TIFAB cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	TIFAB
Entrez Gene ID	497189
Full Name	TIFA inhibitor
General protein information	Preferred Names TIFA inhibitor Names TRAF-interacting protein with FHA domain-containing protein B TIFA-like protein TIFA-related protein TIFAB TRAF-interacting protein with forkhead-associated domain, family member B
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 5 Map Location: 5q31.1
Summary	TIFAB associates with TIFA (MIM 609028) and inhibits TIFA-mediated activation of NF-kappa-B (NFKB1; MIM 164011) (Matsumura et al., 2004 [PubMed 15047173]).[supplied by OMIM, Mar 2009].
Disorder MIM:	612663

mRNA and Protein(s)

mRNA	Protein	Name
NM_001099221.2	NP_001092691.1	TRAF-interacting protein with FHA domain-containing protein B
NM_001099221.1	NP_001092691.1	TRAF-interacting protein with FHA domain-containing protein B

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Tifab	NP_666088.1
Rattus norvegicus (Norway rat)	Tifab	NP_001020200.1
Homo sapiens (human)	TIFAB	NP_001092691.1
Canis lupus familiaris (dog)	TIFAB	XP_005626616.1
Bos taurus (cattle)	TIFAB	XP_002689248.2
Pan troglodytes (chimpanzee)	TIFAB	XP_527016.3
	LOC715045	XP_001105096.2

Gene Ontology
Bibliography

Related articles in PubMed

Loss of Tifab, a del(5q) MDS gene, alters hematopoiesis through derepression of Toll-like receptor-TRAF6 signaling.
Varney ME, Niederkorn M, Konno H, Matsumura T, Gohda J, Yoshida N, Akiyama T, Christie S, Fang J, Miller D, Jerez A, Karsan A, Maciejewski JP, Meetei RA, Inoue J, Starczynowski DT
The Journal of experimental medicine212(11)1967-85(2015 Oct)

A boy with homozygous microdeletion of NEUROG1 presents with a congenital cranial dysinnervation disorder [Moebius syndrome variant].
Schr?der JC, L??ig AK, Galetzka D, Peters A, Castle JC, Diederich S, Zechner U, M?ller-Forell W, Keilmann A, Bartsch O
Behavioral and brain functions : BBF97(2013 Feb)

TIFAB inhibits TIFA, TRAF-interacting protein with a forkhead-associated domain.
Matsumura T, Semba K, Azuma S, Ikawa S, Gohda J, Akiyama T, Inoue J
Biochemical and biophysical research communications317(1)230-4(2004 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

TIFAB loss increases TRAF6 protein and the dynamic range of TLR4 signaling
Title: Loss of Tifab, a del(5q) MDS gene, alters hematopoiesis through derepression of Toll-like receptor-TRAF6 signaling.

The following TIFAB gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TIFAB cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu30842	NM_001099221.2 Latest version!	Homo sapiens TIFA inhibitor (TIFAB), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
View Old Accession Versions >>
OHu30842	NM_001099221.1	Homo sapiens TIFA inhibitor (TIFAB), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

TIFAB ( NM_001099221.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001092691.1 Homo sapiens TIFA inhibitor (TIFAB), mRNA.

