OPHN1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	OPHN1
Entrez Gene ID	4983
Full Name	oligophrenin 1
Synonyms	ARHGAP41,MRX60,OPN1
General protein information	Preferred Names oligophrenin 1 Names oligophrenin-1 mental retardation, X-linked 60 oligophrenin-1, Rho-GTPase activating protein
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: X Map Location: Xq12
Summary	This gene encodes a Rho-GTPase-activating protein that promotes GTP hydrolysis of Rho subfamily members. Rho proteins are important mediators of intracellular signal transduction, which affects cell migration and cell morphogenesis. Mutations in this gene are responsible for OPHN1-related X-linked cognitive disability with cerebellar hypoplasia and distinctive facial dysmorhphism. [provided by RefSeq, Jul 2008].
Disorder MIM:	300127
Disorder Html:	Mental retardation, X-linked, with cerebellar hypoplasia and distinctive facial appearance, 300486 (3)

mRNA and Protein(s)

mRNA	Protein	Name
XM_011530961.1	XP_011529263.1	oligophrenin-1 isoform X1
NM_002547.2	NP_002538.1	oligophrenin-1
XM_006724653.2	XP_006724716.1	oligophrenin-1 isoform X2
XM_017029555.1	XP_016885044.1	oligophrenin-1 isoform X4
NM_002547.3	NP_002538.1	oligophrenin-1
XM_005262270.1	XP_005262327.1	oligophrenin-1 isoform X3

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Ophn1	NP_443208.1
Rattus norvegicus (Norway rat)	Ophn1	NP_001101318.1
Pan troglodytes (chimpanzee)	OPHN1	NP_001009021.1
Xenopus tropicalis (tropical clawed frog)	ophn1	NP_001072480.1
Homo sapiens (human)	OPHN1	NP_002538.1
Canis lupus familiaris (dog)	OPHN1	XP_005641485.1
Bos taurus (cattle)	LOC525644	XP_002700095.1
Gallus gallus (chicken)	OPHN1	XP_420161.4

Gene Ontology
Bibliography

Related articles in PubMed

Large in-frame intragenic deletion of OPHN1 in a male patient with a normal intelligence quotient score.
Busa T, Caietta E, Chabrol B, Girard N, Philip N, Missirian C
Clinical dysmorphology26(1)47-49(2017 Jan)

Oligophrenin-1 regulates number, morphology and synaptic properties of adult-born inhibitory interneurons in the olfactory bulb.
Redolfi N, Galla L, Maset A, Murru L, Savoia E, Zamparo I, Gritti A, Billuart P, Passafaro M, Lodovichi C
Human molecular genetics25(23)5198-5211(2016 12)

Rho Kinase Inhibition Is Essential During In Vitro Neurogenesis and Promotes Phenotypic Rescue of Human Induced Pluripotent Stem Cell-Derived Neurons With Oligophrenin-1 Loss of Function.
Compagnucci C, Barresi S, Petrini S, Billuart P, Piccini G, Chiurazzi P, Alfieri P, Bertini E, Zanni G
Stem cells translational medicine5(7)860-9(2016 Jul)

Fasudil treatment in adult reverses behavioural changes and brain ventricular enlargement in Oligophrenin-1 mouse model of intellectual disability.
Meziane H, Khelfaoui M, Morello N, Hiba B, Calcagno E, Reibel-Foisset S, Selloum M, Chelly J, Humeau Y, Riet F, Zanni G, Herault Y, Bienvenu T, Giustetto M, Billuart P
Human molecular genetics25(11)2314-2323(2016 06)

Oligophrenin-1 is associated with cell adhesion and migration in prostate cancer.
Goto K, Oue N, Hayashi T, Shinmei S, Sakamoto N, Sentani K, Teishima J, Matsubara A, Yasui W
Pathobiology : journal of immunopathology, molecular and cellular biology81(4)190-8(2014)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

we reported on the first male patient carrying an OPHN1 mutation with IQ score within the normal limits. This observation expands the phenotypic spectrum of OPHN1 mutations.
Title: Large in-frame intragenic deletion of OPHN1 in a male patient with a normal intelligence quotient score.

Furthermore, we found that olfactory behaviour was perturbed in OPHN1 ko mice. Chronic treatment with a Rho kinase inhibitor rescued most of the defects of the newly generated neurons. Altogether, our data indicated that OPHN1 plays a key role in regulating the number, morphology and function of adult-born inhibitory interneurons and contributed to identify potential therapeutic targets.
Title: Oligophrenin-1 regulates number, morphology and synaptic properties of adult-born inhibitory interneurons in the olfactory bulb.

A neuronal stem cell-based model for the treatment of OPHN1 syndrome and other neurological disorders due to ROCK dysfunction.
Title: Rho Kinase Inhibition Is Essential During In Vitro Neurogenesis and Promotes Phenotypic Rescue of Human Induced Pluripotent Stem Cell-Derived Neurons With Oligophrenin-1 Loss of Function.

Here, we report that chronic treatment in adult mouse with Fasudil, is able to counteract vertical and horizontal hyperactivities, restores recognition memory and limits the brain ventricular dilatation observed in Ophn1(-)(/y) However, deficits in working and spatial memories are partially or not rescued by the treatment
Title: Fasudil treatment in adult reverses behavioural changes and brain ventricular enlargement in Oligophrenin-1 mouse model of intellectual disability.

results suggest that oligophrenin-1 is involved in tumor progression in prostate cancer
Title: Oligophrenin-1 is associated with cell adhesion and migration in prostate cancer.

The following OPHN1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the OPHN1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu19536	NM_002547.3 Latest version!	Homo sapiens oligophrenin 1 (OPHN1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$391.30 $559.00
OHu19536	XM_011530961.1 Latest version!	Homo sapiens oligophrenin 1 (OPHN1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$391.30 $559.00
OHu54164	XM_006724653.2 Latest version!	Homo sapiens oligophrenin 1 (OPHN1), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$391.30 $559.00
OHu54165	XM_005262270.1 Latest version!	Homo sapiens oligophrenin 1 (OPHN1), transcript variant X3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$391.30 $559.00
OHu99324	XM_017029555.1 Latest version!	Homo sapiens oligophrenin 1 (OPHN1), transcript variant X4, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$307.30 $439.00
View Old Accession Versions >>
OHu19536	NM_002547.2	Homo sapiens oligophrenin 1 (OPHN1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$391.30 $559.00
Hide Old Accession Versions >>

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***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

OPHN1 ( NM_002547.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_002538.1 Homo sapiens oligophrenin 1 (OPHN1), mRNA.

Price & Availability↑

CloneID	OHu19536
Clone ID Related Accession (Same CDS sequence)	XM_011530961.1 , NM_002547.2 , NM_002547.3
Accession Version	NM_002547.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2409bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-02
Organism	Homo sapiens(human)
Product	oligophrenin-1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BP357826.1, AJ001189.1 and AL157700.13. This sequence is a reference standard in the RefSeqGene project. On Mar 16, 2008 this sequence version replaced NM_002547.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AJ001189.1, SRR1660805.206273.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGTCATC CCCCGCTGGA GTTCAGCGAC TGCTACCTGG ACAGCCCCGA TTTCCGCGAG 
AGGCTCAAGT GTTATGAGCA GGAACTGGAG AGGACCAACA AATTCATCAA AGACGTAATC 
AAAGACGGCA ACGCGCTTAT CAGCGCTATG AGAAATTATT CTTCTGCTGT TCAGAAATTT 
TCCCAGACGC TGCAGTCATT TCAGTTTGAT TTCATTGGAG ACACTCTGAC TGATGATGAA 
ATTAACATCG CTGAATCCTT CAAGGAATTT GCTGAATTGC TCAACGAGGT AGAAAATGAG 
AGGATGATGA TGGTACACAA TGCTAGTGAT TTGCTGATTA AACCCTTGGA AAATTTCCGG 
AAGGAACAAA TAGGCTTCAC CAAGGAGCGG AAAAAGAAAT TTGAAAAGGA TGGTGAGAGG 
TTTTATTCTT TACTGGATCG GCACTTACAC CTGTCTTCAA AAAAGAAAGA ATCTCAGTTA 
CAAGAGGCAG ACCTACAGGT GGACAAGGAG AGGCACAATT TTTTCGAGTC CTCTCTTGAT 
TATGTTTATC AAATCCAGGA AGTTCAGGAG TCCAAGAAGT TCAATATTGT GGAGCCTGTC 
TTGGCCTTTC TTCATAGTCT GTTCATTTCT AACAGCCTGA CTGTGGAGCT CACACAGGAT 
TTCCTCCCAT ACAAACAACA GCTCCAACTC AGTTTACAGA ATACAAGAAA TCATTTCTCC 
AGTACCCGGG AAGAGATGGA AGAACTTAAG AAAAGGATGA AAGAAGCTCC CCAGACATGC 
AAACTTCCAG GACAGCCAAC TATTGAAGGC TATCTCTATA CACAAGAGAA ATGGGCTTTA 
GGAATATCCT GGGTGAAATA CTATTGCCAG TATGAGAAAG AGACCAAAAC ACTGACCATG 
ACGCCTATGG AGCAGAAGCC AGGTGCTAAG CAGGGGCCCT TGGACTTAAC ACTGAAGTAC 
TGTGTGAGAA GGAAGACGGA GTCTATCGAC AAGAGGTTCT GTTTTGACAT AGAAACTAAT 
GAAAGGCCAG GAACCATCAC TCTGCAGGCC CTTTCAGAAG CTAACAGAAG GCTATGGATG 
GAAGCCATGG ATGGGAAAGA ACCTATCTAC CACAGCCCTA TAACAAAACA GCAAGAAATG 
GAGCTAAATG AAGTGGGCTT CAAGTTTGTC AGGAAGTGCA TCAATATTAT TGAGACCAAA 
GGGATCAAGA CAGAAGGGTT GTACCGCACT GTGGGCAGCA ATATTCAGGT TCAGAAGCTG 
CTGAATGCCT TTTTTGATCC TAAATGCCCA GGAGATGTTG ATTTTCATAA TAGTGACTGG 
GACATTAAGA CAATCACCAG CTCCTTGAAA TTCTACCTCA GGAATCTTTC TGAACCTGTC 
ATGACCTATA GACTTCACAA AGAGCTGGTC TCTGCTGCCA AGTCTGACAA CCTGGATTAC 
CGCCTAGGAG CTATTCACTC CCTGGTATAT AAGCTACCAG AAAAGAACCG AGAGATGCTG 
GAACTTCTGA TAAGACACTT GGTCAATGTG TGTGAGCACA GCAAAGAGAA TCTTATGACC 
CCCTCCAACA TGGGAGTAAT CTTTGGGCCC ACCCTGATGA GAGCTCAGGA GGACACTGTG 
GCCGCCATGA TGAACATCAA ATTCCAGAAC ATAGTGGTGG AAATACTAAT CGAGCACTTT 
GGCAAGATCT ATTTAGGTCC ACCTGAGGAA AGCGCTGCAC CGCCAGTGCC TCCGCCTCGG 
GTGACAGCAA GAAGGCACAA ACCAATCACG ATTTCAAAGC GCTTGCTGCG AGAAAGGACG 
GTTTTCTATA CTTCTTCCCT GGATGAAAGC GAAGATGAAA TCCAACATCA AACACCGAAT 
GGTACTATCA CCAGCAGCAT AGAACCCCCC AAGCCACCAC AACACCCCAA ACTACCTATT 
CAGAGGAGTG GGGAAACTGA TCCTGGGAGG AAGTCCCCAA GCAGGCCTAT TTTGGATGGC 
AAGTTGGAGC CCTGCCCAGA GGTGGACGTG GGGAAGTTGG TGTCTAGGCT GCAGGATGGA 
GGGACCAAGA TCACCCCAAA GGCCACCAAT GGACCCATGC CAGGCTCTGG GCCCACCAAG 
ACCCCCTCTT TCCACATAAA GAGACCAGCT CCCCGGCCCC TGGCCCACCA CAAGGAGGGG 
GATGCTGACA GTTTCAGCAA AGTGCGGCCT CCAGGAGAAA AGCCAACCAT CATCCGCCCC 
CCAGTGAGGC CCCCAGATCC TCCCTGCCGG GCAGCTACTC CCCAAAAGCC AGAACCAAAG 
CCAGATATTG TGGCTGGCAA TGCGGGGGAA ATCACATCAT CTGTGGTGGC TTCCAGGACC 
AGGTTTTTTG AAACAGCTTC CCGGAAAACA GGAAGTTCTC AAGGCAGACT TCCTGGAGAT 
GAAAGTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002538.1
CDS	295..2703
Translation	MGHPPLEFSDCYLDSPDFRERLKCYEQELERTNKFIKDVIKDGNALISAMRNYSSAVQKFSQTLQSFQFDFIGDTLTDDEINIAESFKEFAELLNEVENERMMMVHNASDLLIKPLENFRKEQIGFTKERKKKFEKDGERFYSLLDRHLHLSSKKKESQLQEADLQVDKERHNFFESSLDYVYQIQEVQESKKFNIVEPVLAFLHSLFISNSLTVELTQDFLPYKQQLQLSLQNTRNHFSSTREEMEELKKRMKEAPQTCKLPGQPTIEGYLYTQEKWALGISWVKYYCQYEKETKTLTMTPMEQKPGAKQGPLDLTLKYCVRRKTESIDKRFCFDIETNERPGTITLQALSEANRRLWMEAMDGKEPIYHSPITKQQEMELNEVGFKFVRKCINIIETKGIKTEGLYRTVGSNIQVQKLLNAFFDPKCPGDVDFHNSDWDIKTITSSLKFYLRNLSEPVMTYRLHKELVSAAKSDNLDYRLGAIHSLVYKLPEKNREMLELLIRHLVNVCEHSKENLMTPSNMGVIFGPTLMRAQEDTVAAMMNIKFQNIVVEILIEHFGKIYLGPPEESAAPPVPPPRVTARRHKPITISKRLLRERTVFYTSSLDESEDEIQHQTPNGTITSSIEPPKPPQHPKLPIQRSGETDPGRKSPSRPILDGKLEPCPEVDVGKLVSRLQDGGTKITPKATNGPMPGSGPTKTPSFHIKRPAPRPLAHHKEGDADSFSKVRPPGEKPTIIRPPVRPPDPPCRAATPQKPEPKPDIVAGNAGEITSSVVASRTRFFETASRKTGSSQGRLPGDES

