OTC cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	OTC
Entrez Gene ID	5009
Full Name	ornithine carbamoyltransferase
Synonyms	OCTD
General protein information	Preferred Names ornithine carbamoyltransferase Names ornithine carbamoyltransferase, mitochondrial OTCase ornithine transcarbamylase
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: X Map Location: Xp11.4
Summary	This nuclear gene encodes a mitochondrial matrix enzyme. Missense, nonsense, and frameshift mutations in this enzyme lead to ornithine transcarbamylase deficiency, which causes hyperammonemia. Since the gene for this enzyme maps close to that for Duchenne muscular dystrophy, it may play a role in that disease also. [provided by RefSeq, Jul 2008].
Disorder MIM:	300461
Disorder Html:	Ornithine transcarbamylase deficiency, 311250 (3)

mRNA and Protein(s)

mRNA	Protein	Name
XM_017029556.1	XP_016885045.1	ornithine carbamoyltransferase, mitochondrial isoform X1
NM_000531.6	NP_000522.3	ornithine carbamoyltransferase, mitochondrial precursor
NM_000531.5	NP_000522.3	ornithine carbamoyltransferase, mitochondrial precursor

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	OTC	XP_537995.1
Gallus gallus (chicken)	OTC	NP_990241.1
Schizosaccharomyces pombe (fission yeast)	arg3	NP_593692.1
Neurospora crassa	NCU01667	XP_956873.2
Danio rerio (zebrafish)	otc	XP_001334671.1
Saccharomyces cerevisiae (baker's yeast)	ARG3	NP_012447.1
Xenopus tropicalis (tropical clawed frog)	otc	NP_001005795.1
Homo sapiens (human)	OTC	NP_000522.3
Kluyveromyces lactis	KLLA0F14366g	XP_455725.1
Magnaporthe oryzae (rice blast fungus)	MGG_01102	XP_003717832.1
Rattus norvegicus (Norway rat)	Otc	NP_037210.1
Bos taurus (cattle)	OTC	NP_803453.1
Mus musculus (house mouse)	Otc	NP_032795.1
Eremothecium gossypii	AGOS_AFR098W	NP_985645.1
Arabidopsis thaliana (thale cress)	OTC	NP_177667.1

Gene Ontology
Bibliography

Related articles in PubMed

Disease-causing mutations in the promoter and enhancer of the ornithine transcarbamylase gene.
Jang YJ, LaBella AL, Feeney TP, Braverman N, Tuchman M, Morizono H, Ah Mew N, Caldovic L
Human mutation(2017 Dec)

Involvement of Ornithine Carbamoyltransferase in the Progression of Chronic Hepatitis C and Liver Cirrhosis.
Ohnishi M, Higuchi A, Matsumura H, Arakawa Y, Nakamura H, Nirei K, Yamamoto T, Yamagami H, Ogawa M, Gotoda T, Matsuoka S, Nakajima N, Sugitani M, Moriyama M, Murayama H
International journal of medical sciences14(7)629-638(2017)

A novel mutation in ornithine transcarbamylase gene causing mild intermittent hyperammonemia.
Mohamed S, Hamad MH, Kondkar AA, Abu-Amero KK
Saudi medical journal36(10)1229-32(2015 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Sanger sequencing of the ornithine transcarbamylase (OTC) gene revealed a novel hemizygous deletion at the fourth nucleotide of intron 4 (c.386+4delT) in a child with hyperammonemia and his asymptomatic mother.
Title: A novel mutation in ornithine transcarbamylase gene causing mild intermittent hyperammonemia.

In Korean patients with OTC deficiency, mutations in OTC are genetically heterogeneous.
Title: Clinical outcomes and the mutation spectrum of the OTC gene in patients with ornithine transcarbamylase deficiency.

OTC mutation and phenotype in ornithine transcarbamylase deficiency
Title: Genotype-Phenotype Correlations in Ornithine Transcarbamylase Deficiency: A Mutation Update.

The corresponding OTC tissue enzyme activities were between 3-6% of normal control in mouse and human liver. The use of the cryptic splice sites was reproduced in minigenes carrying murine or human mutant sequences
Title: Functional characterization of the spf/ash splicing variation in OTC deficiency of mice and man.

