NTF3 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	NTF3
Entrez Gene ID	4908
Full Name	neurotrophin 3
Synonyms	HDNF,NGF-2,NGF2,NT-3,NT3
General protein information	Preferred Names neurotrophin 3 Names neurotrophin-3 nerve growth factor 2 neurotrophic factor
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 12 Map Location: 12p13.31
Summary	The protein encoded by this gene is a member of the neurotrophin family, that controls survival and differentiation of mammalian neurons. This protein is closely related to both nerve growth factor and brain-derived neurotrophic factor. It may be involved in the maintenance of the adult nervous system, and may affect development of neurons in the embryo when it is expressed in human placenta. NTF3-deficient mice generated by gene targeting display severe movement defects of the limbs. The mature peptide of this protein is identical in all mammals examined including human, pig, rat and mouse. [provided by RefSeq, Jul 2008].
Disorder MIM:	162660

mRNA and Protein(s)

mRNA	Protein	Name
NM_001102654.1	NP_001096124.1	neurotrophin-3 isoform 1 preproprotein
XM_011520963.2	XP_011519265.1	neurotrophin-3 isoform X1
NM_002527.4	NP_002518.1	neurotrophin-3 isoform 2 preproprotein
XM_011520963.1	XP_011519265.1	neurotrophin-3 isoform X1
NM_001102654.2	NP_001096124.1	neurotrophin-3 isoform 1 preproprotein

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Ntf3	NP_001157507.1
Gallus gallus (chicken)	NTF3	NP_001103232.1
Homo sapiens (human)	NTF3	NP_001096124.1
Pan troglodytes (chimpanzee)	NTF3	XP_522331.2
Rattus norvegicus (Norway rat)	Ntf3	NP_001257798.1
Danio rerio (zebrafish)	ntf3	XP_697445.5
Xenopus tropicalis (tropical clawed frog)	ntf3	NP_001016370.1
	NTF3	XP_001118191.2
Canis lupus familiaris (dog)	NTF3	XP_003433523.1
Bos taurus (cattle)	NTF3	NP_001071456.1

Gene Ontology
Bibliography

Related articles in PubMed

Brain-derived neurotrophic factor (BDNF) and neurotrophin 3 (NT3) levels in post-mortem brain tissue from patients with depression compared to healthy individuals?-?a proof of concept study.
Sheldrick A, Camara S, Ilieva M, Riederer P, Michel TM
European psychiatry : the journal of the Association of European Psychiatrists4665-71(2017 Oct)

Autophagy and TrkC/NT-3 signaling joined forces boost the hypoxic glioblastoma cell survival.
Jawhari S, Bessette B, Hombourger S, Durand K, Lacroix A, Labrousse F, Jauberteau MO, Ratinaud MH, Verdier M
Carcinogenesis38(6)592-603(2017 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

NT-3 has been shown to be both an osteogenic and angiogenic factor, and can also enhance expression of the key osteogenic factor, BMP-2, as well as the major angiogenic factor, VEGF, to promote bone formation, vascularization, and bone healing
Title: Roles of neurotrophins in skeletal tissue formation and healing.

High expression of NT-3 is associated with glioblastoma.
Title: Autophagy and TrkC/NT-3 signaling joined forces boost the hypoxic glioblastoma cell survival.

NT3 upregulates cellular proliferation, extracellular matrix protein production, and collagen deposition in human aortic valve interstitial cells through the Trk-Akt-cyclin D1 cascade.
Title: Neurotrophin 3 upregulates proliferation and collagen production in human aortic valve interstitial cells: a potential role in aortic valve sclerosis.

The analysis of covariance (ANCOVA) indicated that the mean serum GDNF and NTF3 levels of ADHD patients were significantly higher than that of controls. However, serum BDNF and NGF levels did not show any significant differences between groups. These results suggest that elevated serum GDNF and NTF3 levels may be related to ADHD in children.
Title: Serum brain-derived neurotrophic factor, glial-derived neurotrophic factor, nerve growth factor, and neurotrophin-3 levels in children with attention-deficit/hyperactivity disorder.