Price & Availability↑

CloneID	OHu30842
Clone ID Related Accession (Same CDS sequence)	NM_001099221.2 , NM_001099221.1
Accession Version	NM_001099221.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 486bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-30
Organism	Homo sapiens(human)
Product	TRAF-interacting protein with FHA domain-containing protein B
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AB161513.1, AK131088.1, BX119085.1 and AC022092.8. On Nov 22, 2018 this sequence version replaced NM_001099221.1. ##Evidence-Data-START## Transcript exon combination :: AK131088.1, AB161513.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000537858.2/ ENSP00000440509.1 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGAGAAGC CCCTCACCGT CCTGCGAGTG AGCCTGTACC ATCCCACGCT GGGCCCATCT 
GCCTTTGCCA ATGTCCCACC ACGGCTGCAG CATGATACCA GCCCTCTGCT TCTCGGACGG 
GGGCAGGACG CCCACCTCCA GCTGCAGCTC CCTCGCCTCT CCCGCCGTCA CCTGTCCCTG 
GAGCCCTACC TGGAGAAAGG CAGTGCCCTG CTGGCCTTCT GCCTCAAGGC CCTGAGCCGC 
AAGGGCTGTG TGTGGGTCAA TGGGCTGACG CTGAGGTACC TGGAGCAGGT CCCCCTGAGC 
ACCGTCAACA GGGTCTCCTT CTCAGGCATC CAGATGCTGG TTCGCGTAGA AGAAGGCACA 
TCCCTGGAGG CTTTTGTCTG CTATTTCCAT GTCAGCCCTT CACCCCTGAT TTACAGACCT 
GAGGCTGAGG AAACTGACGA ATGGGAAGGC ATCTCCCAGG GGCAGCCTCC CCCTGGTTCA 
GGGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001092691.1
CDS	154..639
Translation	MEKPLTVLRVSLYHPTLGPSAFANVPPRLQHDTSPLLLGRGQDAHLQLQLPRLSRRHLSLEPYLEKGSALLAFCLKALSRKGCVWVNGLTLRYLEQVPLSTVNRVSFSGIQMLVRVEEGTSLEAFVCYFHVSPSPLIYRPEAEETDEWEGISQGQPPPGSG

Target ORF information:

RefSeq Version	NM_001099221.2
Organism	Homo sapiens(human)
Definition	Homo sapiens TIFA inhibitor (TIFAB), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001099221.2

ORF Insert Sequence:

ATGGAGAAGC CCCTCACCGT CCTGCGAGTG AGCCTGTACC ATCCCACGCT GGGCCCATCT 
GCCTTTGCCA ATGTCCCACC ACGGCTGCAG CATGATACCA GCCCTCTGCT TCTCGGACGG 
GGGCAGGACG CCCACCTCCA GCTGCAGCTC CCTCGCCTCT CCCGCCGTCA CCTGTCCCTG 
GAGCCCTACC TGGAGAAAGG CAGTGCCCTG CTGGCCTTCT GCCTCAAGGC CCTGAGCCGC 
AAGGGCTGTG TGTGGGTCAA TGGGCTGACG CTGAGGTACC TGGAGCAGGT CCCCCTGAGC 
ACCGTCAACA GGGTCTCCTT CTCAGGCATC CAGATGCTGG TTCGCGTAGA AGAAGGCACA 
TCCCTGGAGG CTTTTGTCTG CTATTTCCAT GTCAGCCCTT CACCCCTGAT TTACAGACCT 
GAGGCTGAGG AAACTGACGA ATGGGAAGGC ATCTCCCAGG GGCAGCCTCC CCCTGGTTCA 
GGGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TIFAB ( NM_001099221.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001092691.1 Homo sapiens TIFA inhibitor (TIFAB), mRNA.