Data indicate that all of the three patients have carried ornithine transcarbamylase gene mutations, patients 1 and 2 were both hemizygous for mutation c.586G> A(p.D196N).
Title: [Analysis of ornithine transcarbamylase gene mutations in three boys affected with late-onset ornithine transcarbamylase deficiency].

The following OTC gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the OTC cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu24757	NM_000531.6 Latest version!	Homo sapiens ornithine carbamoyltransferase (OTC), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
OHu99325	XM_017029556.1 Latest version!	Homo sapiens ornithine carbamoyltransferase (OTC), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
View Old Accession Versions >>
OHu24757	NM_000531.5	Homo sapiens ornithine carbamoyltransferase (OTC), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

OTC ( NM_000531.6 ) cDNA ORF clone, Homo sapiens(human) -> NP_000522.3 Homo sapiens ornithine carbamoyltransferase (OTC), mRNA.

Price & Availability↑

CloneID	OHu24757
Clone ID Related Accession (Same CDS sequence)	NM_000531.6 , NM_000531.5
Accession Version	NM_000531.6 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1065bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-01
Organism	Homo sapiens(human)
Product	ornithine carbamoyltransferase, mitochondrial precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK292757.1 and AI247721.1. This sequence is a reference standard in the RefSeqGene project. On Nov 23, 2018 this sequence version replaced NM_000531.5. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR5189664.144333.1, SRR5189664.63751.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2142348 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta MANE Ensembl match :: ENST00000039007.5/ ENSP00000039007.4 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGCTGTTTA ATCTGAGGAT CCTGTTAAAC AATGCAGCTT TTAGAAATGG TCACAACTTC 
ATGGTTCGAA ATTTTCGGTG TGGACAACCA CTACAAAATA AAGTGCAGCT GAAGGGCCGT 
GACCTTCTCA CTCTAAAAAA CTTTACCGGA GAAGAAATTA AATATATGCT ATGGCTATCA 
GCAGATCTGA AATTTAGGAT AAAACAGAAA GGAGAGTATT TGCCTTTATT GCAAGGGAAG 
TCCTTAGGCA TGATTTTTGA GAAAAGAAGT ACTCGAACAA GATTGTCTAC AGAAACAGGC 
TTTGCACTTC TGGGAGGACA TCCTTGTTTT CTTACCACAC AAGATATTCA TTTGGGTGTG 
AATGAAAGTC TCACGGACAC GGCCCGTGTA TTGTCTAGCA TGGCAGATGC AGTATTGGCT 
CGAGTGTATA AACAATCAGA TTTGGACACC CTGGCTAAAG AAGCATCCAT CCCAATTATC 
AATGGGCTGT CAGATTTGTA CCATCCTATC CAGATCCTGG CTGATTACCT CACGCTCCAG 
GAACACTATA GCTCTCTGAA AGGTCTTACC CTCAGCTGGA TCGGGGATGG GAACAATATC 
CTGCACTCCA TCATGATGAG CGCAGCGAAA TTCGGAATGC ACCTTCAGGC AGCTACTCCA 
AAGGGTTATG AGCCGGATGC TAGTGTAACC AAGTTGGCAG AGCAGTATGC CAAAGAGAAT 
GGTACCAAGC TGTTGCTGAC AAATGATCCA TTGGAAGCAG CGCATGGAGG CAATGTATTA 
ATTACAGACA CTTGGATAAG CATGGGACAA GAAGAGGAGA AGAAAAAGCG GCTCCAGGCT 
TTCCAAGGTT ACCAGGTTAC AATGAAGACT GCTAAAGTTG CTGCCTCTGA CTGGACATTT 
TTACACTGCT TGCCCAGAAA GCCAGAAGAA GTGGATGATG AAGTCTTTTA TTCTCCTCGA 
TCACTAGTGT TCCCAGAGGC AGAAAACAGA AAGTGGACAA TCATGGCTGT CATGGTGTCC 
CTGCTGACAG ATTACTCACC TCAGCTCCAG AAGCCTAAAT TTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000522.3
CDS	94..1158
Translation	MLFNLRILLNNAAFRNGHNFMVRNFRCGQPLQNKVQLKGRDLLTLKNFTGEEIKYMLWLSADLKFRIKQKGEYLPLLQGKSLGMIFEKRSTRTRLSTETGFALLGGHPCFLTTQDIHLGVNESLTDTARVLSSMADAVLARVYKQSDLDTLAKEASIPIINGLSDLYHPIQILADYLTLQEHYSSLKGLTLSWIGDGNNILHSIMMSAAKFGMHLQAATPKGYEPDASVTKLAEQYAKENGTKLLLTNDPLEAAHGGNVLITDTWISMGQEEEKKKRLQAFQGYQVTMKTAKVAASDWTFLHCLPRKPEEVDDEVFYSPRSLVFPEAENRKWTIMAVMVSLLTDYSPQLQKPKF