All patients had serum neurotrophin (NT-3, BDNF, NGF) concentrations determined.
Title: Melatonin and neurotrophins NT-3, BDNF, NGF in patients with varying levels of depression severity.

The following NTF3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the NTF3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu13469	NM_002527.4 Latest version!	Homo sapiens neurotrophin 3 (NTF3), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu13469	XM_011520963.2 Latest version!	Homo sapiens neurotrophin 3 (NTF3), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu13378	NM_001102654.2 Latest version!	Homo sapiens neurotrophin 3 (NTF3), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
View Old Accession Versions >>
OHu13469	XM_011520963.1	Homo sapiens neurotrophin 3 (NTF3), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu13378	NM_001102654.1	Homo sapiens neurotrophin 3 (NTF3), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

NTF3 ( NM_002527.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_002518.1 Homo sapiens neurotrophin 3 (NTF3), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu13469
Clone ID Related Accession (Same CDS sequence)	XM_011520963.2 , NM_002527.4 , XM_011520963.1
Accession Version	NM_002527.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 774bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-26
Organism	Homo sapiens(human)
Product	neurotrophin-3 isoform 2 preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC069773.1 and CD672441.1. On Aug 31, 2007 this sequence version replaced NM_002527.3. Transcript Variant: This variant (2) has an alternate 5' sequence and uses a downstream AUG start codon, as compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. COMPLETENESS: complete on the 3' end.

ATGTCCATCT TGTTTTATGT GATATTTCTC GCTTATCTCC GTGGCATCCA AGGTAACAAC 
ATGGATCAAA GGAGTTTGCC AGAAGACTCG CTCAATTCCC TCATTATTAA GCTGATCCAG 
GCAGATATTT TGAAAAACAA GCTCTCCAAG CAGATGGTGG ACGTTAAGGA AAATTACCAG 
AGCACCCTGC CCAAAGCTGA GGCTCCCCGA GAGCCGGAGC GGGGAGGGCC CGCCAAGTCA 
GCATTCCAGC CGGTGATTGC AATGGACACC GAACTGCTGC GACAACAGAG ACGCTACAAC 
TCACCGCGGG TCCTGCTGAG CGACAGCACC CCCTTGGAGC CCCCGCCCTT GTATCTCATG 
GAGGATTACG TGGGCAGCCC CGTGGTGGCG AACAGAACAT CACGGCGGAA ACGGTACGCG 
GAGCATAAGA GTCACCGAGG GGAGTACTCG GTATGTGACA GTGAGAGTCT GTGGGTGACC 
GACAAGTCAT CGGCCATCGA CATTCGGGGA CACCAGGTCA CGGTGCTGGG GGAGATCAAA 
ACGGGCAACT CTCCCGTCAA ACAATATTTT TATGAAACGC GATGTAAGGA AGCCAGGCCG 
GTCAAAAACG GTTGCAGGGG TATTGATGAT AAACACTGGA ACTCTCAGTG CAAAACATCC 
CAAACCTACG TCCGAGCACT GACTTCAGAG AACAATAAAC TCGTGGGCTG GCGGTGGATA 
CGGATAGACA CGTCCTGTGT GTGTGCCTTG TCGAGAAAAA TCGGAAGAAC ATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002518.1
CDS	84..857
Translation	MSILFYVIFLAYLRGIQGNNMDQRSLPEDSLNSLIIKLIQADILKNKLSKQMVDVKENYQSTLPKAEAPREPERGGPAKSAFQPVIAMDTELLRQQRRYNSPRVLLSDSTPLEPPPLYLMEDYVGSPVVANRTSRRKRYAEHKSHRGEYSVCDSESLWVTDKSSAIDIRGHQVTVLGEIKTGNSPVKQYFYETRCKEARPVKNGCRGIDDKHWNSQCKTSQTYVRALTSENNKLVGWRWIRIDTSCVCALSRKIGRT

