P4HA1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	P4HA1
Entrez Gene ID	5033
Full Name	prolyl 4-hydroxylase subunit alpha 1
Synonyms	P4HA
General protein information	Preferred Names prolyl 4-hydroxylase subunit alpha 1 Names prolyl 4-hydroxylase subunit alpha-1 C-P4Halpha(I) collagen prolyl 4-hydroxylase alpha(I) procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide I procollagen-proline,2-oxoglutarate-4-dioxygenase subunit alpha-1 prolyl 4-hydroxylase, alpha polypeptide I
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 10 Map Location: 10q22.1
Summary	This gene encodes a component of prolyl 4-hydroxylase, a key enzyme in collagen synthesis composed of two identical alpha subunits and two beta subunits. The encoded protein is one of several different types of alpha subunits and provides the major part of the catalytic site of the active enzyme. In collagen and related proteins, prolyl 4-hydroxylase catalyzes the formation of 4-hydroxyproline that is essential to the proper three-dimensional folding of newly synthesized procollagen chains. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008].
Disorder MIM:	176710

mRNA and Protein(s)

mRNA	Protein	Name
NM_000917.3	NP_000908.2	prolyl 4-hydroxylase subunit alpha-1 isoform 1 precursor
NM_001142595.1	NP_001136067.1	prolyl 4-hydroxylase subunit alpha-1 isoform 2 precursor
NM_001142596.1	NP_001136068.1	prolyl 4-hydroxylase subunit alpha-1 isoform 3 precursor
NM_001017962.2	NP_001017962.1	prolyl 4-hydroxylase subunit alpha-1 isoform 2 precursor

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	P4HA1	XP_005619064.1
Bos taurus (cattle)	P4HA1	NP_001069238.1
Danio rerio (zebrafish)	p4ha1a	NP_001038463.1
Drosophila melanogaster (fruit fly)	PH4alphaEFB	NP_733371.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP000971	XP_309164.4
Rattus norvegicus (Norway rat)	P4ha1	NP_742059.2
Caenorhabditis elegans (roundworm)	dpy-18	NP_499464.1
Xenopus tropicalis (tropical clawed frog)	LOC100490484	XP_002936004.1
	P4HA1	XP_001103971.2
Xenopus tropicalis (tropical clawed frog)	p4ha1	XP_004915844.1
Homo sapiens (human)	P4HA1	NP_001136067.1
Mus musculus (house mouse)	P4ha1	NP_035160.1
Danio rerio (zebrafish)	LOC556879	XP_005156147.1
Caenorhabditis elegans (roundworm)	phy-2	NP_502317.1
Pan troglodytes (chimpanzee)	P4HA1	XP_001140652.1
Gallus gallus (chicken)	P4HA1	NP_001185667.1

Gene Ontology
Bibliography

Related articles in PubMed

Identification of P4HA1 as a prognostic biomarker for high-grade gliomas.
Hu WM, Zhang J, Sun SX, Xi SY, Chen ZJ, Jiang XB, Lin FH, Chen ZH, Chen YS, Wang J, Yang QY, Guo CC, Mou YG, Chen ZP, Zeng J, Sai K
Pathology, research and practice213(11)1365-1369(2017 Nov)

P4HA1 mutations cause a unique congenital disorder of connective tissue involving tendon, bone, muscle and the eye.
Zou Y, Donkervoort S, Salo AM, Foley AR, Barnes AM, Hu Y, Makareeva E, Leach ME, Mohassel P, Dastgir J, Deardorff MA, Cohn RD, DiNonno WO, Malfait F, Lek M, Leikin S, Marini JC, Myllyharju J, B?nnemann CG
Human molecular genetics26(12)2207-2217(2017 06)

Knockdown of P4HA1 inhibits neovascularization via targeting glioma stem cell-endothelial cell transdifferentiation and disrupting vascular basement membrane.
Zhou Y, Jin G, Mi R, Zhang J, Zhang J, Xu H, Cheng S, Zhang Y, Song W, Liu F
Oncotarget8(22)35877-35889(2017 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

we report compound heterozygous frameshift and splice site mutations in P4HA1 that impair but not abolish C-P4H alpha(I) activity. The maternal P4HA1 exon 12 splice donor site mutation causes an internally deleted C-P4H alpha(I) predicted to completely lack catalytic activity. two nucleic acid insertion in exon 9 results in a premature stop in the exon 9 P4HA1 splice form.
Title: P4HA1 mutations cause a unique congenital disorder of connective tissue involving tendon, bone, muscle and the eye.

Findings suggest that the catalytic domain of collagen prolyl 4-hydroxylases (CP4Hs) recognizes the cis conformation of the prolyl peptide bond.
Title: Prolyl 4-Hydroxylase: Substrate Isosteres in Which an (E)- or (Z)-Alkene Replaces the Prolyl Peptide Bond.

Thus, we conclude that miR-30e suppresses proliferation of hepatoma cells through targeting P4HA1 mRNA.
Title: MiR-30e suppresses proliferation of hepatoma cells via targeting prolyl 4-hydroxylase subunit alpha-1 (P4HA1) mRNA.

Studies indicate P4HA1 copy number gain in a subset of metastatic prostate tumors and its expression is also regulated by microRNA-124.
Title: The miR-124-prolyl hydroxylase P4HA1-MMP1 axis plays a critical role in prostate cancer progression.

Hypoxia-inducible factor 1 (HIF-1) promotes extracellular matrix remodeling under hypoxic conditions by inducing P4HA1, P4HA2, and PLOD2 expression in fibroblasts.
Title: Hypoxia-inducible factor 1 (HIF-1) promotes extracellular matrix remodeling under hypoxic conditions by inducing P4HA1, P4HA2, and PLOD2 expression in fibroblasts.

