ACO2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	ACO2
Entrez Gene ID	50
Full Name	aconitase 2
Synonyms	ACONM,HEL-S-284,ICRD,OCA8,OPA9
General protein information	Preferred Names aconitase 2 Names aconitate hydratase, mitochondrial aconitase 2, mitochondrial citrate hydro-lyase epididymis secretory sperm binding protein Li 284 mitochondrial aconitase
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 22 Map Location: 22q13.2
Summary	The protein encoded by this gene belongs to the aconitase/IPM isomerase family. It is an enzyme that catalyzes the interconversion of citrate to isocitrate via cis-aconitate in the second step of the TCA cycle. This protein is encoded in the nucleus and functions in the mitochondrion. It was found to be one of the mitochondrial matrix proteins that are preferentially degraded by the serine protease 15(PRSS15), also known as Lon protease, after oxidative modification. [provided by RefSeq, Jul 2008].
Disorder MIM:	100850
Disorder Html:	Infantile cerebellar-retinal degeneration, 614559 (3); ?Optic atrophy 9, 616289 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001098.2	NP_001089.1	aconitate hydratase, mitochondrial precursor
XM_024452250.1	XP_024308018.1	aconitate hydratase, mitochondrial isoform X1
XM_017028812.1	XP_016884301.1	aconitate hydratase, mitochondrial isoform X2
NM_001098.3	NP_001089.1	aconitate hydratase, mitochondrial precursor

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Aco2	NP_542364.1
Caenorhabditis elegans (roundworm)	aco-2	NP_741235.1
Saccharomyces cerevisiae (baker's yeast)	ACO1	NP_013407.1
Canis lupus familiaris (dog)	ACO2	XP_849166.1
Gallus gallus (chicken)	ACO2	NP_989519.1
	ACO2	XP_001105023.1
Drosophila melanogaster (fruit fly)	Acon	NP_001163030.1
Bos taurus (cattle)	ACO2	NP_776402.1
Rattus norvegicus (Norway rat)	Aco2	NP_077374.2
Danio rerio (zebrafish)	aco2	NP_944590.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP007852	XP_317642.4
Eremothecium gossypii	AGOS_ADL032W	NP_984065.1
Schizosaccharomyces pombe (fission yeast)	SPAC24C9.06c	NP_594031.2
Magnaporthe oryzae (rice blast fungus)	MGG_03521	XP_003716398.1
Neurospora crassa	NCU02366	XP_959787.1
Xenopus tropicalis (tropical clawed frog)	aco2	NP_001011445.1
Homo sapiens (human)	ACO2	NP_001089.1
Kluyveromyces lactis	KLLA0C17314g	XP_452974.1

Gene Ontology
Bibliography

Related articles in PubMed

Altered Aconitase 2 Activity in Huntington's Disease Peripheral Blood Cells and Mouse Model Striatum.
Chen CM, Wu YR, Chang KH
International journal of molecular sciences18(11)(2017 Nov)

Mitochondrial aconitase in Neurodegenerative disorders: role of a metabolism-related molecule in neurodegeneration.
Khodagholi F, Shaerzadeh F, Montazeri F
Current drug targets(2017 Aug)

Lymphocytic mitochondrial aconitase activity is reduced in Alzheimer's disease and mild cognitive impairment.
Mangialasche F, Baglioni M, Cecchetti R, Kivipelto M, Ruggiero C, Piobbico D, Kussmaul L, Monastero R, Brancorsini S, Mecocci P
Journal of Alzheimer's disease : JAD44(2)649-60(2015)

Mutations in the tricarboxylic acid cycle enzyme, aconitase 2, cause either isolated or syndromic optic neuropathy with encephalopathy and cerebellar atrophy.
Metodiev MD, Gerber S, Hubert L, Delahodde A, Chretien D, G?rard X, Amati-Bonneau P, Giacomotto MC, Boddaert N, Kaminska A, Desguerre I, Amiel J, Rio M, Kaplan J, Munnich A, R?tig A, Rozet JM, Besmond C
Journal of medical genetics51(12)834-8(2014 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Results suggest that ACO2 activity is reduced in peripheral lymphocytes of subjects with Alzheimer's disease and mild cognitive impairment and correlates with antioxidant protection
Title: Lymphocytic mitochondrial aconitase activity is reduced in Alzheimer's disease and mild cognitive impairment.

Our study shows that autosomal recessive ACO2 mutations can cause either isolated or syndromic optic neuropathy.
Title: Mutations in the tricarboxylic acid cycle enzyme, aconitase 2, cause either isolated or syndromic optic neuropathy with encephalopathy and cerebellar atrophy.

immunofluorescence staining localized ACO2 to the human sperm mid-piece. By immunoblotting, we demonstrated that the level of ACO2 protein in asthenozoospermic samples was significantly decreased compared with that in normal fertile men
Title: The role of mitochondrial aconitate (ACO2) in human sperm motility.

Ogg1 chaperoning of Aco-2 in preventing oxidant-mediated mtDNA damage and apoptosis may afford an innovative target for the molecular events underlying oxidant-induced toxicity.
Title: Mitochondria-targeted Ogg1 and aconitase-2 prevent oxidant-induced mitochondrial DNA damage in alveolar epithelial cells.

Hypoxia upregulates the gene expression of mitochondrial aconitase in prostate carcinoma cells
Title: Hypoxia upregulates the gene expression of mitochondrial aconitase in prostate carcinoma cells.

The following ACO2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ACO2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu18968	NM_001098.3 Latest version!	Homo sapiens aconitase 2 (ACO2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$265.30 $379.00
OHu18968	XM_024452250.1 Latest version!	Homo sapiens aconitase 2 (ACO2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$265.30 $379.00
OHu93505	XM_017028812.1 Latest version!	Homo sapiens aconitase 2 (ACO2), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$391.30 $559.00
View Old Accession Versions >>
OHu18968	NM_001098.2	Homo sapiens aconitase 2 (ACO2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$265.30 $379.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

ACO2 ( NM_001098.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001089.1 Homo sapiens aconitase 2 (ACO2), mRNA.