Target ORF information:

RefSeq Version	NM_002527.4
Organism	Homo sapiens(human)
Definition	Homo sapiens neurotrophin 3 (NTF3), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002527.4

ORF Insert Sequence:

ATGTCCATCT TGTTTTATGT GATATTTCTC GCTTATCTCC GTGGCATCCA AGGTAACAAC 
ATGGATCAAA GGAGTTTGCC AGAAGACTCG CTCAATTCCC TCATTATTAA GCTGATCCAG 
GCAGATATTT TGAAAAACAA GCTCTCCAAG CAGATGGTGG ACGTTAAGGA AAATTACCAG 
AGCACCCTGC CCAAAGCTGA GGCTCCCCGA GAGCCGGAGC GGGGAGGGCC CGCCAAGTCA 
GCATTCCAGC CGGTGATTGC AATGGACACC GAACTGCTGC GACAACAGAG ACGCTACAAC 
TCACCGCGGG TCCTGCTGAG CGACAGCACC CCCTTGGAGC CCCCGCCCTT GTATCTCATG 
GAGGATTACG TGGGCAGCCC CGTGGTGGCG AACAGAACAT CACGGCGGAA ACGGTACGCG 
GAGCATAAGA GTCACCGAGG GGAGTACTCG GTATGTGACA GTGAGAGTCT GTGGGTGACC 
GACAAGTCAT CGGCCATCGA CATTCGGGGA CACCAGGTCA CGGTGCTGGG GGAGATCAAA 
ACGGGCAACT CTCCCGTCAA ACAATATTTT TATGAAACGC GATGTAAGGA AGCCAGGCCG 
GTCAAAAACG GTTGCAGGGG TATTGATGAT AAACACTGGA ACTCTCAGTG CAAAACATCC 
CAAACCTACG TCCGAGCACT GACTTCAGAG AACAATAAAC TCGTGGGCTG GCGGTGGATA 
CGGATAGACA CGTCCTGTGT GTGTGCCTTG TCGAGAAAAA TCGGAAGAAC ATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

NTF3 ( XM_011520963.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_011519265.1 Homo sapiens neurotrophin 3 (NTF3), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu13469
Clone ID Related Accession (Same CDS sequence)	XM_011520963.2 , NM_002527.4 , XM_011520963.1
Accession Version	XM_011520963.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 774bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	neurotrophin-3 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000012.12) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011520963.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTCCATCT TGTTTTATGT GATATTTCTC GCTTATCTCC GTGGCATCCA AGGTAACAAC 
ATGGATCAAA GGAGTTTGCC AGAAGACTCG CTCAATTCCC TCATTATTAA GCTGATCCAG 
GCAGATATTT TGAAAAACAA GCTCTCCAAG CAGATGGTGG ACGTTAAGGA AAATTACCAG 
AGCACCCTGC CCAAAGCTGA GGCTCCCCGA GAGCCGGAGC GGGGAGGGCC CGCCAAGTCA 
GCATTCCAGC CGGTGATTGC AATGGACACC GAACTGCTGC GACAACAGAG ACGCTACAAC 
TCACCGCGGG TCCTGCTGAG CGACAGCACC CCCTTGGAGC CCCCGCCCTT GTATCTCATG 
GAGGATTACG TGGGCAGCCC CGTGGTGGCG AACAGAACAT CACGGCGGAA ACGGTACGCG 
GAGCATAAGA GTCACCGAGG GGAGTACTCG GTATGTGACA GTGAGAGTCT GTGGGTGACC 
GACAAGTCAT CGGCCATCGA CATTCGGGGA CACCAGGTCA CGGTGCTGGG GGAGATCAAA 
ACGGGCAACT CTCCCGTCAA ACAATATTTT TATGAAACGC GATGTAAGGA AGCCAGGCCG 
GTCAAAAACG GTTGCAGGGG TATTGATGAT AAACACTGGA ACTCTCAGTG CAAAACATCC 
CAAACCTACG TCCGAGCACT GACTTCAGAG AACAATAAAC TCGTGGGCTG GCGGTGGATA 
CGGATAGACA CGTCCTGTGT GTGTGCCTTG TCGAGAAAAA TCGGAAGAAC ATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011519265.1
CDS	295..1068
Translation	MSILFYVIFLAYLRGIQGNNMDQRSLPEDSLNSLIIKLIQADILKNKLSKQMVDVKENYQSTLPKAEAPREPERGGPAKSAFQPVIAMDTELLRQQRRYNSPRVLLSDSTPLEPPPLYLMEDYVGSPVVANRTSRRKRYAEHKSHRGEYSVCDSESLWVTDKSSAIDIRGHQVTVLGEIKTGNSPVKQYFYETRCKEARPVKNGCRGIDDKHWNSQCKTSQTYVRALTSENNKLVGWRWIRIDTSCVCALSRKIGRT

