OPRK1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	OPRK1
Entrez Gene ID	4986
Full Name	opioid receptor kappa 1
Synonyms	K-OR-1,KOR,KOR-1,OPRK
General protein information	Preferred Names opioid receptor kappa 1 Names kappa-type opioid receptor Opiate receptor, kappa-1 kappa opioid receptor
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 8 Map Location: 8q11.23
Summary	This gene encodes an opioid receptor, which is a member of the 7 transmembrane-spanning G protein-coupled receptor family. It functions as a receptor for endogenous ligands, as well as a receptor for various synthetic opioids. Ligand binding results in inhibition of adenylate cyclase activity and neurotransmitter release. This opioid receptor plays a role in the perception of pain and mediating the hypolocomotor, analgesic and aversive actions of synthetic opioids. Variations in this gene have also been associated with alcohol dependence and opiate addiction. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. A recent study provided evidence for translational readthrough in this gene, and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Dec 2017].
Disorder MIM:	165196

mRNA and Protein(s)

mRNA	Protein	Name
NM_001318497.1	NP_001305426.1	kappa-type opioid receptor isoform 1x
NM_000912.4	NP_000903.2	kappa-type opioid receptor isoform 1
NM_000912.3	NP_000903.2	kappa-type opioid receptor isoform 1
NM_000912.5	NP_000903.2	kappa-type opioid receptor isoform 1
NM_001318497.2	NP_001305426.1	kappa-type opioid receptor isoform 1x
NM_001282904.1	NP_001269833.1	kappa-type opioid receptor isoform 2

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	OPRK1	XP_003311840.2
	OPRK1	XP_002805382.1
Xenopus tropicalis (tropical clawed frog)	oprk1	XP_002934159.2
Bos taurus (cattle)	OPRK1	NP_001039945.1
Mus musculus (house mouse)	Oprk1	NP_001191300.1
Gallus gallus (chicken)	OPRK1	XP_426087.2
Homo sapiens (human)	OPRK1	NP_000903.2
Canis lupus familiaris (dog)	OPRK1	XP_544080.2
Rattus norvegicus (Norway rat)	Oprk1	NP_058863.1
Danio rerio (zebrafish)	oprk1	NP_878306.1

Gene Ontology
Bibliography

Related articles in PubMed

Mechanism Governing Human Kappa-Opioid Receptor Expression under Desferrioxamine-Induced Hypoxic Mimic Condition in Neuronal NMB Cells.
Babcock J, Herrera A, Coricor G, Karch C, Liu AH, Rivera-Gines A, Ko JL
International journal of molecular sciences18(1)(2017 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Functional activity of Dynorphin 1-17 and fragments (1-6, 1-7 and 1-9) were screened over a range of concentrations against forskolin stimulated human embryonic kidney 293 (HEK) cells stably transfected with one of KOP, MOP or DOP
Title: The efficacy of Dynorphin fragments at the ?, ? and ? opioid receptor in transfected HEK cells and in an animal model of unilateral peripheral inflammation.

These results indicate that KOR can form a heterodimer with B2R and this leads to increased protein kinase A activity by the CREB signaling pathway, leading to a significant increase in cell proliferation.
Title: Novel signaling of dynorphin at ?-opioid receptor/bradykinin B2 receptor heterodimers.

Hypoxia inducible factor-1alpha (HIF-1alpha) siRNA knocked down the increase of endogenous HIF-1alpha messages and diminished the desferrioxamine (DFO)-induced increase of kappa-opioid receptor (hKOR) expression.
Title: Mechanism Governing Human Kappa-Opioid Receptor Expression under Desferrioxamine-Induced Hypoxic Mimic Condition in Neuronal NMB Cells.

that promoter fragments of OPRK1 and OPRM1 were able to upregulate gene expression with mild cognitive impairment
Title: Association of OPRK1 and OPRM1 methylation with mild cognitive impairment in Xinjiang Han and Uygur populations.

Heterodimerization of the kappa opioid receptor and neurotensin receptor 1 contributes to a novel beta-arrestin-2-signaling pathway.
Title: Heterodimerization of the kappa opioid receptor and neurotensin receptor 1 contributes to a novel ?-arrestin-2-biased pathway.

The following OPRK1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the OPRK1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu22468	NM_001282904.1 Latest version!	Homo sapiens opioid receptor kappa 1 (OPRK1), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
OHu25315	NM_000912.5 Latest version!	Homo sapiens opioid receptor kappa 1 (OPRK1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
OHu102712	NM_001318497.2 Latest version!	Homo sapiens opioid receptor kappa 1 (OPRK1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00
View Old Accession Versions >>
OHu25315	NM_000912.3	Homo sapiens opioid receptor, kappa 1 (OPRK1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
OHu25315	NM_000912.4	Homo sapiens opioid receptor kappa 1 (OPRK1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
OHu102712	NM_001318497.1	Homo sapiens opioid receptor kappa 1 (OPRK1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00
Hide Old Accession Versions >>