The following P4HA1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the P4HA1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu17472	NM_000917.3 Latest version!	Homo sapiens prolyl 4-hydroxylase subunit alpha 1 (P4HA1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$219.50-$307.30 $439.00
OHu17615	NM_001017962.2 Latest version!	Homo sapiens prolyl 4-hydroxylase subunit alpha 1 (P4HA1), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
OHu17615	NM_001142595.1 Latest version!	Homo sapiens prolyl 4-hydroxylase subunit alpha 1 (P4HA1), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
OHu17578	NM_001142596.1 Latest version!	Homo sapiens prolyl 4-hydroxylase subunit alpha 1 (P4HA1), transcript variant 4, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$300.30 $429.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

P4HA1 ( NM_000917.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_000908.2 Homo sapiens prolyl 4-hydroxylase subunit alpha 1 (P4HA1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu17472
Clone ID Related Accession (Same CDS sequence)	NM_000917.3
Accession Version	NM_000917.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1605bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-06-07
Organism	Homo sapiens(human)
Product	prolyl 4-hydroxylase subunit alpha-1 isoform 1 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB030709.1, AK312593.1, CD013930.1 and AI061083.1. On Dec 11, 2008 this sequence version replaced NM_000917.2. Transcript Variant: This variant (1) encodes isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK222960.1, SRR1803611.8534.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: full length.

ATGATCTGGT ATATATTAAT TATAGGAATT CTGCTTCCCC AGTCTTTGGC TCATCCAGGC 
TTTTTTACTT CAATTGGTCA GATGACTGAT TTGATCCATA CTGAGAAAGA TCTGGTGACT 
TCTCTGAAAG ATTATATTAA GGCAGAAGAG GACAAGTTAG AACAAATAAA AAAATGGGCA 
GAGAAGTTAG ATCGGCTAAC TAGTACAGCG ACAAAAGATC CAGAAGGATT TGTTGGGCAT 
CCAGTAAATG CATTCAAATT AATGAAACGT CTGAATACTG AGTGGAGTGA GTTGGAGAAT 
CTGGTCCTTA AGGATATGTC AGATGGCTTT ATCTCTAACC TAACCATTCA GAGACAGTAC 
TTTCCTAATG ATGAAGATCA GGTTGGGGCA GCCAAAGCTC TGTTACGTCT CCAGGATACC 
TACAATTTGG ATACAGATAC CATCTCAAAG GGTAATCTTC CAGGAGTGAA ACACAAATCT 
TTTCTAACGG CTGAGGACTG CTTTGAGTTG GGCAAAGTGG CCTATACAGA AGCAGATTAT 
TACCATACGG AACTGTGGAT GGAACAAGCC CTAAGGCAAC TGGATGAAGG CGAGATTTCT 
ACCATAGATA AAGTCTCTGT TCTAGATTAT TTGAGCTATG CGGTATATCA GCAGGGAGAC 
CTGGATAAGG CACTTTTGCT CACAAAGAAG CTTCTTGAAC TAGATCCTGA ACATCAGAGA 
GCTAATGGTA ACTTAAAATA TTTTGAGTAT ATAATGGCTA AAGAAAAAGA TGTCAATAAG 
TCTGCTTCAG ATGACCAATC TGATCAGAAA ACTACACCAA AGAAAAAAGG GGTTGCTGTG 
GATTACCTGC CAGAGAGACA GAAGTACGAA ATGCTGTGCC GTGGGGAGGG TATCAAAATG 
ACCCCTCGGA GACAGAAAAA ACTCTTTTGC CGCTACCATG ATGGAAACCG TAATCCTAAA 
TTTATTCTGG CTCCAGCTAA ACAGGAGGAT GAATGGGACA AGCCTCGTAT TATTCGCTTC 
CATGATATTA TTTCTGATGC AGAAATTGAA ATCGTCAAAG ACCTAGCAAA ACCAAGGCTG 
AGCCGAGCTA CAGTACATGA CCCTGAGACT GGAAAATTGA CCACAGCACA GTACAGAGTA 
TCTAAGAGTG CCTGGCTCTC TGGCTATGAA AATCCTGTGG TGTCTCGAAT TAATATGAGA 
ATACAAGATC TAACAGGACT AGATGTTTCC ACAGCAGAGG AATTACAGGT AGCAAATTAT 
GGAGTTGGAG GACAGTATGA ACCCCATTTT GACTTTGCAC GGAAAGATGA GCCAGATGCT 
TTCAAAGAGC TGGGGACAGG AAATAGAATT GCTACATGGC TGTTTTATAT GAGTGATGTG 
TCTGCAGGAG GAGCCACTGT TTTTCCTGAA GTTGGAGCTA GTGTTTGGCC CAAAAAAGGA 
ACTGCTGTTT TCTGGTATAA TCTGTTTGCC AGTGGAGAAG GAGATTATAG TACACGGCAT 
GCAGCCTGTC CAGTGCTAGT TGGCAACAAA TGGGTATCCA ATAAATGGCT CCATGAACGT 
GGACAAGAAT TTCGAAGACC TTGTACGTTG TCAGAATTGG AATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000908.2
CDS	242..1846
Translation	MIWYILIIGILLPQSLAHPGFFTSIGQMTDLIHTEKDLVTSLKDYIKAEEDKLEQIKKWAEKLDRLTSTATKDPEGFVGHPVNAFKLMKRLNTEWSELENLVLKDMSDGFISNLTIQRQYFPNDEDQVGAAKALLRLQDTYNLDTDTISKGNLPGVKHKSFLTAEDCFELGKVAYTEADYYHTELWMEQALRQLDEGEISTIDKVSVLDYLSYAVYQQGDLDKALLLTKKLLELDPEHQRANGNLKYFEYIMAKEKDVNKSASDDQSDQKTTPKKKGVAVDYLPERQKYEMLCRGEGIKMTPRRQKKLFCRYHDGNRNPKFILAPAKQEDEWDKPRIIRFHDIISDAEIEIVKDLAKPRLSRATVHDPETGKLTTAQYRVSKSAWLSGYENPVVSRINMRIQDLTGLDVSTAEELQVANYGVGGQYEPHFDFARKDEPDAFKELGTGNRIATWLFYMSDVSAGGATVFPEVGASVWPKKGTAVFWYNLFASGEGDYSTRHAACPVLVGNKWVSNKWLHERGQEFRRPCTLSELE