Target ORF information:

RefSeq Version	NM_002547.2
Organism	Homo sapiens(human)
Definition	Homo sapiens oligophrenin 1 (OPHN1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002547.2

ORF Insert Sequence:

ATGGGTCATC CCCCGCTGGA GTTCAGCGAC TGCTACCTGG ACAGCCCCGA TTTCCGCGAG 
AGGCTCAAGT GTTATGAGCA GGAACTGGAG AGGACCAACA AATTCATCAA AGACGTAATC 
AAAGACGGCA ACGCGCTTAT CAGCGCTATG AGAAATTATT CTTCTGCTGT TCAGAAATTT 
TCCCAGACGC TGCAGTCATT TCAGTTTGAT TTCATTGGAG ACACTCTGAC TGATGATGAA 
ATTAACATCG CTGAATCCTT CAAGGAATTT GCTGAATTGC TCAACGAGGT AGAAAATGAG 
AGGATGATGA TGGTACACAA TGCTAGTGAT TTGCTGATTA AACCCTTGGA AAATTTCCGG 
AAGGAACAAA TAGGCTTCAC CAAGGAGCGG AAAAAGAAAT TTGAAAAGGA TGGTGAGAGG 
TTTTATTCTT TACTGGATCG GCACTTACAC CTGTCTTCAA AAAAGAAAGA ATCTCAGTTA 
CAAGAGGCAG ACCTACAGGT GGACAAGGAG AGGCACAATT TTTTCGAGTC CTCTCTTGAT 
TATGTTTATC AAATCCAGGA AGTTCAGGAG TCCAAGAAGT TCAATATTGT GGAGCCTGTC 
TTGGCCTTTC TTCATAGTCT GTTCATTTCT AACAGCCTGA CTGTGGAGCT CACACAGGAT 
TTCCTCCCAT ACAAACAACA GCTCCAACTC AGTTTACAGA ATACAAGAAA TCATTTCTCC 
AGTACCCGGG AAGAGATGGA AGAACTTAAG AAAAGGATGA AAGAAGCTCC CCAGACATGC 
AAACTTCCAG GACAGCCAAC TATTGAAGGC TATCTCTATA CACAAGAGAA ATGGGCTTTA 
GGAATATCCT GGGTGAAATA CTATTGCCAG TATGAGAAAG AGACCAAAAC ACTGACCATG 
ACGCCTATGG AGCAGAAGCC AGGTGCTAAG CAGGGGCCCT TGGACTTAAC ACTGAAGTAC 
TGTGTGAGAA GGAAGACGGA GTCTATCGAC AAGAGGTTCT GTTTTGACAT AGAAACTAAT 
GAAAGGCCAG GAACCATCAC TCTGCAGGCC CTTTCAGAAG CTAACAGAAG GCTATGGATG 
GAAGCCATGG ATGGGAAAGA ACCTATCTAC CACAGCCCTA TAACAAAACA GCAAGAAATG 
GAGCTAAATG AAGTGGGCTT CAAGTTTGTC AGGAAGTGCA TCAATATTAT TGAGACCAAA 
GGGATCAAGA CAGAAGGGTT GTACCGCACT GTGGGCAGCA ATATTCAGGT TCAGAAGCTG 
CTGAATGCCT TTTTTGATCC TAAATGCCCA GGAGATGTTG ATTTTCATAA TAGTGACTGG 
GACATTAAGA CAATCACCAG CTCCTTGAAA TTCTACCTCA GGAATCTTTC TGAACCTGTC 
ATGACCTATA GACTTCACAA AGAGCTGGTC TCTGCTGCCA AGTCTGACAA CCTGGATTAC 
CGCCTAGGAG CTATTCACTC CCTGGTATAT AAGCTACCAG AAAAGAACCG AGAGATGCTG 
GAACTTCTGA TAAGACACTT GGTCAATGTG TGTGAGCACA GCAAAGAGAA TCTTATGACC 
CCCTCCAACA TGGGAGTAAT CTTTGGGCCC ACCCTGATGA GAGCTCAGGA GGACACTGTG 
GCCGCCATGA TGAACATCAA ATTCCAGAAC ATAGTGGTGG AAATACTAAT CGAGCACTTT 
GGCAAGATCT ATTTAGGTCC ACCTGAGGAA AGCGCTGCAC CGCCAGTGCC TCCGCCTCGG 
GTGACAGCAA GAAGGCACAA ACCAATCACG ATTTCAAAGC GCTTGCTGCG AGAAAGGACG 
GTTTTCTATA CTTCTTCCCT GGATGAAAGC GAAGATGAAA TCCAACATCA AACACCGAAT 
GGTACTATCA CCAGCAGCAT AGAACCCCCC AAGCCACCAC AACACCCCAA ACTACCTATT 
CAGAGGAGTG GGGAAACTGA TCCTGGGAGG AAGTCCCCAA GCAGGCCTAT TTTGGATGGC 
AAGTTGGAGC CCTGCCCAGA GGTGGACGTG GGGAAGTTGG TGTCTAGGCT GCAGGATGGA 
GGGACCAAGA TCACCCCAAA GGCCACCAAT GGACCCATGC CAGGCTCTGG GCCCACCAAG 
ACCCCCTCTT TCCACATAAA GAGACCAGCT CCCCGGCCCC TGGCCCACCA CAAGGAGGGG 
GATGCTGACA GTTTCAGCAA AGTGCGGCCT CCAGGAGAAA AGCCAACCAT CATCCGCCCC 
CCAGTGAGGC CCCCAGATCC TCCCTGCCGG GCAGCTACTC CCCAAAAGCC AGAACCAAAG 
CCAGATATTG TGGCTGGCAA TGCGGGGGAA ATCACATCAT CTGTGGTGGC TTCCAGGACC 
AGGTTTTTTG AAACAGCTTC CCGGAAAACA GGAAGTTCTC AAGGCAGACT TCCTGGAGAT 
GAAAGTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

OPHN1 ( NM_002547.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_002538.1 Homo sapiens oligophrenin 1 (OPHN1), mRNA.