Target ORF information:

RefSeq Version	XM_011520963.2
Organism	Homo sapiens(human)
Definition	Homo sapiens neurotrophin 3 (NTF3), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011520963.2

ORF Insert Sequence:

ATGTCCATCT TGTTTTATGT GATATTTCTC GCTTATCTCC GTGGCATCCA AGGTAACAAC 
ATGGATCAAA GGAGTTTGCC AGAAGACTCG CTCAATTCCC TCATTATTAA GCTGATCCAG 
GCAGATATTT TGAAAAACAA GCTCTCCAAG CAGATGGTGG ACGTTAAGGA AAATTACCAG 
AGCACCCTGC CCAAAGCTGA GGCTCCCCGA GAGCCGGAGC GGGGAGGGCC CGCCAAGTCA 
GCATTCCAGC CGGTGATTGC AATGGACACC GAACTGCTGC GACAACAGAG ACGCTACAAC 
TCACCGCGGG TCCTGCTGAG CGACAGCACC CCCTTGGAGC CCCCGCCCTT GTATCTCATG 
GAGGATTACG TGGGCAGCCC CGTGGTGGCG AACAGAACAT CACGGCGGAA ACGGTACGCG 
GAGCATAAGA GTCACCGAGG GGAGTACTCG GTATGTGACA GTGAGAGTCT GTGGGTGACC 
GACAAGTCAT CGGCCATCGA CATTCGGGGA CACCAGGTCA CGGTGCTGGG GGAGATCAAA 
ACGGGCAACT CTCCCGTCAA ACAATATTTT TATGAAACGC GATGTAAGGA AGCCAGGCCG 
GTCAAAAACG GTTGCAGGGG TATTGATGAT AAACACTGGA ACTCTCAGTG CAAAACATCC 
CAAACCTACG TCCGAGCACT GACTTCAGAG AACAATAAAC TCGTGGGCTG GCGGTGGATA 
CGGATAGACA CGTCCTGTGT GTGTGCCTTG TCGAGAAAAA TCGGAAGAAC ATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

NTF3 ( XM_011520963.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_011519265.1 Homo sapiens neurotrophin 3 (NTF3), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu13469
Clone ID Related Accession (Same CDS sequence)	XM_011520963.2 , NM_002527.4 , XM_011520963.1
Accession Version	XM_011520963.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 774bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-03-11
Organism	Homo sapiens(Human)
Product	neurotrophin-3 isoform X1
Comment