Price & Availability↑

CloneID	OHu18968
Clone ID Related Accession (Same CDS sequence)	NM_001098.2 , XM_024452250.1 , NM_001098.3
Accession Version	NM_001098.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2343bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-30
Organism	Homo sapiens(human)
Product	aconitate hydratase, mitochondrial precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC026196.2, BC014092.2 and AA724140.1. This sequence is a reference standard in the RefSeqGene project. On Apr 20, 2004 this sequence version replaced NM_001098.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC014092.2, SRR1803611.119949.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCGCCCT ACAGCCTACT GGTGACTCGG CTGCAGAAAG CTCTGGGTGT GCGGCAGTAC 
CATGTGGCCT CAGTCCTGTG CCAACGGGCC AAGGTGGCGA TGAGCCACTT TGAGCCCAAC 
GAGTACATCC ATTATGACCT GCTAGAGAAG AACATTAACA TTGTTCGCAA ACGACTGAAC 
CGGCCGCTGA CACTCTCGGA GAAGATTGTG TATGGACACC TGGATGACCC CGCCAGCCAG 
GAAATTGAGC GAGGCAAGTC GTACCTGCGG CTGCGGCCGG ACCGTGTGGC CATGCAGGAT 
GCGACGGCCC AGATGGCCAT GCTCCAGTTC ATCAGCAGCG GGCTGTCCAA GGTGGCTGTG 
CCATCCACCA TCCACTGTGA CCATCTGATT GAAGCCCAGG TTGGGGGCGA GAAAGACCTG 
CGCCGGGCCA AGGACATCAA CCAGGAAGTT TATAATTTCC TGGCAACTGC AGGTGCCAAA 
TATGGCGTGG GCTTCTGGAA GCCTGGATCT GGAATCATTC ACCAGATTAT TCTGGAAAAC 
TATGCGTACC CTGGTGTTCT TCTGATTGGC ACTGACTCCC ACACCCCCAA TGGTGGCGGC 
CTTGGGGGCA TCTGCATTGG AGTTGGGGGT GCCGATGCTG TGGATGTCAT GGCTGGGATC 
CCCTGGGAGC TGAAGTGCCC CAAGGTGATT GGCGTGAAGC TGACGGGCTC TCTCTCCGGT 
TGGTCCTCAC CCAAAGATGT GATCCTGAAG GTGGCAGGCA TCCTCACGGT GAAAGGTGGC 
ACAGGTGCAA TCGTGGAATA CCACGGGCCT GGTGTAGACT CCATCTCCTG CACTGGCATG 
GCGACAATCT GCAACATGGG TGCAGAAATT GGGGCCACCA CTTCCGTGTT CCCTTACAAC 
CACAGGATGA AGAAGTACCT GAGCAAGACC GGCCGGGAAG ACATTGCCAA TCTAGCTGAT 
GAATTCAAGG ATCACTTGGT GCCTGACCCT GGCTGCCATT ATGACCAACT AATTGAAATT 
AACCTCAGTG AGCTGAAGCC ACACATCAAT GGGCCCTTCA CCCCTGACCT GGCTCACCCT 
GTGGCAGAAG TGGGCAAGGT GGCAGAGAAG GAAGGATGGC CTCTGGACAT CCGAGTGGGT 
CTAATTGGTA GCTGCACCAA TTCAAGCTAT GAAGATATGG GGCGCTCAGC AGCTGTGGCC 
AAGCAGGCAC TGGCCCATGG CCTCAAGTGC AAGTCCCAGT TCACCATCAC TCCAGGTTCC 
GAGCAGATCC GCGCCACCAT TGAGCGGGAC GGCTATGCAC AGATCTTGAG GGATCTGGGT 
GGCATTGTCC TGGCCAATGC TTGTGGCCCC TGCATTGGCC AGTGGGACAG GAAGGACATC 
AAGAAGGGGG AGAAGAACAC AATCGTCACC TCCTACAACA GGAACTTCAC GGGCCGCAAC 
GACGCAAACC CCGAGACCCA TGCCTTTGTC ACGTCCCCAG AGATTGTCAC AGCCCTGGCC 
ATTGCGGGAA CCCTCAAGTT CAACCCAGAG ACCGACTACC TGACGGGCAC GGATGGCAAG 
AAGTTCAGGC TGGAGGCTCC GGATGCAGAT GAGCTTCCCA AAGGGGAGTT TGACCCAGGG 
CAGGACACCT ACCAGCACCC ACCCAAGGAC AGCAGCGGGC AGCATGTGGA CGTGAGCCCC 
ACCAGCCAGC GCCTGCAGCT CCTGGAGCCT TTTGACAAGT GGGATGGCAA GGACCTGGAG 
GACCTGCAGA TCCTCATCAA GGTCAAAGGG AAGTGTACCA CTGACCACAT CTCAGCTGCT 
GGCCCCTGGC TCAAGTTCCG TGGGCACTTG GATAACATCT CCAACAACCT GCTCATTGGT 
GCCATCAACA TTGAAAACGG CAAGGCCAAC TCCGTGCGCA ATGCCGTCAC TCAGGAGTTT 
GGCCCCGTCC CTGACACTGC CCGCTACTAC AAGAAACATG GCATCAGGTG GGTGGTGATC 
GGAGACGAGA ACTACGGCGA GGGCTCGAGC CGGGAGCATG CAGCTCTGGA GCCTCGCCAC 
CTTGGGGGCC GGGCCATCAT CACCAAGAGC TTTGCCAGGA TCCACGAGAC CAACCTGAAG 
AAACAGGGCC TGCTGCCTCT GACCTTCGCT GACCCGGCTG ACTACAACAA GATTCACCCT 
GTGGACAAGC TGACCATTCA GGGCCTGAAG GACTTCACCC CTGGCAAGCC CCTGAAGTGC 
ATCATCAAGC ACCCCAACGG GACCCAGGAG ACCATCCTCC TGAACCACAC CTTCAACGAG 
ACGCAGATTG AGTGGTTCCG CGCTGGCAGT GCCCTCAACA GAATGAAGGA ACTGCAACAG 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001089.1
CDS	23..2365
Translation	MAPYSLLVTRLQKALGVRQYHVASVLCQRAKVAMSHFEPNEYIHYDLLEKNINIVRKRLNRPLTLSEKIVYGHLDDPASQEIERGKSYLRLRPDRVAMQDATAQMAMLQFISSGLSKVAVPSTIHCDHLIEAQVGGEKDLRRAKDINQEVYNFLATAGAKYGVGFWKPGSGIIHQIILENYAYPGVLLIGTDSHTPNGGGLGGICIGVGGADAVDVMAGIPWELKCPKVIGVKLTGSLSGWSSPKDVILKVAGILTVKGGTGAIVEYHGPGVDSISCTGMATICNMGAEIGATTSVFPYNHRMKKYLSKTGREDIANLADEFKDHLVPDPGCHYDQLIEINLSELKPHINGPFTPDLAHPVAEVGKVAEKEGWPLDIRVGLIGSCTNSSYEDMGRSAAVAKQALAHGLKCKSQFTITPGSEQIRATIERDGYAQILRDLGGIVLANACGPCIGQWDRKDIKKGEKNTIVTSYNRNFTGRNDANPETHAFVTSPEIVTALAIAGTLKFNPETDYLTGTDGKKFRLEAPDADELPKGEFDPGQDTYQHPPKDSSGQHVDVSPTSQRLQLLEPFDKWDGKDLEDLQILIKVKGKCTTDHISAAGPWLKFRGHLDNISNNLLIGAINIENGKANSVRNAVTQEFGPVPDTARYYKKHGIRWVVIGDENYGEGSSREHAALEPRHLGGRAIITKSFARIHETNLKKQGLLPLTFADPADYNKIHPVDKLTIQGLKDFTPGKPLKCIIKHPNGTQETILLNHTFNETQIEWFRAGSALNRMKELQQ

Target ORF information:

RefSeq Version	NM_001098.2
Organism	Homo sapiens(human)
Definition	Homo sapiens aconitase 2 (ACO2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001098.2

ORF Insert Sequence:

ATGGCGCCCT ACAGCCTACT GGTGACTCGG CTGCAGAAAG CTCTGGGTGT GCGGCAGTAC 
CATGTGGCCT CAGTCCTGTG CCAACGGGCC AAGGTGGCGA TGAGCCACTT TGAGCCCAAC 
GAGTACATCC ATTATGACCT GCTAGAGAAG AACATTAACA TTGTTCGCAA ACGACTGAAC 
CGGCCGCTGA CACTCTCGGA GAAGATTGTG TATGGACACC TGGATGACCC CGCCAGCCAG 
GAAATTGAGC GAGGCAAGTC GTACCTGCGG CTGCGGCCGG ACCGTGTGGC CATGCAGGAT 
GCGACGGCCC AGATGGCCAT GCTCCAGTTC ATCAGCAGCG GGCTGTCCAA GGTGGCTGTG 
CCATCCACCA TCCACTGTGA CCATCTGATT GAAGCCCAGG TTGGGGGCGA GAAAGACCTG 
CGCCGGGCCA AGGACATCAA CCAGGAAGTT TATAATTTCC TGGCAACTGC AGGTGCCAAA 
TATGGCGTGG GCTTCTGGAA GCCTGGATCT GGAATCATTC ACCAGATTAT TCTGGAAAAC 
TATGCGTACC CTGGTGTTCT TCTGATTGGC ACTGACTCCC ACACCCCCAA TGGTGGCGGC 
CTTGGGGGCA TCTGCATTGG AGTTGGGGGT GCCGATGCTG TGGATGTCAT GGCTGGGATC 
CCCTGGGAGC TGAAGTGCCC CAAGGTGATT GGCGTGAAGC TGACGGGCTC TCTCTCCGGT 
TGGTCCTCAC CCAAAGATGT GATCCTGAAG GTGGCAGGCA TCCTCACGGT GAAAGGTGGC 
ACAGGTGCAA TCGTGGAATA CCACGGGCCT GGTGTAGACT CCATCTCCTG CACTGGCATG 
GCGACAATCT GCAACATGGG TGCAGAAATT GGGGCCACCA CTTCCGTGTT CCCTTACAAC 
CACAGGATGA AGAAGTACCT GAGCAAGACC GGCCGGGAAG ACATTGCCAA TCTAGCTGAT 
GAATTCAAGG ATCACTTGGT GCCTGACCCT GGCTGCCATT ATGACCAACT AATTGAAATT 
AACCTCAGTG AGCTGAAGCC ACACATCAAT GGGCCCTTCA CCCCTGACCT GGCTCACCCT 
GTGGCAGAAG TGGGCAAGGT GGCAGAGAAG GAAGGATGGC CTCTGGACAT CCGAGTGGGT 
CTAATTGGTA GCTGCACCAA TTCAAGCTAT GAAGATATGG GGCGCTCAGC AGCTGTGGCC 
AAGCAGGCAC TGGCCCATGG CCTCAAGTGC AAGTCCCAGT TCACCATCAC TCCAGGTTCC 
GAGCAGATCC GCGCCACCAT TGAGCGGGAC GGCTATGCAC AGATCTTGAG GGATCTGGGT 
GGCATTGTCC TGGCCAATGC TTGTGGCCCC TGCATTGGCC AGTGGGACAG GAAGGACATC 
AAGAAGGGGG AGAAGAACAC AATCGTCACC TCCTACAACA GGAACTTCAC GGGCCGCAAC 
GACGCAAACC CCGAGACCCA TGCCTTTGTC ACGTCCCCAG AGATTGTCAC AGCCCTGGCC 
ATTGCGGGAA CCCTCAAGTT CAACCCAGAG ACCGACTACC TGACGGGCAC GGATGGCAAG 
AAGTTCAGGC TGGAGGCTCC GGATGCAGAT GAGCTTCCCA AAGGGGAGTT TGACCCAGGG 
CAGGACACCT ACCAGCACCC ACCCAAGGAC AGCAGCGGGC AGCATGTGGA CGTGAGCCCC 
ACCAGCCAGC GCCTGCAGCT CCTGGAGCCT TTTGACAAGT GGGATGGCAA GGACCTGGAG 
GACCTGCAGA TCCTCATCAA GGTCAAAGGG AAGTGTACCA CTGACCACAT CTCAGCTGCT 
GGCCCCTGGC TCAAGTTCCG TGGGCACTTG GATAACATCT CCAACAACCT GCTCATTGGT 
GCCATCAACA TTGAAAACGG CAAGGCCAAC TCCGTGCGCA ATGCCGTCAC TCAGGAGTTT 
GGCCCCGTCC CTGACACTGC CCGCTACTAC AAGAAACATG GCATCAGGTG GGTGGTGATC 
GGAGACGAGA ACTACGGCGA GGGCTCGAGC CGGGAGCATG CAGCTCTGGA GCCTCGCCAC 
CTTGGGGGCC GGGCCATCAT CACCAAGAGC TTTGCCAGGA TCCACGAGAC CAACCTGAAG 
AAACAGGGCC TGCTGCCTCT GACCTTCGCT GACCCGGCTG ACTACAACAA GATTCACCCT 
GTGGACAAGC TGACCATTCA GGGCCTGAAG GACTTCACCC CTGGCAAGCC CCTGAAGTGC 
ATCATCAAGC ACCCCAACGG GACCCAGGAG ACCATCCTCC TGAACCACAC CTTCAACGAG 
ACGCAGATTG AGTGGTTCCG CGCTGGCAGT GCCCTCAACA GAATGAAGGA ACTGCAACAG 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ACO2 ( NM_001098.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_001089.1 Homo sapiens aconitase 2 (ACO2), mRNA.

