSADPRGVHFYYNKESF

Target ORF information:

RefSeq Version	NM_015718.2
Organism	Homo sapiens(human)
Definition	Homo sapiens NADPH oxidase 3 (NOX3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_015718.2

ORF Insert Sequence:

ATGATGGGGT GCTGGATTTT GAATGAGGGT CTCTCCACCA TATTAGTACT CTCATGGCTG 
GGAATAAATT TTTATCTGTT TATTGACACG TTCTACTGGT ATGAAGAGGA GGAGTCTTTC 
CATTACACAC GAGTTATTTT GGGTTCAACA CTGGCTTGGG CACGAGCATC CGCACTGTGC 
CTGAATTTTA ACTGCATGCT AATTCTAATA CCTGTCAGTC GAAACCTTAT TTCATTCATA 
AGAGGAACAA GTATTTGCTG CAGAGGACCG TGGAGGAGGC AATTAGACAA AAACCTCAGA 
TTTCACAAAC TGGTCGCCTA TGGGATAGCT GTTAATGCAA CCATCCACAT CGTGGCGCAT 
TTCTTCAACC TGGAACGCTA CCACTGGAGC CAGTCCGAGG AGGCCCAGGG ACTTCTGGCC 
GCACTTTCCA AGCTGGGCAA CACCCCTAAC GAGAGCTACC TCAACCCTGT CCGGACCTTC 
CCCACAAACA CAACCACTGA ATTGCTAAGG ACAATAGCAG GCGTCACCGG TCTGGTGATC 
TCTCTGGCTT TAGTCTTGAT CATGACCTCG TCAACTGAGT TCATCAGACA GGCCTCCTAT 
GAGTTGTTCT GGTACACACA CCATGTTTTC ATCGTCTTCT TTCTCAGCCT GGCCATCCAT 
GGGACGGGTC GGATTGTTCG AGGCCAAACC CAAGACAGTC TCTCTCTGCA CAACATCACC 
TTCTGTAGAG ACCGCTATGC AGAATGGCAG ACAGTGGCCC AATGCCCCGT GCCTCAATTT 
TCTGGCAAGG AACCCTCGGC TTGGAAATGG ATTTTAGGCC CTGTGGTCTT GTATGCATGT 
GAAAGAATAA TTAGGTTCTG GCGATTTCAA CAAGAAGTTG TCATTACCAA GGTGGTAAGC 
CACCCCTCTG GAGTCCTGGA ACTTCACATG AAAAAGCGTG GCTTTAAAAT GGCGCCAGGG 
CAGTACATCT TGGTGCAGTG CCCAGCCATA TCTTCGCTGG AGTGGCACCC CTTCACCCTT 
ACCTCTGCCC CCCAGGAGGA CTTTTTCAGC GTGCACATCC GGGCAGCAGG AGACTGGACA 
GCAGCGCTAC TGGAGGCCTT TGGGGCAGAG GGACAGGCCC TCCAGGAGCC CTGGAGCCTG 
CCAAGGCTGG CAGTGGACGG GCCCTTTGGA ACTGCCCTGA CAGATGTATT TCACTACCCA 
GTGTGTGTGT GCGTTGCCGC GGGGATCGGA GTCACTCCCT TCGCTGCTCT TCTGAAATCT 
ATATGGTACA AATGCAGTGA GGCACAGACC CCACTGAAGC TGAGCAAGGT GTATTTCTAC 
TGGATTTGCC GGGATGCAAG AGCTTTTGAG TGGTTTGCTG ATCTCTTACT CTCCCTGGAA 
ACACGGATGA GTGAGCAGGG GAAAACTCAC TTTCTGAGTT ATCATATATT TCTTACCGGC 
TGGGATGAAA ATCAGGCTCT TCACATAGCT TTACACTGGG ACGAAAATAC TGACGTGATT 
ACAGGCTTAA AGCAGAAGAC CTTCTATGGG AGGCCCAACT GGAACAATGA GTTCAAGCAG 
ATTGCCTACA ATCACCCCAG CAGCAGTATT GGCGTGTTCT TCTGTGGACC TAAAGCTCTC 
TCGAGGACAC TTCAAAAGAT GTGCCACTTG TATTCATCAG CTGACCCCAG AGGTGTTCAT 
TTCTATTACA ACAAGGAGAG CTTCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

NOX3 ( NM_015718.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_056533.1 Homo sapiens NADPH oxidase 3 (NOX3), mRNA.