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

OPRK1 ( NM_001282904.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001269833.1 Homo sapiens opioid receptor kappa 1 (OPRK1), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu22468
Clone ID Related Accession (Same CDS sequence)	NM_001282904.1
Accession Version	NM_001282904.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 876bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-15
Organism	Homo sapiens(human)
Product	kappa-type opioid receptor isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC009646.12, AK310407.1 and BF061371.1. On Sep 21, 2013 this sequence version replaced XM_005251253.1. Transcript Variant: This variant (2) contains an additional exon in the mid-region, which results in translation initiation at an in-frame downstream start codon compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK310407.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA2142363, SAMEA2142853 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAAGACAG CAACCAACAT TTACATATTT AACCTGGCTT TGGCAGATGC TTTAGTTACT 
ACAACCATGC CCTTTCAGAG TACGGTCTAC TTGATGAATT CCTGGCCTTT TGGGGATGTG 
CTGTGCAAGA TAGTAATTTC CATTGATTAC TACAACATGT TCACCAGCAT CTTCACCTTG 
ACCATGATGA GCGTGGACCG CTACATTGCC GTGTGCCACC CCGTGAAGGC TTTGGACTTC 
CGCACACCCT TGAAGGCAAA GATCATCAAT ATCTGCATCT GGCTGCTGTC GTCATCTGTT 
GGCATCTCTG CAATAGTCCT TGGAGGCACC AAAGTCAGGG AAGACGTCGA TGTCATTGAG 
TGCTCCTTGC AGTTCCCAGA TGATGACTAC TCCTGGTGGG ACCTCTTCAT GAAGATCTGC 
GTCTTCATCT TTGCCTTCGT GATCCCTGTC CTCATCATCA TCGTCTGCTA CACCCTGATG 
ATCCTGCGTC TCAAGAGCGT CCGGCTCCTT TCTGGCTCCC GAGAGAAAGA TCGCAACCTG 
CGTAGGATCA CCAGACTGGT CCTGGTGGTG GTGGCAGTCT TCGTCGTCTG CTGGACTCCC 
ATTCACATAT TCATCCTGGT GGAGGCTCTG GGGAGCACCT CCCACAGCAC AGCTGCTCTC 
TCCAGCTATT ACTTCTGCAT CGCCTTAGGC TATACCAACA GTAGCCTGAA TCCCATTCTC 
TACGCCTTTC TTGATGAAAA CTTCAAGCGG TGTTTCCGGG ACTTCTGCTT TCCACTGAAG 
ATGAGGATGG AGCGGCAGAG CACTAGCAGA GTCCGAAATA CAGTTCAGGA TCCTGCTTAC 
CTGAGGGACA TCGATGGGAT GAATAAACCA GTATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001269833.1
CDS	740..1615
Translation	MKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV

Target ORF information:

RefSeq Version	NM_001282904.1
Organism	Homo sapiens(human)
Definition	Homo sapiens opioid receptor kappa 1 (OPRK1), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001282904.1

ORF Insert Sequence:

ATGAAGACAG CAACCAACAT TTACATATTT AACCTGGCTT TGGCAGATGC TTTAGTTACT 
ACAACCATGC CCTTTCAGAG TACGGTCTAC TTGATGAATT CCTGGCCTTT TGGGGATGTG 
CTGTGCAAGA TAGTAATTTC CATTGATTAC TACAACATGT TCACCAGCAT CTTCACCTTG 
ACCATGATGA GCGTGGACCG CTACATTGCC GTGTGCCACC CCGTGAAGGC TTTGGACTTC 
CGCACACCCT TGAAGGCAAA GATCATCAAT ATCTGCATCT GGCTGCTGTC GTCATCTGTT 
GGCATCTCTG CAATAGTCCT TGGAGGCACC AAAGTCAGGG AAGACGTCGA TGTCATTGAG 
TGCTCCTTGC AGTTCCCAGA TGATGACTAC TCCTGGTGGG ACCTCTTCAT GAAGATCTGC 
GTCTTCATCT TTGCCTTCGT GATCCCTGTC CTCATCATCA TCGTCTGCTA CACCCTGATG 
ATCCTGCGTC TCAAGAGCGT CCGGCTCCTT TCTGGCTCCC GAGAGAAAGA TCGCAACCTG 
CGTAGGATCA CCAGACTGGT CCTGGTGGTG GTGGCAGTCT TCGTCGTCTG CTGGACTCCC 
ATTCACATAT TCATCCTGGT GGAGGCTCTG GGGAGCACCT CCCACAGCAC AGCTGCTCTC 
TCCAGCTATT ACTTCTGCAT CGCCTTAGGC TATACCAACA GTAGCCTGAA TCCCATTCTC 
TACGCCTTTC TTGATGAAAA CTTCAAGCGG TGTTTCCGGG ACTTCTGCTT TCCACTGAAG 
ATGAGGATGG AGCGGCAGAG CACTAGCAGA GTCCGAAATA CAGTTCAGGA TCCTGCTTAC 
CTGAGGGACA TCGATGGGAT GAATAAACCA GTATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