Target ORF information:

RefSeq Version	NM_000917.3
Organism	Homo sapiens(human)
Definition	Homo sapiens prolyl 4-hydroxylase subunit alpha 1 (P4HA1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000917.3

ORF Insert Sequence:

ATGATCTGGT ATATATTAAT TATAGGAATT CTGCTTCCCC AGTCTTTGGC TCATCCAGGC 
TTTTTTACTT CAATTGGTCA GATGACTGAT TTGATCCATA CTGAGAAAGA TCTGGTGACT 
TCTCTGAAAG ATTATATTAA GGCAGAAGAG GACAAGTTAG AACAAATAAA AAAATGGGCA 
GAGAAGTTAG ATCGGCTAAC TAGTACAGCG ACAAAAGATC CAGAAGGATT TGTTGGGCAT 
CCAGTAAATG CATTCAAATT AATGAAACGT CTGAATACTG AGTGGAGTGA GTTGGAGAAT 
CTGGTCCTTA AGGATATGTC AGATGGCTTT ATCTCTAACC TAACCATTCA GAGACAGTAC 
TTTCCTAATG ATGAAGATCA GGTTGGGGCA GCCAAAGCTC TGTTACGTCT CCAGGATACC 
TACAATTTGG ATACAGATAC CATCTCAAAG GGTAATCTTC CAGGAGTGAA ACACAAATCT 
TTTCTAACGG CTGAGGACTG CTTTGAGTTG GGCAAAGTGG CCTATACAGA AGCAGATTAT 
TACCATACGG AACTGTGGAT GGAACAAGCC CTAAGGCAAC TGGATGAAGG CGAGATTTCT 
ACCATAGATA AAGTCTCTGT TCTAGATTAT TTGAGCTATG CGGTATATCA GCAGGGAGAC 
CTGGATAAGG CACTTTTGCT CACAAAGAAG CTTCTTGAAC TAGATCCTGA ACATCAGAGA 
GCTAATGGTA ACTTAAAATA TTTTGAGTAT ATAATGGCTA AAGAAAAAGA TGTCAATAAG 
TCTGCTTCAG ATGACCAATC TGATCAGAAA ACTACACCAA AGAAAAAAGG GGTTGCTGTG 
GATTACCTGC CAGAGAGACA GAAGTACGAA ATGCTGTGCC GTGGGGAGGG TATCAAAATG 
ACCCCTCGGA GACAGAAAAA ACTCTTTTGC CGCTACCATG ATGGAAACCG TAATCCTAAA 
TTTATTCTGG CTCCAGCTAA ACAGGAGGAT GAATGGGACA AGCCTCGTAT TATTCGCTTC 
CATGATATTA TTTCTGATGC AGAAATTGAA ATCGTCAAAG ACCTAGCAAA ACCAAGGCTG 
AGCCGAGCTA CAGTACATGA CCCTGAGACT GGAAAATTGA CCACAGCACA GTACAGAGTA 
TCTAAGAGTG CCTGGCTCTC TGGCTATGAA AATCCTGTGG TGTCTCGAAT TAATATGAGA 
ATACAAGATC TAACAGGACT AGATGTTTCC ACAGCAGAGG AATTACAGGT AGCAAATTAT 
GGAGTTGGAG GACAGTATGA ACCCCATTTT GACTTTGCAC GGAAAGATGA GCCAGATGCT 
TTCAAAGAGC TGGGGACAGG AAATAGAATT GCTACATGGC TGTTTTATAT GAGTGATGTG 
TCTGCAGGAG GAGCCACTGT TTTTCCTGAA GTTGGAGCTA GTGTTTGGCC CAAAAAAGGA 
ACTGCTGTTT TCTGGTATAA TCTGTTTGCC AGTGGAGAAG GAGATTATAG TACACGGCAT 
GCAGCCTGTC CAGTGCTAGT TGGCAACAAA TGGGTATCCA ATAAATGGCT CCATGAACGT 
GGACAAGAAT TTCGAAGACC TTGTACGTTG TCAGAATTGG AATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

P4HA1 ( NM_001142595.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001136067.1 Homo sapiens prolyl 4-hydroxylase subunit alpha 1 (P4HA1), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu17615
Clone ID Related Accession (Same CDS sequence)	NM_001142595.1 , NM_001017962.2
Accession Version	NM_001142595.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1605bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-06-07
Organism	Homo sapiens(human)
Product	prolyl 4-hydroxylase subunit alpha-1 isoform 2 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB030709.1, CD013930.1 and AI061083.1. Transcript Variant: This variant (3) differs in the 5' UTR and contains an alternate in-frame exon, compared to variant 1. It encodes isoform 2, which is the same length as isoform 1. Variants 2 and 3 both encode isoform 2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803612.17634.1, CD013930.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: full length.

