P2RY11 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	P2RY11
Entrez Gene ID	5032
Full Name	purinergic receptor P2Y11
Synonyms	P2Y11
General protein information	Preferred Names purinergic receptor P2Y11 Names P2Y purinoceptor 11 purinergic receptor P2Y, G-protein coupled, 11
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 19 Map Location: 19p13.2
Summary	The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is coupled to the stimulation of the phosphoinositide and adenylyl cyclase pathways and behaves as a selective purinoceptor. Naturally occuring read-through transcripts, resulting from intergenic splicing between this gene and an immediately upstream gene (PPAN, encoding peter pan homolog), have been found. The PPAN-P2RY11 read-through mRNA is ubiquitously expressed and encodes a fusion protein that shares identity with each individual gene product. [provided by RefSeq, Jul 2008].
Disorder MIM:	602697

mRNA and Protein(s)

mRNA	Protein	Name
NM_002566.4	NP_002557.2	P2Y purinoceptor 11
NM_002566.5	NP_002557.2	P2Y purinoceptor 11

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	P2RY11	XP_003316153.1
Xenopus tropicalis (tropical clawed frog)	p2ry11	NP_001005433.1
Homo sapiens (human)	P2RY11	NP_002557.2
Canis lupus familiaris (dog)	P2RY11	NP_001191370.1
Danio rerio (zebrafish)	p2ry11	NP_001191383.1
Bos taurus (cattle)	P2RY11	NP_001191378.1

Gene Ontology
Bibliography

Related articles in PubMed

Carcinoma-specific expression of P2Y11 receptor and its contribution in ATP-induced purinergic signalling and cell migration in human hepatocellular carcinoma cells.
Khalid M, Brisson L, Tariq M, Hao Y, Guibon R, Fromont G, Mortadza SAS, Mousawi F, Manzoor S, Roger S, Jiang LH
Oncotarget8(23)37278-37290(2017 Jun)

Rare missense mutations in P2RY11 in narcolepsy with cataplexy.
Degn M, Dauvilliers Y, Dreisig K, Lopez R, Pfister C, Pradervand S, Rahbek Kornum B, Tafti M
Brain : a journal of neurology140(6)1657-1668(2017 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Decreased P2Y11 signaling plays an important role in the development of narcolepsy with cataplexy.
Title: Rare missense mutations in P2RY11 in narcolepsy with cataplexy.

Hypoxia/reoxygenation inhibits P2y11 receptor expression and its immunosuppressive activity in human dendritic cells.
Title: Hypoxia/Reoxygenation Inhibits P2Y11 Receptor Expression and Its Immunosuppressive Activity in Human Dendritic Cells.

Suggest role for LXA4 in stimulating apical ATP secretion via pannexin-1 channels and P2RY11 purinoreceptors activation leading to an airway surface liquid layer height increase and epithelial repair.
Title: Activation of P2RY11 and ATP release by lipoxin A4 restores the airway surface liquid layer and epithelial repair in cystic fibrosis.

the physiological impact of A87T mutation of the P2Y11 receptor derives from detrimental effects on P2Y1-P2Y11 receptor interaction.
Title: Alanine-(87)-threonine polymorphism impairs signaling and internalization of the human P2Y11 receptor, when co-expressed with the P2Y1 receptor.

vesicular exocytosis of ATP and autocrine, positive feedback through P2Y11 receptors is required for the effective activation of macrophages
Title: Autocrine regulation of macrophage activation via exocytosis of ATP and activation of P2Y11 receptor.

The following P2RY11 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the P2RY11 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu03088	NM_002566.5 Latest version!	Homo sapiens purinergic receptor P2Y11 (P2RY11), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
View Old Accession Versions >>
OHu03088	NM_002566.4	Homo sapiens purinergic receptor P2Y11 (P2RY11), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

P2RY11 ( NM_002566.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_002557.2 Homo sapiens purinergic receptor P2Y11 (P2RY11), mRNA.

