Gene Symbol | ROR1 |
Entrez Gene ID | 4919 |
Full Name | receptor tyrosine kinase like orphan receptor 1 |
Synonyms | NTRKR1,dJ537F10.1 |
General protein information |
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Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Summary | This gene encodes a receptor tyrosine kinase-like orphan receptor that modulates neurite growth in the central nervous system. The encoded protein is a glycosylated type I membrane protein that belongs to the ROR subfamily of cell surface receptors. It is a pseudokinase that lacks catalytic activity and may interact with the non-canonical Wnt signalling pathway. This gene is highly expressed during early embryonic development but expressed at very low levels in adult tissues. Increased expression of this gene is associated with B-cell chronic lymphocytic leukaemia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2012]. |
Disorder MIM: | |
Disorder Html: | ?Deafness, autosomal recessive 108, 617654 (3) |