Price & Availability↑

CloneID	OHu18968
Clone ID Related Accession (Same CDS sequence)	NM_001098.2 , XM_024452250.1 , NM_001098.3
Accession Version	NM_001098.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2343bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-29
Organism	Homo sapiens(human)
Product	aconitate hydratase, mitochondrial precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL008582.11, BC026196.2 and BC014092.2. This sequence is a reference standard in the RefSeqGene project. On Nov 23, 2018 this sequence version replaced NM_001098.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660803.171951.1, SRR1660809.68762.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta MANE Ensembl match :: ENST00000216254.9/ ENSP00000216254.4 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCGCCCT ACAGCCTACT GGTGACTCGG CTGCAGAAAG CTCTGGGTGT GCGGCAGTAC 
CATGTGGCCT CAGTCCTGTG CCAACGGGCC AAGGTGGCGA TGAGCCACTT TGAGCCCAAC 
GAGTACATCC ATTATGACCT GCTAGAGAAG AACATTAACA TTGTTCGCAA ACGACTGAAC 
CGGCCGCTGA CACTCTCGGA GAAGATTGTG TATGGACACC TGGATGACCC CGCCAGCCAG 
GAAATTGAGC GAGGCAAGTC GTACCTGCGG CTGCGGCCGG ACCGTGTGGC CATGCAGGAT 
GCGACGGCCC AGATGGCCAT GCTCCAGTTC ATCAGCAGCG GGCTGTCCAA GGTGGCTGTG 
CCATCCACCA TCCACTGTGA CCATCTGATT GAAGCCCAGG TTGGGGGCGA GAAAGACCTG 
CGCCGGGCCA AGGACATCAA CCAGGAAGTT TATAATTTCC TGGCAACTGC AGGTGCCAAA 
TATGGCGTGG GCTTCTGGAA GCCTGGATCT GGAATCATTC ACCAGATTAT TCTGGAAAAC 
TATGCGTACC CTGGTGTTCT TCTGATTGGC ACTGACTCCC ACACCCCCAA TGGTGGCGGC 
CTTGGGGGCA TCTGCATTGG AGTTGGGGGT GCCGATGCTG TGGATGTCAT GGCTGGGATC 
CCCTGGGAGC TGAAGTGCCC CAAGGTGATT GGCGTGAAGC TGACGGGCTC TCTCTCCGGT 
TGGTCCTCAC CCAAAGATGT GATCCTGAAG GTGGCAGGCA TCCTCACGGT GAAAGGTGGC 
ACAGGTGCAA TCGTGGAATA CCACGGGCCT GGTGTAGACT CCATCTCCTG CACTGGCATG 
GCGACAATCT GCAACATGGG TGCAGAAATT GGGGCCACCA CTTCCGTGTT CCCTTACAAC 
CACAGGATGA AGAAGTACCT GAGCAAGACC GGCCGGGAAG ACATTGCCAA TCTAGCTGAT 
GAATTCAAGG ATCACTTGGT GCCTGACCCT GGCTGCCATT ATGACCAACT AATTGAAATT 
AACCTCAGTG AGCTGAAGCC ACACATCAAT GGGCCCTTCA CCCCTGACCT GGCTCACCCT 
GTGGCAGAAG TGGGCAAGGT GGCAGAGAAG GAAGGATGGC CTCTGGACAT CCGAGTGGGT 
CTAATTGGTA GCTGCACCAA TTCAAGCTAT GAAGATATGG GGCGCTCAGC AGCTGTGGCC 
AAGCAGGCAC TGGCCCATGG CCTCAAGTGC AAGTCCCAGT TCACCATCAC TCCAGGTTCC 
GAGCAGATCC GCGCCACCAT TGAGCGGGAC GGCTATGCAC AGATCTTGAG GGATCTGGGT 
GGCATTGTCC TGGCCAATGC TTGTGGCCCC TGCATTGGCC AGTGGGACAG GAAGGACATC 
AAGAAGGGGG AGAAGAACAC AATCGTCACC TCCTACAACA GGAACTTCAC GGGCCGCAAC 
GACGCAAACC CCGAGACCCA TGCCTTTGTC ACGTCCCCAG AGATTGTCAC AGCCCTGGCC 
ATTGCGGGAA CCCTCAAGTT CAACCCAGAG ACCGACTACC TGACGGGCAC GGATGGCAAG 
AAGTTCAGGC TGGAGGCTCC GGATGCAGAT GAGCTTCCCA AAGGGGAGTT TGACCCAGGG 
CAGGACACCT ACCAGCACCC ACCCAAGGAC AGCAGCGGGC AGCATGTGGA CGTGAGCCCC 
ACCAGCCAGC GCCTGCAGCT CCTGGAGCCT TTTGACAAGT GGGATGGCAA GGACCTGGAG 
GACCTGCAGA TCCTCATCAA GGTCAAAGGG AAGTGTACCA CTGACCACAT CTCAGCTGCT 
GGCCCCTGGC TCAAGTTCCG TGGGCACTTG GATAACATCT CCAACAACCT GCTCATTGGT 
GCCATCAACA TTGAAAACGG CAAGGCCAAC TCCGTGCGCA ATGCCGTCAC TCAGGAGTTT 
GGCCCCGTCC CTGACACTGC CCGCTACTAC AAGAAACATG GCATCAGGTG GGTGGTGATC 
GGAGACGAGA ACTACGGCGA GGGCTCGAGC CGGGAGCATG CAGCTCTGGA GCCTCGCCAC 
CTTGGGGGCC GGGCCATCAT CACCAAGAGC TTTGCCAGGA TCCACGAGAC CAACCTGAAG 
AAACAGGGCC TGCTGCCTCT GACCTTCGCT GACCCGGCTG ACTACAACAA GATTCACCCT 
GTGGACAAGC TGACCATTCA GGGCCTGAAG GACTTCACCC CTGGCAAGCC CCTGAAGTGC 
ATCATCAAGC ACCCCAACGG GACCCAGGAG ACCATCCTCC TGAACCACAC CTTCAACGAG 
ACGCAGATTG AGTGGTTCCG CGCTGGCAGT GCCCTCAACA GAATGAAGGA ACTGCAACAG 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001089.1
CDS	31..2373
Translation	MAPYSLLVTRLQKALGVRQYHVASVLCQRAKVAMSHFEPNEYIHYDLLEKNINIVRKRLNRPLTLSEKIVYGHLDDPASQEIERGKSYLRLRPDRVAMQDATAQMAMLQFISSGLSKVAVPSTIHCDHLIEAQVGGEKDLRRAKDINQEVYNFLATAGAKYGVGFWKPGSGIIHQIILENYAYPGVLLIGTDSHTPNGGGLGGICIGVGGADAVDVMAGIPWELKCPKVIGVKLTGSLSGWSSPKDVILKVAGILTVKGGTGAIVEYHGPGVDSISCTGMATICNMGAEIGATTSVFPYNHRMKKYLSKTGREDIANLADEFKDHLVPDPGCHYDQLIEINLSELKPHINGPFTPDLAHPVAEVGKVAEKEGWPLDIRVGLIGSCTNSSYEDMGRSAAVAKQALAHGLKCKSQFTITPGSEQIRATIERDGYAQILRDLGGIVLANACGPCIGQWDRKDIKKGEKNTIVTSYNRNFTGRNDANPETHAFVTSPEIVTALAIAGTLKFNPETDYLTGTDGKKFRLEAPDADELPKGEFDPGQDTYQHPPKDSSGQHVDVSPTSQRLQLLEPFDKWDGKDLEDLQILIKVKGKCTTDHISAAGPWLKFRGHLDNISNNLLIGAINIENGKANSVRNAVTQEFGPVPDTARYYKKHGIRWVVIGDENYGEGSSREHAALEPRHLGGRAIITKSFARIHETNLKKQGLLPLTFADPADYNKIHPVDKLTIQGLKDFTPGKPLKCIIKHPNGTQETILLNHTFNETQIEWFRAGSALNRMKELQQ

Target ORF information:

RefSeq Version	NM_001098.3
Organism	Homo sapiens(human)
Definition	Homo sapiens aconitase 2 (ACO2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001098.3

ORF Insert Sequence:

ATGGCGCCCT ACAGCCTACT GGTGACTCGG CTGCAGAAAG CTCTGGGTGT GCGGCAGTAC 
CATGTGGCCT CAGTCCTGTG CCAACGGGCC AAGGTGGCGA TGAGCCACTT TGAGCCCAAC 
GAGTACATCC ATTATGACCT GCTAGAGAAG AACATTAACA TTGTTCGCAA ACGACTGAAC 
CGGCCGCTGA CACTCTCGGA GAAGATTGTG TATGGACACC TGGATGACCC CGCCAGCCAG 
GAAATTGAGC GAGGCAAGTC GTACCTGCGG CTGCGGCCGG ACCGTGTGGC CATGCAGGAT 
GCGACGGCCC AGATGGCCAT GCTCCAGTTC ATCAGCAGCG GGCTGTCCAA GGTGGCTGTG 
CCATCCACCA TCCACTGTGA CCATCTGATT GAAGCCCAGG TTGGGGGCGA GAAAGACCTG 
CGCCGGGCCA AGGACATCAA CCAGGAAGTT TATAATTTCC TGGCAACTGC AGGTGCCAAA 
TATGGCGTGG GCTTCTGGAA GCCTGGATCT GGAATCATTC ACCAGATTAT TCTGGAAAAC 
TATGCGTACC CTGGTGTTCT TCTGATTGGC ACTGACTCCC ACACCCCCAA TGGTGGCGGC 
CTTGGGGGCA TCTGCATTGG AGTTGGGGGT GCCGATGCTG TGGATGTCAT GGCTGGGATC 
CCCTGGGAGC TGAAGTGCCC CAAGGTGATT GGCGTGAAGC TGACGGGCTC TCTCTCCGGT 
TGGTCCTCAC CCAAAGATGT GATCCTGAAG GTGGCAGGCA TCCTCACGGT GAAAGGTGGC 
ACAGGTGCAA TCGTGGAATA CCACGGGCCT GGTGTAGACT CCATCTCCTG CACTGGCATG 
GCGACAATCT GCAACATGGG TGCAGAAATT GGGGCCACCA CTTCCGTGTT CCCTTACAAC 
CACAGGATGA AGAAGTACCT GAGCAAGACC GGCCGGGAAG ACATTGCCAA TCTAGCTGAT 
GAATTCAAGG ATCACTTGGT GCCTGACCCT GGCTGCCATT ATGACCAACT AATTGAAATT 
AACCTCAGTG AGCTGAAGCC ACACATCAAT GGGCCCTTCA CCCCTGACCT GGCTCACCCT 
GTGGCAGAAG TGGGCAAGGT GGCAGAGAAG GAAGGATGGC CTCTGGACAT CCGAGTGGGT 
CTAATTGGTA GCTGCACCAA TTCAAGCTAT GAAGATATGG GGCGCTCAGC AGCTGTGGCC 
AAGCAGGCAC TGGCCCATGG CCTCAAGTGC AAGTCCCAGT TCACCATCAC TCCAGGTTCC 
GAGCAGATCC GCGCCACCAT TGAGCGGGAC GGCTATGCAC AGATCTTGAG GGATCTGGGT 
GGCATTGTCC TGGCCAATGC TTGTGGCCCC TGCATTGGCC AGTGGGACAG GAAGGACATC 
AAGAAGGGGG AGAAGAACAC AATCGTCACC TCCTACAACA GGAACTTCAC GGGCCGCAAC 
GACGCAAACC CCGAGACCCA TGCCTTTGTC ACGTCCCCAG AGATTGTCAC AGCCCTGGCC 
ATTGCGGGAA CCCTCAAGTT CAACCCAGAG ACCGACTACC TGACGGGCAC GGATGGCAAG 
AAGTTCAGGC TGGAGGCTCC GGATGCAGAT GAGCTTCCCA AAGGGGAGTT TGACCCAGGG 
CAGGACACCT ACCAGCACCC ACCCAAGGAC AGCAGCGGGC AGCATGTGGA CGTGAGCCCC 
ACCAGCCAGC GCCTGCAGCT CCTGGAGCCT TTTGACAAGT GGGATGGCAA GGACCTGGAG 
GACCTGCAGA TCCTCATCAA GGTCAAAGGG AAGTGTACCA CTGACCACAT CTCAGCTGCT 
GGCCCCTGGC TCAAGTTCCG TGGGCACTTG GATAACATCT CCAACAACCT GCTCATTGGT 
GCCATCAACA TTGAAAACGG CAAGGCCAAC TCCGTGCGCA ATGCCGTCAC TCAGGAGTTT 
GGCCCCGTCC CTGACACTGC CCGCTACTAC AAGAAACATG GCATCAGGTG GGTGGTGATC 
GGAGACGAGA ACTACGGCGA GGGCTCGAGC CGGGAGCATG CAGCTCTGGA GCCTCGCCAC 
CTTGGGGGCC GGGCCATCAT CACCAAGAGC TTTGCCAGGA TCCACGAGAC CAACCTGAAG 
AAACAGGGCC TGCTGCCTCT GACCTTCGCT GACCCGGCTG ACTACAACAA GATTCACCCT 
GTGGACAAGC TGACCATTCA GGGCCTGAAG GACTTCACCC CTGGCAAGCC CCTGAAGTGC 
ATCATCAAGC ACCCCAACGG GACCCAGGAG ACCATCCTCC TGAACCACAC CTTCAACGAG 
ACGCAGATTG AGTGGTTCCG CGCTGGCAGT GCCCTCAACA GAATGAAGGA ACTGCAACAG 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ACO2 ( XM_024452250.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_024308018.1 Homo sapiens aconitase 2 (ACO2), transcript variant X1, mRNA.

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CloneID	OHu18968
Clone ID Related Accession (Same CDS sequence)	NM_001098.2 , XM_024452250.1 , NM_001098.3
Accession Version	XM_024452250.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2343bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	aconitate hydratase, mitochondrial isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000022.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCGCCCT ACAGCCTACT GGTGACTCGG CTGCAGAAAG CTCTGGGTGT GCGGCAGTAC 
CATGTGGCCT CAGTCCTGTG CCAACGGGCC AAGGTGGCGA TGAGCCACTT TGAGCCCAAC 