ATGTCCATCT TGTTTTATGT GATATTTCTC GCTTATCTCC GTGGCATCCA AGGTAACAAC 
ATGGATCAAA GGAGTTTGCC AGAAGACTCG CTCAATTCCC TCATTATTAA GCTGATCCAG 
GCAGATATTT TGAAAAACAA GCTCTCCAAG CAGATGGTGG ACGTTAAGGA AAATTACCAG 
AGCACCCTGC CCAAAGCTGA GGCTCCCCGA GAGCCGGAGC GGGGAGGGCC CGCCAAGTCA 
GCATTCCAGC CGGTGATTGC AATGGACACC GAACTGCTGC GACAACAGAG ACGCTACAAC 
TCACCGCGGG TCCTGCTGAG CGACAGCACC CCCTTGGAGC CCCCGCCCTT GTATCTCATG 
GAGGATTACG TGGGCAGCCC CGTGGTGGCG AACAGAACAT CACGGCGGAA ACGGTACGCG 
GAGCATAAGA GTCACCGAGG GGAGTACTCG GTATGTGACA GTGAGAGTCT GTGGGTGACC 
GACAAGTCAT CGGCCATCGA CATTCGGGGA CACCAGGTCA CGGTGCTGGG GGAGATCAAA 
ACGGGCAACT CTCCCGTCAA ACAATATTTT TATGAAACGC GATGTAAGGA AGCCAGGCCG 
GTCAAAAACG GTTGCAGGGG TATTGATGAT AAACACTGGA ACTCTCAGTG CAAAACATCC 
CAAACCTACG TCCGAGCACT GACTTCAGAG AACAATAAAC TCGTGGGCTG GCGGTGGATA 
CGGATAGACA CGTCCTGTGT GTGTGCCTTG TCGAGAAAAA TCGGAAGAAC ATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011519265.1
Translation	MSILFYVIFLAYLRGIQGNNMDQRSLPEDSLNSLIIKLIQADILKNKLSKQMVDVKENYQSTLPKAEAPREPERGGPAKSAFQPVIAMDTELLRQQRRYNSPRVLLSDSTPLEPPPLYLMEDYVGSPVVANRTSRRKRYAEHKSHRGEYSVCDSESLWVTDKSSAIDIRGHQVTVLGEIKTGNSPVKQYFYETRCKEARPVKNGCRGIDDKHWNSQCKTSQTYVRALTSENNKLVGWRWIRIDTSCVCALSRKIGRT

Target ORF information:

RefSeq Version	XM_011520963.1
Organism	Homo sapiens(Human)
Definition	Homo sapiens neurotrophin 3 (NTF3), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011520963.1

ORF Insert Sequence:

ATGTCCATCT TGTTTTATGT GATATTTCTC GCTTATCTCC GTGGCATCCA AGGTAACAAC 
ATGGATCAAA GGAGTTTGCC AGAAGACTCG CTCAATTCCC TCATTATTAA GCTGATCCAG 
GCAGATATTT TGAAAAACAA GCTCTCCAAG CAGATGGTGG ACGTTAAGGA AAATTACCAG 
AGCACCCTGC CCAAAGCTGA GGCTCCCCGA GAGCCGGAGC GGGGAGGGCC CGCCAAGTCA 
GCATTCCAGC CGGTGATTGC AATGGACACC GAACTGCTGC GACAACAGAG ACGCTACAAC 
TCACCGCGGG TCCTGCTGAG CGACAGCACC CCCTTGGAGC CCCCGCCCTT GTATCTCATG 
GAGGATTACG TGGGCAGCCC CGTGGTGGCG AACAGAACAT CACGGCGGAA ACGGTACGCG 
GAGCATAAGA GTCACCGAGG GGAGTACTCG GTATGTGACA GTGAGAGTCT GTGGGTGACC 
GACAAGTCAT CGGCCATCGA CATTCGGGGA CACCAGGTCA CGGTGCTGGG GGAGATCAAA 
ACGGGCAACT CTCCCGTCAA ACAATATTTT TATGAAACGC GATGTAAGGA AGCCAGGCCG 
GTCAAAAACG GTTGCAGGGG TATTGATGAT AAACACTGGA ACTCTCAGTG CAAAACATCC 
CAAACCTACG TCCGAGCACT GACTTCAGAG AACAATAAAC TCGTGGGCTG GCGGTGGATA 
CGGATAGACA CGTCCTGTGT GTGTGCCTTG TCGAGAAAAA TCGGAAGAAC ATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

