Gene Symbol | ODC1 |
Entrez Gene ID | 4953 |
Full Name | ornithine decarboxylase 1 |
Synonyms | ODC |
General protein information |
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Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Summary | This gene encodes the rate-limiting enzyme of the polyamine biosynthesis pathway which catalyzes ornithine to putrescine. The activity level for the enzyme varies in response to growth-promoting stimuli and exhibits a high turnover rate in comparison to other mammalian proteins. Originally localized to both chromosomes 2 and 7, the gene encoding this enzyme has been determined to be located on 2p25, with a pseudogene located on 7q31-qter. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Dec 2013]. |
Disorder MIM: | |
Disorder Html: | {Colonic adenoma recurrence, reduced risk of}, 114500 (3) |