Price & Availability↑

CloneID	OHu22596
Clone ID Related Accession (Same CDS sequence)	NM_015718.2 , NM_015718.3
Accession Version	NM_015718.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1707bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-24
Organism	Homo sapiens(human)
Product	NADPH oxidase 3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL031773.1. This sequence is a reference standard in the RefSeqGene project. On May 17, 2019 this sequence version replaced NM_015718.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF190122.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA2142680, SAMEA2144333 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000159060.3/ ENSP00000159060.2 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##

ATGATGGGGT GCTGGATTTT GAATGAGGGT CTCTCCACCA TATTAGTACT CTCATGGCTG 
GGAATAAATT TTTATCTGTT TATTGACACG TTCTACTGGT ATGAAGAGGA GGAGTCTTTC 
CATTACACAC GAGTTATTTT GGGTTCAACA CTGGCTTGGG CACGAGCATC CGCACTGTGC 
CTGAATTTTA ACTGCATGCT AATTCTAATA CCTGTCAGTC GAAACCTTAT TTCATTCATA 
AGAGGAACAA GTATTTGCTG CAGAGGACCG TGGAGGAGGC AATTAGACAA AAACCTCAGA 
TTTCACAAAC TGGTCGCCTA TGGGATAGCT GTTAATGCAA CCATCCACAT CGTGGCGCAT 
TTCTTCAACC TGGAACGCTA CCACTGGAGC CAGTCCGAGG AGGCCCAGGG ACTTCTGGCC 
GCACTTTCCA AGCTGGGCAA CACCCCTAAC GAGAGCTACC TCAACCCTGT CCGGACCTTC 
CCCACAAACA CAACCACTGA ATTGCTAAGG ACAATAGCAG GCGTCACCGG TCTGGTGATC 
TCTCTGGCTT TAGTCTTGAT CATGACCTCG TCAACTGAGT TCATCAGACA GGCCTCCTAT 
GAGTTGTTCT GGTACACACA CCATGTTTTC ATCGTCTTCT TTCTCAGCCT GGCCATCCAT 
GGGACGGGTC GGATTGTTCG AGGCCAAACC CAAGACAGTC TCTCTCTGCA CAACATCACC 
TTCTGTAGAG ACCGCTATGC AGAATGGCAG ACAGTGGCCC AATGCCCCGT GCCTCAATTT 