OPRK1 ( NM_000912.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_000903.2 Homo sapiens opioid receptor kappa 1 (OPRK1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu25315
Clone ID Related Accession (Same CDS sequence)	NM_000912.4 , NM_000912.3 , NM_000912.5
Accession Version	NM_000912.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1143bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-17
Organism	Homo sapiens(human)
Product	kappa-type opioid receptor isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AY466378.1, U17298.1, BC099912.1, DA264471.1 and AK023198.1. On Jan 8, 2016 this sequence version replaced NM_000912.3. Transcript Variant: This variant (1) represents the predominant transcript and encodes two isoforms, which result from the use of alternative in-frame translation termination codons. The shorter isoform (1) results from translation termination at the upstream UGA stop codon, while the longer isoform (1x) results from UGA stop codon readthrough to the downstream UGA termination codon (nt . This RefSeq represents the shorter isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC099912.1, SRR1803612.57217.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145743, SAMEA2154665 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGACTCCC CGATCCAGAT CTTCCGCGGG GAGCCGGGCC CTACCTGCGC CCCGAGCGCC 
TGCCTGCCCC CCAACAGCAG CGCCTGGTTT CCCGGCTGGG CCGAGCCCGA CAGCAACGGC 
AGCGCCGGCT CGGAGGACGC GCAGCTGGAG CCCGCGCACA TCTCCCCGGC CATCCCGGTC 
ATCATCACGG CGGTCTACTC CGTAGTGTTC GTCGTGGGCT TGGTGGGCAA CTCGCTGGTC 
ATGTTCGTGA TCATCCGATA CACAAAGATG AAGACAGCAA CCAACATTTA CATATTTAAC 
CTGGCTTTGG CAGATGCTTT AGTTACTACA ACCATGCCCT TTCAGAGTAC GGTCTACTTG 
ATGAATTCCT GGCCTTTTGG GGATGTGCTG TGCAAGATAG TAATTTCCAT TGATTACTAC 
AACATGTTCA CCAGCATCTT CACCTTGACC ATGATGAGCG TGGACCGCTA CATTGCCGTG 
TGCCACCCCG TGAAGGCTTT GGACTTCCGC ACACCCTTGA AGGCAAAGAT CATCAATATC 
TGCATCTGGC TGCTGTCGTC ATCTGTTGGC ATCTCTGCAA TAGTCCTTGG AGGCACCAAA 
GTCAGGGAAG ACGTCGATGT CATTGAGTGC TCCTTGCAGT TCCCAGATGA TGACTACTCC 
TGGTGGGACC TCTTCATGAA GATCTGCGTC TTCATCTTTG CCTTCGTGAT CCCTGTCCTC 
ATCATCATCG TCTGCTACAC CCTGATGATC CTGCGTCTCA AGAGCGTCCG GCTCCTTTCT 
GGCTCCCGAG AGAAAGATCG CAACCTGCGT AGGATCACCA GACTGGTCCT GGTGGTGGTG 
GCAGTCTTCG TCGTCTGCTG GACTCCCATT CACATATTCA TCCTGGTGGA GGCTCTGGGG 
AGCACCTCCC ACAGCACAGC TGCTCTCTCC AGCTATTACT TCTGCATCGC CTTAGGCTAT 
ACCAACAGTA GCCTGAATCC CATTCTCTAC GCCTTTCTTG ATGAAAACTT CAAGCGGTGT 
TTCCGGGACT TCTGCTTTCC ACTGAAGATG AGGATGGAGC GGCAGAGCAC TAGCAGAGTC 
CGAAATACAG TTCAGGATCC TGCTTACCTG AGGGACATCG ATGGGATGAA TAAACCAGTA 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000903.2
CDS	299..1441
Translation	MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV

Target ORF information:

RefSeq Version	NM_000912.4
Organism	Homo sapiens(human)
Definition	Homo sapiens opioid receptor kappa 1 (OPRK1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000912.4

ORF Insert Sequence:

ATGGACTCCC CGATCCAGAT CTTCCGCGGG GAGCCGGGCC CTACCTGCGC CCCGAGCGCC 
TGCCTGCCCC CCAACAGCAG CGCCTGGTTT CCCGGCTGGG CCGAGCCCGA CAGCAACGGC 
AGCGCCGGCT CGGAGGACGC GCAGCTGGAG CCCGCGCACA TCTCCCCGGC CATCCCGGTC 
ATCATCACGG CGGTCTACTC CGTAGTGTTC GTCGTGGGCT TGGTGGGCAA CTCGCTGGTC 
ATGTTCGTGA TCATCCGATA CACAAAGATG AAGACAGCAA CCAACATTTA CATATTTAAC 
CTGGCTTTGG CAGATGCTTT AGTTACTACA ACCATGCCCT TTCAGAGTAC GGTCTACTTG 
ATGAATTCCT GGCCTTTTGG GGATGTGCTG TGCAAGATAG TAATTTCCAT TGATTACTAC 
AACATGTTCA CCAGCATCTT CACCTTGACC ATGATGAGCG TGGACCGCTA CATTGCCGTG 
TGCCACCCCG TGAAGGCTTT GGACTTCCGC ACACCCTTGA AGGCAAAGAT CATCAATATC 
TGCATCTGGC TGCTGTCGTC ATCTGTTGGC ATCTCTGCAA TAGTCCTTGG AGGCACCAAA 
GTCAGGGAAG ACGTCGATGT CATTGAGTGC TCCTTGCAGT TCCCAGATGA TGACTACTCC 
TGGTGGGACC TCTTCATGAA GATCTGCGTC TTCATCTTTG CCTTCGTGAT CCCTGTCCTC 
ATCATCATCG TCTGCTACAC CCTGATGATC CTGCGTCTCA AGAGCGTCCG GCTCCTTTCT 
GGCTCCCGAG AGAAAGATCG CAACCTGCGT AGGATCACCA GACTGGTCCT GGTGGTGGTG 
GCAGTCTTCG TCGTCTGCTG GACTCCCATT CACATATTCA TCCTGGTGGA GGCTCTGGGG 
AGCACCTCCC ACAGCACAGC TGCTCTCTCC AGCTATTACT TCTGCATCGC CTTAGGCTAT 
ACCAACAGTA GCCTGAATCC CATTCTCTAC GCCTTTCTTG ATGAAAACTT CAAGCGGTGT 
TTCCGGGACT TCTGCTTTCC ACTGAAGATG AGGATGGAGC GGCAGAGCAC TAGCAGAGTC 
CGAAATACAG TTCAGGATCC TGCTTACCTG AGGGACATCG ATGGGATGAA TAAACCAGTA 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