NTF3 ( NM_001102654.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001096124.1 Homo sapiens neurotrophin 3 (NTF3), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu13378
Clone ID Related Accession (Same CDS sequence)	NM_001102654.1 , NM_001102654.2
Accession Version	NM_001102654.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 813bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-17
Organism	Homo sapiens(human)
Product	neurotrophin-3 isoform 1 preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BU939830.1, CN267386.1, BC069773.1 and CD672441.1. This sequence is a reference standard in the RefSeqGene project. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK293895.1, AL552418.3 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1968832 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGTTACTT TTGCCACGAT CTTACAGGTG AACAAGGTGA TGTCCATCTT GTTTTATGTG 
ATATTTCTCG CTTATCTCCG TGGCATCCAA GGTAACAACA TGGATCAAAG GAGTTTGCCA 
GAAGACTCGC TCAATTCCCT CATTATTAAG CTGATCCAGG CAGATATTTT GAAAAACAAG 
CTCTCCAAGC AGATGGTGGA CGTTAAGGAA AATTACCAGA GCACCCTGCC CAAAGCTGAG 
GCTCCCCGAG AGCCGGAGCG GGGAGGGCCC GCCAAGTCAG CATTCCAGCC GGTGATTGCA 
ATGGACACCG AACTGCTGCG ACAACAGAGA CGCTACAACT CACCGCGGGT CCTGCTGAGC 
GACAGCACCC CCTTGGAGCC CCCGCCCTTG TATCTCATGG AGGATTACGT GGGCAGCCCC 
GTGGTGGCGA ACAGAACATC ACGGCGGAAA CGGTACGCGG AGCATAAGAG TCACCGAGGG 
GAGTACTCGG TATGTGACAG TGAGAGTCTG TGGGTGACCG ACAAGTCATC GGCCATCGAC 
ATTCGGGGAC ACCAGGTCAC GGTGCTGGGG GAGATCAAAA CGGGCAACTC TCCCGTCAAA 
CAATATTTTT ATGAAACGCG ATGTAAGGAA GCCAGGCCGG TCAAAAACGG TTGCAGGGGT 
ATTGATGATA AACACTGGAA CTCTCAGTGC AAAACATCCC AAACCTACGT CCGAGCACTG 
ACTTCAGAGA ACAATAAACT CGTGGGCTGG CGGTGGATAC GGATAGACAC GTCCTGTGTG 
TGTGCCTTGT CGAGAAAAAT CGGAAGAACA TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001096124.1
CDS	212..1024
Translation	MVTFATILQVNKVMSILFYVIFLAYLRGIQGNNMDQRSLPEDSLNSLIIKLIQADILKNKLSKQMVDVKENYQSTLPKAEAPREPERGGPAKSAFQPVIAMDTELLRQQRRYNSPRVLLSDSTPLEPPPLYLMEDYVGSPVVANRTSRRKRYAEHKSHRGEYSVCDSESLWVTDKSSAIDIRGHQVTVLGEIKTGNSPVKQYFYETRCKEARPVKNGCRGIDDKHWNSQCKTSQTYVRALTSENNKLVGWRWIRIDTSCVCALSRKIGRT

Target ORF information:

RefSeq Version	NM_001102654.1
Organism	Homo sapiens(human)
Definition	Homo sapiens neurotrophin 3 (NTF3), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001102654.1

ORF Insert Sequence:

ATGGTTACTT TTGCCACGAT CTTACAGGTG AACAAGGTGA TGTCCATCTT GTTTTATGTG 
ATATTTCTCG CTTATCTCCG TGGCATCCAA GGTAACAACA TGGATCAAAG GAGTTTGCCA 
GAAGACTCGC TCAATTCCCT CATTATTAAG CTGATCCAGG CAGATATTTT GAAAAACAAG 
CTCTCCAAGC AGATGGTGGA CGTTAAGGAA AATTACCAGA GCACCCTGCC CAAAGCTGAG 
GCTCCCCGAG AGCCGGAGCG GGGAGGGCCC GCCAAGTCAG CATTCCAGCC GGTGATTGCA 
ATGGACACCG AACTGCTGCG ACAACAGAGA CGCTACAACT CACCGCGGGT CCTGCTGAGC 
GACAGCACCC CCTTGGAGCC CCCGCCCTTG TATCTCATGG AGGATTACGT GGGCAGCCCC 
GTGGTGGCGA ACAGAACATC ACGGCGGAAA CGGTACGCGG AGCATAAGAG TCACCGAGGG 
GAGTACTCGG TATGTGACAG TGAGAGTCTG TGGGTGACCG ACAAGTCATC GGCCATCGAC 
ATTCGGGGAC ACCAGGTCAC GGTGCTGGGG GAGATCAAAA CGGGCAACTC TCCCGTCAAA 
CAATATTTTT ATGAAACGCG ATGTAAGGAA GCCAGGCCGG TCAAAAACGG TTGCAGGGGT 
ATTGATGATA AACACTGGAA CTCTCAGTGC AAAACATCCC AAACCTACGT CCGAGCACTG 
ACTTCAGAGA ACAATAAACT CGTGGGCTGG CGGTGGATAC GGATAGACAC GTCCTGTGTG 
TGTGCCTTGT CGAGAAAAAT CGGAAGAACA TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

NTF3 ( NM_001102654.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001096124.1 Homo sapiens neurotrophin 3 (NTF3), transcript variant 1, mRNA.

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CloneID	OHu13378
Clone ID Related Accession (Same CDS sequence)	NM_001102654.1 , NM_001102654.2
Accession Version	NM_001102654.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 813bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Homo sapiens(human)
Product	neurotrophin-3 isoform 1 preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC007848.11, BU939830.1, CN267386.1, BC069773.1 and CD672441.1. This sequence is a reference standard in the RefSeqGene project. On Nov 22, 2018 this sequence version replaced NM_001102654.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR5189652.232075.1, SRR3476690.165428.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1968832 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000423158.4/ ENSP00000397297.2 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGTTACTT TTGCCACGAT CTTACAGGTG AACAAGGTGA TGTCCATCTT GTTTTATGTG 
ATATTTCTCG CTTATCTCCG TGGCATCCAA GGTAACAACA TGGATCAAAG GAGTTTGCCA 
GAAGACTCGC TCAATTCCCT CATTATTAAG CTGATCCAGG CAGATATTTT GAAAAACAAG 
CTCTCCAAGC AGATGGTGGA CGTTAAGGAA AATTACCAGA GCACCCTGCC CAAAGCTGAG 
GCTCCCCGAG AGCCGGAGCG GGGAGGGCCC GCCAAGTCAG CATTCCAGCC GGTGATTGCA 
ATGGACACCG AACTGCTGCG ACAACAGAGA CGCTACAACT CACCGCGGGT CCTGCTGAGC 
GACAGCACCC CCTTGGAGCC CCCGCCCTTG TATCTCATGG AGGATTACGT GGGCAGCCCC 
GTGGTGGCGA ACAGAACATC ACGGCGGAAA CGGTACGCGG AGCATAAGAG TCACCGAGGG 
GAGTACTCGG TATGTGACAG TGAGAGTCTG TGGGTGACCG ACAAGTCATC GGCCATCGAC 
ATTCGGGGAC ACCAGGTCAC GGTGCTGGGG GAGATCAAAA CGGGCAACTC TCCCGTCAAA 
CAATATTTTT ATGAAACGCG ATGTAAGGAA GCCAGGCCGG TCAAAAACGG TTGCAGGGGT 
ATTGATGATA AACACTGGAA CTCTCAGTGC AAAACATCCC AAACCTACGT CCGAGCACTG 
ACTTCAGAGA ACAATAAACT CGTGGGCTGG CGGTGGATAC GGATAGACAC GTCCTGTGTG 
TGTGCCTTGT CGAGAAAAAT CGGAAGAACA TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001096124.1
CDS	218..1030
Translation	MVTFATILQVNKVMSILFYVIFLAYLRGIQGNNMDQRSLPEDSLNSLIIKLIQADILKNKLSKQMVDVKENYQSTLPKAEAPREPERGGPAKSAFQPVIAMDTELLRQQRRYNSPRVLLSDSTPLEPPPLYLMEDYVGSPVVANRTSRRKRYAEHKSHRGEYSVCDSESLWVTDKSSAIDIRGHQVTVLGEIKTGNSPVKQYFYETRCKEARPVKNGCRGIDDKHWNSQCKTSQTYVRALTSENNKLVGWRWIRIDTSCVCALSRKIGRT