TCTGGCAAGG AACCCTCGGC TTGGAAATGG ATTTTAGGCC CTGTGGTCTT GTATGCATGT 
GAAAGAATAA TTAGGTTCTG GCGATTTCAA CAAGAAGTTG TCATTACCAA GGTGGTAAGC 
CACCCCTCTG GAGTCCTGGA ACTTCACATG AAAAAGCGTG GCTTTAAAAT GGCGCCAGGG 
CAGTACATCT TGGTGCAGTG CCCAGCCATA TCTTCGCTGG AGTGGCACCC CTTCACCCTT 
ACCTCTGCCC CCCAGGAGGA CTTTTTCAGC GTGCACATCC GGGCAGCAGG AGACTGGACA 
GCAGCGCTAC TGGAGGCCTT TGGGGCAGAG GGACAGGCCC TCCAGGAGCC CTGGAGCCTG 
CCAAGGCTGG CAGTGGACGG GCCCTTTGGA ACTGCCCTGA CAGATGTATT TCACTACCCA 
GTGTGTGTGT GCGTTGCCGC GGGGATCGGA GTCACTCCCT TCGCTGCTCT TCTGAAATCT 
ATATGGTACA AATGCAGTGA GGCACAGACC CCACTGAAGC TGAGCAAGGT GTATTTCTAC 
TGGATTTGCC GGGATGCAAG AGCTTTTGAG TGGTTTGCTG ATCTCTTACT CTCCCTGGAA 
ACACGGATGA GTGAGCAGGG GAAAACTCAC TTTCTGAGTT ATCATATATT TCTTACCGGC 
TGGGATGAAA ATCAGGCTCT TCACATAGCT TTACACTGGG ACGAAAATAC TGACGTGATT 
ACAGGCTTAA AGCAGAAGAC CTTCTATGGG AGGCCCAACT GGAACAATGA GTTCAAGCAG 
ATTGCCTACA ATCACCCCAG CAGCAGTATT GGCGTGTTCT TCTGTGGACC TAAAGCTCTC 
TCGAGGACAC TTCAAAAGAT GTGCCACTTG TATTCATCAG CTGACCCCAG AGGTGTTCAT 
TTCTATTACA ACAAGGAGAG CTTCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_056533.1
CDS	40..1746
Translation	MMGCWILNEGLSTILVLSWLGINFYLFIDTFYWYEEEESFHYTRVILGSTLAWARASALCLNFNCMLILIPVSRNLISFIRGTSICCRGPWRRQLDKNLRFHKLVAYGIAVNATIHIVAHFFNLERYHWSQSEEAQGLLAALSKLGNTPNESYLNPVRTFPTNTTTELLRTIAGVTGLVISLALVLIMTSSTEFIRQASYELFWYTHHVFIVFFLSLAIHGTGRIVRGQTQDSLSLHNITFCRDRYAEWQTVAQCPVPQFSGKEPSAWKWILGPVVLYACERIIRFWRFQQEVVITKVVSHPSGVLELHMKKRGFKMAPGQYILVQCPAISSLEWHPFTLTSAPQEDFFSVHIRAAGDWTAALLEAFGAEGQALQEPWSLPRLAVDGPFGTALTDVFHYPVCVCVAAGIGVTPFAALLKSIWYKCSEAQTPLKLSKVYFYWICRDARAFEWFADLLLSLETRMSEQGKTHFLSYHIFLTGWDENQALHIALHWDENTDVITGLKQKTFYGRPNWNNEFKQIAYNHPSSSIGVFFCGPKALSRTLQKMCHLYSSADPRGVHFYYNKESF