OPRK1 ( NM_000912.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_000903.2 Homo sapiens opioid receptor, kappa 1 (OPRK1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu25315
Clone ID Related Accession (Same CDS sequence)	NM_000912.4 , NM_000912.3 , NM_000912.5
Accession Version	NM_000912.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1143bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-03-14
Organism	Homo sapiens(Human)
Product	kappa-type opioid receptor isoform 1
Comment

ATGGACTCCC CGATCCAGAT CTTCCGCGGG GAGCCGGGCC CTACCTGCGC CCCGAGCGCC 
TGCCTGCCCC CCAACAGCAG CGCCTGGTTT CCCGGCTGGG CCGAGCCCGA CAGCAACGGC 
AGCGCCGGCT CGGAGGACGC GCAGCTGGAG CCCGCGCACA TCTCCCCGGC CATCCCGGTC 
ATCATCACGG CGGTCTACTC CGTAGTGTTC GTCGTGGGCT TGGTGGGCAA CTCGCTGGTC 
ATGTTCGTGA TCATCCGATA CACAAAGATG AAGACAGCAA CCAACATTTA CATATTTAAC 
CTGGCTTTGG CAGATGCTTT AGTTACTACA ACCATGCCCT TTCAGAGTAC GGTCTACTTG 
ATGAATTCCT GGCCTTTTGG GGATGTGCTG TGCAAGATAG TAATTTCCAT TGATTACTAC 
AACATGTTCA CCAGCATCTT CACCTTGACC ATGATGAGCG TGGACCGCTA CATTGCCGTG 
TGCCACCCCG TGAAGGCTTT GGACTTCCGC ACACCCTTGA AGGCAAAGAT CATCAATATC 
TGCATCTGGC TGCTGTCGTC ATCTGTTGGC ATCTCTGCAA TAGTCCTTGG AGGCACCAAA 
GTCAGGGAAG ACGTCGATGT CATTGAGTGC TCCTTGCAGT TCCCAGATGA TGACTACTCC 
TGGTGGGACC TCTTCATGAA GATCTGCGTC TTCATCTTTG CCTTCGTGAT CCCTGTCCTC 
ATCATCATCG TCTGCTACAC CCTGATGATC CTGCGTCTCA AGAGCGTCCG GCTCCTTTCT 
GGCTCCCGAG AGAAAGATCG CAACCTGCGT AGGATCACCA GACTGGTCCT GGTGGTGGTG 
GCAGTCTTCG TCGTCTGCTG GACTCCCATT CACATATTCA TCCTGGTGGA GGCTCTGGGG 
AGCACCTCCC ACAGCACAGC TGCTCTCTCC AGCTATTACT TCTGCATCGC CTTAGGCTAT 
ACCAACAGTA GCCTGAATCC CATTCTCTAC GCCTTTCTTG ATGAAAACTT CAAGCGGTGT 
TTCCGGGACT TCTGCTTTCC ACTGAAGATG AGGATGGAGC GGCAGAGCAC TAGCAGAGTC 
CGAAATACAG TTCAGGATCC TGCTTACCTG AGGGACATCG ATGGGATGAA TAAACCAGTA 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000903.2
Translation	MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV

Target ORF information:

RefSeq Version	NM_000912.3
Organism	Homo sapiens(Human)
Definition	Homo sapiens opioid receptor, kappa 1 (OPRK1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000912.3

ORF Insert Sequence:

ATGGACTCCC CGATCCAGAT CTTCCGCGGG GAGCCGGGCC CTACCTGCGC CCCGAGCGCC 
TGCCTGCCCC CCAACAGCAG CGCCTGGTTT CCCGGCTGGG CCGAGCCCGA CAGCAACGGC 
AGCGCCGGCT CGGAGGACGC GCAGCTGGAG CCCGCGCACA TCTCCCCGGC CATCCCGGTC 
ATCATCACGG CGGTCTACTC CGTAGTGTTC GTCGTGGGCT TGGTGGGCAA CTCGCTGGTC 
ATGTTCGTGA TCATCCGATA CACAAAGATG AAGACAGCAA CCAACATTTA CATATTTAAC 
CTGGCTTTGG CAGATGCTTT AGTTACTACA ACCATGCCCT TTCAGAGTAC GGTCTACTTG 
ATGAATTCCT GGCCTTTTGG GGATGTGCTG TGCAAGATAG TAATTTCCAT TGATTACTAC 
AACATGTTCA CCAGCATCTT CACCTTGACC ATGATGAGCG TGGACCGCTA CATTGCCGTG 
TGCCACCCCG TGAAGGCTTT GGACTTCCGC ACACCCTTGA AGGCAAAGAT CATCAATATC 
TGCATCTGGC TGCTGTCGTC ATCTGTTGGC ATCTCTGCAA TAGTCCTTGG AGGCACCAAA 
GTCAGGGAAG ACGTCGATGT CATTGAGTGC TCCTTGCAGT TCCCAGATGA TGACTACTCC 
TGGTGGGACC TCTTCATGAA GATCTGCGTC TTCATCTTTG CCTTCGTGAT CCCTGTCCTC 
ATCATCATCG TCTGCTACAC CCTGATGATC CTGCGTCTCA AGAGCGTCCG GCTCCTTTCT 
GGCTCCCGAG AGAAAGATCG CAACCTGCGT AGGATCACCA GACTGGTCCT GGTGGTGGTG 
GCAGTCTTCG TCGTCTGCTG GACTCCCATT CACATATTCA TCCTGGTGGA GGCTCTGGGG 
AGCACCTCCC ACAGCACAGC TGCTCTCTCC AGCTATTACT TCTGCATCGC CTTAGGCTAT 
ACCAACAGTA GCCTGAATCC CATTCTCTAC GCCTTTCTTG ATGAAAACTT CAAGCGGTGT 
TTCCGGGACT TCTGCTTTCC ACTGAAGATG AGGATGGAGC GGCAGAGCAC TAGCAGAGTC 
CGAAATACAG TTCAGGATCC TGCTTACCTG AGGGACATCG ATGGGATGAA TAAACCAGTA 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