Price & Availability↑

CloneID	OHu19536
Clone ID Related Accession (Same CDS sequence)	XM_011530961.1 , NM_002547.2 , NM_002547.3
Accession Version	NM_002547.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2409bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-16
Organism	Homo sapiens(human)
Product	oligophrenin-1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL672138.10, BP357826.1, AJ001189.1 and AL157700.13. This sequence is a reference standard in the RefSeqGene project. On Nov 24, 2018 this sequence version replaced NM_002547.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AJ001189.1, SRR1660805.206273.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000355520.6/ ENSP00000347710.5 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGGTCATC CCCCGCTGGA GTTCAGCGAC TGCTACCTGG ACAGCCCCGA TTTCCGCGAG 
AGGCTCAAGT GTTATGAGCA GGAACTGGAG AGGACCAACA AATTCATCAA AGACGTAATC 
AAAGACGGCA ACGCGCTTAT CAGCGCTATG AGAAATTATT CTTCTGCTGT TCAGAAATTT 
TCCCAGACGC TGCAGTCATT TCAGTTTGAT TTCATTGGAG ACACTCTGAC TGATGATGAA 
ATTAACATCG CTGAATCCTT CAAGGAATTT GCTGAATTGC TCAACGAGGT AGAAAATGAG 
AGGATGATGA TGGTACACAA TGCTAGTGAT TTGCTGATTA AACCCTTGGA AAATTTCCGG 
AAGGAACAAA TAGGCTTCAC CAAGGAGCGG AAAAAGAAAT TTGAAAAGGA TGGTGAGAGG 
TTTTATTCTT TACTGGATCG GCACTTACAC CTGTCTTCAA AAAAGAAAGA ATCTCAGTTA 
CAAGAGGCAG ACCTACAGGT GGACAAGGAG AGGCACAATT TTTTCGAGTC CTCTCTTGAT 
TATGTTTATC AAATCCAGGA AGTTCAGGAG TCCAAGAAGT TCAATATTGT GGAGCCTGTC 
TTGGCCTTTC TTCATAGTCT GTTCATTTCT AACAGCCTGA CTGTGGAGCT CACACAGGAT 
TTCCTCCCAT ACAAACAACA GCTCCAACTC AGTTTACAGA ATACAAGAAA TCATTTCTCC 
AGTACCCGGG AAGAGATGGA AGAACTTAAG AAAAGGATGA AAGAAGCTCC CCAGACATGC 
AAACTTCCAG GACAGCCAAC TATTGAAGGC TATCTCTATA CACAAGAGAA ATGGGCTTTA 
GGAATATCCT GGGTGAAATA CTATTGCCAG TATGAGAAAG AGACCAAAAC ACTGACCATG 
ACGCCTATGG AGCAGAAGCC AGGTGCTAAG CAGGGGCCCT TGGACTTAAC ACTGAAGTAC 
TGTGTGAGAA GGAAGACGGA GTCTATCGAC AAGAGGTTCT GTTTTGACAT AGAAACTAAT 
GAAAGGCCAG GAACCATCAC TCTGCAGGCC CTTTCAGAAG CTAACAGAAG GCTATGGATG 
GAAGCCATGG ATGGGAAAGA ACCTATCTAC CACAGCCCTA TAACAAAACA GCAAGAAATG 
GAGCTAAATG AAGTGGGCTT CAAGTTTGTC AGGAAGTGCA TCAATATTAT TGAGACCAAA 
GGGATCAAGA CAGAAGGGTT GTACCGCACT GTGGGCAGCA ATATTCAGGT TCAGAAGCTG 
CTGAATGCCT TTTTTGATCC TAAATGCCCA GGAGATGTTG ATTTTCATAA TAGTGACTGG 
GACATTAAGA CAATCACCAG CTCCTTGAAA TTCTACCTCA GGAATCTTTC TGAACCTGTC 
ATGACCTATA GACTTCACAA AGAGCTGGTC TCTGCTGCCA AGTCTGACAA CCTGGATTAC 
CGCCTAGGAG CTATTCACTC CCTGGTATAT AAGCTACCAG AAAAGAACCG AGAGATGCTG 
GAACTTCTGA TAAGACACTT GGTCAATGTG TGTGAGCACA GCAAAGAGAA TCTTATGACC 
CCCTCCAACA TGGGAGTAAT CTTTGGGCCC ACCCTGATGA GAGCTCAGGA GGACACTGTG 
GCCGCCATGA TGAACATCAA ATTCCAGAAC ATAGTGGTGG AAATACTAAT CGAGCACTTT 
GGCAAGATCT ATTTAGGTCC ACCTGAGGAA AGCGCTGCAC CGCCAGTGCC TCCGCCTCGG 
GTGACAGCAA GAAGGCACAA ACCAATCACG ATTTCAAAGC GCTTGCTGCG AGAAAGGACG 
GTTTTCTATA CTTCTTCCCT GGATGAAAGC GAAGATGAAA TCCAACATCA AACACCGAAT 
GGTACTATCA CCAGCAGCAT AGAACCCCCC AAGCCACCAC AACACCCCAA ACTACCTATT 
CAGAGGAGTG GGGAAACTGA TCCTGGGAGG AAGTCCCCAA GCAGGCCTAT TTTGGATGGC 
AAGTTGGAGC CCTGCCCAGA GGTGGACGTG GGGAAGTTGG TGTCTAGGCT GCAGGATGGA 
GGGACCAAGA TCACCCCAAA GGCCACCAAT GGACCCATGC CAGGCTCTGG GCCCACCAAG 
ACCCCCTCTT TCCACATAAA GAGACCAGCT CCCCGGCCCC TGGCCCACCA CAAGGAGGGG 
GATGCTGACA GTTTCAGCAA AGTGCGGCCT CCAGGAGAAA AGCCAACCAT CATCCGCCCC 
CCAGTGAGGC CCCCAGATCC TCCCTGCCGG GCAGCTACTC CCCAAAAGCC AGAACCAAAG 
CCAGATATTG TGGCTGGCAA TGCGGGGGAA ATCACATCAT CTGTGGTGGC TTCCAGGACC 
AGGTTTTTTG AAACAGCTTC CCGGAAAACA GGAAGTTCTC AAGGCAGACT TCCTGGAGAT 
GAAAGTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002538.1
CDS	333..2741
Translation	MGHPPLEFSDCYLDSPDFRERLKCYEQELERTNKFIKDVIKDGNALISAMRNYSSAVQKFSQTLQSFQFDFIGDTLTDDEINIAESFKEFAELLNEVENERMMMVHNASDLLIKPLENFRKEQIGFTKERKKKFEKDGERFYSLLDRHLHLSSKKKESQLQEADLQVDKERHNFFESSLDYVYQIQEVQESKKFNIVEPVLAFLHSLFISNSLTVELTQDFLPYKQQLQLSLQNTRNHFSSTREEMEELKKRMKEAPQTCKLPGQPTIEGYLYTQEKWALGISWVKYYCQYEKETKTLTMTPMEQKPGAKQGPLDLTLKYCVRRKTESIDKRFCFDIETNERPGTITLQALSEANRRLWMEAMDGKEPIYHSPITKQQEMELNEVGFKFVRKCINIIETKGIKTEGLYRTVGSNIQVQKLLNAFFDPKCPGDVDFHNSDWDIKTITSSLKFYLRNLSEPVMTYRLHKELVSAAKSDNLDYRLGAIHSLVYKLPEKNREMLELLIRHLVNVCEHSKENLMTPSNMGVIFGPTLMRAQEDTVAAMMNIKFQNIVVEILIEHFGKIYLGPPEESAAPPVPPPRVTARRHKPITISKRLLRERTVFYTSSLDESEDEIQHQTPNGTITSSIEPPKPPQHPKLPIQRSGETDPGRKSPSRPILDGKLEPCPEVDVGKLVSRLQDGGTKITPKATNGPMPGSGPTKTPSFHIKRPAPRPLAHHKEGDADSFSKVRPPGEKPTIIRPPVRPPDPPCRAATPQKPEPKPDIVAGNAGEITSSVVASRTRFFETASRKTGSSQGRLPGDES

Target ORF information:

RefSeq Version	NM_002547.3
Organism	Homo sapiens(human)
Definition	Homo sapiens oligophrenin 1 (OPHN1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002547.3

ORF Insert Sequence:

ATGGGTCATC CCCCGCTGGA GTTCAGCGAC TGCTACCTGG ACAGCCCCGA TTTCCGCGAG 
AGGCTCAAGT GTTATGAGCA GGAACTGGAG AGGACCAACA AATTCATCAA AGACGTAATC 
AAAGACGGCA ACGCGCTTAT CAGCGCTATG AGAAATTATT CTTCTGCTGT TCAGAAATTT 
TCCCAGACGC TGCAGTCATT TCAGTTTGAT TTCATTGGAG ACACTCTGAC TGATGATGAA 
ATTAACATCG CTGAATCCTT CAAGGAATTT GCTGAATTGC TCAACGAGGT AGAAAATGAG 
AGGATGATGA TGGTACACAA TGCTAGTGAT TTGCTGATTA AACCCTTGGA AAATTTCCGG 
AAGGAACAAA TAGGCTTCAC CAAGGAGCGG AAAAAGAAAT TTGAAAAGGA TGGTGAGAGG 
TTTTATTCTT TACTGGATCG GCACTTACAC CTGTCTTCAA AAAAGAAAGA ATCTCAGTTA 
CAAGAGGCAG ACCTACAGGT GGACAAGGAG AGGCACAATT TTTTCGAGTC CTCTCTTGAT 
TATGTTTATC AAATCCAGGA AGTTCAGGAG TCCAAGAAGT TCAATATTGT GGAGCCTGTC 
TTGGCCTTTC TTCATAGTCT GTTCATTTCT AACAGCCTGA CTGTGGAGCT CACACAGGAT 
TTCCTCCCAT ACAAACAACA GCTCCAACTC AGTTTACAGA ATACAAGAAA TCATTTCTCC 
AGTACCCGGG AAGAGATGGA AGAACTTAAG AAAAGGATGA AAGAAGCTCC CCAGACATGC 
AAACTTCCAG GACAGCCAAC TATTGAAGGC TATCTCTATA CACAAGAGAA ATGGGCTTTA 
GGAATATCCT GGGTGAAATA CTATTGCCAG TATGAGAAAG AGACCAAAAC ACTGACCATG 
ACGCCTATGG AGCAGAAGCC AGGTGCTAAG CAGGGGCCCT TGGACTTAAC ACTGAAGTAC 
TGTGTGAGAA GGAAGACGGA GTCTATCGAC AAGAGGTTCT GTTTTGACAT AGAAACTAAT 
GAAAGGCCAG GAACCATCAC TCTGCAGGCC CTTTCAGAAG CTAACAGAAG GCTATGGATG 
GAAGCCATGG ATGGGAAAGA ACCTATCTAC CACAGCCCTA TAACAAAACA GCAAGAAATG 
GAGCTAAATG AAGTGGGCTT CAAGTTTGTC AGGAAGTGCA TCAATATTAT TGAGACCAAA 
GGGATCAAGA CAGAAGGGTT GTACCGCACT GTGGGCAGCA ATATTCAGGT TCAGAAGCTG 
CTGAATGCCT TTTTTGATCC TAAATGCCCA GGAGATGTTG ATTTTCATAA TAGTGACTGG 
GACATTAAGA CAATCACCAG CTCCTTGAAA TTCTACCTCA GGAATCTTTC TGAACCTGTC 
ATGACCTATA GACTTCACAA AGAGCTGGTC TCTGCTGCCA AGTCTGACAA CCTGGATTAC 
CGCCTAGGAG CTATTCACTC CCTGGTATAT AAGCTACCAG AAAAGAACCG AGAGATGCTG 
GAACTTCTGA TAAGACACTT GGTCAATGTG TGTGAGCACA GCAAAGAGAA TCTTATGACC 
CCCTCCAACA TGGGAGTAAT CTTTGGGCCC ACCCTGATGA GAGCTCAGGA GGACACTGTG 
GCCGCCATGA TGAACATCAA ATTCCAGAAC ATAGTGGTGG AAATACTAAT CGAGCACTTT 
GGCAAGATCT ATTTAGGTCC ACCTGAGGAA AGCGCTGCAC CGCCAGTGCC TCCGCCTCGG 
GTGACAGCAA GAAGGCACAA ACCAATCACG ATTTCAAAGC GCTTGCTGCG AGAAAGGACG 
GTTTTCTATA CTTCTTCCCT GGATGAAAGC GAAGATGAAA TCCAACATCA AACACCGAAT 
GGTACTATCA CCAGCAGCAT AGAACCCCCC AAGCCACCAC AACACCCCAA ACTACCTATT 
CAGAGGAGTG GGGAAACTGA TCCTGGGAGG AAGTCCCCAA GCAGGCCTAT TTTGGATGGC 
AAGTTGGAGC CCTGCCCAGA GGTGGACGTG GGGAAGTTGG TGTCTAGGCT GCAGGATGGA 
GGGACCAAGA TCACCCCAAA GGCCACCAAT GGACCCATGC CAGGCTCTGG GCCCACCAAG 
ACCCCCTCTT TCCACATAAA GAGACCAGCT CCCCGGCCCC TGGCCCACCA CAAGGAGGGG 
GATGCTGACA GTTTCAGCAA AGTGCGGCCT CCAGGAGAAA AGCCAACCAT CATCCGCCCC 
CCAGTGAGGC CCCCAGATCC TCCCTGCCGG GCAGCTACTC CCCAAAAGCC AGAACCAAAG 
CCAGATATTG TGGCTGGCAA TGCGGGGGAA ATCACATCAT CTGTGGTGGC TTCCAGGACC 
AGGTTTTTTG AAACAGCTTC CCGGAAAACA GGAAGTTCTC AAGGCAGACT TCCTGGAGAT 
GAAAGTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