ATGATCTGGT ATATATTAAT TATAGGAATT CTGCTTCCCC AGTCTTTGGC TCATCCAGGC 
TTTTTTACTT CAATTGGTCA GATGACTGAT TTGATCCATA CTGAGAAAGA TCTGGTGACT 
TCTCTGAAAG ATTATATTAA GGCAGAAGAG GACAAGTTAG AACAAATAAA AAAATGGGCA 
GAGAAGTTAG ATCGGCTAAC TAGTACAGCG ACAAAAGATC CAGAAGGATT TGTTGGGCAT 
CCAGTAAATG CATTCAAATT AATGAAACGT CTGAATACTG AGTGGAGTGA GTTGGAGAAT 
CTGGTCCTTA AGGATATGTC AGATGGCTTT ATCTCTAACC TAACCATTCA GAGACAGTAC 
TTTCCTAATG ATGAAGATCA GGTTGGGGCA GCCAAAGCTC TGTTACGTCT CCAGGATACC 
TACAATTTGG ATACAGATAC CATCTCAAAG GGTAATCTTC CAGGAGTGAA ACACAAATCT 
TTTCTAACGG CTGAGGACTG CTTTGAGTTG GGCAAAGTGG CCTATACAGA AGCAGATTAT 
TACCATACGG AACTGTGGAT GGAACAAGCC CTAAGGCAAC TGGATGAAGG CGAGATTTCT 
ACCATAGATA AAGTCTCTGT TCTAGATTAT TTGAGCTATG CGGTATATCA GCAGGGAGAC 
CTGGATAAGG CACTTTTGCT CACAAAGAAG CTTCTTGAAC TAGATCCTGA ACATCAGAGA 
GCTAATGGTA ACTTAAAATA TTTTGAGTAT ATAATGGCTA AAGAAAAAGA TGTCAATAAG 
TCTGCTTCAG ATGACCAATC TGATCAGAAA ACTACACCAA AGAAAAAAGG GGTTGCTGTG 
GATTACCTGC CAGAGAGACA GAAGTACGAA ATGCTGTGCC GTGGGGAGGG TATCAAAATG 
ACCCCTCGGA GACAGAAAAA ACTCTTTTGC CGCTACCATG ATGGAAACCG TAATCCTAAA 
TTTATTCTGG CTCCAGCTAA ACAGGAGGAT GAATGGGACA AGCCTCGTAT TATTCGCTTC 
CATGATATTA TTTCTGATGC AGAAATTGAA ATCGTCAAAG ACCTAGCAAA ACCAAGGCTG 
AGGCGAGCCA CCATTTCAAA CCCAATAACA GGAGACTTGG AGACGGTACA TTACAGAATT 
AGCAAAAGTG CCTGGCTCTC TGGCTATGAA AATCCTGTGG TGTCTCGAAT TAATATGAGA 
ATACAAGATC TAACAGGACT AGATGTTTCC ACAGCAGAGG AATTACAGGT AGCAAATTAT 
GGAGTTGGAG GACAGTATGA ACCCCATTTT GACTTTGCAC GGAAAGATGA GCCAGATGCT 
TTCAAAGAGC TGGGGACAGG AAATAGAATT GCTACATGGC TGTTTTATAT GAGTGATGTG 
TCTGCAGGAG GAGCCACTGT TTTTCCTGAA GTTGGAGCTA GTGTTTGGCC CAAAAAAGGA 
ACTGCTGTTT TCTGGTATAA TCTGTTTGCC AGTGGAGAAG GAGATTATAG TACACGGCAT 
GCAGCCTGTC CAGTGCTAGT TGGCAACAAA TGGGTATCCA ATAAATGGCT CCATGAACGT 
GGACAAGAAT TTCGAAGACC TTGTACGTTG TCAGAATTGG AATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001136067.1
CDS	335..1939
Translation	MIWYILIIGILLPQSLAHPGFFTSIGQMTDLIHTEKDLVTSLKDYIKAEEDKLEQIKKWAEKLDRLTSTATKDPEGFVGHPVNAFKLMKRLNTEWSELENLVLKDMSDGFISNLTIQRQYFPNDEDQVGAAKALLRLQDTYNLDTDTISKGNLPGVKHKSFLTAEDCFELGKVAYTEADYYHTELWMEQALRQLDEGEISTIDKVSVLDYLSYAVYQQGDLDKALLLTKKLLELDPEHQRANGNLKYFEYIMAKEKDVNKSASDDQSDQKTTPKKKGVAVDYLPERQKYEMLCRGEGIKMTPRRQKKLFCRYHDGNRNPKFILAPAKQEDEWDKPRIIRFHDIISDAEIEIVKDLAKPRLRRATISNPITGDLETVHYRISKSAWLSGYENPVVSRINMRIQDLTGLDVSTAEELQVANYGVGGQYEPHFDFARKDEPDAFKELGTGNRIATWLFYMSDVSAGGATVFPEVGASVWPKKGTAVFWYNLFASGEGDYSTRHAACPVLVGNKWVSNKWLHERGQEFRRPCTLSELE

Target ORF information:

RefSeq Version	NM_001142595.1
Organism	Homo sapiens(human)
Definition	Homo sapiens prolyl 4-hydroxylase subunit alpha 1 (P4HA1), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001142595.1

ORF Insert Sequence:

ATGATCTGGT ATATATTAAT TATAGGAATT CTGCTTCCCC AGTCTTTGGC TCATCCAGGC 
TTTTTTACTT CAATTGGTCA GATGACTGAT TTGATCCATA CTGAGAAAGA TCTGGTGACT 
TCTCTGAAAG ATTATATTAA GGCAGAAGAG GACAAGTTAG AACAAATAAA AAAATGGGCA 
GAGAAGTTAG ATCGGCTAAC TAGTACAGCG ACAAAAGATC CAGAAGGATT TGTTGGGCAT 
CCAGTAAATG CATTCAAATT AATGAAACGT CTGAATACTG AGTGGAGTGA GTTGGAGAAT 
CTGGTCCTTA AGGATATGTC AGATGGCTTT ATCTCTAACC TAACCATTCA GAGACAGTAC 
TTTCCTAATG ATGAAGATCA GGTTGGGGCA GCCAAAGCTC TGTTACGTCT CCAGGATACC 
TACAATTTGG ATACAGATAC CATCTCAAAG GGTAATCTTC CAGGAGTGAA ACACAAATCT 
TTTCTAACGG CTGAGGACTG CTTTGAGTTG GGCAAAGTGG CCTATACAGA AGCAGATTAT 
TACCATACGG AACTGTGGAT GGAACAAGCC CTAAGGCAAC TGGATGAAGG CGAGATTTCT 
ACCATAGATA AAGTCTCTGT TCTAGATTAT TTGAGCTATG CGGTATATCA GCAGGGAGAC 
CTGGATAAGG CACTTTTGCT CACAAAGAAG CTTCTTGAAC TAGATCCTGA ACATCAGAGA 
GCTAATGGTA ACTTAAAATA TTTTGAGTAT ATAATGGCTA AAGAAAAAGA TGTCAATAAG 
TCTGCTTCAG ATGACCAATC TGATCAGAAA ACTACACCAA AGAAAAAAGG GGTTGCTGTG 
GATTACCTGC CAGAGAGACA GAAGTACGAA ATGCTGTGCC GTGGGGAGGG TATCAAAATG 
ACCCCTCGGA GACAGAAAAA ACTCTTTTGC CGCTACCATG ATGGAAACCG TAATCCTAAA 
TTTATTCTGG CTCCAGCTAA ACAGGAGGAT GAATGGGACA AGCCTCGTAT TATTCGCTTC 
CATGATATTA TTTCTGATGC AGAAATTGAA ATCGTCAAAG ACCTAGCAAA ACCAAGGCTG 
AGGCGAGCCA CCATTTCAAA CCCAATAACA GGAGACTTGG AGACGGTACA TTACAGAATT 
AGCAAAAGTG CCTGGCTCTC TGGCTATGAA AATCCTGTGG TGTCTCGAAT TAATATGAGA 
ATACAAGATC TAACAGGACT AGATGTTTCC ACAGCAGAGG AATTACAGGT AGCAAATTAT 
GGAGTTGGAG GACAGTATGA ACCCCATTTT GACTTTGCAC GGAAAGATGA GCCAGATGCT 
TTCAAAGAGC TGGGGACAGG AAATAGAATT GCTACATGGC TGTTTTATAT GAGTGATGTG 
TCTGCAGGAG GAGCCACTGT TTTTCCTGAA GTTGGAGCTA GTGTTTGGCC CAAAAAAGGA 
ACTGCTGTTT TCTGGTATAA TCTGTTTGCC AGTGGAGAAG GAGATTATAG TACACGGCAT 
GCAGCCTGTC CAGTGCTAGT TGGCAACAAA TGGGTATCCA ATAAATGGCT CCATGAACGT 
GGACAAGAAT TTCGAAGACC TTGTACGTTG TCAGAATTGG AATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

P4HA1 ( NM_001017962.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001017962.1 Homo sapiens prolyl 4-hydroxylase subunit alpha 1 (P4HA1), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu17615
Clone ID Related Accession (Same CDS sequence)	NM_001142595.1 , NM_001017962.2
Accession Version	NM_001017962.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1605bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Homo sapiens(human)
Product	prolyl 4-hydroxylase subunit alpha-1 isoform 2 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB030709.1, BC034998.1 and AI061083.1. On Dec 11, 2008 this sequence version replaced NM_001017962.1. Transcript Variant: This variant (2) contains an alternate in-frame exon, compared to variant 1. It encodes isoform 2, which is the same length as isoform 1. Variants 2 and 3 both encode isoform 2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC034998.1, SRR1803617.261095.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGATCTGGT ATATATTAAT TATAGGAATT CTGCTTCCCC AGTCTTTGGC TCATCCAGGC 
TTTTTTACTT CAATTGGTCA GATGACTGAT TTGATCCATA CTGAGAAAGA TCTGGTGACT 
TCTCTGAAAG ATTATATTAA GGCAGAAGAG GACAAGTTAG AACAAATAAA AAAATGGGCA 
GAGAAGTTAG ATCGGCTAAC TAGTACAGCG ACAAAAGATC CAGAAGGATT TGTTGGGCAT 
CCAGTAAATG CATTCAAATT AATGAAACGT CTGAATACTG AGTGGAGTGA GTTGGAGAAT 
CTGGTCCTTA AGGATATGTC AGATGGCTTT ATCTCTAACC TAACCATTCA GAGACAGTAC 
TTTCCTAATG ATGAAGATCA GGTTGGGGCA GCCAAAGCTC TGTTACGTCT CCAGGATACC 
TACAATTTGG ATACAGATAC CATCTCAAAG GGTAATCTTC CAGGAGTGAA ACACAAATCT 
TTTCTAACGG CTGAGGACTG CTTTGAGTTG GGCAAAGTGG CCTATACAGA AGCAGATTAT 
TACCATACGG AACTGTGGAT GGAACAAGCC CTAAGGCAAC TGGATGAAGG CGAGATTTCT 
ACCATAGATA AAGTCTCTGT TCTAGATTAT TTGAGCTATG CGGTATATCA GCAGGGAGAC 
CTGGATAAGG CACTTTTGCT CACAAAGAAG CTTCTTGAAC TAGATCCTGA ACATCAGAGA 
GCTAATGGTA ACTTAAAATA TTTTGAGTAT ATAATGGCTA AAGAAAAAGA TGTCAATAAG 
TCTGCTTCAG ATGACCAATC TGATCAGAAA ACTACACCAA AGAAAAAAGG GGTTGCTGTG 
GATTACCTGC CAGAGAGACA GAAGTACGAA ATGCTGTGCC GTGGGGAGGG TATCAAAATG 
ACCCCTCGGA GACAGAAAAA ACTCTTTTGC CGCTACCATG ATGGAAACCG TAATCCTAAA 
TTTATTCTGG CTCCAGCTAA ACAGGAGGAT GAATGGGACA AGCCTCGTAT TATTCGCTTC 
CATGATATTA TTTCTGATGC AGAAATTGAA ATCGTCAAAG ACCTAGCAAA ACCAAGGCTG 
AGGCGAGCCA CCATTTCAAA CCCAATAACA GGAGACTTGG AGACGGTACA TTACAGAATT 
AGCAAAAGTG CCTGGCTCTC TGGCTATGAA AATCCTGTGG TGTCTCGAAT TAATATGAGA 
ATACAAGATC TAACAGGACT AGATGTTTCC ACAGCAGAGG AATTACAGGT AGCAAATTAT 
GGAGTTGGAG GACAGTATGA ACCCCATTTT GACTTTGCAC GGAAAGATGA GCCAGATGCT 
TTCAAAGAGC TGGGGACAGG AAATAGAATT GCTACATGGC TGTTTTATAT GAGTGATGTG 
TCTGCAGGAG GAGCCACTGT TTTTCCTGAA GTTGGAGCTA GTGTTTGGCC CAAAAAAGGA 
ACTGCTGTTT TCTGGTATAA TCTGTTTGCC AGTGGAGAAG GAGATTATAG TACACGGCAT 
GCAGCCTGTC CAGTGCTAGT TGGCAACAAA TGGGTATCCA ATAAATGGCT CCATGAACGT 
GGACAAGAAT TTCGAAGACC TTGTACGTTG TCAGAATTGG AATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001017962.1
CDS	242..1846
Translation	MIWYILIIGILLPQSLAHPGFFTSIGQMTDLIHTEKDLVTSLKDYIKAEEDKLEQIKKWAEKLDRLTSTATKDPEGFVGHPVNAFKLMKRLNTEWSELENLVLKDMSDGFISNLTIQRQYFPNDEDQVGAAKALLRLQDTYNLDTDTISKGNLPGVKHKSFLTAEDCFELGKVAYTEADYYHTELWMEQALRQLDEGEISTIDKVSVLDYLSYAVYQQGDLDKALLLTKKLLELDPEHQRANGNLKYFEYIMAKEKDVNKSASDDQSDQKTTPKKKGVAVDYLPERQKYEMLCRGEGIKMTPRRQKKLFCRYHDGNRNPKFILAPAKQEDEWDKPRIIRFHDIISDAEIEIVKDLAKPRLRRATISNPITGDLETVHYRISKSAWLSGYENPVVSRINMRIQDLTGLDVSTAEELQVANYGVGGQYEPHFDFARKDEPDAFKELGTGNRIATWLFYMSDVSAGGATVFPEVGASVWPKKGTAVFWYNLFASGEGDYSTRHAACPVLVGNKWVSNKWLHERGQEFRRPCTLSELE