Target ORF information:

RefSeq Version	NM_015718.3
Organism	Homo sapiens(human)
Definition	Homo sapiens NADPH oxidase 3 (NOX3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_015718.3

ORF Insert Sequence:

ATGATGGGGT GCTGGATTTT GAATGAGGGT CTCTCCACCA TATTAGTACT CTCATGGCTG 
GGAATAAATT TTTATCTGTT TATTGACACG TTCTACTGGT ATGAAGAGGA GGAGTCTTTC 
CATTACACAC GAGTTATTTT GGGTTCAACA CTGGCTTGGG CACGAGCATC CGCACTGTGC 
CTGAATTTTA ACTGCATGCT AATTCTAATA CCTGTCAGTC GAAACCTTAT TTCATTCATA 
AGAGGAACAA GTATTTGCTG CAGAGGACCG TGGAGGAGGC AATTAGACAA AAACCTCAGA 
TTTCACAAAC TGGTCGCCTA TGGGATAGCT GTTAATGCAA CCATCCACAT CGTGGCGCAT 
TTCTTCAACC TGGAACGCTA CCACTGGAGC CAGTCCGAGG AGGCCCAGGG ACTTCTGGCC 
GCACTTTCCA AGCTGGGCAA CACCCCTAAC GAGAGCTACC TCAACCCTGT CCGGACCTTC 
CCCACAAACA CAACCACTGA ATTGCTAAGG ACAATAGCAG GCGTCACCGG TCTGGTGATC 
TCTCTGGCTT TAGTCTTGAT CATGACCTCG TCAACTGAGT TCATCAGACA GGCCTCCTAT 
GAGTTGTTCT GGTACACACA CCATGTTTTC ATCGTCTTCT TTCTCAGCCT GGCCATCCAT 
GGGACGGGTC GGATTGTTCG AGGCCAAACC CAAGACAGTC TCTCTCTGCA CAACATCACC 
TTCTGTAGAG ACCGCTATGC AGAATGGCAG ACAGTGGCCC AATGCCCCGT GCCTCAATTT 
TCTGGCAAGG AACCCTCGGC TTGGAAATGG ATTTTAGGCC CTGTGGTCTT GTATGCATGT 
GAAAGAATAA TTAGGTTCTG GCGATTTCAA CAAGAAGTTG TCATTACCAA GGTGGTAAGC 
CACCCCTCTG GAGTCCTGGA ACTTCACATG AAAAAGCGTG GCTTTAAAAT GGCGCCAGGG 
CAGTACATCT TGGTGCAGTG CCCAGCCATA TCTTCGCTGG AGTGGCACCC CTTCACCCTT 
ACCTCTGCCC CCCAGGAGGA CTTTTTCAGC GTGCACATCC GGGCAGCAGG AGACTGGACA 
GCAGCGCTAC TGGAGGCCTT TGGGGCAGAG GGACAGGCCC TCCAGGAGCC CTGGAGCCTG 
CCAAGGCTGG CAGTGGACGG GCCCTTTGGA ACTGCCCTGA CAGATGTATT TCACTACCCA 
GTGTGTGTGT GCGTTGCCGC GGGGATCGGA GTCACTCCCT TCGCTGCTCT TCTGAAATCT 
ATATGGTACA AATGCAGTGA GGCACAGACC CCACTGAAGC TGAGCAAGGT GTATTTCTAC 
TGGATTTGCC GGGATGCAAG AGCTTTTGAG TGGTTTGCTG ATCTCTTACT CTCCCTGGAA 
ACACGGATGA GTGAGCAGGG GAAAACTCAC TTTCTGAGTT ATCATATATT TCTTACCGGC 
TGGGATGAAA ATCAGGCTCT TCACATAGCT TTACACTGGG ACGAAAATAC TGACGTGATT 
ACAGGCTTAA AGCAGAAGAC CTTCTATGGG AGGCCCAACT GGAACAATGA GTTCAAGCAG 
ATTGCCTACA ATCACCCCAG CAGCAGTATT GGCGTGTTCT TCTGTGGACC TAAAGCTCTC 
TCGAGGACAC TTCAAAAGAT GTGCCACTTG TATTCATCAG CTGACCCCAG AGGTGTTCAT 
TTCTATTACA ACAAGGAGAG CTTCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Rare NOX3 Variants Confer Susceptibility to Agranulocytosis During Thyrostatic Treatment of Graves' Disease.
Clinical pharmacology and therapeutics102(6)1017-1024(2017 Dec)
Plantinga TS,Arts P,Knarren GH,Mulder AH,Wakelkamp IM,Hermus AR,Joosten LA,Netea MG,Bisschop PH,de Herder WW,Beijers HJ,de Bruin IJ,Gilissen C,Veltman JA,Hoischen A,Smit JW,Netea-Maier RT

Oxidant stress regulatory genetic variation in recipients and donors contributes to risk of primary graft dysfunction after lung transplantation.
The Journal of thoracic and cardiovascular surgery149(2)596-602(2015 Feb)
Cantu E,Shah RJ,Lin W,Daye ZJ,Diamond JM,Suzuki Y,Ellis JH,Borders CF,Andah GA,Beduhn B,Meyer NJ,Ruschefski M,Aplenc R,Feng R,Christie JD,

Constitutive NADPH oxidase 4 activity resides in the composition of the B-loop and the penultimate C terminus.
The Journal of biological chemistry287(12)8737-45(2012 Mar)
von L?hneysen K,Noack D,Hayes P,Friedman JS,Knaus UG

Impaired OXPHOS complex III in breast cancer.
PloS one6(8)e23846(2011)
Owens KM,Kulawiec M,Desouki MM,Vanniarajan A,Singh KK

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NOX3 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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