P2RY1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	P2RY1
Entrez Gene ID	5028
Full Name	purinergic receptor P2Y1
Synonyms	P2Y1,SARCC
General protein information	Preferred Names purinergic receptor P2Y1 Names P2Y purinoceptor 1 ATP receptor P2 purinoceptor subtype Y1 platelet ADP receptor purinergic receptor P2Y, G-protein coupled, 1 suppressing androgen receptor in renal cell carcinoma
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 3 Map Location: 3q25.2
Summary	The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor functions as a receptor for extracellular ATP and ADP. In platelets binding to ADP leads to mobilization of intracellular calcium ions via activation of phospholipase C, a change in platelet shape, and probably to platelet aggregation. [provided by RefSeq, Jul 2008].
Disorder MIM:	601167

mRNA and Protein(s)

mRNA	Protein	Name
NM_002563.5	NP_002554.1	P2Y purinoceptor 1
NM_002563.3	NP_002554.1	P2Y purinoceptor 1
NM_002563.4	NP_002554.1	P2Y purinoceptor 1

Pathways from BioSystems

Homologies

Homo sapiens (human)	P2RY1	NP_002554.1
Mus musculus (house mouse)	P2ry1	NP_001268945.1
Gallus gallus (chicken)	P2RY1	NP_990664.1
Danio rerio (zebrafish)	LOC100003922	XP_001343355.1
Rattus norvegicus (Norway rat)	P2ry1	NP_036932.1
Canis lupus familiaris (dog)	P2RY1	NP_001180602.1
Pan troglodytes (chimpanzee)	P2RY1	XP_526353.1
	P2RY1	XP_001106445.1
Xenopus tropicalis (tropical clawed frog)	p2ry1	NP_001096222.1
Bos taurus (cattle)	P2RY1	NP_776835.1

Gene Ontology
Bibliography

Related articles in PubMed

Population-Specific Associations of Deleterious Rare Variants in Coding Region of P2RY1-P2RY12 Purinergic Receptor Genes in Large-Vessel Ischemic Stroke Patients.
Janicki PK, Eyileten C, Ruiz-Velasco V, Sedeek KA, Pordzik J, Czlonkowska A, Kurkowska-Jastrzebska I, Sugino S, Imamura-Kawasawa Y, Mirowska-Guzel D, Postula M
International journal of molecular sciences18(12)(2017 Dec)

Platelet receptor Gene (P2Y12, P2Y1) and platelet glycoprotein Gene (GPIIIa) polymorphisms are associated with antiplatelet drug responsiveness and clinical outcomes after acute minor ischemic stroke.
Yi X, Zhou Q, Wang C, Lin J, Liu P, Fu C
European journal of clinical pharmacology73(4)437-443(2017 Apr)

Tubby family proteins are adapters for ciliary trafficking of integral membrane proteins.
Badgandi HB, Hwang SH, Shimada IS, Loriot E, Mukhopadhyay S
The Journal of cell biology216(3)743-760(2017 Mar)

PI3K? Plays a Key Role in Apolipoprotein A-I-Induced Endothelial Cell Proliferation Through Activation of the Ecto-F1-ATPase/P2Y1 Receptors.
Castaing-Berthou A, Malet N, Radojkovic C, Cabou C, Gayral S, Martinez LO, Laffargue M
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology42(2)579-593(2017)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

aim of this study was to evaluate the effects of platelet receptor gene (P2Y12, P2Y1) and glycoprotein gene (GPIIIa) polymorphisms, as well as their interactions, on antiplatelet drug responsiveness and clinical outcomes in patients with acute MIS
Title: Platelet receptor Gene (P2Y12, P2Y1) and platelet glycoprotein Gene (GPIIIa) polymorphisms are associated with antiplatelet drug responsiveness and clinical outcomes after acute minor ischemic stroke.

these data highlight a key role of the P2Y1/PI3Kbeta axis in endothelial cell proliferation downstream of ecto-F1-ATPase activation by apoA-I. Pharmacological targeting of this pathway could represent a promising approach to enhance vascular endothelial protection.
Title: PI3K? Plays a Key Role in Apolipoprotein A-I-Induced Endothelial Cell Proliferation Through Activation of the Ecto-F1-ATPase/P2Y1 Receptors.