Target ORF information:

RefSeq Version	NM_001017962.2
Organism	Homo sapiens(human)
Definition	Homo sapiens prolyl 4-hydroxylase subunit alpha 1 (P4HA1), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001017962.2

ORF Insert Sequence:

ATGATCTGGT ATATATTAAT TATAGGAATT CTGCTTCCCC AGTCTTTGGC TCATCCAGGC 
TTTTTTACTT CAATTGGTCA GATGACTGAT TTGATCCATA CTGAGAAAGA TCTGGTGACT 
TCTCTGAAAG ATTATATTAA GGCAGAAGAG GACAAGTTAG AACAAATAAA AAAATGGGCA 
GAGAAGTTAG ATCGGCTAAC TAGTACAGCG ACAAAAGATC CAGAAGGATT TGTTGGGCAT 
CCAGTAAATG CATTCAAATT AATGAAACGT CTGAATACTG AGTGGAGTGA GTTGGAGAAT 
CTGGTCCTTA AGGATATGTC AGATGGCTTT ATCTCTAACC TAACCATTCA GAGACAGTAC 
TTTCCTAATG ATGAAGATCA GGTTGGGGCA GCCAAAGCTC TGTTACGTCT CCAGGATACC 
TACAATTTGG ATACAGATAC CATCTCAAAG GGTAATCTTC CAGGAGTGAA ACACAAATCT 
TTTCTAACGG CTGAGGACTG CTTTGAGTTG GGCAAAGTGG CCTATACAGA AGCAGATTAT 
TACCATACGG AACTGTGGAT GGAACAAGCC CTAAGGCAAC TGGATGAAGG CGAGATTTCT 
ACCATAGATA AAGTCTCTGT TCTAGATTAT TTGAGCTATG CGGTATATCA GCAGGGAGAC 
CTGGATAAGG CACTTTTGCT CACAAAGAAG CTTCTTGAAC TAGATCCTGA ACATCAGAGA 
GCTAATGGTA ACTTAAAATA TTTTGAGTAT ATAATGGCTA AAGAAAAAGA TGTCAATAAG 
TCTGCTTCAG ATGACCAATC TGATCAGAAA ACTACACCAA AGAAAAAAGG GGTTGCTGTG 
GATTACCTGC CAGAGAGACA GAAGTACGAA ATGCTGTGCC GTGGGGAGGG TATCAAAATG 
ACCCCTCGGA GACAGAAAAA ACTCTTTTGC CGCTACCATG ATGGAAACCG TAATCCTAAA 
TTTATTCTGG CTCCAGCTAA ACAGGAGGAT GAATGGGACA AGCCTCGTAT TATTCGCTTC 
CATGATATTA TTTCTGATGC AGAAATTGAA ATCGTCAAAG ACCTAGCAAA ACCAAGGCTG 
AGGCGAGCCA CCATTTCAAA CCCAATAACA GGAGACTTGG AGACGGTACA TTACAGAATT 
AGCAAAAGTG CCTGGCTCTC TGGCTATGAA AATCCTGTGG TGTCTCGAAT TAATATGAGA 
ATACAAGATC TAACAGGACT AGATGTTTCC ACAGCAGAGG AATTACAGGT AGCAAATTAT 
GGAGTTGGAG GACAGTATGA ACCCCATTTT GACTTTGCAC GGAAAGATGA GCCAGATGCT 
TTCAAAGAGC TGGGGACAGG AAATAGAATT GCTACATGGC TGTTTTATAT GAGTGATGTG 
TCTGCAGGAG GAGCCACTGT TTTTCCTGAA GTTGGAGCTA GTGTTTGGCC CAAAAAAGGA 
ACTGCTGTTT TCTGGTATAA TCTGTTTGCC AGTGGAGAAG GAGATTATAG TACACGGCAT 
GCAGCCTGTC CAGTGCTAGT TGGCAACAAA TGGGTATCCA ATAAATGGCT CCATGAACGT 
GGACAAGAAT TTCGAAGACC TTGTACGTTG TCAGAATTGG AATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