Target ORF information:

RefSeq Version	NM_000531.6
Organism	Homo sapiens(human)
Definition	Homo sapiens ornithine carbamoyltransferase (OTC), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000531.6

ORF Insert Sequence:

ATGCTGTTTA ATCTGAGGAT CCTGTTAAAC AATGCAGCTT TTAGAAATGG TCACAACTTC 
ATGGTTCGAA ATTTTCGGTG TGGACAACCA CTACAAAATA AAGTGCAGCT GAAGGGCCGT 
GACCTTCTCA CTCTAAAAAA CTTTACCGGA GAAGAAATTA AATATATGCT ATGGCTATCA 
GCAGATCTGA AATTTAGGAT AAAACAGAAA GGAGAGTATT TGCCTTTATT GCAAGGGAAG 
TCCTTAGGCA TGATTTTTGA GAAAAGAAGT ACTCGAACAA GATTGTCTAC AGAAACAGGC 
TTTGCACTTC TGGGAGGACA TCCTTGTTTT CTTACCACAC AAGATATTCA TTTGGGTGTG 
AATGAAAGTC TCACGGACAC GGCCCGTGTA TTGTCTAGCA TGGCAGATGC AGTATTGGCT 
CGAGTGTATA AACAATCAGA TTTGGACACC CTGGCTAAAG AAGCATCCAT CCCAATTATC 
AATGGGCTGT CAGATTTGTA CCATCCTATC CAGATCCTGG CTGATTACCT CACGCTCCAG 
GAACACTATA GCTCTCTGAA AGGTCTTACC CTCAGCTGGA TCGGGGATGG GAACAATATC 
CTGCACTCCA TCATGATGAG CGCAGCGAAA TTCGGAATGC ACCTTCAGGC AGCTACTCCA 
AAGGGTTATG AGCCGGATGC TAGTGTAACC AAGTTGGCAG AGCAGTATGC CAAAGAGAAT 
GGTACCAAGC TGTTGCTGAC AAATGATCCA TTGGAAGCAG CGCATGGAGG CAATGTATTA 
ATTACAGACA CTTGGATAAG CATGGGACAA GAAGAGGAGA AGAAAAAGCG GCTCCAGGCT 
TTCCAAGGTT ACCAGGTTAC AATGAAGACT GCTAAAGTTG CTGCCTCTGA CTGGACATTT 
TTACACTGCT TGCCCAGAAA GCCAGAAGAA GTGGATGATG AAGTCTTTTA TTCTCCTCGA 
TCACTAGTGT TCCCAGAGGC AGAAAACAGA AAGTGGACAA TCATGGCTGT CATGGTGTCC 
CTGCTGACAG ATTACTCACC TCAGCTCCAG AAGCCTAAAT TTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

OTC ( NM_000531.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_000522.3 Homo sapiens ornithine carbamoyltransferase (OTC), mRNA.