OPRK1 ( NM_000912.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_000903.2 Homo sapiens opioid receptor kappa 1 (OPRK1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu25315
Clone ID Related Accession (Same CDS sequence)	NM_000912.4 , NM_000912.3 , NM_000912.5
Accession Version	NM_000912.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1143bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-16
Organism	Homo sapiens(human)
Product	kappa-type opioid receptor isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AY466378.1, U17298.1, BC099912.1, DA264471.1 and AK023198.1. On Nov 23, 2018 this sequence version replaced NM_000912.4. Transcript Variant: This variant (1) represents the predominant transcript and encodes two isoforms, which result from the use of alternative in-frame translation termination codons. The shorter isoform (1) results from translation termination at the upstream UGA stop codon, while the longer isoform (1x) results from UGA stop codon readthrough to the downstream UGA termination codon (nt . This RefSeq represents the shorter isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC099912.1, SRR1803612.57217.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145743, SAMEA2154665 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000265572.8/ ENSP00000265572.3 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGACTCCC CGATCCAGAT CTTCCGCGGG GAGCCGGGCC CTACCTGCGC CCCGAGCGCC 
TGCCTGCCCC CCAACAGCAG CGCCTGGTTT CCCGGCTGGG CCGAGCCCGA CAGCAACGGC 
AGCGCCGGCT CGGAGGACGC GCAGCTGGAG CCCGCGCACA TCTCCCCGGC CATCCCGGTC 
ATCATCACGG CGGTCTACTC CGTAGTGTTC GTCGTGGGCT TGGTGGGCAA CTCGCTGGTC 
ATGTTCGTGA TCATCCGATA CACAAAGATG AAGACAGCAA CCAACATTTA CATATTTAAC 
CTGGCTTTGG CAGATGCTTT AGTTACTACA ACCATGCCCT TTCAGAGTAC GGTCTACTTG 
ATGAATTCCT GGCCTTTTGG GGATGTGCTG TGCAAGATAG TAATTTCCAT TGATTACTAC 
AACATGTTCA CCAGCATCTT CACCTTGACC ATGATGAGCG TGGACCGCTA CATTGCCGTG 
TGCCACCCCG TGAAGGCTTT GGACTTCCGC ACACCCTTGA AGGCAAAGAT CATCAATATC 
TGCATCTGGC TGCTGTCGTC ATCTGTTGGC ATCTCTGCAA TAGTCCTTGG AGGCACCAAA 
GTCAGGGAAG ACGTCGATGT CATTGAGTGC TCCTTGCAGT TCCCAGATGA TGACTACTCC 
TGGTGGGACC TCTTCATGAA GATCTGCGTC TTCATCTTTG CCTTCGTGAT CCCTGTCCTC 
ATCATCATCG TCTGCTACAC CCTGATGATC CTGCGTCTCA AGAGCGTCCG GCTCCTTTCT 
GGCTCCCGAG AGAAAGATCG CAACCTGCGT AGGATCACCA GACTGGTCCT GGTGGTGGTG 
GCAGTCTTCG TCGTCTGCTG GACTCCCATT CACATATTCA TCCTGGTGGA GGCTCTGGGG 
AGCACCTCCC ACAGCACAGC TGCTCTCTCC AGCTATTACT TCTGCATCGC CTTAGGCTAT 
ACCAACAGTA GCCTGAATCC CATTCTCTAC GCCTTTCTTG ATGAAAACTT CAAGCGGTGT 
TTCCGGGACT TCTGCTTTCC ACTGAAGATG AGGATGGAGC GGCAGAGCAC TAGCAGAGTC 
CGAAATACAG TTCAGGATCC TGCTTACCTG AGGGACATCG ATGGGATGAA TAAACCAGTA 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000903.2
CDS	239..1381
Translation	MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV

Target ORF information:

RefSeq Version	NM_000912.5
Organism	Homo sapiens(human)
Definition	Homo sapiens opioid receptor kappa 1 (OPRK1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000912.5

ORF Insert Sequence:

ATGGACTCCC CGATCCAGAT CTTCCGCGGG GAGCCGGGCC CTACCTGCGC CCCGAGCGCC 
TGCCTGCCCC CCAACAGCAG CGCCTGGTTT CCCGGCTGGG CCGAGCCCGA CAGCAACGGC 
AGCGCCGGCT CGGAGGACGC GCAGCTGGAG CCCGCGCACA TCTCCCCGGC CATCCCGGTC 
ATCATCACGG CGGTCTACTC CGTAGTGTTC GTCGTGGGCT TGGTGGGCAA CTCGCTGGTC 
ATGTTCGTGA TCATCCGATA CACAAAGATG AAGACAGCAA CCAACATTTA CATATTTAAC 
CTGGCTTTGG CAGATGCTTT AGTTACTACA ACCATGCCCT TTCAGAGTAC GGTCTACTTG 
ATGAATTCCT GGCCTTTTGG GGATGTGCTG TGCAAGATAG TAATTTCCAT TGATTACTAC 
AACATGTTCA CCAGCATCTT CACCTTGACC ATGATGAGCG TGGACCGCTA CATTGCCGTG 
TGCCACCCCG TGAAGGCTTT GGACTTCCGC ACACCCTTGA AGGCAAAGAT CATCAATATC 
TGCATCTGGC TGCTGTCGTC ATCTGTTGGC ATCTCTGCAA TAGTCCTTGG AGGCACCAAA 
GTCAGGGAAG ACGTCGATGT CATTGAGTGC TCCTTGCAGT TCCCAGATGA TGACTACTCC 
TGGTGGGACC TCTTCATGAA GATCTGCGTC TTCATCTTTG CCTTCGTGAT CCCTGTCCTC 
ATCATCATCG TCTGCTACAC CCTGATGATC CTGCGTCTCA AGAGCGTCCG GCTCCTTTCT 
GGCTCCCGAG AGAAAGATCG CAACCTGCGT AGGATCACCA GACTGGTCCT GGTGGTGGTG 
GCAGTCTTCG TCGTCTGCTG GACTCCCATT CACATATTCA TCCTGGTGGA GGCTCTGGGG 
AGCACCTCCC ACAGCACAGC TGCTCTCTCC AGCTATTACT TCTGCATCGC CTTAGGCTAT 
ACCAACAGTA GCCTGAATCC CATTCTCTAC GCCTTTCTTG ATGAAAACTT CAAGCGGTGT 
TTCCGGGACT TCTGCTTTCC ACTGAAGATG AGGATGGAGC GGCAGAGCAC TAGCAGAGTC 
CGAAATACAG TTCAGGATCC TGCTTACCTG AGGGACATCG ATGGGATGAA TAAACCAGTA 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

OPRK1 ( NM_001318497.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001305426.1 Homo sapiens opioid receptor kappa 1 (OPRK1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu102712
Clone ID Related Accession (Same CDS sequence)	NM_001318497.1 , NM_001318497.2
Accession Version	NM_001318497.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1230bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-03-03
Organism	Homo sapiens(human)
Product	kappa-type opioid receptor isoform 1x
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AY466378.1, U17298.1, BC099912.1, DA264471.1 and AK023198.1. Transcript Variant: This variant (1) represents the predominant transcript and encodes two isoforms, which result from the use of alternative in-frame translation termination codons. The shorter isoform (1) results from translation termination at the upstream UGA stop codon, while the longer isoform (1x) results from UGA stop codon readthrough to the downstream UGA termination codon. This RefSeq represents the longer, C-terminally extended isoform (1x). As the UGA stop codon has been reported to specify several alternative amino acids (tryptophan, cysteine, arginine and serine), the location of the upstream UGA stop codon in the longer isoform is denoted by an 'X'. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC099912.1, SRR1803612.57217.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145743, SAMEA2154665 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## stop codon readthrough :: PMID: 25013167 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGACTCCC CGATCCAGAT CTTCCGCGGG GAGCCGGGCC CTACCTGCGC CCCGAGCGCC 
TGCCTGCCCC CCAACAGCAG CGCCTGGTTT CCCGGCTGGG CCGAGCCCGA CAGCAACGGC 
AGCGCCGGCT CGGAGGACGC GCAGCTGGAG CCCGCGCACA TCTCCCCGGC CATCCCGGTC 
ATCATCACGG CGGTCTACTC CGTAGTGTTC GTCGTGGGCT TGGTGGGCAA CTCGCTGGTC 
ATGTTCGTGA TCATCCGATA CACAAAGATG AAGACAGCAA CCAACATTTA CATATTTAAC 
CTGGCTTTGG CAGATGCTTT AGTTACTACA ACCATGCCCT TTCAGAGTAC GGTCTACTTG 
ATGAATTCCT GGCCTTTTGG GGATGTGCTG TGCAAGATAG TAATTTCCAT TGATTACTAC 
AACATGTTCA CCAGCATCTT CACCTTGACC ATGATGAGCG TGGACCGCTA CATTGCCGTG 
TGCCACCCCG TGAAGGCTTT GGACTTCCGC ACACCCTTGA AGGCAAAGAT CATCAATATC 
TGCATCTGGC TGCTGTCGTC ATCTGTTGGC ATCTCTGCAA TAGTCCTTGG AGGCACCAAA 
GTCAGGGAAG ACGTCGATGT CATTGAGTGC TCCTTGCAGT TCCCAGATGA TGACTACTCC 
TGGTGGGACC TCTTCATGAA GATCTGCGTC TTCATCTTTG CCTTCGTGAT CCCTGTCCTC 
ATCATCATCG TCTGCTACAC CCTGATGATC CTGCGTCTCA AGAGCGTCCG GCTCCTTTCT 
GGCTCCCGAG AGAAAGATCG CAACCTGCGT AGGATCACCA GACTGGTCCT GGTGGTGGTG 
GCAGTCTTCG TCGTCTGCTG GACTCCCATT CACATATTCA TCCTGGTGGA GGCTCTGGGG 
AGCACCTCCC ACAGCACAGC TGCTCTCTCC AGCTATTACT TCTGCATCGC CTTAGGCTAT 
ACCAACAGTA GCCTGAATCC CATTCTCTAC GCCTTTCTTG ATGAAAACTT CAAGCGGTGT 
TTCCGGGACT TCTGCTTTCC ACTGAAGATG AGGATGGAGC GGCAGAGCAC TAGCAGAGTC 
CGAAATACAG TTCAGGATCC TGCTTACCTG AGGGACATCG ATGGGATGAA TAAACCAGTA 
TGACTAGTCG TGGAGATGTC TTCGTACAGT TCTTCGGGAA GAGAGGAGTT CAATGATCTA 
GGTTTAACTC AGATCACTAC TGCAGTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001305426.1
CDS	299..1528
Translation	MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV*LVVEMSSYSSSGREEFNDLGLTQITTAV