P4HA1 ( NM_001142596.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001136068.1 Homo sapiens prolyl 4-hydroxylase subunit alpha 1 (P4HA1), transcript variant 4, mRNA.

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CloneID	OHu17578
Clone ID Related Accession (Same CDS sequence)	NM_001142596.1
Accession Version	NM_001142596.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1551bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-06-06
Organism	Homo sapiens(human)
Product	prolyl 4-hydroxylase subunit alpha-1 isoform 3 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB030709.1, CD013929.1 and AI061083.1. Transcript Variant: This variant (4) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: CD013929.1, SRR1803616.94993.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: full length.

ATGATCTGGT ATATATTAAT TATAGGAATT CTGCTTCCCC AGTCTTTGGC TCATCCAGGC 
TTTTTTACTT CAATTGGTCA GATGACTGAT TTGATCCATA CTGAGAAAGA TCTGGTGACT 
TCTCTGAAAG ATTATATTAA GGCAGAAGAG GACAAGTTAG AACAAATAAA AAAATGGGCA 
GAGAAGTTAG ATCGGCTAAC TAGTACAGCG ACAAAAGATC CAGAAGGATT TGTTGGGCAT 
CCAGTAAATG CATTCAAATT AATGAAACGT CTGAATACTG AGTGGAGTGA GTTGGAGAAT 
CTGGTCCTTA AGGATATGTC AGATGGCTTT ATCTCTAACC TAACCATTCA GAGACAGTAC 
TTTCCTAATG ATGAAGATCA GGTTGGGGCA GCCAAAGCTC TGTTACGTCT CCAGGATACC 
TACAATTTGG ATACAGATAC CATCTCAAAG GGTAATCTTC CAGGAGTGAA ACACAAATCT 
TTTCTAACGG CTGAGGACTG CTTTGAGTTG GGCAAAGTGG CCTATACAGA AGCAGATTAT 
TACCATACGG AACTGTGGAT GGAACAAGCC CTAAGGCAAC TGGATGAAGG CGAGATTTCT 
ACCATAGATA AAGTCTCTGT TCTAGATTAT TTGAGCTATG CGGTATATCA GCAGGGAGAC 
CTGGATAAGG CACTTTTGCT CACAAAGAAG CTTCTTGAAC TAGATCCTGA ACATCAGAGA 
GCTAATGGTA ACTTAAAATA TTTTGAGTAT ATAATGGCTA AAGAAAAAGA TGTCAATAAG 
TCTGCTTCAG ATGACCAATC TGATCAGAAA ACTACACCAA AGAAAAAAGG GGTTGCTGTG 
GATTACCTGC CAGAGAGACA GAAGTACGAA ATGCTGTGCC GTGGGGAGGG TATCAAAATG 
ACCCCTCGGA GACAGAAAAA ACTCTTTTGC CGCTACCATG ATGGAAACCG TAATCCTAAA 
TTTATTCTGG CTCCAGCTAA ACAGGAGGAT GAATGGGACA AGCCTCGTAT TATTCGCTTC 
CATGATATTA TTTCTGATGC AGAAATTGAA ATCGTCAAAG ACCTAGCAAA ACCAAGGCTG 
AGCCGAGCTA CAGTACATGA CCCTGAGACT GGAAAATTGA CCACAGCACA GTACAGAGTA 
TCTAAGAGTG CCTGGCTCTC TGGCTATGAA AATCCTGTGG TGTCTCGAAT TAATATGAGA 
ATACAAGATC TAACAGGACT AGATGTTTCC ACAGCAGAGG AATTACAGAA AGATGAGCCA 
GATGCTTTCA AAGAGCTGGG GACAGGAAAT AGAATTGCTA CATGGCTGTT TTATATGAGT 
GATGTGTCTG CAGGAGGAGC CACTGTTTTT CCTGAAGTTG GAGCTAGTGT TTGGCCCAAA 
AAAGGAACTG CTGTTTTCTG GTATAATCTG TTTGCCAGTG GAGAAGGAGA TTATAGTACA 
CGGCATGCAG CCTGTCCAGT GCTAGTTGGC AACAAATGGG TATCCAATAA ATGGCTCCAT 
GAACGTGGAC AAGAATTTCG AAGACCTTGT ACGTTGTCAG AATTGGAATG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001136068.1
CDS	242..1792
Translation	MIWYILIIGILLPQSLAHPGFFTSIGQMTDLIHTEKDLVTSLKDYIKAEEDKLEQIKKWAEKLDRLTSTATKDPEGFVGHPVNAFKLMKRLNTEWSELENLVLKDMSDGFISNLTIQRQYFPNDEDQVGAAKALLRLQDTYNLDTDTISKGNLPGVKHKSFLTAEDCFELGKVAYTEADYYHTELWMEQALRQLDEGEISTIDKVSVLDYLSYAVYQQGDLDKALLLTKKLLELDPEHQRANGNLKYFEYIMAKEKDVNKSASDDQSDQKTTPKKKGVAVDYLPERQKYEMLCRGEGIKMTPRRQKKLFCRYHDGNRNPKFILAPAKQEDEWDKPRIIRFHDIISDAEIEIVKDLAKPRLSRATVHDPETGKLTTAQYRVSKSAWLSGYENPVVSRINMRIQDLTGLDVSTAEELQKDEPDAFKELGTGNRIATWLFYMSDVSAGGATVFPEVGASVWPKKGTAVFWYNLFASGEGDYSTRHAACPVLVGNKWVSNKWLHERGQEFRRPCTLSELE