OPHN1 ( XM_011530961.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_011529263.1 Homo sapiens oligophrenin 1 (OPHN1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu19536
Clone ID Related Accession (Same CDS sequence)	XM_011530961.1 , NM_002547.2 , NM_002547.3
Accession Version	XM_011530961.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2409bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	oligophrenin-1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000023.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGGTCATC CCCCGCTGGA GTTCAGCGAC TGCTACCTGG ACAGCCCCGA TTTCCGCGAG 
AGGCTCAAGT GTTATGAGCA GGAACTGGAG AGGACCAACA AATTCATCAA AGACGTAATC 
AAAGACGGCA ACGCGCTTAT CAGCGCTATG AGAAATTATT CTTCTGCTGT TCAGAAATTT 
TCCCAGACGC TGCAGTCATT TCAGTTTGAT TTCATTGGAG ACACTCTGAC TGATGATGAA 
ATTAACATCG CTGAATCCTT CAAGGAATTT GCTGAATTGC TCAACGAGGT AGAAAATGAG 
AGGATGATGA TGGTACACAA TGCTAGTGAT TTGCTGATTA AACCCTTGGA AAATTTCCGG 
AAGGAACAAA TAGGCTTCAC CAAGGAGCGG AAAAAGAAAT TTGAAAAGGA TGGTGAGAGG 
TTTTATTCTT TACTGGATCG GCACTTACAC CTGTCTTCAA AAAAGAAAGA ATCTCAGTTA 
CAAGAGGCAG ACCTACAGGT GGACAAGGAG AGGCACAATT TTTTCGAGTC CTCTCTTGAT 
TATGTTTATC AAATCCAGGA AGTTCAGGAG TCCAAGAAGT TCAATATTGT GGAGCCTGTC 
TTGGCCTTTC TTCATAGTCT GTTCATTTCT AACAGCCTGA CTGTGGAGCT CACACAGGAT 
TTCCTCCCAT ACAAACAACA GCTCCAACTC AGTTTACAGA ATACAAGAAA TCATTTCTCC 
AGTACCCGGG AAGAGATGGA AGAACTTAAG AAAAGGATGA AAGAAGCTCC CCAGACATGC 
AAACTTCCAG GACAGCCAAC TATTGAAGGC TATCTCTATA CACAAGAGAA ATGGGCTTTA 
GGAATATCCT GGGTGAAATA CTATTGCCAG TATGAGAAAG AGACCAAAAC ACTGACCATG 
ACGCCTATGG AGCAGAAGCC AGGTGCTAAG CAGGGGCCCT TGGACTTAAC ACTGAAGTAC 
TGTGTGAGAA GGAAGACGGA GTCTATCGAC AAGAGGTTCT GTTTTGACAT AGAAACTAAT 
GAAAGGCCAG GAACCATCAC TCTGCAGGCC CTTTCAGAAG CTAACAGAAG GCTATGGATG 
GAAGCCATGG ATGGGAAAGA ACCTATCTAC CACAGCCCTA TAACAAAACA GCAAGAAATG 
GAGCTAAATG AAGTGGGCTT CAAGTTTGTC AGGAAGTGCA TCAATATTAT TGAGACCAAA 
GGGATCAAGA CAGAAGGGTT GTACCGCACT GTGGGCAGCA ATATTCAGGT TCAGAAGCTG 
CTGAATGCCT TTTTTGATCC TAAATGCCCA GGAGATGTTG ATTTTCATAA TAGTGACTGG 
GACATTAAGA CAATCACCAG CTCCTTGAAA TTCTACCTCA GGAATCTTTC TGAACCTGTC 
ATGACCTATA GACTTCACAA AGAGCTGGTC TCTGCTGCCA AGTCTGACAA CCTGGATTAC 
CGCCTAGGAG CTATTCACTC CCTGGTATAT AAGCTACCAG AAAAGAACCG AGAGATGCTG 
GAACTTCTGA TAAGACACTT GGTCAATGTG TGTGAGCACA GCAAAGAGAA TCTTATGACC 
CCCTCCAACA TGGGAGTAAT CTTTGGGCCC ACCCTGATGA GAGCTCAGGA GGACACTGTG 
GCCGCCATGA TGAACATCAA ATTCCAGAAC ATAGTGGTGG AAATACTAAT CGAGCACTTT 
GGCAAGATCT ATTTAGGTCC ACCTGAGGAA AGCGCTGCAC CGCCAGTGCC TCCGCCTCGG 
GTGACAGCAA GAAGGCACAA ACCAATCACG ATTTCAAAGC GCTTGCTGCG AGAAAGGACG 
GTTTTCTATA CTTCTTCCCT GGATGAAAGC GAAGATGAAA TCCAACATCA AACACCGAAT 
GGTACTATCA CCAGCAGCAT AGAACCCCCC AAGCCACCAC AACACCCCAA ACTACCTATT 
CAGAGGAGTG GGGAAACTGA TCCTGGGAGG AAGTCCCCAA GCAGGCCTAT TTTGGATGGC 
AAGTTGGAGC CCTGCCCAGA GGTGGACGTG GGGAAGTTGG TGTCTAGGCT GCAGGATGGA 
GGGACCAAGA TCACCCCAAA GGCCACCAAT GGACCCATGC CAGGCTCTGG GCCCACCAAG 
ACCCCCTCTT TCCACATAAA GAGACCAGCT CCCCGGCCCC TGGCCCACCA CAAGGAGGGG 
GATGCTGACA GTTTCAGCAA AGTGCGGCCT CCAGGAGAAA AGCCAACCAT CATCCGCCCC 
CCAGTGAGGC CCCCAGATCC TCCCTGCCGG GCAGCTACTC CCCAAAAGCC AGAACCAAAG 
CCAGATATTG TGGCTGGCAA TGCGGGGGAA ATCACATCAT CTGTGGTGGC TTCCAGGACC 
AGGTTTTTTG AAACAGCTTC CCGGAAAACA GGAAGTTCTC AAGGCAGACT TCCTGGAGAT 
GAAAGTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011529263.1
CDS	216..2624
Translation	MGHPPLEFSDCYLDSPDFRERLKCYEQELERTNKFIKDVIKDGNALISAMRNYSSAVQKFSQTLQSFQFDFIGDTLTDDEINIAESFKEFAELLNEVENERMMMVHNASDLLIKPLENFRKEQIGFTKERKKKFEKDGERFYSLLDRHLHLSSKKKESQLQEADLQVDKERHNFFESSLDYVYQIQEVQESKKFNIVEPVLAFLHSLFISNSLTVELTQDFLPYKQQLQLSLQNTRNHFSSTREEMEELKKRMKEAPQTCKLPGQPTIEGYLYTQEKWALGISWVKYYCQYEKETKTLTMTPMEQKPGAKQGPLDLTLKYCVRRKTESIDKRFCFDIETNERPGTITLQALSEANRRLWMEAMDGKEPIYHSPITKQQEMELNEVGFKFVRKCINIIETKGIKTEGLYRTVGSNIQVQKLLNAFFDPKCPGDVDFHNSDWDIKTITSSLKFYLRNLSEPVMTYRLHKELVSAAKSDNLDYRLGAIHSLVYKLPEKNREMLELLIRHLVNVCEHSKENLMTPSNMGVIFGPTLMRAQEDTVAAMMNIKFQNIVVEILIEHFGKIYLGPPEESAAPPVPPPRVTARRHKPITISKRLLRERTVFYTSSLDESEDEIQHQTPNGTITSSIEPPKPPQHPKLPIQRSGETDPGRKSPSRPILDGKLEPCPEVDVGKLVSRLQDGGTKITPKATNGPMPGSGPTKTPSFHIKRPAPRPLAHHKEGDADSFSKVRPPGEKPTIIRPPVRPPDPPCRAATPQKPEPKPDIVAGNAGEITSSVVASRTRFFETASRKTGSSQGRLPGDES

Target ORF information:

RefSeq Version	XM_011530961.1
Organism	Homo sapiens(human)
Definition	Homo sapiens oligophrenin 1 (OPHN1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011530961.1

ORF Insert Sequence:

ATGGGTCATC CCCCGCTGGA GTTCAGCGAC TGCTACCTGG ACAGCCCCGA TTTCCGCGAG 
AGGCTCAAGT GTTATGAGCA GGAACTGGAG AGGACCAACA AATTCATCAA AGACGTAATC 
AAAGACGGCA ACGCGCTTAT CAGCGCTATG AGAAATTATT CTTCTGCTGT TCAGAAATTT 
TCCCAGACGC TGCAGTCATT TCAGTTTGAT TTCATTGGAG ACACTCTGAC TGATGATGAA 
ATTAACATCG CTGAATCCTT CAAGGAATTT GCTGAATTGC TCAACGAGGT AGAAAATGAG 
AGGATGATGA TGGTACACAA TGCTAGTGAT TTGCTGATTA AACCCTTGGA AAATTTCCGG 
AAGGAACAAA TAGGCTTCAC CAAGGAGCGG AAAAAGAAAT TTGAAAAGGA TGGTGAGAGG 
TTTTATTCTT TACTGGATCG GCACTTACAC CTGTCTTCAA AAAAGAAAGA ATCTCAGTTA 
CAAGAGGCAG ACCTACAGGT GGACAAGGAG AGGCACAATT TTTTCGAGTC CTCTCTTGAT 
TATGTTTATC AAATCCAGGA AGTTCAGGAG TCCAAGAAGT TCAATATTGT GGAGCCTGTC 
TTGGCCTTTC TTCATAGTCT GTTCATTTCT AACAGCCTGA CTGTGGAGCT CACACAGGAT 
TTCCTCCCAT ACAAACAACA GCTCCAACTC AGTTTACAGA ATACAAGAAA TCATTTCTCC 
AGTACCCGGG AAGAGATGGA AGAACTTAAG AAAAGGATGA AAGAAGCTCC CCAGACATGC 
AAACTTCCAG GACAGCCAAC TATTGAAGGC TATCTCTATA CACAAGAGAA ATGGGCTTTA 
GGAATATCCT GGGTGAAATA CTATTGCCAG TATGAGAAAG AGACCAAAAC ACTGACCATG 
ACGCCTATGG AGCAGAAGCC AGGTGCTAAG CAGGGGCCCT TGGACTTAAC ACTGAAGTAC 
TGTGTGAGAA GGAAGACGGA GTCTATCGAC AAGAGGTTCT GTTTTGACAT AGAAACTAAT 
GAAAGGCCAG GAACCATCAC TCTGCAGGCC CTTTCAGAAG CTAACAGAAG GCTATGGATG 
GAAGCCATGG ATGGGAAAGA ACCTATCTAC CACAGCCCTA TAACAAAACA GCAAGAAATG 
GAGCTAAATG AAGTGGGCTT CAAGTTTGTC AGGAAGTGCA TCAATATTAT TGAGACCAAA 
GGGATCAAGA CAGAAGGGTT GTACCGCACT GTGGGCAGCA ATATTCAGGT TCAGAAGCTG 
CTGAATGCCT TTTTTGATCC TAAATGCCCA GGAGATGTTG ATTTTCATAA TAGTGACTGG 
GACATTAAGA CAATCACCAG CTCCTTGAAA TTCTACCTCA GGAATCTTTC TGAACCTGTC 
ATGACCTATA GACTTCACAA AGAGCTGGTC TCTGCTGCCA AGTCTGACAA CCTGGATTAC 
CGCCTAGGAG CTATTCACTC CCTGGTATAT AAGCTACCAG AAAAGAACCG AGAGATGCTG 
GAACTTCTGA TAAGACACTT GGTCAATGTG TGTGAGCACA GCAAAGAGAA TCTTATGACC 
CCCTCCAACA TGGGAGTAAT CTTTGGGCCC ACCCTGATGA GAGCTCAGGA GGACACTGTG 
GCCGCCATGA TGAACATCAA ATTCCAGAAC ATAGTGGTGG AAATACTAAT CGAGCACTTT 
GGCAAGATCT ATTTAGGTCC ACCTGAGGAA AGCGCTGCAC CGCCAGTGCC TCCGCCTCGG 
GTGACAGCAA GAAGGCACAA ACCAATCACG ATTTCAAAGC GCTTGCTGCG AGAAAGGACG 
GTTTTCTATA CTTCTTCCCT GGATGAAAGC GAAGATGAAA TCCAACATCA AACACCGAAT 
GGTACTATCA CCAGCAGCAT AGAACCCCCC AAGCCACCAC AACACCCCAA ACTACCTATT 
CAGAGGAGTG GGGAAACTGA TCCTGGGAGG AAGTCCCCAA GCAGGCCTAT TTTGGATGGC 
AAGTTGGAGC CCTGCCCAGA GGTGGACGTG GGGAAGTTGG TGTCTAGGCT GCAGGATGGA 
GGGACCAAGA TCACCCCAAA GGCCACCAAT GGACCCATGC CAGGCTCTGG GCCCACCAAG 
ACCCCCTCTT TCCACATAAA GAGACCAGCT CCCCGGCCCC TGGCCCACCA CAAGGAGGGG 
GATGCTGACA GTTTCAGCAA AGTGCGGCCT CCAGGAGAAA AGCCAACCAT CATCCGCCCC 
CCAGTGAGGC CCCCAGATCC TCCCTGCCGG GCAGCTACTC CCCAAAAGCC AGAACCAAAG 
CCAGATATTG TGGCTGGCAA TGCGGGGGAA ATCACATCAT CTGTGGTGGC TTCCAGGACC 
AGGTTTTTTG AAACAGCTTC CCGGAAAACA GGAAGTTCTC AAGGCAGACT TCCTGGAGAT 
GAAAGTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

OPHN1 ( XM_006724653.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_006724716.1 Homo sapiens oligophrenin 1 (OPHN1), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OHu54164
Clone ID Related Accession (Same CDS sequence)	XM_006724653.2
Accession Version	XM_006724653.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2382bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	oligophrenin-1 isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000023.11) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_006724653.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGGTCATC CCCCGCTGGA GTTCAGCGAC TGCTACCTGG ACAGCCCCGA TTTCCGCGAG 
AGGCTCAAGT GTTATGAGCA GGAACTGGAG AGGACCAACA AATTCATCAA AGACGTAATC 
AAAGACGGCA ACGCGCTTAT CAGCGCTATG AGAAATTATT CTTCTGCTGT TCAGAAATTT 
TCCCAGACGC TGCAGTCATT TCAGTTTGAT TTCATTGGAG ACACTCTGAC TGATGATGAA 
ATTAACATCG CTGAATCCTT CAAGGAATTT GCTGAATTGC TCAACGAGGT AGAAAATGAG 
AGGATGATGA TGGTACACAA TGCTAGTGAT TTGCTGATTA AACCCTTGGA AAATTTCCGG 
AAGGAACAAA TAGGCTTCAC CAAGGAGCGG AAAAAGAAAT TTGAAAAGGA TGGTGAGAGG 
TTTTATTCTT TACTGGATCG GCACTTACAC CTGTCTTCAA AAAAGAAAGA ATCTCAGTTA 
CAAGAGGCAG ACCTACAGGT GGACAAGGAG AGGCACAATT TTTTCGAGTC CTCTCTTGAT 
TATGTTTATC AAATCCAGGA AGTTCAGGAG TCCAAGAAGT TCAATATTGT GGAGCCTGTC 
TTGGCCTTTC TTCATAGTCT GTTCATTTCT AACAGCCTGA CTGTGGAGCT CACACAGGAT 
TTCCTCCCAT ACAAACAACA GCTCCAACTC AGTTTACAGA ATACAAGAAA TCATTTCTCC 
AGTACCCGGG AAGAGATGGA AGAACTTAAG AAAAGGATGA AAGAAGCTCC CCAGACATGC 
AAACTTCCAG GACAGCCAAC TATTGAAGGC TATCTCTATA CACAAGAGAA ATGGGCTTTA 
GGAATATCCT GGGTGAAATA CTATTGCCAG TATGAGAAAG AGACCAAAAC ACTGACCATG 
ACGCCTATGG AGCAGAAGCC AGGTGCTAAG CAGGGGCCCT TGGACTTAAC ACTGAAGTAC 
TGTGTGAGAA GGAAGACGGA GTCTATCGAC AAGAGGTTCT GTTTTGACAT AGAAACTAAT 
GAAAGGCCAG GAACCATCAC TCTGCAGGCC CTTTCAGAAG CTAACAGAAG GCTATGGATG 
GAAGCCATGG ATGGGAAAGA ACCTATCTAC CACAGCCCTA TAACAAAACA GCAAGAAATG 
GAGCTAAATG AAGTGGGCTT CAAGTTTGTC AGGAAGTGCA TCAATATTAT TGAGACCAAA 
GGGATCAAGA CAGAAGGGTT GTACCGCACT GTGGGCAGCA ATATTCAGGT TCAGAAGCTG 
CTGAATGCCT TTTTTGATCC TAAATGCCCA GGAGATGTTG ATTTTCATAA TAGTGACTGG 
GACATTAAGA CAATCACCAG CTCCTTGAAA TTCTACCTCA GGAATCTTTC TGAACCTGTC 
ATGACCTATA GACTTCACAA AGAGCTGGTC TCTGCTGCCA AGTCTGACAA CCTGGATTAC 
CGCCTAGGAG CTATTCACTC CCTGGTATAT AAGCTACCAG AAAAGAACCG AGAGATGCTG 
GAACTTCTGA TAAGACACTT GGTCAATGTG TGTGAGCACA GCAAAGAGAA TCTTATGACC 
CCCTCCAACA TGGGAGTAAT CTTTGGGCCC ACCCTGATGA GAGCTCAGGA GGACACTGTG 
GCCGCCATGA TGAACATCAA ATTCCAGAAC ATAGTGGTGG AAATACTAAT CGAGCACTTT 
GGCAAGATCT ATTTAGGTCC ACCTGAGGAA AGCGCTGCAC CGCCAGTGCC TCCGCCTCGG 
GTGACAGCAA GAAGGCACAA ACCAATCACG ATTTCAAAGC GCTTGCTGCG AGAAAGGACG 
GTTTTCTATA CTTCTTCCCT GGATGAAAGC GAAGATGAAA TCCAACATCA AACACCGAAT 
GGTACTATCA CCAGCAGCAT AGAACCCCCC AAGCCACCAC AACACCCCAA ACTACCTATT 
CAGAGGAGTG GGGAAACTGA TCCTGGGAGG AAGTCCCCAA GCAGGCCTAT TTTGGATGGC 
AAGTTGGAGC CCTGCCCAGA GGTGGACGTG GGGAAGTTGG TGTCTAGGCT GCAGGATGGA 
GGGACCAAGA TCACCCCAAA GGCCACCAAT GGACCCATGC CAGGCTCTGG GCCCACCAAG 
ACCCCCTCTT TCCACATAAA GAGACCAGCT CCCCGGCCCC TGGCCCACCA CAAGGAGGGG 
GATGCTGACA GTTTCAGCAA AGTGCGGCCT CCAGGAGAAA AGCCAACCAT CATCCGCCCC 
CCAGTGAGGC CCCCAGATCC TCCCTGCCGG GCAGCTACTC CCCAAAAGCC AGAACCAAAG 
CCAGATATTG TGGCTGGCAA TGCGGGGGAA ATCACATCAT CTGTGGTGGC TTCCAGGACC 
AGGTTTTTTG AAACAGCTTC CCGGAAAACA GGAAGGTTTT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006724716.1
CDS	365..2746
Translation	MGHPPLEFSDCYLDSPDFRERLKCYEQELERTNKFIKDVIKDGNALISAMRNYSSAVQKFSQTLQSFQFDFIGDTLTDDEINIAESFKEFAELLNEVENERMMMVHNASDLLIKPLENFRKEQIGFTKERKKKFEKDGERFYSLLDRHLHLSSKKKESQLQEADLQVDKERHNFFESSLDYVYQIQEVQESKKFNIVEPVLAFLHSLFISNSLTVELTQDFLPYKQQLQLSLQNTRNHFSSTREEMEELKKRMKEAPQTCKLPGQPTIEGYLYTQEKWALGISWVKYYCQYEKETKTLTMTPMEQKPGAKQGPLDLTLKYCVRRKTESIDKRFCFDIETNERPGTITLQALSEANRRLWMEAMDGKEPIYHSPITKQQEMELNEVGFKFVRKCINIIETKGIKTEGLYRTVGSNIQVQKLLNAFFDPKCPGDVDFHNSDWDIKTITSSLKFYLRNLSEPVMTYRLHKELVSAAKSDNLDYRLGAIHSLVYKLPEKNREMLELLIRHLVNVCEHSKENLMTPSNMGVIFGPTLMRAQEDTVAAMMNIKFQNIVVEILIEHFGKIYLGPPEESAAPPVPPPRVTARRHKPITISKRLLRERTVFYTSSLDESEDEIQHQTPNGTITSSIEPPKPPQHPKLPIQRSGETDPGRKSPSRPILDGKLEPCPEVDVGKLVSRLQDGGTKITPKATNGPMPGSGPTKTPSFHIKRPAPRPLAHHKEGDADSFSKVRPPGEKPTIIRPPVRPPDPPCRAATPQKPEPKPDIVAGNAGEITSSVVASRTRFFETASRKTGRF