Target ORF information:

RefSeq Version	NM_001318497.1
Organism	Homo sapiens(human)
Definition	Homo sapiens opioid receptor kappa 1 (OPRK1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001318497.1

ORF Insert Sequence:

ATGGACTCCC CGATCCAGAT CTTCCGCGGG GAGCCGGGCC CTACCTGCGC CCCGAGCGCC 
TGCCTGCCCC CCAACAGCAG CGCCTGGTTT CCCGGCTGGG CCGAGCCCGA CAGCAACGGC 
AGCGCCGGCT CGGAGGACGC GCAGCTGGAG CCCGCGCACA TCTCCCCGGC CATCCCGGTC 
ATCATCACGG CGGTCTACTC CGTAGTGTTC GTCGTGGGCT TGGTGGGCAA CTCGCTGGTC 
ATGTTCGTGA TCATCCGATA CACAAAGATG AAGACAGCAA CCAACATTTA CATATTTAAC 
CTGGCTTTGG CAGATGCTTT AGTTACTACA ACCATGCCCT TTCAGAGTAC GGTCTACTTG 
ATGAATTCCT GGCCTTTTGG GGATGTGCTG TGCAAGATAG TAATTTCCAT TGATTACTAC 
AACATGTTCA CCAGCATCTT CACCTTGACC ATGATGAGCG TGGACCGCTA CATTGCCGTG 
TGCCACCCCG TGAAGGCTTT GGACTTCCGC ACACCCTTGA AGGCAAAGAT CATCAATATC 
TGCATCTGGC TGCTGTCGTC ATCTGTTGGC ATCTCTGCAA TAGTCCTTGG AGGCACCAAA 
GTCAGGGAAG ACGTCGATGT CATTGAGTGC TCCTTGCAGT TCCCAGATGA TGACTACTCC 
TGGTGGGACC TCTTCATGAA GATCTGCGTC TTCATCTTTG CCTTCGTGAT CCCTGTCCTC 
ATCATCATCG TCTGCTACAC CCTGATGATC CTGCGTCTCA AGAGCGTCCG GCTCCTTTCT 
GGCTCCCGAG AGAAAGATCG CAACCTGCGT AGGATCACCA GACTGGTCCT GGTGGTGGTG 
GCAGTCTTCG TCGTCTGCTG GACTCCCATT CACATATTCA TCCTGGTGGA GGCTCTGGGG 
AGCACCTCCC ACAGCACAGC TGCTCTCTCC AGCTATTACT TCTGCATCGC CTTAGGCTAT 
ACCAACAGTA GCCTGAATCC CATTCTCTAC GCCTTTCTTG ATGAAAACTT CAAGCGGTGT 
TTCCGGGACT TCTGCTTTCC ACTGAAGATG AGGATGGAGC GGCAGAGCAC TAGCAGAGTC 
CGAAATACAG TTCAGGATCC TGCTTACCTG AGGGACATCG ATGGGATGAA TAAACCAGTA 
TGACTAGTCG TGGAGATGTC TTCGTACAGT TCTTCGGGAA GAGAGGAGTT CAATGATCTA 
GGTTTAACTC AGATCACTAC TGCAGTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

OPRK1 ( NM_001318497.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001305426.1 Homo sapiens opioid receptor kappa 1 (OPRK1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu102712
Clone ID Related Accession (Same CDS sequence)	NM_001318497.1 , NM_001318497.2
Accession Version	NM_001318497.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1230bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-25
Organism	Homo sapiens(human)
Product	kappa-type opioid receptor isoform 1x
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AY466378.1, U17298.1, BC099912.1, DA264471.1 and AK023198.1. On Jun 1, 2019 this sequence version replaced NM_001318497.1. Transcript Variant: This variant (1) represents the predominant transcript and encodes two isoforms, which result from the use of alternative in-frame translation termination codons. The shorter isoform (1) results from translation termination at the upstream UGA stop codon, while the longer isoform (1x) results from UGA stop codon readthrough to the downstream UGA termination codon. This RefSeq represents the longer, C-terminally extended isoform (1x). As the UGA stop codon has been reported to specify several alternative amino acids (tryptophan, cysteine, arginine and serine), the location of the upstream UGA stop codon in the longer isoform is denoted by an 'X'. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC099912.1, SRR1803612.57217.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145743, SAMEA2154665 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## stop codon readthrough :: PMID: 25013167 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGACTCCC CGATCCAGAT CTTCCGCGGG GAGCCGGGCC CTACCTGCGC CCCGAGCGCC 
TGCCTGCCCC CCAACAGCAG CGCCTGGTTT CCCGGCTGGG CCGAGCCCGA CAGCAACGGC 
AGCGCCGGCT CGGAGGACGC GCAGCTGGAG CCCGCGCACA TCTCCCCGGC CATCCCGGTC 
ATCATCACGG CGGTCTACTC CGTAGTGTTC GTCGTGGGCT TGGTGGGCAA CTCGCTGGTC 
ATGTTCGTGA TCATCCGATA CACAAAGATG AAGACAGCAA CCAACATTTA CATATTTAAC 
CTGGCTTTGG CAGATGCTTT AGTTACTACA ACCATGCCCT TTCAGAGTAC GGTCTACTTG 
ATGAATTCCT GGCCTTTTGG GGATGTGCTG TGCAAGATAG TAATTTCCAT TGATTACTAC 
AACATGTTCA CCAGCATCTT CACCTTGACC ATGATGAGCG TGGACCGCTA CATTGCCGTG 
TGCCACCCCG TGAAGGCTTT GGACTTCCGC ACACCCTTGA AGGCAAAGAT CATCAATATC 
TGCATCTGGC TGCTGTCGTC ATCTGTTGGC ATCTCTGCAA TAGTCCTTGG AGGCACCAAA 
GTCAGGGAAG ACGTCGATGT CATTGAGTGC TCCTTGCAGT TCCCAGATGA TGACTACTCC 
TGGTGGGACC TCTTCATGAA GATCTGCGTC TTCATCTTTG CCTTCGTGAT CCCTGTCCTC 
ATCATCATCG TCTGCTACAC CCTGATGATC CTGCGTCTCA AGAGCGTCCG GCTCCTTTCT 
GGCTCCCGAG AGAAAGATCG CAACCTGCGT AGGATCACCA GACTGGTCCT GGTGGTGGTG 
GCAGTCTTCG TCGTCTGCTG GACTCCCATT CACATATTCA TCCTGGTGGA GGCTCTGGGG 
AGCACCTCCC ACAGCACAGC TGCTCTCTCC AGCTATTACT TCTGCATCGC CTTAGGCTAT 
ACCAACAGTA GCCTGAATCC CATTCTCTAC GCCTTTCTTG ATGAAAACTT CAAGCGGTGT 
TTCCGGGACT TCTGCTTTCC ACTGAAGATG AGGATGGAGC GGCAGAGCAC TAGCAGAGTC 
CGAAATACAG TTCAGGATCC TGCTTACCTG AGGGACATCG ATGGGATGAA TAAACCAGTA 
TGACTAGTCG TGGAGATGTC TTCGTACAGT TCTTCGGGAA GAGAGGAGTT CAATGATCTA 
GGTTTAACTC AGATCACTAC TGCAGTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001305426.1
CDS	239..1468
Translation	MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV*LVVEMSSYSSSGREEFNDLGLTQITTAV