Target ORF information:

RefSeq Version	NM_001102654.2
Organism	Homo sapiens(human)
Definition	Homo sapiens neurotrophin 3 (NTF3), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001102654.2

ORF Insert Sequence:

ATGGTTACTT TTGCCACGAT CTTACAGGTG AACAAGGTGA TGTCCATCTT GTTTTATGTG 
ATATTTCTCG CTTATCTCCG TGGCATCCAA GGTAACAACA TGGATCAAAG GAGTTTGCCA 
GAAGACTCGC TCAATTCCCT CATTATTAAG CTGATCCAGG CAGATATTTT GAAAAACAAG 
CTCTCCAAGC AGATGGTGGA CGTTAAGGAA AATTACCAGA GCACCCTGCC CAAAGCTGAG 
GCTCCCCGAG AGCCGGAGCG GGGAGGGCCC GCCAAGTCAG CATTCCAGCC GGTGATTGCA 
ATGGACACCG AACTGCTGCG ACAACAGAGA CGCTACAACT CACCGCGGGT CCTGCTGAGC 
GACAGCACCC CCTTGGAGCC CCCGCCCTTG TATCTCATGG AGGATTACGT GGGCAGCCCC 
GTGGTGGCGA ACAGAACATC ACGGCGGAAA CGGTACGCGG AGCATAAGAG TCACCGAGGG 
GAGTACTCGG TATGTGACAG TGAGAGTCTG TGGGTGACCG ACAAGTCATC GGCCATCGAC 
ATTCGGGGAC ACCAGGTCAC GGTGCTGGGG GAGATCAAAA CGGGCAACTC TCCCGTCAAA 
CAATATTTTT ATGAAACGCG ATGTAAGGAA GCCAGGCCGG TCAAAAACGG TTGCAGGGGT 
ATTGATGATA AACACTGGAA CTCTCAGTGC AAAACATCCC AAACCTACGT CCGAGCACTG 
ACTTCAGAGA ACAATAAACT CGTGGGCTGG CGGTGGATAC GGATAGACAC GTCCTGTGTG 
TGTGCCTTGT CGAGAAAAAT CGGAAGAACA TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Brain-derived neurotrophic factor (BDNF) and neurotrophin 3 (NT3) levels in post-mortem brain tissue from patients with depression compared to healthy individuals?-?a proof of concept study.
European psychiatry : the journal of the Association of European Psychiatrists4665-71(2017 Oct)
Sheldrick A,Camara S,Ilieva M,Riederer P,Michel TM

Autophagy and TrkC/NT-3 signaling joined forces boost the hypoxic glioblastoma cell survival.
Carcinogenesis38(6)592-603(2017 Jun)
Jawhari S,Bessette B,Hombourger S,Durand K,Lacroix A,Labrousse F,Jauberteau MO,Ratinaud MH,Verdier M

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NTF3 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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