Price & Availability↑

CloneID	OHu03088
Clone ID Related Accession (Same CDS sequence)	NM_002566.4 , NM_002566.5
Accession Version	NM_002566.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1125bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-30
Organism	Homo sapiens(human)
Product	P2Y purinoceptor 11
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AA310412.1, BC073827.1 and BC009877.2. This sequence is a reference standard in the RefSeqGene project. On Sep 22, 2004 this sequence version replaced NM_002566.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC073827.1, SRR1163657.196814.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCAGCCA ACGTCTCGGG TGCCAAGTCC TGCCCTGCCA ACTTCTTGGC AGCTGCCGAC 
GACAAACTCA GTGGGTTCCA GGGGGACTTC CTGTGGCCCA TACTGGTGGT TGAGTTCCTG 
GTGGCCGTGG CCAGCAATGG CCTGGCCCTG TACCGCTTCA GCATCCGGAA GCAGCGCCCA 
TGGCACCCCG CCGTGGTCTT CTCTGTCCAG CTGGCAGTCA GCGACCTGCT CTGCGCCCTG 
ACGCTGCCCC CGCTGGCCGC CTACCTCTAT CCCCCCAAGC ACTGGCGCTA TGGGGAGGCC 
GCGTGCCGCC TGGAGCGCTT CCTCTTCACC TGCAACCTGC TGGGCAGCGT CATCTTCATC 
ACCTGCATCA GCCTCAACCG CTACCTGGGC ATCGTGCACC CCTTCTTCGC CCGAAGCCAC 
CTGCGACCCA AGCACGCCTG GGCCGTGAGC GCTGCCGGCT GGGTCCTGGC CGCCCTGCTG 
GCCATGCCCA CACTCAGCTT CTCCCACCTG AAGAGGCCGC AGCAGGGGGC GGGCAACTGC 
AGCGTGGCCA GGCCCGAGGC CTGCATCAAG TGTCTGGGGA CAGCAGACCA CGGGCTGGCG 
GCCTACAGAG CGTATAGCCT GGTGCTGGCG GGGTTGGGCT GCGGCCTGCC GCTGCTGCTC 
ACGCTGGCAG CCTACGGCGC CCTCGGGCGG GCCGTGCTAC GCAGCCCAGG CATGACTGTG 
GCCGAGAAGC TGCGTGTGGC AGCGTTGGTG GCCAGTGGTG TGGCCCTCTA CGCCAGCTCC 
TATGTGCCCT ACCACATCAT GCGGGTGCTC AACGTGGATG CTCGGCGGCG CTGGAGCACC 
CGCTGCCCGA GCTTTGCAGA CATAGCCCAG GCCACAGCAG CCCTGGAGCT GGGGCCCTAC 
GTGGGCTACC AGGTGATGCG GGGCCTCATG CCCCTGGCCT TCTGTGTCCA CCCTCTACTC 
TACATGGCCG CAGTGCCCAG CCTGGGCTGC TGCTGCCGAC ACTGCCCCGG CTACAGGGAC 
AGCTGGAACC CAGAGGACGC CAAGAGCACT GGCCAAGCCC TGCCCCTCAA TGCCACAGCC 
GCCCCTAAAC CGTCAGAGCC CCAGTCCCGT GAGCTGAGCC AATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002557.2
CDS	202..1326
Translation	MAANVSGAKSCPANFLAAADDKLSGFQGDFLWPILVVEFLVAVASNGLALYRFSIRKQRPWHPAVVFSVQLAVSDLLCALTLPPLAAYLYPPKHWRYGEAACRLERFLFTCNLLGSVIFITCISLNRYLGIVHPFFARSHLRPKHAWAVSAAGWVLAALLAMPTLSFSHLKRPQQGAGNCSVARPEACIKCLGTADHGLAAYRAYSLVLAGLGCGLPLLLTLAAYGALGRAVLRSPGMTVAEKLRVAALVASGVALYASSYVPYHIMRVLNVDARRRWSTRCPSFADIAQATAALELGPYVGYQVMRGLMPLAFCVHPLLYMAAVPSLGCCCRHCPGYRDSWNPEDAKSTGQALPLNATAAPKPSEPQSRELSQ

Target ORF information:

RefSeq Version	NM_002566.4
Organism	Homo sapiens(human)
Definition	Homo sapiens purinergic receptor P2Y11 (P2RY11), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002566.4

ORF Insert Sequence:

ATGGCAGCCA ACGTCTCGGG TGCCAAGTCC TGCCCTGCCA ACTTCTTGGC AGCTGCCGAC 
GACAAACTCA GTGGGTTCCA GGGGGACTTC CTGTGGCCCA TACTGGTGGT TGAGTTCCTG 
GTGGCCGTGG CCAGCAATGG CCTGGCCCTG TACCGCTTCA GCATCCGGAA GCAGCGCCCA 
TGGCACCCCG CCGTGGTCTT CTCTGTCCAG CTGGCAGTCA GCGACCTGCT CTGCGCCCTG 
ACGCTGCCCC CGCTGGCCGC CTACCTCTAT CCCCCCAAGC ACTGGCGCTA TGGGGAGGCC 
GCGTGCCGCC TGGAGCGCTT CCTCTTCACC TGCAACCTGC TGGGCAGCGT CATCTTCATC 
ACCTGCATCA GCCTCAACCG CTACCTGGGC ATCGTGCACC CCTTCTTCGC CCGAAGCCAC 
CTGCGACCCA AGCACGCCTG GGCCGTGAGC GCTGCCGGCT GGGTCCTGGC CGCCCTGCTG 
GCCATGCCCA CACTCAGCTT CTCCCACCTG AAGAGGCCGC AGCAGGGGGC GGGCAACTGC 
AGCGTGGCCA GGCCCGAGGC CTGCATCAAG TGTCTGGGGA CAGCAGACCA CGGGCTGGCG 
GCCTACAGAG CGTATAGCCT GGTGCTGGCG GGGTTGGGCT GCGGCCTGCC GCTGCTGCTC 
ACGCTGGCAG CCTACGGCGC CCTCGGGCGG GCCGTGCTAC GCAGCCCAGG CATGACTGTG 
GCCGAGAAGC TGCGTGTGGC AGCGTTGGTG GCCAGTGGTG TGGCCCTCTA CGCCAGCTCC 
TATGTGCCCT ACCACATCAT GCGGGTGCTC AACGTGGATG CTCGGCGGCG CTGGAGCACC 
CGCTGCCCGA GCTTTGCAGA CATAGCCCAG GCCACAGCAG CCCTGGAGCT GGGGCCCTAC 
GTGGGCTACC AGGTGATGCG GGGCCTCATG CCCCTGGCCT TCTGTGTCCA CCCTCTACTC 
TACATGGCCG CAGTGCCCAG CCTGGGCTGC TGCTGCCGAC ACTGCCCCGG CTACAGGGAC 
AGCTGGAACC CAGAGGACGC CAAGAGCACT GGCCAAGCCC TGCCCCTCAA TGCCACAGCC 
GCCCCTAAAC CGTCAGAGCC CCAGTCCCGT GAGCTGAGCC AATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

P2RY11 ( NM_002566.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_002557.2 Homo sapiens purinergic receptor P2Y11 (P2RY11), mRNA.

Price & Availability↑

CloneID	OHu03088
Clone ID Related Accession (Same CDS sequence)	NM_002566.4 , NM_002566.5
Accession Version	NM_002566.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1125bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-29
Organism	Homo sapiens(human)
Product	P2Y purinoceptor 11
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC073827.1 and BC009877.2. This sequence is a reference standard in the RefSeqGene project. On Nov 22, 2018 this sequence version replaced NM_002566.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: DB009481.1, BC073827.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000321826.5/ ENSP00000323872.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCAGCCA ACGTCTCGGG TGCCAAGTCC TGCCCTGCCA ACTTCTTGGC AGCTGCCGAC 
GACAAACTCA GTGGGTTCCA GGGGGACTTC CTGTGGCCCA TACTGGTGGT TGAGTTCCTG 
GTGGCCGTGG CCAGCAATGG CCTGGCCCTG TACCGCTTCA GCATCCGGAA GCAGCGCCCA 
TGGCACCCCG CCGTGGTCTT CTCTGTCCAG CTGGCAGTCA GCGACCTGCT CTGCGCCCTG 
ACGCTGCCCC CGCTGGCCGC CTACCTCTAT CCCCCCAAGC ACTGGCGCTA TGGGGAGGCC 
GCGTGCCGCC TGGAGCGCTT CCTCTTCACC TGCAACCTGC TGGGCAGCGT CATCTTCATC 
ACCTGCATCA GCCTCAACCG CTACCTGGGC ATCGTGCACC CCTTCTTCGC CCGAAGCCAC 
CTGCGACCCA AGCACGCCTG GGCCGTGAGC GCTGCCGGCT GGGTCCTGGC CGCCCTGCTG 
GCCATGCCCA CACTCAGCTT CTCCCACCTG AAGAGGCCGC AGCAGGGGGC GGGCAACTGC 
AGCGTGGCCA GGCCCGAGGC CTGCATCAAG TGTCTGGGGA CAGCAGACCA CGGGCTGGCG 
GCCTACAGAG CGTATAGCCT GGTGCTGGCG GGGTTGGGCT GCGGCCTGCC GCTGCTGCTC 
ACGCTGGCAG CCTACGGCGC CCTCGGGCGG GCCGTGCTAC GCAGCCCAGG CATGACTGTG 
GCCGAGAAGC TGCGTGTGGC AGCGTTGGTG GCCAGTGGTG TGGCCCTCTA CGCCAGCTCC 
TATGTGCCCT ACCACATCAT GCGGGTGCTC AACGTGGATG CTCGGCGGCG CTGGAGCACC 
CGCTGCCCGA GCTTTGCAGA CATAGCCCAG GCCACAGCAG CCCTGGAGCT GGGGCCCTAC 
GTGGGCTACC AGGTGATGCG GGGCCTCATG CCCCTGGCCT TCTGTGTCCA CCCTCTACTC 
TACATGGCCG CAGTGCCCAG CCTGGGCTGC TGCTGCCGAC ACTGCCCCGG CTACAGGGAC 
AGCTGGAACC CAGAGGACGC CAAGAGCACT GGCCAAGCCC TGCCCCTCAA TGCCACAGCC 
GCCCCTAAAC CGTCAGAGCC CCAGTCCCGT GAGCTGAGCC AATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002557.2
CDS	30..1154
Translation	MAANVSGAKSCPANFLAAADDKLSGFQGDFLWPILVVEFLVAVASNGLALYRFSIRKQRPWHPAVVFSVQLAVSDLLCALTLPPLAAYLYPPKHWRYGEAACRLERFLFTCNLLGSVIFITCISLNRYLGIVHPFFARSHLRPKHAWAVSAAGWVLAALLAMPTLSFSHLKRPQQGAGNCSVARPEACIKCLGTADHGLAAYRAYSLVLAGLGCGLPLLLTLAAYGALGRAVLRSPGMTVAEKLRVAALVASGVALYASSYVPYHIMRVLNVDARRRWSTRCPSFADIAQATAALELGPYVGYQVMRGLMPLAFCVHPLLYMAAVPSLGCCCRHCPGYRDSWNPEDAKSTGQALPLNATAAPKPSEPQSRELSQ