Target ORF information:

RefSeq Version	NM_001318497.2
Organism	Homo sapiens(human)
Definition	Homo sapiens opioid receptor kappa 1 (OPRK1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001318497.2

ORF Insert Sequence:

ATGGACTCCC CGATCCAGAT CTTCCGCGGG GAGCCGGGCC CTACCTGCGC CCCGAGCGCC 
TGCCTGCCCC CCAACAGCAG CGCCTGGTTT CCCGGCTGGG CCGAGCCCGA CAGCAACGGC 
AGCGCCGGCT CGGAGGACGC GCAGCTGGAG CCCGCGCACA TCTCCCCGGC CATCCCGGTC 
ATCATCACGG CGGTCTACTC CGTAGTGTTC GTCGTGGGCT TGGTGGGCAA CTCGCTGGTC 
ATGTTCGTGA TCATCCGATA CACAAAGATG AAGACAGCAA CCAACATTTA CATATTTAAC 
CTGGCTTTGG CAGATGCTTT AGTTACTACA ACCATGCCCT TTCAGAGTAC GGTCTACTTG 
ATGAATTCCT GGCCTTTTGG GGATGTGCTG TGCAAGATAG TAATTTCCAT TGATTACTAC 
AACATGTTCA CCAGCATCTT CACCTTGACC ATGATGAGCG TGGACCGCTA CATTGCCGTG 
TGCCACCCCG TGAAGGCTTT GGACTTCCGC ACACCCTTGA AGGCAAAGAT CATCAATATC 
TGCATCTGGC TGCTGTCGTC ATCTGTTGGC ATCTCTGCAA TAGTCCTTGG AGGCACCAAA 
GTCAGGGAAG ACGTCGATGT CATTGAGTGC TCCTTGCAGT TCCCAGATGA TGACTACTCC 
TGGTGGGACC TCTTCATGAA GATCTGCGTC TTCATCTTTG CCTTCGTGAT CCCTGTCCTC 
ATCATCATCG TCTGCTACAC CCTGATGATC CTGCGTCTCA AGAGCGTCCG GCTCCTTTCT 
GGCTCCCGAG AGAAAGATCG CAACCTGCGT AGGATCACCA GACTGGTCCT GGTGGTGGTG 
GCAGTCTTCG TCGTCTGCTG GACTCCCATT CACATATTCA TCCTGGTGGA GGCTCTGGGG 
AGCACCTCCC ACAGCACAGC TGCTCTCTCC AGCTATTACT TCTGCATCGC CTTAGGCTAT 
ACCAACAGTA GCCTGAATCC CATTCTCTAC GCCTTTCTTG ATGAAAACTT CAAGCGGTGT 
TTCCGGGACT TCTGCTTTCC ACTGAAGATG AGGATGGAGC GGCAGAGCAC TAGCAGAGTC 
CGAAATACAG TTCAGGATCC TGCTTACCTG AGGGACATCG ATGGGATGAA TAAACCAGTA 
TGACTAGTCG TGGAGATGTC TTCGTACAGT TCTTCGGGAA GAGAGGAGTT CAATGATCTA 
GGTTTAACTC AGATCACTAC TGCAGTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Mechanism Governing Human Kappa-Opioid Receptor Expression under Desferrioxamine-Induced Hypoxic Mimic Condition in Neuronal NMB Cells.
International journal of molecular sciences18(1)(2017 Jan)
Babcock J,Herrera A,Coricor G,Karch C,Liu AH,Rivera-Gines A,Ko JL

見積依頼

Eメール

japanmarket@genscript.com

電話

03-6811-6572

FAX

03-6811-6573
050-3174-7589(受注専用)

オンラインフォーム

オンライン注文

OPRK1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

見積依頼

Eメール

電話

FAX

オンラインフォーム

サポート

会社情報

サポート

会社情報