Target ORF information:

RefSeq Version	XM_006724653.2
Organism	Homo sapiens(human)
Definition	Homo sapiens oligophrenin 1 (OPHN1), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006724653.2

ORF Insert Sequence:

ATGGGTCATC CCCCGCTGGA GTTCAGCGAC TGCTACCTGG ACAGCCCCGA TTTCCGCGAG 
AGGCTCAAGT GTTATGAGCA GGAACTGGAG AGGACCAACA AATTCATCAA AGACGTAATC 
AAAGACGGCA ACGCGCTTAT CAGCGCTATG AGAAATTATT CTTCTGCTGT TCAGAAATTT 
TCCCAGACGC TGCAGTCATT TCAGTTTGAT TTCATTGGAG ACACTCTGAC TGATGATGAA 
ATTAACATCG CTGAATCCTT CAAGGAATTT GCTGAATTGC TCAACGAGGT AGAAAATGAG 
AGGATGATGA TGGTACACAA TGCTAGTGAT TTGCTGATTA AACCCTTGGA AAATTTCCGG 
AAGGAACAAA TAGGCTTCAC CAAGGAGCGG AAAAAGAAAT TTGAAAAGGA TGGTGAGAGG 
TTTTATTCTT TACTGGATCG GCACTTACAC CTGTCTTCAA AAAAGAAAGA ATCTCAGTTA 
CAAGAGGCAG ACCTACAGGT GGACAAGGAG AGGCACAATT TTTTCGAGTC CTCTCTTGAT 
TATGTTTATC AAATCCAGGA AGTTCAGGAG TCCAAGAAGT TCAATATTGT GGAGCCTGTC 
TTGGCCTTTC TTCATAGTCT GTTCATTTCT AACAGCCTGA CTGTGGAGCT CACACAGGAT 
TTCCTCCCAT ACAAACAACA GCTCCAACTC AGTTTACAGA ATACAAGAAA TCATTTCTCC 
AGTACCCGGG AAGAGATGGA AGAACTTAAG AAAAGGATGA AAGAAGCTCC CCAGACATGC 
AAACTTCCAG GACAGCCAAC TATTGAAGGC TATCTCTATA CACAAGAGAA ATGGGCTTTA 
GGAATATCCT GGGTGAAATA CTATTGCCAG TATGAGAAAG AGACCAAAAC ACTGACCATG 
ACGCCTATGG AGCAGAAGCC AGGTGCTAAG CAGGGGCCCT TGGACTTAAC ACTGAAGTAC 
TGTGTGAGAA GGAAGACGGA GTCTATCGAC AAGAGGTTCT GTTTTGACAT AGAAACTAAT 
GAAAGGCCAG GAACCATCAC TCTGCAGGCC CTTTCAGAAG CTAACAGAAG GCTATGGATG 
GAAGCCATGG ATGGGAAAGA ACCTATCTAC CACAGCCCTA TAACAAAACA GCAAGAAATG 
GAGCTAAATG AAGTGGGCTT CAAGTTTGTC AGGAAGTGCA TCAATATTAT TGAGACCAAA 
GGGATCAAGA CAGAAGGGTT GTACCGCACT GTGGGCAGCA ATATTCAGGT TCAGAAGCTG 
CTGAATGCCT TTTTTGATCC TAAATGCCCA GGAGATGTTG ATTTTCATAA TAGTGACTGG 
GACATTAAGA CAATCACCAG CTCCTTGAAA TTCTACCTCA GGAATCTTTC TGAACCTGTC 
ATGACCTATA GACTTCACAA AGAGCTGGTC TCTGCTGCCA AGTCTGACAA CCTGGATTAC 
CGCCTAGGAG CTATTCACTC CCTGGTATAT AAGCTACCAG AAAAGAACCG AGAGATGCTG 
GAACTTCTGA TAAGACACTT GGTCAATGTG TGTGAGCACA GCAAAGAGAA TCTTATGACC 
CCCTCCAACA TGGGAGTAAT CTTTGGGCCC ACCCTGATGA GAGCTCAGGA GGACACTGTG 
GCCGCCATGA TGAACATCAA ATTCCAGAAC ATAGTGGTGG AAATACTAAT CGAGCACTTT 
GGCAAGATCT ATTTAGGTCC ACCTGAGGAA AGCGCTGCAC CGCCAGTGCC TCCGCCTCGG 
GTGACAGCAA GAAGGCACAA ACCAATCACG ATTTCAAAGC GCTTGCTGCG AGAAAGGACG 
GTTTTCTATA CTTCTTCCCT GGATGAAAGC GAAGATGAAA TCCAACATCA AACACCGAAT 
GGTACTATCA CCAGCAGCAT AGAACCCCCC AAGCCACCAC AACACCCCAA ACTACCTATT 
CAGAGGAGTG GGGAAACTGA TCCTGGGAGG AAGTCCCCAA GCAGGCCTAT TTTGGATGGC 
AAGTTGGAGC CCTGCCCAGA GGTGGACGTG GGGAAGTTGG TGTCTAGGCT GCAGGATGGA 
GGGACCAAGA TCACCCCAAA GGCCACCAAT GGACCCATGC CAGGCTCTGG GCCCACCAAG 
ACCCCCTCTT TCCACATAAA GAGACCAGCT CCCCGGCCCC TGGCCCACCA CAAGGAGGGG 
GATGCTGACA GTTTCAGCAA AGTGCGGCCT CCAGGAGAAA AGCCAACCAT CATCCGCCCC 
CCAGTGAGGC CCCCAGATCC TCCCTGCCGG GCAGCTACTC CCCAAAAGCC AGAACCAAAG 
CCAGATATTG TGGCTGGCAA TGCGGGGGAA ATCACATCAT CTGTGGTGGC TTCCAGGACC 
AGGTTTTTTG AAACAGCTTC CCGGAAAACA GGAAGGTTTT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

OPHN1 ( XM_005262270.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_005262327.1 Homo sapiens oligophrenin 1 (OPHN1), transcript variant X3, mRNA.