GAGTACATCC ATTATGACCT GCTAGAGAAG AACATTAACA TTGTTCGCAA ACGACTGAAC 
CGGCCGCTGA CACTCTCGGA GAAGATTGTG TATGGACACC TGGATGACCC CGCCAGCCAG 
GAAATTGAGC GAGGCAAGTC GTACCTGCGG CTGCGGCCGG ACCGTGTGGC CATGCAGGAT 
GCGACGGCCC AGATGGCCAT GCTCCAGTTC ATCAGCAGCG GGCTGTCCAA GGTGGCTGTG 
CCATCCACCA TCCACTGTGA CCATCTGATT GAAGCCCAGG TTGGGGGCGA GAAAGACCTG 
CGCCGGGCCA AGGACATCAA CCAGGAAGTT TATAATTTCC TGGCAACTGC AGGTGCCAAA 
TATGGCGTGG GCTTCTGGAA GCCTGGATCT GGAATCATTC ACCAGATTAT TCTGGAAAAC 
TATGCGTACC CTGGTGTTCT TCTGATTGGC ACTGACTCCC ACACCCCCAA TGGTGGCGGC 
CTTGGGGGCA TCTGCATTGG AGTTGGGGGT GCCGATGCTG TGGATGTCAT GGCTGGGATC 
CCCTGGGAGC TGAAGTGCCC CAAGGTGATT GGCGTGAAGC TGACGGGCTC TCTCTCCGGT 
TGGTCCTCAC CCAAAGATGT GATCCTGAAG GTGGCAGGCA TCCTCACGGT GAAAGGTGGC 
ACAGGTGCAA TCGTGGAATA CCACGGGCCT GGTGTAGACT CCATCTCCTG CACTGGCATG 
GCGACAATCT GCAACATGGG TGCAGAAATT GGGGCCACCA CTTCCGTGTT CCCTTACAAC 
CACAGGATGA AGAAGTACCT GAGCAAGACC GGCCGGGAAG ACATTGCCAA TCTAGCTGAT 
GAATTCAAGG ATCACTTGGT GCCTGACCCT GGCTGCCATT ATGACCAACT AATTGAAATT 
AACCTCAGTG AGCTGAAGCC ACACATCAAT GGGCCCTTCA CCCCTGACCT GGCTCACCCT 
GTGGCAGAAG TGGGCAAGGT GGCAGAGAAG GAAGGATGGC CTCTGGACAT CCGAGTGGGT 
CTAATTGGTA GCTGCACCAA TTCAAGCTAT GAAGATATGG GGCGCTCAGC AGCTGTGGCC 
AAGCAGGCAC TGGCCCATGG CCTCAAGTGC AAGTCCCAGT TCACCATCAC TCCAGGTTCC 
GAGCAGATCC GCGCCACCAT TGAGCGGGAC GGCTATGCAC AGATCTTGAG GGATCTGGGT 
GGCATTGTCC TGGCCAATGC TTGTGGCCCC TGCATTGGCC AGTGGGACAG GAAGGACATC 
AAGAAGGGGG AGAAGAACAC AATCGTCACC TCCTACAACA GGAACTTCAC GGGCCGCAAC 
GACGCAAACC CCGAGACCCA TGCCTTTGTC ACGTCCCCAG AGATTGTCAC AGCCCTGGCC 
ATTGCGGGAA CCCTCAAGTT CAACCCAGAG ACCGACTACC TGACGGGCAC GGATGGCAAG 
AAGTTCAGGC TGGAGGCTCC GGATGCAGAT GAGCTTCCCA AAGGGGAGTT TGACCCAGGG 
CAGGACACCT ACCAGCACCC ACCCAAGGAC AGCAGCGGGC AGCATGTGGA CGTGAGCCCC 
ACCAGCCAGC GCCTGCAGCT CCTGGAGCCT TTTGACAAGT GGGATGGCAA GGACCTGGAG 
GACCTGCAGA TCCTCATCAA GGTCAAAGGG AAGTGTACCA CTGACCACAT CTCAGCTGCT 
GGCCCCTGGC TCAAGTTCCG TGGGCACTTG GATAACATCT CCAACAACCT GCTCATTGGT 
GCCATCAACA TTGAAAACGG CAAGGCCAAC TCCGTGCGCA ATGCCGTCAC TCAGGAGTTT 
GGCCCCGTCC CTGACACTGC CCGCTACTAC AAGAAACATG GCATCAGGTG GGTGGTGATC 
GGAGACGAGA ACTACGGCGA GGGCTCGAGC CGGGAGCATG CAGCTCTGGA GCCTCGCCAC 
CTTGGGGGCC GGGCCATCAT CACCAAGAGC TTTGCCAGGA TCCACGAGAC CAACCTGAAG 
AAACAGGGCC TGCTGCCTCT GACCTTCGCT GACCCGGCTG ACTACAACAA GATTCACCCT 
GTGGACAAGC TGACCATTCA GGGCCTGAAG GACTTCACCC CTGGCAAGCC CCTGAAGTGC 
ATCATCAAGC ACCCCAACGG GACCCAGGAG ACCATCCTCC TGAACCACAC CTTCAACGAG 
ACGCAGATTG AGTGGTTCCG CGCTGGCAGT GCCCTCAACA GAATGAAGGA ACTGCAACAG 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_024308018.1
CDS	283..2625
Translation	MAPYSLLVTRLQKALGVRQYHVASVLCQRAKVAMSHFEPNEYIHYDLLEKNINIVRKRLNRPLTLSEKIVYGHLDDPASQEIERGKSYLRLRPDRVAMQDATAQMAMLQFISSGLSKVAVPSTIHCDHLIEAQVGGEKDLRRAKDINQEVYNFLATAGAKYGVGFWKPGSGIIHQIILENYAYPGVLLIGTDSHTPNGGGLGGICIGVGGADAVDVMAGIPWELKCPKVIGVKLTGSLSGWSSPKDVILKVAGILTVKGGTGAIVEYHGPGVDSISCTGMATICNMGAEIGATTSVFPYNHRMKKYLSKTGREDIANLADEFKDHLVPDPGCHYDQLIEINLSELKPHINGPFTPDLAHPVAEVGKVAEKEGWPLDIRVGLIGSCTNSSYEDMGRSAAVAKQALAHGLKCKSQFTITPGSEQIRATIERDGYAQILRDLGGIVLANACGPCIGQWDRKDIKKGEKNTIVTSYNRNFTGRNDANPETHAFVTSPEIVTALAIAGTLKFNPETDYLTGTDGKKFRLEAPDADELPKGEFDPGQDTYQHPPKDSSGQHVDVSPTSQRLQLLEPFDKWDGKDLEDLQILIKVKGKCTTDHISAAGPWLKFRGHLDNISNNLLIGAINIENGKANSVRNAVTQEFGPVPDTARYYKKHGIRWVVIGDENYGEGSSREHAALEPRHLGGRAIITKSFARIHETNLKKQGLLPLTFADPADYNKIHPVDKLTIQGLKDFTPGKPLKCIIKHPNGTQETILLNHTFNETQIEWFRAGSALNRMKELQQ