Price & Availability↑

CloneID	OHu24757
Clone ID Related Accession (Same CDS sequence)	NM_000531.6 , NM_000531.5
Accession Version	NM_000531.5	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1065bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	ornithine carbamoyltransferase, mitochondrial precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC107153.1, AK292757.1 and AI247721.1. This sequence is a reference standard in the RefSeqGene project. On Aug 21, 2008 this sequence version replaced NM_000531.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC107153.1, SRR1660803.257899.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2142348 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGCTGTTTA ATCTGAGGAT CCTGTTAAAC AATGCAGCTT TTAGAAATGG TCACAACTTC 
ATGGTTCGAA ATTTTCGGTG TGGACAACCA CTACAAAATA AAGTGCAGCT GAAGGGCCGT 
GACCTTCTCA CTCTAAAAAA CTTTACCGGA GAAGAAATTA AATATATGCT ATGGCTATCA 
GCAGATCTGA AATTTAGGAT AAAACAGAAA GGAGAGTATT TGCCTTTATT GCAAGGGAAG 
TCCTTAGGCA TGATTTTTGA GAAAAGAAGT ACTCGAACAA GATTGTCTAC AGAAACAGGC 
TTTGCACTTC TGGGAGGACA TCCTTGTTTT CTTACCACAC AAGATATTCA TTTGGGTGTG 
AATGAAAGTC TCACGGACAC GGCCCGTGTA TTGTCTAGCA TGGCAGATGC AGTATTGGCT 
CGAGTGTATA AACAATCAGA TTTGGACACC CTGGCTAAAG AAGCATCCAT CCCAATTATC 
AATGGGCTGT CAGATTTGTA CCATCCTATC CAGATCCTGG CTGATTACCT CACGCTCCAG 
GAACACTATA GCTCTCTGAA AGGTCTTACC CTCAGCTGGA TCGGGGATGG GAACAATATC 
CTGCACTCCA TCATGATGAG CGCAGCGAAA TTCGGAATGC ACCTTCAGGC AGCTACTCCA 
AAGGGTTATG AGCCGGATGC TAGTGTAACC AAGTTGGCAG AGCAGTATGC CAAAGAGAAT 
GGTACCAAGC TGTTGCTGAC AAATGATCCA TTGGAAGCAG CGCATGGAGG CAATGTATTA 
ATTACAGACA CTTGGATAAG CATGGGACAA GAAGAGGAGA AGAAAAAGCG GCTCCAGGCT 
TTCCAAGGTT ACCAGGTTAC AATGAAGACT GCTAAAGTTG CTGCCTCTGA CTGGACATTT 
TTACACTGCT TGCCCAGAAA GCCAGAAGAA GTGGATGATG AAGTCTTTTA TTCTCCTCGA 
TCACTAGTGT TCCCAGAGGC AGAAAACAGA AAGTGGACAA TCATGGCTGT CATGGTGTCC 
CTGCTGACAG ATTACTCACC TCAGCTCCAG AAGCCTAAAT TTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000522.3
CDS	215..1279
Translation	MLFNLRILLNNAAFRNGHNFMVRNFRCGQPLQNKVQLKGRDLLTLKNFTGEEIKYMLWLSADLKFRIKQKGEYLPLLQGKSLGMIFEKRSTRTRLSTETGFALLGGHPCFLTTQDIHLGVNESLTDTARVLSSMADAVLARVYKQSDLDTLAKEASIPIINGLSDLYHPIQILADYLTLQEHYSSLKGLTLSWIGDGNNILHSIMMSAAKFGMHLQAATPKGYEPDASVTKLAEQYAKENGTKLLLTNDPLEAAHGGNVLITDTWISMGQEEEKKKRLQAFQGYQVTMKTAKVAASDWTFLHCLPRKPEEVDDEVFYSPRSLVFPEAENRKWTIMAVMVSLLTDYSPQLQKPKF

Target ORF information:

RefSeq Version	NM_000531.5
Organism	Homo sapiens(human)
Definition	Homo sapiens ornithine carbamoyltransferase (OTC), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000531.5

ORF Insert Sequence:

ATGCTGTTTA ATCTGAGGAT CCTGTTAAAC AATGCAGCTT TTAGAAATGG TCACAACTTC 
ATGGTTCGAA ATTTTCGGTG TGGACAACCA CTACAAAATA AAGTGCAGCT GAAGGGCCGT 
GACCTTCTCA CTCTAAAAAA CTTTACCGGA GAAGAAATTA AATATATGCT ATGGCTATCA 
GCAGATCTGA AATTTAGGAT AAAACAGAAA GGAGAGTATT TGCCTTTATT GCAAGGGAAG 
TCCTTAGGCA TGATTTTTGA GAAAAGAAGT ACTCGAACAA GATTGTCTAC AGAAACAGGC 
TTTGCACTTC TGGGAGGACA TCCTTGTTTT CTTACCACAC AAGATATTCA TTTGGGTGTG 
AATGAAAGTC TCACGGACAC GGCCCGTGTA TTGTCTAGCA TGGCAGATGC AGTATTGGCT 
CGAGTGTATA AACAATCAGA TTTGGACACC CTGGCTAAAG AAGCATCCAT CCCAATTATC 
AATGGGCTGT CAGATTTGTA CCATCCTATC CAGATCCTGG CTGATTACCT CACGCTCCAG 
GAACACTATA GCTCTCTGAA AGGTCTTACC CTCAGCTGGA TCGGGGATGG GAACAATATC 
CTGCACTCCA TCATGATGAG CGCAGCGAAA TTCGGAATGC ACCTTCAGGC AGCTACTCCA 
AAGGGTTATG AGCCGGATGC TAGTGTAACC AAGTTGGCAG AGCAGTATGC CAAAGAGAAT 
GGTACCAAGC TGTTGCTGAC AAATGATCCA TTGGAAGCAG CGCATGGAGG CAATGTATTA 
ATTACAGACA CTTGGATAAG CATGGGACAA GAAGAGGAGA AGAAAAAGCG GCTCCAGGCT 
TTCCAAGGTT ACCAGGTTAC AATGAAGACT GCTAAAGTTG CTGCCTCTGA CTGGACATTT 
TTACACTGCT TGCCCAGAAA GCCAGAAGAA GTGGATGATG AAGTCTTTTA TTCTCCTCGA 
TCACTAGTGT TCCCAGAGGC AGAAAACAGA AAGTGGACAA TCATGGCTGT CATGGTGTCC 
CTGCTGACAG ATTACTCACC TCAGCTCCAG AAGCCTAAAT TTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

OTC ( XM_017029556.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016885045.1 Homo sapiens ornithine carbamoyltransferase (OTC), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu99325
Clone ID Related Accession (Same CDS sequence)	XM_017029556.1
Accession Version	XM_017029556.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 936bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	ornithine carbamoyltransferase, mitochondrial isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000023.11) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCTGTTTA ATCTGAGGAT CCTGTTAAAC AATGCAGCTT TTAGAAATGG TCACAACTTC 
ATGGTTCGAA ATTTTCGGTG TGGACAACCA CTACAAAATA AAGTGCAGCT GAAGGGCCGT 
GACCTTCTCA CTCTAAAAAA CTTTACCGGA GAAGAAATTA AATATATGCT ATGGCTATCA 
GCAGATCTGA AATTTAGGAT AAAACAGAAA GGAGAGTATT TGCCTTTATT GCAAGGGAAG 
TCCTTAGGCA TGATTTTTGA GAAAAGAAGT ACTCGAACAA GATTGTCTAC AGAAACAGGC 
TTTGCACTTC TGGGAGGACA TCCTTGTTTT CTTACCACAC AAGATATTCA TTTGGGTGTG 
AATGAAAGTC TCACGGACAC GGCCCGTGTA TTGTCTAGCA TGGCAGATGC AGTATTGGCT 
CGAGTGTATA AACAATCAGA TTTGGACACC CTGGCTAAAG AAGCATCCAT CCCAATTATC 
AATGGGCTGT CAGATTTGTA CCATCCTATC CAGATCCTGG CTGATTACCT CACGCTCCAG 
GAACACTATA GCTCTCTGAA AGGTCTTACC CTCAGCTGGA TCGGGGATGG GAACAATATC 
CTGCACTCCA TCATGATGAG CGCAGCGAAA TTCGGAATGC ACCTTCAGGC AGCTACTCCA 
AAGGGTTATG AGCCGGATGC TAGTGTAACC AAGTTGGCAG AGCAGTATGC CAAAGAGAAT 
GGTACCAAGC TGTTGCTGAC AAATGATCCA TTGGAAGCAG CGCATGGAGG CAATGTATTA 
ATTACAGACA CTTGGATAAG CATGGGACAA GAAGAGGAGA AGAAAAAGCG GCTCCAGGCT 
TTCCAAGGTT ACCAGGTTAC AATGAAGATA CTGAAGAAAA CAAATATGAC TGCCACATAT 
AATAGTCAAA AAGTGGTCTT ATCCCCATCT CTTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016885045.1
CDS	170..1105
Translation	MLFNLRILLNNAAFRNGHNFMVRNFRCGQPLQNKVQLKGRDLLTLKNFTGEEIKYMLWLSADLKFRIKQKGEYLPLLQGKSLGMIFEKRSTRTRLSTETGFALLGGHPCFLTTQDIHLGVNESLTDTARVLSSMADAVLARVYKQSDLDTLAKEASIPIINGLSDLYHPIQILADYLTLQEHYSSLKGLTLSWIGDGNNILHSIMMSAAKFGMHLQAATPKGYEPDASVTKLAEQYAKENGTKLLLTNDPLEAAHGGNVLITDTWISMGQEEEKKKRLQAFQGYQVTMKILKKTNMTATYNSQKVVLSPSL