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CloneID	OHu54165
Clone ID Related Accession (Same CDS sequence)	XM_005262270.1
Accession Version	XM_005262270.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2085bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	oligophrenin-1 isoform X3
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000023.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGGTCATC CCCCGCTGGA GTTCAGCGAC TGCTACCTGG ACAGCCCCGA TTTCCGCGAG 
AGGCTCAAGT GTTATGAGCA GGAACTGGAG AGGACCAACA AATTCATCAA AGACGTAATC 
AAAGACGGCA ACGCGCTTAT CAGCGCTATG AGAAATTATT CTTCTGCTGT TCAGAAATTT 
TCCCAGACGC TGCAGTCATT TCAGTTTGAT TTCATTGGAG ACACTCTGAC TGATGATGAA 
ATTAACATCG CTGAATCCTT CAAGGAATTT GCTGAATTGC TCAACGAGGT AGAAAATGAG 
AGGATGATGA TGGTACACAA TGCTAGTGAT TTGCTGATTA AACCCTTGGA AAATTTCCGG 
AAGGAACAAA TAGGCTTCAC CAAGGAGCGG AAAAAGAAAT TTGAAAAGGA TGGTGAGAGG 
TTTTATTCTT TACTGGATCG GCACTTACAC CTGTCTTCAA AAAAGAAAGA ATCTCAGTTA 
CAAGAGGCAG ACCTACAGGT GGACAAGGAG AGGCACAATT TTTTCGAGTC CTCTCTTGAT 
TATGTTTATC AAATCCAGGA AGTTCAGGAG TCCAAGAAGT TCAATATTGT GGAGCCTGTC 
TTGGCCTTTC TTCATAGTCT GTTCATTTCT AACAGCCTGA CTGTGGAGCT CACACAGGAT 
TTCCTCCCAT ACAAACAACA GCTCCAACTC AGTTTACAGA ATACAAGAAA TCATTTCTCC 
AGTACCCGGG AAGAGATGGA AGAACTTAAG AAAAGGATGA AAGAAGCTCC CCAGACATGC 
AAACTTCCAG GACAGCCAAC TATTGAAGGC TATCTCTATA CACAAGAGAA ATGGGCTTTA 
GGAATATCCT GGGTGAAATA CTATTGCCAG TATGAGAAAG AGACCAAAAC ACTGACCATG 
ACGCCTATGG AGCAGAAGCC AGGTGCTAAG CAGGGGCCCT TGGACTTAAC ACTGAAGTAC 
TGTGTGAGAA GGAAGACGGA GTCTATCGAC AAGAGGTTCT GTTTTGACAT AGAAACTAAT 
GAAAGGCCAG GAACCATCAC TCTGCAGGCC CTTTCAGAAG CTAACAGAAG GCTATGGATG 
GAAGCCATGG ATGGGAAAGA ACCTATCTAC CACAGCCCTA TAACAAAACA GCAAGAAATG 
GAGCTAAATG AAGTGGGCTT CAAGTTTGTC AGGAAGTGCA TCAATATTAT TGAGACCAAA 
GGGATCAAGA CAGAAGGGTT GTACCGCACT GTGGGCAGCA ATATTCAGGT TCAGAAGCTG 
CTGAATGCCT TTTTTGATCC TAAATGCCCA GGAGATGTTG ATTTTCATAA TAGTGACTGG 
GACATTAAGA CAATCACCAG CTCCTTGAAA TTCTACCTCA GGAATCTTTC TGAACCTGTC 
ATGACCTATA GACTTCACAA AGAGCTGGTC TCTGCTGCCA AGTCTGACAA CCTGGATTAC 
CGCCTAGGAG CTATTCACTC CCTGGTATAT AAGCTACCAG AAAAGAACCG AGAGATGCTG 
GAACTTCTGA TAAGACACTT GGTCAATGTG TGTGAGCACA GCAAAGAGAA TCTTATGACC 
CCCTCCAACA TGGGAGTAAT CTTTGGGCCC ACCCTGATGA GAGCTCAGGA GGACACTGTG 
GCCGCCATGA TGAACATCAA ATTCCAGAAC ATAGTGGTGG AAATACTAAT CGAGCACTTT 
GGCAAGATCT ATTTAGGTCC ACCTGAGGAA AGCGCTGCAC CGCCAGTGCC TCCGCCTCGG 
GTGACAGCAA GAAGGCACAA ACCAATCACG ATTTCAAAGC GCTTGCTGCG AGAAAGGACG 
GTTTTCTATA CTTCTTCCCT GGATGAAAGC GAAGGGGATG CTGACAGTTT CAGCAAAGTG 
CGGCCTCCAG GAGAAAAGCC AACCATCATC CGCCCCCCAG TGAGGCCCCC AGATCCTCCC 
TGCCGGGCAG CTACTCCCCA AAAGCCAGAA CCAAAGCCAG ATATTGTGGC TGGCAATGCG 
GGGGAAATCA CATCATCTGT GGTGGCTTCC AGGACCAGGT TTTTTGAAAC AGCTTCCCGG 
AAAACAGGAA GTTCTCAAGG CAGACTTCCT GGAGATGAAA GTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_005262327.1
CDS	365..2449
Translation	MGHPPLEFSDCYLDSPDFRERLKCYEQELERTNKFIKDVIKDGNALISAMRNYSSAVQKFSQTLQSFQFDFIGDTLTDDEINIAESFKEFAELLNEVENERMMMVHNASDLLIKPLENFRKEQIGFTKERKKKFEKDGERFYSLLDRHLHLSSKKKESQLQEADLQVDKERHNFFESSLDYVYQIQEVQESKKFNIVEPVLAFLHSLFISNSLTVELTQDFLPYKQQLQLSLQNTRNHFSSTREEMEELKKRMKEAPQTCKLPGQPTIEGYLYTQEKWALGISWVKYYCQYEKETKTLTMTPMEQKPGAKQGPLDLTLKYCVRRKTESIDKRFCFDIETNERPGTITLQALSEANRRLWMEAMDGKEPIYHSPITKQQEMELNEVGFKFVRKCINIIETKGIKTEGLYRTVGSNIQVQKLLNAFFDPKCPGDVDFHNSDWDIKTITSSLKFYLRNLSEPVMTYRLHKELVSAAKSDNLDYRLGAIHSLVYKLPEKNREMLELLIRHLVNVCEHSKENLMTPSNMGVIFGPTLMRAQEDTVAAMMNIKFQNIVVEILIEHFGKIYLGPPEESAAPPVPPPRVTARRHKPITISKRLLRERTVFYTSSLDESEGDADSFSKVRPPGEKPTIIRPPVRPPDPPCRAATPQKPEPKPDIVAGNAGEITSSVVASRTRFFETASRKTGSSQGRLPGDES

Target ORF information:

RefSeq Version	XM_005262270.1
Organism	Homo sapiens(human)
Definition	Homo sapiens oligophrenin 1 (OPHN1), transcript variant X3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005262270.1

ORF Insert Sequence:

ATGGGTCATC CCCCGCTGGA GTTCAGCGAC TGCTACCTGG ACAGCCCCGA TTTCCGCGAG 
AGGCTCAAGT GTTATGAGCA GGAACTGGAG AGGACCAACA AATTCATCAA AGACGTAATC 
AAAGACGGCA ACGCGCTTAT CAGCGCTATG AGAAATTATT CTTCTGCTGT TCAGAAATTT 
TCCCAGACGC TGCAGTCATT TCAGTTTGAT TTCATTGGAG ACACTCTGAC TGATGATGAA 
ATTAACATCG CTGAATCCTT CAAGGAATTT GCTGAATTGC TCAACGAGGT AGAAAATGAG 
AGGATGATGA TGGTACACAA TGCTAGTGAT TTGCTGATTA AACCCTTGGA AAATTTCCGG 
AAGGAACAAA TAGGCTTCAC CAAGGAGCGG AAAAAGAAAT TTGAAAAGGA TGGTGAGAGG 
TTTTATTCTT TACTGGATCG GCACTTACAC CTGTCTTCAA AAAAGAAAGA ATCTCAGTTA 
CAAGAGGCAG ACCTACAGGT GGACAAGGAG AGGCACAATT TTTTCGAGTC CTCTCTTGAT 
TATGTTTATC AAATCCAGGA AGTTCAGGAG TCCAAGAAGT TCAATATTGT GGAGCCTGTC 
TTGGCCTTTC TTCATAGTCT GTTCATTTCT AACAGCCTGA CTGTGGAGCT CACACAGGAT 
TTCCTCCCAT ACAAACAACA GCTCCAACTC AGTTTACAGA ATACAAGAAA TCATTTCTCC 
AGTACCCGGG AAGAGATGGA AGAACTTAAG AAAAGGATGA AAGAAGCTCC CCAGACATGC 
AAACTTCCAG GACAGCCAAC TATTGAAGGC TATCTCTATA CACAAGAGAA ATGGGCTTTA 
GGAATATCCT GGGTGAAATA CTATTGCCAG TATGAGAAAG AGACCAAAAC ACTGACCATG 
ACGCCTATGG AGCAGAAGCC AGGTGCTAAG CAGGGGCCCT TGGACTTAAC ACTGAAGTAC 
TGTGTGAGAA GGAAGACGGA GTCTATCGAC AAGAGGTTCT GTTTTGACAT AGAAACTAAT 
GAAAGGCCAG GAACCATCAC TCTGCAGGCC CTTTCAGAAG CTAACAGAAG GCTATGGATG 
GAAGCCATGG ATGGGAAAGA ACCTATCTAC CACAGCCCTA TAACAAAACA GCAAGAAATG 
GAGCTAAATG AAGTGGGCTT CAAGTTTGTC AGGAAGTGCA TCAATATTAT TGAGACCAAA 
GGGATCAAGA CAGAAGGGTT GTACCGCACT GTGGGCAGCA ATATTCAGGT TCAGAAGCTG 
CTGAATGCCT TTTTTGATCC TAAATGCCCA GGAGATGTTG ATTTTCATAA TAGTGACTGG 
GACATTAAGA CAATCACCAG CTCCTTGAAA TTCTACCTCA GGAATCTTTC TGAACCTGTC 
ATGACCTATA GACTTCACAA AGAGCTGGTC TCTGCTGCCA AGTCTGACAA CCTGGATTAC 
CGCCTAGGAG CTATTCACTC CCTGGTATAT AAGCTACCAG AAAAGAACCG AGAGATGCTG 
GAACTTCTGA TAAGACACTT GGTCAATGTG TGTGAGCACA GCAAAGAGAA TCTTATGACC 
CCCTCCAACA TGGGAGTAAT CTTTGGGCCC ACCCTGATGA GAGCTCAGGA GGACACTGTG 
GCCGCCATGA TGAACATCAA ATTCCAGAAC ATAGTGGTGG AAATACTAAT CGAGCACTTT 
GGCAAGATCT ATTTAGGTCC ACCTGAGGAA AGCGCTGCAC CGCCAGTGCC TCCGCCTCGG 
GTGACAGCAA GAAGGCACAA ACCAATCACG ATTTCAAAGC GCTTGCTGCG AGAAAGGACG 
GTTTTCTATA CTTCTTCCCT GGATGAAAGC GAAGGGGATG CTGACAGTTT CAGCAAAGTG 
CGGCCTCCAG GAGAAAAGCC AACCATCATC CGCCCCCCAG TGAGGCCCCC AGATCCTCCC 
TGCCGGGCAG CTACTCCCCA AAAGCCAGAA CCAAAGCCAG ATATTGTGGC TGGCAATGCG 
GGGGAAATCA CATCATCTGT GGTGGCTTCC AGGACCAGGT TTTTTGAAAC AGCTTCCCGG 
AAAACAGGAA GTTCTCAAGG CAGACTTCCT GGAGATGAAA GTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

OPHN1 ( XM_017029555.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016885044.1 Homo sapiens oligophrenin 1 (OPHN1), transcript variant X4, mRNA.