Price & Availability↑

CloneID	OHu30842
Clone ID Related Accession (Same CDS sequence)	NM_001099221.2 , NM_001099221.1
Accession Version	NM_001099221.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 486bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	TRAF-interacting protein with FHA domain-containing protein B
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AB161513.1, AK131088.1 and BX119085.1. On or before Jun 29, 2007 this sequence version replaced XM_938912.1, XM_928467.2. ##Evidence-Data-START## Transcript exon combination :: AB161513.1, AK131088.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAGAAGC CCCTCACCGT CCTGCGAGTG AGCCTGTACC ATCCCACGCT GGGCCCATCT 
GCCTTTGCCA ATGTCCCACC ACGGCTGCAG CATGATACCA GCCCTCTGCT TCTCGGACGG 
GGGCAGGACG CCCACCTCCA GCTGCAGCTC CCTCGCCTCT CCCGCCGTCA CCTGTCCCTG 
GAGCCCTACC TGGAGAAAGG CAGTGCCCTG CTGGCCTTCT GCCTCAAGGC CCTGAGCCGC 
AAGGGCTGTG TGTGGGTCAA TGGGCTGACG CTGAGGTACC TGGAGCAGGT CCCCCTGAGC 
ACCGTCAACA GGGTCTCCTT CTCAGGCATC CAGATGCTGG TTCGCGTAGA AGAAGGCACA 
TCCCTGGAGG CTTTTGTCTG CTATTTCCAT GTCAGCCCTT CACCCCTGAT TTACAGACCT 
GAGGCTGAGG AAACTGACGA ATGGGAAGGC ATCTCCCAGG GGCAGCCTCC CCCTGGTTCA 
GGGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001092691.1
CDS	202..687
Translation	MEKPLTVLRVSLYHPTLGPSAFANVPPRLQHDTSPLLLGRGQDAHLQLQLPRLSRRHLSLEPYLEKGSALLAFCLKALSRKGCVWVNGLTLRYLEQVPLSTVNRVSFSGIQMLVRVEEGTSLEAFVCYFHVSPSPLIYRPEAEETDEWEGISQGQPPPGSG

Target ORF information:

RefSeq Version	NM_001099221.1
Organism	Homo sapiens(human)
Definition	Homo sapiens TIFA inhibitor (TIFAB), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001099221.1

ORF Insert Sequence:

ATGGAGAAGC CCCTCACCGT CCTGCGAGTG AGCCTGTACC ATCCCACGCT GGGCCCATCT 
GCCTTTGCCA ATGTCCCACC ACGGCTGCAG CATGATACCA GCCCTCTGCT TCTCGGACGG 
GGGCAGGACG CCCACCTCCA GCTGCAGCTC CCTCGCCTCT CCCGCCGTCA CCTGTCCCTG 
GAGCCCTACC TGGAGAAAGG CAGTGCCCTG CTGGCCTTCT GCCTCAAGGC CCTGAGCCGC 
AAGGGCTGTG TGTGGGTCAA TGGGCTGACG CTGAGGTACC TGGAGCAGGT CCCCCTGAGC 
ACCGTCAACA GGGTCTCCTT CTCAGGCATC CAGATGCTGG TTCGCGTAGA AGAAGGCACA 
TCCCTGGAGG CTTTTGTCTG CTATTTCCAT GTCAGCCCTT CACCCCTGAT TTACAGACCT 
GAGGCTGAGG AAACTGACGA ATGGGAAGGC ATCTCCCAGG GGCAGCCTCC CCCTGGTTCA 
GGGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Loss of Tifab, a del(5q) MDS gene, alters hematopoiesis through derepression of Toll-like receptor-TRAF6 signaling.
The Journal of experimental medicine212(11)1967-85(2015 Oct)
Varney ME,Niederkorn M,Konno H,Matsumura T,Gohda J,Yoshida N,Akiyama T,Christie S,Fang J,Miller D,Jerez A,Karsan A,Maciejewski JP,Meetei RA,Inoue J,Starczynowski DT

A boy with homozygous microdeletion of NEUROG1 presents with a congenital cranial dysinnervation disorder [Moebius syndrome variant].
Behavioral and brain functions : BBF97(2013 Feb)
Schr?der JC,L??ig AK,Galetzka D,Peters A,Castle JC,Diederich S,Zechner U,M?ller-Forell W,Keilmann A,Bartsch O

TIFAB inhibits TIFA, TRAF-interacting protein with a forkhead-associated domain.
Biochemical and biophysical research communications317(1)230-4(2004 Apr)
Matsumura T,Semba K,Azuma S,Ikawa S,Gohda J,Akiyama T,Inoue J

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TIFAB cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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