Target ORF information:

RefSeq Version	XM_024452250.1
Organism	Homo sapiens(human)
Definition	Homo sapiens aconitase 2 (ACO2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_024452250.1

ORF Insert Sequence:

ATGGCGCCCT ACAGCCTACT GGTGACTCGG CTGCAGAAAG CTCTGGGTGT GCGGCAGTAC 
CATGTGGCCT CAGTCCTGTG CCAACGGGCC AAGGTGGCGA TGAGCCACTT TGAGCCCAAC 
GAGTACATCC ATTATGACCT GCTAGAGAAG AACATTAACA TTGTTCGCAA ACGACTGAAC 
CGGCCGCTGA CACTCTCGGA GAAGATTGTG TATGGACACC TGGATGACCC CGCCAGCCAG 
GAAATTGAGC GAGGCAAGTC GTACCTGCGG CTGCGGCCGG ACCGTGTGGC CATGCAGGAT 
GCGACGGCCC AGATGGCCAT GCTCCAGTTC ATCAGCAGCG GGCTGTCCAA GGTGGCTGTG 
CCATCCACCA TCCACTGTGA CCATCTGATT GAAGCCCAGG TTGGGGGCGA GAAAGACCTG 
CGCCGGGCCA AGGACATCAA CCAGGAAGTT TATAATTTCC TGGCAACTGC AGGTGCCAAA 
TATGGCGTGG GCTTCTGGAA GCCTGGATCT GGAATCATTC ACCAGATTAT TCTGGAAAAC 
TATGCGTACC CTGGTGTTCT TCTGATTGGC ACTGACTCCC ACACCCCCAA TGGTGGCGGC 
CTTGGGGGCA TCTGCATTGG AGTTGGGGGT GCCGATGCTG TGGATGTCAT GGCTGGGATC 
CCCTGGGAGC TGAAGTGCCC CAAGGTGATT GGCGTGAAGC TGACGGGCTC TCTCTCCGGT 
TGGTCCTCAC CCAAAGATGT GATCCTGAAG GTGGCAGGCA TCCTCACGGT GAAAGGTGGC 
ACAGGTGCAA TCGTGGAATA CCACGGGCCT GGTGTAGACT CCATCTCCTG CACTGGCATG 
GCGACAATCT GCAACATGGG TGCAGAAATT GGGGCCACCA CTTCCGTGTT CCCTTACAAC 
CACAGGATGA AGAAGTACCT GAGCAAGACC GGCCGGGAAG ACATTGCCAA TCTAGCTGAT 
GAATTCAAGG ATCACTTGGT GCCTGACCCT GGCTGCCATT ATGACCAACT AATTGAAATT 
AACCTCAGTG AGCTGAAGCC ACACATCAAT GGGCCCTTCA CCCCTGACCT GGCTCACCCT 
GTGGCAGAAG TGGGCAAGGT GGCAGAGAAG GAAGGATGGC CTCTGGACAT CCGAGTGGGT 
CTAATTGGTA GCTGCACCAA TTCAAGCTAT GAAGATATGG GGCGCTCAGC AGCTGTGGCC 
AAGCAGGCAC TGGCCCATGG CCTCAAGTGC AAGTCCCAGT TCACCATCAC TCCAGGTTCC 
GAGCAGATCC GCGCCACCAT TGAGCGGGAC GGCTATGCAC AGATCTTGAG GGATCTGGGT 
GGCATTGTCC TGGCCAATGC TTGTGGCCCC TGCATTGGCC AGTGGGACAG GAAGGACATC 
AAGAAGGGGG AGAAGAACAC AATCGTCACC TCCTACAACA GGAACTTCAC GGGCCGCAAC 
GACGCAAACC CCGAGACCCA TGCCTTTGTC ACGTCCCCAG AGATTGTCAC AGCCCTGGCC 
ATTGCGGGAA CCCTCAAGTT CAACCCAGAG ACCGACTACC TGACGGGCAC GGATGGCAAG 
AAGTTCAGGC TGGAGGCTCC GGATGCAGAT GAGCTTCCCA AAGGGGAGTT TGACCCAGGG 
CAGGACACCT ACCAGCACCC ACCCAAGGAC AGCAGCGGGC AGCATGTGGA CGTGAGCCCC 
ACCAGCCAGC GCCTGCAGCT CCTGGAGCCT TTTGACAAGT GGGATGGCAA GGACCTGGAG 
GACCTGCAGA TCCTCATCAA GGTCAAAGGG AAGTGTACCA CTGACCACAT CTCAGCTGCT 
GGCCCCTGGC TCAAGTTCCG TGGGCACTTG GATAACATCT CCAACAACCT GCTCATTGGT 
GCCATCAACA TTGAAAACGG CAAGGCCAAC TCCGTGCGCA ATGCCGTCAC TCAGGAGTTT 
GGCCCCGTCC CTGACACTGC CCGCTACTAC AAGAAACATG GCATCAGGTG GGTGGTGATC 
GGAGACGAGA ACTACGGCGA GGGCTCGAGC CGGGAGCATG CAGCTCTGGA GCCTCGCCAC 
CTTGGGGGCC GGGCCATCAT CACCAAGAGC TTTGCCAGGA TCCACGAGAC CAACCTGAAG 
AAACAGGGCC TGCTGCCTCT GACCTTCGCT GACCCGGCTG ACTACAACAA GATTCACCCT 
GTGGACAAGC TGACCATTCA GGGCCTGAAG GACTTCACCC CTGGCAAGCC CCTGAAGTGC 
ATCATCAAGC ACCCCAACGG GACCCAGGAG ACCATCCTCC TGAACCACAC CTTCAACGAG 
ACGCAGATTG AGTGGTTCCG CGCTGGCAGT GCCCTCAACA GAATGAAGGA ACTGCAACAG 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ACO2 ( XM_017028812.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016884301.1 Homo sapiens aconitase 2 (ACO2), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OHu93505
Clone ID Related Accession (Same CDS sequence)	XM_017028812.1
Accession Version	XM_017028812.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2244bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	aconitate hydratase, mitochondrial isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000022.11) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAGCCACT TTGAGCCCAA CGAGTACATC CATTATGACC TGCTAGAGAA GAACATTAAC 
ATTGTTCGCA AACGACTGAA CCGGCCGCTG ACACTCTCGG AGAAGATTGT GTATGGACAC 
CTGGATGACC CCGCCAGCCA GGAAATTGAG CGAGGCAAGT CGTACCTGCG GCTGCGGCCG 
GACCGTGTGG CCATGCAGGA TGCGACGGCC CAGATGGCCA TGCTCCAGTT CATCAGCAGC 
GGGCTGTCCA AGGTGGCTGT GCCATCCACC ATCCACTGTG ACCATCTGAT TGAAGCCCAG 
GTTGGGGGCG AGAAAGACCT GCGCCGGGCC AAGGACATCA ACCAGGAAGT TTATAATTTC 
CTGGCAACTG CAGGTGCCAA ATATGGCGTG GGCTTCTGGA AGCCTGGATC TGGAATCATT 
CACCAGATTA TTCTGGAAAA CTATGCGTAC CCTGGTGTTC TTCTGATTGG CACTGACTCC 
CACACCCCCA ATGGTGGCGG CCTTGGGGGC ATCTGCATTG GAGTTGGGGG TGCCGATGCT 
GTGGATGTCA TGGCTGGGAT CCCCTGGGAG CTGAAGTGCC CCAAGGTGAT TGGCGTGAAG 
CTGACGGGCT CTCTCTCCGG TTGGTCCTCA CCCAAAGATG TGATCCTGAA GGTGGCAGGC 
ATCCTCACGG TGAAAGGTGG CACAGGTGCA ATCGTGGAAT ACCACGGGCC TGGTGTAGAC 
TCCATCTCCT GCACTGGCAT GGCGACAATC TGCAACATGG GTGCAGAAAT TGGGGCCACC 
ACTTCCGTGT TCCCTTACAA CCACAGGATG AAGAAGTACC TGAGCAAGAC CGGCCGGGAA 
GACATTGCCA ATCTAGCTGA TGAATTCAAG GATCACTTGG TGCCTGACCC TGGCTGCCAT 
TATGACCAAC TAATTGAAAT TAACCTCAGT GAGCTGAAGC CACACATCAA TGGGCCCTTC 
ACCCCTGACC TGGCTCACCC TGTGGCAGAA GTGGGCAAGG TGGCAGAGAA GGAAGGATGG 
CCTCTGGACA TCCGAGTGGG TCTAATTGGT AGCTGCACCA ATTCAAGCTA TGAAGATATG 
GGGCGCTCAG CAGCTGTGGC CAAGCAGGCA CTGGCCCATG GCCTCAAGTG CAAGTCCCAG 
TTCACCATCA CTCCAGGTTC CGAGCAGATC CGCGCCACCA TTGAGCGGGA CGGCTATGCA 
CAGATCTTGA GGGATCTGGG TGGCATTGTC CTGGCCAATG CTTGTGGCCC CTGCATTGGC 
CAGTGGGACA GGAAGGACAT CAAGAAGGGG GAGAAGAACA CAATCGTCAC CTCCTACAAC 
AGGAACTTCA CGGGCCGCAA CGACGCAAAC CCCGAGACCC ATGCCTTTGT CACGTCCCCA 
GAGATTGTCA CAGCCCTGGC CATTGCGGGA ACCCTCAAGT TCAACCCAGA GACCGACTAC 
CTGACGGGCA CGGATGGCAA GAAGTTCAGG CTGGAGGCTC CGGATGCAGA TGAGCTTCCC 
AAAGGGGAGT TTGACCCAGG GCAGGACACC TACCAGCACC CACCCAAGGA CAGCAGCGGG 
CAGCATGTGG ACGTGAGCCC CACCAGCCAG CGCCTGCAGC TCCTGGAGCC TTTTGACAAG 
TGGGATGGCA AGGACCTGGA GGACCTGCAG ATCCTCATCA AGGTCAAAGG GAAGTGTACC 
ACTGACCACA TCTCAGCTGC TGGCCCCTGG CTCAAGTTCC GTGGGCACTT GGATAACATC 
TCCAACAACC TGCTCATTGG TGCCATCAAC ATTGAAAACG GCAAGGCCAA CTCCGTGCGC 
AATGCCGTCA CTCAGGAGTT TGGCCCCGTC CCTGACACTG CCCGCTACTA CAAGAAACAT 
GGCATCAGGT GGGTGGTGAT CGGAGACGAG AACTACGGCG AGGGCTCGAG CCGGGAGCAT 
GCAGCTCTGG AGCCTCGCCA CCTTGGGGGC CGGGCCATCA TCACCAAGAG CTTTGCCAGG 
ATCCACGAGA CCAACCTGAA GAAACAGGGC CTGCTGCCTC TGACCTTCGC TGACCCGGCT 
GACTACAACA AGATTCACCC TGTGGACAAG CTGACCATTC AGGGCCTGAA GGACTTCACC 
CCTGGCAAGC CCCTGAAGTG CATCATCAAG CACCCCAACG GGACCCAGGA GACCATCCTC 
CTGAACCACA CCTTCAACGA GACGCAGATT GAGTGGTTCC GCGCTGGCAG TGCCCTCAAC 
AGAATGAAGG AACTGCAACA GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016884301.1
CDS	436..2679
Translation	MSHFEPNEYIHYDLLEKNINIVRKRLNRPLTLSEKIVYGHLDDPASQEIERGKSYLRLRPDRVAMQDATAQMAMLQFISSGLSKVAVPSTIHCDHLIEAQVGGEKDLRRAKDINQEVYNFLATAGAKYGVGFWKPGSGIIHQIILENYAYPGVLLIGTDSHTPNGGGLGGICIGVGGADAVDVMAGIPWELKCPKVIGVKLTGSLSGWSSPKDVILKVAGILTVKGGTGAIVEYHGPGVDSISCTGMATICNMGAEIGATTSVFPYNHRMKKYLSKTGREDIANLADEFKDHLVPDPGCHYDQLIEINLSELKPHINGPFTPDLAHPVAEVGKVAEKEGWPLDIRVGLIGSCTNSSYEDMGRSAAVAKQALAHGLKCKSQFTITPGSEQIRATIERDGYAQILRDLGGIVLANACGPCIGQWDRKDIKKGEKNTIVTSYNRNFTGRNDANPETHAFVTSPEIVTALAIAGTLKFNPETDYLTGTDGKKFRLEAPDADELPKGEFDPGQDTYQHPPKDSSGQHVDVSPTSQRLQLLEPFDKWDGKDLEDLQILIKVKGKCTTDHISAAGPWLKFRGHLDNISNNLLIGAINIENGKANSVRNAVTQEFGPVPDTARYYKKHGIRWVVIGDENYGEGSSREHAALEPRHLGGRAIITKSFARIHETNLKKQGLLPLTFADPADYNKIHPVDKLTIQGLKDFTPGKPLKCIIKHPNGTQETILLNHTFNETQIEWFRAGSALNRMKELQQ