Price & Availability↑

CloneID	OHu99324
Clone ID Related Accession (Same CDS sequence)	XM_017029555.1
Accession Version	XM_017029555.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1698bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	oligophrenin-1 isoform X4
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000023.11) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGGTCATC CCCCGCTGGA GTTCAGCGAC TGCTACCTGG ACAGCCCCGA TTTCCGCGAG 
AGGCTCAAGT GTTATGAGCA GGAACTGGAG AGGACCAACA AATTCATCAA AGACGTAATC 
AAAGACGGCA ACGCGCTTAT CAGCGCTATG AGAAATTATT CTTCTGCTGT TCAGAAATTT 
TCCCAGACGC TGCAGTCATT TCAGTTTGAT TTCATTGGAG ACACTCTGAC TGATGATGAA 
ATTAACATCG CTGAATCCTT CAAGGAATTT GCTGAATTGC TCAACGAGGT AGAAAATGAG 
AGGATGATGA TGGTACACAA TGCTAGTGAT TTGCTGATTA AACCCTTGGA AAATTTCCGG 
AAGGAACAAA TAGGCTTCAC CAAGGAGCGG AAAAAGAAAT TTGAAAAGGA TGGTGAGAGG 
TTTTATTCTT TACTGGATCG GCACTTACAC CTGTCTTCAA AAAAGAAAGA ATCTCAGTTA 
CAAGAGGCAG ACCTACAGGT GGACAAGGAG AGGCACAATT TTTTCGAGTC CTCTCTTGAT 
TATGTTTATC AAATCCAGGA AGTTCAGGAG TCCAAGAAGT TCAATATTGT GGAGCCTGTC 
TTGGCCTTTC TTCATAGTCT GTTCATTTCT AACAGCCTGA CTGTGGAGCT CACACAGGAT 
TTCCTCCCAT ACAAACAACA GCTCCAACTC AGTTTACAGA ATACAAGAAA TCATTTCTCC 
AGTACCCGGG AAGAGATGGA AGAACTTAAG AAAAGGATGA AAGAAGCTCC CCAGACATGC 
AAACTTCCAG GACAGCCAAC TATTGAAGGC TATCTCTATA CACAAGAGAA ATGGGCTTTA 
GGAATATCCT GGGTGAAATA CTATTGCCAG TATGAGAAAG AGACCAAAAC ACTGACCATG 
ACGCCTATGG AGCAGAAGCC AGGTGCTAAG CAGGGGCCCT TGGACTTAAC ACTGAAGTAC 
TGTGTGAGAA GGAAGACGGA GTCTATCGAC AAGAGGTTCT GTTTTGACAT AGAAACTAAT 
GAAAGGCCAG GAACCATCAC TCTGCAGGCC CTTTCAGAAG CTAACAGAAG GCTATGGATG 
GAAGCCATGG ATGGGAAAGA ACCTATCTAC CACAGCCCTA TAACAAAACA GCAAGAAATG 
GAGCTAAATG AAGTGGGCTT CAAGTTTGTC AGGAAGTGCA TCAATATTAT TGAGACCAAA 
GGGATCAAGA CAGAAGGGTT GTACCGCACT GTGGGCAGCA ATATTCAGGT TCAGAAGCTG 
CTGAATGCCT TTTTTGATCC TAAATGCCCA GGAGATGTTG ATTTTCATAA TAGTGACTGG 
GACATTAAGA CAATCACCAG CTCCTTGAAA TTCTACCTCA GGAATCTTTC TGAACCTGTC 
ATGACCTATA GACTTCACAA AGAGCTGGTC TCTGCTGCCA AGTCTGACAA CCTGGATTAC 
CGCCTAGGAG CTATTCACTC CCTGGTATAT AAGCTACCAG AAAAGAACCG AGAGATGCTG 
GAACTTCTGA TAAGACACTT GGTCAATGTG TGTGAGCACA GCAAAGAGAA TCTTATGACC 
CCCTCCAACA TGGGAGTAAT CTTTGGGCCC ACCCTGATGA GAGCTCAGGA GGACACTGTG 
GCCGCCATGA TGAACATCAA ATTCCAGAAC ATAGTGGTGG AAATACTAAT CGAGCACTTT 
GGCAAGAAAT TGCCATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016885044.1
CDS	365..2062
Translation	MGHPPLEFSDCYLDSPDFRERLKCYEQELERTNKFIKDVIKDGNALISAMRNYSSAVQKFSQTLQSFQFDFIGDTLTDDEINIAESFKEFAELLNEVENERMMMVHNASDLLIKPLENFRKEQIGFTKERKKKFEKDGERFYSLLDRHLHLSSKKKESQLQEADLQVDKERHNFFESSLDYVYQIQEVQESKKFNIVEPVLAFLHSLFISNSLTVELTQDFLPYKQQLQLSLQNTRNHFSSTREEMEELKKRMKEAPQTCKLPGQPTIEGYLYTQEKWALGISWVKYYCQYEKETKTLTMTPMEQKPGAKQGPLDLTLKYCVRRKTESIDKRFCFDIETNERPGTITLQALSEANRRLWMEAMDGKEPIYHSPITKQQEMELNEVGFKFVRKCINIIETKGIKTEGLYRTVGSNIQVQKLLNAFFDPKCPGDVDFHNSDWDIKTITSSLKFYLRNLSEPVMTYRLHKELVSAAKSDNLDYRLGAIHSLVYKLPEKNREMLELLIRHLVNVCEHSKENLMTPSNMGVIFGPTLMRAQEDTVAAMMNIKFQNIVVEILIEHFGKKLP

Target ORF information:

RefSeq Version	XM_017029555.1
Organism	Homo sapiens(human)
Definition	Homo sapiens oligophrenin 1 (OPHN1), transcript variant X4, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017029555.1

ORF Insert Sequence:

ATGGGTCATC CCCCGCTGGA GTTCAGCGAC TGCTACCTGG ACAGCCCCGA TTTCCGCGAG 
AGGCTCAAGT GTTATGAGCA GGAACTGGAG AGGACCAACA AATTCATCAA AGACGTAATC 
AAAGACGGCA ACGCGCTTAT CAGCGCTATG AGAAATTATT CTTCTGCTGT TCAGAAATTT 
TCCCAGACGC TGCAGTCATT TCAGTTTGAT TTCATTGGAG ACACTCTGAC TGATGATGAA 
ATTAACATCG CTGAATCCTT CAAGGAATTT GCTGAATTGC TCAACGAGGT AGAAAATGAG 
AGGATGATGA TGGTACACAA TGCTAGTGAT TTGCTGATTA AACCCTTGGA AAATTTCCGG 
AAGGAACAAA TAGGCTTCAC CAAGGAGCGG AAAAAGAAAT TTGAAAAGGA TGGTGAGAGG 
TTTTATTCTT TACTGGATCG GCACTTACAC CTGTCTTCAA AAAAGAAAGA ATCTCAGTTA 
CAAGAGGCAG ACCTACAGGT GGACAAGGAG AGGCACAATT TTTTCGAGTC CTCTCTTGAT 
TATGTTTATC AAATCCAGGA AGTTCAGGAG TCCAAGAAGT TCAATATTGT GGAGCCTGTC 
TTGGCCTTTC TTCATAGTCT GTTCATTTCT AACAGCCTGA CTGTGGAGCT CACACAGGAT 
TTCCTCCCAT ACAAACAACA GCTCCAACTC AGTTTACAGA ATACAAGAAA TCATTTCTCC 
AGTACCCGGG AAGAGATGGA AGAACTTAAG AAAAGGATGA AAGAAGCTCC CCAGACATGC 
AAACTTCCAG GACAGCCAAC TATTGAAGGC TATCTCTATA CACAAGAGAA ATGGGCTTTA 
GGAATATCCT GGGTGAAATA CTATTGCCAG TATGAGAAAG AGACCAAAAC ACTGACCATG 
ACGCCTATGG AGCAGAAGCC AGGTGCTAAG CAGGGGCCCT TGGACTTAAC ACTGAAGTAC 
TGTGTGAGAA GGAAGACGGA GTCTATCGAC AAGAGGTTCT GTTTTGACAT AGAAACTAAT 
GAAAGGCCAG GAACCATCAC TCTGCAGGCC CTTTCAGAAG CTAACAGAAG GCTATGGATG 
GAAGCCATGG ATGGGAAAGA ACCTATCTAC CACAGCCCTA TAACAAAACA GCAAGAAATG 
GAGCTAAATG AAGTGGGCTT CAAGTTTGTC AGGAAGTGCA TCAATATTAT TGAGACCAAA 
GGGATCAAGA CAGAAGGGTT GTACCGCACT GTGGGCAGCA ATATTCAGGT TCAGAAGCTG 
CTGAATGCCT TTTTTGATCC TAAATGCCCA GGAGATGTTG ATTTTCATAA TAGTGACTGG 
GACATTAAGA CAATCACCAG CTCCTTGAAA TTCTACCTCA GGAATCTTTC TGAACCTGTC 
ATGACCTATA GACTTCACAA AGAGCTGGTC TCTGCTGCCA AGTCTGACAA CCTGGATTAC 
CGCCTAGGAG CTATTCACTC CCTGGTATAT AAGCTACCAG AAAAGAACCG AGAGATGCTG 
GAACTTCTGA TAAGACACTT GGTCAATGTG TGTGAGCACA GCAAAGAGAA TCTTATGACC 
CCCTCCAACA TGGGAGTAAT CTTTGGGCCC ACCCTGATGA GAGCTCAGGA GGACACTGTG 
GCCGCCATGA TGAACATCAA ATTCCAGAAC ATAGTGGTGG AAATACTAAT CGAGCACTTT 
GGCAAGAAAT TGCCATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Large in-frame intragenic deletion of OPHN1 in a male patient with a normal intelligence quotient score.
Clinical dysmorphology26(1)47-49(2017 Jan)
Busa T,Caietta E,Chabrol B,Girard N,Philip N,Missirian C

Oligophrenin-1 regulates number, morphology and synaptic properties of adult-born inhibitory interneurons in the olfactory bulb.
Human molecular genetics25(23)5198-5211(2016 12)
Redolfi N,Galla L,Maset A,Murru L,Savoia E,Zamparo I,Gritti A,Billuart P,Passafaro M,Lodovichi C

Rho Kinase Inhibition Is Essential During In Vitro Neurogenesis and Promotes Phenotypic Rescue of Human Induced Pluripotent Stem Cell-Derived Neurons With Oligophrenin-1 Loss of Function.
Stem cells translational medicine5(7)860-9(2016 Jul)
Compagnucci C,Barresi S,Petrini S,Billuart P,Piccini G,Chiurazzi P,Alfieri P,Bertini E,Zanni G

Fasudil treatment in adult reverses behavioural changes and brain ventricular enlargement in Oligophrenin-1 mouse model of intellectual disability.
Human molecular genetics25(11)2314-2323(2016 06)
Meziane H,Khelfaoui M,Morello N,Hiba B,Calcagno E,Reibel-Foisset S,Selloum M,Chelly J,Humeau Y,Riet F,Zanni G,Herault Y,Bienvenu T,Giustetto M,Billuart P

Oligophrenin-1 is associated with cell adhesion and migration in prostate cancer.
Pathobiology : journal of immunopathology, molecular and cellular biology81(4)190-8(2014)
Goto K,Oue N,Hayashi T,Shinmei S,Sakamoto N,Sentani K,Teishima J,Matsubara A,Yasui W

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OPHN1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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