Early neurological deterioration (END) occurred significantly more frequently in patients with aspirin resistance (AR) or high-risk interactive genotypes. Moreover, AR and high-risk interactive genotypes were independently associated with END.
Title: Interaction among COX-2, P2Y1 and GPIIIa gene variants is associated with aspirin resistance and early neurological deterioration in Chinese stroke patients.

ALIX regulates P2Y1 degradation.
Title: ALIX Regulates the Ubiquitin-Independent Lysosomal Sorting of the P2Y1 Purinergic Receptor via a YPX3L Motif.

High extracellular NaCl induces priming of the NLRP3 inflammasome in RPE cells, in part via P2Y1 receptor signaling
Title: P2Y1 Receptor Signaling Contributes to High Salt-Induced Priming of the NLRP3 Inflammasome in Retinal Pigment Epithelial Cells.

The following P2RY1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the P2RY1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu21857	NM_002563.5 Latest version!	Homo sapiens purinergic receptor P2Y1 (P2RY1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
View Old Accession Versions >>
OHu21857	NM_002563.3	Homo sapiens purinergic receptor P2Y, G-protein coupled, 1 (P2RY1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
OHu21857	NM_002563.4	Homo sapiens purinergic receptor P2Y1 (P2RY1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

P2RY1 ( NM_002563.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_002554.1 Homo sapiens purinergic receptor P2Y1 (P2RY1), mRNA.

Price & Availability↑

CloneID	OHu21857
Clone ID Related Accession (Same CDS sequence)	NM_002563.5 , NM_002563.3 , NM_002563.4
Accession Version	NM_002563.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1122bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Homo sapiens(human)
Product	P2Y purinoceptor 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA453416.1, DA396016.1, U42030.1, AC013251.19 and AK026659.1. This sequence is a reference standard in the RefSeqGene project. On Nov 23, 2018 this sequence version replaced NM_002563.4. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: SRR1803615.19852.1, SRR1660805.223567.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000305097.6/ ENSP00000304767.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGACCGAGG TGCTGTGGCC GGCTGTCCCC AACGGGACGG ACGCTGCCTT CCTGGCCGGT 
CCGGGTTCGT CCTGGGGGAA CAGCACGGTC GCCTCCACTG CCGCCGTCTC CTCGTCGTTC 
AAATGCGCCT TGACCAAGAC GGGCTTCCAG TTTTACTACC TGCCGGCTGT CTACATCTTG 
GTATTCATCA TCGGCTTCCT GGGCAACAGC GTGGCCATCT GGATGTTCGT CTTCCACATG 
AAGCCCTGGA GCGGCATCTC CGTGTACATG TTCAATTTGG CTCTGGCCGA CTTCTTGTAC 
GTGCTGACTC TGCCAGCCCT GATCTTCTAC TACTTCAATA AAACAGACTG GATCTTCGGG 
GATGCCATGT GTAAACTGCA GAGGTTCATC TTTCATGTGA ACCTCTATGG CAGCATCTTG 
TTTCTGACAT GCATCAGTGC CCACCGGTAC AGCGGTGTGG TGTACCCCCT CAAGTCCCTG 
GGCCGGCTCA AAAAGAAGAA TGCGATCTGT ATCAGCGTGC TGGTGTGGCT CATTGTGGTG 
GTGGCGATCT CCCCCATCCT CTTCTACTCA GGTACCGGGG TCCGCAAAAA CAAAACCATC 
ACCTGTTACG ACACCACCTC AGACGAGTAC CTGCGAAGTT ATTTCATCTA CAGCATGTGC 
ACGACCGTGG CCATGTTCTG TGTCCCCTTG GTGCTGATTC TGGGCTGTTA CGGATTAATT 
GTGAGAGCTT TGATTTACAA AGATCTGGAC AACTCTCCTC TGAGGAGAAA ATCGATTTAC 
CTGGTAATCA TTGTACTGAC TGTTTTTGCT GTGTCTTACA TCCCTTTCCA TGTGATGAAA 
ACGATGAACT TGAGGGCCCG GCTTGATTTT CAGACCCCAG CAATGTGTGC TTTCAATGAC 
AGGGTTTATG CCACGTATCA GGTGACAAGA GGTCTAGCAA GTCTCAACAG TTGTGTGGAC 
CCCATTCTCT ATTTCTTGGC GGGAGATACT TTCAGAAGGA GACTCTCCCG AGCCACAAGG 
AAAGCTTCTA GAAGAAGTGA GGCAAATTTG CAATCCAAGA GTGAAGACAT GACCCTCAAT 
ATTTTACCTG AGTTCAAGCA GAATGGAGAT ACAAGCCTGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002554.1
CDS	653..1774
Translation	MTEVLWPAVPNGTDAAFLAGPGSSWGNSTVASTAAVSSSFKCALTKTGFQFYYLPAVYILVFIIGFLGNSVAIWMFVFHMKPWSGISVYMFNLALADFLYVLTLPALIFYYFNKTDWIFGDAMCKLQRFIFHVNLYGSILFLTCISAHRYSGVVYPLKSLGRLKKKNAICISVLVWLIVVVAISPILFYSGTGVRKNKTITCYDTTSDEYLRSYFIYSMCTTVAMFCVPLVLILGCYGLIVRALIYKDLDNSPLRRKSIYLVIIVLTVFAVSYIPFHVMKTMNLRARLDFQTPAMCAFNDRVYATYQVTRGLASLNSCVDPILYFLAGDTFRRRLSRATRKASRRSEANLQSKSEDMTLNILPEFKQNGDTSL