Target ORF information:

RefSeq Version	NM_002566.5
Organism	Homo sapiens(human)
Definition	Homo sapiens purinergic receptor P2Y11 (P2RY11), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002566.5

ORF Insert Sequence:

ATGGCAGCCA ACGTCTCGGG TGCCAAGTCC TGCCCTGCCA ACTTCTTGGC AGCTGCCGAC 
GACAAACTCA GTGGGTTCCA GGGGGACTTC CTGTGGCCCA TACTGGTGGT TGAGTTCCTG 
GTGGCCGTGG CCAGCAATGG CCTGGCCCTG TACCGCTTCA GCATCCGGAA GCAGCGCCCA 
TGGCACCCCG CCGTGGTCTT CTCTGTCCAG CTGGCAGTCA GCGACCTGCT CTGCGCCCTG 
ACGCTGCCCC CGCTGGCCGC CTACCTCTAT CCCCCCAAGC ACTGGCGCTA TGGGGAGGCC 
GCGTGCCGCC TGGAGCGCTT CCTCTTCACC TGCAACCTGC TGGGCAGCGT CATCTTCATC 
ACCTGCATCA GCCTCAACCG CTACCTGGGC ATCGTGCACC CCTTCTTCGC CCGAAGCCAC 
CTGCGACCCA AGCACGCCTG GGCCGTGAGC GCTGCCGGCT GGGTCCTGGC CGCCCTGCTG 
GCCATGCCCA CACTCAGCTT CTCCCACCTG AAGAGGCCGC AGCAGGGGGC GGGCAACTGC 
AGCGTGGCCA GGCCCGAGGC CTGCATCAAG TGTCTGGGGA CAGCAGACCA CGGGCTGGCG 
GCCTACAGAG CGTATAGCCT GGTGCTGGCG GGGTTGGGCT GCGGCCTGCC GCTGCTGCTC 
ACGCTGGCAG CCTACGGCGC CCTCGGGCGG GCCGTGCTAC GCAGCCCAGG CATGACTGTG 
GCCGAGAAGC TGCGTGTGGC AGCGTTGGTG GCCAGTGGTG TGGCCCTCTA CGCCAGCTCC 
TATGTGCCCT ACCACATCAT GCGGGTGCTC AACGTGGATG CTCGGCGGCG CTGGAGCACC 
CGCTGCCCGA GCTTTGCAGA CATAGCCCAG GCCACAGCAG CCCTGGAGCT GGGGCCCTAC 
GTGGGCTACC AGGTGATGCG GGGCCTCATG CCCCTGGCCT TCTGTGTCCA CCCTCTACTC 
TACATGGCCG CAGTGCCCAG CCTGGGCTGC TGCTGCCGAC ACTGCCCCGG CTACAGGGAC 
AGCTGGAACC CAGAGGACGC CAAGAGCACT GGCCAAGCCC TGCCCCTCAA TGCCACAGCC 
GCCCCTAAAC CGTCAGAGCC CCAGTCCCGT GAGCTGAGCC AATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Carcinoma-specific expression of P2Y11 receptor and its contribution in ATP-induced purinergic signalling and cell migration in human hepatocellular carcinoma cells.
Oncotarget8(23)37278-37290(2017 Jun)
Khalid M,Brisson L,Tariq M,Hao Y,Guibon R,Fromont G,Mortadza SAS,Mousawi F,Manzoor S,Roger S,Jiang LH

Rare missense mutations in P2RY11 in narcolepsy with cataplexy.
Brain : a journal of neurology140(6)1657-1668(2017 Jun)
Degn M,Dauvilliers Y,Dreisig K,Lopez R,Pfister C,Pradervand S,Rahbek Kornum B,Tafti M

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P2RY11 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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