Target ORF information:

RefSeq Version	XM_017029556.1
Organism	Homo sapiens(human)
Definition	Homo sapiens ornithine carbamoyltransferase (OTC), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017029556.1

ORF Insert Sequence:

ATGCTGTTTA ATCTGAGGAT CCTGTTAAAC AATGCAGCTT TTAGAAATGG TCACAACTTC 
ATGGTTCGAA ATTTTCGGTG TGGACAACCA CTACAAAATA AAGTGCAGCT GAAGGGCCGT 
GACCTTCTCA CTCTAAAAAA CTTTACCGGA GAAGAAATTA AATATATGCT ATGGCTATCA 
GCAGATCTGA AATTTAGGAT AAAACAGAAA GGAGAGTATT TGCCTTTATT GCAAGGGAAG 
TCCTTAGGCA TGATTTTTGA GAAAAGAAGT ACTCGAACAA GATTGTCTAC AGAAACAGGC 
TTTGCACTTC TGGGAGGACA TCCTTGTTTT CTTACCACAC AAGATATTCA TTTGGGTGTG 
AATGAAAGTC TCACGGACAC GGCCCGTGTA TTGTCTAGCA TGGCAGATGC AGTATTGGCT 
CGAGTGTATA AACAATCAGA TTTGGACACC CTGGCTAAAG AAGCATCCAT CCCAATTATC 
AATGGGCTGT CAGATTTGTA CCATCCTATC CAGATCCTGG CTGATTACCT CACGCTCCAG 
GAACACTATA GCTCTCTGAA AGGTCTTACC CTCAGCTGGA TCGGGGATGG GAACAATATC 
CTGCACTCCA TCATGATGAG CGCAGCGAAA TTCGGAATGC ACCTTCAGGC AGCTACTCCA 
AAGGGTTATG AGCCGGATGC TAGTGTAACC AAGTTGGCAG AGCAGTATGC CAAAGAGAAT 
GGTACCAAGC TGTTGCTGAC AAATGATCCA TTGGAAGCAG CGCATGGAGG CAATGTATTA 
ATTACAGACA CTTGGATAAG CATGGGACAA GAAGAGGAGA AGAAAAAGCG GCTCCAGGCT 
TTCCAAGGTT ACCAGGTTAC AATGAAGATA CTGAAGAAAA CAAATATGAC TGCCACATAT 
AATAGTCAAA AAGTGGTCTT ATCCCCATCT CTTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Disease-causing mutations in the promoter and enhancer of the ornithine transcarbamylase gene.
Human mutation(2017 Dec)
Jang YJ,LaBella AL,Feeney TP,Braverman N,Tuchman M,Morizono H,Ah Mew N,Caldovic L

Involvement of Ornithine Carbamoyltransferase in the Progression of Chronic Hepatitis C and Liver Cirrhosis.
International journal of medical sciences14(7)629-638(2017)
Ohnishi M,Higuchi A,Matsumura H,Arakawa Y,Nakamura H,Nirei K,Yamamoto T,Yamagami H,Ogawa M,Gotoda T,Matsuoka S,Nakajima N,Sugitani M,Moriyama M,Murayama H

A novel mutation in ornithine transcarbamylase gene causing mild intermittent hyperammonemia.
Saudi medical journal36(10)1229-32(2015 Oct)
Mohamed S,Hamad MH,Kondkar AA,Abu-Amero KK

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OTC cDNA ORF clone, Homo sapiens(human)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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