Target ORF information:

RefSeq Version	NM_002563.5
Organism	Homo sapiens(human)
Definition	Homo sapiens purinergic receptor P2Y1 (P2RY1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002563.5

ORF Insert Sequence:

ATGACCGAGG TGCTGTGGCC GGCTGTCCCC AACGGGACGG ACGCTGCCTT CCTGGCCGGT 
CCGGGTTCGT CCTGGGGGAA CAGCACGGTC GCCTCCACTG CCGCCGTCTC CTCGTCGTTC 
AAATGCGCCT TGACCAAGAC GGGCTTCCAG TTTTACTACC TGCCGGCTGT CTACATCTTG 
GTATTCATCA TCGGCTTCCT GGGCAACAGC GTGGCCATCT GGATGTTCGT CTTCCACATG 
AAGCCCTGGA GCGGCATCTC CGTGTACATG TTCAATTTGG CTCTGGCCGA CTTCTTGTAC 
GTGCTGACTC TGCCAGCCCT GATCTTCTAC TACTTCAATA AAACAGACTG GATCTTCGGG 
GATGCCATGT GTAAACTGCA GAGGTTCATC TTTCATGTGA ACCTCTATGG CAGCATCTTG 
TTTCTGACAT GCATCAGTGC CCACCGGTAC AGCGGTGTGG TGTACCCCCT CAAGTCCCTG 
GGCCGGCTCA AAAAGAAGAA TGCGATCTGT ATCAGCGTGC TGGTGTGGCT CATTGTGGTG 
GTGGCGATCT CCCCCATCCT CTTCTACTCA GGTACCGGGG TCCGCAAAAA CAAAACCATC 
ACCTGTTACG ACACCACCTC AGACGAGTAC CTGCGAAGTT ATTTCATCTA CAGCATGTGC 
ACGACCGTGG CCATGTTCTG TGTCCCCTTG GTGCTGATTC TGGGCTGTTA CGGATTAATT 
GTGAGAGCTT TGATTTACAA AGATCTGGAC AACTCTCCTC TGAGGAGAAA ATCGATTTAC 
CTGGTAATCA TTGTACTGAC TGTTTTTGCT GTGTCTTACA TCCCTTTCCA TGTGATGAAA 
ACGATGAACT TGAGGGCCCG GCTTGATTTT CAGACCCCAG CAATGTGTGC TTTCAATGAC 
AGGGTTTATG CCACGTATCA GGTGACAAGA GGTCTAGCAA GTCTCAACAG TTGTGTGGAC 
CCCATTCTCT ATTTCTTGGC GGGAGATACT TTCAGAAGGA GACTCTCCCG AGCCACAAGG 
AAAGCTTCTA GAAGAAGTGA GGCAAATTTG CAATCCAAGA GTGAAGACAT GACCCTCAAT 
ATTTTACCTG AGTTCAAGCA GAATGGAGAT ACAAGCCTGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