Target ORF information:

RefSeq Version	NM_001142596.1
Organism	Homo sapiens(human)
Definition	Homo sapiens prolyl 4-hydroxylase subunit alpha 1 (P4HA1), transcript variant 4, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001142596.1

ORF Insert Sequence:

ATGATCTGGT ATATATTAAT TATAGGAATT CTGCTTCCCC AGTCTTTGGC TCATCCAGGC 
TTTTTTACTT CAATTGGTCA GATGACTGAT TTGATCCATA CTGAGAAAGA TCTGGTGACT 
TCTCTGAAAG ATTATATTAA GGCAGAAGAG GACAAGTTAG AACAAATAAA AAAATGGGCA 
GAGAAGTTAG ATCGGCTAAC TAGTACAGCG ACAAAAGATC CAGAAGGATT TGTTGGGCAT 
CCAGTAAATG CATTCAAATT AATGAAACGT CTGAATACTG AGTGGAGTGA GTTGGAGAAT 
CTGGTCCTTA AGGATATGTC AGATGGCTTT ATCTCTAACC TAACCATTCA GAGACAGTAC 
TTTCCTAATG ATGAAGATCA GGTTGGGGCA GCCAAAGCTC TGTTACGTCT CCAGGATACC 
TACAATTTGG ATACAGATAC CATCTCAAAG GGTAATCTTC CAGGAGTGAA ACACAAATCT 
TTTCTAACGG CTGAGGACTG CTTTGAGTTG GGCAAAGTGG CCTATACAGA AGCAGATTAT 
TACCATACGG AACTGTGGAT GGAACAAGCC CTAAGGCAAC TGGATGAAGG CGAGATTTCT 
ACCATAGATA AAGTCTCTGT TCTAGATTAT TTGAGCTATG CGGTATATCA GCAGGGAGAC 
CTGGATAAGG CACTTTTGCT CACAAAGAAG CTTCTTGAAC TAGATCCTGA ACATCAGAGA 
GCTAATGGTA ACTTAAAATA TTTTGAGTAT ATAATGGCTA AAGAAAAAGA TGTCAATAAG 
TCTGCTTCAG ATGACCAATC TGATCAGAAA ACTACACCAA AGAAAAAAGG GGTTGCTGTG 
GATTACCTGC CAGAGAGACA GAAGTACGAA ATGCTGTGCC GTGGGGAGGG TATCAAAATG 
ACCCCTCGGA GACAGAAAAA ACTCTTTTGC CGCTACCATG ATGGAAACCG TAATCCTAAA 
TTTATTCTGG CTCCAGCTAA ACAGGAGGAT GAATGGGACA AGCCTCGTAT TATTCGCTTC 
CATGATATTA TTTCTGATGC AGAAATTGAA ATCGTCAAAG ACCTAGCAAA ACCAAGGCTG 
AGCCGAGCTA CAGTACATGA CCCTGAGACT GGAAAATTGA CCACAGCACA GTACAGAGTA 
TCTAAGAGTG CCTGGCTCTC TGGCTATGAA AATCCTGTGG TGTCTCGAAT TAATATGAGA 
ATACAAGATC TAACAGGACT AGATGTTTCC ACAGCAGAGG AATTACAGAA AGATGAGCCA 
GATGCTTTCA AAGAGCTGGG GACAGGAAAT AGAATTGCTA CATGGCTGTT TTATATGAGT 
GATGTGTCTG CAGGAGGAGC CACTGTTTTT CCTGAAGTTG GAGCTAGTGT TTGGCCCAAA 
AAAGGAACTG CTGTTTTCTG GTATAATCTG TTTGCCAGTG GAGAAGGAGA TTATAGTACA 
CGGCATGCAG CCTGTCCAGT GCTAGTTGGC AACAAATGGG TATCCAATAA ATGGCTCCAT 
GAACGTGGAC AAGAATTTCG AAGACCTTGT ACGTTGTCAG AATTGGAATG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Identification of P4HA1 as a prognostic biomarker for high-grade gliomas.
Pathology, research and practice213(11)1365-1369(2017 Nov)
Hu WM,Zhang J,Sun SX,Xi SY,Chen ZJ,Jiang XB,Lin FH,Chen ZH,Chen YS,Wang J,Yang QY,Guo CC,Mou YG,Chen ZP,Zeng J,Sai K

P4HA1 mutations cause a unique congenital disorder of connective tissue involving tendon, bone, muscle and the eye.
Human molecular genetics26(12)2207-2217(2017 06)
Zou Y,Donkervoort S,Salo AM,Foley AR,Barnes AM,Hu Y,Makareeva E,Leach ME,Mohassel P,Dastgir J,Deardorff MA,Cohn RD,DiNonno WO,Malfait F,Lek M,Leikin S,Marini JC,Myllyharju J,B?nnemann CG

Knockdown of P4HA1 inhibits neovascularization via targeting glioma stem cell-endothelial cell transdifferentiation and disrupting vascular basement membrane.
Oncotarget8(22)35877-35889(2017 May)
Zhou Y,Jin G,Mi R,Zhang J,Zhang J,Xu H,Cheng S,Zhang Y,Song W,Liu F

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P4HA1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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