Target ORF information:

RefSeq Version	XM_017028812.1
Organism	Homo sapiens(human)
Definition	Homo sapiens aconitase 2 (ACO2), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017028812.1

ORF Insert Sequence:

ATGAGCCACT TTGAGCCCAA CGAGTACATC CATTATGACC TGCTAGAGAA GAACATTAAC 
ATTGTTCGCA AACGACTGAA CCGGCCGCTG ACACTCTCGG AGAAGATTGT GTATGGACAC 
CTGGATGACC CCGCCAGCCA GGAAATTGAG CGAGGCAAGT CGTACCTGCG GCTGCGGCCG 
GACCGTGTGG CCATGCAGGA TGCGACGGCC CAGATGGCCA TGCTCCAGTT CATCAGCAGC 
GGGCTGTCCA AGGTGGCTGT GCCATCCACC ATCCACTGTG ACCATCTGAT TGAAGCCCAG 
GTTGGGGGCG AGAAAGACCT GCGCCGGGCC AAGGACATCA ACCAGGAAGT TTATAATTTC 
CTGGCAACTG CAGGTGCCAA ATATGGCGTG GGCTTCTGGA AGCCTGGATC TGGAATCATT 
CACCAGATTA TTCTGGAAAA CTATGCGTAC CCTGGTGTTC TTCTGATTGG CACTGACTCC 
CACACCCCCA ATGGTGGCGG CCTTGGGGGC ATCTGCATTG GAGTTGGGGG TGCCGATGCT 
GTGGATGTCA TGGCTGGGAT CCCCTGGGAG CTGAAGTGCC CCAAGGTGAT TGGCGTGAAG 
CTGACGGGCT CTCTCTCCGG TTGGTCCTCA CCCAAAGATG TGATCCTGAA GGTGGCAGGC 
ATCCTCACGG TGAAAGGTGG CACAGGTGCA ATCGTGGAAT ACCACGGGCC TGGTGTAGAC 
TCCATCTCCT GCACTGGCAT GGCGACAATC TGCAACATGG GTGCAGAAAT TGGGGCCACC 
ACTTCCGTGT TCCCTTACAA CCACAGGATG AAGAAGTACC TGAGCAAGAC CGGCCGGGAA 
GACATTGCCA ATCTAGCTGA TGAATTCAAG GATCACTTGG TGCCTGACCC TGGCTGCCAT 
TATGACCAAC TAATTGAAAT TAACCTCAGT GAGCTGAAGC CACACATCAA TGGGCCCTTC 
ACCCCTGACC TGGCTCACCC TGTGGCAGAA GTGGGCAAGG TGGCAGAGAA GGAAGGATGG 
CCTCTGGACA TCCGAGTGGG TCTAATTGGT AGCTGCACCA ATTCAAGCTA TGAAGATATG 
GGGCGCTCAG CAGCTGTGGC CAAGCAGGCA CTGGCCCATG GCCTCAAGTG CAAGTCCCAG 
TTCACCATCA CTCCAGGTTC CGAGCAGATC CGCGCCACCA TTGAGCGGGA CGGCTATGCA 
CAGATCTTGA GGGATCTGGG TGGCATTGTC CTGGCCAATG CTTGTGGCCC CTGCATTGGC 
CAGTGGGACA GGAAGGACAT CAAGAAGGGG GAGAAGAACA CAATCGTCAC CTCCTACAAC 
AGGAACTTCA CGGGCCGCAA CGACGCAAAC CCCGAGACCC ATGCCTTTGT CACGTCCCCA 
GAGATTGTCA CAGCCCTGGC CATTGCGGGA ACCCTCAAGT TCAACCCAGA GACCGACTAC 
CTGACGGGCA CGGATGGCAA GAAGTTCAGG CTGGAGGCTC CGGATGCAGA TGAGCTTCCC 
AAAGGGGAGT TTGACCCAGG GCAGGACACC TACCAGCACC CACCCAAGGA CAGCAGCGGG 
CAGCATGTGG ACGTGAGCCC CACCAGCCAG CGCCTGCAGC TCCTGGAGCC TTTTGACAAG 
TGGGATGGCA AGGACCTGGA GGACCTGCAG ATCCTCATCA AGGTCAAAGG GAAGTGTACC 
ACTGACCACA TCTCAGCTGC TGGCCCCTGG CTCAAGTTCC GTGGGCACTT GGATAACATC 
TCCAACAACC TGCTCATTGG TGCCATCAAC ATTGAAAACG GCAAGGCCAA CTCCGTGCGC 
AATGCCGTCA CTCAGGAGTT TGGCCCCGTC CCTGACACTG CCCGCTACTA CAAGAAACAT 
GGCATCAGGT GGGTGGTGAT CGGAGACGAG AACTACGGCG AGGGCTCGAG CCGGGAGCAT 
GCAGCTCTGG AGCCTCGCCA CCTTGGGGGC CGGGCCATCA TCACCAAGAG CTTTGCCAGG 
ATCCACGAGA CCAACCTGAA GAAACAGGGC CTGCTGCCTC TGACCTTCGC TGACCCGGCT 
GACTACAACA AGATTCACCC TGTGGACAAG CTGACCATTC AGGGCCTGAA GGACTTCACC 
CCTGGCAAGC CCCTGAAGTG CATCATCAAG CACCCCAACG GGACCCAGGA GACCATCCTC 
CTGAACCACA CCTTCAACGA GACGCAGATT GAGTGGTTCC GCGCTGGCAG TGCCCTCAAC 
AGAATGAAGG AACTGCAACA GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Altered Aconitase 2 Activity in Huntington's Disease Peripheral Blood Cells and Mouse Model Striatum.
International journal of molecular sciences18(11)(2017 Nov)
Chen CM,Wu YR,Chang KH

Mitochondrial aconitase in Neurodegenerative disorders: role of a metabolism-related molecule in neurodegeneration.
Current drug targets(2017 Aug)
Khodagholi F,Shaerzadeh F,Montazeri F

Lymphocytic mitochondrial aconitase activity is reduced in Alzheimer's disease and mild cognitive impairment.
Journal of Alzheimer's disease : JAD44(2)649-60(2015)
Mangialasche F,Baglioni M,Cecchetti R,Kivipelto M,Ruggiero C,Piobbico D,Kussmaul L,Monastero R,Brancorsini S,Mecocci P

Mutations in the tricarboxylic acid cycle enzyme, aconitase 2, cause either isolated or syndromic optic neuropathy with encephalopathy and cerebellar atrophy.
Journal of medical genetics51(12)834-8(2014 Dec)
Metodiev MD,Gerber S,Hubert L,Delahodde A,Chretien D,G?rard X,Amati-Bonneau P,Giacomotto MC,Boddaert N,Kaminska A,Desguerre I,Amiel J,Rio M,Kaplan J,Munnich A,R?tig A,Rozet JM,Besmond C

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ACO2 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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