P2RY1 ( NM_002563.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_002554.1 Homo sapiens purinergic receptor P2Y, G-protein coupled, 1 (P2RY1), mRNA.

Price & Availability↑

CloneID	OHu21857
Clone ID Related Accession (Same CDS sequence)	NM_002563.5 , NM_002563.3 , NM_002563.4
Accession Version	NM_002563.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1122bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2014-05-04
Organism	Homo sapiens(Human)
Product	P2Y purinoceptor 1
Comment

ATGACCGAGG TGCTGTGGCC GGCTGTCCCC AACGGGACGG ACGCTGCCTT CCTGGCCGGT 
CCGGGTTCGT CCTGGGGGAA CAGCACGGTC GCCTCCACTG CCGCCGTCTC CTCGTCGTTC 
AAATGCGCCT TGACCAAGAC GGGCTTCCAG TTTTACTACC TGCCGGCTGT CTACATCTTG 
GTATTCATCA TCGGCTTCCT GGGCAACAGC GTGGCCATCT GGATGTTCGT CTTCCACATG 
AAGCCCTGGA GCGGCATCTC CGTGTACATG TTCAATTTGG CTCTGGCCGA CTTCTTGTAC 
GTGCTGACTC TGCCAGCCCT GATCTTCTAC TACTTCAATA AAACAGACTG GATCTTCGGG 
GATGCCATGT GTAAACTGCA GAGGTTCATC TTTCATGTGA ACCTCTATGG CAGCATCTTG 
TTTCTGACAT GCATCAGTGC CCACCGGTAC AGCGGTGTGG TGTACCCCCT CAAGTCCCTG 
GGCCGGCTCA AAAAGAAGAA TGCGATCTGT ATCAGCGTGC TGGTGTGGCT CATTGTGGTG 
GTGGCGATCT CCCCCATCCT CTTCTACTCA GGTACCGGGG TCCGCAAAAA CAAAACCATC 
ACCTGTTACG ACACCACCTC AGACGAGTAC CTGCGAAGTT ATTTCATCTA CAGCATGTGC 
ACGACCGTGG CCATGTTCTG TGTCCCCTTG GTGCTGATTC TGGGCTGTTA CGGATTAATT 
GTGAGAGCTT TGATTTACAA AGATCTGGAC AACTCTCCTC TGAGGAGAAA ATCGATTTAC 
CTGGTAATCA TTGTACTGAC TGTTTTTGCT GTGTCTTACA TCCCTTTCCA TGTGATGAAA 
ACGATGAACT TGAGGGCCCG GCTTGATTTT CAGACCCCAG CAATGTGTGC TTTCAATGAC 
AGGGTTTATG CCACGTATCA GGTGACAAGA GGTCTAGCAA GTCTCAACAG TTGTGTGGAC 
CCCATTCTCT ATTTCTTGGC GGGAGATACT TTCAGAAGGA GACTCTCCCG AGCCACAAGG 
AAAGCTTCTA GAAGAAGTGA GGCAAATTTG CAATCCAAGA GTGAAGACAT GACCCTCAAT 
ATTTTACCTG AGTTCAAGCA GAATGGAGAT ACAAGCCTGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002554.1
Translation	MTEVLWPAVPNGTDAAFLAGPGSSWGNSTVASTAAVSSSFKCALTKTGFQFYYLPAVYILVFIIGFLGNSVAIWMFVFHMKPWSGISVYMFNLALADFLYVLTLPALIFYYFNKTDWIFGDAMCKLQRFIFHVNLYGSILFLTCISAHRYSGVVYPLKSLGRLKKKNAICISVLVWLIVVVAISPILFYSGTGVRKNKTITCYDTTSDEYLRSYFIYSMCTTVAMFCVPLVLILGCYGLIVRALIYKDLDNSPLRRKSIYLVIIVLTVFAVSYIPFHVMKTMNLRARLDFQTPAMCAFNDRVYATYQVTRGLASLNSCVDPILYFLAGDTFRRRLSRATRKASRRSEANLQSKSEDMTLNILPEFKQNGDTSL

Target ORF information:

RefSeq Version	NM_002563.3
Organism	Homo sapiens(Human)
Definition	Homo sapiens purinergic receptor P2Y, G-protein coupled, 1 (P2RY1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002563.3

ORF Insert Sequence:

ATGACCGAGG TGCTGTGGCC GGCTGTCCCC AACGGGACGG ACGCTGCCTT CCTGGCCGGT 
CCGGGTTCGT CCTGGGGGAA CAGCACGGTC GCCTCCACTG CCGCCGTCTC CTCGTCGTTC 
AAATGCGCCT TGACCAAGAC GGGCTTCCAG TTTTACTACC TGCCGGCTGT CTACATCTTG 
GTATTCATCA TCGGCTTCCT GGGCAACAGC GTGGCCATCT GGATGTTCGT CTTCCACATG 
AAGCCCTGGA GCGGCATCTC CGTGTACATG TTCAATTTGG CTCTGGCCGA CTTCTTGTAC 
GTGCTGACTC TGCCAGCCCT GATCTTCTAC TACTTCAATA AAACAGACTG GATCTTCGGG 
GATGCCATGT GTAAACTGCA GAGGTTCATC TTTCATGTGA ACCTCTATGG CAGCATCTTG 
TTTCTGACAT GCATCAGTGC CCACCGGTAC AGCGGTGTGG TGTACCCCCT CAAGTCCCTG 
GGCCGGCTCA AAAAGAAGAA TGCGATCTGT ATCAGCGTGC TGGTGTGGCT CATTGTGGTG 
GTGGCGATCT CCCCCATCCT CTTCTACTCA GGTACCGGGG TCCGCAAAAA CAAAACCATC 
ACCTGTTACG ACACCACCTC AGACGAGTAC CTGCGAAGTT ATTTCATCTA CAGCATGTGC 
ACGACCGTGG CCATGTTCTG TGTCCCCTTG GTGCTGATTC TGGGCTGTTA CGGATTAATT 
GTGAGAGCTT TGATTTACAA AGATCTGGAC AACTCTCCTC TGAGGAGAAA ATCGATTTAC 
CTGGTAATCA TTGTACTGAC TGTTTTTGCT GTGTCTTACA TCCCTTTCCA TGTGATGAAA 
ACGATGAACT TGAGGGCCCG GCTTGATTTT CAGACCCCAG CAATGTGTGC TTTCAATGAC 
AGGGTTTATG CCACGTATCA GGTGACAAGA GGTCTAGCAA GTCTCAACAG TTGTGTGGAC 
CCCATTCTCT ATTTCTTGGC GGGAGATACT TTCAGAAGGA GACTCTCCCG AGCCACAAGG 
AAAGCTTCTA GAAGAAGTGA GGCAAATTTG CAATCCAAGA GTGAAGACAT GACCCTCAAT 
ATTTTACCTG AGTTCAAGCA GAATGGAGAT ACAAGCCTGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

P2RY1 ( NM_002563.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_002554.1 Homo sapiens purinergic receptor P2Y1 (P2RY1), mRNA.

Price & Availability↑

CloneID	OHu21857
Clone ID Related Accession (Same CDS sequence)	NM_002563.5 , NM_002563.3 , NM_002563.4
Accession Version	NM_002563.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1122bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-10
Organism	Homo sapiens(human)
Product	P2Y purinoceptor 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA453416.1, AC013251.19, DA396016.1, U42030.1 and AK026659.1. This sequence is a reference standard in the RefSeqGene project. On Oct 8, 2015 this sequence version replaced NM_002563.3. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. COMPLETENESS: complete on the 3' end.

ATGACCGAGG TGCTGTGGCC GGCTGTCCCC AACGGGACGG ACGCTGCCTT CCTGGCCGGT 
CCGGGTTCGT CCTGGGGGAA CAGCACGGTC GCCTCCACTG CCGCCGTCTC CTCGTCGTTC 
AAATGCGCCT TGACCAAGAC GGGCTTCCAG TTTTACTACC TGCCGGCTGT CTACATCTTG 
GTATTCATCA TCGGCTTCCT GGGCAACAGC GTGGCCATCT GGATGTTCGT CTTCCACATG 
AAGCCCTGGA GCGGCATCTC CGTGTACATG TTCAATTTGG CTCTGGCCGA CTTCTTGTAC 
GTGCTGACTC TGCCAGCCCT GATCTTCTAC TACTTCAATA AAACAGACTG GATCTTCGGG 
GATGCCATGT GTAAACTGCA GAGGTTCATC TTTCATGTGA ACCTCTATGG CAGCATCTTG 
TTTCTGACAT GCATCAGTGC CCACCGGTAC AGCGGTGTGG TGTACCCCCT CAAGTCCCTG 
GGCCGGCTCA AAAAGAAGAA TGCGATCTGT ATCAGCGTGC TGGTGTGGCT CATTGTGGTG 
GTGGCGATCT CCCCCATCCT CTTCTACTCA GGTACCGGGG TCCGCAAAAA CAAAACCATC 
ACCTGTTACG ACACCACCTC AGACGAGTAC CTGCGAAGTT ATTTCATCTA CAGCATGTGC 
ACGACCGTGG CCATGTTCTG TGTCCCCTTG GTGCTGATTC TGGGCTGTTA CGGATTAATT 
GTGAGAGCTT TGATTTACAA AGATCTGGAC AACTCTCCTC TGAGGAGAAA ATCGATTTAC 
CTGGTAATCA TTGTACTGAC TGTTTTTGCT GTGTCTTACA TCCCTTTCCA TGTGATGAAA 
ACGATGAACT TGAGGGCCCG GCTTGATTTT CAGACCCCAG CAATGTGTGC TTTCAATGAC 
AGGGTTTATG CCACGTATCA GGTGACAAGA GGTCTAGCAA GTCTCAACAG TTGTGTGGAC 
CCCATTCTCT ATTTCTTGGC GGGAGATACT TTCAGAAGGA GACTCTCCCG AGCCACAAGG 
AAAGCTTCTA GAAGAAGTGA GGCAAATTTG CAATCCAAGA GTGAAGACAT GACCCTCAAT 
ATTTTACCTG AGTTCAAGCA GAATGGAGAT ACAAGCCTGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002554.1
CDS	1091..2212
Translation	MTEVLWPAVPNGTDAAFLAGPGSSWGNSTVASTAAVSSSFKCALTKTGFQFYYLPAVYILVFIIGFLGNSVAIWMFVFHMKPWSGISVYMFNLALADFLYVLTLPALIFYYFNKTDWIFGDAMCKLQRFIFHVNLYGSILFLTCISAHRYSGVVYPLKSLGRLKKKNAICISVLVWLIVVVAISPILFYSGTGVRKNKTITCYDTTSDEYLRSYFIYSMCTTVAMFCVPLVLILGCYGLIVRALIYKDLDNSPLRRKSIYLVIIVLTVFAVSYIPFHVMKTMNLRARLDFQTPAMCAFNDRVYATYQVTRGLASLNSCVDPILYFLAGDTFRRRLSRATRKASRRSEANLQSKSEDMTLNILPEFKQNGDTSL

Target ORF information:

RefSeq Version	NM_002563.4
Organism	Homo sapiens(human)
Definition	Homo sapiens purinergic receptor P2Y1 (P2RY1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002563.4

ORF Insert Sequence:

ATGACCGAGG TGCTGTGGCC GGCTGTCCCC AACGGGACGG ACGCTGCCTT CCTGGCCGGT 
CCGGGTTCGT CCTGGGGGAA CAGCACGGTC GCCTCCACTG CCGCCGTCTC CTCGTCGTTC 
AAATGCGCCT TGACCAAGAC GGGCTTCCAG TTTTACTACC TGCCGGCTGT CTACATCTTG 
GTATTCATCA TCGGCTTCCT GGGCAACAGC GTGGCCATCT GGATGTTCGT CTTCCACATG 
AAGCCCTGGA GCGGCATCTC CGTGTACATG TTCAATTTGG CTCTGGCCGA CTTCTTGTAC 
GTGCTGACTC TGCCAGCCCT GATCTTCTAC TACTTCAATA AAACAGACTG GATCTTCGGG 
GATGCCATGT GTAAACTGCA GAGGTTCATC TTTCATGTGA ACCTCTATGG CAGCATCTTG 
TTTCTGACAT GCATCAGTGC CCACCGGTAC AGCGGTGTGG TGTACCCCCT CAAGTCCCTG 
GGCCGGCTCA AAAAGAAGAA TGCGATCTGT ATCAGCGTGC TGGTGTGGCT CATTGTGGTG 
GTGGCGATCT CCCCCATCCT CTTCTACTCA GGTACCGGGG TCCGCAAAAA CAAAACCATC 
ACCTGTTACG ACACCACCTC AGACGAGTAC CTGCGAAGTT ATTTCATCTA CAGCATGTGC 
ACGACCGTGG CCATGTTCTG TGTCCCCTTG GTGCTGATTC TGGGCTGTTA CGGATTAATT 
GTGAGAGCTT TGATTTACAA AGATCTGGAC AACTCTCCTC TGAGGAGAAA ATCGATTTAC 
CTGGTAATCA TTGTACTGAC TGTTTTTGCT GTGTCTTACA TCCCTTTCCA TGTGATGAAA 
ACGATGAACT TGAGGGCCCG GCTTGATTTT CAGACCCCAG CAATGTGTGC TTTCAATGAC 
AGGGTTTATG CCACGTATCA GGTGACAAGA GGTCTAGCAA GTCTCAACAG TTGTGTGGAC 
CCCATTCTCT ATTTCTTGGC GGGAGATACT TTCAGAAGGA GACTCTCCCG AGCCACAAGG 
AAAGCTTCTA GAAGAAGTGA GGCAAATTTG CAATCCAAGA GTGAAGACAT GACCCTCAAT 
ATTTTACCTG AGTTCAAGCA GAATGGAGAT ACAAGCCTGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Population-Specific Associations of Deleterious Rare Variants in Coding Region of P2RY1-P2RY12 Purinergic Receptor Genes in Large-Vessel Ischemic Stroke Patients.
International journal of molecular sciences18(12)(2017 Dec)
Janicki PK,Eyileten C,Ruiz-Velasco V,Sedeek KA,Pordzik J,Czlonkowska A,Kurkowska-Jastrzebska I,Sugino S,Imamura-Kawasawa Y,Mirowska-Guzel D,Postula M

Platelet receptor Gene (P2Y12, P2Y1) and platelet glycoprotein Gene (GPIIIa) polymorphisms are associated with antiplatelet drug responsiveness and clinical outcomes after acute minor ischemic stroke.
European journal of clinical pharmacology73(4)437-443(2017 Apr)
Yi X,Zhou Q,Wang C,Lin J,Liu P,Fu C

Tubby family proteins are adapters for ciliary trafficking of integral membrane proteins.
The Journal of cell biology216(3)743-760(2017 Mar)
Badgandi HB,Hwang SH,Shimada IS,Loriot E,Mukhopadhyay S

PI3K? Plays a Key Role in Apolipoprotein A-I-Induced Endothelial Cell Proliferation Through Activation of the Ecto-F1-ATPase/P2Y1 Receptors.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology42(2)579-593(2017)
Castaing-Berthou A,Malet N,Radojkovic C,Cabou C,Gayral S,Martinez LO,Laffargue M

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P2RY1 cDNA ORF clone, Homo sapiens(human)

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